<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6590">
    <dcterms:title><![CDATA[<strong>Trypanosoma cruzi-Derived Molecules Induce Anti-Tumour Protection by Favouring Both Innate and Adaptive Immune Responses</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[TRYPANOSOMA CRUZI]]></dcterms:subject>
    <dcterms:subject><![CDATA[CANCER DE PULMON]]></dcterms:subject>
    <dcterms:subject><![CDATA[GLICOSILACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[INMUNIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[INMUNIDAD INNATA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Lung cancer remains the leading cause of cancer mortality worldwide. Thus, the development of strategies against this type of cancer is of high value. Parasite infections can correlate with lower cancer incidence in humans and their use as vaccines has been recently explored in preclinical models. In this study, we investigated whether immunisations with a Trypanosoma cruzi lysate from epimastigotes protect from lung tumour growth in mice. We also explore the role of parasite glycans in the induction of the protective immune response. A pre-clinical murine cancer model using the lung tumour cell line LL/2 was used to evaluate the anti-tumour potential, both in preventive and therapeutic settings, of a T. cruzi epimastigote-derived protein lysate. Immunisation with the parasite lysate prevents tumour growth and induces both humoral and cellular anti-tumour immune responses to LL-2 cancer cells. The induced immunity and tumour protection were associated with the activation of natural killer (NK) cells, the production of interferon- (IFN- ) and tumour cell cytotoxicity. We also show that mannose residues in the T. cruzi lysate induce Toll-like receptor (TLR) signalling. The evaluated T. cruzi lysate possesses anti-tumour properties likely by activating innate and adaptive immunity in a process where carbohydrates seem to be essential.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Freire, Teresa</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Landeira, Mercedes</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Giacomini, Cecilia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Festari, Mar&iacute;a Florencia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pittini, &Aacute;lvaro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cardozo, Viviana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Brosque, Alina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Monin, Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>da Costa, Valeria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Faral-Tello, Paula</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Robello, Carlos</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Osinaga, Eduardo</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[International Journal of Molecular Sciences, v.23,2022. --]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<div class="element-text">
<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
</div>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[18 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3390/ijms232315032]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6588">
    <dcterms:title><![CDATA[Do bioactive 8-hydroxyquinolines oxidovanadium(IV) and (V) complexes inhibit the growth of M. smegmatis?]]></dcterms:title>
    <dcterms:subject><![CDATA[<div class="element-text">MYCOBACTERIUM SMEGMATIS</div>]]></dcterms:subject>
    <dcterms:subject><![CDATA[OXIDOVANADIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[VANADIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[ESPECIACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS DE COORDINACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The antiproliferative effects of four series of VIVO- and VVO-based compounds containing 8-hydroxyquinoline ligands on the bacterium Mycolicibacterium smegmatis (M. smeg) were investigated. The effects on M. smeg were compared to the antiproliferative effects on the protozoan parasite Trypanosoma cruzi (T. cruzi), the causative agent for Chagas disease. In this study, we investigate the speciation of these compounds under physiological conditions as well as the antiproliferative effects on the bacterium M. smeg. We find that the complexes are more stable the less H2O is present, and that the stability increases in lipid-like environments.<br />Only one heteroleptic complex and two homoleptic complexes were found to show similar antiproliferative effects on M. smeg as reported for T. cruzi so the responses generally observed by M.smeg. is less than observed by the pathogen. In summary, we find that M. smeg is more sensitive to the detailed structure of the V-complex but overall these complexes are less effective against M. smeg compared to T. cruzi.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[Scalese, Gonzalo]]></dcterms:creator>
    <dcterms:creator><![CDATA[Arhouma, Zeyad]]></dcterms:creator>
    <dcterms:creator><![CDATA[Kostenkova, Kateryna]]></dcterms:creator>
    <dcterms:creator><![CDATA[P&eacute;rez-D&iacute;az, Leticia]]></dcterms:creator>
    <dcterms:creator><![CDATA[C. Crick, Dean]]></dcterms:creator>
    <dcterms:creator><![CDATA[Gambino, Dinorah]]></dcterms:creator>
    <dcterms:creator><![CDATA[Crans, Debbie C.]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Inorganic Biochemistry, v.237, 2022. -- e111984]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<div class="element-text">
<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span></div>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[15 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:identifier><![CDATA[10.1016/j.jinorgbio.2022.111984]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6587">
    <dcterms:title><![CDATA[<strong>Possible molecular basis of the biochemical effects of cysteine-derived persulfides</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CISTEINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[PERSULFURO]]></dcterms:subject>
    <dcterms:subject><![CDATA[SULFURO DE HIDROGENO]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPUESTOS DE SULFHIDRILO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Persulfides (RSSH/RSS&minus; ) are species closely related to thiols (RSH/RS&minus; ) and hydrogen sulfide (H2S/HS&minus; ), and can be formed in biological systems in both low and high molecular weight cysteine-containing compounds. They are key intermediates in catabolic and biosynthetic processes, and have been proposed to participate in the transduction of hydrogen sulfide effects. Persulfides are acidic, more acidic than thiols, and the persulfide anions are expected to be the predominant species at neutral pH. The persulfide anion has high nucleophilicity, due in part to the alpha effect, i.e., the increased reactivity of a nucleophile when the neighboring atom has high electron density. In addition, persulfides have electrophilic character, a property that is absent in both thiols and hydrogen sulfide. In this article, the biochemistry of persulfides is described, and the possible ways in which the formation of a persulfide could impact on the properties of the biomolecule involved are discussed.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Cuevasanta, Ernesto</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?9f34ee6db8be562f9656bfc79906e7f3812527a7024a7ee12730d347af7c4857e73b3275ddd109e0b0f3f82cf56c77113c6f6423e6e533dcc0b77e1036c610a3" target="_blank"><strong>Benchoam, Dayana</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Semelak, Jonathan A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>M&ouml;ller Rodr&iacute;guez, Mat&iacute;as Nicol&aacute;s</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Zeida Camacho, Ari Fernando</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Trujillo Garr&eacute;, Madia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Alvarez, Beatriz</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Estrin, Dar&iacute;o A.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Frontiers in Molecular Biosciences, v. 9, 2022.]]></dcterms:source>
    <dcterms:publisher><![CDATA[Frontiers]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[9 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3389/fmolb.2022.975988]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6586">
    <dcterms:title><![CDATA[<strong>A different transcriptional landscape sheds light on Russian sturgeon (Acipenser gueldenstaedtii) mechanisms to cope with bacterial infection and chronic heat stress</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[PECES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[turgeons are chondrostean fish of high economic value and critically endangered due to anthropogenic activ ities, which has led to sturgeon aquaculture development. Russian sturgeon (Acipenser gueldenstaedtii), the second most important species reared for caviar, is successfully farmed in subtropical countries, including Uruguay. However, during the Uruguayan summer, sturgeons face intolerable warmer temperatures that weaken their defences and favour infections by opportunistic pathogens, increasing fish mortality and farm economic losses. Since innate immunity is paramount in fish, for which the liver plays a key role, we used deep RNA sequencing to analyse differentially expressed genes in the liver of Russian sturgeons exposed to chronic heat stress and challenged with Aeromonas hydrophila. We assembled 149.615 unigenes in the Russian sturgeon liver tran scriptome and found that metabolism and immune defence pathways are among the top five biological processes taking place in the liver. Chronic heat stress provoked profound effects on liver biological functions, up regulating genes related to protein folding, heat shock response and lipid and protein metabolism to meet en ergy demands for coping with heat stress. Besides, long-term exposure to heat stress led to cell damage triggering liver inflammation and diminishing liver ability to mount an innate response to A. hydrophila challenge. Accordingly, the reprogramming of liver metabolism over an extended period had detrimental effects on fish health, resulting in weight loss and mortality, with the latter increasing after A. hydrophila challenge. To our knowledge, this is the first transcriptomic study describing how chronic heat-stressed sturgeons respond to a bacterial challenge, suggesting that liver metabolism alterations have a negative impact on the innate anti bacterial response.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?493bc8a6cd17339e96de7dfd28a4d0be4a1ea51e29476ad106c5e20df445100e7fbad2018af2a594d5ae0847ea56c061d3c60d9e66a12ec526f9e347e37c6c73" target="_blank"><strong>Cost&aacute;bile, Alicia</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Castellano, Mauricio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?635e5983c8fb725d22de6da3e884cde8" target="_blank"><strong>Aversa Marnai, Marcio</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Quartiani, Ignacio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Conijeski, Daniel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Perretta, Alejandro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Villarino, Andrea</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?c8cfc8471d24f5bf36f470307a0e5459c4df30a9f7703dfce22e764292a89348f8eed0d41fc3eea937289b633a4dbf4cdd213242b9b9aa045209987742c97744" target="_blank"><strong>Silva &Aacute;lvarez, Valeria</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?39f6ec9ed1fa74a6c28d0da36e2fca3d858b54ceb642d70e5c10eed8d37d9bf3739f963af878e54b3abd6592c806c913585b221376484d755570915a2a8eccc0" target="_blank"><strong>Ferreira, Ana Mar&iacute;a</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Fish and shell fish immunology, v. 128, 2022. -- pp. 505-522]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[18 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.fsi.2022.08.022]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6585">
    <dcterms:title><![CDATA[<strong>Complete genome sequence resource for Xanthomonas translucens pv. undulosa MAI5034 : a wheat pathogen from Uruguay</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[GENETICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRIGO]]></dcterms:subject>
    <dcterms:subject><![CDATA[XANTHOMONAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BACTERIAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?26522ae46633407d2f38d082312900a92e83aa5269f8fdc4fae78830064a5c91bc596887a707669ff91ca98be5484a4d93bdb300d96b69a0c2c1c62dc0409f78" target="_blank"><strong>Clavijo, Felipe</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Barrera, Claudia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bencic, Aleksander</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?6c5b59004f44d88154b5c14a391c3147fc46e2e3d308ce89f431b7df255ea35593ddc1822f5f8bb849fe0d762424273dd1d88c1d83e508f907870d44107a0420" target="_blank"><strong>Croce, Valentina</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Jacobs, Jonathan M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bernal, Adriana J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Koebnik, Ralf</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Roman Reyna, Veronica</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Phytopathology, v.112, n&deg;9, 2022. -- pp. 2036-2039]]></dcterms:source>
    <dcterms:publisher><![CDATA[APS Publications]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[4 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1094/PHYTO-01-22-0025-A]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6584">
    <dcterms:title><![CDATA[<strong>ISCOM-Matrices Nanoformulation Using the Raw Aqueous Extract of Quillaja lancifolia (Q. brasiliensis)</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[QUILLAJA BRASILIENSIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[SAPONINAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[VACUNAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[NANOTECNOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Quillaja saponins have an intrinsic capacity to interact with membrane lipids that self-assembles in nanoparticles (immu nostimulating complexes or ISCOM-matrices) with outstanding immunoadjuvant activity and low toxicity profle. However, the expensive and laborious purifcation processes applied to purify Quillaja saponins used to assemble ISCOM-matrices show an important drawback in the large-scale use of this vaccine adjuvant. Thus, in this study, we describe a protocol to appropriately formulate ISCOM-matrices using the raw aqueous extract (AE) of Quillaja lancifolia leaves. In the presence of lipids, AE was able to self-assemble in nanostructures that resembles immunostimulating complexes (ISCOM). These nega tively charged nanoparticles of approximately 40 nm were characterized by transmission electron microscopy and dynamic light scattering. In addition, well-known saponins with remarkable immunoadjuvant activity, as QS-21, were detected into nanoparticles. Thus, the easier, robust, cheaper, and environmentally friendly method developed here may be an alternative to the classical methods for ISCOM-matrices production that use high-purifed saponins.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Cibulski, Samuel Paulo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Amorim de Souza, Thalisson</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Raimundo, Joanda Paola</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mangueira Nascimento, Yuri</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Silva Abreu, Lucas</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Su&aacute;rez Olivera, Norma</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?fff9206a83386ce414ac2d4d58c00b9b92cfe2c0daf8af28bce72589d7caec886367158e5f173950e50660448119dda8d7440f347a7eeb69978a04e756a13f77" target="_blank"><strong>Miraballes, Iris</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Roehe, Paulo Michael</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Machado de Ara&uacute;jo, Demetrius Antonio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fechine Tavares, Josean</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sobral da Silva, Marcelo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Silveira, Fernando</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[BioNanoScience v. 12, 2022. -- pp. 1166&ndash;1171]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[6 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1007/s12668-022-01023-8]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6583">
    <dcterms:title><![CDATA[<strong>Ubiquity and diversity of cold adapted denitrifying bacteria isolated from diverse Antarctic ecosystems</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANTARTIDA]]></dcterms:subject>
    <dcterms:subject><![CDATA[DESNITRIFICACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[BACTERIAS DESNITRIFICANTES]]></dcterms:subject>
    <dcterms:subject><![CDATA[NITROGENO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Nitrogen cycle has been poorly investigated in Antarctic ecosystems. In particular, how extreme conditions of low temperature, dryness, and high radiation select the microorganisms involved in the cycle is not yet understood. Denitrification is an important step in the nitrogen cycle in which nitrate is reduced stepwise to the gases NO, N2O, and N2. Denitrification is carried out by a wide group of microorganisms spread in the phylogenetic tree. The aim of this work was to isolate and characterize denitrifying bacteria present in different cold environments from Antarctica. Bacterial isolates were obtained from lake, meltwater, sea, glacier ice, ornithogenic soil, and penguin feces samples from King George Island, Fildes peninsula in the Antarctic. Samples were taken during the deicing season in five sampling campaigns. From all the samples we were able to isolate denitrifying strains. A total of 199 bacterial isolates with the capacity to grow in anaerobic mineral media reducing nitrate at 4&deg;C were obtained. The characterization of the isolates by 16S rRNA gene sequence analysis showed a high predominance of the genus Pseudomonas, followed by Janthinobacterium, Flavobacterium, Psychrobacter, and Yersinia. Other minor genera detected were Cryobacterium, Iodobacter, Kaistella, and Carnobacterium. The capacity to denitrify was not previously described for most of the bacteria related to our isolates and in many of them denitrifying genes were not present suggesting the presence of new genes in this extreme environment. Our work demonstrates the ubiquity of denitrification in the Maritime Antarctica and gives important information linking denitrification at cold temperature with taxa in an unequivocal way.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Cabezas, &Aacute;ngela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Azziz, Gast&oacute;n</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bovio Winkler, Patricia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fuentes, Laura</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Braga, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Wenzel, Jorge</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sabaris, Silvia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?db6409851364d93a86a1eef366b750bfdecb99cef35448d5c99e65b5b9ad2b2eabb63b9214c1f9c5f7419ade2600ba880ea6a1d64ae348dd45dfc292e112017f" target="_blank"><strong>Tarlera, Silvana</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Etchebehere, Claudia</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Frontiers in microbiology, v. 13, 2022.-- e827228]]></dcterms:source>
    <dcterms:publisher><![CDATA[Frontiers]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[14 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3389/fmicb.2022.827]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6582">
    <dcterms:title><![CDATA[<strong>From a novel synthesis method for bismuth tri-iodide nanoparticles to a solution-processed hybrid material : BiI3-conducting polymer</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[NANOTECNOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[NANOPARTICULAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[POLIMEROS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRIYODURO DE BISMUTO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[We successfully synthesized two types of bismuth tri-iodide nanoparticles: uncapped (BiI3) and capped with aniline (BiI3_ani), in order to study their potential as inorganic semiconductor for an organic&ndash;inorganic hybrid material with poly(3-hexylthiophene-2,5-diyl) (P3HT). We developed a novel direct synthesis method that avoids ligand exchange (for BiI3_ani), as well as the necessity of capping agent removal steps (for BiI3) and the formation of sec ondary compounds obtained by other techniques. Additionally, we evaluated and compared the properties of solution-processed P3HT:nanoparticles layers with the film sequence ITO/PEDOT:PSS/P3HT:nanoparticles, where ITO is indium tin oxide and PEDOT:PSS is poly(3,4-ethylenedioxythiophene) poly styrene sulfonate. We analyzed the layers by UV&ndash;Vis spectroscopy, X-ray diffraction, focused ion beam scanning electron microscopy and photolumi nescence analysis. We proved that aniline restricts the growth of nanoparticles and improves the processability of the material compared to nanoparticles without capping agent. We demonstrated that both types of nanoparticles can be successfully suspended in a solvent in which P3HT is soluble, improve the UV&ndash;Vis absorption of P3HT and interact with this polymer leading to an improved crystalline ordering on the blends compared to pristine P3HT layers. We also demonstrated that BiI3 nanoparticles produce a nanoscopic mixture with P3HT and that it is possible to exploit the photoluminescence emission of P3HT:BiI3_ani layers. Our results show that both types of nanoparticles can be good candidates for use in solution-processed organic&ndash;inorganic hybrid material with P3HT, which could be employed for the fabrication of hybrid polymeric&ndash;inorganic solar cells with BiI3 nanoparticles as electron acceptor and P3HT as electron donor.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Bethencourt Ramos, Loengrid Karina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?eb05af54e8688a7393c7457148063acf342670300c9d3be26f9a361391b035515e0faa9348d01d2f06508c0b2e370a250fc1d36e812ed8612f610da0d3984df6" target="_blank"><strong>Aguiar, Ivana</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez Barthaburu, Mar&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Oreggioni, Daniela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa de Santana, Ricardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Queiroz Maia, Lauro June</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fornaro, Laura</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Materials Science, v. 57, 2022. -- pp. 17592-17608]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[17 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1007/s10853-022-07703-w]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6581">
    <dcterms:title><![CDATA[<strong>Impaired hippocampal neurogenesis and cognitive performance in adult DBC1-knock out mice</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[PROTEINAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[NEUROGENESIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[MEMORIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[RATONES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The protein DBC1 is the main SIRT1 regulator known so far, and by doing so, it is involved in the regulation of energy metabolism, especially in liver and fat adipose tissue. DBC1 also has an important function in cell cycle progression and regulation in cancer cells, affecting tumorigenesis. We recently showed that during quiescence, non-transformed cells need DBC1 in order to re-enter and progress through the cell cycle. Moreover, we showed that deletion of DBC1 affects cell cycle progression during liver regeneration. This novel concept prompted us to evaluate the role of DBC1 during adult neurogenesis, where transition from quiescence to proliferation in neuronal progenitors is key and tightly regulated. Herein, we analyzed several markers of cell cycle expressed in the dentate gyrus of the hippocampus of controls and DBC1 KO adult mice. Our results suggest a reduced number of neuroblasts therein present, probably due to a decline of neuroblast generation or an impairment in neural differentiation. In agreement with this, we also found that adult DBC1 KO mice had a reduction in the volume of the granule cell layer of the dentate gyrus. Interestingly, behavioral analysis of KO and control mice revealed that deletion of DBC1 parallels to specific cognitive impairments, concerning learning and possibly memory forma tion. Our results show, for the first time, that DBC1 plays an active role in the nervous system. In particular, specific anatomical and behavioral changes are observed when is absent.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Ben&iacute;tez Rosendo, Andr&eacute;s</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lagos, Patricia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cal, Karina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?6e0034bfb7fc0cef4cf78165046a49d6290be12e92d8c2619e35fee132e043db1522b45f826eb80e7b088ea00b94fb51d2ccc57285dd99c2eb95c6622e39eadf" target="_blank"><strong>Colman, Laura</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Escande, Carlos</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Calliari Cuadro, Aldo Jos&eacute;</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Molecular and cellular neuroscience, v.123, 2022. -- pp. 1-14. -- e103781]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[14 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.mcn.2022.103781]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6580">
    <dcterms:title><![CDATA[<strong>Health-related cues on the packages of processed and ultra-processed products: prevalence and policy implications</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[EMBALAJE]]></dcterms:subject>
    <dcterms:subject><![CDATA[ETIQUETADO]]></dcterms:subject>
    <dcterms:subject><![CDATA[MARKETING]]></dcterms:subject>
    <dcterms:subject><![CDATA[NUTRICION]]></dcterms:subject>
    <dcterms:subject><![CDATA[SALUD]]></dcterms:subject>
    <dcterms:subject><![CDATA[POLITICA ALIMENTARIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ADVERTENCIAS NUTRICIONALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The information included on food packages has a crucial role in influencing consumer product associations and purchase decisions. In particular, visual and textual cues on processed and ultra-processed products can convey health-related associations that influence consumer healthiness perception and purchase decisions. In this context, the present work aimed to explore the use of health-related cues on the packages of processed and ultra processed products sold in Uruguay to provide insights for policy making. A total of 3813 products from 34 different food categories found in four of the most important supermarket chains in Uruguay were surveyed. The textual and visual information included on the packages as well as the nutritional composition of the products were analyzed. Results showed that 67% of the products included at least one health-related cue. Pictures of culinary ingredients, natural and minimally processed foods were the most frequent health-related cue, followed by references to naturalness and claims related to critical nutrients. The prevalence of health-related cues largely differed across product categories, ranging from 100% to 17%. The relationship between the presence of health-related cues on the packages and the excessive content of nutrients associated with non-communicable diseases was assessed using a gradient boosting model, which showed limited predictive ability. This suggests that the inclusion of health-related cues on food packages was not strongly related to the nutritional composition of products and therefore cannot be regarded as a healthiness indicator. These results stress the need of develop stricter labeling regulations to protect consumers from misleading information.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Alcaire, Florencia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vidal, Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mach&iacute;n, Leandro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ant&uacute;nez, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gim&eacute;nez, Ana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Curutchet, Mar&iacute;a Rosa</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ares, Gast&oacute;n</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[British Journal of Nutrition, 2022]]></dcterms:source>
    <dcterms:publisher><![CDATA[The nutrition society]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1017/S000711452200318X]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6578">
    <dcterms:title><![CDATA[<strong>Consumer conceptualisations of food-related wellbeing : an exploration of wellbeing-related terms in four industrialised countries</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CONSUMIDORES]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPORTAMIENTO DEL CONSUMIDOR]]></dcterms:subject>
    <dcterms:subject><![CDATA[ASOCIACION DE PALABRAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIENESTAR]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<p>Perceived (or subjective) wellbeing is regarded as key to understanding consumer food choices and the devel opment of strategies to promote desirable eating habits. Yet, in-depth understanding of the specific factors that contribute to people&rsquo;s perceived wellbeing across cultures is lacking. These factors motivated the present research that used word associations to conduct an exploratory analysis of consumer conceptualisations of food related wellbeing (WB). Adults (n = 4945) living in the United Kingdom, Australia, Singapore or Germany, and speaking respectively, English or German, took part in the study. Health, pleasure, food quality, positive emo tions and social aspects of food consumption were the main associations with food-related wellbeing. Absence hereof was associated with unhealthiness, disgust, negative emotions and poor mental health. The differences in these main associations emphasised the importance of exploring wellbeing, as well as lack hereof. Not doing so leads to an incomplete understanding of this multidimensional construct. The research was conducted with four terms related to wellbeing (each in their positive and negative versions): &lsquo;sense of wellbeing&rsquo; and &lsquo;lack of wellbeing&rsquo;, &lsquo;feeling good&rsquo; and &lsquo;feeling bad/unhappy&rsquo;, &lsquo;satisfied with life&rsquo; and &lsquo;dissatisfied with life&rsquo; and &lsquo;fulfilled in life&rsquo; and &lsquo;unfulfilled in life&rsquo;. Because these different terms gave rise to different wellbeing associations, re searchers in this area must choose their empirical approach with care. The terms &lsquo;sense of wellbeing&rsquo; and &lsquo;feeling good&rsquo; tended to more frequently give rise to health-related associations. Conversely, &lsquo;satisfied with life&rsquo; and &lsquo;fulfilled in life&rsquo; tended to more frequently give rise to positive spiritual and emotional associations of food related wellbeing.&nbsp;The main conceptualisations of food-related wellbeing were cross-culturally similar, but extension of the present research to other Asian countries was recommended based on several differences be tween Singaporean participants and those from other countries. In ethnically diverse countries like Singapore, further within-country investigations of different cultures will also have merit.</p>
<p>&nbsp;</p>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Jaeger, Sara R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?e13bee77c03cddbef59b397e314055a6622de73c70417f3162757bfad754bfa8ad01125204736ed535ca050230cfa514a6e43d3d2464b7fea2cb77f4995d0c4b" target="_blank"><strong>Vidal, Leticia</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Chheang, Sok L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?e41ee09b825f22635cb8a1e9b42b334d75d1c2be0ccaad4f086d148a0ebac442b4a82cfb05ef977a8fe31965e28ee4bb8889f1ccb549f56f20a9403e2c02a0cf" target="_blank"><strong>Ares, Gast&oacute;n</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Appetite, v. 179, 2022. -- pp. 1-14. -- e106286]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[14 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.appet.2022.106286]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6577">
    <dcterms:title><![CDATA[<strong>Production of antioxidant whey hydrolysate using proteolytic extracts of Araujia sericifera var. hortorum latex</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[PEPTIDOS BIOACTIVOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ARAUJIA SERICIFERA]]></dcterms:subject>
    <dcterms:subject><![CDATA[LATEX]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIOXIDANTES]]></dcterms:subject>
    <dcterms:subject><![CDATA[ENZIMAS PROTEOLITICAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[SUERO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Proteins in whey from casein production were hydrolyzed with proteolytic extracts from the latex of Araujia sericifera var. hortorum. Hydrolysate fractions that were partially purified by RP-HPLC and evaluated using the ORAC method resulted in an antioxidant capacity of 112.4 &plusmn; 4.2 Trolox equivalents (&mu;M). LC&ndash;MS/MS analysis of peptide fractions showed that peptides derived from &beta;-lactoglobulin could be responsible for antioxidant activity. The sum of these results along with the fact that a controlled and reproducible production process was used, involving the use of natural resources and reaction conditions without excessive costs at an industrial scale, makes a promising contribution to improving antioxidant dairy products.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?cb6c39ce9fa9260c8895a690627006bf1dd0b244b0c78eb1956c95b96eb11933581148725c79df7c87baaf5b48ec4151d1f37e2cfe0a1a8e04c8392a5ba722e9" target="_blank"><strong>Barros, M.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Villad&oacute;niga, C.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cantera, A.M.B.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Biocatalysis and agricultural biotechnology, v.44, 2022.-- pp. 1-12. -- e102453]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[12 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.bcab.2022.102453]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6576">
    <dcterms:title><![CDATA[<strong>Thioester deprotection using a biomimetic NCL approach</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[TIOL]]></dcterms:subject>
    <dcterms:subject><![CDATA[TIOESTER]]></dcterms:subject>
    <dcterms:subject><![CDATA[ESTERIFICACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRANSESTERIFICACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[LIGADURA QUIMICA NATIVA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The reversibility of the thiol-thioester linkage has been broadly employed in many fields of biochemistry (lipid synthesis) and chemistry (dynamic combinatorial chemistry and material science). When the transthioesterification is followed by a S-to-N acyl transfer to give an amide bond, it is called Native Chemical Ligation (NCL), a high-yield chemoselective process used for peptide synthesis. Recently, we described thioglycolic acid (TGA) as a useful reagent for thioester deprotection both in solution and anchored to a solid-support under mild conditions. Inspired by NCL, in this work, we extended this approach and explored the use of 2-aminothiols for the deprotection of thiols bearing an acyl group. The best results were obtained using cysteamine or L-cysteine in an aqueous buffer pH 8 at room temperature for 30 min. The described approach was useful for S-acetyl, S-butyryl, and S-benzoyl heterocycles deprotection with yields up to 84%. Employing this methodology, we prepared six new analogs 2 of mercaptomethyl bisthiazolidine 1, a useful inhibitor of a wide-range of Metallo-&beta;-Lactamases (MBLs). Compared with the previous methodologies (TGA polymer supported and TGA in solution), the biomimetic deprotection herein described presents better performance with higher yields, shorter reaction times, less timeconsuming operations, easier setup, and lower costs.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Villamil, Valentina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Saiz, Cecilia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mahler, Graciela</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Frontiers in Chemistry v.10, 2022.-- e934376.]]></dcterms:source>
    <dcterms:publisher><![CDATA[Frontiers]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[12 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3389/fchem.2022.934376]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6575">
    <dcterms:title><![CDATA[<strong>Caenorhabditis elegans as a valuable model for the study of anthelmintic pharmacodynamics and drug-drug interactions : the case of ivermectin and eprinomectin</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[FARMACOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[RESISTENCIA ANTIPARASITARIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[PARASITOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[HELMINTOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[NEMATODA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Caenorhabditis elegans is a free-living nematode that has been validated for anthelmintic drug screening. However, this model has not been used to address anthelmintic dose-response-time and drug-drug interactions through matrix array methodology. Eprinomectin (EPM) and Ivermectin (IVM) are macrocyclic lactones widely used as anthelmintics. Despite being very similar, EPM and IVM are combined in commercial formulations or mixed by farmers, under the assumption that the combination would increase their efficacy. However, there is no data reported on the pharmacological evaluation of the combination of both drugs. In this study, we assessed the pharmacodynamics and drug-drug interactions of these two anthelmintic drugs. Since the action of these drugs causes worm paralysis, we used an infrared motility assay to measure EPM and IVM effects on worm movement over time. The results showed that EPM was slightly more potent than IVM, that drug potency increased with drug time exposure, and that once paralyzed, worms did not recover. Different EPM/IVM concentration ratios were used and synergy and combination sensitivity scores were determined at different exposure times, applying Highest Single Agent (HSA), Loewe additivity, Bliss and Zero Interaction Potency (ZIP) models. The results clearly indicate that there is neither synergy nor antagonism between both macrocyclic lactones. This study shows that it is more relevant to prioritize the exposure time of each individual drug than to combine them to improve their effects. The results highlight the utility of C. elegans to address pharmacodynamics studies, particularly for drug-drug interactions. Models in vitro can be integrated to facilitate preclinical and clinical translational studies and help researchers to understand drug-drug interactions and achieve rational therapeutic regimes.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Su&aacute;rez, Gonzalo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Alc&aacute;ntara, Ignacio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?972518dae04cc6f1d53fd01909f7c2f4952184c3eedf364530afd35a4c507484cce1f86606ac8d829a37e89b7a9f837b6b0632e94efbaf9ba6abf23efe48f1dc" target="_blank"><strong>Salinas, Gustavo</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Frontiers in pharmacology, 2022.]]></dcterms:source>
    <dcterms:publisher><![CDATA[Frontiers]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[9 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3389/fphar.2022.984905]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6574">
    <dcterms:title><![CDATA[<strong>Editorial : rational drug design of metal complexes for cancer therapy</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CANCER]]></dcterms:subject>
    <dcterms:subject><![CDATA[FARMACOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:creator><![CDATA[<strong>Morais, T&acirc;nia S.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fernandes, Alexandra R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Baptista, Pedro V.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?6bb5dcce3e2559101357796ca4a2b2d4c9ba6b3a978a0bd4c5dab0107081b73e1ff46dcf49a7de2b571ff7980c4a01789f09f1d7eac1b879a8553641f940b9a5" target="_blank"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Frontiers in chemistry, 2022]]></dcterms:source>
    <dcterms:publisher><![CDATA[Frontiers]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo editorial]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3389/fchem.2022.1035274]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6573">
    <dcterms:title><![CDATA[<strong>Predicting mandarin fruit acceptability : from high-field to Benchtop NMR spectroscopy</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ESPECTROSCOPIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[FRUTAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[MANDARINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ESPECTROSCOPIA DE RESONANCIA MAGNETICA NUCLEAR]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Recent advances in nuclear magnetic resonance (NMR) have led to the development of low-field benchtop NMR systems with improved sensitivity and resolution suitable for use in research and quality-control laboratories. Compared to their high-resolution counterparts, their lower purchase and running costs make them a good alternative for routine use. In this article, we show the adaptation of a method for predicting the consumer acceptability of mandarins, originally reported using a high-field 400 MHz NMR spectrometer, to benchtop 60 MHz NMR systems. Our findings reveal that both instruments yield comparable results regarding sugar and citric acid levels, leading to the development of virtually identical predictive linear models. However, the lower cost of benchtop NMR systems would allow cultivators to implement this chemometric-based method as an additional tool for the selection of new cultivars.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?4e8790094627dcd20f1718b9bf2b88bd8cea40a68b525e30bf109dc94f7fdba2109c0cf4034470b0b4d5a9f44c2bfe194152e221dd5805d9671e99e3c1a2a2d2" target="_blank"><strong>Migues, Ignacio</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rivas,&nbsp;<strong>Fernando&nbsp;</strong></strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?2cebe78e18fa760a7d79dd8a0021057dde02e9333677a6c5fcca4cd9f2ebc8ff20700be3044d46d4a23ffbe14bb8f73a516209099e443241db3b37bd796008fb" target="_blank"><strong>Moyna,&nbsp;<strong>Guillermo&nbsp;</strong></strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Kelly,&nbsp;<strong>Simon D.</strong></strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cvsni/?urlId=efdc2e4d27c46568e51501a117c8d64c661d28215277fe2b1621ea4a392338f0bd55c3b410eb66c8bd85997e02d92a5828f529ff076bd0478d3b4ffd01ec2037&amp;convocatoria=21&amp;formato=html" target="_blank"><strong>Heinzen,&nbsp;<strong>Horacio&nbsp;</strong></strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Foods, v.11, n&deg; 16, 2022. -- pp. 1-8]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[8 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi.org/10.3390/foods11162384]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6572">
    <dcterms:title><![CDATA[<strong>CD6 deficiency impairs early immune response to bacterial sepsis</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[INMUNOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[SEPSIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BACTERIAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[RECEPTORES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[CD6 is a lymphocyte-specific scavenger receptor expressed on adaptive (T) and innate (B1a, NK) immune cells, which is involved in both fine-tuning of lymphocyte activation/ differentiation and recognition of bacterial-associated molecular patterns (i.e., lipo polysaccharide). However, evidence on CD6&rsquo;s role in the physiological response to bacterial infection was missing. Our results show that induction of monobacterial and polymicrobial sepsis in Cd6 / mice results in lower survival rates and increased bacterial loads and pro-inflammatory cytokine levels. Steady state analyses ofCd6 / mice show decreased levels of natural polyreactive antibodies, concomitant with decreased cell counts of spleen B1a and marginal zone B cells. Adoptive transfer of wild-type B cells and mouse serum, as well as a polyreactive monoclonal antibody improveCd6 / mouse survival rates post-sepsis. These findings support a nonredun dant role forCD6 in the early response against bacterial infection, through homeostat ic expansion and functionality of innate-related immune cells.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Catal&aacute;, Cristina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Velasco de Andr&eacute;s, Mar&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Leyton Pereira, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Engel, Pablo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?8077d6141c1946a30df792835b6b6ef857fe8ef0419315625ad1c8238bb9aca6cff0e2e3a0117a509b98df7dc5fd1db6728b0697ffb3f71b1ca9ceb5260c5454" target="_blank"><strong>Mourglia Ettlin, Gustavo</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lozano, Francisco</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[iSciencev.25, n&deg;10, 2022]]></dcterms:source>
    <dcterms:source><![CDATA[<strong><br /></strong>]]></dcterms:source>
    <dcterms:source><![CDATA[<strong><br /></strong>]]></dcterms:source>
    <dcterms:publisher><![CDATA[Cell Press]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[14 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/ j.isci.2022.105078]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6571">
    <dcterms:title><![CDATA[<strong>Proton-transfer reactions of Re(II)-nitrosyl complexes: Potentiometric studies, DFT and TD-DFT calculations</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[REACCIONES DE TRANSFERENCIA DE PROTONES]]></dcterms:subject>
    <dcterms:subject><![CDATA[PROTONES]]></dcterms:subject>
    <dcterms:subject><![CDATA[POTENCIOMETRIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[DFT]]></dcterms:subject>
    <dcterms:subject><![CDATA[TEORIA FUNCIONAL DE LA DENSIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[TD-DFT]]></dcterms:subject>
    <dcterms:subject><![CDATA[TEORIA FUNCIONAL DE LA DENSIDAD TIEMPO DEPENDIENTE]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[In the present work, we investigated the proton-transfer reactions of Re(II)-nitrosyl complexes bearing halides and nicotinic acid (Hnic) or 6,6́-dinicotinic acid (H2dinic) trans-coordinated to the core {ReNO}3+ by potentiometry and UV - Vis absorption spectroscopy in a mixture DMSO:H2O (1:1; v:v). The presence of Hnic and H2dinic in title complexes promotes a marked decrease in the acidity (higher pK values) compared to the noncoordinated pyridine-derived ligands. The UV - Vis measurements indicate that the absorption spectra of complexes do not show any dependence on the acidity of the medium and the number of non-coordinated carboxylic units. Time-dependent Density Functional Theory (TD-DFT) calculations are performed to understand the optical properties of complexes and their response upon deprotonation. TD-DFT studies are conducted with PBE1PBE in combination with LANL2TZ on rhenium and 6&ndash;311++G(d,p) on non-metal atoms within the CPCM approach. This methodology shows a reasonable match between the measured and simulated spectra keeping the computational cost low. The nature of all absorption bands is ascribed to a ligand-metal-to-ligandmetal charge transfer (LMLMCT), in which negligible contribution from carboxylic units is detected.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Soca Rosas, Karolina</strong><br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torres, Julia</strong><br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pacheco, Mario</strong><br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ramos , Juan</strong><br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gancheff, Jorge S.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Results in Chemistry v.4, 2022. -- e100455]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[9 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.rechem.2022.100455]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6570">
    <dcterms:title><![CDATA[<strong>Pharmaceutical pollution of the world's rivers</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CONTAMINACION AMBIENTAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[CONTAMINACION GLOBAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[PRODUCTOS FARMACEUTICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[CONTAMINACION DEL AGUA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIMICROBIANOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[AGUAS RESIDUALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world&rsquo;s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7%of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of&nbsp; selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Wilkinson, John L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Boxall, Alistair B. A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Kolpin, Dana W.</strong> <br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Leung, Kenneth M. Y.</strong><br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lai, Racliffe W. S.</strong><br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Galban-Malagon, Cristobal</strong><br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Adell, Aiko D.</strong> <br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mondon, Julie</strong> <br /><br />]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Metian, Marc</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cvsni/?urlId=efdc2e4d27c46568e51501a117c8d64c661d28215277fe2b1621ea4a392338f0bd55c3b410eb66c8bd85997e02d92a5828f529ff076bd0478d3b4ffd01ec2037&amp;convocatoria=21&amp;formato=html"><strong>Heinzen, Horacio</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[OTROS AUTORES: Robert A. Marchant, Alejandra Bouzas-Monroy, Aida Cuni-Sanchez, Anja Coors, Pedro Carriquiriborde, Macarena Rojo, Chris Gordon, Magdalena Cara, Monique Moermond, Thais Luarte, Vahagn Petrosyan, Yekaterina Perikhanyan, Clare S. Mahon, Christopher J. McGurk, Thilo Hofmann, Tapos Kormoker, Volga Iniguez, Jessica Guzman-Otazo, Jean L. Tavares, Francisco Gildasio De Figueiredo, Maria T. P. Razzolini, Victorien Dougnon, Gildas Gbaguidi, Oumar Traore, Jules M. Blais, Linda E. Kimpe, Michelle Wong, Donald Wong, Romaric Ntchantcho, Jaime Pizarro, Guang-Guo Ying, Chang-Er Chen, Martha Paez, Jina Martınez-Lara, Jean-Paul Otamonga, John Pote<br />Suspense A. Ifo, Penelope Wilson, Silvia Echeverrıa-Saenz, Nikolina Udikovic-Kolic, Milena Milakovic, Despo Fatta-Kassinos, Lida Ioannou-Ttofa, Vladimıra Belusova, Jan Vymazal, Marıa Cardenas-Bustamante, Bayable A. Kassa, Jeanne Garric, Arnaud Chaumot, Peter Gibba, Ilia Kunchulia, Sven Seidensticker, Gerasimos Lyberatos, Halldor P. Halldorsson, Molly Melling, Thatikonda Shashidhar, Manisha Lamba, Anindrya Nastiti, Adee Supriatin, Nima Pourang, Ali Abediniww, Omar Abdullaha, Salem S. Gharbia, Francesco Pilla, Benny Chefet, Tom Topa, Koffi Marcellin Yao, Bakhyt Aubakirova, Raikhan Beisenova, Lydia Olaka, Jemimah K. Mulu, Peter Chatanga, Victor Ntuli, Nathaniel T. Blama, Sheck Sherif, Ahmad Zaharin Aris, Ley Juen Looi, Mahamoudane Niang, Seydou T. Traore, Rik Oldenkamp, Olatayo Ogunbanwo, Muhammad Ashfaq, Muhammad Iqbal, Ziad Abdeen, Aaron O&rsquo;Dea, Jorge Manuel Morales-Salda&ntilde;a, Marıa Custodio, Heidi de la Cruz, Ian Navarrete, Fabio Carvalho, Alhaji Brima Gogra, Bashiru M. Koroma, Vesna Cerkvenik-Flajs, Mitja Gombac, Melusi Thwala, Kyungho Choi, Habyeong Kang, John L. Celestino Ladu, Andreu Rico, Priyanie Amerasinghe, Anna Sobek, Gisela Horlitz, Armin K. Zenker, Alex C. King, Jheng-Jie Jiang, Rebecca Kariuki, Madaka Tumbo, Ulas Tezel, Turgut T. Onay, Julius B. Lejju, Yuliya Vystavna, Yuriy Vergeles, Andres Perez-Parada, Douglas B. Sims, Maritza Figyz, David Good, Charles Teta]]></dcterms:creator>
    <dcterms:source><![CDATA[PNAS v. 119, n&deg;. 8, 2022.-- e2113947119]]></dcterms:source>
    <dcterms:publisher><![CDATA[National Academy of Sciences]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[10 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1073/pnas.2113947119]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6569">
    <dcterms:title><![CDATA[<strong>Endophytic Yeasts for the Biocontrol of Phlyctema vagabunda in Apples</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[MALUS DOMESTICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[MANZANAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[PLAGAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[HONGOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[CULTIVOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[LEVADURA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ENFERMEDADES POSTCOSECHA]]></dcterms:subject>
    <dcterms:subject><![CDATA[CALIDAD DE LA FRUTA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Bull&rsquo;s-eye rot, produced by Phlyctema vagabunda, is an important postharvest disease in apples. Current measures to control infection include synthetic fungicides, in addition to the<br />application of copper hydroxide and potassium phosphite. However, growing public concern regarding fungicide residues in food has generated interest in developing non-chemical alternative control methods; biological control is one of the most promising alternatives. In this research, native<br />endophytic yeasts were isolated and evaluated for the biocontrol of P. vagabunda in apples. The mechanisms of action involved were also determined. Our research found 2 isolates, Vishniacozyma victoriae EPL4.5 and EPL29.5, which exhibited biocontrol activity against P. vagabunda at 20 C in<br />apples, the incidence of bull&rsquo;s-eye rot was reduced by 39% and 61%, respectively, and the severity of the disease was decreased by 67% and 70%, respectively, when apples were inoculated with these yeasts 24 h before applying the pathogen. The main mechanisms that could be involved<br />in the observed biocontrol activity are the ability to form biofilms and the production of volatile organic compounds.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Sep&uacute;lveda, Ximena</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Silva, Diego</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ceballos, Ricardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vero, Silvana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>L&oacute;pez, Mar&iacute;a Dolores</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<p><strong>Vargas, Marisol</strong></p>
<p>&nbsp;</p>]]></dcterms:creator>
    <dcterms:source><![CDATA[Horticulturae v. 8, n&deg;535, 2022. --]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[13 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[<a style="box-sizing: border-box; color: #4f5671; line-height: inherit; text-decoration: none; max-height: 1e+06px; font-weight: bold; font-family: Arial; font-size: 12px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff;" href="https://doi.org/10.3390/horticulturae8060535">10.3390/horticulturae8060535</a>]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6568">
    <dcterms:title><![CDATA[<strong>A Qualitative Exploration of Parents&rsquo; Food Choices During Early Childhood</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[NI&Ntilde;OS]]></dcterms:subject>
    <dcterms:subject><![CDATA[OBESIDAD INFANTIL]]></dcterms:subject>
    <dcterms:subject><![CDATA[DIETA]]></dcterms:subject>
    <dcterms:subject><![CDATA[NUTRICION]]></dcterms:subject>
    <dcterms:subject><![CDATA[HABITOS ALIMENTICIOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS ULTRAPROCESADOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Objective: To explore parents&rsquo; accounts of the goals they seek when choosing foods for their young children through the lens of goal-systems theory. Design: In-depth interviews with parents of children aged from 6 months to 5 years. Setting: Montevideo, Uruguay. Participants: Forty-two parents (aged 19&minus;44 years, 90% female). Phenomenon of Interest: Parents&rsquo; personal experiences, feelings, and opinions related to how they choose foods for their children. Analysis: Content analysis based on deductive-inductive coding. Results: Parents&rsquo; accounts confirmed they intended to pursue different goals when choosing foods for their children. Health-related goals mainly motivated the selection of healthy foods, but they also drove the selection of some ultra-processed products because of misconceptions about their healthiness. Pleasure and enjoyment motivated the selection of ultra-processed products, whereas stress avoidance was associated with selecting convenient foods. The selection of unhealthy foods raised conflicts between goals, which were solved using goal shielding, changes in risk perception and/or compensatory health beliefs. Conclusions and Implications: Results point to the need for communication campaigns and community- based interventions to introduce changes in how ultra-processed products are conceptualized and increase the associations between healthy foods and children&rsquo;s pleasure and enjoyment to promote healthier eating patterns during infancy and early childhood.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Vidal, Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Iragola, Valentina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mach&iacute;n, Leandro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Brunet, Ger&oacute;nimo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Girona, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Curutchet, Mar&iacute;a Rosa</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>de Le&oacute;n, Carolina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ares, Gast&oacute;n</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Nutrition Education and Behavior v.54, n&deg;8, 2022. --]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[12 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.jneb.2022.03.006]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6565">
    <dcterms:title><![CDATA[<strong>Meat insights : uruguayan consumers&acute;mental associations and motives underlying consumption changes</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[URUGUAY]]></dcterms:subject>
    <dcterms:subject><![CDATA[CARNES]]></dcterms:subject>
    <dcterms:subject><![CDATA[CONSUMIDORES]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPORTAMIENTO DEL CONSUMIDOR]]></dcterms:subject>
    <dcterms:subject><![CDATA[CARNE VACUNA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIENESTAR ANIMAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[SALUD]]></dcterms:subject>
    <dcterms:subject><![CDATA[NUTRICION]]></dcterms:subject>
    <dcterms:subject><![CDATA[ENCUESTAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[A telephone survey (n = 601) was conducted in Uruguay to explore participants&rsquo; mental associations with meat and the underlying reasons changes in the quantity and type of meat consumed. Participants mentioned mostly positive associations with meat&rsquo;s culinary and cultural aspects and its nutritional value as source of high-quality protein. Other associations were related to meat production, specific types of meat and cuts, meat consumption and pleasure, while price was perceived negatively. Animal welfare concerns emerged as a relevant association, but minor references were made to the effects of meat production on the environment. Changes in the amount and type of meat consumed (higher pork, chicken and cheaper cuts and beef) in the last year were mainly due to price followed by health reasons. Results emphasize the strong meat culture among Uruguayans and reveal that changes in the amount and type of meat consumed last year relate to external (price) or egoistic (health) rather than altruistic motives (ethical or environmental concerns).]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Realini, Carolina E.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?e41ee09b825f22635cb8a1e9b42b334d75d1c2be0ccaad4f086d148a0ebac442b4a82cfb05ef977a8fe31965e28ee4bb8889f1ccb549f56f20a9403e2c02a0cf" target="_blank"><strong>Ares, Gast&oacute;n</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?7dd276e2441870ffa17f20a0b26e1c6d1f5d2bf6d0e6bdc40832dca4787f1ea7e26c717086e07a5df1b47e258b828694cf34bd7bd13348216c403d4897e7969e" target="_blank"><strong>Ant&uacute;nez, Luc&iacute;a</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Brito, Gustavo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Luzardo, Santiago</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>del Campo, Marcia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Saunders, Caroline</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Farouk, Mustafa M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Montossi, Fabio M.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Meat Science v. 192, 2022. -- e108901]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.meatsci.2022.108901]]></dcterms:identifier>
    <dcterms:coverage><![CDATA[URUGUAY]]></dcterms:coverage>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6564">
    <dcterms:title><![CDATA[<strong>Bioprospecting the antibiofilm and antimicrobial activity of soil and insect gut bacteria</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[BACTERIAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[SUELO]]></dcterms:subject>
    <dcterms:subject><![CDATA[GENOMA]]></dcterms:subject>
    <dcterms:subject><![CDATA[RESISTENCIA A LOS ANTIMICROBIANOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Antimicrobial resistance is a growing concern in public health and current research shows an important role for bacterial biofilms in recurrent or chronic infections. New strategies, therefore, are necessary to overcome antimicrobial resistance, through the development of new therapies that could alter or inhibit biofilm formation. In this sense, antibiofilm natural products are very promising. In this work, a bioprospection of antimicrobial and antibiofilm extracts from Uruguayan soil bacteria and insect gut bacteria was carried out. Extracts from extracellular broths were tested for their ability to inhibit planktonic cell growth and biofilm formation. Genomic analysis of Bacillus cereus ILBB55 was carried out. All extracts were able to inhibit the growth of, at least, one microorganism and several extracts showed MICs lower than 500 &micro;g mL&minus;1 against microorganisms of clinical relevance (Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacter cloacae). Among the extracts evaluated for biofilm inhibition only ILBB55, from B. cereus, was able to inhibit, S. aureus (99%) and P. aeruginosa (62%) biofilms. Genomic analysis of this strain showed gene clusters similar to other clusters that code for known antimicrobial compounds. Our study revealed that extracts from soil bacteria and insect gut bacteria, especially from B. cereus ILBB55, could be potential candidates for drug discovery to treat infectious diseases and inhibit S. aureus and P. aeruginosa biofilms.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?14867dae31e42bac916dd239a014ebf05307b5f0672beba323b86b2e20eb6cc6aaa3e3bce940426c26c2253e3beb2457c00eec3789191ef0ccbae01b6b569bfb" target="_blank"><strong>Raffaelli, Sof&iacute;a</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Abreo, Eduardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?3b24bf39d12a78d8fbbfe18f62c27a1abbb04fd53aa77428b44ec9601027e6771fe5287cafb5eefc30c6721c6ffefd8bc5c00b685719f80cc633f77d22a73a52" target="_blank"><strong>Altier, Nora</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?1b750bf100b76dfc20f183bba3c999a198131b105044231802899c0e8b207770f73bed25793eacf639c15977dd2607dccb27e08583565ea1aee789c95a5ab465" target="_blank"><strong>V&aacute;zquez, &Aacute;lvaro</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?5b9c9936b20b7b2352e3813baf42a29613b5a147258df4cae843cd087fc76b2042c0e3be63baf8ed05b5d15613f8d17a3bececa370048a98b8d741075138e04f" target="_blank"><strong>Albor&eacute;s, Silvana</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Molecules v. 27, n&deg;6, 2022. -- e2002]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[13 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3390/ molecules27062002]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6563">
    <dcterms:title><![CDATA[An ultra-sensitive homologous chemiluminescence immunoassay to tackle penicillin allergy]]></dcterms:title>
    <dcterms:subject><![CDATA[ALERGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[NANOTECNOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[DIAGNOSTICO]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIBIOTICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[OMALIZUMAB]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Penicillin is one of the most widely used antibiotics to treat bacterial infections in clinical practice. The antibiotic undergoes degradation under physiological conditions to produce reactive compounds that in vivo bind self proteins. These conjugates might elicit an immune response and trigger allergic reactions challenging to di agnose due to the complex immunogenicity. Penicillin allergy delabeling initiatives are now part of antibiotic stewardship programs and include the use of invasive and risky in vivo tests. Instead, the in vitro quantification of specific IgE is highly useful to confirm immediate allergy to penicillins. However, discrepant results associated with the low sensitivity and accuracy of penicillin allergy in vitro tests have limited their routine diagnostic use for delabeling purposes. We aimed to develop a homologous chemiluminescence-based immunochemical method for the reliable determination of specific IgE to penicillin G, using unprecedented synthetic human-like standards. The synthetic standard targets the major antigenic determinant of penicillin G and the paratope of Omalizumab, acting as human-like specific IgE. It is a potent calibrator, highly stable, easy, and inexpensive to produce, overcoming the limitations of the pooled human serum preparations. The developed method achieved a good agreement and strong positive relationship, reaching a detection limit below 0.1 IU mL&minus; 1 and excellent reproducibility (RSD &lt;9%). The clinical sensitivity of the assay significantly increased (66%), doubling the accuracy of the reference method with an overall specificity of 100%. The new diagnostic strategy compares favorably with results obtained by the standard procedure, paving the way towards the standardization of penicillin allergy testing, and enhancing the detection sensitivity of specific IgE in serum to tackle reliably &beta;-lactam allergy delabeling.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Quintero Campos, Pedro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?5246a5ca81aeb900b0acc0265c03abd2" target="_blank"><strong>Segovia de los Santos, Paula</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ib&aacute;&ntilde;ez Echevarria, Ethel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Hern&aacute;ndez Fern&aacute;ndez de Rojas, Dolores</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Casino, Patricia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?1c1f29bd240d37882295d2531e2cfdd7bed8462cd28f84bbf32453c0ac9c793ec306557fbabc459cfa8e8564b47d63924c13a8ea78e6df85af1afa01363bc336" target="_blank"><strong>Lassabe, Gabriel</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?f843e2759f6ee96f8a16e51ceccfaeb41eb83154ba5da266ce35c9e64d7ad49b7ee8622e336b48ac9846dbe51b76b49fb1d2738fdaf473a4c75dea6e4f1afd20" target="_blank"><strong>Gonz&aacute;lez Sapienza, Gualberto</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Maquieira, &Aacute;ngel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Morais, Sergi</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Analytica Chimica Acta v.1214, 2022. -- e339940]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[8 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.aca.2022.339940]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6562">
    <dcterms:title><![CDATA[<strong>Supramolecular interaction of inositol phosphates with Cu(II) : comparative study of InsP6&ndash;InsP3</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[QUIMICA SUPRAMOLECULAR]]></dcterms:subject>
    <dcterms:subject><![CDATA[COBRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[FOSFATO]]></dcterms:subject>
    <dcterms:subject><![CDATA[INTERACCIONES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[myo-inositol phosphates are an important group of biomolecules that are present in all eukaryotic cells. The most abundant member of this family in nature is InsP6 (H12L1 ), which interacts strongly with inorganic and organic cations. This interaction is essential for determining the possible functions of this biomolecule. A few crystal structures containing InsP6, and a divalent cation, have been reported showing a great versatility of this bioligand. Ins(1,2,3)P3 (H6L2 ) is another important member of the group, usually thought as a safe cellular iron ligand. No crystal structures showing the interaction of L2 with metal ions can be found in the literature. In this work we characterized by X-ray diffraction two polynuclear complexes, [Cu3(H6L1) (phen)5] (phen = 1,10-phenanthroline) (1) and [Cu2(H2L2 )(H2O)(terpy)2] (terpy = 2,2&prime;:6&prime;,2&Prime;-terpyridine) (2). The crystal structure of 2 furnishes, for the first time, a picture of the coordination ability of Ins(1,2,3)P3 against a divalent metal ion. In addition, a PDB survey was performed on all InsPs to frame the coordination modes derived from our small-molecule supramolecular approach within a more realistic biological context.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?153a14c6db247331e65570aa180b886d5b96a92ab4ad43fe90c1e63d72b4b5d9ae6e54f4a751a2c5330486da71536f229af261b882d57e928628d47ec12c0895" target="_blank"><strong>Qui&ntilde;one, Delfina</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?5ad3267f4b4cb5190a6d9a3f5877923f528b6603e8a436c2005a31c5f35cd644629532a16ae958823cff6464fe03287baebd3b8724cc14f8d05da74957fe496d" target="_blank"><strong>Veiga, Nicol&aacute;s</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Savastano, Matteo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?750e9b353a1a0eefb2ebafb09948ec8ad0aaf80f89b11beeaec5c09b63f96eaba9e18ada7bbd99aa41fb5465563fac0dc417bfd7ca15c0e1b30c90239c1b2ecb" target="_blank"><strong>Torres, Julia</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bianchi, Antonio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?9e450ba14cecd9ab4f3eb3afee24db93c31091b76bdf313eaf4bb6f48e1aab267b159257e1da3edcf0943d49db8b33f104e170e20dcc8350cdee43a625f33f4e" target="_blank"><strong>Kremer, Carlos</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bazzicalupi, Carla</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[CrystEngComm, v.24, n&deg;11, 2022. -- pp. 2126-2137]]></dcterms:source>
    <dcterms:publisher><![CDATA[Royal Society of chemistry]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[12 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:bibliographicCitation><![CDATA[10.1039/d1ce01733k]]></dcterms:bibliographicCitation>
</rdf:Description></rdf:RDF>
