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                <text>&lt;strong&gt;Latent subgroups of cognitive performance in lead- and manganese-exposed Uruguayan children : Examining behavioral signatures&lt;/strong&gt;</text>
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                <text>OBJECTIVES: Lead (Pb) and manganese (Mn) are confirmed neurotoxins but it is unclear to what extent low-level exposure produces a unique behavioral signature. The objective of this study was to investigate latent cognitive profiles among children (6-8 years) from Montevideo, Uruguay co-exposed to these metals. METHOD: Among 345 children, blood Pb and hair Mn were measured using atomic absorption spectroscopy and ICP-MS, respectively. Sixteen measures, reflecting multiple domains of cognitive functioning were gathered: (1) three tests from Cambridge Neuropsychological Test Automated Battery (CANTAB): Intra-Extra Dimensional Shift (IED), Spatial Span (SSP) and Stockings of Cambridge (SOC), (2) ten tasks from Woodcock-Mu&amp;ntilde;oz Achievement Battery, Revised (WM): Visual-Motor Integration, Verbal Comprehension (Vocabulary, Synonyms, Antonyms, Analogies), Visual-Auditory Comprehension, Concept Formation, Visual Spatial Thinking, Number Inversion and Spatial Relations, (3) Bender Gestalt task, and (4) Weschler block design task. Scores were modeled using latent profile analysis (LPA). Association between blood Pb and hair Mn on performance profiles was assessed using ordinal regression, controlling for confounders. An interaction between Pb and Mn was tested. RESULTS: Mean&amp;thinsp;&amp;plusmn;&amp;thinsp;SD of blood Pb was 4.1&amp;thinsp;&amp;plusmn;&amp;thinsp;2.1&amp;thinsp;&amp;mu;g/dL and 35% of children had blood Pb &amp;ge; 5&amp;thinsp;&amp;mu;g/dL. Median [5%, 95%] hair Mn level was 0.8 [0.3, 4.1] ppb. Three latent cognitive performance profiles were identified: high (n&amp;thinsp;=&amp;thinsp;46, 13%), average (n&amp;thinsp;=&amp;thinsp;209, 61%) and low (n&amp;thinsp;=&amp;thinsp;90, 26%). Each one-unit increase in blood Pb was associated with a 28% greater likelihood of belonging to a poorer-performing profile. The association was non-linear, with the effect of Pb on profile membership strongest at lower levels of exposure. There was no meaningful interaction between Pb and Mn. CONCLUSIONS: A behavioral signature for low-level Pb &amp;amp; Mn exposure was not identified, but the likelihood of membership in low-performing profile was higher at lowest levels of blood Pb. There was no effect measure modification between Pb and Mn. Future research should address how complex environments created by chemical exposures and the social context relate to cognitive performance in young children</text>
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                <text>&lt;strong&gt;Frndak, Seth&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Barg Beltrame, Gabriel.&lt;/strong&gt;</text>
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                <text>Neurotoxicology v. 73, 2019. -- p. 188-198</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1016/j.neuro.2019.04.004</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Metarhizium (Nomuraea) rileyi as biological control agent&lt;/strong&gt;</text>
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                <text>CONTROL DE PLAGAS</text>
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                <text>METARHIZIUM</text>
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                <text>Metarhizium rileyi is an entomopathogenic fungus of Lepidoptera and infects many noctuids, which are key pests of agricultural crops. In this literature review, we summarise the state of art and use of this potential biological pest control agent. Pathogen&amp;ndash;host interactions include conidial adhesion, invasion process, and enzymatic activity. Environmental factors that impact the productivity associated with this fungus such as environment temperature, humidity, and availability of spores are discussed. Recent research has focused on enzymatic aspects related to pathogenicity, in which the cause is not fully elucidated yet. More than 60 known host species, mainly lepidopterans, are listed. Non-susceptible species, including predatory insects, are also presented. The difficulty of mass production and the formulation are the principal obstacles in use of M. rileyi. We summarise the challenges necessary to better utilise this agent in biocontrol and suggest novel research approaches, including the development of commercial and technically viable formulations.</text>
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                <text>&lt;strong&gt;Fronza, Edegar&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Specht, Alexandre&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=0f8b88f1a07d7ad1bd23900b47efb225" target="_self"&gt;&lt;strong&gt;Heinzen, Horacio.&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Biocontrol Science and Technology v.27, no. 11, 2017. -- p. 1243-1264</text>
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                <text>Taylor and Francis Group</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Often referred to as the “king of cancers” pancreatic cancer is a serious threat to public health, as most cases are diagnosed at an advanced stage. Although tumor immunotherapy is a major advancement in cancer treatment, its effectiveness in pancreatic cancer remains limited, particularly owing to the unique characteristics of the tumor microenvironment. Nano-delivery systems offer a promising approach for overcoming the dense stromal barrier, which is crucial for enhancing the therapeutic efficacy. In this review, we systematically summarize key immunotherapeutic targets, including cancer-associated fibroblast (CAF), immune cells (tumor-associated macrophage (TAM), myeloid-derived suppressor cell (MDSC), regulatory T cells (Treg), tumor-associated neutrophil (TAN), CD4+T, CD8+T cells), extracellular matrix (ECM), and discussed regulatory strategies in pancreatic cancer based on its pathogenesis and recent clinical advances to guide target selection. We then detail the physicochemical properties of nano-delivery systems suitable for pancreatic cancer and outline how tumor microenvironment-responsive linkers can enable particle size or charge conversion. Furthermore, we review the latest research progress on various nano-delivery systems (Lipid-based nanoparticle, Hydrogel/microneedle, Inorganic nanoparticle, Cancer vaccine, Adoptive cell therapy, Exosome/vesicle, Bacteria/virus) to inform the design of pancreatic cancer nanocarriers. Finally, we discuss future directions and summarize the challenges in translating pancreatic cancer nano-delivery systems into clinical practice. By integrating target identification, nanocarrier design, and clinical applications, we aimed to provide a cohesive framework that offers insights to accelerate the development of effective pancreatic cancer therapies.</text>
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&lt;p&gt;&lt;strong&gt;La legislación uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;
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                <text>Dalton Transactions v. 42, 2013. -- p. 6021-6032</text>
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                <text>&lt;strong&gt;Vasorelaxant Effect of a Baccharis trimera Infusion on Precontracted Rat Aortic Rings&lt;/strong&gt;</text>
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                <text>Baccharis trimera (Less.) DC is a South American plant that in folk medicine is considered to produce reduction in blood pressure. One aspect of this putative effect is the vasorelaxation. The aim of this work was to evaluate the ability of a B. trimera extract to relax rat aortic rings precontracted with noradrenaline. As the infusion is the usual way of intake of this plant, an infusion of B. trimera was prepared using 100g of the plant (leaves) boiled in water, frozen and lyophilized. Working solutions were prepared using different concentrations of the dried extract diluted in Krebs Henseleit solution. It was proved that the infusion relaxed the aortic rings in a dose dependent manner 100 minutes after adding the extract to the bath. Considering as 100% the maximum contraction achieved with noradrenaline, a relaxation of 101.1&amp;plusmn;2.3% was observed with the highest dose of the infusion used in these experiments (0.32mg/mL). While in control rings relaxation was 12.9&amp;plusmn;2.4%. In aortic rings denuded from endothelium the percentage of vasoralaxation did not show statistically significant differences when compared to intact rings. These data support the hypothesis of a vasorelaxant effect of this plant and constitutes the first approach to the scientific basis of a potential antihypertensive effect. Keywords: Hypertension, Cardiovascular, Traditional medicine, Meso-and Southtern American, Baccharis trimera, Vasorelaxation, Aortic rings. Discover the world's research</text>
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                <text>&lt;strong&gt;G&amp;oacute;mez, Mar&amp;iacute;a A.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Miguez, Ignacio&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Arias, Ximena&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Migliaro, Eduardo R.&lt;/strong&gt;</text>
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                <text>Natural Product Communications v. 11, no. 3, 2016. -- p. 283-286</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Seed oils recovered from industrial fruit by-products are a rich source of tocopherols and tocotrienols : Rapid separation of &amp;alpha;/&amp;beta;/&amp;gamma;/&amp;delta; homologues by RP-HPLC/FLD&lt;/strong&gt;</text>
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                <text>FRUTAS</text>
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                <text>ACEITES DE SEMILLAS</text>
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                <text>TOCOFEROLES</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>The profiles of tocopherols and tocotrienols (vitamin E) in the seed oils recovered from apple (Malus domestica Borkh.), canary melon (Cucumis melo L.), gooseberry (Ribes uva-crispa L.), grape (Vitis vinifera L.), Japanese quince (Chaenomeles japonica), pomegranate (Punica granatum L.), red currant (Ribes rubrum L.), sea buckthorn (Hippophae rhamnoides L.), and watermelon (Citrullus lanatus) by-products of the fruit industry were studied. The highest concentration of tocochromanols was found in pomegranate seed oil (398.73&amp;thinsp;mg/100&amp;thinsp;g) and the lowest in gooseberry seed oil (69.13&amp;thinsp;mg/100&amp;thinsp;g). The &amp;gamma; and &amp;alpha; homologues were the predominant forms of tocopherol and tocotrienol in all fruit seed oils studied. The pomegranate, canary melon, watermelon, gooseberry and red currants seed oils contained mainly &amp;gamma;-tocopherol (382.69, 63.08, 111.01, 60.35, and 156.39&amp;thinsp;mg/100&amp;thinsp;g, respectively). In the apple, sea buckthorn and Japanese quince seed oils, &amp;alpha;-tocopherol was the predominant tocochromanol (58.77, 121.79, and 198.94&amp;thinsp;mg/100&amp;thinsp;g, respectively). High concentrations of tocotrienol homologes (&amp;gamma; and &amp;alpha;) (49.49 and 34.53&amp;thinsp;mg/100&amp;thinsp;g, respectively) were found only in grape seed oil. A significant correlation (r&amp;thinsp;=&amp;thinsp;0.994, p&amp;thinsp;&amp;lt;&amp;thinsp;0.00001) between the total content of tocochromanols in the seed oils and scavenging of the free radical DPPH was found</text>
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                <text>&lt;strong&gt;G&amp;oacute;rnas , P.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Soliven, Arianne&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Seglina, D.&lt;/strong&gt;</text>
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                <text>European Journal of Lipid Science and Technology v. 117, no. 6, 2015. -- p. 773-777</text>
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                <text>Wiley Online Library</text>
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                <text>&lt;strong&gt;Seed oils recovered from industrial fruit by-products are a rich source of tocopherols and tocotrienols : Rapid separation of &amp;alpha;/&amp;beta;/&amp;gamma;/&amp;delta; homologues by RP-HPLC/FLD&lt;/strong&gt;</text>
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                <text>ACEITES DE SEMILLAS</text>
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                <text>The profiles of tocopherols and tocotrienols (vitamin E) in the seed oils recovered from apple (Malus domestica Borkh.), canary melon (Cucumis melo L.), gooseberry (Ribes uva-crispa L.), grape (Vitis vinifera L.), Japanese quince (Chaenomeles japonica), pomegranate (Punica granatum L.), red currant (Ribes rubrum L.), sea buckthorn (Hippophae rhamnoides L.), and watermelon (Citrullus lanatus) by-products of the fruit industry were studied. The highest concentration of tocochromanols was found in pomegranate seed oil (398.73&amp;thinsp;mg/100&amp;thinsp;g) and the lowest in gooseberry seed oil (69.13&amp;thinsp;mg/100&amp;thinsp;g). The &amp;gamma; and &amp;alpha; homologues were the predominant forms of tocopherol and tocotrienol in all fruit seed oils studied. The pomegranate, canary melon, watermelon, gooseberry and red currants seed oils contained mainly &amp;gamma;-tocopherol (382.69, 63.08, 111.01, 60.35, and 156.39&amp;thinsp;mg/100&amp;thinsp;g, respectively). In the apple, sea buckthorn and Japanese quince seed oils, &amp;alpha;-tocopherol was the predominant tocochromanol (58.77, 121.79, and 198.94&amp;thinsp;mg/100&amp;thinsp;g, respectively). High concentrations of tocotrienol homologes (&amp;gamma; and &amp;alpha;) (49.49 and 34.53&amp;thinsp;mg/100&amp;thinsp;g, respectively) were found only in grape seed oil. A significant correlation (r&amp;thinsp;=&amp;thinsp;0.994, p&amp;thinsp;&amp;lt;&amp;thinsp;0.00001) between the total content of tocochromanols in the seed oils and scavenging of the free radical DPPH was found.</text>
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                <text>&lt;strong&gt;G&amp;oacute;rnas , P.&lt;/strong&gt;</text>
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                <text>European Journal of Lipid Science and Technology v. 117, no. 6, 2015. -- p. 773-777</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>CROMATOGRAFIA LIQUIDA DE ALTA PRESION</text>
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                <text>Composition of tocochromanols in kernels recovered from 16 different apricot varieties (Prunus armeniaca L.) was studied. Three tocopherol (T) homologues, namely &amp;alpha;, &amp;gamma; and &amp;delta;, were quantified in all tested samples by an RP-HPLC/FLD method. The &amp;gamma;-T was the main tocopherol homologue identified in apricot kernels and constituted approximately 93% of total detected tocopherols. The RP-UPLC-ESI/MSn method detected trace amounts of two tocotrienol homologues &amp;alpha; and &amp;gamma; in the apricot kernels. The concentration of individual tocopherol homologues in kernels of different apricots varieties, expressed in mg/100 g dwb, was in the following range: 1.38&amp;ndash;4.41 (&amp;alpha;-T), 42.48&amp;ndash;73.27 (&amp;gamma;-T) and 0.77&amp;ndash;2.09 (&amp;delta;-T). Moreover, the ratio between individual tocopherol homologues &amp;alpha;:&amp;gamma;:&amp;delta; was nearly constant in all varieties and amounted to approximately 2:39:1.</text>
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                <text>&lt;strong&gt;Mi&amp;scaron;ina, I.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gravite, I.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Kaufmane, E.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Seglina, D.&lt;/strong&gt;</text>
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                <text>Natural Product Research v. 29, no. 13, 2015. -- p. 1222-1227&#13;
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                <text>Taylor, Francis Online</text>
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                <text>Tocopherol separations employing the same Kinetex&amp;trade; C18 column via supercritical fluid chromatography (SFC) and reversed-phase liquid chromatography (RP-LC) were compared. The application of the SFC system with UV diode array detection (DAD) resulted in rapid separation of all four tocopherol homologues with a total analysis time below 2&amp;thinsp;min. The RP-LC approach could not separate the isomers &amp;beta; and &amp;gamma;. The developed SFC-DAD method was precise, accurate, and most importantly more environmentally friendlier compared to the RP-LC method due to the 125-fold decrease in methanol consumption. The present study illustrated the selectivity differences between LC and SFC and how the C18 column can be used for tocopherol characterization. The optimized SFC method was successfully applied for the tocopherol determination in the seeds of nine different fruit species.</text>
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                <text>&lt;strong&gt;Urvaka, Elise&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Misina, Inga&lt;/strong&gt;</text>
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                <text>Journal of Chemistry 2019. -- p. 1-10. --e5307340</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1155/2019/5307340</text>
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                <text>&lt;strong&gt;Effect of Solanum glycoalkaloids on potato aphid : Macrosiphum euphorbiae.&lt;/strong&gt;</text>
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                <text>MACROSIPHUM EUPHORBIAE</text>
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                <text>TOMATIDINA</text>
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                <text>GLICOALCALOIDES</text>
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                <text>URUGUAY</text>
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                <text>Macrosiphum euphorbiae, also known as the potato aphid, is a potato virus vector, associated with decreased tuber production. Feeding, toxicity, and reproductive effects of the major potato glycoalkaloids (&amp;alpha;-chaconine and &amp;alpha;-solanine), their common aglycone (solanidine), and a nonpotato glycoalkaloid (&amp;alpha;-tomatine) and its aglycone (tomatidine) onM. euphorbiae were studied. As expected, neither &amp;alpha;-chaconine nor &amp;alpha;-solanine had a strong lethal effect on the aphid, but &amp;alpha;-chaconine stimulated feeding at low concentrations. Both aglycones were deterrent and lethal at high concentrations and, like &amp;alpha;-chaconine and &amp;alpha;-tomatine, they delayed the appearance and decreased the number of nymphs.</text>
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                <text>&lt;strong&gt;G&amp;uuml;nther, Carlos&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Dos Reis, Renato&lt;/strong&gt;</text>
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                <text>Journal of Chemical Ecology v. 23, no. 6, 1997. -- p. 1651-1659</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The design and the execution of a multi-generation approach to pyrrolizidine alkaloids is summarized. A historical perspective and the various solutions to the problems of regio-, stereo-, and enantiocontrol in the preparation of these ubiquitous natural products are provided. The details of the fourth generation approach based on the resolution of &amp;szlig;-oxo esters of prochiral alcohols by yeast are disclosed. As this particular approach did not (we think) lead to optically pure products, a fifth-generation solution to the problems that were encountered is proposed. 1. Introduction 2. Historical Perspective 3. Regiochemistry of the [4 + 1] Intramolecular Pyrroline Annulation 4. Stereochemical Control in the Pyrrolizidine Diol Series 5. Enantiocontrolled Approach to Pyrrolizidine Triols 6. Attempted Enantiocontrolled Approach to Pyrrolizidine Diols 7. Conclusion</text>
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            <description>A name given to the resource</description>
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            <name>Publisher</name>
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          <element elementId="47">
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            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="636685">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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