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                <text>Several radiolabeled alpha-melanocyte stimulating hormone (&amp;alpha;-MSH) analogs have been studied for their abilities to target melanoma tumor cells through specific recognition and binding to the melanocortin receptor 1 (MCR1). In this work, a lactam bridgecyclized &amp;alpha;-MSH analog was labeled with 99m via the hydrazinonicotinamide (HYNIC) chelator and characterized for its melanoma tumor targeting properties. The bifunctional chelating agent HYNIC-Boc was attached to the N-terminus of the MSH peptide followed by the lactam cyclization, resulting in the HYNIC-cyc-MSH analog. The lactam cyclized peptide displayed high affinity and specificity for MC1-receptors present on B16/F1 melanoma tumor cells, exhibiting an IC50 of 6.48 nM. HYNIC-cyc-MSH was radiolabeled with 99mTc using two common co-ligands, tricine and EDDA. In vitro, the radiochemical stability, cell binding and efflux properties were similar between the peptides radiolabeled with tricine and EDDA as co-ligands. In vivo, biodistribution studies (n=4) demonstrated that 99mTc- HYNIC-cyc-MSH/tricine had superior tumor to muscle and tumor to blood ratios than 99mTc-HYNIC-cyc-MSH/EDDA at early time points. Planar gamma imaging of melanoma bearing mice showed that 99mTc-HYNIC-cyc-MSH/tricine was able to clearly visualize tumors, underscoring the potential utility of 99mTc labeled lactam cyclized MSH molecules as melanoma imaging agents. - See more at: http://www.eurekaselect.com/124097/article#sthash.esh9JhlX.dpuf</text>
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                <text>&lt;strong&gt;Zhang, Xiuli&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fern&amp;aacute;ndez Silveira, Marcelo.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Moreno, Mar&amp;iacute;a&lt;/strong&gt;</text>
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                <text>Anti-Cancer Agents in Medicinal Chemistry v.15, no. 1, 2015. -- p. 122-130</text>
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                <text>Bentham Science</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>ISSN: 1875-5992 (En l&amp;iacute;nea)</text>
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              <description>An account of the resource</description>
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                <text>&lt;strong&gt;68Ga-DOTATATE PET/CT in the evaluation of patients with neuroendocrine metastatic carcinoma of unknown origin&lt;/strong&gt;</text>
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                <text>NEOPLASMAS</text>
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                <text>TUMOR NEUROENDOCRINO</text>
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                <text>OBJECTIVE: There is little evidence regarding the role of (68)Ga-DOTATATE PET/CT for the identification of primary tumors in patients with metastatic neuroendocrine carcinoma of unknown primary. The aim of this study is to assess the value of this technique in the mentioned clinical scenario. METHODS: We retrospectively studied twenty-nine patients (mean age 59.5 &amp;plusmn; 10.6 years; female 17) with pathologically proven neuroendocrine metastases. In all cases conventional imaging was negative for primary tumor identification. (68)Ga-DOTATATE PET/CT was performed with a mean dose of 104.2 &amp;plusmn; 18.8 MBq, using a 64-slice PET/CT with time-of-flight correction. A team of an experienced radiologist and a nuclear medicine physician evaluated the images. The maximum SUV (SUVm) was measured in all abnormal foci. Histopathology (when available) and/or clinical follow-up with correlative imaging was considered as reference standard. RESULTS: (68)Ga-DOTATATE PET/CT identified the primary tumor in 17/29 (59%) patients in the following locations: pancreas (n = 7), ileum (n = 7), duodenum (n = 1), colon (n = 1) and stomach (n = 1). In this population a significant correlation was found between SUVm of primary tumor and metastases (r = 0.815, P &amp;lt; 0.0001). Furthermore, additional sites of unsuspected metastases were demonstrated in 9 patients of this group and in 6 patients in whom no primary tumor was localized, mainly in lymph nodes and mesentery. Pathology confirmation was obtained in 7 patients who underwent surgery, whereas in the remaining 10 patients, correlative imaging and follow-up confirmed primary tumor localization. CONCLUSIONS: (68)Ga-DOTATATE PET/CT is a clinically useful imaging technique for the localization of primary tumors in patients with neuroendocrine metastatic carcinoma of unknown origin with the potential of having a significant impact in patient management and therapy planning.</text>
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                <text>&lt;strong&gt;Alonso, Omar&lt;/strong&gt;</text>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1023bf078c82efde0baa86eb3a1163e6" target="_blank"&gt;&lt;strong&gt;Savio, Eduardo&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Bentancourt, Cecilia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gambini, Juan&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Engler, Henry&lt;/strong&gt;</text>
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                <text>Annals of Nuclear Medicine v. 28, no. 7, 2014. -- p. 638-645</text>
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                <text>Springer Japan</text>
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                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
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                <text>A nivel internacional existen importantes avances en el estudio de granos y harinas de diferentes cereales. En particular el estudio en trigo ha estado vinculado a las modificaciones en las propiedades reol&amp;oacute;gicas de las masas formadas a partir de las harinas de este en funci&amp;oacute;n del contenido proteico. Existen tambi&amp;eacute;n estudios que vinculan a componentes minoritarios, los arabinoxilanos, en relaci&amp;oacute;n a las propiedades anteriormente indicadas, donde las evidencias seg&amp;uacute;n los diferente autores, resulta contradictoria. Estas contradicciones posiblemente se deben a que las investigaciones generalmente estudian el efecto del agregado de compuestos aislados en lugar de estudiar el efecto en las variaciones de los mismos presentes en las harinas. En nuestro pa&amp;iacute;s, este trabajo es la primera aproximaci&amp;oacute;n a evaluar la influencia de la composici&amp;oacute;n qu&amp;iacute;mica de los carbohidratos no amil&amp;aacute;ceos sobre los par&amp;aacute;metros tradicionalmente asociados a la calidad panadera de las harinas de variedades locales. Se seleccionaron harinas representativas de la variabilidad local con respecto a los principales par&amp;aacute;metros predictores de calidad, con contenidos de prote&amp;iacute;nas de acuerdo a los requerimientos para su comercializaci&amp;oacute;n, de las cuales se encontr&amp;oacute; que, en su mayor&amp;iacute;a, desarrollar&amp;aacute;n el gluten de manera adecuada durante el amasado. Se encontr&amp;oacute; que el volumen del pan, la formaci&amp;oacute;n del gluten y la proporci&amp;oacute;n de prote&amp;iacute;nas que lo forman son afectados negativamente por los arabinoxilanos, posiblemente por la competencia en la absorci&amp;oacute;n de agua durante el amasado la cual es afectada por las propiedades estructurales de &amp;eacute;stos &amp;uacute;ltimos, tanto por sus ramificaciones como por la presencia de &amp;aacute;cidos fen&amp;oacute;licos que influyen sobre su capacidad para formar agregados durante el amasado. Se determinaron asimismo variaciones estructurales en los arabinoxilanos por el proceso de amasado y panificaci&amp;oacute;n con el agregado de enzimas espec&amp;iacute;ficas confirmando la influencia sobre las interacciones que ocurren entre estos componentes minoritarios y el gluten. Se encontr&amp;oacute; que las muestras demasiado el&amp;aacute;sticas que resisten a ser extendidas presentan mayores contenidos de arabinoxilanos insolubles. Del an&amp;aacute;lisis de componentes principales se encontr&amp;oacute; que la cantidad y estructura de arabinoxilanos resultan de gran importancia en el conjunto de las variables y presentan una fuerte relaci&amp;oacute;n inversa con respecto a la extensibilidad de las masas</text>
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                <text>&lt;p&gt;In the search for new therapeutic tools against Chagas' disease (American Trypanosomiasis) four novel mixed-ligand vanadyl complexes, [V(IV)O(L(2)-2H)(L(1))], including a bidentate polypyridyl DNA intercalator (L(1)) and a tridentate salycylaldehyde semicarbazone derivative (L(2)) as ligands were synthesized, characterized by a combination of techniques, and in vitro evaluated. EPR suggest a distorted octahedral geometry with the tridentate semicarbazone occupying three equatorial positions and the polypyridyl ligand coordinated in an equatorial/axial mode. Both complexes including dipyrido[3,2-a: 2',3'-c]phenazine (dppz) as polypyridyl coligand showed IC(50) values in the muM range against Dm28c strain (epimastigotes) of Trypanosoma cruzi, causative agent of the disease, being as active as the anti-trypanosomal reference drug Nifurtimox. To get an insight into the trypanocidal mechanism of action of these compounds, DNA was evaluated as a potential parasite target and EPR, and (51)V NMR experiments were also carried out upon aging aerated solutions of the complexes. Data obtained by electrophoretic analysis suggest that the mechanism of action of these complexes could include DNA interactions.&lt;/p&gt;</text>
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                <text>In the search for new therapeutic tools against Chagas disease (American trypanosomiasis) palladium and platinum complexes of the bioactive ligand pyridine-2-thiol N-oxide were exhaustively characterized and evaluated in vitro. Both complexes showed high in vitro growth inhibition activity (IC50 values in the nanomolar range) against Trypanosoma cruzi, the causative agent of the disease. They were 39&amp;ndash;115 times more active than the antitrypanosomal drug Nifurtimox. The palladium complex showed an approximately threefold enhancement of the activity compared with the parent compound. In addition, owing to their low unspecific cytotoxicity on mammalian cells, the complexes showed a highly selective antiparasite activity. To get an insight into the mechanism of action of these compounds, DNA, redox metabolism (intraparasite free-radical production) and two parasite-specific enzymes absent in the host, namely, trypanothione reductase and NADH-fumarate reductase, were evaluated as potential parasite targets. Additionally, the effect of metal coordination on the free radical scavenger capacity previously reported for the free ligand was studied. All the data strongly suggest that trypanocidal action of the complexes could mainly rely on the inhibition of the parasite-specific enzyme NADH-fumarate reductase.</text>
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                <text>JBIC, Journal of Biological Inorganic Chemistry v. 13, no.5, 2008 . -- p. 723-735</text>
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                <text>Nuclei from Echinococcus granulosus protoscolices were isolated from infected sheep. Protein extracts were prepared for analysis of DNA-protein interactions involving specific transcriptional regulatory factors. Gel mobility-shift assays were done using a heterologous probe containing binding sites for widespread transcription factors. A fragment of the promoter of GATA-1 transcription factor from the chicken was selected. When nuclear extracts from E. granulosus protoscolices were assayed a specific band shift was observed. The methodologies developed in this study could provide an important contribution for the characterization of the DNA-protein interactions involved in transcriptional regulation within the context of recent developments in the molecular biology of this parasite.</text>
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                <text>Parasitology Research v.84, no.7, 1998. -- p. 598-600</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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                <text>Journal of Helminthology v. 71, no. 4, 1997. -- p. 355-358</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Searching for new promising metal-based drugs for the treatment of parasitic diseases against Trypanosoma cruzi, three related oxidovanadium(IV) complexes, [VIVO(SO4)(H2O)2(NN)], with the phenanthroline derivatives (NN) 1,2,5thiadiazolo[3,4-f]1,10phenanthroline (tdzp), 1,10-phenanthroline-5, 6-dione (phendione), and 5,6-epoxy-5,6-dihydro-1,10-phenanthroline (epoxyphen) are synthesized, characterized, and evaluated in vitro as anti-T. cruzi agents. The compounds are characterized in the solid state and in solution by elemental analysis, electrospray ionization mass spectrometry (ESI-MS), conductimetric measurements, and infrared (FTIR), UV/Vis, and electronic paramagnetic resonance (EPR) spectroscopy. EPR spectroscopy suggests that the ligands act as bidentate, binding through both nitrogen donor atoms in an axial-equatorial mode. DFT calculations corroborate the structural assignments. The stability of the complexes in solution is evaluated by EPR and 51V- NMR spectroscopy and all complexes show reasonable stability. The anti-T. cruzi activity of the complexes was tested by measuring the growth inhibitory effect on the epimastigote life cycle form of the parasite (Dm28c strain). All complexes show IC50 values in the micromolar range against T. cruzi and display activities of the same order of that of Nifurtimox, but lower than that of the previously reported analogue [VIVO(SO4)(H2O)2(dppz)] (dppz = dipyrido[3, 2-a:2&amp;prime;,3&amp;prime;-c]phenazine). Furthermore, DNA was evaluated as a potential target by using atomic force microscopy (AFM), showing that the complexes display ability to interact with this biomolecule.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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                <text>Casiope&amp;iacute;nas&amp;reg; are mixed-chelate copper complexes with antitumor tested potential. Their activity, both in vitro and in vivo, as antiproliferative, cytotoxic, and genotoxic drugs has been assessed. Biological results of these copper compounds have deserved some of them entering clinical trials. Significant efforts have been devoted to the in-depth identification of their mechanism of action. Using gel electrophoresis analysis, we have previously shown that the interaction of the Casiope&amp;iacute;nas&amp;reg; Cas II-gly, [Cu(4,7-dimethyl-1,10- phenanthroline)(glycinate)]NO3 with DNA, triggers the cleavage of the biomolecule by a free radical mechanism. In this work, we further study the behavior of different complexes of the same Casiope&amp;iacute;nas&amp;reg; series also including glycinate as co-ligand {Cas VI-gly (5,6 dimethyl-1,10- phenanthroline glycinato copper(II) nitrate), Cas VII-gly (1,10-phenanthroline glycinato copper(II) nitrate), and Cas IX-gly (2,2&amp;prime;-bipyridine glycinato copper(II) nitrate)} and of a Casiope&amp;iacute;nas&amp;reg; with a different co-ligand (Cas III-Cs; 4,7-dimethyl- 1,10-phenanthroline salicylaldehydato-copper(II) nitrate). While all of them produce DNA degradation, the performance in the presence of a radical scavenger suggests the existence of differences in their mechanism of interaction with DNA.</text>
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                <text>Biological Trace Element Research v. 161, no. 2, 2014. -- p. 210-215</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Micro and/or nano encapsulated salts and spices are generating eminent contribution to aimed 27 taste development in food items. The bioactive compounds and flavor making ingredients of 28 different herbs and spices are sheltered by loading in encapsulated systems. The main 29 privileges of encapsulated spices are maintaining the quality and quantity of functional 30 compartments, reducing germ count without chemical strategies or irradiation and alleviating 31 enzymatic reactions. Encapsulated salts are also interesting category applied in wide range of 32 food products for both dietary reasons and industrial functional applications e.g. meat 33 products, bakery goods and seasonings to decrease the negative effects on meat-protein 34 interactions, keep down freeze/thaw temperatures, expand the efficiency of microorganisms 35 (yeasts) and postpone staling. The current chapter is aimed to investigate the mode of action 36 and importance of encapsulated ingredients in salts, spices, and seasonings formulations.&#13;
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                <text>&lt;strong&gt;Chemical characterization and in vitro anthelmintic activity of Citrus bergamia Risso and Citrus X paradisii Macfad essential oil against Haemonchus contortus Kirby isolate&lt;/strong&gt;</text>
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                <text>&lt;p&gt;Haemonchus contortus, a blood-sucking parasite of small ruminants, produces very important economic losses in the productive sector. This abomasum parasite has become resistant to most commercial drugs worldwide, and alternatives to fight this problem are urgently needed. Essential oils (EO) are a complex mixture of volatile secondary metabolites, composed mainly by terpenoids and phenolic compounds, from plants that have several pharmacological properties, including anthelmintic activity. Particularly, citrus peel is a source of cold-pressed EO, where limonene is its major component, and can be used as an additional food component for ruminants. The&lt;br /&gt;aim of the present work was to determine the in vitro anthelmintic activity of EO from Citrus bergamia (EOB), C. x&lt;br /&gt;paradisii (EOG) and limonene against the benzimidazole-susceptible Kirby isolate of H. contortus, using the egg hatch test (EHT) and the exsheathed third stage larval motility test (XLMT) using a WMicroTracker equipment. Albendazole (ABZ) and monepantel (MON) were used as positive controls. The 50% inhibitory concentrations (IC50) in XLMT were 8.77 and 13.88 &amp;mu;g/ml for EOB and EOG respectively, after an incubation of 72 h. An interesting observation on XLMT resulted when the positive controls were tested on the same plate, but in different well of the EOB. The volatile components of the EO significantly influenced (P &amp;lt; 0.05) the percentage of larval motility, reducing values from 66.9 to 19.6% for ABZ, and from 72.8 to 33.7% for MON, when comparing the activity of positive controls in a control plate without EO. The in vitro anthelmintic activity of EOB and EOG shows that they could be interesting candidates for nematode control. It is still necessary additional studies&lt;br /&gt;against the adult stage of H. contortus in efficacy trials in infected animals to validate their anthelmintic activity.&lt;/p&gt;</text>
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                <text>In spite of the great advances in chemotherapeutics, infectious diseases are still one of the leading causes of death in the world. Amongst the most problematic clinically relevant pathogens at present, methicillin&amp;ndash;resistant Staphylococcus aureus (MRSA) ranks as one of the most difficult bacteria to treat. Interest in plants with antimicrobial properties has revived as a consequence of current problems associated with the use of antibiotics. The objective: was to evaluate the antibacterial activity of a compound isolated from Ibicella lutea (Lindl.) Van Eselt. (Martyniaceae) and some of its derivatives, against methicillin&amp;ndash;sensitive and MRSA. Compound 1 was isolated and identified as previously described and minimal inhibitory concentration (MIC) of 1 and simple analogs were determined by the microdilution technique. Compound 1 (11&amp;ndash;hydroxystearic acid 11&amp;ndash;0&amp;ndash;(6&amp;ndash;0&amp;ndash;acetyl&amp;ndash;&amp;beta;&amp;ndash;D&amp;ndash;grucopyranoside) showed a MIC of 0.06 mM for S. aureus ATCC 6538p. All the synthetic analogs and precursors presented higher MIC values. Compound 1 showed antimicrobial activity against different strains of MRSA. These results suggest that the glycosidic and acidic moieties are necessary for the antimicrobial activity under study.</text>
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                <text>&lt;strong&gt;Garc&amp;iacute;a da Rosa, Mar&amp;iacute;a Eloisa&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Olivaro, Cristina&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=52e013818d1066562588b928cb60fb7d"&gt;&lt;strong&gt;Cerdeiras, Mar&amp;iacute;a P&amp;iacute;a&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Revista Latinoamericana de Qu&amp;iacute;mica v. 38, no. 2, 2010. -- p.98-102</text>
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                <text>Laboratorios Mixim</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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                <text>Art&amp;iacute;culo</text>
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                <text>ISSN 0370-5943</text>
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        <name>Antibióticos</name>
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      <tag tagId="618">
        <name>Botánica</name>
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        <name>Enfermedades Bacterianas</name>
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        <name>Enfermedades infecciosas</name>
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        <name>Martyniaceae</name>
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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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          <name>Original Format</name>
          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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                <text>&lt;strong&gt;Evoluci&amp;oacute;n de la especie metoxi sobre La2O3&lt;/strong&gt;</text>
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            <description>The topic of the resource</description>
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            <description>A summary of the resource.</description>
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                <text>The mechanism of CH&lt;sub&gt;4&lt;/sub&gt; formation in industrial MeOH synthesis from CO and H using La&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt; catalyst is detd. by the catalyst compn., the reaction medium (H or inert gas), catalyst pretreatment with Pt, and hydration or carbonate or metal deposits on the catalyst. &amp;nbsp;The formation of CH&lt;sub&gt;4&lt;/sub&gt; via unstable &lt;span class="hit"&gt;methoxy&lt;/span&gt; &lt;span class="hit"&gt;species&lt;/span&gt; has a neg. effect on the MeOH reaction and adequate control of reaction conditions can minimize the side reaction.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>&lt;strong&gt;Garc&amp;iacute;a de P&amp;eacute;rez, Marisa&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Diano, Washington&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Menafra, Luis&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Kieffer, Roger&lt;/strong&gt;</text>
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                <text>Bolet&amp;iacute;n de la Sociedad Qu&amp;iacute;mica del Per&amp;uacute; v. 51, no. 3, 1985. -- p. 193-197</text>
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            <name>Publisher</name>
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                <text>Sociedad Qu&amp;iacute;mica del Per&amp;uacute;</text>
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                <text>&lt;p class="western" lang="es-ES" align="left"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p class="western" lang="es-ES"&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p class="western" lang="es-ES"&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p class="western" lang="es-ES"&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p class="western" style="margin-bottom: 0cm;" lang="es-ES"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>ISSN:0037-8623</text>
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                <text>&lt;strong&gt;3D-printed chemiluminescence flow cells with customized cross-section geometry for enhanced analytical performance&lt;/strong&gt;</text>
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                <text>Low force stereolithography is exploited for the first time for one-step facile fabrication of chemiluminescence (CL) flow-through cells that bear unrivalled features as compared to those available through milling or blowing procedures or alternative 3D printing technologies. A variety of bespoke cross-section geometries with poly hedral features (namely, triangular, square, and five-side polygon) as well as semicircular cross-section are herein critically evaluated in terms of analytical performance against the standardcircular cross-section in a flat spirally-shape format. The idea behind is to maximize capture of elicited light by the new designs while leveraging 3D printing further for fabrication of (i) customized gaskets that enable reliable attaching of the active mixing zone of the CL cell to the detection window, (ii) in-line 3D-printed serpentine reactors, and (iii) flow confluences with tailorable shapes for enhancing mixing of samples with CL reagents. Up to twenty transparent functional cells were simultaneously fabricated without inner supports following post-curing and surface treat ment protocols lasting less than 5 h. In fact, previous attempts to print spirally-shaped cells in one-step by resorting to less cost effective photopolymer inkjet printing technologies were unsuccessful because of the requirement of lengthy procedures (&amp;gt;15 days) for quantitative removal of the support material. By exploiting the phthalazinedione-hydrogen peroxide chemistry as a model reaction, the five-side irregular pentagon cell exhibited superior analytical figures of merit in terms of LOD, dynamic range and intermediate precision as compared to alternative designs.Computational fluid dynamic simulations for mapping velocities at the entry region of the spiral cell corroborated the fact that the 5-side polygon cross-section flow-cell with Y-type confluence permitted the most efficient mixing of reagents and sample while enabling larger flow velocities near the inlet that contribute to a more efficient capture of the photons from the flash-type reaction. The applicability of the 3D-printed 5-side polygon CL cell for automatic determination of hydrogen peroxide using a computerized hybrid flow system was demonstrated for the analysis of high matrix samples, viz., seawater and saliva, with relative recoveries ranging from 83 to 103%.</text>
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                <text>Talanta v. 255, 2023. -- e124211</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Paleolimnological data are presented on trophic development, climatic change and sea level variations in Negra Lagoon, a 142 km2 coastal lagoon in southern Uruguay. Using a sediment core that extended to the early Holocene, analyses of organic matter, carbonate, diatoms and opal phytoliths allowed us to track changes in trophic state and paleosalinity levels, which were closely related to Holocene sea level variation, temperature and humidity. Diatom Association Zones (DAZ) corresponding to transgressive events were dominated by marine/brackish taxa and relatively low organic matter values, while those DAZ corresponding to regressive events showed increases in brackish/freshwater diatoms and organic matter. Opal Phytoliths Association Zones (OPAZ) also were identified, temperature and humidity indices were calculated, and climatic trends were inferred. During the middle Holocene (i.e., �5000&amp;ndash;4000 yr BP), cool&amp;ndash;dry climatic conditions were established. After �4000 yr BP, a transition from cool to warm&amp;ndash;humid conditions was observed, but fully warm humid conditions established only after �1700 yr BP. Such climatic amelioration led to increases in trophic state.</text>
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                <text>Journal of Paleolimnology v.33, no.3, 2005. -- p. 253-263</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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                <text>Fish Physiology and Biochemistry v. 28, no. 1-4, 2003. -- p. 337-338</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The strong correspondence between the spatial arrangement of archaeological sites and wetland environments is one of the main axes of the Mer&amp;iacute;n Lagoon basin archaeology. Without implying a deterministic simplification from the epistemological point of view, the cultural and environmental history of the region hold evidence suggesting a more complex scenario, where cultural responses to climate change were not so mechanical or direct as previously argued. The relationship between paleoclimate and prehistoric mound builders development between 7.0 and 0.6 ka 14C BP was studied in SE Uruguay. Paleoclimatic data were inferred from the phytolith record of three lagoon sediment cores. Four paleoclimatic periods were identified according to temperature/humidity changes. The first period, dated at 7.0e4.5 ka 14C BP, was characterized by a warm/humid climate. Between 4.5 and 3.5 ka 14C BP, the onset of a cool/dry climate was inferred. A hiatus between 3.5 and 2.6 ka 14C BP was identified. In the third period, 2.5e1.2 ka 14C BP, similar climate conditions to those of the present were inferred. Finally, the period 1.2 and 0.6 ka 14C BP, was characterized by warmer and wetter conditions than those of the present. According to these data, it was determined that mounds were first observed during the transition from warm/humid to cool/dry conditions, but the complexity of the mounds increased after the full establishment of cool/dry conditions. With the inception of warm/humid conditions, an increased number of mounds was observed in the plains located close to the Mer&amp;iacute;n Lagoon littoral. The mounds showed lower density and height than those recorded for the cool/dry period. This behavioral modification in mound construction was explained because of the paleoenvironmental change</text>
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                <text>Quaternary International v.245, no. 1, 2011. -- p. 62-73</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;A multiproxy approach to inferring Holocene paleobotanical changes linked to sea-level variation, paleosalinity levels, and shallow lake alternative states in Negra Lagoon, SE Uruguay.&lt;/strong&gt;</text>
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                <text>Hydrobiologia v. 646, no. 1, 2010. -- p. 5-20</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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                <text>A convenient, instrumentally simple, and efficient methodology to transform 1,2-dihydropyridines into benzoic esters is described. The generated multisubstituted benzoic esters feature different topologies spanning from simple aromatic rings to fused benzocycloalkane systems. As an extension of this methodology, these benzoic esters are efficiently transformed into an array of fluorenone frameworks featuring interesting and novel topological patterns.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Las experiencias did&amp;aacute;cticas vividas en formaci&amp;oacute;n docente inicial tienen un fuerte impacto en la conformaci&amp;oacute;n del perfil profesional del profesor . En estas experiencias se deben ver claramente trabajados los grandes fines en la ense&amp;ntilde;anza de las ciencias: formar ciudadanos cr&amp;iacute;ticos, formar para la participaci&amp;oacute;n ciudadana, alfabetizar cient&amp;iacute; ficamente. La teniosis por solium, cisticercosis y triquinosis, son parasitosis en los humanos que se adquieren por consumo de carne de cerdo. En la formaci&amp;oacute;n inicial de docentes de Biolog&amp;iacute;a pa ra la ense&amp;ntilde;anza media, la s especies causantes de las parasitosis se estudian en la asignatura Zoolog&amp;iacute;a. Quebrando con el cl&amp;aacute;sico abordaje de temas program&amp;aacute;ticos siguiendo la l&amp;oacute;gica de la disciplin a, se realizaron en la as ignatura trabajos con un enfoque de tipo CTS. Se organiz&amp;oacute; la conformaci&amp;oacute;n de equipos en el grupo clase, uno de los cuales abord&amp;oacute; los helmintos par&amp;aacute;sitos transmitidos al hu mano por el cerdo. El trabajo incluy&amp;oacute; la realizaci&amp;oacute;n de una investigaci&amp;oacute;n bibliogr&amp;aacute;fica, re colecci&amp;oacute;n de informaci&amp;oacute;n en industrias locales que cr&amp;iacute;an cerdo, la producci&amp;oacute;n de una monogr af&amp;iacute;a y la presentaci&amp;oacute;n del tema a los dem&amp;aacute;s compa&amp;ntilde;eros de clase. Se vio el v&amp;iacute;nculo existente en tre la pr&amp;aacute;ctica religiosa jud&amp;iacute;a y la ausencia en dicha comunidad de parasitosis por helmintos q ue se transmiten con el consumo de carne suina. Se analizaron cuestiones relacionadas con las costumbres alimenticias de la comunidad religiosa (su filosof&amp;iacute;a, sus libros sagrados), utiliz&amp;aacute;ndose lo s conocimientos de Zoolog &amp;iacute;a y Parasitolog&amp;iacute;a para dar fundamento cient&amp;iacute;fico al v&amp;iacute;nculo se&amp;ntilde;alado. Con esto se reconocieron diferencias entre preceptos religiosos y construcciones cient&amp;iacute;fica s, as&amp;iacute; como los fundamentos sanitarios de la adecuada tecnolog&amp;iacute;a en la cr&amp;iacute;a del cerdo. La experiencia educativa realizada confirma que el tratamiento de temas disciplinares bajo un enfoque CTS es una forma de integrar el conoc imiento, promover la interacci&amp;oacute;n e intercambio disciplinar y humanizar la cien cia. El enfoque apunta a la confluencia de propuestas que promueven la participaci&amp;oacute;n de los ciudadanos en los problemas sociales y ambientales. Busca el desarrollo de capacidades y de motivaci&amp;oacute;n q ue permitan a la persona una participaci&amp;oacute;n responsable y cr&amp;iacute;tica en las decisiones que orientan el desarrollo de la ciencia y la tecnolog&amp;iacute;a.</text>
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                <text>CIECIBA 2017 : II Congreso Internacional de Ense&amp;ntilde;anza de las Ciencias B&amp;aacute;sicas / Compiladores Laura Dom&amp;iacute;nguez, Walter Larrosa. 7-9 setiembre, 2017 Udelar, 2017&amp;nbsp; p. 78-89</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt; Chemical Basis of the resistance of Barley seeds to pathogenic fungi.&lt;/strong&gt;</text>
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                <text>HORDEUM VULGARE</text>
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                <text>ALQUILRESORCINOLES</text>
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                <text>HONGOS PATOGENOS</text>
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                <text>The 5-(n)-alkylresorcinol fraction of the epicuticular waxes of Hordeum vulgare seeds appeared to be responsible for their in-born resistance to pathogenic fungi such as Aspergillus niger and Penicillium crysogenum. The antifungal properties of this fraction were evaluated qualitatively and quantitatively with a novel bioassay where the extreme lipophilicity of these compounds was taken into account. The minimum inhibitory concentration in the fungi tested ranged from 5.6 to 10 micrograms cm-2 for the alkyresorcinols. The behaviour of the different cultivars against these fungi could be predicted by measuring the natural amount of resorcinols of each variety by TLC-scanning densitometry. The ranking of cultivars thus established correlated well with the field behaviour of each cultivar, providing a useful and rapid method for predicting the behaviour against fungi of new varieties being developed.</text>
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                <text>&lt;strong&gt;Garc&amp;iacute;a, C&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Garc&amp;iacute;a, S&lt;/strong&gt;</text>
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                <text>Phytochemistry v. 44, no. 3, 1997. -- p. 415-418</text>
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                <text>Elsevier</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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      </tag>
      <tag tagId="987">
        <name>Resistencia</name>
      </tag>
      <tag tagId="15">
        <name>Uruguay</name>
      </tag>
    </tagContainer>
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</itemContainer>
