<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6803">
    <dcterms:title><![CDATA[<strong>Catalytic Mechanism of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[MYCOBACTERIUM TUBERCULOSIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TUBERCULOSIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[MICOBACTERIAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[MECANISMO CATALITICO]]></dcterms:subject>
    <dcterms:subject><![CDATA[QM/MM]]></dcterms:subject>
    <dcterms:subject><![CDATA[ENERGIA LIBRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[UMBRELLA SAMPLING]]></dcterms:subject>
    <dcterms:subject><![CDATA[METIONINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[SULFOXIDO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The oxidation of Met to methionine sulfoxide (MetSO) by oxidants such as hydrogen peroxide, hypochlorite, or peroxynitrite has profound effects on protein function. This modification can be reversed by methionine sulfoxide reductases (msr). In the context of pathogen infection, the reduction of oxidized proteins gains significance due to microbial oxidative damage generated by the immune system. For example, Mycobacterium tuberculosis (Mt) utilizes msrs (MtmsrA and MtmsrB) as part of the repair response to the host-induced oxidative stress. The absence of these enzymes makes Mycobacteria prone to increased susceptibility to cell death, pointing them out as potential therapeutic targets. This study provides a detailed characterization of the catalytic mechanism of MtmsrA using a comprehensive approach, including experimental techniques and theoretical methodologies. Confirming a ping-pong type enzymatic mechanism, we elucidate the catalytic parameters for sulfoxide and thioredoxin substrates (kcat/KM = 2656 &plusmn; 525 M&minus;1 s&minus;1 and 1.7 &plusmn; 0.8 &times; 106 M&minus;1 s&minus;1, respectively). Notably, the entropic nature of the activation process thermodynamics, representing &sim;85% of the activation free energy at room temperature, is underscored. Furthermore, the current study questions the plausibility of a sulfurane intermediate, which may be a transition-state-like structure, suggesting the involvement of a conserved histidine residue as an acid&minus;base catalyst in the MetSO reduction mechanism. This mechanistic insight not only advances our understanding of Mt antioxidant enzymes but also holds implications for future drug discovery and biotechnological applications.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[Sastre, Santiago]]></dcterms:creator>
    <dcterms:creator><![CDATA[Manta, Bruno.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Semelak, Jonathan A.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Estrin, Dario]]></dcterms:creator>
    <dcterms:creator><![CDATA[Trujillo Garr&eacute;, Madia]]></dcterms:creator>
    <dcterms:creator><![CDATA[Radi, Rafael]]></dcterms:creator>
    <dcterms:creator><![CDATA[Zei, Ari]]></dcterms:creator>
    <dcterms:source><![CDATA[ACS Publications]]></dcterms:source>
    <dcterms:publisher><![CDATA[Biochemistry, v.63, 2024. -- pp.533&minus;544]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<div class="element-text">
<div class="element-text">
<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
</div>
</div>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[12 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1021/acs.biochem.3c00504]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6802">
    <dcterms:title><![CDATA[<strong>Biosynthesis of ergosterol as a relevant molecular target of metal-based antiparasitic and antifungal compounds</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ERGOSTEROL]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIOSINTESIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIPARASITARIOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIFUNGICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[PRODUCTOS FARMACEUTICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[MEDICAMENTOS A BASE DE METALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Trypanosomatid parasites and fungi cause highly prevalent diseases. Ergosterol plays a crucial role in the structure and normal function of the membrane of these microorganisms. It is absent in mammals. Many enzymes of the ergosterol biosynthesis route have been recognized as molecular targets for drugs. Currently, a variety of organic drugs that interfere with sterol biosynthesis are employed to treat fungal infections, and some of them have been proposed as potential treatments for trypanosomiasis. Coordinating these organic drugs to metal ions may positively impact the biological performance by altering relevant physicochemical properties. Additionally, their organometallic derivatization could improve the effectiveness. This comprehensive review aims to highlight the considerable promise of metal-based compounds as inhibitors of essential pathways or key enzymes of these microorganisms, with focus on the ergosterol biosynthesis pathway. Additionally, bioactive metal compounds that have demonstrated experimental efficacy in acting on enzymes within this pathway although not designed for this purpose were included. The current state of the art demonstrates the impressive but still underexplored potential of these metal-based compounds for treating fungal and trypanosomatid infections.ERGOSTEROLBIOSINTESISANTIPARASITARIOSANTIGUNGICOSPRODUCTOS FARMACEUTICOSMEDICAMENTOS A BASE DE METALESBIBLIOGRAFIA NACIONAL QUIMICA2024]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Scalese, Gonzalo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mosquillo, Mar&iacute;a Florencia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez-D&iacute;az, Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gambino, Dinorah</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Coordination Chemistry Reviews, v.503, 2024. --]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[28 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.ccr.2023.215608]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6801">
    <dcterms:title><![CDATA[<strong>Biodiversity and brewing attitude of non-Saccharomyces strains isolated from Uruguayan vineyards and other ecosystems</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[LEVADURA NATIVAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[<p>STARMERELLA MELIPONINORUM</p>]]></dcterms:subject>
    <dcterms:subject><![CDATA[CONSUMO DE MALTOTRIOSA]]></dcterms:subject>
    <dcterms:subject><![CDATA[CERVEZAS BAJAS EN CARBOHIDRATOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[In recent years, interest in non-Saccharomyces yeasts for the innovation and development of different and alternative beer styles has been increasing, especially for the microbrewing industry. This work studied the biodiversity of non-Saccharomyces yeasts based on isolates from grapes of different Uruguayan vineyards, craft breweries and raw materials, with the aim of selecting autochthonous non-Saccharomyces yeasts with a brewing attitude. Brewing tests were performed on synthetic wort developed for this purpose, and the evolution of alcoholic fermentation was monitored by measuring glucose, maltose, maltotriose consumption, ethanol and glycerol production and final sensory analysis. A total of two hundred seventy-one yeast strains belonging to different genera were evaluated according to these parameters. After evaluating alcoholic fermentation performance, a native yeast strain belonging to the species Starmerella meliponinorum was selected due to its high maltotriose consumption and glycerol production, making it a very promising brewing yeast, especially for production of low carbohydrate beers.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Schinca, C.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, M.N.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carrau, F.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Medina, K.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[International Journal of Food Microbiology, v.412, 2024. -- e110529]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<div class="element-text">
<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
</div>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[10 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.ijfoodmicro.2023.110529]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6800">
    <dcterms:title><![CDATA[<strong>Formative research in teacher training: a case study carried out in Uruguay</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[URUGUAY]]></dcterms:subject>
    <dcterms:subject><![CDATA[DOCENTES]]></dcterms:subject>
    <dcterms:subject><![CDATA[ENSE&Ntilde;ANZA]]></dcterms:subject>
    <dcterms:subject><![CDATA[INVESTIGACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The importance of professionalism in teaching practices for achieving high-quality education has been acknowledged. Becoming a professional teacher is a long-term commitment but it is essential to promote high standards of professionalism from the beginning of teacher candidate formation. In addition, as professionalism in teaching is closely linked to the concept of &ldquo;teacher as a researcher&rdquo;, formative research seems to be a potent strategy for engaging future teachers in developing research abilities, essential for understanding and analyzing their educational practices. In this sense, the objective of this work is to explore the influence of a formative research approach on the development of research competencies by applying an action-research approach with a longitudinal cut. Thus, an intervention based on a ubiquitous strategy of formative research was implemented during the final three years of education of a teacher&rsquo;s training institution in Uruguay. The teacher candidate development of research competencies was assessed along the process. The obtained results demonstrated the effectiveness of implementing formative research to enhance the research skills of teacher candidates. The assessment of overall research competencies exhibited a statistically significant and substantial positive change (Cohen&rsquo;s d = 0.92). The impact was most pronounced among teacher candidates with the least developed initial research competencies, particularly for those in the early stages of their careers. This suggests that candidates engaged in the formative research strategy throughout their studies might achieve even higher levels of research competencies. Disaggregating the results by gender and for most of the specific subjects showed similar effects.In addition, within the framework of ubiquitous learning, the emphasis on the use of digital tools during the intervention led to an increase in the development of the research skills related to these tools for the studied sample. This is the first example of a quantitative approach that leads to concrete conclusions related to the effect of a research formative strategy for teacher candidates in Uruguay.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Imbert Romero, Daisy</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rebollo, Cristina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cabrera Borges, Claudia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>El&oacute;segui, Eduardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torres, Julia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Otero, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[International Journal of Educational Research v.125, 2024. -- e102345]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[12 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.ijer.2024.102345]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6799">
    <dcterms:title><![CDATA[<strong>Characterization of the immunosuppressive environment induced by larval Echinococcus granulosus during chronic experimental infection</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ECHINOCOCCUS GRANULOSUS]]></dcterms:subject>
    <dcterms:subject><![CDATA[MACROFAGO]]></dcterms:subject>
    <dcterms:subject><![CDATA[INMUNOSUPRESION]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The larval stage of Echinococcus granulosus causes the chronic infection known as cystic echinococcosis, deploying strong inhibitory mechanisms on host immune responses. Using experimental intraperitoneal infection in C57BL/6 mice, we carried out an in-depth analysis of the local changes in macrophage populations associated with chronic infection. In addition, we analyzed T cells and relevant soluble mediators. Infected animals showed an increase in local cell numbers, mostly accounted for by eosinophils, T cells, and macrophages. Within macrophage populations, the largest increases in cell numbers corresponded to resident large peritoneal macrophages (LPM). Monocyte recruitment appeared to be active, as judged by the increased number of monocytes and cells in the process of differentiation towards LPM, including small (SPM) and converting peritoneal macrophages (CPM). In contrast, we found no evidence of macrophage proliferation. Infection induced the expression of M2 markers in SPM, CPM, and LPM. It also enhanced the expression of the co-inhibitor PD-L1 in LPM, SPM, and CPM and induced the co-inhibitor PD-L2 in SPM and CPM. Therefore, local macrophages acquire M2-like phenotypes with probable suppressive capacities. Regarding T cells, infection induced an increase in the percentage of CD4+ cells that are PD-1+, which represent a potential target of suppression by PD-L1+/PD-L2+ macrophages. In possible agreement, CD4+ T cells from infected animals showed blunted proliferative responses to in vitro stimulation with anti-CD3. Further evidence of immune suppression in the parasite vicinity arose from the observation of an expansion in FoxP3+ CD4+ regulatory T cells and increases in the local concentrations of the anti-inflammatory cytokines TGF-&beta; and IL-1Ra.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Grezzi, Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mart&iacute;nez, Yamila E.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Barrios, Anabella A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>D&iacute;az, Alvaro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Casaravilla, Cecilia</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Infection and Immunity v. 92, n&deg;2, 2024]]></dcterms:source>
    <dcterms:publisher><![CDATA[American Society for Microbiology]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[19 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1128/iai.00276-23]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6798">
    <dcterms:title><![CDATA[<strong>In vitro antiviral activity of favipiravir and its 6- and 3-O-substituted derivatives against coronavirus: acetylation leads to improvement of antiviral activity</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ACETILACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[COVID 19]]></dcterms:subject>
    <dcterms:subject><![CDATA[FAVIPIRAVIR]]></dcterms:subject>
    <dcterms:subject><![CDATA[VIROLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Favipiravir is currently approved for the treatment of the influenza virus and has shown encouraging results in terms of antiviral capacity in clinical studies against severe acute respiratory syndrome coronavirus 2. Favipiravir is a prodrug, where its favipiravir‐ribofuranosyl‐5B‐triphosphate metabolite is capable of blocking RNA replication of the virus. However, the antiviral efficiency of favipiravir is limited by two factors: (i) low accumulation in plasma and rapid excretion/elimination postadministration and (ii) low conversion rate into the active metabolite. To tackle these problems, herein, we have designed new favipiravir analogues focusing on the replacement of the fluorine atom at the 6-position by halogen or hydrogen atoms and 3-O-functionalization with labile groups. The first type of functionalization seeks to increase the antiviral activity because of the better ability of the keto-tautomer as a function of the halogen, and it is hypothesized that the keto-tautomer tends to promote the formation of the ribofuranosyl-5B-triphosphate (RTP) metabolite. Meanwhile, the second type of functionalization seeks to promote lipophilicity and increase accumulation in cells. From the in vitro antiviral activity against two coronavirus models (bovine and human 229E), it was identified that the replacement did not improve the antiviral activity against both the models, which seems to be attributable to the low water solubility of these new 6-functionalized analogues. Meanwhile, with 3-O-functionalization, acetylation provided the most active compounds with higher half‐maximal inhibitory concentration and selectivity than favipiravir, whereas benzylation/methanosulfonation yielded the least active compounds. In summary, acetylation is found to be a convenient functionalization to enhance the antiviral profile of favipiravir.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Elizalde, Valeria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mirazo, Santiago</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Romero, Angel H.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Alvarez, Guzman</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Archiv der Pharmazie v. 357, n&deg;1, 2024]]></dcterms:source>
    <dcterms:publisher><![CDATA[Wiley]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[11 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1002/ardp.202300494]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6797">
    <dcterms:title><![CDATA[<strong>Processing methods for human amniotic membrane as scaffold for tissue engineering with mesenchymal stromal human cells</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CELULAS MADRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[CELULA ESTROMAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[DONANTES DE TEJIDOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. The aims of this work were to compare chemically and physically processed human Amniotic Membranes (hAM) and analyze the cytocompatibility and proliferation rate (PR) of two primary human mesenchymal stromal cell lines, from different sources and donor conditions seeded over these scaffolds. The evaluated hAM processes were: cold shock to obtain a frozen amniotic membrane (FEAM) with remaining dead epithelial cells, denudation of hAM with trypsin for 20/10 min (DEAM20/10) or treatment with sodium dodecyl sulfate to decellularized hAM (DAM). All samples were sterilized with gamma radiation. The selection of the treated hAM to then generate composites was performed by scanning and transmission electron microscopy and characterization by X-ray diffraction, selecting DEAM10 and FEAM as scaffolds for cell seeding. Two sources of primary human stromal cells were used, both developed by our researchers, human Dental Pulp Stem Cells (hDPSC) from living donors and human Mesenchymal Stromal Cells (hMSC) from bone marrow isolated from brain dead donors. This last line of cells conveys a novel source of human cells that, to our knowledge, have not been tested as part of this type of construct. We developed four in vitro constructs without cytotoxicity signs and with different PR depending on the scaffolds and cells. hDPSC and hMSC grew over both FEAM and DEAM10, but DEAM10 allowed higher PR.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Echarte, L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Grazioli, G.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pereira, L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Francia, A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez, H.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Kuzuian, W.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vicentino, W.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pardo, H.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mombr&uacute;, A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Maglia, &Aacute;.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Touri&ntilde;o, C.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>&Aacute;lvarez, I.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Cell and Tissue Banking v. 25, n&deg; 1, 2024. -- pp. 269-283]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[15 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1007/s10561-022-10014-8]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6796">
    <dcterms:title><![CDATA[<strong>Chemical reactivity of graphene doped with 3d transition metals: nothing compares to a single vacancy</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[GRAFENO]]></dcterms:subject>
    <dcterms:subject><![CDATA[MATERIALES 2D]]></dcterms:subject>
    <dcterms:subject><![CDATA[DOPAJE]]></dcterms:subject>
    <dcterms:subject><![CDATA[CATALISIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[REACTIVIDAD QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Context: Finding catalysts that do not rely on the use of expensive metals is one of the requirements to achieve sustainable production. The reactivity of graphene doped with 3d transition metals was studied. All dopants enhanced the reactivity of graphene and performed better than Stone&ndash;Wales defects and divacancies, but were inferior to monovacancies. For hydrogenation of doped-monovacancies, Sc, Ti, Cr, Co, and Ni induced more prominent reactivity on the carbon atoms. However, the metals were the most reactive center for V, Mn, and Fe-doped graphene. Cu and Zn turned the four neighboring carbon atoms into the preferred sites for hydrogenation. The addition of oxygen to doped graphene with Ti, V, Cr, Mn, Fe, Co, and Ni on a monovacancy revealed a more uniform pattern since the metal, preferred to react with oxygen. However, Sc induced a larger reactivity on the carbon atoms. The affinity of the 3d metal-doped graphene systems towards oxygen was inferior to that observed for single-vacancies. Therefore, vacancy engineering is the most favorable and least expensive method to enhance the reactivity of graphene. Methods: We applied Truhlar&rsquo;s M06-L method accompanied by the 6-31G* basis sets to perform periodic boundary conditions calculations as implemented in Gaussian 09. The ultrafine grid was employed and the unit cells were sampled employing 100 k-points. Results were visualized employing Gaussview 5.0.1.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Denis, Pablo A.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Molecular Modeling v. 30, n&deg;4, 2024.]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[10 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1007/s00894-024-05893-5]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6795">
    <dcterms:title><![CDATA[<strong>Graphenylene oxide : a new two-dimensional material</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[MATERIALES 2D]]></dcterms:subject>
    <dcterms:subject><![CDATA[NANOMATERIALES DE CARBONO]]></dcterms:subject>
    <dcterms:subject><![CDATA[TEORIA FUNCIONAL DE LA DENSIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[We investigated the oxidation and sulfurization of the graphenylene monolayer. Although this structure is unstable when it is 100 % covered with oxygen, obtaining a stable form of oxidized graphenylene is possible for 50 % of coverage. In this structure, the oxygen atoms are added on alternating sides of the monolayer, adopting an epoxy-like structure. It is stable up to 1635 K and is a minimum on the potential surface energy. It is an insulator with an indirect band gap of 5.3 eV, a value much larger than the band gap of the pristine graphenylene. Its sulfur counterpart is stable up to 1256 K, presenting a smaller indirect band gap of 3.5 eV.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Denis, Pablo A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Laranjeira,&nbsp;Jose A.S.&nbsp;</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>da Silva L. Fabris, Guilherme</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sambrano, Julio R.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Chemical Physics Letters v. 836, 2024. -- e141050]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[8 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.cplett.2023.141050]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6794">
    <dcterms:title><![CDATA[<strong>Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[IBOGAINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[SUE&Ntilde;O REM]]></dcterms:subject>
    <dcterms:subject><![CDATA[SUE&Ntilde;O]]></dcterms:subject>
    <dcterms:subject><![CDATA[PSICODELICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[EGG]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Ibogaine is a potent atypical psychedelic that has gained considerable attention due to its antiaddictive and antidepressant properties in preclinical and clinical studies. Previous research from our group showed that ibogaine suppresses sleep and produces an altered wakefulness state, which resembles natural REM sleep. However, after systemic administration, ibogaine is rapidly metabolized to noribogaine, which also shows antiaddictive effects but with a distinct pharmacological profile, making this drug a promising therapeutic candidate. Therefore, we still ignore whether the sleep/wake alterations depend on ibogaine or its principal metabolite noribogaine. To answer this question, we conducted polysomnographic recordings in rats following the administration of pure noribogaine. Our results show that noribogaine promotes wakefulness while reducing slow-wave sleep and blocking REM sleep, similar to our previous results reported for ibogaine administration. Thus, we shed new evidence on the mechanisms by which iboga alkaloids work in the brain.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Castro Nin, Juan Pedro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Serantes, Diego</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rodriguez, Paola</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonzalez, Bruno</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carrera, Ignacio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torterolo Minetti, Pablo Daniel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez Arbildi, Joaqu&iacute;n</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Psychopharmacology, 2024]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[10 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1007/s00213-024-06572-2]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6793">
    <dcterms:title><![CDATA[<strong>Pseudomonas violetae sp. nov. and Pseudomonas emilianonis sp. nov.: two new species with the ability to degrade TNT isolated from soil samples at Deception Island, maritime Antarctica</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANTARTIDA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BACTERIAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIORREMEDIACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Two motile, rod-shaped, Gram-stain-negative bacterial strains, TNT11T and TNT19T, were isolated from soil samples collected at Deception Island, Antarctica. According to the 16S rRNA gene sequence similarity, both strains belong to the genus Pseudomonas. Further genomic analyses based on ANI and dDDH suggested that these strains were new species. Growth of strain TNT11T is observed at 0&ndash;30 ℃ (optimum, 20 ℃), pH 4.0&ndash;9.0 (optimum, pH 6.0) and in the presence of 0&ndash;5.0% NaCl (optimum, 1% NaCl), while for TNT19T is observed at 0&ndash;30 ℃ (optimum between 15 and 20 ℃), pH 5.0&ndash;9.0 (optimum, pH 6.0) and in the presence of 0&ndash;5.0% NaCl (optimum between 0 and 1% NaCl). The fatty acid profile consists of the major compounds; C16: 0 and C16: 1 &omega;6 for TNT11T, and C16: 0 and C12: 0 for TNT19T. Based on the draft genome sequences, the DNA G + C content for TNT11T is 60.43 mol% and 58.60 mol% for TNT19T. Based on this polyphasic study, TNT11T and TNT19T represent two novel species of the genus Pseudomonas, for which the proposed names are Pseudomonas violetae sp. nov. and Pseudomonas emilianonis sp. nov., respectively. The type strains are Pseudomonas violetae TNT11T (= RGM 3443T = LMG 32959T) and Pseudomonas emilianonis TNT19T (= RGM 3442T = LMG 32960T). Strains TNT11T and TNT19T were deposited to CChRGM and BCCM/LMG with entry numbers RGM 3443/LMG 32959 and RGM 3442/LMG 32960, respectively.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Carrasco, Valentina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rold&aacute;n, Diego M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Valenzuela Ibaceta, Felipe</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lagos Moraga, Sebasti&aacute;n</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Dietz Vargas, Claudio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Menes, Rodolfo Javier</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez Donoso, Jos&eacute; M.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Archives of Microbiology v. 206, 2024]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[10 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1007/s00203-023-03768-6]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6792">
    <dcterms:title><![CDATA[<strong>Degradation study for 18650 NMC batteries at low temperature</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[BATERIAS DE LITIO-ION]]></dcterms:subject>
    <dcterms:subject><![CDATA[BATERIAS DE LITIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[ESTADO DE SALUD]]></dcterms:subject>
    <dcterms:subject><![CDATA[MECANISMO DE ENVEJECIMIENTO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[This research focuses on the identification and quantification of lithium-ion battery degradation indicators at low temperatures. We studied the cycling aging of 18,650 commercial NMC lithium-ion batteries at 10 ◦C. For this purpose, we carried out life cycle tests and performed Galvanostatic Intermittent Titration Technique (GITT) tests in the voltage range for the charge and discharge processes for different States of Health (SoH). The diffusion time constant and the ohmic overpotential were determined from GITT for different SoH. As the batteries degrade both parameters increase. A degradation mechanism associated with faradaic effects (increase in ohmic drop overpotential) and a thermodynamic effect associated with changes in the active material (diffusional time constant) is observed. Furthermore, we performed Electrochemical Voltage Spectroscopy studies through Incremental Capacity (IC) curves. IC curves peaks and valleys are associated with battery phase transformations due to aging phenomena. Each peak has a unique peak height, area, and position associated with a degradation mode. This research focuses on the IC curves derived from the discharge capacities at 3A and OCP (Open Circuit Potential) to study the thermodynamic and faradaic effects separately. The peak at 3.6 V and 3.4 V for the 3A and OCP studies, respectively, is the main feature for the detection of the degradation mechanism. The valley in the OCP curves intensifies with the decrease in SoH and is shifted to lower potentials, an effect that is not observed in the 3A curves. So, we could associate this with thermodynamic effects, Loss of Lithium Inventory (LLI) and Loss of Active Material (LAM) of both the positive electrode and the negative electrode.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Teliz, E.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>L&oacute;pez-V&aacute;zquez, C.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>D&iacute;az, V.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Electrochimica Acta, v.475, 2024. -- e143540]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[7 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[PDF]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.electacta.2023.143540]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6791">
    <dcterms:title><![CDATA[<strong>Labelling: control and radiopharmacological evaluation of 99mTc-adenisine 5'-diphosphate(99mTc-ADP) as tumour seeking agent.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[MARCADORES]]></dcterms:subject>
    <dcterms:subject><![CDATA[TECNECIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[RADIOFARMACOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[DETECCION DE TUMORES]]></dcterms:subject>
    <dcterms:subject><![CDATA[AGENTE TUMORAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[1996]]></dcterms:subject>
    <dcterms:abstract><![CDATA[A study of 99mTc-adenosine-5'-diphosphate (99mTc-ADP) as a radiopharmaceutical for tumour diagnosis is presented. Two different labelling methods, using SnCl2 in alkaline solution and Zn as reducing agents, were developed. Reduction with Sn(II) alkaline solution was the selected method because a lower concentration of ADP (0.5 mg/mL) could be used and a higher radiochemical yield was achieved. A labelled molecule with a radiochemical purity higher than 95%, in vitro stability of at least 6 hours and an over all negative charge was obtained Biodistribution studies carried out in normal mice and rats revealed rapid urinary excretion and no specific accumulation of activity in any other particular organ. This behaviour was similar to that reported for 99mTc-adenosine-5'-triphosphate (99mTc-ATP). Rapid blood clearance, that could be fitted to a bicompartimental model, was also verified. No evidence of in vivo instability was observed. Studies in mice and rats bearing spontaneous mammary adenocarcinomas were performed and the results were compared to those from the 99mTc-ATP studies. Although the tumour models used were not the same, the incorporation of both labelled compounds was very similar. Radioactivity uptake in the tumour and the tumour-to-blood ratio were not notably high. However, a significant increment was observed in the tumour-to-muscle ratio (1.0 +/- 0.2 at 30 minutes to 2.7 +/- 0.4 at 240 minutes). Whole-body autoradiography enabled tumour visualization. Further investigations, including scintigraphic imaging, must be carried to complete the clinical evaluation of 99mTc-ADP as a tumour seeking agent.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[Le&oacute;n, A.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Rey, A.M.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Savio, E.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Kremer, Carlos.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Lacava, C.J.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Nappa, A.N.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Chiozzone, R.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Campos, E.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Savio, E.]]></dcterms:creator>
    <dcterms:source><![CDATA[The Quarterly Journal of Nuclear Medicine v. 40, no. 2, 1996. -- p. 170-5]]></dcterms:source>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[6 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6790">
    <dcterms:title><![CDATA[<strong>Colesterol total y fracciones en mujeres embarazadas normales</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[DIABETES GESTACIONAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[RESISTENCIA INSULINICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[EMBARAZO]]></dcterms:subject>
    <dcterms:subject><![CDATA[COLESTEROL]]></dcterms:subject>
    <dcterms:subject><![CDATA[INDICE DE CASTELLI]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[1995]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<p>Se reportan laws variaciones del colesterol total y del HDL y no HDL colesterol, as&iacute; como el &Iacute;ndice de Castelli, en un estudio transversal realizado en intervalos de tiempo similares en mujeres embarazadas normales. Los datos provenientes de 210 mujeres embarazadas normales en diferentes estadios, se compararon con los de una poblaci&oacute;n de referencia de 30 mujeres normales no gr&aacute;vidas con edades similares. El colesterol HDL fue aislado con &aacute;cido fosfot&uacute;ngstico/cloruro de magnesio, el colesterol se determin&oacute; enzim&aacute;ticamente y el &Iacute;ndice de Castelli as&iacute; como el no HDL colesterol fueron calculados en cada caso. Nuestro objetivo es estudiar los cambios lip&iacute;dicos en esta poblaci&oacute;n de embarazadas con el prop&oacute;sito de establecer los valores de referencia e investigar si la gestaci&oacute;n podr&iacute;a estar relacionada a situaciones de riesgo cardiovascular. El HDL colesterol decreci&oacute; significativamente entre las semanas 24a y 28a, al tiempo que el &Iacute;ndice de Castelli alcanz&oacute; el m&aacute;ximo valor de riesgo. Desde este punto de vista se puede deducir que este proceso puede estar relacionado con el comienzo de la resistencia a la insulina y el mayor riesgo de aparici&oacute;n de diabetes gestacional.</p>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Raymondo, S.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Demiczlo, V.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pintos, C.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Acta Bioqu&iacute;mica Cl&iacute;nica Latinoamericana v. 29, no. 1, 1995. -- p. 85-91]]></dcterms:source>
    <dcterms:publisher><![CDATA[Federaci&oacute;n Bioqu&iacute;mica de la Provincia de Buenos Aires]]></dcterms:publisher>
    <dcterms:date><![CDATA[1995]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[7 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Espa&ntilde;ol]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6789">
    <dcterms:title><![CDATA[<strong>Impact of phenylalanine on Hanseniaspora vineae aroma metabolism during wine fermentation</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[SACCHAROMYCES]]></dcterms:subject>
    <dcterms:subject><![CDATA[FERMENTACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[CULTURAS MIXTAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BENCENO]]></dcterms:subject>
    <dcterms:subject><![CDATA[FENILPROPANOIDE]]></dcterms:subject>
    <dcterms:subject><![CDATA[NITROGENO ASIMILABLE]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Hanseniaspora vineae exhibits extraordinary positive oenological characteristics contributing to the aroma and texture of wines, especially by its ability to produce great concentrations of benzenoid and phenylpropanoid compounds compared with conventional Saccharomyces yeasts. Consequently, in practice, sequential inoculation of H. vineae and Saccharomyces cerevisiae allows to improve the aromatic quality of wines. In this work, we evaluated the impact on wine aroma produced by increasing the concentration of phenylalanine, the main amino acid precursor of phenylpropanoids and benzenoids. Fermentations were carried out using a Chardonnay grape juice containing 150 mg N/L yeast assimilable nitrogen. Fermentations were performed adding 60 mg/L of phenylalanine without any supplementary addition to the juice. Musts were inoculated sequentially using three different H. vineae strains isolated from Uruguayan vineyards and, after 96 h, S. cerevisiae was inoculated to complete the process. At the end of the fermentation, wine aromas were analysed by both gas chromatography– mass spectrometry and sensory evaluation through a panel of experts. Aromas derived from aromatic amino acids were differentially produced depending on the treatments. Sensory analysis revealed more floral character and greater aromatic complexity when compared with control fermentations without phenylalanine added. Moreover, fermentations performed in synthetic must with pure H. vineae revealed that even tyrosine can be used in absence of phenylalanine, and phenylalanine is not used by this yeast for the synthesis of tyrosine derivatives.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Valera, María José</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Olivera, Valentina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pérez, Gabriel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Boido, Eduardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Dellacassa, Eduardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carrau, Francisco</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[International Journal of Food Microbiology, v.415, 2024. -- e110631]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<div class="element-text">
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
</div>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[8 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Inglés]]></dcterms:language>
    <dcterms:type><![CDATA[Artículo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.ijfoodmicro.2024.110631]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6788">
    <dcterms:title><![CDATA[<strong>Influence of the emulsion type on phenytoin bioavailability&nbsp;</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[FENITOINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[EMULSIONES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIODISPONIBILIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLILOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[1994]]></dcterms:subject>
    <dcterms:abstract><![CDATA[To study the influence of the emulsion sign in phenytoin bioavailability two emulsions (w/o and o/w) were prepared. Bioavailability studies were carried out with both emulsions in Wistar male rats. The study was of a randomized two-way cross over design. A radiotracer technique was chosen as analytical procedure due to the small blood sample collected. 14C-phenytoin was synthesized with a high yield and suitable radiochemical purity. It is concluded from a biopharmaceutic point of view that the emulsion sign does not seem to affect the amount of phenytoin absorbed as it is shown through the comparison of the areas under curve up to 24 h. An emulsion with oil as an external phase is responsible of a longer absorption taking into account the apparent elimination constant rates.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Savio, E.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fagiolino, Pietro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Jelen, M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Le&oacute;n, A.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Bollettino Chimico Farmaceutico v. 133, no. 4, 1994. -- p. 239-245]]></dcterms:source>
    <dcterms:publisher><![CDATA[Societa editoriale farmaceutica]]></dcterms:publisher>
    <dcterms:date><![CDATA[1994]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[7 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6787">
    <dcterms:title><![CDATA[<strong>&lsquo;It's not something I really think about&rsquo;: Parents' perspectives and practices about how much food to offer in early childhood</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[NI&Ntilde;OS]]></dcterms:subject>
    <dcterms:subject><![CDATA[NI&Ntilde;EZ]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[NUTRICION]]></dcterms:subject>
    <dcterms:subject><![CDATA[SACIEDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[CANTIDAD DE ALIMENTOSAMBIENTE ALIMENTARIOBIBLIOGRAFIA NACIONAL QUIMICA2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Children are born with an innate capacity to self-regulate their energy intake, but cues from the food environment can undermine children's self-regulation, promoting overconsumption, and challenging energy balance. The size of the portion offered by parents and caregivers has been shown to be correlated with how much food children consume, which is known as the portion size effect. Furthermore, some parental feeding practices may interfere with children's ability to self-regulate. The present research explored parents' perspectives and practices about how much food they offer to their children in Uruguay. Forty-two in-depth interviews with parents of children between 6 months and 5 years old were conducted. Results showed that parental decisions about portion sizes for their children were mostly unconscious and intuitive. Parents were unconcerned about portion sizes, mainly due to the belief that children are able to self-regulate. Although parents identified themselves as mainly responsible for deciding how much food to serve their children, the majority reported to be responsive when their child refuses to eat or finish their meal, or when they request to eat more. Coercive feeding practices were only mentioned by a minority of parents.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Vidal, Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Brunet, Ger&oacute;nimo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Girona, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mach&iacute;n, Leandro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Curutchet, Mar&iacute;a R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>De Le&oacute;n, Carolina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ares, Gast&oacute;n</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Sensory Studies, v.39, 2024. -- e12917.]]></dcterms:source>
    <dcterms:publisher><![CDATA[Wiley]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<div class="element-text">
<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
</div>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[15 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1111/joss.12917]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6786">
    <dcterms:title><![CDATA[<strong>5-HT2A Receptor Knockout Mice Show Sex-Dependent Differences following Acute Noribogaine Administration</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[PSICODELICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[NORIBOGAINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[SEROTONINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[RECEPTORES DE GLUTAMATO]]></dcterms:subject>
    <dcterms:subject><![CDATA[GENES DE EXPRESION INMEDIATA TEMPRANA]]></dcterms:subject>
    <dcterms:subject><![CDATA[IEG]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Noribogaine (noribo) is the primary metabolite from ibogaine, an atypical psychedelic alkaloid isolated from the root bark of the African shrub Tabernanthe iboga. The main objective of this study was to test the hypothesis that molecular, electrophysiological, and behavioral responses of noribo are mediated by the 5-HT2A receptor (5-HT2AR) in mice. In that regard, we used male and female, 5-HT2AR knockout (KO) and wild type (WT) mice injected with a single noribo dose (10 or 40 mg/kg; i.p.). After 30 min., locomotor activity was recorded followed by mRNA measurements by qPCR (immediate early genes; IEG, glutamate receptors, and 5-HT2AR levels) and electrophysiology recordings of layer V pyramidal neurons from the medial prefrontal cortex. Noribo 40 decreased locomotion in male, but not female WT. Sex and genotype differences were observed for IEG and glutamate receptor expression. Expression of 5-HT2AR mRNA increased in the mPFC of WT mice following Noribo 10 (males) or Noribo 40 (females). Patch-clamp recordings showed that Noribo 40 reduced the NMDA-mediated postsynaptic current density in mPFC pyramidal neurons only in male WT mice, but no effects were found for either KO males or females. Our results highlight that noribo produces sexually dimorphic effects while the genetic removal of 5HT2AR blunted noribo-mediated responses to NMDA synaptic transmission.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Villalba, Sof&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Bruno</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Junge, Stephanie</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bernardi, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez Arbildi, Joaqu&iacute;n</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fag&uacute;ndez, Catherine</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torterolo Minetti, Pablo Daniel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carrera, Ignacio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Urbano, Francisco J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bisagno, Ver&oacute;nica</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[International Journal of Molecular Sciences, v.25. n&deg;2, 2024. --]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[18 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3390/ijms25020687]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6785">
    <dcterms:title><![CDATA[<p><strong>Unexpected high yield of acrolein underlies the importance of the</strong><br /><strong>hydrogen-abstraction mechanism in photooxidation of allyl methyl</strong><br /><strong>sulfide (AMS).</strong></p>]]></dcterms:title>
    <dcterms:subject><![CDATA[AZUFRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[ACROLEINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[HIDROGENO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[This work explores theoretically the gas phase oxidation of allyl methyl sulfide (AMS, H2C&ndash;&ndash; CHCH2SCH3) initiated by &bull;OH radicals, focusing on the H-abstraction pathway at the M06-2X-D3/aug-cc-pVTZ and MN15/ aug-cc-pVTZ levels of theory (m06Tz and mn15Tz). The formation of a prereactive complex (PRC) is involved in H-abstraction processes with two potential directions of approach for the OH radical, denoted as &ldquo;&alpha;&rdquo; and &ldquo;&beta;&rdquo;. The PRCs, demonstrate increased reactivity, primarily due to the interaction between the sulfur atoms and the hydroxyl hydrogen. A scheme for the H-abstraction mechanism that supports the experimentally identified products and predicts the formation of some S-containing low volatility products is proposed. The comparison of the potential energy surface (PES) between the double bond addition and H-abstraction paths in the AMS molecule shows that at the m06Tz level of theory, the H-abstraction on C3 and the addition to C1 have nearly the same profile of energy, while at the mn15Tz level, the minimum energy channel is the addition to C1. The theoretical rate coefficient for each reaction channel was calculated, considering the formation of a PRC prior to reaching the transition state of each channel and assuming thermal equilibrium between reactants and the PRC. The rate constants were calculated in a multi-TS/multi-conformer way at the SVECV-f12/m06Tz and SVECVf12/ mn15Tz levels of theory. The SVECV-f12 method is consistent in its predictions in both systems and exhibits only minor deviations from the experimental rate constants. Despite some specific differences due to the DFT method supporting the SVECV-f12 calculations, both methodologies predict a significant H-abstraction contribution in the AMS + OH gas phase reaction, which explains the high formation yield for acrolein determined experimentally.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Cardona, Alejandro L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Teruel, Mariano</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ventura, Oscar N.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Chemosphere v. 354, 2024. -- e141693]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[11 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.chemosphere.2024.141693]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6784">
    <dcterms:title><![CDATA[<strong>The adsorption/desorption behaviour of horseradish peroxidase heroxidase and porcine Thyroglobulin on concanavalin a-sepharose with different ligand densities</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ENZIMAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[LECTINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[PEROXIDASAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2000]]></dcterms:subject>
    <dcterms:abstract><![CDATA[A series of Concanavalin A-Sepharose gels containing between 5 and 480 mg lectin/g of dry gel was prepared by varying the amount of Concanavalin A used in the coupling reaction after activation with 1-cyano-4-(dimethyl-amino)-pyridinium tetrafluoroborate (CDAP) in a modified procedure. The influence of the ligand content on the adsorption / desorption of two different glycoproteins horseradish peroxidase (HRP Mw 40 KDa) and porcine thyroglogulin (Mw 670 KDa) was studied. The adsorption of HRP was found to be dependent on the ligand density and the largest amount adsorbed was obtained when the molar ratio between immobilized Con A and applied HRP was 9/1. The results indicate that highly effective lectin affinity adsorbents can be rationally designed based on the amounts of immobilized lectin]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Franco Fraguas, Laura</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Batista Viera, Francisco.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carlsson, J.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[International Journal of Bio/Chromatographyv. 5, no. 4, 2000. -- pp. 255-265]]></dcterms:source>
    <dcterms:publisher><![CDATA[Overseas]]></dcterms:publisher>
    <dcterms:date><![CDATA[2000]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[11 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6783">
    <dcterms:title><![CDATA[<strong>Coping strategies of food insecure households with children and adolescents in Uruguay, a high-income Latin American country: a qualitative study through the lens of Bourdieu&rsquo;s theories of capitals and practice</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[URUGUAY]]></dcterms:subject>
    <dcterms:subject><![CDATA[INSEGURIDAD ALIMENTARIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[POLITICAS PUBLICAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ADOLESCENTES]]></dcterms:subject>
    <dcterms:subject><![CDATA[NI&Ntilde;OS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Food insecurity has been associated with negative short, medium, and long-term health consequences, which are more detrimental for children and adolescents. These effects may depend on the coping strategies developed to deal with food shortages. The present research aimed at exploring coping strategies in food insecure households with children and adolescents in Uruguay, incorporating sociological theoretical insights from Bourdieu. A qualitative approach based on individual semi-structured interviews was used. A total of 40 interviews were conducted with adults who had parental responsibilities of children and adolescents and who received different types of food assistance, between July and December 2022, in four cities. Results showed that adults tend to develop a wide range of coping strategies aimed at: reducing food expenditure, increasing the availability of money for purchasing food, increasing food availability and/or rationing the food available in the household. Some of the strategies were implemented regardless of the severity of food insecurity, whereas others were characteristic of the moderate and severe levels of the construct. Evidence to support the mediation effect of coping strategies on health outcomes was found. Discourses suggested that lower accumulation of economic and cultural capital may be aligned with the adoption of less socially accepted mechanisms to access to food. Expressions of a specific habitus aimed at securing food were identified among participants with more deprivations. Taken together, the findings suggest that coping strategies may not be a universal or invariant sequence according to the severity of food insecurity and stress the importance of considering households&rsquo; resources and local context for the development of strategies to improve access to food.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Brunet, Ger&oacute;nimo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mach&iacute;n, Leandro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fajardo, Gabriela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bonilla, Luciana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa, Mar&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Fernanda</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bentancor, Silvia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Verdier, Sof&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Girona, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Curutchet, Mar&iacute;a Rosa</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pochell&uacute;, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cauci, Adriana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ares, Gast&oacute;n</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Appetite, v.198, 2024. -- e107383]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[12 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.appet.2024.107383]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6782">
    <dcterms:title><![CDATA[<strong>Optimization of emulsification conditions with rice bran concentrates for the preliminary formulation of potential vegan dressings and their characterization</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[SALVADO DE ARROZ]]></dcterms:subject>
    <dcterms:subject><![CDATA[EMULSIONES DE ACEITE]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[A fraction of rice bran (RB), generated during the brown rice polishing, is utilized to extract oil, resulting in defatted RB (DRB). The aim of this study was to optimize the emulsification conditions to enhance the value of this byproduct by formulating potential vegan dressings and characterizing them. Enzymatic hydrolysis of the starch present in DRB yields the DRB concentrate (DRBC). A central composite design was applied and the results were analyzed using response surface methodology to select optimal conditions for an oil-in-water emulsion formula. Two formulations were chosen: one corresponds to the optimal conditions, with 26.5% of oil and 73.5% of DRBC dispersion (eoptimal), and the other one with 21.7% of oil and 78.3% of dispersion (eED8). The eoptimal formulation exhibited significantly lowermean De Brouckere diameter (D4,3) value and higher viscosity when compared with eED8. For both emulsions, the particle size distribution and D4,3 remained unchanged during storage, whereas viscosity decreased, and backscattering (BS) increased. Initially, both emulsions exhibited solid viscoelastic behavior, whichwas partially lost during quiescent storage. The increase in BS was attributed to particle disaggregation, ultimately leading to the aforementioned change in rheological behavior. In conclusion, although the designed emulsions underwent microstructural changes, they were stable against gravitational separation. To improve stability during quiescent storage, it is suggested to incorporate a thickening agent. Hence, it is propose to procced with the development of a vegan dressing based on the eoptimal emulsion, as it exhibits superior physicochemical properties.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Bonifacino, Carla</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>L&oacute;pez, D&eacute;bora N.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Palazolo, Gonzalo G.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Panizzolo, Luis A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Abirached, Cecilia</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Food Science v.89, n&deg;4, 2024. -- pp. 2174-2187]]></dcterms:source>
    <dcterms:publisher><![CDATA[Wiley]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[14 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1111/1750-3841.17024]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6781">
    <dcterms:title><![CDATA[<strong>Solution-processed organic-inorganic hybrid material based on P3HT and SnS2 nanoparticles layers: synthesis and properties</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[NANOPARTICULAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[SULFURO DE ESTA&Ntilde;O]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Sn-based nanocomposites attract extensive attention as a new generation of photoelectric hybrid materials due to their high photoelectric conversion efficiency. In this work we synthesized SnS2 nanoparticles by a hydrothermal method employing citric acid (capping agent) and performed a capping agent exchange by pyridine to improve their solution processing and final properties. We fabricated layers with pyridine-capped nanoparticles and poly (3-hexylthiophene-2,5-diyl) (P3HT), employing the classical partial film sequence of a solar cell (ITO/PEDOT: PSS/P3HT:Nps). We found a &ldquo;coupling" between the nanoparticles and the polymer and highly ordered structures within the layers. The addition of nanoparticles improved the UV&ndash;vis absorption of P3HT and allowed the exploitation of the photoluminescence emission to promote extra charge carrier generation. Moreover, we found that SnS2_py nanoparticles form a nanoscopic mixture with the P3HT. Our pyridine-capped SnS2 nanoparticles are good candidates for fabricating hybrid materials, employing P3HT as the organic compound for application in polymeric-inorganic solar cells.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Bethencourt, Loengrid</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez Barthaburu, Mar&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Aguiar, Ivana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Oreggioni, Daniela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa de Santana, Ricardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>June Queiroz Maia, Lauro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gau, Daniel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Marotti, Ricardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fornaro, Laura</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Polymer v. 296, 2024. -- e126832]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[11 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.polymer.2024.126832]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6780">
    <dcterms:title><![CDATA[<strong>Spatio-temporal trends of mercury levels in alluvial gold mining spoils areas monitored between rainy and dry seasons in the Peruvian Amazon</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[PERU]]></dcterms:subject>
    <dcterms:subject><![CDATA[AMAZONIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[CONTAMINACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[MINERIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Artisanal and small-scale gold mining (ASGM) in the Amazon has degraded tropical forests and escalated mercury (Hg) pollution, affecting biodiversity, ecological processes and rural livelihoods. In the Peruvian Amazon, ASGM annually releases some 181 tons of Hg into the environment. Despite some recent advances in understanding the spatial distribution of Hg within gold mine spoils and the surrounding landscape, temporal dynamics in Hg movement are not well understood. We aimed to reveal spatio-temporal trends of soil Hg in areas degraded by ASGM.,. We analyzed soil and sediment samples during the dry and rainy seasons across 14 ha of potentially contaminated sites and natural forests, in the vicinities of the Native community of San Jacinto in Madre de Dios, Peru. Soil Hg levels of areas impacted by ASGM (0.02 &plusmn; 0.02 mg kg]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Becerra Lira, Edwin</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rodriguez Achata, Liset</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mu&ntilde;oz Ush&ntilde;ahua, Adenka</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Corvera Gomringer, Ronald</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Thomas, Evert</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Garate Quispe, Jorge</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Hilares Vargas, Litcely</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Romel Nascimento Herbay, Pedro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gamarra Miranda, Luis Alfredo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Umpi&eacute;rrez, Eleuterio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Guerrero Barrantes, Juan Antonio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pillaca, Martin</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cusi Auca, Edgar</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pe&ntilde;a Valdeiglesias, Joel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Russo, Ricardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>del Castillo Torres, Dennis</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Velasquez Ram&iacute;rez, Manuel Gabriel</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Environmental Research v.245, 2024. -- e118073]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[9 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.envres.2023.118073]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6779">
    <dcterms:title><![CDATA[Assessment of the performance of the body mass index in diagnosing obesity in community-dwelling older adults in Latin American and Caribbean countries]]></dcterms:title>
    <dcterms:subject><![CDATA[OBESIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[INDICE DE MASA CORPORAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPOSICION CORPORAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[ADULTOS MAYORES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Background: The body mass index (BMI) &ge;30 kg/m2 is the universally accepted cut-off point for defining obesity; however, its accuracy in classifying obesity in older adults is poorly understood. Objectives: To assess the performance of the BMI cut-off point &ge;30 kg/m2 in classifying obesity in older adults, using the fat mass index (FMI) and fat mass percentage (FM%) as reference criteria; and to establish region- and sex-specific BMI-based cut-off points to classify obesity in older adults. Methods: The present study is a secondary analysis derived from a cross-sectional project that included a sample of 1463 older adults from ten Latin American and Caribbean countries. Volunteers underwent total body water measurements using the deuterium dilution technique to determine FMI and FM%. Accuracy of the BMI and derived cutoff points was assessed by the area under the receiver operating characteristic curve (AUC).Results: The BMI cut-off point &ge;30 kg/m2 had low sensitivity for classifying obesity in these older adults compared to the FMI and FM%. The AUC values for the optimal BMI-derived cut-off points showed an acceptable-to-outstanding discriminatory capacity in diagnosing obesity defined by the FMI. There was also a better balance between sensitivity and specificity than with the values obtained by a BMI &ge;30 kg/m2 in older subjects in both regions. Conclusion: The BMI cut-off point &ge;30 kg/m2 had poor sensitivity for accurately diagnosing obesity in older adults from two regions. The region- and sex-specific BMI-derived cut-off points for defining obesity using the FMI are more accurate in classifying obesity in older men and women subjects from both regions.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[Alem&aacute;n Mateo, Heliodoro]]></dcterms:creator>
    <dcterms:creator><![CDATA[L&oacute;pez Teros, Miriam T.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Pallaro, Anabel Nora]]></dcterms:creator>
    <dcterms:creator><![CDATA[M&aacute;rquez, Carlos]]></dcterms:creator>
    <dcterms:creator><![CDATA[Quintana Guzm&aacute;n, Eugenia Mar&iacute;a]]></dcterms:creator>
    <dcterms:creator><![CDATA[Ram&iacute;rez Zea, Manuel]]></dcterms:creator>
    <dcterms:creator><![CDATA[D&iacute;az S&aacute;nchez, Mar&iacute;a Elena]]></dcterms:creator>
    <dcterms:creator><![CDATA[Umpi&eacute;rrez, Eleuterio]]></dcterms:creator>
    <dcterms:creator><![CDATA[Moirano, Marina]]></dcterms:creator>
    <dcterms:creator><![CDATA[Badaloo, Asha]]></dcterms:creator>
    <dcterms:creator><![CDATA[Rodriguez O&rsquo;Donnell, Ada]]></dcterms:creator>
    <dcterms:creator><![CDATA[Murphy Alford, Alexia J.]]></dcterms:creator>
    <dcterms:creator><![CDATA[Ferrioli, Eduardo]]></dcterms:creator>
    <dcterms:source><![CDATA[Archives of gerontology and geriatrics v. 116, 2024. -- e105170]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[9 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.archger.2023.105170]]></dcterms:identifier>
</rdf:Description></rdf:RDF>
