<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/1625">
    <dcterms:title><![CDATA[<strong>In silico nanobio-design. A new frontier in computational biology</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[BIOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPUTACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2007]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Nanobiology is a fast-emerging discipline that brings the tools of nanotechnology to the biological sciences. The introduction of new techniques may accelerate the development of highly specific biomedical treatments, increase their efficiency, and minimize their side effects. Introducing foreign bodies into the complex machinery of the human body is, however, a great and humbling challenge, as past experience has shown. In order for nanobiology to reach its full potential, we must devise a means to alter the properties of nanoparticles, as expressed in the human body, in a predictable manner. Computer-aided methods are the natural option to speed up the development of these technologies. Yet, the procedures for annotation and simulation of nanoparticle properties must be developed and their limitations understood before computational methods can be fully exploited. In this review we will compare the state of development of nanoscale simulations in the biological sciences to that of the computer-aided drug design efforts in the past, tracing a historical parallel between both disciplines. From this comparison, lessons can be learned and bottlenecks identified, helping to speed up the development of computer-aided nanobiodevice design tools]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Cachau, Ra&uacute;l E.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonzalez-Nilo, Fernando</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=40f23b501897bd535c01b6602f1ea346" target="_blank"><strong>Ventura, Oscar N.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fritts, Mart&iacute;n J.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Current Topics in Medicinal Chemistry v. 7, no. 15, 2007. -- p. 1537-40]]></dcterms:source>
    <dcterms:publisher><![CDATA[Bentham Science]]></dcterms:publisher>
    <dcterms:date><![CDATA[2007]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingles]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI:10.2174/156802607782194680]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/675">
    <dcterms:title><![CDATA[<strong>In silico studies of Echinococcus granulosus FABPs</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[PROTEINAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ECHINOCOCCUS GRANULOSUS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2013]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Fatty acid (FA) binding proteins are small intracellular proteins whose members exhibit great diversity and low similarity at the primary structure level, but a highly conserved three-dimensional structure. Characterised by a high-affinity non-covalent binding of hydrophobic ligands, these proteins have a molecular mass of 14&ndash;15&thinsp;kDa with a characteristic &beta;-barrel structure. Members of this family have been identified along the zoological scale, with Platyhelminthes being the more primitive organisms where they have been reported. Two FA binding proteins (FABPs), EgFABP1 and EgFABP2, with 88% similarity have been identified in Echinococcus granulosus. In an effort to understand why two such similar proteins are expressed by this organism, we performed an in silico analysis of the binding capabilities of both proteins. The crystallographic structure of EgFABP1 was utilised as a template to model EgFABP2, and both were docked against palmitate, oleate, linoleate and arachidonate. The docked structures were submitted to 4&thinsp;ns molecular dynamics simulations, and their protein&ndash;ligand interaction energies were measured. The collected data demonstrated that linoleate and arachidonate had the higher interaction energies when bound to EgFABP1 and that palmitate and linoleate had the higher interaction energies when bound to EgFABP2. External and internal binding surfaces were analysed, showing differences at both levels. Internal surface compositions suggested that both proteins could have preferences for certain FAs. Comparisons of the holo and apo forms of each protein indicated that the ligand imposed subtle, but specific modifications that could trigger surface signals. The differences found between the proteins under study suggest that they could have functional uniqueness in the parasite's metabolism.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Estevez, Adriana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2e3c62395a54ce79c86b7e4fa4b5c3f9" target="_blank"><strong>Paulino Zunini, Margot</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Biomolecular Structure and Dynamics&nbsp; v. 31, no. 2, 2013. -- p. 224-239]]></dcterms:source>
    <dcterms:publisher><![CDATA[Taylor and Francis]]></dcterms:publisher>
    <dcterms:date><![CDATA[2013]]></dcterms:date>
    <dcterms:rights><![CDATA[<p>&nbsp;</p>
<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
<p>&nbsp;</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1080/07391102.2012.698246]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/5311">
    <dcterms:title><![CDATA[<strong>In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[NITRACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[ACIDO LINOLEICO]]></dcterms:subject>
    <dcterms:subject><![CDATA[MACROFAGOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2018]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated linoleic acid (NO2-CLA). Herein, NO2-CLA generation is demonstrated within the context of acute inflammatory responses both in vitro and in vivo. Macrophage activation resulted in dose- and time-dependent CLA nitration and also in the production of secondary electrophilic and non-electrophilic derivatives. Both exogenous NO2-CLA as well as that generated in situ, attenuated NF-&kappa;B-dependent gene expression, decreased pro-inflammatory cytokine production and up-regulated Nrf2-regulated proteins. Importantly, both CLA nitration and the corresponding downstream anti-inflammatory actions of NO2-CLA were recapitulated in a mouse peritonitis model where NO2-CLA administration decreased pro-inflammatory cytokines and inhibited leukocyte recruitment. Taken together, our results demonstrate that the formation of NO2-CLA has the potential to function as an adaptive response capable of not only modulating inflammation amplitude but also protecting neighboring tissues via the expression of Nrf2-dependent genes.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Villacorta, Luis</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Minarrieta, Luc&iacute;a.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Salvatore, Sonia R</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Khoo, Nicholas K.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rom, Oren</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gao, Zhen</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Berman, Rebecca C.<br /></strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Jobbagy, Soma</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Li, Lihua</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Woodcock, Steven R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Chen, Y. Eugene</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Freeman, Bruce A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ferreira, Ana Mar&iacute;a.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Schopfer, Francisco J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vitturi, Dar&iacute;o A.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Redox Biology&nbsp; v. 15, 2018. -- p. 522-531]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2018]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong> ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI：201802236228518168]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/4769">
    <dcterms:title><![CDATA[<strong>In situ growth of ceramic quantum dots in polyaniline host via water vapor flow diffusion as potential electrode materials for energy applications</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[NANOTECNOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[CERAMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[NANOCOMPUESTO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2017]]></dcterms:subject>
    <dcterms:abstract><![CDATA[In situ preparation of polyaniline-ceramic nanocomposites has recently demonstrated that the electrical properties are highly improved with respect to the typical ex situ preparations. In this report, we present for the first time, to the best of our knowledge, the in situ growth of titanium oxide quantum dots in polyaniline host via water vapor flow diffusion as an easily adaptable route to prepare other ceramic-polymer nanocomposites. The main relevance of this method is the possibility to prepare ceramic quantum dots from alkoxide precursors using water vapor flow into any hydrophobic polymer host and to achieve good homogeneity and size-control. In addition, we perform full characterization by means of high-resolution transmission electron microscopy, X-ray powder diffraction, small angle X-ray scattering, thermogravimetric and calorimetric analyses, confocal Raman microscopy and impedance spectroscopy analyses. The presence of the polymer host and interparticle Coulomb repulsive interactions was evaluated as an influence for the formation of ~3&ndash;8 nm equally-sized quantum dots independently of the concentration. The polyaniline polaron population showed an increase for the quantum dots diluted regime and the suppression at the concentrated regime, ascribed to the formation of chemical bonds at the interface, which was confirmed by theoretical simulations. In agreement with the previous observation, the in situ growth of ceramic quantum dots in polyaniline host via water vapor flow diffusion could be very useful as a novel approach to prepare electrode materials for energy conversion and storage applications.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Mombr&uacute;, Dominique</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=a56a5eb113f3814d7ec63df9c488ca48" target="_self"><strong>Romero, Mariano</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=fc7cd71892b1a9968ee19230dafdbd01" target="_self"><strong>Faccio, Ricardo</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=94a8ff70d2730e3c95703f810fd79d7c" target="_self"><strong>Castiglioni, Jorge</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=31ed37f6d0196c1ca18c1b4dfab6de76" target="_self"><strong>Mombr&uacute;, &Aacute;lvaro W.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Solid State Chemistry v. 250, 2017. -- p. 60-67]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2017]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1016/j.jssc.2017.03.016]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2732">
    <dcterms:title><![CDATA[<strong>In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5 nitrofuryl containing thiosemicarbazones.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANTITRIPANOSOMAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIPARASITARIOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[NIFURTIMOX]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2004]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, are described. The designed compounds combine in the same molecule the thiosemicarbazone function, recently described as a potent cruzain-inhibitor moiety, and the recognised 5-nitrofuryl group, an oxidative stress promoter. Some of the derivatives were found to be very active against the cultured (epimastigote) form of the parasite, being 1.5&ndash;1.7-fold more active than the reference compound, Nifurtimox. Free radicals production was detected when the compounds were incubated in presence of mammalian-liver microsomes. The thiosemicarbazones capacity to act as pharmacophore in the cruzain inhibition process was theoretically analysed. Frontier molecular orbital HOMO was found as an adequate descriptor in this process. Acute in vivo toxicity of two of the more active derivatives was evaluated. The results showed that these compounds are among the most potent 5-nitrofuryl derivatives tested against this parasite thus support further in vivo studies of some of these thiosemicarbazones.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Aguirre, Gabriela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Boiani Santurio, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fern&aacute;ndez Silvera, Marcelo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Denicola Creci, Ana Beatriz</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b2795d82d8f9cb610b167b6577f861a5"><strong>Otero Zubiaurre, Ana Luc&iacute;a</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rigol, Carolina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Olea-Azar, Claudio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Faundez, Mario</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Bioorganic and Medicinal Chemistry v. 12, no. 8, 2004. -- p. 4885-4893]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2004]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
<p>&nbsp;</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/j.bmc.2004.07.003]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/4713">
    <dcterms:title><![CDATA[<strong>In vitro activity and mode of action of distamycin analogues against African trypanosomes</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[HIERRO]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRIPANOSOMAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRYPANOSOMA BRUCEI]]></dcterms:subject>
    <dcterms:subject><![CDATA[TIAZOL]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2017]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Distamycin, a natural polyamide containing three heterocycle rings with a polar end, has inspired several groups to prepare synthetic analogues, which proved to have anti-trypanosomal and anti-tumoral activity. We describe the synthesis of bi and tri thiazoles amides that harbor different substitutions at their ends and the evaluation of their anti-Trypanosoma brucei activity. The most active compound 10b showed better biological activity (EC50 310 nM and selectivity index 16) than the control drug nifurtimox (EC50 15 &mu;M and selectivity index 10). Studies on the mode of action show that the parasiticidal activity of 10b originates from disruption of lysosomal homeostasis, which is followed by release of redox active iron, an increase in oxidizing species and collapse of cell membrane integrity. In this respect, our study suggests that non-charged lipophylic distamycins destabilize cell membranes.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Franco, Jaime</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Medeiros, Andrea</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ben&iacute;tez, Diego</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Perelmuter, Karen</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1c6ad9332d8217df75da8d2b87aeb826" target="_self"><strong>Serra, Gloria</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Comini, Marcelo A</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Scarone, Laura</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[European Journal of Medicinal Chemistry v. 126, 2017. -- p. 776-788]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2017]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1016/j.ejmech.2016.12.002]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/7024">
    <dcterms:title><![CDATA[<strong>In vitro alexiteric activity of irregular monoterpenes derived from ortho-menthane against bothrops diporus Cope (Serpentes: Viperidae) venom</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[BACCHARIS TRIMERA]]></dcterms:subject>
    <dcterms:subject><![CDATA[VENENO DE SERPIENTE]]></dcterms:subject>
    <dcterms:subject><![CDATA[CARQUEJOL]]></dcterms:subject>
    <dcterms:subject><![CDATA[CARQUEJA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2025]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Many plant-derived compounds, mostly of mid-to-high molecular weight, exert alexiteric properties. However, some small phenolic molecules, such as 2-hydroxy-4-methoxybenzoic acid, are also known to be alexiteric by their ability to bind to snake venom proteins. This study presents the in vitro alexiteric activity of 2-isopropenyl-3-methylphenol [carquejiphenol, CARP; a minor compound of Baccharis trimera (Less.) DC. essential oil, BtEO] against Bothrops diporus Cope snake venom through the evaluation of proteolysis inhibition, haemolysis and coagulation and alteration of the venom proteins bands followed by SDS-PAGE. Additional CARP derivatives (ortho-menthane monoterpenes), including carquejol and carquejone, as well as BtEO and non-volatile extracts from B. trimera were included to have a broader picture of the alexiteric bioactivity. Notably, carquejone was the more active among all the tested samples. A basic structure-activity comparison with commercial standards revealed that the α,β-unsaturated carbonyl moiety is essential for the bioactivity.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Minteguiaga, Manuel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torres, Ana M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ricciardi Verrastro, Bárbara</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ricciardi, Gabriela A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Catalán, César A. N.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Dellacassa, Eduardo</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Natural Product Research, 2025.--]]></dcterms:source>
    <dcterms:publisher><![CDATA[Taylor &amp; Francis]]></dcterms:publisher>
    <dcterms:date><![CDATA[2025]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[7 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Inglés]]></dcterms:language>
    <dcterms:type><![CDATA[Artículo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1080/14786419.2025.2463694]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2143">
    <dcterms:title><![CDATA[<strong>In vitro and in silico analysis of the Aspergillus nidulans DNA-CreA repressor interactions</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ASPERGILLUS NIDULANS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2014]]></dcterms:subject>
    <dcterms:subject><![CDATA[HONGOS]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The CreA protein mediates carbon catabolite repression in the fungus Aspergillus nidulans. Its DNA-binding domain belongs to the Cys2-His2 class, binding specifically to a 5' SYGGRG 3' nucleotide sequence. EMSA experiments showed that the CreA(G27D) mutation resulted in a 30-fold increase of the Kdiss, and footprinting revealed a altered pattern of protein/DNA contacts. We modeled the CreA and the CreA(G27D) complexes in silico. A 15&thinsp;ns molecular dynamics simulation of the solvated CreA(G27D) and CreA models was carried out using the MOE 2007.09 suite and the Amber99 force field. We have focused our analysis in residues Arg14, Glu16, His17, and Arg20 and Arg44, Asp46, and Arg50, previously, shown to be responsible for the specific contacts of the two Zn fingers. The electrostatic and the total potential energies showed the CreA(G27D) mutation to decrease the affinity of the complex, in agreement with the Kdiss's values. The in silico approach highlighted the role of the inter-finger linker. We identified several differential structural characteristics of the CreA and CreA(G27D)/DNA complexes and observed that the latter resulted in a lower dynamic flexibility of the complex.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="curr&iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8b87e8e50f3fa6cbb61ecc6edf70e6f8" target="_blank"><strong>Esper&oacute;n, Patricia</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Scazzocchio, C.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="curr&iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2e3c62395a54ce79c86b7e4fa4b5c3f9" target="_blank"><strong>Paulino, Margot</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Biomolecular Structure and Dynamics v. 32, no 12, 2014. -- p. 2033-2041]]></dcterms:source>
    <dcterms:publisher><![CDATA[Taylor and Francis]]></dcterms:publisher>
    <dcterms:date><![CDATA[2014]]></dcterms:date>
    <dcterms:rights><![CDATA[<p align="LEFT"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p style="margin-bottom: 0cm;"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
<p><br /><br /></p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1080/07391102.2013.843474]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/1201">
    <dcterms:title><![CDATA[<strong>In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[TRIPANOSOMIASIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[LEISHMANIOSIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIPROTOZOARIOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRYPANOSOMA CRUZI EPIMASTIGOTES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QU&Iacute;MICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2009]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Exploring the influence of different substitution patterns of 2H-benzimidazole 1,3-dioxide derivatives (BzNO) we prepared fifteen new derivatives. Initially the BzNO were tested against Trypanosoma cruzi Tulahuen 2 strain epimastigote form rendering very potent anti-T. cruzi agents. Moreover, the BzNO were able to inhibit the growth of virulent and resistant to Benznidazole strains (CL Brener clone, Colombiana, and Y strains) and to Leishmania braziliensis. Interestingly, BzNO exhibited very high selectivity index and particularly the spiro-BzNO 13 provokes an important diminution of amastigotes in Vero cells. Besides, it was found a diminution of acetate and glycine as excreted metabolites but without increase of parasite glucose uptake indicating that the glycosome is probably not involucrate in the 2H-benzimidazole 1,3- dioxides mechanism of action]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Boiani Santurio, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gerpe, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ar&aacute;n, Vicente J</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torres de Ortiz, Susana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Serna, Elba</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vera de Bilbao, Ninfa</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sanabria, Luis</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Yaluff, Gloria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Nakayama, H&eacute;ctor</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rojas de Arias, Antonieta</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Maya, Juan Diego</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Morillo, J. Antonio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[European Journal of Medicinal Chemistry |g v. 44, no. 3, 2009. -- p.1034-1040]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2009]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingles]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN: 0223-5234]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/4514">
    <dcterms:title><![CDATA[<strong>In vitro and in vivo uptake studies of PAMAM G4.5 dendrimers in breast cancer</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANTITUMORALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[CANCER DE MAMA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ADMINISTRACION DE FARMACOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2016]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Background Breast cancer is the second leading cause of cancer death worldwide. Nanotechnology approaches can overcome the side effects of chemotherapy as well as improve the efficacy of drugs. Dendrimers are nanometric size polymers which are suitable as drug delivery systems. To the best of our knowledge, studies on the application of PAMAM G4.5 (polyamidoamine half generation 4) dendrimers as potential drug delivery systems in breast cancer have not been reported. In this work we developed a PAMAM G4.5 dendrimer containing FITC (fluorescein isothiocyanate) dye to study their uptake by murine breast cancer cells and BALB/c mice breast tumors. Results We performed a reaction between FITC and PAMAM G4.5 dendrimers which were previously derivatized with piperazine (linker molecule), characterized them by 1H NMR (proton nuclear magnetic resonance) spectroscopy and MALDI-TOF (matrix-assisted laser desorption/ionization- time-of-flight) mass spectrometry. The experimental data indicated that 2 FITC molecules could be bound covalently at the PAMAM G4.5 dendrimer surface, with 17 FITC molecules probably occluded in PAMAM dendrimers cavity. PAMAM-FITC dendrimer (PAMAM G4.5-piperazinyl-FITC dendrimer) size distribution was evaluated by DLS (dynamic light scattering) and TEM (transmission electron microscopy). The nanoparticle hydrodynamic size was 96.3 &plusmn; 1.4 nm with a PdI (polydispersion index) of 0.0296 &plusmn; 0.0171, and the size distribution measured by TEM was 44.2 &plusmn; 9.2 nm. PAMAM-FITC dendrimers were neither cytotoxic in 4T1 cells nor hemolytic up to 24 h of incubation. In addition, they were uptaken in vitro by 4T1 cells and in vivo by BALB/c mice breast tumors. PAMAM G4.5-piperazinyl-FITC dendrimer intracellular distribution was observed through histologic analysis of the tumor by laser confocal microscopy.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Oddone, Natalia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lecot, Nicole</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fern&aacute;ndez , Marcelo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=e763cfcf3da319d62989630831835a77" target="_blank"><strong>Rodr&iacute;guez Haralambides, Alejandra</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cabral, Pablo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Benech, Juan Claudio</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Nanobiotechnology v. 14, 2016. -- 12p.-- e45]]></dcterms:source>
    <dcterms:publisher><![CDATA[BioMed Center]]></dcterms:publisher>
    <dcterms:date><![CDATA[2016]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1186/s12951-016-0197-6]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/4825">
    <dcterms:title><![CDATA[<strong>In vitro Anti-snake Venom Activities of Aloysia citriodora Palau :New Possibilities for a Known Aromatic Plant</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ACEITES ESENCIALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[PLANTAS AROMATICAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALOYSIA CITRIODORA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIVENENOSOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2017]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Traditional medicine in Corrientes Province (Argentina) uses herbs preparations in the form of infusions and cataplasms as an alternative medication for the treatment of bites from venomous animals. Aloysia citriodora is widely used in folk medicine to treat different disorders, but only few authors cite this Vervenaceae as antivenom against snake bites. In this work, we studied the effect of essential oils and extracts from aerial parts of A. citriodora against Bothrops diporus venom, yarar&aacute; chica, so as to evaluate the traditional antisnake venom properties suggested for this species. In addition, a seasonal and geographical evaluation of the chemical composition of the essential oil was performed in order to assess its chemical stability. Results showed that A. citriodora possesses in vitro antisnake venom activity and that essential oil components could be considered as a part of its active constituents. These are most likely responsible for the plant&rsquo;s potential therapeutic benefits since they attenuate the proteolytic, coagulant and indirect hemolytic activities of B. diporus venom. Our results support the ethnopharmacological use of this species as antivenom, and backs the need to continue the research in order to identify the components responsible for the antivenom activity evaluated.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>C&aacute;ceres, Marcela I.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ricciardi, Gabriela A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torres, Ana M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ricciardi, Barbara B.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ferrero, Susana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2df81feedac99473a4e536d2623f04c3" target="_blank"><strong>Dellacassa, Eduardo.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Essential Oil Bearing Plants v. 20, no. 1, 2017. -- p. 132-140]]></dcterms:source>
    <dcterms:publisher><![CDATA[Taylor &amp; Francis]]></dcterms:publisher>
    <dcterms:date><![CDATA[2017]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)&nbsp;</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Inglés]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1080/0972060X.2016.1239551]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/5102">
    <dcterms:title><![CDATA[<strong>In Vitro Anti/Pro-oxidant Activities of R. ferruginea Extract and Its Effect on Glioma Cell Viability : Correlation with Phenolic Compound Content and Effects on Membrane Dynamics</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[LIPOSOMAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPUESTOS FENOLICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[GLIOMA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2018]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Rapanea ferruginea antioxidant and antitumoral properties were not explored before in literature. This study aimed to investigate these biological activities for the R. ferruginea leaf extract and correlate them with its phenolic content and influence in biological membrane dynamics. Thus, in this study, anti/pro-oxidative properties of R. ferruginea leaf extract by in vitro DPPH and TBARS assays, with respect to the free radical reducing potential and to its activity regarding membrane free radical-induced peroxidation, respectively. Furthermore, preliminary tests related to the extract effect on in vitro glioma cell viability were also performed. In parallel, the phenolic content was detected by HPLC-DAD and included syringic and trans-cinnamic acids, quercetrin, catechin, quercetin, and gallic acid. In an attempt to correlate the biological activity of R. ferruginea extract and its effect on membrane dynamics, the molecular interaction between the extract and a liposomal model with natural-sourced phospholipids was investigated. Location and changes in vibrational, rotational, and translational lipid motions, as well as in the phase state of liposomes, induced by R. ferruginea extract, were monitored by Fourier-transform infrared spectroscopy, nuclear magnetic resonance, differential scanning calorimetry, and UV-visible spectroscopy. In its free form, the extract showed promising in vitro antioxidant properties. Free-form extract (at 1000&micro; g/mL) exposure reduced glioma cell in vitro viability in 40%, as evidenced by MTT tests. Pro-oxidant behavior was observed when the extract was loaded into liposomes. A 70.8% cell viability reduction was achieved with 500 &micro;g/mL of liposome-loaded extract. The compounds of R. ferruginea extract ordered liposome interface and disorder edits a polar region. Phenolic content, as well as membrane interaction and modulation may have an important role in the oxidative and antitumoral activities of the R. ferruginea leaf extract.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Magalh&atilde;es dos Santos, Desir&eacute;e</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Jardim Rocha, Camila Valesca</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ferreira da Silveira, Elita</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Germani Marinho, Marcelo Augusto</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Osti Silva, Nichole</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>da Silva Ferreira, Ailton</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fernandes de Moura, Neusa</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sagrera Darelli, Gabriel Jorge.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Braganhol, Elizandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Horn, Ana Paula</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rodrigues de Lima, V&acirc;nia</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[The Journal of Membrane Biology v. 251, 2018. --p. 247-261]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2018]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong> ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI:10.1007/s00232-018-0017-z]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2860">
    <dcterms:title><![CDATA[<strong>In vitro antimicrobial activity of different accessions of Solanum commersonii Dun. from Uruguay.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[SOLANUM COMERSONI]]></dcterms:subject>
    <dcterms:subject><![CDATA[CANDIDA ALBICANS]]></dcterms:subject>
    <dcterms:subject><![CDATA[STAPHYLOCOCCUS AUREUS]]></dcterms:subject>
    <dcterms:subject><![CDATA[GLICOALCALOIDES]]></dcterms:subject>
    <dcterms:subject><![CDATA[MICROBIOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2004]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The in vitro antimicrobial activity of extracts from accessions ofSolanum commersonii Dun. collected in the south of Uruguay was investigated against five microorganisms including the pathogenRalstonia solanacearum. A total of 30 extracts corresponding to organic and aqueous extracts were studied. Interestingly, most of the positive results for growth inhibition were againstR. solanacearum. The extracts were also analyzed for the presence of glycoalkaloids and lectins. Six of the ten aqueous extracts showed lectin presence and a wide variation in the type and amounts of glycoalkaloids, was found. Results indicate that there is no clear relationship between the antimicrobial activity against the five microorganisms screened and the presence or amounts of lectins and glycoalkaloids, traditionally regarded as possible antimicrobial metabolites in theSolanum genus, which indicates the presence of as yet unidentified antimicrobial compounds.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=69e1fbd1ead47d6eac7b0e7dfd65494a"><strong>Siri, Mar&iacute;a In&eacute;s</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Villanueva, P</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=3bf812f622bbbd9412704b46f88c34c5"><strong>Pianzzola, Mar&iacute;a Julia</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=729d3d9bb07d7be0ba5e4dc762c01e29"><strong>Franco Fraguas, Laura</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Galv&aacute;n, G</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Acosta, M</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=06ea8350d5f6e14cde5d4fa22f5ff626"><strong>Ferreira Chiesa, Fernando</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Potato Research v. 47, no. 3-4, 2004. -- p. 127-138]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2004]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1007/BF02735979]]></dcterms:identifier>
    <dcterms:coverage><![CDATA[Uruguay]]></dcterms:coverage>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6798">
    <dcterms:title><![CDATA[<strong>In vitro antiviral activity of favipiravir and its 6- and 3-O-substituted derivatives against coronavirus: acetylation leads to improvement of antiviral activity</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ACETILACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[COVID 19]]></dcterms:subject>
    <dcterms:subject><![CDATA[FAVIPIRAVIR]]></dcterms:subject>
    <dcterms:subject><![CDATA[VIROLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2024]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Favipiravir is currently approved for the treatment of the influenza virus and has shown encouraging results in terms of antiviral capacity in clinical studies against severe acute respiratory syndrome coronavirus 2. Favipiravir is a prodrug, where its favipiravir‐ribofuranosyl‐5B‐triphosphate metabolite is capable of blocking RNA replication of the virus. However, the antiviral efficiency of favipiravir is limited by two factors: (i) low accumulation in plasma and rapid excretion/elimination postadministration and (ii) low conversion rate into the active metabolite. To tackle these problems, herein, we have designed new favipiravir analogues focusing on the replacement of the fluorine atom at the 6-position by halogen or hydrogen atoms and 3-O-functionalization with labile groups. The first type of functionalization seeks to increase the antiviral activity because of the better ability of the keto-tautomer as a function of the halogen, and it is hypothesized that the keto-tautomer tends to promote the formation of the ribofuranosyl-5B-triphosphate (RTP) metabolite. Meanwhile, the second type of functionalization seeks to promote lipophilicity and increase accumulation in cells. From the in vitro antiviral activity against two coronavirus models (bovine and human 229E), it was identified that the replacement did not improve the antiviral activity against both the models, which seems to be attributable to the low water solubility of these new 6-functionalized analogues. Meanwhile, with 3-O-functionalization, acetylation provided the most active compounds with higher half‐maximal inhibitory concentration and selectivity than favipiravir, whereas benzylation/methanosulfonation yielded the least active compounds. In summary, acetylation is found to be a convenient functionalization to enhance the antiviral profile of favipiravir.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Elizalde, Valeria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mirazo, Santiago</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Romero, Angel H.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Alvarez, Guzman</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Archiv der Pharmazie v. 357, n&deg;1, 2024]]></dcterms:source>
    <dcterms:publisher><![CDATA[Wiley]]></dcterms:publisher>
    <dcterms:date><![CDATA[2024]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[11 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1002/ardp.202300494]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2436">
    <dcterms:title><![CDATA[<strong>In vitro approach to study the influence of the cardiac output distribution on drug concentration</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CARDIOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[SANGRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[SISTEMA CARDIOVASCULAR]]></dcterms:subject>
    <dcterms:subject><![CDATA[PRODUCTOS FARMACEUTICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Blood flow is not constant during the day, not only due to cardiac output variation but to the variable blood flow fraction supplied to the organs. To what extent these variations could affect the relative drug concentration between two different tissues, is the purpose of this work. In order to study that, a device was designed which took into account different fluid flows towards two flasks. Connections between flasks and pump are shown in text (figure 1). At the bottom of each flask a non-miscible liquid (dichloromethane: CH2Cl2, 100 mL, places 2 and 3) with the circulating fluid (water, 1350 mL, places 1, A, B) was placed. Malachite Green (MG) was introduced as solute into the system (place 1,5 mL, 700 mg/L aqueous solution). The pump output was set at 1080 mL/min, serving more fluid (five times) to flask A than to flask B. Samples were drawn from compartments 1, A and B, and from organic compartments, during experiences taking several hours. MG concentrations were colorimetrically measured at 619 nm. Room temperature was between 15&ndash;25 &deg;C. CH2Cl2 MG concentration ratio ([2]/[3]) was similar to fluid flow ratio (&sigma;/(1-&sigma;)) all over the experience time. Other experiences changing the stop time, room temperature, CH2Cl2 volumes and places, pump output distribution, led us to different evidences that supported a theoretical model. As a conclusion, the most important feature was that whereas MG concentrations in water (1, A, B) were close, in CH2Cl2 these were very different. So, is drug effect prediction reliable by monitoring free drug concentrations in blood? European Journal of Drug Metabolism and Pharmacokinetics European Journal of Drug Metabolism and Pharmacokinetics Look Inside Article Metrics 3 Citations Co-published with Adis Adis Other actions Export citation Register for Journal Updates About This Journal Reprints and Permissions Add to Papers Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Fagiolino, Pietro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Wilson, F.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Samaniego, E.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vazquez, M.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[European Journal of Drug Metabolism and Pharmacokinetics v. 28, no. 2, 2003. -- p. 147-153]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2003]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1007/BF03190504]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6379">
    <dcterms:title><![CDATA[<strong>In Vitro bioaccessibility of bioactive compounds from citrus pomaces and orange pomace biscuits&nbsp;</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[AMILASAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[INFLAMACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIOXIDANTES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIOACCESIBILIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[CITRICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[DIABETES]]></dcterms:subject>
    <dcterms:subject><![CDATA[GLUCOSIDASA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANALISIS SENSORIAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2021]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<p>The present investigation aimed to provide novel information on the chemical composition and in vitro bioaccessibility of bioactive compounds from raw citrus pomaces (mandarin varieties Clemenule and Ortanique and orange varieties Navel and Valencia). The effects of the baking process on their bioaccessibility was also assessed. Samples of pomaces and biscuits containing them as an ingredient were digested, mimicking the human enzymatic oral gastrointestinal digestion process, and the composition of the digests were analyzed. UHPLC-MS/MS results of the citrus pomaces flavonoid<br />composition showed nobiletin, hesperidin/neohesperidin, tangeretin, heptamethoxyflavone, tetramethylscutellarein, and naringin/narirutin. The analysis of the digests indicated the bioaccessibility of compounds possessing antioxidant [6.6&ndash;11.0 mg GAE/g digest, 65.5&ndash;97.1 mol Trolox Equivalents<br />(TE)/g digest, and 135.5&ndash;214.8 mol TE/g digest for total phenol content (TPC), ABTS, and ORAC-FL methods, respectively; significant reduction (p &lt; 0.05) in Reactive Oxygen Species (ROS) formation under tert-butyl hydroperoxide (1 mM)-induced conditions in IEC-6 and CCD-18Co cells when pre-treated with concentrations 5&ndash;25 g/mL of the digests], anti-inflammatory [significant reduction (p &lt; 0.05) in nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages], and antidiabetic (IC50 3.97&ndash;11.42 mg/mL and 58.04&ndash;105.68 mg/mL for -glucosidase and -amylase inhibition capacities) properties in the citrus pomaces under study. In addition, orange pomace biscuits with the nutrition claims &ldquo;no-added sugars&rdquo; and &ldquo;source of fiber&rdquo;, as well as those with good sensory quality (6.9&ndash;6.7, scale 1&ndash;9) and potential health promoting properties, were<br />obtained. In conclusion, the results supported the feasibility of citrus pomace as a natural sustainable source of health-promoting compounds such as flavonoids. Unfractionated orange pomace may be employed as a functional food ingredient for reducing the risk of pathophysiological processes linked to oxidative stress, inflammation, and carbohydrate metabolism, such as diabetes, among others.</p>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?48a71d2e5134808569068d2724790a8aea8b2933a5fec257ee3e4e79c698c53217947faea852f59905ef92c97b0830d7d801d00a336d676bae44ed023b6adffa" target="_blank"><strong>Fern&aacute;ndez Fern&aacute;ndez, Adriana Maite</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?5a728c53379ba11edafc6029548ce29d65b0e495e64982b067a2707fc9d44e90fa33fc21f214f2d552656809bf896fdbcfece552c850bab35f4d18fc3812ebd9" target="_blank"><strong>Dellacassa, Eduardo</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Nardin, Tiziana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Larcher, Roberto</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>G&aacute;mbaro, Adriana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?7c64fd0475a2077f15b2edfba26c864ffb58e74137469e728a10a1e9f597797565a168ad79a66a0e079ca1f99d19153126e8d3094144e8ab95c1a3e8ff5e8111" target="_blank"><strong>Medrano Fernandez, Alejandra</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>del Castillo, Mar&iacute;a Dolores</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Molecules&nbsp;v. 26. n&deg; 12, 2021. --pp. 1-18. -- e3480]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2021]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derechode autor</strong><span>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong><span>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span></span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[<span id="docs-internal-guid-6dc1c3f1-7fff-844d-e8e2-b26a30d02e9d"><span>10.3390/molecules26123480&nbsp; </span></span>]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6627">
    <dcterms:title><![CDATA[<strong>In vitro bioaccessibility of copper, iron, and zinc from common meat substitutes, influence of exogenously added garlic/onion and contribution to the diet</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CARNE VACUNA]]></dcterms:subject>
    <dcterms:subject><![CDATA[CARNE DE POLLO]]></dcterms:subject>
    <dcterms:subject><![CDATA[SUSTITUTOS DE LA CARNE]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIOACCESIBILIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2023]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Copper (Cu), iron (Fe) and zinc (Zn) bioaccessibility was studied in beef, chicken, chickpeas, lentils, quinoa, soybeans, and tuna fish using an in vitro assay. Samples were cooked as usually consumed locally. Analytical determinations were performed by atomic absorption spectrometry. The samples that presented the highest bioaccessible fraction (BF) were soybeans (~87 %) (Cu), chickpeas (~78 %) (Fe), and quinoa (~92 %) (Zn), respectively. Zinc was the mineral that presented the highest BF value of all, being above 66 % in all food samples. The effect of garlic and onion on the BF was also evaluated, being the highest effects observed for quinoa with a percent increase of 26.9 % (Fe) promoted by garlic and 19.7 % (Zn) promoted by onion. The contribution of Cu, Fe and Zn to the recommended dietary allowance (RDA) for adults over 19 years was esti mated, considering a 200 g portion. Soybeans and lentils contributed between 56.7 % and 78.9 % (men and women) to Cu RDA, chickpeas, lentils, and soybeans contributed an average of 34.6 % (men) and 15.4 % (women) to Fe RDA, while beef contributed an average of 65.5 % (men) and 90.1 % (women) to Zn RDA. This information shows that beef is a major source of Zn to the diet.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?c0cbafe8dc697fcc5404f7374858d5aed14ebcbf12487622fa045fdb51a24ac0e3c78d1e4e764d5cddfa16d69f6f8d47e39d8117166e5e06853fe499f6fad284" target="_blank"><strong>Iaquinta, Fiorella</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?bd38543d99b5350c7bf3b234ee5d9861" target="_blank"><strong>Rodr&iacute;guez, Nataly</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?5c1ca4d55a5933a1752b3fc23d7cad09c4e5df59004aa474d3d272c7b6b5d79efe1957de15b2f0c75050b8d88b94dc89f36f3a8703836670d171bb4291eb6134" target="_blank"><strong>Machado, Ignacio</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Food Composition and Analysis v.115, 2023. -- e104910]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2023]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[7 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.jfca.2022.104910]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6282">
    <dcterms:title><![CDATA[<strong>In vitro bioaccessibility of Cu and Zn in cooked beef cuts</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ZINC]]></dcterms:subject>
    <dcterms:subject><![CDATA[COBRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIOACCESIBILIDAD]]></dcterms:subject>
    <dcterms:subject><![CDATA[CARNE VACUNA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2021]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<p>Cu and Zn bioaccessibility was studied in two different beef cuts (rib plate and top sirloin), through the development of an in vitro assay. Samples were cooked at two degrees of doneness (medium and well-done) as usually consumed locally, to establish the contribution to the recommended daily allowance (RDA). Simulated gastrointestinal conditions were optimized and trueness of the method was evaluated by performing mass balances. Analytical determinations were performed by atomic absorption spectrometry and microwave-induced plasma optical emission spectrometry. No significant differences were found between the studied cuts nor between the degrees of doneness evaluated. Mean bioaccessible fraction (BF) of Zn was 83%, for both cuts and both degrees of doneness. In the case of Cu, rib plate presented a mean BF of 20%, while for top sirloin was of 38%. However, these differences found between cuts and degrees of doneness were not statistically significant. The contribution of Cu and Zn to the RDA for adults over 19 years was estimated, as an example, considering a 200 g portion. Results showed that the RDA of Zn would be completely covered, while the contribution to the RDA of Cu would be up to 33%.</p>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Iaquinta, Fiorella.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=61479bcedba0147d3c3d319c58b33c3b8097d0e921a472a96c977f72410c865c0f760872b9315b74ede8b43e4be18142c73316e553e66830ee9d5a4c2cfdd139&amp;formato=pdf&amp;convocatoria=21"><strong>Pist&oacute;n, Mariela.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=5c1ca4d55a5933a1752b3fc23d7cad09c4e5df59004aa474d3d272c7b6b5d79efe1957de15b2f0c75050b8d88b94dc89f36f3a8703836670d171bb4291eb6134&amp;formato=pdf&amp;convocatoria=21"><strong>Machado, Ignacio.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[LWT, v. 150, 2021. -- p. 156&ndash;164. -- e112027]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2021]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho&nbsp;de autor</strong><span> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<span id="docs-internal-guid-1ef6baa1-7fff-ec52-9caf-02da89aa9376"><strong>ADVERTENCIA:</strong><span> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span></span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[<a class="doi" title="Persistent link using digital object identifier" href="https://doi.org/10.1016/j.lwt.2021.112027" rel="noreferrer noopener" target="_blank">https://doi.org/10.1016/j.lwt.2021.112027</a>]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/4759">
    <dcterms:title><![CDATA[<strong>In vitro bioaccessibility study of As, Cd, Cu, Fe, Ni, Pb and Zn from raw edible artichoke heads (Cynara cardunculus L. subsp. Cardunculus)</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ALCACHOFAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS FUNCIONALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[SEGURIDAD ALIMENTICIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2017]]></dcterms:subject>
    <dcterms:abstract><![CDATA[A study to evaluate nutritional properties of raw edible globe artichoke heads as a source of minerals was performed. To perform a properly approach on this issue the determination of total concentration of minerals is not sufficient, it is necessary to know about the bioaccessibility of each element. Due to the widespread pollution problems, food is not only a source of essential minerals but also contributes to the intake of toxic elements by human beings. To asses both, nutritional properties and food safety of raw edible globe artichoke heads, the concentrations of total arsenic (As), cadmium (Cd), copper (Cu), iron (Fe), nickel (Ni), lead (Pb) and zinc (Zn) were determined in 10 samples from Uruguayan markets. Analytical determinations were performed using flame and electrothermal atomic absorption spectrometry. In all samples, the decreasing sequence of the mean total concentrations was: Fe &gt; Zn &gt; Cu &gt; Ni with values ranges between 35.8 and 57.8 mg kg&minus; 1 (Fe), 27.7 to 42.2 mg kg&minus; 1 (Zn), 5.4 to 7.5 mg kg&minus; 1 (Cu) and 1.9 to 3.4 mg kg&minus; 1 (Ni). In vitro bioaccessibility assays showed that the decreasing sequence of bioaccessibility for these elements was Cu &gt; Zn &gt; Ni &gt; Fe with bioaccessibility factors percentages ranged between 71.3 and 82.3% (Cu), 51.2&ndash;64.2% (Zn), 41.3&ndash;54.7% (Ni) and 39.5&ndash;49.7% (Fe). Total concentrations of As, Cd and Pb were far below the maximum limits established by regional regulations in all samples, presenting negligible bioaccessibility. Results demonstrate that raw edible artichoke heads are a good source mainly of Cu, Zn with an interesting contribution to the daily intake of these essential elements. This novel information provides a starting point for more complex and in-depth evaluations from the nutritional point of view, including the establishment of a recommended daily dietary intake for a non-traditional food.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Machado, Ignacio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=0a105db2a5a7c020d6e14e25180d1b21" target="_self"><strong>Cesio, Mar&iacute;a Veronica</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=617ff0430e37557fbf5f99096500417c" target="_self"><strong>Pist&oacute;n, Mariela</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Microchemical Journal v. 133, 2017. -- p. 663-668]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2017]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong> ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1016/j.microc.2017.03.005]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2443">
    <dcterms:title><![CDATA[<strong>In vitro steroid metabolism during final oocyte maturation in white croaker Micropogonias furnieri</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[OVOCITOS-MADURACI&Oacute;N]]></dcterms:subject>
    <dcterms:subject><![CDATA[MICROPOGONIAS FURNIERI]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The main steroids produced by three stages ovarian fragments (post-vitellogenic PV, oocytes in GV migration phase Mtg and mature oocytes M) of white croaker were compared. In Mtg and M stages 17,20&beta;-dihydroxy-4- pregnen-3-one (17,20&beta;P), 17,21-dihydroxy-4-pregnene-3,20-dione (17,21P) and 17,20&beta;,21-trihydroxy-4-pregnen- 3-one (20&beta;-S) were synthesised. The specific synthesis of 20&beta;S in Mtg oocytes suggests a MIS role for this steroid]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Garc&iacute;a-Alonso, J</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Nappa, A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Somoza, G. M</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong><a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=9b0f413dec677697679ef0eb972502e2" target="_blank">Rey, A.</a><br /></strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vizziano, D</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Fish Physiology and Biochemistry v. 28, no. 1-4, 2003. -- p. 337-338]]></dcterms:source>
    <dcterms:publisher><![CDATA[Kluwer Academic Publishers]]></dcterms:publisher>
    <dcterms:date><![CDATA[2003]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1023/B:FISH.0000030577.79235.2e]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/3021">
    <dcterms:title><![CDATA[<strong>In vitro taurocholate-induced segmentation and clustering of Mesocestoides vogae (syn. corti) tetrathyridia (Cestoda)- inhibition by cestocidal drugs</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANTIPARASITARIOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2001]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Mesocestoides vogae (syn. M. corti) tetrathyridia were cultured in the presence of sodium taurocholate, for the purpose of exploring the suitability of this organism for the in vitro assay of cestocidal drugs. Parasite clustering and segmentation were observed as taurocholate-dependent effects in biphasic and monophasic media, respectively. Interestingly, representative members of two major classes of known cestocidal agents (namely, albendazole and praziquantel) blocked these effects. Furthermore, it was possible to determine a specific concentration of the drugs that inhibited clustering and segmentation (minimum inhibitory concentration). In contrast, no inhibition was obtained in the presence of anthelmintics without cestocidal activity. These observations open the way for further studies focused at understanding how the activity of the drugs is involved in the suppression of the taurocholate-induced effects.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1adf3c6818ae9c0ff60309b22359778f"><strong>Salda&ntilde;a, Jenny</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Marin, M</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=9664a257b8e611abc245a6f6ef902c2a"><strong>Fern&aacute;ndez, Cecilia</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=ae579f47d769d2ed742a6a34064041f6"><strong>Dom&iacute;nguez, Laura</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Parasitology Research v. 87, , 2001]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2001]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1007/PL00008579]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2240">
    <dcterms:title><![CDATA[<strong>In vivo anti-chagas vinyl thio-, vinysulfinyl-, and vinylsulfonylbenzofuroxan derivatives</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[AGENTES ANTICHAGAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2007]]></dcterms:subject>
    <dcterms:abstract><![CDATA[New benzofuroxans were developed and studied as antiproliferative Trypanosoma cruzi agents. Compounds displayed remarkable in Vitro activities against different strains, Tulahuen 2, CL Brener and Y. Its unspecific cytotoxicity was evaluated using human macrophages being not toxic at a concentration at least 8 times, and until 250 times, that of its T. cruzi IC50. Some biochemical pathways were studied, namely parasite respiration, cysteinyl active site enzymes and reaction with glutathione, as target for the mechanism of action. Not only T. cruzi respiration but also Cruzipain or trypanothione reductase were not affected, however the most active derivatives, the vinylsulfinyl- and vinylsulfonyl-containing benzofuroxans, react with glutathione in a redox pathway. Furthermore, the compounds showed good in ViVo activities when they were studied in an acute murine model of Chagas&rsquo; disease. The compounds were able to reduce the parasite loads of animals with fully established T. cruzi infections.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=01ded1b48a793797e49a8cb9b67aecea"><strong>Porcal, Williams</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Hernandez, Paola</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Boiani Santurio, Mariana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Aguirre, Gabriela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Boiani Santurio, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Chidichimo, Agustina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cazzulo, Juan J</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Campillo, Nuria E</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Paez, Juan A</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Castro, Ana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Krauth-Siegel, R. Luise</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Davies, Carolina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Basombr&iacute;o, Miguel Angel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Medicinal Chemistry v.50, no.24, 2007. --p.6004-6015]]></dcterms:source>
    <dcterms:publisher><![CDATA[American Chemical Society]]></dcterms:publisher>
    <dcterms:date><![CDATA[2007]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1021/jm070604e]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2193">
    <dcterms:title><![CDATA[<strong>In Vivo Anti-Trypanosoma cruzi Activity of Hydro-Ethanolic Extract and Isolated Active Principles from Aristeguietia glutinosa and Mechanism of Action Studies</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[TRIPANOSOMIASIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTITRIPANOSOMAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ARISTIGUIETIA GLUTINOSA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2014]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The currently available treatments for Chagas disease show limited therapeutic potential and are associated with serious side effects. Attempting to find alternative drugs isolated from Nature as agents against Trypanosoma cruzi has been our goal. Recently, we have demonstrated the in vitro anti-T. cruzi activities of two secondary metabolites isolated from the hydro-ethanolic extract of the aerial parts of Aristeguietia glutinosa (Lam.), (family Asteraceae). These active principles displayed poor hemolytic activity, low toxicity against murine macrophages, and absence of mutagenicity. Herein, proof of concept in vivo studies of the whole hydro-ethanolic extract of the aerial parts of Aristeguietia glutinosa and of the most active component isolated from the hydro-ethanolic extract, i.e., (+)-15-hydroxy-7-labden-17-al, was done in a murine acute model of Chagas disease. Both treatments caused a decrease in the animals' parasitemia. Metabolomic mechanism of action studies were done by 1H-NMR, both on the extract and on the active compounds, examining the effects of the metabolites both on membrane sterol biosynthesis and mitochondrial dehydrogenases, whereby we found that one of the metabolites inhibited the activity of the parasite mitochondrial dehydrogenases and the other inhibited the biosynthesis of parasite membrane sterols. The results are interesting in the context of popular use of plants for the treatment of Chagas disease.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Varela, Javier</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Serna, Elva</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torres, Susana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Yaluff, Gloria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vera de Bilbao, Ninfa I.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mi&ntilde;o, Patricio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Chiriboga, Ximena</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Molecules v. 19, 2014. -- p. 8488-8502]]></dcterms:source>
    <dcterms:publisher><![CDATA[Multidisciplinary Digital Publishing Institute (MDPI)]]></dcterms:publisher>
    <dcterms:date><![CDATA[2014]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.3390/molecules19068488]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6221">
    <dcterms:title><![CDATA[<strong>In Vivo High Plasticity of Multi-Drug Resistant ST258 Klebsiella pneumoniae</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[KLEBSIELLA PNEUMONIAE
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:subject>
    <dcterms:subject><![CDATA[BACTERIAS RESISTENTES
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:subject>
    <dcterms:subject><![CDATA[2020
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Carbapenemase production in Enterobacterales clinical isolates is a global threat. Multi-drug resistant Klebsiella pneumoniae harboring carbapenemases are a major concern among the hospital settings in Latin America. Aim: The aim of this study was to analyze the genetic relatedness between three isolates of K. pneumoniae recovered from one patient in the same bacteriological round on the same day, which exhibited different susceptibility profiles to carbapenems (CP) and to colistin (Col). Isolates&rsquo; profiles were as follows (susceptible- S/resistant-R): CPS/ColR, CPR/ColR, and CPR/ColS. Pulse-field gel electrophoresis, multilocus sequence typing, and whole genome sequencing were performed. Conjugation assays were carried out and PCR determination in transconjugants (Tcs) was made for: blaCTX-M-groups, blaNDM, blaKPC, blaTEM, qnr alleles, aac(6&cent;)Ib-cr, ermB, and plasmid incompatibility groups (Inc). Results: All isolates belonged to the same clone, to ST258 and harbored blaCTX-M-14, blaCTX-M-15, qnrA1, qnrB1, aac(6&cent;)Ib-cr, and wzi154 (capsule-locus KL107). One isolate had additional wzi gene, wzi109 (capsulelocus KL36). In CPR isolates, the pattern was explained for blaNDM-1 or blaNDM-1/blaKPC-2 presence, and in ColR for IS5-like element insertion in mgrB at different positions. Co-mobilization of blaNDM-1/qnrA1 was associated to a different plasmid Inc (A/C-FII) in both blaNDM-1 donors. Mobilization of blaCTX-M-14 was related to IncI1 in one donor. Conclusion: These findings highlight the potential plasticity of ST258 K. pneumoniae clone. To the best of our knowledge, this is the first description of blaNDM-1/blaKPC-2-producing K. pneumoniae ST258 in Latin America.
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Garcia Fulgueiras, Virginia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Magallanes, Carmen</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Reyes, Victoria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cayota, Camila</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Galiana, Antonio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vieytes, Mariela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vignoli, Rafael</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>M&aacute;rquez, Carolina</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Microbial Drug Resistance 2020. -- p. 1-5.--e310
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:source>
    <dcterms:publisher><![CDATA[Mary Ann Liebert
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:publisher>
    <dcterms:date><![CDATA[2020
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong> (Por favor lea este aviso antes de abrir los documentos u objetos)<strong> La legislaci&oacute;n uruguaya protege el derecho de autor </strong>sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:rights>
    <dcterms:format><![CDATA[Pdf
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1089/mdr.2020.0310
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/1536">
    <dcterms:title><![CDATA[<strong>In vivo studies of 5- arylethenybenzofuroxans in acute murine models of Chagas&acute; disease</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ENFERMEDAD DE CHAGAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[2008]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:abstract><![CDATA[5-Arylethenylbenzofuroxan derivatives with high in vitro anti-Trypanosoma cruzi activity were studied in vivo using acute murine models of Chagas&rsquo; disease. The selected compounds, as pure isomeric forms, 1, 2, 3 and 4, or as equimolecular mixture of geometric isomers, 1:2, 3:4, 5:6 were studied against different T. cruzi strains. Consequently, Tulahuen 2 strain, Colombiana strain (resistant to Nifurtimox and Benznidazole), and two different wild strains, one isolated from the wild reservoir Didelphis marsupialis and another one from Uruguayan patients, were selected. No relevant signs of in vivo toxicity were observed with the benzofuroxans orally administered. Compound 1 and the mixture of isomers 1:2 were the best for treating infection against the four studied strains.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Boiani Santurio, Luc&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Davies, Carolina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Arredondo, Carolina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=01ded1b48a793797e49a8cb9b67aecea" target="_blank"><strong>Porcal, Williams</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Merlino, Alicia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gerpe, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Boiani Santurio, Mariana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pacheco, Jos&eacute; Pedro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Basombr&iacute;o, Miguel Angel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[European Journal of Medicinal Chemistry v. 43, no. 10, 2008. -- p. 2229-2237]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2008]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho de autor</strong> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong> ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/j.ejmech.2007.12.016]]></dcterms:identifier>
</rdf:Description></rdf:RDF>
