Secretion and detection of defensive compounds by the red flour beetle tribolium castaneum interacting with the insect pathogenic fungus beauveria bassiana]]> Información sobre Derechos de Autor

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La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

]]> Can children use the A-not a test?]]> results. A total of 126 children were involved in the study. They participated in three sessions, each composed of a familiarization task with a visual stimuli and sample tasting with
one of three dairy products (vanilla milk desserts, chocolate-flavored milk, and vanillaflavored yogurt). Half of the children evaluated the samples in terms of overall differences and the other half in terms of differences in liking. Results from the familiarization step showed that children correctly identified the visual reference in the A-not-A test regardless of how the question was framed, suggesting that they were able to understand the methodology. In the case of tasting samples, children were significantly more likely to correctly identify the reference in two of the three studied dairy products, when the question was based on liking, as compared to the framing based on overall differences.]]> Velázquez, Ana Laura]]> Vidal, Leticia]]> Varela, Paula]]> Ares, Gastón]]> Información sobre Derechos de Autor

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]]> Season and No-Till Rice Crop Intensification Affect Soil Microbial Populations Involved in CH4 and N2O Emissions]]> Fernández Scavino, Ana]]> Oreggioni, Daniela]]> Martínez Pereyra, Andrea]]> Tarlera, Silvana]]> Terra, José A.]]> Irisarri, María del Pilar]]>

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]]> Methanogenic community linked to organic acids fermentation from root exudates are affected by rice intensification in rotational soil systems]]> Pereira Mora, Luciana]]> Terra, José A.]]> Fernández Scavino, Ana]]>

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]]> Synthesis of Pyrethroids and Jasmonoids through Palladium-Catalyzed Cross-Coupling Reactions]]> Parpal, Florencia]]> Paullier, Ana Paula]]> Pandolfi, Enrique]]> Heguaburu, Viviana]]>

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]]> Synthetic Study of 5-Hydroxymethylfurfural in Groebke-Blackburn-Bienaymé Reaction]]> de la Sovera, Victoria]]> López, Gloria V.]]> Porcal, Williams]]>

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]]> Metabolic engineered E. coli for the production of (R)-1,2-propanediol from biodiesel derived glycerol]]> Rodríguez Giordano, Sonia]]>

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ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.

]]> Detection of organochlorine pesticides in water and biological matrix]]> Umpiérrez, Eleuterio F.]]> Díaz, Daniela Ariadna]]>

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]]> Consumer perspectives on the inclusion of nutritional warnings in retail food establishments ]]> El presente trabajo tuvo como objetivo evaluar la percepción de los consumidores uruguayos en relación a la implementación de advertencias nutricionales en cuatro puntos de venta de comida y generar ideas sobre cómo podría implementarse esta medida. Se realizó un estudio online con una muestra no probabilística de 547 participantes, reclutados utilizando publicidad en redes sociales. Los participantes indicaron su grado de acuerdo con la implementación de advertencias nutricionales en panaderías, rotiserías, lugares de venta de comida rápida y sitios de pedidos online, y proporcionaron ideas sobre cómo incluir esta inforamción en cada punto de venta. Los resultados sugieren que la población tiene una perecpeción positiva sobre la inclusión de advertencias nutricionales en puntos de venta de comida. Los participantes destacaron la importancia de incluir esta información en un lugar visible al momento de elegir los productos, de forma que pueda ser tenida en cuenta al tomar las decisiones. En particular, las vitrinas y la cartelería/pizarras fueron identificados como lugaresestatégicos para la inclusión de advertencias nutricionales en panaderías/rotiserías y puntos de venta de comida rápida, respectivamente. Los resultados proporcionan valiosa información para extender la inclusión de advertencias nutricionales a puntos de venta de comida.]]> Antúnez, Lucía]]> Curutchet, María Rosa]]> Moratorio, Ximena]]> Giménez, Ana]]> Ares, Gastón]]> Información sobre Derechos de Autor

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]]> Straightforward sample preparation method for the analysis of pesticide residues in ginger (Zingiber officinale Rosc.) using gas chromatography-tandem mass spectrometry]]> Zingiber officinale Rosc., “ginger”, is widely cropped for its use as a spice and raw material for phytotherapeuticals. During cropping or post-harvest, different phytosanitary products are used, whose residues can be found in the final product, lowering the, quality and safety of the raw material. To detect those residues, a multi-contaminant methodology for GC–MS/MS analysis was developed and validated. For the selection of most suitable methodology, the performance of three methods in the determination of 39 analytes were compared: QuEChERS, QuEChERS AOAC 2007.01, and a modification of the AcOEt method, based on the inclusion of Al₂(SO₄)₃ in the extraction step to form stable and ethyl acetate insoluble Aluminum- (gingerols and/or polyphenols) complexes, lowering the co-extractives load injected in the instrument. Compared to the Acetonitrile based methods, the AcOEt method showed the best performance as 95% of the targeted analytes yielded recoveries between 70 and 120 and 80% of them between 90 and 110%). The method was validated for 57 contaminant residues by GC–MS/MS. The figures of merit (media of recoveries 96% and RSD 16%, back calculated concentration < 20%, matrix effects > 100%, linearity 5–300 μkg-¹) of the method accomplished the SANTE guidelines and the LOQs for all compounds (10-25μkg^-1) were below the ginger MRLs defined by food and medicinal herbs regulations, to ensure its safe consumption.

]]> Gérez García, Natalia]]> Zinola, Gianna]]> Macías, Gonzalo]]> Cesio, María Verónica]]> Heinzen, Horacio]]> Información sobre Derechos de Autor

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]]> Design and construction of a low-cost, in-situ analyzer for nutrients in surface waters, based on open-source hardware and software]]> This paper explains the design and construction of an automated analyzer for the in-situ determination of nutrients in surface waters. The analyzer is based on a pulsed flow analysis system employing solenoid micropumps and uses photometric detection based on LEDs and photodiodes. The analytes it determines are orthophosphate, nitrite and nitrate. The analyzer was programmed to perform a complete analysis cycle every 6 h. The end user receives the information from the analyzer via text messages (SMS), a service available even in rural and less developed areas, and requiring simple (non-smart) cell phones. The linear range was up to 25 mg L^-1P for phosphate, up to 1600 μg L^-1N-NO₂for nitrite, and up to 2500 μg L^-1N-NO₃for nitrite plus nitrate. The detection limits for each analyte were 0.28 mg L^-1P for phosphate, 19 μg L^-1N-NO₂for nitrite and 26 μg L^-1N-NO₃for nitrite plus nitrate. The analyzer can perform analysis cycles every 6 h with an autonomy of one week. It is suitable as a versatile analytical platform for environmental research.

]]> González, Pablo]]> Pérez, Nicolás]]> Knochen, Moisés]]>

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]]> Flavonoids and limonoids profiles variation in leaves from mandarin cultivars and its relationship with alternate bearing]]> Alternate bearing in citrus trees has been extensively studied as a key feature for citrus growers. Although the genetic and the biochemical process occurring during alternate bearing has been studied extensively, there is a lack of information identifying the presence of metabolic indicators during “on” and “off” years. In citrus plants, leaves play a central role in the metabolic pathway triggering the flflowering induction process. To investigate the changes during this transition, a liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analysis of the leaf profifiles of 20 compounds (17 polyphenols, two limonoids, and one furanocoumarin), in bearing and non-bearing branches arising from four different mandarin genotypes, was performed. The same metabolites were found in all the genotypes at both stages: both limonoids and 11 polyphenols.

Using these compounds, the chemotaxonomic differentiation between cultivars was assessed. The levels of flflavanones and limonoids showed differences in both bearing stages and the transition from vegetative to flflowering could be shown by the activation of the polyphenol biosynthetic pathway, from precursors like naringenin to metabolic end-points such as narirutin and polymethoxyflflavones.

Narirutin levels showed signifificant differences between both stages, suggesting it as a possible marker of the physiological status of the branch.

]]> Rodríguez Ceraolo, Cecilia]]> Vázquez, Valeria]]> Migues, Ignacio]]> Cesio, María Verónica]]> Rivas, Fernando]]> Heinzen, Horacio]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Iboga inspired N-Indolylethyl-Substituted isoquinuclidines as a bioactive scaffold: chemoenzymatic synthesis and characterization as GDNF releasers and antitrypanosoma agents]]> The first stage of the drug discovery process involves the identification of small compounds with biological activity. Iboga alkaloids are monoterpene indole alkaloids (MIAs) containing a fused isoquinuclidine-tetrahydroazepine ring. Both the natural products and the iboga-inspired synthetic analogs have shown a wide variety of biological activities. Herein, we describe the chemoenzymatic preparation of a small library of novel N-indolylethyl-substituted isoquinuclidines as iboga-inspired
compounds, using toluene as a starting material and an imine Diels–Alder reaction as the key step in the synthesis. The new iboga series was investigated for its potential to promote the release of glial cell line-derived neurotrophic factor (GDNF) by C6 glioma cells, and to inhibit the growth of infective trypanosomes. GDNF is a neurotrophic factor widely recognized by its crucial role in development, survival, maintenance, and protection of dopaminergic neuronal circuitries affected in
several neurological and psychiatric pathologies. Four compounds of the series showed promising activity as GDNF releasers, and a leading structure (compound 11) was identified for further studies. The same four compounds impaired the growth of bloodstream Trypanosoma brucei brucei (EC50
1–8 uM) and two of them (compounds 6 and 14) showed a good selectivity index.

]]> Mariana, Pazos]]> Dibello, Estefanía]]> Mesa, Juan Manuel]]> Sames, Dalibor]]> Comini, Marcelo Alberto]]> Seoane, Gustavo]]> Carrera, Ignacio]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Text highlighting as a new way of measuring consumers’ attitudes: a case study on vertical farming]]> Attitude measurement occupies a central position in consumer research. Concerns over the validity and reliability of traditional measures have motivated the development of alternative approaches. The present research introduces text highlighting as a method for measurement of explicit attitudes using a case study on vertical farming (VF) with 837 UK consumers. They participated in an online survey, where they read a text about VF and used highlighting functions to mark text as ‘like’ and ‘dislike.’ Consumers approached the task in a systematic
and logical way and desirable aspects of VF were frequently highlighted as ‘like’, whereas undesirable aspects were more frequently highlighted as ‘dislike’. The text highlighting responses were summarised using word clouds, frequency tables and through sentiment scores to reveal an overall positive attitude to VF among participants.
Sentiment scores enabled the identification of consumer segments with interpretable differences in their attitude towards VF. Two approaches to method validation – comparison with direct attitude questions and consumer profiling – further confirmed the potential of the text highlighting method. The sentiment of specific sentences in the text highlighting task matched results from self-reported attitudinal based on Likert scales. Consumer segments with different sentiment in the text highlighting task also differed in their food technology neophobia scores in the expected direction. Future research should investigate methodological aspects of text highlighting and explore its suitability to other applications.

]]> Jaeger, Sara R.]]> Chheang, Sok L.]]> Ares, Gastón]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> New silver(I) phosphino complexes : evaluation of their potential as prospective agents against Mycobacterium tuberculosis]]> Despite being a preventable and curable disease, Tuberculosis (TB) is the world's top infectious killer. Development of new drugs is urgently needed. In this work, the synthesis and characterization of new silver(I) complexes, that include N′ -[(E)-(pyridine-2-ylmethylene)pyrazine-2-carbohydrazide, HPCPH, as main ligand and substituted aryl-phosphines as auxiliary ligands, is reported. HPCPH was synthesized from pyrazinoic acid, the active metabolite of the first-line antimycobacterial drug pyrazinamide. Complexes [Ag(HPCPH)(PPh3)2]OTf (1), [Ag(HPCPH)((P(p-tolyl)3)2]OTf (2) and [Ag(HPCPH)(P(p-anisyl)3)2]OTf (3) were characterized in solid state and in solution by elemental analysis and FTIR and NMR spectroscopies (OTf––triflate). Crystal structures of (1,2) were determined by XRD. The Ag atom is coordinated to azomethine and pyridine nitrogen atoms of HPCPH ligand and to the phosphorous atom of each aryl-phosphine co-ligand. Although HPCPH did not show activity, the Ag(I) compounds demonstrated activity against Mycobacterium tuberculosis (MTB), H37Rv strain, and multidrug resistant clinical isolates (MDR-TB). Globally, results showed that the compounds are not only effective against the sensitive strain, but are more potent against MDR-TB than antimycobacterial drugs used in therapy.
The compounds showed low to moderate selectivity index values (SI) towards the bacteria, using MRC-5 cells (ATCC CCL-171) as mammalian cell model. Interaction with DNA was explored to get insight into the potential mechanism of action against the pathogen. No significant interaction was detected, allowing to discard this biomolecule as a potential molecular target. Compound 1 was identified as a hit compound (MIC90 2.23 μM; SI 4.4) to develop further chemical modifications in the search for new drugs.

]]> Maldonado, Yndira Dolores]]> Scalese, Gonzalo]]> Manieri, Karyn Fernanda]]> Pavan, Fernando R.]]> Aguirre Méndez, Larry D.]]> Gambino, Dinorah]]> Información sobre Derechos de Autor

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]]> Irabuena, Camila]]> Scarone, Laura]]> de Souza, Guilherme Eduardo]]> Campos Aguiar, Anna Caroline]]> Rossi Mendes, Giovana]]> Carvalho Guido, Rafael Victorio]]> Serra, Gloria]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> 10.1007/s00044-021-02843-1]]> New C9-polyacetylenes from the essential oil of the highly endangered species Baccharis palustris Heering (Asteraceae)]]> The essential oil composition of the aerial parts from Baccharis palustris Heering (Asteraceae), a highly endangered species, was analyzed by GC/qMS, GC/HRMS-TOF, FT-IR, UV–vis and NMR spectroscopy using 1D and 2D techniques. To our knowledge, this is the first report on the essential oil composition of B. palustris, as well as the first phytochemical study on this plant species. The volatile extracts were obtained from different phenologicals stages of plant, at flowering stage (FS) and vegetative stage (VS), where 51 components were identified accounting for 96.3 % and 99.0 % of the oil, respectively. The oil was rich in polyacetylene compounds (> 75 %), being the main components identified the new natural C9-polyacetylenes 1-nonene-3,5-diyne (1, here named as
baccharisdiyne) (52.7–65.0 %), 1,7(Z)-nonadiene-3,5-diyne [2, 7(Z)-dehydro-baccharisdiyne] (14.4–17.8 %), and 1,7(E)-nonadiene-3,5-diyne [3, 7(E)-dehydro-baccharisdiyne] (1.5–2.4 %). In addition, the known polyacetylenic compounds (Z)-lachnophyllum acid methyl ester (4) (4.3–5.3 %) and (E)-lachnophyllum acid methyl ester (5) (0.2 %) were also identified. Moreover, GC/qMS analysis allowed the identification of other 46 components in the essential oil samples, mainly mono- and sesquiterpenoids. In B. palustris, C9-polyacetylenes
probably derive biogenetically from a C10 precursor: baccharisdiyne (1) would be derived from either or both
lachnophyllum methyl ester geometric isomers (4 or 5), by enzymatic hydrolysis followed by decarboxylation. Dehydro-baccharisdiynes (2 and 3) could be produced by a similar pathway starting from the corresponding matricaria acid methyl ester isomers, one of which was tentatively identified at trace-level in B. palustris essential oil.

]]> Minteguiaga, Manuel]]> Umpierrez, Noelia]]> Andrés González]]> Dellacassa, Eduardo]]> Catalán, César A. N.]]> Información sobre Derechos de Autor

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]]> Ingold, Mariana]]> de la Sovera, Victoria]]> Dapueto, Rosina]]> Hernández, Paola]]> Porcal, Williams]]> López, Gloria V.]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Lead determination by HG-MIP OES with nitrogen plasma after a variable optimization study]]> A hydride generation nitrogen microwave induced plasma optical emission spectrometry (HG-MIP OES) system was developed for lead determination. Plumbane chemical generation was performed using 0.045 mol L1 K3Fe(CN)6 as the additive in acidic medium and 2.0% w/v NaBH4 in 1% w/v NaOH as the reductant. The additivated sample and the reductant were pumped towards a cyclonic chamber where
hydride generation and separation from the solution occurred. Operating conditions such as the additive and reductant concentration, sample, reductant and nitrogen flow-rate, the cyclonic chamber stabilization time and the viewing position in the torch were optimized. A meticulous study of the variation of the nitrogen plasma response as a function of the hydrochloric acid concentration was carried out. The analytical performance of the method was studied and its applicability evaluated in
a Trace Element in Water Certified Reference Material and a Soil Reference Material. The method performance in terms of limits of detection and quantification (0.54 mg L1 and 1.8 mg L1 Pb, respectively) was found comparable to other atomic spectrometry techniques. This is to our knowledge the first research on the analytical performance of lead determination by PbH4 generation and determination by MIP OES.

]]> Mollo, Alicia]]> Sixto, Alexandra]]> Jofré, Florencia Cora]]> Pistón, Mariela]]> Savio, Marianela]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Hydrogen production via steam reforming of small organic compounds present in the aqueous fraction of bio-oil over Ni-La-Me catalysts (Me = Ce, Ti, Zr)]]> Biofuel production from biomass sources emerges as a promising alternative to solve the actual environmental crisis and lead to a transition to a carbon-free future. In this sense, hydrogen produced through steam reforming of a biomass-derived biofuel, such as bio-oil, appears as an interesting energetic vector. The aim of this work is the hydrogen production through steam reforming of small organic model compounds present in the aqueous fraction of bio-oil (ethanol, acetic acid, acetone) and, for a better approximation to a real system, emulate such aqueous fraction by a representative mixture of these. Ternary mixed oxides Ni-La-Me catalysts (Me = Ce, Ti, Zr) were prepared, characterized through X-ray diffraction, N2 adsorption–desorption isotherms, thermogravimetric analysis, cyclic voltammetry, and scanning electron microscopy, and tested in the steam reforming reactions. Results indicate that, due to the intrinsic H2O
adsorption capacity of ZrO2 as well to a higher number of oxygen vacancies in the catalyst structure, Ni-La-Zr presents interesting properties for its potential applicability as industrial catalyst for hydrogen production through steam reforming. On the other hand, the strong metal-support interactions on Ni-La-Ti led to a lower catalytic activity caused by a lower segregation of Ni crystallites from the mixed oxide structure.

]]> Musso, Mauricio]]> Veiga, Santiago]]> Pedromo, Federico]]> Rodríguez, Tania]]> Mazzei, Natalia]]> Decarlini, Bianca]]> Portugau, Patrice]]> Bussi, Juan]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> 10.1007/s13399-021-02296-x]]> The non-direct band gap in borate glasses: a brief discussion on analysis methodologies and its interpretation]]> There is great interest in the study of the optical properties of materials such as glasses, due to their possible technological applications and from a fundamental point of view. For this reason, an attempt has been made to advance the understanding of the existence of optical band gap in this type of material. In recent times, several ways of analyzing the dependence of the absorption coefficient with energy have been proposed. Using lead, strontium, and barium borate glasses as a model, this dependence has been analyzed. For this, we considered the glass structure and the corresponding crystal structure, and the value of the optical band gap energy has been discussed considering the theory of Mott and Davis and comparing with values of crystals and glasses of similar composition. Here, we used a correction method, that takes into account intrinsic defects, to obtain the values of optical band gap energies in the framework of a non-direct transition. We also include DFT simulations of the corresponding crystalline compounds and the band gap was evaluated. The absorption coefficient obtained from simulations shows the same trend that the experimental one.

]]> Rodríguez Chialanza, Mauiricio]]> Faccio, Ricardo]]> Bentos Pereira, Heinkel]]> Marotti, Ricardo]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Biterm topic modelling of responses to open-ended questions: a study with US consumers about vertical farming]]> The aim of the present work was to explore the potential of Biterm Topic Modelling (BTM) for analysing responses to open-ended survey questions in the pursuit of consumer insights. The selection of BTM was based on its suitability to the analysis of short texts compared to other approaches such as Latent Dirichlet Allocation. The empirical context was vertical farming (VF), which participants read a short text about and then answered a question about interest in buying fruits and vegetables from VF. The data came from US consumers (n = 1803) who provided answers with a median length of 9 words. Results were promising about the potential of BTM to uncover latent topics from responses to open-ended questions. The models predicted coherent and consistent topics relating to VF, including buying VF produce or not and year-round fruit and vegetable supply. Two variants of the text about VF were used (n ~ 900 per variant), and BTM models trained on responses to the variant which emphasised the possibility of using genetic engineering in VF consistently predicted topics related
to genetic engineering. Models trained on responses to the variant which emphasized urban production and reduction of carbon emissions linked to product transportation, consistently revealed topics associated to production, environment, and local farming. The major limitation was not taking account of sentiment in consumers’responses, an issue that BTM shares with other topic models. This is a significant hindrance in the efforts to rely on machine learning for consumer insights.

]]> Vidal, Leticia]]> Ares, Gastón]]> Jaeger, Sara R.]]> Información sobre Derechos de Autor

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ADVERTENCIA: La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.]]> Improving the in vitro dissolution rate and pharmacokinetic performance of fenbendazole in sheep using drug nanocrystals]]> Benzimidazole methylcarbamate anthelmintics, including fenbendazole (FBZ), have only limited water solubility and small differences in drug solubility may have a major influence on their absorption, pharmacokinetic behavior and anthelmintic efficacy. To improve FBZ water solubility and dissolution rate, novel self-dispersible nanocrystals (SDNCs) of FBZ were recently described. In this work, the pharmacokinetic behavior of the SDNCs of FBZ and Poloxamer 188 was compared against a physical mixture (PM) of its components. The experiment was
conducted following a crossover design with two different experimental phases. In phase I, sheep were treated with the SDNC (n = 3) or the PM (n = 3) formulations by the intraruminal route at the same dose rate (5 mg/kg). The treatment groups were reversed after a 7-days washout period. A non-compartmental analysis of the concentration in plasma versus time results showed that the calculated Cmax and AUC0-T were significantly higher (p < 0.05) for FBZ and its metabolites after the SDNC treatment compared to the PM (for FBZ: Cmax 0.346 μg/mL and AUC0-T 10.1 μg.h/mL after the SDNC vs Cmax 0.157 μg/mL and AUC0-T 5.1 μg.h/mL after the PM treatment). Additionally, population pharmacokinetic parameters of FBZ were estimated for the first time in sheep. In conclusion, the formulation of FBZ as SDNCs is a promising approach to improve FBZ dissolution reaching a higher drug plasma exposure in ruminants.

]]> Melian, María Elisa]]> Ibarra, Manuel]]> Ceballos, Laura]]> Paredes, Alejandro J.]]> Munguía, Beatriz]]> Faccio, Ricardo]]> Palma, Santiago]]> Álvarez, Luis Ignacio]]> Domínguez, Laura]]> Información sobre Derechos de Autor

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