<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2035">
    <dcterms:title><![CDATA[<strong>New copper based complexes with quinoxaline N1, N4-dioxide derivatives, potential antitumoral agents</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[COMPLEJOS DE COBRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[AGENTES ANTITUMORALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[2008]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Taking into account our previous studies on cytotoxic metal compounds, new copper complexes with 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives as ligands were synthesized and characterized by different spectroscopic methods. The hypoxic selective cytotoxicity towards V79 cells and the superoxide dismutase-like activity of the complexes were determined and related to physicochemical properties of the compounds. In particular, the copper(II) complex with 3-amino-6-chloro-7-fluoroquinoxaline-2-carbonitrile N1,N4-dioxide showed cytotoxic selectivity in hypoxia being the most lipophilic compound of the series. On the contrary, the complex with 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide was cytotoxic but not selective and that with 3-amino-7-chloro-6-methoxy-quinoxaline-2-carbonitrile N1,N4-dioxide was not cytotoxic towards V79 cells neither in oxia nor in hypoxia in the assayed conditions. The &sigma;m Hammett substituent electronic descriptor was related to the effect in hypoxic conditions and the SOD-like activity was correlated to the effect in normoxia.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Urquiola, Carolina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cabrera, Mauricio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lavaggi, Mar&igrave;a Laura</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lopez de Cerain, Adela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Monge, Antonio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa-Filho, Antonio J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042" target="_blank"><strong>Torre, Mar&iacute;a H.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Inorganic Biochemistry v. 102, no. 1, 2008. -- p.119-126]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2008]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/j.jinorgbio.2007.07.028]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6619">
    <dcterms:title><![CDATA[<strong>New Copper(II)-L-Dipeptide-Bathophenanthroline complexes as potential anticancer agents&mdash;synthesis, characterization and cytotoxicity studies&mdash;and comparative DNA-Binding study of related phen complexes</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[COMPLEJOS DE COBRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[PEPTIDOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ADN]]></dcterms:subject>
    <dcterms:subject><![CDATA[ACTIVIDAD CITOTOXICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[FENANTROLINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2023]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Searching for new copper compounds which may be useful as antitumor drugs, a series of new [Cu(L-dipeptide)(batho)] (batho:4,7-diphenyl-1,10-phenanthroline, L-dipeptide: Gly-Val, Gly Phe, Ala-Gly, Ala-Ala, Ala-Phe, Phe-Ala, Phe-Val and Phe-Phe) complexes were synthesized and characterized. To interpret the experimental IR spectra, [Cu(ala-gly)(batho)] was modelled in the gas phase using DFT at the B3LYP/LANL2DZ level of theory and the calculated vibrational frequencies were analyzed. Solid-state characterization is in agreement with pentacoordinate complexes of the general formula [Cu(L-dipeptide)(batho)]&middot;x solvent, similar to other [Cu(L-dipeptide)(diimine)] complexes. In solution, the major species are heteroleptic, as in the solid state. The mode of binding to the DNA was evaluated by different techniques, to understand the role of the diimine and the dipeptide. To this end, studies were also performed with complexes [CuCl2 (diimine)], [Cu(L dipeptide)(diimine)] and free diimines, with phenanthroline, neocuproine and 3,4,7,8-tetramethyl phenanthroline. The cytotoxicity of the complexes was determined on human cancer cell lines MDA-MB-231, MCF-7 (breast, the first triple negative), and A549 (lung epithelial) and non-tumor cell lines MRC-5 (lung) and MCF-10A (breast). [Cu(L-dipeptide)(batho)] complexes are highly cytotoxic as compared to cisplatin and [Cu(L-dipeptide)(phenanthroline)] complexes, being potential candidates to study their in vivo activity in the treatments of aggressive tumors for which there is no curative pharmacological treatment.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?6ff98e50c61daf2fd24006b2cb221c82" target="_blank"><strong>Fern&aacute;ndez, Carlos Y.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?e635b6babb330f7d853c44bebf28147f45249ebe02a83f148a2cc7d1d4cfc6eb7c052c905498e0db71ce84c545c5bc262c0c1fa15dd485e385d82024819cf422" target="_blank"><strong>Alvarez, Natalia</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rocha, Analu</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ellena, Javier</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa Filho, Antonio J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Batista, Alzir A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?a41bd5cdd282cee0c5c8be3585cd7593514fcf7fb722e1194e086a5aa98159780502b217d616fd5bb450c02a6152253b7a8957278f35e3a01aabdd446a54f376" target="_blank"><strong>Facchin, Gianella</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Molecules v.28, n&deg;2, 2023]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2023]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[14 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3390/molecules28020896]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/4347">
    <dcterms:title><![CDATA[<strong>New derivates of 2-diphenylmethoxyethylamine with vasodilator and spasmolytic activity</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[MEDICINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[ESTUDIOS CLINICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[1977]]></dcterms:subject>
    <dcterms:creator><![CDATA[<strong>Iba&ntilde;ez, A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Roig, M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ruiz, J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Queralt, J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>De Catellarnan, C.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Badia, A.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[European Journal of Medicinal Chemistry - Chimica Therapeutica v. 12, n&ordm;. 5, 1977. -- p. 459-462]]></dcterms:source>
    <dcterms:publisher><![CDATA[Soci&eacute;t&eacute; de chimie th&eacute;rapeutique (France)]]></dcterms:publisher>
    <dcterms:date><![CDATA[1977]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN: 0223-5234]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2540">
    <dcterms:title><![CDATA[<strong>New directions towards safer and effective vaccines for Alzheimer&acute;s disease.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ENFERMEDAD DE ALZHEIMER]]></dcterms:subject>
    <dcterms:subject><![CDATA[VACUNAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[INMUNOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2005]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The first experimental vaccine against Alzheimer's disease caused encephalitis in some patients, which led to termination of the clinical trial and dealt a serious blow to this therapeutic approach. With second-generation vaccines that are likely to circumvent this side effect, this type of therapy remains promising, although more extensive animal studies are likely to be required before approval of other clinical trials. Another potential side effect, microhemorrhages within the brain vasculature, has been observed in mouse models following passive immunization, but has not been assessed in reports of active vaccination. Together, these serious adverse reactions emphasize the need to test potential Alzheimer's immunotherapy in large cohorts of primate models prior to, or at least concurrently with, human trials, as no effective therapy exists for the disease.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Go&ntilde;i, Fernando</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sigurdsson, E. M</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Current Opinion in Molecular Therapeutics v. 7, no. 1, 2005. -- p. 17-23]]></dcterms:source>
    <dcterms:publisher><![CDATA[Thomson]]></dcterms:publisher>
    <dcterms:available><![CDATA[2005]]></dcterms:available>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
<p>&nbsp;</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN: 1464-8431]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/3267">
    <dcterms:title><![CDATA[<strong>New effects in the electrochemistry of carbon dioxide on platinum by the solid-state reactions occurring via a two-phase or single-phase solid solution pathway.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ELECTROQUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[DIOXIDO DE CRBONO]]></dcterms:subject>
    <dcterms:subject><![CDATA[PLATINO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[1999]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The electroformation and electrooxidation of carbon dioxide adsorbates were studied on polycrystalline and preferentially oriented platinum surfaces by the application of medium frequency potential perturbations in saturated carbon dioxide aqueous sulphuric acid solutions. Preferentially oriented platinum surfaces were obtained by the application of fast symmetric square wave potential programmes to polycrystalline electrodes based on well-known methodology. Two new electrochemical characteristics for the electrochemistry of carbon dioxide were observed after the application of the medium frequency routines, that is, an extended adsorption potential domain for the formation of carbon dioxide adsorbates, and novel voltammetric features for the two anodic stripping peaks. These effects upon carbon dioxide electrochemistry are dependent on the morphology of the platinum electrode surface and adsorption potentials.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Mendez, Eduardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Martins, M.E</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Zinola S&aacute;nchez, Carlos Fernando</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of electroanalytical chemistry v. 477, no. 1, 1999. -- p. 41]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[1999]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/S0022-0728(99)00387-3]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2283">
    <dcterms:title><![CDATA[<strong>New fac-tricarbonyl rhenium(I) semicarbazone complexes: synthesis, characterization, and biological evaluation</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[RENIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRIPANOSOMIASIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[SEMICARBAZONAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2014]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Expanding our previous work on salicylaldehyde semicarbazone metal complexes as prospective anti-trypanosomal agents, five new fac-ReI(CO)3-containing complexes with ligands of this semicarbazone series were synthesized and characterized. An atypical coordination mode of these potentially tridentate ligands through only the carbonylic oxygen and the azomethine nitrogen (the so-called N,O fashion) was demonstrated by IR spectroscopy and supported by theoretical calculations. Three of the compounds showed moderate in vitro anti-Trypanosoma cruzi activity and increased activity with respect to the corresponding free ligands. The brominated ligands, 5-bromo-2-hydroxybenzaldehyde semicarbazone (L2) and 5-bromo-2-hydroxy-3-methoxybenzaldehyde semicarbazone (L5), led to the most active rhenium(I) complexes. These compounds are among the few reported examples of rhenium complexes bearing in vitro activity against T. cruzi.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Machado, Ignacio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fern&aacute;ndez, Soledad</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Becco Sierra, Lorena Lourdes</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Garat Bizzozero, Beatriz Maria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong><a title="curr&iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=fd97168d9e8b7d3f82474969b5b78453" target="_blank">Gancheff, Jorge S.</a></strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="curr&iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=9b0f413dec677697679ef0eb972502e2" target="_blank"><strong>Rey, Ana</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="curr&iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Coordination Chemistry v. 67, no. 10, 2014. -- p. 1835-1850]]></dcterms:source>
    <dcterms:publisher><![CDATA[Taylor &amp; Francis Group]]></dcterms:publisher>
    <dcterms:date><![CDATA[2014]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI:10.1080/00958972.2014.926008]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/89">
    <dcterms:title><![CDATA[<strong>New family of thiocyanate-bridged Re(IV)-SCN-M(II) (M = Ni, Co, Fe, and Mn) heterobimetallic compounds : Synthesis, crystal structure, and magnetic properties</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[METALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[QUIMICA INORGANICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TIOCIANATO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2012]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<p>The heterobimetallic complexes of formula [(Me2phen)2M(&mu;-NCS)- Re(NCS)5]&middot;CH3CN [Me2phen = 2,9-dimethyl-1,10-phenanthroline and M = Ni (1), Co (2), Fe (3), and Mn (4)] have been prepared, and their crystal structures have been determined by X-ray diffraction on single crystals. Compounds 1&minus;4 crystallize in the monoclinic C2/c space group, and their structure consists of neutral [(Me2phen)2M(&mu;-NCS)Re(NCS)5] heterodinuclear units with a Re-SCN-M bridge. Each Re(IV) ion in this series is six-coordinated with one sulfur and five nitrogen atoms from six thiocyanate groups building a somewhat distorted octahedral environment, whereas the M(II) metal ions are five-coordinated with four nitrogen atoms from two bidentate Me2phen molecules and a nitrogen atom from the bridging thiocyanate describing distorted trigonal bipyramidal surroundings. The values of the Re&middot;&middot;&middot;M separation through the thiocyanate bridge in 1&minus;4 vary in the range 5.903(1)&minus; 6.117(3) &Aring;. The magnetic properties of 1&minus;4 as well as those of the parent mononuclear Re(IV) compounds (NBu4)2[Re(NCS)6] (A1) (NBu4 + = tetra-n-butylammonium cation) and [Zn(NO3)- (Me2phen)2]2[Re(NCS)5(SCN)] (A2) were investigated in the temperature range 1.9&minus;300 K. Weak antiferromagnetic interactions between the Re(IV) and M(II) ions across the bridging thiocyanate were found in 1&minus;4 [J = &minus;4.3 (1), &minus;2.4 (2), &minus;1.8 (3), and &minus;1.2 cm&minus;1 (4), the Hamiltonian being defined as Ĥ = &minus;JŜRe&middot;ŜM]. The magnetic behavior of A2 is that of a magnetically diluted Re(IV) complex with a large and positive value of the zero-field splitting for the ground level (DRe = +37.0 cm&minus;1). In the case of A1, although its magnetic behavior is similar to that of A2 in the high-temperature range (DRe being +19.0 cm&minus;1), it exhibits a weak ferromagnetism below 3.0 K with a canting angle of 1.3&deg;.</p>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b1b5b2e2cf087c725fd16c86fe84f724" target="_blank"><strong>Gonz&aacute;lez, Ricardo</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Acosta, Alvaro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=ee0fd5f657739f812de617121a701ab6" target="_blank"><strong>Chiozzone, Raul</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6f16399c452f7b13f8a01a148cb38e12" target="_blank"><strong>Kremer, Carlos</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Armentano, D.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>De Munno, G.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Julve, M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lloret, F.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Faus, J.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Inorganic Chemistry  51, no. 10, 2012. -- p. 5737-5747]]></dcterms:source>
    <dcterms:publisher><![CDATA[American Chemical Society]]></dcterms:publisher>
    <dcterms:date><![CDATA[2012]]></dcterms:date>
    <dcterms:rights><![CDATA[<p align="LEFT"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p style="margin-bottom: 0cm;"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
<p><br /><br /></p>
<p style="margin-bottom: 0cm;">&nbsp;</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[dx.doi.org/10.1021/ic300200k]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/28">
    <dcterms:title><![CDATA[<strong>New functional fibre in milk puddings : effect on sensory properties and consumers`acceptability</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANALISIS SENSORIAL]]></dcterms:subject>
    <dcterms:subject><![CDATA[LECHE]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QU&Iacute;MICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2009]]></dcterms:subject>
    <dcterms:subject><![CDATA[FIBRAS]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<p>The effect of the addition of a new functional fibre (high-amylose maize starch, HAMS, as a source of resistant starch), recently available in the market, on <strong>sensory characteristics</strong> and consumers' acceptability of <strong>milk puddings</strong> was studied. Milk puddings containing modified waxy maize starch and &kappa;-carrageenan were produced with different HAMS concentrations (0, 1, 2, 3 and 4%). Higher HAMS concentration caused changes in the sensory characteristics of milk puddings. Particularly, sensory attributes such as some roughness, rough afterfeel and floury taste appeared. Besides, the addition of HAMS caused an increase in manual and oral thickness and a decrease in creaminess, melting, and sweetness. A HAMS enrichment level of 1.4% in this product was estimated as the maximum concentration that does not significantly modify consumers' overall acceptability. Using survival analysis the proportion of consumers who would buy milk desserts containing 1.4 % HAMS was estimated as 71%.<strong> Consumers</strong> more interested in consuming functional foods enriched with fibre were more tolerant to the sensory changes caused by the addition of HAMS to the <strong>milk puddings</strong>.</p>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=358965ab1701bacbb43e4f5a24a8e876"><strong>Ares, Gast&oacute;n</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Baixauli, Raquel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sanz, Teresa</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Varela, Paula</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Salvador, Ana</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[LWT-Food Science and Technology v.42, no. 3, 2009. -- p.710-716]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2009]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><em><strong>Informaci&oacute;n sobre Derechos de Autor</strong> </em></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><em><strong>La legislaci&oacute;n uruguaya</strong></em> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><em><strong> ADVERTENCIA</strong></em> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI 10.1016/j.lwt.2008.10.004]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/5251">
    <dcterms:title><![CDATA[<strong>New Functional Ingredients From Agroindustrial By-Products for the Development of Healthy Foods</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ALIMENTOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS SALUDABLES]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS FUNCIONALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[ALIMENTOS FUNCIONALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIOXIDANTES]]></dcterms:subject>
    <dcterms:subject><![CDATA[FIBRSS IETETICAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2018]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The present study aimed to obtain novel information regarding the pathways of a polyphenol-rich coffee silverskin extract (CSE) for inhibiting the formation of advanced glycation products (AGE). Chlorogenic acid (CGA) is the main phenol present in coffee beans. The contribution of CGA to the antiglycoxidative properties of CSE was also evaluated by analysis of CGA standard. The CGA (90%) and CSE (49%) significantly inhibited (p &lt; 0.001) the formation of fluorescent AGE in a protein&ndash;methylglyoxal (MGO) model system (37 &deg;C for 96 h). The lack of MGO-derivative AGE in the presence of CGA and CSE was verified using liquid chromatography&ndash;tandem mass spectrometry techniques, which evidenced the almost complete absence of arginine adducts after 24 h of reaction. The inhibitory effect of polyphenols present in CSE may be associated to its carbonyl trapping capacity as well as to its ability to react with side-chains of protein amino residues blocking the reaction sites. In conclusion, aqueous CSE can be considered a natural source of various inhibitors of in vitro formation of AGE acting by different pathways. Inhibitors of advanced glycation end products from coffee bean roasting by-product]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Cozzano Ferreira, Sonia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fern&aacute;ndez Fern&aacute;ndez, Adriana Maite.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>del Castillo Bilbao, Mar&iacute;a Dolores</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Medrano Fernandez, Alejandra</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Encyclopedia of Food Security and Sustainability / Pasquale Ferranti Elliot Berry Anderson Jock, edsr, 2018 p. 1-9]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2018]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Auto</strong>r</p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1016/B978-0-08-100596-5.22140-9]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2088">
    <dcterms:title><![CDATA[<strong>New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[RESONANCIA DE SPIN ELECTRONICO]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRIPANOSOMIASIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPUESTOS HETEROCICLICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[CINETICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[EXPERIMENTOS CON ANIMALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2010]]></dcterms:subject>
    <dcterms:abstract><![CDATA[their free radical-trapping properties. The physicochemical characterization by electron paramagnetic resonance (EPR) demonstrated its capability to trap and stabilize oxygen-, carbon-, sulfur-, and nitrogen- centered free radicals. The 4-furoxanyl nitrone 3 (FxBN), a(Z)-(3-methylfuroxan-4-yl)-N-tert-butylnitrone, showed appropriate solubility in aqueous solution and taking into account that this physicochemical property is very important for biological applications, we studied it deeply in terms of its trapping and kinetic behaviors. For this, kinetic studies of the hydroxyl adduct decay gave rate constants kST of 1.22  1010 dm3 mol1 s1 and half-live up to 7200 s at physiological pH, without any artifactual signals. The ability of FxBN to directly traps and stabilizes superoxide free radical, with a half-life of 1620 s at physiological pH, was also demonstrated. Besides, FxBN-hydroxyl and -superoxide adducts exhibited distinct and characteristic EPR spectral patterns. Finally, we confirmed the ability of FxBN to act as spin trap in a specific biological system, that is, in the free radical production of experimental anti-trypanosomatid drugs using Trypanosoma cruzi microsomes as biological system. Moreover, previous observations of low FxBN toxicity transform it in a good candidate for in vivo spin trapping]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Barriga, Germ&aacute;n</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Olea-Azar, Claudio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Norambuena, Ester</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Castro, Ana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=01ded1b48a793797e49a8cb9b67aecea"><strong>Porcal, Williams</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gerpe, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Bioorganic and Medicinal Chemistry v. 18, no. 2, 2010. -- p. 795-802]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2010]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/j.bmc.2009.11.053]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/5344">
    <dcterms:title><![CDATA[<strong>New heterobimetallic ferrocenyl derivatives : Evaluation of their potential as prospective agents against trypanosomatid parasites and Mycobacterium tuberculosis</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[LEISHMANIASIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TUBERCULOSIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTITRIPANOSOMAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2018]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Searching for prospective agents against infectious diseases, four new ferrocenyl derivatives, [M(L)(dppf)4](PF6), with M = Pd(II) or Pt(II), dppf = 1,1'-bis(dipheny1phosphino) ferrocene and HL = tropolone (HTrop) or hinokitiol (HHino), were synthesized and characterized. Complexes and ligands were evaluated against the bloodstream form of T. brucei, L. infantum amastigotes, M. tuberculosis (MTB) sensitive strain and MTB clinical isolates. Complexes showed a significant increase of the anti-T. brucei activity with respect to the free ligands (&gt;28- and &gt;46-fold for Trop and 6- and 22-fold for Hino coordinated to Pt-dppf and Pd-dppf, respectively), yielding IC50 values &lt; 5 &mu;M. The complexes proved to be more potent than the antitrypanosomal drug Nifurtimox. The new ferrocenyl derivatives were more selective towards the parasite than the free ligands. The Pt compounds were less toxic on J774 murine macrophages (mammalian cell model), than the Pd ones, showing selectivity index values (SI = IC50 murine macrophage/IC50T. brucei) up to 23. Generation of the {M-dppf} compounds lead to a slightly positive impact on the anti-leishmanial potency. Although the ferrocenyl derivatives were more active on sensitive MTB than the free ligands (MIC90 = 9.88-14.73 &mu;M), they showed low selectivity towards the pathogen. Related to the mechanism of action, the antiparasitic effect cannot be ascribed to an interference of the compounds with the thiol-redox homeostasis of the pathogen. Fluorescence measurements pointed at DNA as a probable target of the new compounds. [Pt(Trop)(dppf)](PF6) and [Pt(Hino)(dppf)](PF6) could be considered prospective anti-T. brucei agents that deserve further research.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Rivas, Feriannys</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Medeiros, Andrea</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rodr&iacute;guez Arce, Esteban</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Comini, Marcelo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ribeiro, Camila M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pavan, Fernando R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_self"><strong>Gambino, Dinorah.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Inorganic Biochemistry v. 187, 2018. -- p. 73-84]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2018]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1016/j.jinorgbio.2018.07.013]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/5925">
    <dcterms:title><![CDATA[<strong>New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ENFERMEDAD DE CHAGAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRIPANOSOMIASIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTITRIPANOSOMAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMIC]]></dcterms:subject>
    <dcterms:subject><![CDATA[2019]]></dcterms:subject>
    <dcterms:abstract><![CDATA[In the search for a more effective chemotherapy for the treatment of Chagas&rsquo; disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic compounds may be a promising strategy. In this work, eight new heterobimetallic compounds are described including four 5-nitrofuryl containing thiosemicarbazones as bioactive ligands (HL1&ndash;HL4) and dppf = 1,1&prime;-bis(diphenylphosphino) ferrocene as an organometallic co-ligand. Complexes of the formula [MII(L)(dppf)](PF6) with M = Pd or Pt were synthesized and fully characterized in the solid state and in solution, including the determination of the molecular structure of four of them by single crystal X-ray diffraction methods. Most compounds showed activity in the low micromolar or submicromolar range against both parasites, with the platinum compounds being more active than the palladium analogues. Activity was significantly increased by generation of the M-dppf compounds (3&ndash;24 fold increase with respect to free ligands HL for T. cruzi and up to 99 fold increase with respect to HL for T. brucei). The inclusion of the organometallic co-ligand also led to lower toxicity in mammalian cells and higher selectivity towards both parasites when compared to the free HL compounds. The complexes interact with DNA and affect the redox metabolism of the parasites. Furthermore, the most active and selective compound of the new series showed no in vivo toxicity in zebrafish embryos.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Rodr&iacute;guez Arce, Esteban</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Putzu, Eugenia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lapier, Michel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Maya, Juan Diego</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Olea-Azar, Claudio.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Echeverr&iacute;a, Gustavo A</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Piro, Oscar E.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Medeiros, Andrea</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sardi, Florencia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Comini, Marcelo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Risi, Gast&oacute;n.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8b2cacb0aafc512133624fa7b9bf174c" target="_self"><strong>Salinas, Gustavo.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Correia, Isabel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa Pessoa, Jo&atilde;o</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b2795d82d8f9cb610b167b6577f861a5" target="_self"><strong>Otero Zubiaurre, Ana Luc&iacute;a</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_self"><strong>Gambino, Dinorah.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Dalton Transactions v. 48, no. 22, 2019.--p. 7644-7658]]></dcterms:source>
    <dcterms:publisher><![CDATA[Royal Society of Chemistry]]></dcterms:publisher>
    <dcterms:date><![CDATA[2019]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1039/C9DT01317B]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/5530">
    <dcterms:title><![CDATA[<strong>New heteroleptic oxidovanadium(V) complexes: synthesis, characterization and biological evaluation as potential agents against Trypanosoma cruzi</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[VANADIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[OXIDOVANADIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[SINTESIS QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRIPANOSOMA CRUZI]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2018]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Searching for prospective vanadium-based agents against Trypanosoma cruzi, the parasite causing Chagas disease, four new [VVO(8HQ&ndash;H)(L&ndash;2H)] compounds, where 8HQ is 8-hydroxyquinoline and L are tridentate salicylaldehyde semicarbazone derivatives L1&ndash;L4, were synthesized and characterized in the solid state and in solution. The compounds were evaluated on T. cruzi epimastigotes (CL Brener) as well as on VERO cells, as mammalian cell model. Compounds showed activity against T. cruzi (IC50 6.2&ndash;10.5 &mu;M) of the same order than Nifurtimox and 8HQ, and a four- to sevenfold activity increase with respect to the free semicarbazones. For comparison, [VVO2(L&ndash;H)] series was prepared and the new [VVO2(L3&ndash;H)] was fully characterized. They showed negligible activity and low selectivity towards the parasite. The inclusion of 8HQ as ligand in [VVO(8HQ&ndash;H)(L&ndash;2H)] compounds led to good activities and increased selectivity towards the parasite with respect to 8HQ. 51V NMR experiments, performed to get insight into the nature of the active species, suggested partial decomposition of the compounds in solution to [VVO2(L&ndash;H)] and 8HQ. Depending on the dose, the compounds act as trypanocide or trypanostatic. A high uptake of vanadium in the parasites (58.51&ndash;88.9% depending on dose) and a preferential accumulation in the soluble protein fraction of the parasite was determined. Treated parasites do not seem to show a late apoptotic/necrotic phenotype suggesting a different cell death mechanism. In vivo toxicity study on zebrafish model showed no toxicity up to a 25 &micro;M concentration of [VVO(8HQ&ndash;H)(L1&ndash;2H)]. These compounds could be considered prospective anti-T. cruzi agents that deserve further research.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Scalese, Gonzalo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=5c1ca4d55a5933a1752b3fc23d7cad09c4e5df59004aa474d3d272c7b6b5d79efe1957de15b2f0c75050b8d88b94dc89f36f3a8703836670d171bb4291eb6134&amp;formato=pdf&amp;convocatoria=21" target="_self"><strong>Machado, Ignacio</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Risi, Gast&oacute;n</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=972518dae04cc6f1d53fd01909f7c2f4952184c3eedf364530afd35a4c507484cce1f86606ac8d829a37e89b7a9f837b6b0632e94efbaf9ba6abf23efe48f1dc&amp;formato=pdf&amp;convocatoria=21" target="_self"><strong>Salinas, Gustavo.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez-D&iacute;az, Leticia.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=6bb5dcce3e2559101357796ca4a2b2d4c9ba6b3a978a0bd4c5dab0107081b73e1ff46dcf49a7de2b571ff7980c4a01789f09f1d7eac1b879a8553641f940b9a5&amp;formato=pdf&amp;convocatoria=21" target="_self"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Biological Inorganic Chemistry v. 23, no. 8, 2018. -- p. 1265-1281]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2018]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1007/s00775-018-1613-1]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/5943">
    <dcterms:title><![CDATA[<strong>New hexanuclear FeIII clusters with the gem-diol hydrated form of di(2-pyridyl)ketone and carboxylato ligands :&nbsp; Crystal structures and magnetic properties</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[HIERRO]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS DE HIERRO]]></dcterms:subject>
    <dcterms:subject><![CDATA[CARBOXILATOS DE HIERRO]]></dcterms:subject>
    <dcterms:subject><![CDATA[ESTRUCTURA CRISTALINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[PROPIEDADES MAGNETICAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2019]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The hexanuclear compounds [Fe6O2Cl2{(py)2CO2}2(pyOH)2(pyCOO)2(ButCOO)6] (1) and [Fe6O2{(py)2CO2}2(pyCOO)4(ButCOO)6] (2) were obtained by condensation of the trinuclear &mu;3-oxo-centered iron(III) pivalate [Fe3O(ButCOO)6(H2O)3]+ in the presence of di(2-pyridyl)ketone [(py)2CO] in MeCN at ambient temperature. Both complexes contain an analogous core which can be described as two {Fe3O}7+ units joined by gem-diolato (py)2CO22&minus; bridges. Variable-temperature magnetic susceptibility measurements in polycrystalline samples of 1 and 2 reveal strong antiferromagnetic couplings between the iron(III) ions leading to S = 0 ground states.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=2d464bf82e7bcaa15f4b0fbb018032c3001b5ddbb2f3240974290c1101a83a48fdf510e499125c718077733be2e225e06e5bc041529e5912a19205af86801bf0&amp;formato=pdf&amp;convocatoria=21" target="_self"><strong>Arizaga, Livia.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Canon-Mancisidor, Walter</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&amp;rct=j&amp;q=&amp;esrc=s&amp;source=web&amp;cd=1&amp;ved=2ahUKEwiZ-IW13b_mAhW2HrkGHc3xC5wQFjAAegQIAxAH&amp;url=https%3A%2F%2Fexportcvuy.anii.org.uy%2FCvEstatico%2F%3FurlId%3D527cc3038d59833a4c909767bd7f6a3379095d3a0cdc61b11c5885fee523d22afd20bae2ffe6db18c286b4d96984040347c98393790883f271799b54992d9ed0%26formato%3Dpdf%26convocatoria%3D21&amp;usg=AOvVaw3AobPa3tMci0Na0a8ZOfMc" target="_self"><strong>Gancheff, Jorge S.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Burrow, Robert A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Armentano, Donatella</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lloret, Francesc</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&amp;rct=j&amp;q=&amp;esrc=s&amp;source=web&amp;cd=1&amp;cad=rja&amp;uact=8&amp;ved=2ahUKEwic5JOE37_mAhUpD7kGHZ2MCFYQFjAAegQIBBAH&amp;url=https%3A%2F%2Fexportcvuy.anii.org.uy%2FCvEstatico%2F%3FurlId%3D441a03bd8b19a2050aec9a8e68a67aab53e2c04a9ff331e972a69b567b7ffde10472a7d926a2e9038b1940d8e9272a7de07b765740f899b7d19482d36bb42e8a%26formato%3Dpdf%26convocatoria%3D21&amp;usg=AOvVaw1lvZDX6E39nfcna886BIqT" target="_self"><strong>Gonz&aacute;lez, Ricardo.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&amp;rct=j&amp;q=&amp;esrc=s&amp;source=web&amp;cd=1&amp;cad=rja&amp;uact=8&amp;ved=2ahUKEwiA1dyZ4b_mAhUoILkGHbfJBZsQFjAAegQIBxAH&amp;url=https%3A%2F%2Fexportcvuy.anii.org.uy%2Fpdf%2F%3F9e450ba14cecd9ab4f3eb3afee24db93c31091b76bdf313eaf4bb6f48e1aab267b159257e1da3edcf0943d49db8b33f104e170e20dcc8350cdee43a625f33f4e&amp;usg=AOvVaw2011uKHQ_YWNSlDG5L6UcB" target="_self"><strong>Kremer, Carlos</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&amp;rct=j&amp;q=&amp;esrc=s&amp;source=web&amp;cd=2&amp;ved=2ahUKEwirq5vY2b_mAhVpG7kGHRxyBREQFjABegQIBBAH&amp;url=https%3A%2F%2Fexportcvuy.anii.org.uy%2FCvEstatico%2F%3FurlId%3Dfdc403cc2b5146f119b01b540242116f1f09385415a6b12eebb82d2c05b42428fc10f0c6bf466344fd2279f7bffabe5c80586019535e4bc933f888249364399e%26formato%3Dpdf%26convocatoria%3D21&amp;usg=AOvVaw0a5_TSzwu3Xendud2IVpH6" target="_self"><strong>Chiozzone, Ra&uacute;l</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Polyhedron v. 174, 2019. --10p.--e114165]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2019]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho de autor</strong> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Artículo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1016/j.poly.2019.114165]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6532">
    <dcterms:title><![CDATA[<strong>New insights into the biophysical behavior of an old molecule: eperimental and theoretical studies of the interaction between 1,10-Phenanthroline and model phospholipid membranes</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[BIOFISICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[VESICULAS LIPIDICAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[MOLECULAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[FENANTROLINA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[1,10-Phenanthroline, phen, is a molecule with a wide variety of chemical and biological activities, being interesting from a pharmacological standpoint. Its metal complexes have been extensively studied during the last century. Considering the vast applications of phen and its metallic complexes for the development of potential metallodrugs, it becomes of utmost importance to study the molecule&rsquo;s interaction with diferent molecular targets. So far, in-depth analyses of phen and metal&ndash;phen complexes&rsquo; interaction with DNA are abundant. Nevertheless, little has been reported on the interaction of this molecule with the frst molecular &ldquo;target&rdquo; that it fnds in the cell, the lipid membrane. Here, we present the characterization of the interaction of the phen molecule with model membranes of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1,2-dipalmitoyl-sn-glycero-3-phospho-(1&prime;-rac-glycerol) (sodium salt) (DPPG) using a combination of diferential scan ning calorimetry and molecular dynamics simulations. Our results indicate that phen difuses into the membranes, being stabilized around the middle of the hydrocarbon chains in DPPC, while in DPPG, it is placed near the center of the bilayer.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?e635b6babb330f7d853c44bebf28147f45249ebe02a83f148a2cc7d1d4cfc6eb7c052c905498e0db71ce84c545c5bc262c0c1fa15dd485e385d82024819cf422" target="_blank"><strong>Alvarez, Natalia&nbsp;</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Freddi, Priscilla&nbsp;</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Castellani, Stephanie&nbsp;</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?5ad3267f4b4cb5190a6d9a3f5877923f528b6603e8a436c2005a31c5f35cd644629532a16ae958823cff6464fe03287baebd3b8724cc14f8d05da74957fe496d" target="_blank"><strong>Veiga, Nicol&aacute;s&nbsp;</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?a41bd5cdd282cee0c5c8be3585cd7593514fcf7fb722e1194e086a5aa98159780502b217d616fd5bb450c02a6152253b7a8957278f35e3a01aabdd446a54f376" target="_blank"><strong>Facchin, Gianella&nbsp;</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa Filho, Antonio J.&nbsp;</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Brazilian Journal of Physicsv. 52, 2022. -- e111]]></dcterms:source>
    <dcterms:publisher><![CDATA[Sociedade Brasileira de F&iacute;sica]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><span><strong>Informaci&oacute;n sobre Derechos de Autor</strong></span></p>
<p><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong><span>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<p><strong>ADVERTENCIA:</strong><span>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span></p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1007/s13538-022-01114-7]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6762">
    <dcterms:title><![CDATA[<strong>New insights into the chemical composition of Baccharis palustris Heering (Asteraceae) essential oil</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[BACCHARIS PALUSTRIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ACEITES ESENCIALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[POLIACETILENOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2023]]></dcterms:subject>
    <dcterms:abstract><![CDATA[B. palustris Heering (Asteraceae), has been previously characterized as having an unusual essential oil composition with C9-/C10-polyacetylenes as main components, and mono- and sesqui terpenes/terpenoids at minor or trace levels. In this work, new insights into the chemical composition of this oil are presented: 1. TLC profiles using different visualization reagents for their characterization, 2. chemical analyses combining HRGC/qMS, HRGC/HRMS-TOF and HRGCxHRGC/HRMS-TOF, and 3. radical scavenging activity assay using the DPPH methodology were performed. The best TLC visualization conditions for the polyacetylenic components of the oil were obtaining using UV&lambda;= 365 nm and vanillin/H3PO4, while the original application of NaDi (1-naphtol + N,N-dimethyl-p-phenylendiamine) demonstrated to be the best option to visualize the lachnophyllum acid methyl esters fraction. Gas chromatography/mass spectrometry protocols allowed the detection of 63 components in B. palustris oil: 39 of them were identified, 6 tentatively assigned without LRI information, and 18 could not be identified. Most of the identified components were mono- and sesquiterpenes and their derivatives. Ten of them are informed for the first time in B. palustris oil [&alpha;-pinene epoxide, rosefuran, epi-cubebol, cubebol, germacrene D-4-ol, junenol, epi-&alpha;- cadinol, epi-&alpha;-muurolol, germacra-4(15),5,10(14)-trien-1-&beta;-ol and oplopanone]. C9-/C10-polyacetylenes (baccharisdyine/lachnophyllum acid derivatives) were confirmed as the main components of the oil, while other polyacetylenes were tentatively identified and their possible structures are discussed. The deconvolution analyses on HRGCxHRGC/HRMS-TOF allowed the identification of a lachnophyllum lactone isomer (undefined stereochemistry), co-eluting with the (cis)-lachnophyllum acid methyl ester peak. Finally, B. palustris oil was found to be an inactive DPPH radical scavenger.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Minteguiaga, Manuel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Catal&aacute;n, C&eacute;sar Atilio Nazareno</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mercado, Mar&iacute;a In&eacute;s</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Torres, Ana Mar&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ricciardi, Gabriela Ana Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rodr&iacute;guez Rego, Cecilia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Salgar Rangel, William</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Dellacassa, Eduardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Stashenko, Elena</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Brazilian Archives of Biology and Technology v. 66, 2023]]></dcterms:source>
    <dcterms:publisher><![CDATA[Instituto Tecnol&oacute;gico de Paran&aacute;]]></dcterms:publisher>
    <dcterms:date><![CDATA[2023]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[17 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1590/1678-4324-ssbfar-2023230097]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/3621">
    <dcterms:title><![CDATA[<strong>New investigations on copper(II) sebacate : a potentially useful drug for copper supplementation.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[COBRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[FARMACOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS DE COBRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[1994]]></dcterms:subject>
    <dcterms:creator><![CDATA[<strong> Bar&aacute;n, Enrique J</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Etcheverry, S.B</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042"><strong>Torre, Mar&iacute;a H</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=37cace18c8d1da50d33d6bd4f8f1a607"><strong>Kremer, Eduardo</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Acta Farmac&eacute;utica Bonaerense v. 13, no. 2, 1994. -- p. 85-90]]></dcterms:source>
    <dcterms:date><![CDATA[Colegio de Farmac&eacute;uticos de la Provincia de Buenos Aires]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN: 0326-2383]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/4744">
    <dcterms:title><![CDATA[<strong>New isoniazid complexes, promising agents against mycobacterium tuberculosis /</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[COMPLEJOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[QUIMICA INORGANICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[TUBERCULOSIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2013]]></dcterms:subject>
    <dcterms:abstract><![CDATA[La tuberculosis (TB) es una enfermedad p&uacute;blica que produce varios millones de muertes anualmente en todo el mundo. Debido a esta cr&iacute;tica situaci&oacute;n y a la aparici&oacute;n de cepas resistentes a los f&aacute;rmacos usuales, la investigaci&oacute;n de nuevas mol&eacute;culas para el tratamiento de la TB se ha vuelto una prioridad. En este trabajo se reporta la s&iacute;ntesis y caracterizaci&oacute;n por an&aacute;lisis elemental, termogravimetr&iacute;a, medidas conductim&eacute;tricas y espectroscop&iacute;as UV-Vis, IR y EPR de los complejos [Cu(INH)(H2O)]SO4 &sdot;2H2O (Cu-INH) y [CoCl(INH)2(H2O)]Cl&sdot;2.5H2O (Co-INH) con isoniacida (INH). Por otra parte, se determin&oacute; la actividad anti-Mycobacterium tuberculosis (CIMCu-INH = 0.78 &micro;g/mL y CIMCo-INH = 0.19 &micro;g/mL) y la citotoxicidad de los complejos (IC50 = 48.8 and 625 &micro;g/mL respectivamente para los complejos de cobre y cobalto) y se calcul&oacute; el &iacute;ndice de selectividad (62.5 para Cu-INH y 3205 para Co-INH). Estos resultados indican que estos complejos son buenos candidates para continuar estudios futuros.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Poggi, M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Barroso, R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa-Filho, A. J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>De Barros, H. B.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pavan, F.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Leite, C. Q.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042" target="_blank"><strong>Torre, Mar&iacute;a H.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Mexican Chemical Society v. 57, no. 3, 2013. -- p. 198-204]]></dcterms:source>
    <dcterms:publisher><![CDATA[Scielo]]></dcterms:publisher>
    <dcterms:date><![CDATA[2013]]></dcterms:date>
    <dcterms:rights><![CDATA[<p style="margin-bottom: 0cm;"><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /><br />(Por favor lea este aviso antes de abrir los documentos u objetos)<br /><br /><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /><br />(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /><br /><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN 1870-249X]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2001">
    <dcterms:title><![CDATA[<strong>New Limonene-Hybrid Derivatives with Anti-T. cruzi Activity</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANTIFUNGICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ENFERMEDADES PARASITARIAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRYPANOSOMA CRUZI]]></dcterms:subject>
    <dcterms:subject><![CDATA[LIMONENO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2010]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycleframeworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5- nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Alvarez, G.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gerpe, Alejandra</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ben&iacute;tez, D.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Garibotto, F.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Zacchino, S.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Graebin, C.S.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gomes da Rosa, R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Eifler-Lima, V. L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gonz&aacute;lez, Mercedes</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto, Hugo</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Letters in Drug Design and Discovery v. 7, no. 6, 2010. -- p. 452-460]]></dcterms:source>
    <dcterms:publisher><![CDATA[Bentham Science Publishers]]></dcterms:publisher>
    <dcterms:date><![CDATA[2010]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN 1570-1808]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6164">
    <dcterms:title><![CDATA[<strong>New mechanistic insights into the reversible aldol reaction catalysed by</strong><br /><strong>Rhamnulose-1-phosphate aldolase from Escherichia coli</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ESCHERICHIA COLI
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    <dcterms:subject><![CDATA[ANALISIS COMPUTACIONAL
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    <dcterms:subject><![CDATA[CATALISIS
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    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA
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    <dcterms:subject><![CDATA[2020
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    <dcterms:abstract><![CDATA[<p>&nbsp;</p>
<p>Biocatalysts have emerged as promising tools, with aldolases being among the most employed. Unfortunately, the features of their active sites that modulate the mechanistic details have been poorly assessed. Here, the electronic and structural factors associated with the substrates binding and catalytic mechanism of rhamnulose-<br />1-phosphate aldolase (RhuA) from E. coli are computationally analysed. The results allowed us to furnish a holistic view of the RhuA&rsquo;s entire turnover cycle. The active site bears three pockets that anchor different moieties of the substrates: L-rhamnulose-1-phosphate (R1P), dihydroxyacetone phosphate (DHAP) and (S)-lactaldehyde (LLA). The results predict a 5-step catalytic mechanism, being the CeC bond breaking (Ea =24.2 kcal mol&minus;1) and the DHAP deprotonation (Ea =22.0 kcal mol&minus;1) the rate-determining steps for the retro- and aldolic<br />reactions, respectively. The residues E117, E171&prime;, G31 and N29, and the Zn2+ cofactor, play a major role in stabilizing the correct substrates&rsquo; orientation, securing the stereocontrol at C4. Our findings suggest the presence of two acid/base catalytic residues, E117 and E171&prime;, the latter of which being also involved in assisting the CeC<br />bond formation through a concerted protonation of the transition state.</p>
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    <dcterms:creator><![CDATA[<strong>Rigual, Arqu&iacute;mides J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cantero, Jorge</strong>
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    <dcterms:creator><![CDATA[<strong>Risso, Mariela</strong>
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    <dcterms:creator><![CDATA[<strong>Rodr&iacute;guez, Paula</strong>
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    <dcterms:creator><![CDATA[<strong>Rodr&iacute;guez, Sonia</strong>
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    <dcterms:creator><![CDATA[<strong>Paulino, Margot</strong>
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    <dcterms:creator><![CDATA[<strong>Gamenara, Daniela</strong>
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    <dcterms:creator><![CDATA[<strong>Veiga, Nicol&aacute;s</strong>
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    <dcterms:source><![CDATA[Molecular Catalysis v. 495, 2020. -- p. 1-10.--e 111131
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    <dcterms:publisher><![CDATA[Elsevier
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    <dcterms:date><![CDATA[2020
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    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong> (Por favor lea este aviso antes de abrir los documentos u objetos)<strong> La legislaci&oacute;n uruguaya protege el derecho de autor </strong>sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
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    <dcterms:format><![CDATA[Pdf
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    <dcterms:language><![CDATA[Ingl&eacute;s
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    <dcterms:type><![CDATA[Art&iacute;culo
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    <dcterms:identifier><![CDATA[https://doi.org/10.1016/j.mcat.2020.111131
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</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/3441">
    <dcterms:title><![CDATA[<strong>New metabolites from toluene dioxygenase dihydroxilation of oxygenated biphenyls.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[BIOTRANSFORMACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[TOLUENO DIOXIGENASA]]></dcterms:subject>
    <dcterms:subject><![CDATA[METABOLITOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIFENILO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[1997]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Direct microbial oxidation of 2-methoxybiphenyl and 2,3-dimethoxybiphenyl by E. coli JM109 (pDTG601) furnished enantiomerically pure 3-(2-methoxyphenyl)-(1S,2R)-3,5-cyclohexadiene-1,2-diol (2) and 3-(2,3-dimethoxyphenyl)-(1S,2R)-3,5-cyclohexadiene-1,2-diol (3) respectively as the only reaction products. Biphenyl and its mono- and dimethoxy derivatives were subjected to biooxidation with whole cells of E. coli JM109 (pDTG 601). The corresponding diol metabolites were isolated and their absolute stereochemistry determined.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=300838f98061f526032e39f0b9df862d"><strong>Gonz&aacute;lez, David</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=0b6d7b4c1f21766e03e6c9354d672f8d"><strong>Schapiro, Valeria</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=502f70a0642a910f5abf0e0d5c853b61"><strong>Seoane, Gustavo</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong> Hudlicky, T</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Tetrahedron Asymmetry v. 8, no. 7, 1997. -- p. 975-977]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[1997]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/S0957-4166(97)00059-1]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2284">
    <dcterms:title><![CDATA[<strong>New metal complexes of NNO tridentate ligands: Effect of metal center and co-ligand on biological activity</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[ANTINEOPLASICOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS ]]></dcterms:subject>
    <dcterms:subject><![CDATA[METALES]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIOLOGIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2014]]></dcterms:subject>
    <dcterms:abstract><![CDATA[In the search for new agents against Trypanosoma cruzi and cancer the effect of the nature of the metal center and of the presence of a polypiridyl coligand on the antitrypanosomal and antitumoral activities of selected N,N,O ligands [2-(benzothiazol-2-yl-hydrazonomethyl phenol (HL1) and 2-(benzothiazol-2-yl-hydrazonomethyl)-6-methoxyphenol (HL2)] is explored. The new complexes [VVO2(L1)], [VVO2(L2)], [VIVO(L1-H)(phen))] and [GaIII(L2)2](NO3) were synthesized and characterized by using different techniques. The stability of the vanadium complexes in solution was investigated by EPR and 51V NMR spectroscopies and that of the gallium compound by UV&ndash;Vis spectroscopy, 1H NMR and conductivity measurements. While the vanadium complexes show high stability in DMSO, the gallium complex shows very good stability in DMSO and moderate stability in aqueous &ndash; DMSO medium. <br /><br />The cytotoxicity on human tumor cell lines (ovarian A2780, breast MCF7 and prostate PC3 cell lines) that show different sensitivity to cisplatin was evaluated. All the compounds evidenced antiproliferative activity in the micromolar range. The highest cytotoxic activity, in molar units, is shown by [GaIII(L2)2](NO3) (IC50: 1.7 &mu;M) and [VIVO(L1-H)(phen)] (IC50: 2.7 &mu;M) against the ovarian cancer cells. With the exception of [VVO2(L1)], the cytotoxic activity of the ligands and complexes is similar to that of cisplatin in A2780 cells and surpass cisplatin in the other tumor cells. Regarding the activity on T. cruzi, [VIVO(L1-H)(phen)] showed a 10-fold decrease of IC50 with respect to HL1 and an IC50 value (10.7 &mu;M) in the same order of that of the antitrypanosomal drug Nifurtimox (IC50: 6.0 &mu;M). HL2 showed significant growth inhibitory effect on the parasite (IC50: 23.5 &mu;M) and its coordination to Ga(III) lead to a 2-fold increase in activity in molar units (IC50: 14.2 &mu;M). In order to explain the high inhibitory activity of [VIVO(L1-H)(phen)] against the parasite and the tumor cells, the interaction of this compound with plasmid DNA was preliminarily evaluated by AFM. The corresponding images suggest that DNA may be considered as a potential target.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Machado, I.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fern&aacute;ndez, M.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Becco, L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Garat Bizzozero, Beatriz Maria</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Brissos, R. F.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Zabarska, M</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Gamez, P.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Marques, F.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Correia, I.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Costa Pessoa, J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="curr&iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Inorganica Chimica Acta v. 420, 2014. -- p. 39-46]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2014]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/j.ica.2013.10.022]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6597">
    <dcterms:title><![CDATA[<strong>New multifunctional Ru(II) organometallic compounds show activity against Trypanosoma brucei and Leishmania infantum</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[PARASITOS TRIPANOSOMATIDOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[TRYPANOSOMA BRUCEI]]></dcterms:subject>
    <dcterms:subject><![CDATA[LEISHMANIASIS]]></dcterms:subject>
    <dcterms:subject><![CDATA[RUTENIO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2022]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Human African trypanosomiasis (sleeping sickness) and leishmaniasis are prevalent zoonotic diseases caused by genomically related trypanosomatid protozoan parasites (Trypanosoma brucei and Leishmania spp). Additionally, both are co-endemic in certain regions of the world. Only a small number of old drugs exist for their treatment, with most of them sharing poor safety, efficacy, and pharmacokinetic profiles. In this work, new multifunctional Ru(II) ferrocenyl compounds were rationally designed as potential agents against these trypanosomatid parasites by including in a single molecule 1,1&prime; -bis(diphenylphosphino)ferrocene (dppf) and two bioactive bidentate li gands: 8-hydroxyquinoline derivatives (8HQs) and polypyridyl ligands (NN). Three [Ru(8HQs)(dppf)(NN)](PF6) compounds were synthesized and fully characterized. They showed in vitro activity on bloodstream Trypanosoma brucei (IC50 140&ndash;310 nM) and on Leishmania infantum promastigotes (IC50 3.0&ndash;4.8 &mu;M). The compounds showed good selectivity towards T. brucei in respect to J774 murine macrophages as mammalian cell model (SI 15&ndash;38). Changing hexafluorophosphate counterion by chloride led to a three-fold increase in activity on both parasites and to a two to three-fold increase in selectivity towards the pathogens. The compounds affect in vitro at least the targets of the individual bioactive moieties included in the new chemical entities: DNA and generation of ROS. The compounds are stable in solution and are more lipophilic than the free bioactive ligands. No clear correlation between lipophilicity, interaction with DNA or generation of ROS and activity was detected, which agrees with their overall similar anti-trypanosoma potency and selectivity. These compounds are promising candidates for further drug development.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?f5ef40434911dfee97e2be5485a30004e6d60e924764e90565526508d7c4a9668551fcacd53ebb4b1eb636968edea655900b0a79d5deadf21168bb9074273476" target="_blank"><strong>Rivas, Feriannys</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?234d9e55464b427ee1f8c54174a6b189" target="_blank"><strong>Del M&aacute;rmol, Carolina</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?30f70e9dfd00c43ffab403face2bbb4fd0f8853410743d6fa48798782e4078d5bf0735c77ca026b5828f7194ff3401bbfd4bd422c0ea61fda7a3ceb0a5af09f8" target="_blank"><strong>Scalese, Gonzalo</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez D&iacute;az, Leticia</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Machado, Ignacio</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Blacque, Olivier</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Medeiros Pereyra, Andrea Lourdes</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Comini, Marcelo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://export.cvuy.uy/cv/?6bb5dcce3e2559101357796ca4a2b2d4c9ba6b3a978a0bd4c5dab0107081b73e1ff46dcf49a7de2b571ff7980c4a01789f09f1d7eac1b879a8553641f940b9a5" target="_blank"><strong>Gambino, Dinorah</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Inorganic Biochemistry,v. 237, 2022. -- e112016]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[13 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.1016/j.jinorgbio.2022.112016]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/1985">
    <dcterms:title><![CDATA[<strong>New Ni (II)- sulfonamide complexes : Synthesis, structural characterization and antibacterial properties. X-ray diffraction of [Ni(sulfisoxazole)2(H2o)4].2H2O and [Ni(sulfapyridine)2]</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[SULFONAMIDAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[COMPLEJOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[ANTIINFECCIOSOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[2008]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA]]></dcterms:subject>
    <dcterms:abstract><![CDATA[The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)2(H2O)4] &middot; 2H2O and [Ni(sulfapyridine)2] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)2(H2O)4] &middot; 2H2O crystallized in a monoclinic system, space group C2/c where the nickel ion was in a slightly distorted octahedral environment, coordinated with two sulfisoxazole molecules through the heterocyclic nitrogen and four water molecules. [Ni(sulfapyridine)2] crystallized in a orthorhombic crystal system, space group Pnab. The nickel ion was in a distorted octahedral environment, coordinated by two aryl amine N from two sulfonamides acting as monodentate ligands and four N atoms (two sulfonamidic N and two heterocyclic N) from two different sulfonamide molecules acting as bidentate ligands. Differential pulse voltammograms were recorded showing irreversible peaks at 1040 and 1070 mV, respectively, attributed to Ni(II)/Ni(III) process. [Ni(sulfisoxazole)2(H2O)4] &middot; 2H2O and [Ni(sulfapyridine)2] presented different antibacterial behavior against Staphylococcus aureus and Escherichia coli from the similar copper complexes and they were inactive against Mycobacterium tuberculosis.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Mondelli, Melina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Brune, Veronica</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Borthagaray, Graciela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ellena, Javier</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Nacimento, Otaciro R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Batista, Alzir A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="curr&iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042"><strong>Torre, Maria H.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Journal of Inorganic Biochemistry v. 102, no. 2, 2008. -- p.285-292]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2008]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[DOI: 10.1016/j.jinorgbio.2007.09.001]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6638">
    <dcterms:title><![CDATA[<strong>New nitric oxide-releasing compounds as promising anti-bladder cancer drugs</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CANCER DE VEJIGA]]></dcterms:subject>
    <dcterms:subject><![CDATA[FUROXANOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[OXIDO NITRICO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2023]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Bladder cancer is a worldwide problem and improved therapies are urgently needed. In the search for newer strong antitumor compounds, herein, we present the study of three nitric oxide-releasing compounds and evaluate them as possible therapies for this malignancy. Bladder cancer cell lines T24 and 253J were used to evaluate the antiproliferative, antimigratory, and genotoxic effects of compounds. Moreover, we determined the NF-&kappa;B pathway inhibition, and finally, the survivin downregulation exerted by our molecules. The results revealed that compounds 1 and 3 exerted a high antiproliferative activity against bladder cancer cells through DNA damage and survivin downregulation. In addition, compound 3 reduced bladder cancer cell migration. We found that nitric oxide donors are promising molecules for the development of a new therapeutic targeting the underlying mechanisms of tumorigenesis and progression of bladder cancer]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Varela Vega, Mar&iacute;a In&eacute;s</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>L&oacute;pez, Miriam</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ingold, Mariana</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Alem, Diego</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Perini, Valentina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Perelmuter, Karen</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Bollati Fogol&iacute;n, Mariela</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>L&oacute;pez, Gloria V.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Hern&aacute;ndez, Paola</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Biomedicines, v.11, n&deg;1, 2023]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2023]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong>&nbsp;de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:extent><![CDATA[18 p.]]></dcterms:extent>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3390/ biomedicines11010199]]></dcterms:identifier>
</rdf:Description></rdf:RDF>
