The Influence of Cardiovascular Physiology on Dose/Pharmacokinetic and Pharmacokinetic/ Pharmacodynamic Relationships

]]> Fagiolino, Pietro]]> Eiraldi, Rosa]]> Vázquez, Marta]]> Información sobre Derechos de Autor
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La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)
ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Characterisation of the Native Lipid Moiety of Echinococcus granulosus Antigen B

]]> Obal, Gonzalo]]> Ramos, Ana Lía]]> Silva, Valeria]]> Lima, Analía]]> Batthyany, Carlos]]> Bessio, María Inés]]> Ferreira Chiesa, Fernando]]> Salinas, Gustavo]]> Ferreira, Ana María]]> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ]]> ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Essential oil yield and composition of Lamiaceae species growing in Southern Brazil

]]> Agostini, Fabiana]]> Santos, Ana Cristina Atti dos]]> Rossato, Marcelo]]> Pansera, M.R.]]> Santos, Paula Luciana dos]]> Serafini, Luciana A.]]> Molon, Rosangela]]> Moyna, Patrick]]> Información sobre Derechos de Autor

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La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

]]> Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs

]]> Ancizu, Saioa]]> Moreno, Elsa]]> Torres, Enrique]]> Burguete, Asunción]]> Pérez-Silanes, Silvia]]> Benítez, Diego]]> Villar, Raquel]]> Solano, Beatriz]]> Marín, Adoración]]> Aldana, Ignacio]]> Cerecetto, Hugo]]> González Hormaizteguy, María Mercedes]]> Monge, Antonio]]> Comparison of attribute liking and Jar scales to evaluate the adequacy of sensory attributes of milk desserts

]]> Ares, Gastón

]]> Barreiro, Cecilia]]> Giménez, Ana]]> Información sobre Derechos de Autor

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(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.

]]> Consumers' texture perception of milk desserts. I. Relationship with rheological measurements]]> Ares, Gastón]]> Budelli, E.]]> Bruzzone, Fernanda]]> Giménez, Ana]]> Lema, Patricia]]> Información sobre Derechos de Autor

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]]> Consumer perceived healthhiness and willingness to try functional milk desserts : Influence of ingredient, ingredient name and health claim

]]> Ares, Gastón]]> Giménez, Ana]]> Gámbaro García, Adriana]]> Información sobre Derechos de Autor

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]]> Alternatives to reduce the bitterness, astringency and characteristic flavour of antioxidant extracts

]]> Ares, Gastón]]> Barreiro, Cecilia]]> Deliza, Rosires]]> Gámbaro García, Adriana]]> Información sobre Derechos de Autor

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La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

]]> Ultra-sensitive electrochemical immunosensor using analyte peptidomimetics selected from phage display peptide libraries]]> Arévalo, Fernando Javier]]> González Techera, Andrés]]> Zon, María Alicia]]> González-Sapienza, Gualberto G.]]> Fernández, Héctor]]> Información sobre Derechos de Autor

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]]> Tandem repeat-tRNA (TRtRNA) PCR method for the molecular typing of non-Saccharomyces subspecies]]> Barquet, Marianne]]> Martín Valverde, Antonio]]> Medina, Karina]]> Perez, Gabriel]]> Carrau, Francisco]]> Gaggero de Munno, Carina]]> Información sobre Derechos de Autor

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]]>

]]> New achievements on biological aspects of copper complexes Casiopeínas: Interaction with DNA and proteins and anti-Trypanosoma cruzi activity

]]> Becco Sierra, Lorena Lourdes]]> Rodríguez, Alejandra]]> Bravo, María Elena]]> Prieto, María José]]> Ruiz Azuara, Lena]]> Garat, Beatriz]]> Moreno, Virtudes]]> Gambino, Dinorah]]> Información sobre Derechos de Autor

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]]> Effect of complexation of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides with palladium and copper on their anti-T. Cruzi activity

]]> Benítez, Diego]]> Lavaggi, Marìa Laura]]> Gambino, Dinorah]]> Torre, María H.]]> Cerecetto, Hugo]]> González Hormaizteguy, María Mercedes]]> Información sobre Derechos de Autor

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]]>

]]> New functional fibre in milk puddings : effect on sensory properties and consumers`acceptability]]> The effect of the addition of a new functional fibre (high-amylose maize starch, HAMS, as a source of resistant starch), recently available in the market, on sensory characteristics and consumers' acceptability of milk puddings was studied. Milk puddings containing modified waxy maize starch and κ-carrageenan were produced with different HAMS concentrations (0, 1, 2, 3 and 4%). Higher HAMS concentration caused changes in the sensory characteristics of milk puddings. Particularly, sensory attributes such as some roughness, rough afterfeel and floury taste appeared. Besides, the addition of HAMS caused an increase in manual and oral thickness and a decrease in creaminess, melting, and sweetness. A HAMS enrichment level of 1.4% in this product was estimated as the maximum concentration that does not significantly modify consumers' overall acceptability. Using survival analysis the proportion of consumers who would buy milk desserts containing 1.4 % HAMS was estimated as 71%. Consumers more interested in consuming functional foods enriched with fibre were more tolerant to the sensory changes caused by the addition of HAMS to the milk puddings.

]]> Ares, Gastón]]> Baixauli, Raquel]]> Sanz, Teresa]]> Varela, Paula]]> Salvador, Ana]]> Información sobre Derechos de Autor

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]]> Development of a sensory quality index for strawberries based on correlation between sensory data and consumer perception

]]> The aim of the present work was to develop asensory qualityindex for the appearance and odour of strawberries based on consumerperception. Six samples of strawberries with different degrees of ripeness and deterioration were evaluated by a trained sensory panel and aconsumer panel. Using principal component analysis, the sensory quality of strawberries was defined by two indices, one related to the sensory deterioration and another related to the intensity of desirable sensory attributes. As expected, consumer acceptability and intention to purchase strawberries decreased as sensory deterioration index increased and desirable attributes index decreased. Asensoryqualityindex was calculated by correlating consumer acceptability scores with the aforementioned indices. This index allows objective evaluation of the sensoryquality of strawberries using a trained assessors panel. Limits for this index could be used in quality control programs or to estimate sensory shelf life of strawberries. The methodology applied in the present work could be applied to other products in order to develop appropriate sensory quality indices based on consumer perception.

]]> Ares, Gastón]]> Barrios, Sofía]]> Lareo, Claudia]]> Lema, Patricia]]> Información sobre Derechos de Autor

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]]> Consumers´texture perception of milk desserts. II. Comparison with trained assessors´data

]]> Considering the importance of texture in consumers’ acceptance of many dairy products, particularly milk desserts, it is important to rely on methodologies to understand consumers’ texture perception.The aim of the presentwork was to study the relationship between consumers’ texture perception of milk desserts and trained assessors’ data. Six commercial milk desserts were evaluated by a panel of 100 consumers, divided into two groups of 50, which evaluated the texture of the desserts using intensity scales for five texture attributes or a check-all-that-apply question. Concurrently, seven texture attributes of the desserts were evaluated by a trained panel. Results showed that both consumer profiling methodologies were able to identify differences in the texture characteristics of the desserts, providing very similar sensory maps.High correlation between textural attributes evaluated by consumers and trained assessors was found, indicating that consumers were able to evaluate the attributes in a similar way as trained assessors did.

]]> Bruzzone, Fernanda]]> Ares, Gastón]]> Giménez, Ana]]> Información sobre Derechos de Autor

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]]> Origin of Epilachna paenulata defensive alkaloids : Incorporation of [1-13C]-sodium acetate and [methyl-2H3]-stearic

]]> Ladybird beetles produce a large number of defensive alkaloids. Previous studies suggest that the structural diversity of these endogenous alkaloids can be traced to a common biosynthetic route based on the condensation of several acetate units. In this study, adults of Epilachna paenulata, a phytophagous neotropical species, were fed on diet enriched with potential precursors (sodium acetate, fatty acids and the amino acids lysine and ornithine) labeled with stable isotopes (13C, 2H and 15N). Labeled acetate was incorporated into the structurally related homotropane and piperidine alkaloids. The later also showed incorporation of [methyl-2H3] stearic acid. Our results hence support a fatty acid pathway for the biosynthesis of E. paenulata alkaloids. To our knowledge, this is the first report on the incorporation of a labeled fatty acid into a defensive piperidine alkaloid in insects

]]> Camarano, Soledad]]> González, Andrés]]> Rossini, Carmen]]> Información sobre Derechos de Autor

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]]> Synthesis and spectroscopic characterization of hydroxylamido/amino acid complexes of oxovanadium (V)]]> A series of mixed ligand oxovanadium(V) complexes of the type [VO(NH2O)2(aa)], containing the hydroxylamido ligand and simple amino acids, were prepared and characterized. Seven of these complexes, with aa = valine, leucine, isoleucine, phenylalanine, tryptophan, cysteine and methionine, were described for the first time. Their infrared and Raman spectra, together with those of the previously investigated similar species with aa = glycine, serine, threonine and alanine, and those of the related [VO(NH2O)2(imidazole)2]Cl complex, were recorded and assigned. The spectroscopic behavior of the new complexes is similar to that of the other five, whose structures has been determined by X-ray crystallography, suggesting an identical structure for the full series of complexes. The spectroscopic results also give a better characterization of the vibrational behavior of the interesting O–N–“side-on” bonded hydroxylamido ligand.

]]> Arrambide, Gabriel]]> Baran, Enrique J.]]> Gambino, Dinorah]]> Información sobre Derechos de Autor

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]]> Impacts of multidisciplinary actions on environmental lead exposure in Uruguay]]> 2.11.0.0]]> 2.11.0.0]]> 2.11.0.0]]> 2.11.0.0]]> 2.11.0.0]]> Environmental lead contamination in Uruguay became a matter of public concern in 2001, when cases of children with blood lead levels (BLL) higher than 20 lg/dl appeared in some low-income neighborhoods of Montevideo, being 10 lg/dl the intervention reference BLL. The aim of this paper is to show the results of multidisciplinary actions taken by decisions makers in social, environmental and healthcare aspects, to minimize lead exposure risks. We evaluated changes in blood lead levels of different children and non-exposed adult populations before and after the actions were taken, from 2001 on. For children populations and non-exposed adults, we found a significant decrease of almost 50% in BLL compared with studies done before the actions were taken. The main action to consider was the phasing out process of leaded gasoline in our country among other. We conclude that the integration of inter and multidisciplinary actions promoted was of high impact on the population, bringing about a public sensitization and growing awareness of the lead environmental risks.

]]> Cousillas, Adriana Z. ]]> Pereira, Laura ]]> Heller, Teresa ]]> Alvarez, Maria Cristina ]]> Mañay, Nelly ]]> 2.11.0.0]]> 2.11.0.0]]> 2.11.0.0]]> Información sobre Derechos de Autor

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]]> 2.11.0.0]]> 2.11.0.0]]> 2.11.0.0]]> 2.11.0.0]]> 2.11.0.0]]> Spectroscopic behavior and biological activity of K3[VO(=2)2CO3]H2O]]> The potassium salt of the carbonato oxodiperoxovanadate(V) complex, obtained by a known synthetic procedure, was thoroughly characterized by infrared, Raman, and electronic spectroscopy. The bioactivity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. At low doses, the complex is more toxic for the nontransformed osteoblasts than for the tumoral ones, whereas at higher doses the deleterious effects are similar for both cell lines. This peroxo complex seems to be the most toxic compound that has so far been tested on osteoblast-like cells in culture.

]]> Arrambide, Gabriel]]> Rivadeneira, Josefina]]> Etcheverry, Susana B.]]> Parajón-Costa, Beatriz Susana]]> Gambino, Dinorah]]> Baran, Enrique J.]]> Información sobre Derechos de Autor

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]]> New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands : potential anti-trypanosomal agents]]> In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasites, and particularly against African Trypanosomiasis, whose etiological agent is Trypanosoma brucei, organoruthenium compounds with bioactive nitrofuran containing thiosemicarbazones (L) as co-ligands were obtained. Four ruthenium(II) complexes with the formula [Ru2(p-cymene)2(L)2]X2, where X = Cl or PF6, were synthesized and the crystal structures of two of them were solved by X-ray diffraction methods. Two of the complexes show significant in vitro growth inhibition activity against Trypanosoma brucei brucei and are highly selective towards trypanosomal cells with respect to mammalian cells (J774 murine macrophages). These promising results make the title organoruthenium compounds good lead candidates for further developments towards potential antitrypanosomal organometallic drugs.

]]> Demoro, Bruno]]> Sarniguet, Cynthia]]> Sanchez-Delgado, Roberto]]> Rossi, Miriam]]> Liebowitz, Daniel]]> Caruso, Francesco]]> Olea-Azar, Claudio]]> Moreno, Virtudes]]> Medeiros, Andrea]]> Comini, Marcelo]]> Otero Zubiaurre, Ana Lucía]]> Información sobre Derechos de Autor

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]]>

]]> Chemical reactivity of lithium-doped fullerenes]]> The addition of free radicals and the 1,3 dipolar cycloaddition onto pristine and lithium-doped C60 were studied by means of the Perdew–Burke–Ernzerhof (PBE) and M06-2X density functionals. In all cases, lithium increased the reactivity even though for the 1,3 dipolar cycloaddition onto C60 the change observed with respect to bare C60 was minimal. Both functionals employed gave similar encapsulation energies for Li@C60 namely, 33.1 and 38.2kcal/ mol at the PBE/6-31G* and M06-2X/6-31G*, respectively. However, the increased reactivity because of lithium doping determined at the PBE level is smaller as compared with that computed with the M06-2X functional, whereas that determined at the second-order Møller–Plesset (MP2) level is the largest one. For example, using the M06-2X functional the binding energy of fluorine to Li@C60 is 28.5kcal/mol larger than that determined for C60, whereas at the PBE/6-31G* level it is predicted to be increased by 24.7kcal/mol. The results clearly suggest that Li@C60 is a much better free radical scavenger than C60. Finally, the complex hindered rotations of lithium inside C60 are expected to be strongly inhibited because lithium doping increases the well depth between the cage center and the equilibrium position near the addition site of the lithium atom.

]]> Denis, Pablo A.]]> Información sobre Derechos de Autor

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]]> Evaluation of the essential oils from nine basil (Ocimum basilicum L.) cultivars planted in Southern Brazil]]> The goal of the present work was to establish the essential oil yields and chemical compositions of nine Basil (Ocimum basilicum L.) cultivars. The plants were grown in the fields, in an averaged experimental design, using ten plants of each of the nine cultivars in each parcel, making three repeats of each experiment. The parameters measured were fresh and dry weight of the aerial parts, yield and chemical compositions of the essential oils. The yields ranged from 6.21 to 42.51 L/ha, the Genovese cultivar being the most productive. The chemical composition of all cultivars had high contents of linalool, with the highest being that of the Toscano "lettuce leave" cultivar.

]]> Atti-Serafini, L.]]> Pauletti, G. F.]]> Rota, L. D.]]> Dos Santos, A. C. A.]]> Agostini, F.]]> Zattera, F.]]> Moyna, Patrick]]> Información sobre Derechos de Autor

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ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.

]]> Vibrational spectra of the physiologically and pharmacologically relevant Cu(L-His)2 complex]]> The infrared spectrum of the Cu(II) complex of L-histidine (L-His) of composition [Cu(LHis) 2].1.5 H2O, generated at physiological conditions, was recorded and analyzed in relation to its structural peculiarities and by comparison with the spectrum of the free amino acid. The electronic spectrum of the complex is also briefly discussed

]]> Baran, E. J.]]> Torre, M. H.]]> Información sobre Derechos de Autor

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]]> Enantiospecific synthesis and insect feeding activity of sulfur-containing cyclitols]]> The first syntheses of two deoxythiocyanocyclitols (4-deoxy-4-thiocyano-L-chiro-inositol and deoxythiocyanoconduritol F) and two deoxysulfonylcyclitol acetals are reported by a chemoenzymatic enantioselective route. The compounds were prepared by a sequence of enzymatic and ruthenium-catalyzed dihydroxylations, and the results were studied regarding reaction conditions and co-catalyst for different derivatives. The new compounds were included in a minilibrary of deoxygenated cyclitols and evaluated for their capacity to influence the feeding behavior of Epilachna paenulata (Coleoptera: Coccinellidae), a common pest of the Curcubitaceae crops.

]]> Bellomo, Ana

]]> Camarano, Soledad

]]> Rossini, Carmen.]]> González, David]]> Información sobre Derechos de Autor

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]]> Chemoenzymatic synthesis of glycosyl-deoxyinositol derivatives. First example of a fagopyritol B-analogue containing an aminoinositol unit

]]> The first synthesis of two fagopyritol β-analogues (β-d-galactopyranosyl-(1′→1)-conduramine F-4 and β-d-galactopyranosyl-(1′→3)-4-aminodeoxy-l-chiro-inositol) has been accomplished by a chemoenzymatic route in satisfactory yields. The key step of the synthesis is the TMSOTf-promoted glycosylation reaction of a deoxyconduritol derivative. The methodology is amenable to scale-up and expandable to the preparation of other pseudofagopyritols.

]]> Bellomo, Ana

]]> Bonilla, Julia B.

]]> López-Prados, Javier

]]> Martín Lomas, Manuel

]]> González, David

]]> Información sobre Derechos de Autor

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]]>