1929-2004: 75 Años de la Facultad de Química, volviendo a las raíces.

]]> Moyna, Patrick

]]> Nieto, Alberto

]]> Información sobre Derechos de Autor

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La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes

(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

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]]> Determination of thermodynamic constants of cobalt fluoride by solid state electromotive force measurements in high temperature systems]]> Becaria, Susana]]> Dr. Chairman, N. Lofgren (Director de Tesis)
]]> Dr.Gold, M. (Director de Tesis)
]]> Dr.Fredenburg, R.L.(Director de Tesis)
]]> Información sobre Derechos de Autor

(Por favor lea este aviso antes de abrir los documentos u objetos)

La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.

]]> Effects of temperature and purity of magnesium sulfate during extraction of pesticide residues using the QuEChERS method

]]> Despite its many documented advantages, the
QuEChERS (Quick, Easy, Cheap, Effective, Rugged,
and Safe) sample preparation approach has
problems with a few unstable pesticides, partly
due to the exothermic reaction generated by the
use of anhydrous magnesium sulfate (anh. MgSO4) during extraction. These pesticides also tend to be difficult to analyze by GC/MS. The aim of this study was to evaluate the effect of temperature during the extraction process in a revised version of AOAC Official MethodSM 2007.01 using anh. MgSO4 ≥99% (fine powder) or ≥97% (granular) purity, and the use of an ice bath for particular unstable pesticides of interest (chlorothalonil, captan, captafol, folpet,
and the degradation products cis-1,2,3,6-
tetrahydrophthalimide and phthalimide). Recoveries of 38 representative pesticides were measured in limes and broccoli at different extraction conditions by LC/MS/MS and low-pressure GC/MS/MS. Results showed that the difference in temperature when using ≥99% versus ≥97% purity anh. MgSO4 was 6–9°C, which did not lead to significant differences in recoveries. The use of an ice bath aided recovery for some of the analytes in broccoli, but no significant differences were observed for limes, which already provided greater stability of the base-sensitive analytes due to acidity of the matrix.

]]> Geis Asteggiante, Lucía]]> Lehotay, Steven J]]> Heinzen, Horacio]]> Información sobre Derechos de Autor

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]]> Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity

]]> Marine natural products1 play an important role in drug development particularly in anticancer, antibiotics and antiparasitics drugs.2 Various bioactive cyanobacterial compounds exhibit unique structural features like cyclic peptides containing azole heterocycles. 3 It is well known that macrocyclic peptides can demonstrate drug-like physicochemical and pharmacokinetic properties such as good metabolic stability, solubility, lipophilicity and bioavailability.4 In addition, asymmetrical cyclopeptides are considered as new scaffolds for supramolecular chemistry and provides an important method for the development and preparation of nanoscale objects.5 Examples of azole cyclopeptides are aerucyclamide B (1),6 dendroamide A (2),7 and venturamide A (3),8 Figure 1. Aerucyclamide B was isolated in 2008 by Gademann and co-workers from the toxic freshwater cyanobacterium Microcystis aeruginosa PCC 7806 and displays potent and selective antiplasmodial activity against Plasmodium falciparum K1. This species is the most virulent of the genus Plasmodium and causes more than 95% of malaria-related morbidity and mortality. According to the World Health Organization 2011 report, there were an estimated 216 million episodes and 655000 deaths of malaria in 2010.9 Various antimalarial drugs are presently used for the treatment of this tropical disease, but the rapid spread of resistance seriously compromises their efficacy.10

]]> Peña, Stella]]> Scarone, Laura]]> Manta, Eduardo]]> Stewart, Lindsay]]> Yardley, Vanessa]]> Croft, Simon]]> Serra, Gloria]]> Información sobre Derechos de Autor

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]]> Dehydration of carbohydrates to 2-furaldehydes in ionic liquids by catalysis with ion exchange resins

]]> The dehydration of several sugars, including pentoses, hexoses, di, tri, and polysaccharides, in ionic liquids with acidic ion-exchange resins as heterogeneous catalysts was investigated. Good 2‐furaldehydes recovery yields, reaching 92% in some cases, were achieved when Dowex® 50W ion‐exchange resins and 1‐n‐butyl‐3‐ methylimidazoliumchloride ([C4mim]Cl)were used. Our results show that this aproach could represent a promising route towards the cost-efficient production of 2-furaldehydes from carbohydrate-based feedstocks

]]> Heguaburu, V.]]> Franco, J.]]> Reina, L.]]> Tabarez, C.]]> Moyna, Guillermo]]> Moyna, Patrick]]> Información sobre Derechos de Autor

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]]>

]]> Sensory profiling, the blurred line between sensory and consumer science : A review of novel methods for product characterization

]]> Sensory descriptive analysis is one of the most powerful, sophisticated and most extensively used tools in sensory science, which provides a complete description of the sensory characteristics of food products. Considering the economic and time consuming aspects of training assessor panels for descriptive analysis, several novel methodologies for sensory characterization have been developed in the last ten years. These methodologies are less time consuming, more flexible and can be used with semi trained assessors and even consumers, providing sensory maps very close to a classic descriptive analysis with highly trained panels. Novel techniques are based on different approaches: methods based on the evaluation of individual attributes (intensity scales, check-all-that-apply questions or CATA, flash profiling, paired comparisons); methods based on the evaluation of global differences (sorting, projective mapping or Napping®); methods based on the comparison with product references (polarized sensory positioning), and based on a free, global evaluation of the individual products (Open-ended questions). This review aims at reviewing theory, implementation, advantages and disadvantages of the novel product profiling techniques developed in the last ten years, discussing recommendations for their application.

]]> Varela, Paula]]> Ares, Gastón]]> Información sobre Derechos de Autor

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]]>

]]> Ruggednes testing and validation of a practical analytical method for >100 veterinary drug residues in bovine muscle by ultrahigh performance liquid chromatography tandem mass spectrometry]]> In this study, optimization, extension, and validation of a streamlined, qualitative and quantitative multiclass, multiresidue method was conducted to monitor >100 veterinary drug residues in meat using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). Optimization centered on extensive ruggedness evaluation of the method. Various clean-up sorbents were tested and the amount of co-extractives were weighed, matrix effects were measured using post-column infusion of representative analytes, the effect of extract dilution before injecting was studied, and analyte recoveries and reproducibilities were determined. In order to extend our previous method, more drug analytes were added that possessed a wider range of chemical properties, and a re-appraisal of different types of C18 in dispersive solid-phase extraction clean-up and mobile phases in UHPLC–MS/MS was done. Ultimately, end-capped C18 and post-column infusion of ammonium formate as an ionization enhancer for the late-eluting anthelmintics were found to give improved qualitative results for greater analytical scope. A multi-day, multi-analyst validation demonstrated that the final method is suitable for screening of 113 analytes, identifying 98 and quantifying (recoveries between 70–120% and RSD < 25%) 87 out of the 127 tested drugs at or below US regulatory tolerance levels in bovine muscle

]]> Geis Asteggiante, Lucía]]> Lehotay, S. J]]> Lightfield, A. R]]> Dutko, T]]> Ng, C]]> Bluhm, L]]> Información sobre Derechos de Autor

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]]> Reseña de las iniciativas y de los proyectos pro-creación Facultad.]]> Martínez, Andrés]]> Saldías, Sollo]]> Antognazza, Juan F.]]> Muiño, José]]> Sena, E. R.]]> Tornatore, Juan]]> .
]]> Información sobre Derechos de Autor

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]]> How is the stacking interaction of bilayer graphene affected by the presence of defects?

]]> The presence of Stone–Wales, single and double vacancy defect sites in bilayer graphene was studied by means of dispersion corrected density functional theory. Based on the analysis of the formation energies computed for monolayer and bilayer graphene, monovacancies are expected to be equally frequent in both materials. In the case of the single vacancy, the formation energy is barely affected by the second layer and so does the interlayer interaction energy. However, Stone–Wales and double vacancies may be expected to be more frequent in single layer graphene because their formation energies are expected to be lower as compared to bilayer graphene. Calculations employing very large unit cells would be interesting to reduce the effect of the incommensurability of the unit cells of perfect and defective graphene, and thus confirm the latter statement. The single and double vacancies have the similar formation energy in bilayer graphene but for monolayer graphene, the 5-8-5 divacancy is more stable by at least 0.7 eV, in contrast with recent results. The electronic properties of defective bilayer graphene are similar to those corresponding to monolayer graphene. Finally, we have shown that the magnetic moment of monolayer graphene with a monovacancy is smaller than that of bilayer graphene bearing the same defect, when the unit cell is optimized. Yet, if the unit cells are fixed, different outcomes can be obtained. If the unit cell of perfect graphene is employed the magnetic moment of bilayer graphene with a single vacancy is larger, but if the unit cell of monolayer graphene with a single vacancy is to be employed the magnetic moment of defective bilayer graphene becomes smaller than that of monolayer graphene with a monovacancy

]]> Denis, Pablo A.]]> Faccio, Ricardo]]> Iribarne Restuccia, Federico Pablo]]> Información sobre Derechos de Autor

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]]> Artículo

]]>

]]> An efficient route for the synthesis of chiral conduritol-derivative carboxamides via palladium-catalized aminocarbonylation of bromocyclohenetetraols

]]> A family of chiral conduritol-derivative carboxamides was synthesized through palladium-catalyzed aminocarbonylation of diastereoisomeric bromocyclohexenetetraols, previously prepared through biotransformation of bromobenzene by mutant strains of Pseudomonas putida F39/D. The coupling reactions of bromocyclohexenetetraols with CO and different amines, such as tert-butylamine, aniline, and piperidine, were performed in the presence of in situ generated Pd(0)/PPh3 catalyst. The methodology was applied to the corresponding iodo-cyclohexenetetraol derivative, using (L)-alanine and (L)-valine methyl ethers as N-nucleophiles. The resulting carboxamides were obtained in highly chemoselective reactions, isolated, and fully characterized

]]> Carrilho, Rui M. B]]> Heguaburu, Viviana]]> Schapiro, Valeria]]> Pandolfi Graziosi, Enrique]]> Kollár, L]]> Pereira, Mariette M]]> Información sobre Derechos de Autor

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]]>

]]> Síntesis, caracterización y estudio del mecanismo de las reacciones de hidrólisis ácida y básica de complejos aminados de cobalto (III)]]> Benzo Moreira, Fabián]]> Prof.I.Q Sienra, Beatriz (Directora de Tesis)
]]> Prof. I.Q. Kremer, Eduardo (Director de Tesis)
]]> Información sobre Derechos de Autor

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]]> Solution phase photolysis of 1, 2 dithiane alone and with single-walled carbon nanotubes]]> Photolysis of 1,2-dithiane (1) in acetonitrile with single walled carbon nanotubes (SWCNTs) was earlier reported to form thiolfunctionalized SWCNTs via the butane-1,4-dithiyl diradical (2). The present study shows that 2 instead undergoes a facile rearrangement to thiophane-2-thiol (6). This photoreaction is clean, rapid, and irreversible under 313 nm irradiation. The secondary photolysis of 6 with SWCNTs at a shorter wavelength (254 nm) leads to 2-thiophanyl radicals 8, which derivatize SWCNTs by covalent attachment. Pyrolysis of the resulting “sulfurized SWCNTs” affords a mixture of organosulfur compounds, including thiophene formed by dehydrogenation. An unknown additional mechanism causes high TGA weight loss and a large incorporation of sulfur. ■ INTRODUCTION Single-walled carbon nanotubes (SWCNTs) have been functionalized by a variety of methods,1−6 many of which involve free radicals.7−18 In 2006 and 2007, Nakamura and coworkers19,20 published an unusual functionalization approach based upon biradicals. Irradiation of cyclic disulfides, e.g., 1 generated dithiyl biradicals 2, which were claimed to attack SWCNTs and produce thiol-functionalized SWCNTs 4, as illustrated in Figure 1. Although thiol groups would be useful for attaching small molecules to SWCNTs,21,22 and indeed several sulfurderivatized carbon nanotubes have been reported,22−27 certain aspects of

]]> Engel, Paul S.]]> Gudimetla, Vittal B.]]> Gancheff, Jorge S.]]> Denis, Pablo A.]]> Información sobre Derechos de Autor

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]]>

]]> Mechanistic studies of the formation of cyclopropane-bearing systems through photoconversion of tropolone Diels-Alder adducts]]> Irradiation of alkyltropolone DielseAlder adducts bearing b,g-unsaturated ketone chromophores leads to fused polycyclic systems containing cyclopropane moieties in good yields. A detailed mechanistic study, which included the use of deuterium labeling in combination with HRMS and NMR experiments, revealed that the process is highly stereoselective, proceeds through the formation of allyl radical and ketene intermediates, and involves participation of the solvent.bsp;

]]> Tabarez, Carlos]]> Khrizman, Alexander]]> Moyna, Patrick]]> Moyna, Guillermo]]> Información sobre Derechos de Autor

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]]>

]]> Limonene oxidation by molecular oxygen under solvent-free conditions : the influence of peroxides and catalysis on the reaction rate]]> Liquid-phase oxidation of limonene was performed with molecular oxygen as the sole oxidizing agent under non-solvent conditions. The oxidation took place under atmospheric pressure and temperatures between 70 and 90 C in the presence of three different nickel–aluminium hydrotalcites. The final limonene conversion at 80 C and 6 h of reaction time was comprised between 40 and 50 %. Several oxygenated limonene derivatives such as endo- and exo-epoxides, carveol and carvone represent 45–60 % of the whole amount of products. In the absence of a catalyst, a higher initial content of peroxides in limonene lead to a higher reaction rate with no significant changes in product selectivities. Thermal decomposition of limonene peroxides took place as the initiation path of an autooxidation mechanism leading to the different products. The catalyst played an important role in the initial paths involving activation of both reactants as well as in the decomposition of limonene peroxide to form radicals.

]]> Pena, Andrés]]> Veiga, Santiago]]> Sapelli, Mariángeles]]> Martínez, Natalia]]> Dellacassa, Eduardo]]> Bussi, Juan]]> Información sobre Derechos de Autor

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]]>

]]> Sobre creación de la Facultad de Ciencias Químicas y Farmacéuticas: exposición al Poder Ejecutivo.]]> Blanco, Tomás S.]]> Saldías, Zoilo]]> Información sobre Derechos de Autor

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]]> Sobre creación de la Facultad de Ciencias Químicas y Farmacéuticas: informe de la Comisión Especial al Consejo de la Facultad de Medicina.]]> Peluffo, Antonio]]> Bacigalupi, Carlos]]> Bonavía, Pablo]]> Información sobre Derechos de Autor

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]]> Sobre creación de la Facultad de Ciencias Químicas y Farmacéuticas: los Profesores de Farmacia.]]> Giribaldo, Domingo]]> Lanza, José]]> Peluffo, Antonio]]> Peluffo, Pedro]]> Bocage, Armando
]]> Juliá, Ernesto R.]]> González, Matías]]> Coppetti, Víctor]]> Guglielmetti, G.]]> Bonavía, Pablo J.]]> Saldías, Zoilo]]> Información sobre Derechos de Autor

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]]> Sobre creación de la Facultad de Ciencias Químicas y Farmacéuticas: Informe de la Comisión de Instrucción Pública.]]> HISTORIA DE LA FACULTAD DE QUÍMICA

]]> Salterain, Joaquín de]]> Guerra, Ublado Ramón
]]> Olais, Jaime Ferrer]]> Rodó, José Enrique]]> Zorrilla, Alberto]]> Schinca, Francisco A.]]> Información sobre Derechos de Autor

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]]> Estudio de la ciclación de anillos tetrahidrofuránicos como precursores de Isolaulimalida]]> Brovetto, Margarita]]> Dr. Prof. Seoane, Gustavo (Director de Tesis)]]> Información sobre Derechos de Autor

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La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

]]> Monacita del Uruguay composición y procesamiento]]> Burastero, Juan José]]> Dr. Prof. Píriz McColl, Carlos ( Director de Tesis)]]> Información sobre Derechos de Autor

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]]> Diagnóstico y terapia de tumores mediante radiofármacos biológicamente específicos]]> Cabral González, Pablo]]> Dr. Savio, Eduardo (Director de Tesis)]]> Dra.Balter, Henia (Directora de Tesis)]]> Dr. Zalutsky, Michael (Director de Tesis)]]> Información sobre Derechos de Autor

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]]> Perspectives on what ruthenium based compounds could offer in the development of potential antiparasitic drugs

]]> Among the infectious illnesses designated by the World Health Organization (WHO) as neglected tropical diseases (NTDs), four illnesses are major health concerns in the developing world: malaria and three parasitic diseases caused by genetically related parasites belonging to the trypanosomatid genus and kinetoplastida order: American trypanosomiasis, human African trypanosomiasis and leishmaniasis. This review focuses on the most relevant efforts carried out to develop ruthenium compounds as potential agents for the treatment of these diseases. Those series of compounds for which especial efforts have been made to modify structures performing a sort of rational design and to identify their molecular targets and mode of action were emphasized. Aspects related with the potentialities and perspectives of ruthenium compounds for this particular inorganic medicinal chemistry field are also included

]]> Gambino, Dinorah]]> Otero Zubiaurre, Ana Lucía]]> Información sobre Derechos de Autor

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]]> Artículo

]]>

]]> Bismuthy tri-iodide nanoparticles synthesized from octadecene suspension]]> BiI3 is a semiconductor layered compound of growing interest for direct and digital imaging. This structure determines that bismuth tri-iodide crystals can grow with platelet habit. Thereby, we consider of great importance to study if such structure can determine nanoparticles of this material as well, that means, if such layers can be rolled in order to form nanotubes and/or nanorods. In light of this, the present work reports the synthesis of bismuth tri-iodide nanoparticles by the suspension method. Bi(NO3)3.5H2O, I2 and KI were used as source materials, and 1-octadecene was used as suspension agent. The intermediate and final synthesized compounds were characterized by Xray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Results clearly show that BiI3 nanoparticles can be synthesized by the suspension method, which means that the layer structure of these compounds can determine the growth of nanostructures. Nanoparticles of different sizes and morphologies were obtained, depending on the synthesis conditions. There has been not possible to control such conditions in order to obtain uniform size and morphology distributions. The use of these nanostructures may be an interesting way of improving nucleation and further growth of bismuth tri-iodide films

]]> Aguiar, Ivana]]> Fornaro, Laura]]> Información sobre Derechos de Autor

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]]> Profundización en el rol de los transportadores de membrana en la terapéutica farmacológica de la epilesia]]> Maldonado, Cecilia]]> Información sobre Derechos de Autor

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]]>

]]> Desarrollo y evaluación de complejos de metales de transición y ligandos nitroimidazólicos con potencial aplicación en medicina nuclear]]> Fernández, Soledad]]> Información sobre Derechos de Autor

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]]>