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                <text>&lt;strong&gt;Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses&lt;/strong&gt;</text>
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                <text>Commercially available saponins are extracted from Quillaja saponaria barks, being Quil A&amp;reg; the most widely used. Nanoparticulate immunostimulating complexes (ISCOMs or ISCOMATRIX) formulated with these, are able to stimulate strong humoral and cellular immune responses. Recently, we formulated novel ISCOMs replacing QuilA&amp;reg; by QB-90 (IQB-90), a Quillaja brasiliensis leaf-extracted saponin fraction, and reported that IQB-90 improved antigen uptake, and induced systemic and mucosal antibody production, and T-cell responses. However, its mechanism of action remains unclear. In this study we provide a deeper insight into the immune stimulatory properties of QB-90 and ISCOMATRIX-like based on this fraction (IMXQB-90). We show herein that, when used as a viral vaccine adjuvant, QB-90 promotes an &amp;ldquo;immunocompetent environment&amp;rdquo;. In addition, QB-90 and IMXQB-90 induce immune-cells recruitment at draining-lymph nodes and spleen. Subsequently, we prove that QB-90 or IMXQB-90 stimulated dendritic cells secret IL-1&amp;beta; by mechanisms involving Caspase-1/11 and MyD88 pathways, implying canonical inflammasome activation. Finally, both formulations induce a change in the expression of cytokines and chemokines coding genes, many of which are up-regulated. Findings reported here provide important insights into the molecular and cellular mechanisms underlying the adjuvant activity of Q. brasiliensis leaf-saponins and its respective nanoparticles.</text>
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                <text>&lt;strong&gt;Cibulski, Samuel Paulo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mourglia Ettlin, Gustavo Daniel.&lt;/strong&gt;</text>
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                <text>Scientific Reports v. 8, no. 1, 2018. --15p.-- e13582</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1038/s41598-018-31995-1</text>
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                <text>&lt;strong&gt;Leaf saponins of Quillaja brasiliensis enhance long-term specific immune responses and promote dose-sparing effect in BVDV experimental vaccines&lt;/strong&gt;</text>
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                <text>SAPONINAS</text>
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                <text>QUILLAJA BRASILIENSIS</text>
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                <text>Saponin-based adjuvants are promising adjuvants that enhance both humoral and T-cell-mediated immunity. One of the most used natural products as vaccine adjuvants are Quillaja saponaria bark saponins and its fraction named Quil A&amp;reg;. Despite that, its use has been restricted for human use due to safety issues. As an alternative, our group has been studying the congener species Quillaja brasiliensis saponins and its performance as vaccine adjuvants, which have shown to trigger humoral and cellular immune responses comparable to Quil A&amp;reg; but with milder side effects. Here, we studied a semi purified aqueous extract (AE) and a previously little characterized saponin-enriched fraction (QB-80) from Q. brasiliensis as vaccine adjuvants and an inactivated virus (bovine viral diarrhea virus, BVDV) antigen co-formulated in experimental vaccines in mice model. For the first time, we show the spectra pattern of the Q. brasiliensis saponins by MALDI-TOF, a novel and cost-effective method that could be used to characterize different batches during saponins production. Both AE and QB-80 exhibited noteworthy chemical similarities to Quil A&amp;reg;. In addition, the haemolytic activity and toxicity were assessed, showing that both AE and QB-80 were less toxic than Quil A&amp;reg;. When subcutaneously inoculated in mice, both fractions promoted long-term strong antibody responses encompassing specific IgG1 and IgG2a, enhanced the avidity of IgG antibodies, induced a robust DTH reaction and significantly increased IFN-ɣ production in T CD4+ and T CD8+ cells. Furthermore, we have proven herein that AE has the potential to promote dose-sparing, substantially reducing the dose of antigen required for the BVDV vaccines and still eliciting a mixed Th1/Th2 strong immune response. Based on these results, and considering that AE is a raw extract, easier and cheaper to produce than commercially available saponins, this product can be considered as candidate to be escalated from experimental to industrial uses.</text>
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                <text>&lt;strong&gt;Cibulski, Samuel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Su&amp;aacute;rez, Norma&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Pirez, Macarena&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rossi, Silvina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gosmann, Grace&lt;/strong&gt;</text>
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                <text>Vaccine&amp;nbsp; v. 36, 2018. -- p. 55-65</text>
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            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="495468">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Berberine is an isoquinoline alkaloid with multiple pharmacological actions, including an anti-inflammatory activity. The effects of berberine on in-vitro cellular proliferation of human peripheral lymphocytes stimulated with phytohaemagglutinin, concanavalin A and pokeweed mitogen were studied. Mononuclear cells were cultured in flat-bottomed 96-well microplates at 37&amp;deg;C for 96&amp;ndash;144 h in the presence of one mitogen at different concentrations and the alkaloid at doses of 2.5 to 20 &amp;mu;gmL&amp;minus;1. The mitogen-induced response of lymphocytes was evaluated from the extent of the incorporation of [3H]thymidine into cells in-vitro. A consistent and progressive inhibitory influence of berberine with increasing concentrations in culture was identified with all mitogens and was more pronounced with pokeweed mitogen. The effect of berberine was observed in phytohaemagglutinin (PHA)- and concanavalin A-activated lymphocytes when the drug was added during the first 24 h of culture, whereas the same effect occurred throughout the incubation period in pokeweed mitogen-stimulated cells. The viability of lymphocytes following treatment with the drug, as assessed by the trypan blue exclusion test, revealed no change when compared with the same untreated lymphocytes, indicating no lymphocytotoxic activity. We conclude that some effects of berberine, especially its anti-inflammatory action, may arise in part from the inhibition of DNA-synthesis in activated lymphocytes.</text>
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&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Intermittent drainage is one of the most promising approaches to mitigate methane (CH 4 ) emission from paddy fi elds. Irrigated rice fi elds in Uruguay are temporarily established on soils used as cattle pastures. We studied soil from the pasture-rice rotation (UR) as well as soil from a permanent cattle pasture (UT) hypothesizing that activity and structure of the bacterial and archaeal communities involved in pro- duction of CH 4 change systematically with intermittent drainage. Methane production started after 7 days and 16 days of anoxic incubation in UR and UT soil, respectively. Then, production rates of CH 4 were higher in UT than UR soil. Intermittent drainage signi fi cantly decreased the rates of CH 4 production. Analysis of d 13 C indicated that CH 4 was mainly produced from acetate both in UR (73 e 98%) and UT (51 e 80%) soil. Intermittent drainage did not change the pathway of CH 4 production. Quantitative PCR showed that methanogenic archaeal gene copy numbers (16S rRNA, mcrA ) were much lower in UT than UR soil, but increased upon incubation under anoxic conditions. Terminal restriction fragment length polymorphism (T-RFLP) and pyrosequencing of bacterial and archaeal 16S rRNA genes showed that the communities were clearly different between UR and UT soil. The bacterial community consisted of 9 phyla with relative abundance of &amp;gt; 1% in both soils. Whereas the archaeal community in UR soil was dominated by Methanocellales and Methanosarcinaceae , that in UT soil was dominated by Crenarchaeota . Anoxic incubation affected the composition of the bacterial and archaeal communities in UT soil, but not so much in UR soil. In UT soil, the relative abundance of Clostridiales increased to 19%, and the archaeal community changed to dominance by Methanosarcinaceae and Methanobacteriales . Subsequent drainage and re- fl ooding, however, had comparatively little effect on the composition, although it decreased the rates of CH 4 production in both soils. Difference in previous soil management and in the structures of the microbial communities apparently only affected their dynamics and functioning after the fi rst fl ooding but not upon subsequent drainage and re- fl oodin</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>University students&amp;rsquo; academic achievement measured by means of academic progress is modeled through linear and logistic regression, employing prior achievement and demographic factors as predictors. The main aim of the present paper is to compare results yielded by both statistical procedures, in order to identify the most suitable approach in terms of goodness of fit and predictive power. Grades awarded in basic scientific courses and demographic variables were entered into the models at the first step. Two hypotheses are proposed: (a) Grades in basic courses as well as demographic factors are directly related to academic progress, and (b) Logistic regression is more appropriate than linear regression due to its higher predictive power. Results partially confirm the first prediction, as grades are positively related to progress. However, not all demographic factors considered proved to be good predictors. With regard to the second hypothesis, logistic regression was shown to be a better approach than linear regression, yielding more stable estimates with regard to the presence of ill-fitting patterns.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>&lt;strong&gt;Coello Garc&amp;iacute;a, M. T.&lt;/strong&gt;</text>
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                <text>Spanish Journal of Psychology v. 11, no. 1, 2008. -- p. 275-288</text>
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                <text>Universidad Complutense de Madrid</text>
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                <text>In order to rationalize the available data related to the antichagasic activity of Pt/Pd complexes containing 5-nitrofurylthiosemicarbazones, in the present work we carried out a PCM/DFT comparative characterization of 16 Pt(II)/Pd(II) compounds of general formula [MCl2L] and the corresponding 5- nitrofurylthiosemicarbazone ligands (L) using multivariate techniques to sort and classify them and to search for patterns correlating the biological activity with calculated physicochemical descriptors. The data allow us to rationally propose that these compounds might act through dual or even multiple mechanisms of action, with preferred paths that depend on both the nature of metal and ligand. Moreover, these results suggest that the complexes in the set would not react in vivo with DNA, being biotransformed earlier, before gaining access to nuclear DNA in the cell. The binding mode and inhibitory potency of a selection of metal complexes and ligands with Trypanosoma cruzi cruzipain and trypanothione reductase enzymes is also modeled through molecular docking.</text>
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                <text>&lt;strong&gt;Merlino Mellognio, Alicia Beatriz&lt;/strong&gt;</text>
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                <text>European Journal of Medicinal Chemistry v. 46 , no. 7, 2011. -- p. 2639-2651</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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                <text>Recently developed semiempirical methods (AM1, MNDO-PM3 and MNDO/M) are tested by comparison with ab initio Hartree-Fock and M&amp;oslash;ller-Plesset 4-31G and 6-311G (d,p) calculations on cuts of the potential energy hyperfaces of the hydrogen bonded dimers H2O&amp;middot;H2O, NH3&amp;middot;NH3 and NH3&amp;middot;H2O. AM1 gives a bifurcatedly hydrogen-bonded complex for the water dimer, as already published, whereas it gives trifurcated structures for the other two dimers. There is no indication of a quasi-linear hydrogen bonded dimer in these last two cases, in agreement with the ab initio calculations. Moreover, there is a secondary minimum in the ammonia dinner surface, with a cyclic structure, which closely resembles that obtained in the ab initio calculations. MNDO-PM3 gives the quasi-linear hydrogen bonded structure of the water dimer as the correct one. For NH3&amp;middot;NH3 the global minimum is no longer the trifurcated structure (which is, however, a secondary minimum) but a cyclic one. However, the ring is so closed that hydrogen atoms of both monomers are almost head-to-head. For NH3&amp;middot;H2O a further minimum appears, which is now the global one, corresponding to the linearly hydrogen-bonded structure of the dimer. The aspect of this attractor, as well as the aspect of the cut in the PES of the water dimer, suggests that undue importance has been given to linear hydrogen bonds in the parametrization of MNDO-PM3. MNDO/M behaves in a very similar way to MNDO-PM3 and, owing to its better definition, the latter should be preferred. In conclusion, none of these methods is truly reliable for calculations on weakly bound dimers. MNDO-PM3 is better than AMI for the water and the ammonia-water dimers but not for the ammonia dimer; MNDO/M is no better than MNDO-PM3.</text>
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                <text>Recently proposed modified MNDO methods (MNDO/M and MNDO-PM3) for the study of hydrogen-bonded complexes are tested in four simple systems: (H2O)2, NH4+ &amp;middot; H2O, formamide water and formamide-methanol dimers. A comparison is made with AM1 since this method, intended to be a general improvement of MNDO, was already shown to fail in the former two dimers. Bifurcated hydrogen-bonded structures were always preferred over linear ones. AM1 also shows this artifact in the formamide-water dimer but not in the formamide-methanol one. This is due to the inability of -CH3 to bind to the carbonyl oxygen. In this case the AM1 optimized global minimum is in excellent agreement with the Hartree-Fock ab initio DZP optimized structure. Moreover, when it is physically impossible to form bifurcated hydrogen bonds, AM1 is in good agreement with ab initio results. MNDO/M and MNDO-PM3 (an improvement on AM1 ) do not give any bifurcated structure either in the former two dimers or in the formamide complexes. MNDO/M and MNDO-PM3 structures are in agreement with ab initio and experimental ones in almost all cases, except for the global minima in both the formamide-water and the formamide- methanol dimers. Singly hydrogen-bonded structures are predicted instead of the experimentally determined and ab initio calculated correct doubly hydrogen-bonded ones. MNDO-PM3, although not entirely correct, gives structures which are more correct than the MNDO/M ones. In conclusion, neither of these semiempirical methods is entirely correct. Overall, MNDO-PM3 seems to be more trustworthy than AM1 or MNDO/M, although these methods may be used when no bifurcated hydrogen bonds (AM1) or cycles (MNDO//M) exist. Failures of MNDO-PM3 indicate that a better semiempirical method is still needed for studies of solvation and hydrogen- bonded clusters.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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