14 25 6754 https://riquim.fq.edu.uy/files/original/47af6c2f24e3ba348b99d9b5d2c48d1b.pdf 582ad43322e2f0b6d55fd03d4191b3e1 https://riquim.fq.edu.uy/files/original/ef6aa6112add89617bd51488a36547f3.png 4e9bc12ad78426af8352924a32498ef3 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Height 155 Width 182 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Solid phase labelling of technetium-99m glutamic acid : radiopharmacological studies</strong></p> Subject The topic of the resource ACIDO GLUTAMICO TECNECIO RADIOFARMACOLOGIA BIBLIOGRAFIA NACIONAL QUIMICA 1989 Abstract A summary of the resource. <p><span class="e"><span class="abstract">Amino acids labelled with ¹¹C and ¹³N are used in localizing tumours, and in scintiscanning pancreas and myocardium. The behaviour of glutamic acid labelled with ^99mTc in healthy and tumour bearing animals is described. Under optimal conditions, a labelling efficiency of 26% is obtained, with a radiochemical purity of 96% and no detectable colloids. Zinc concentrations in the final preparation are well below those at which chemical toxicity becomes apparent. Previous studies suggest the structure as that of an oxotechnetium complex (TcO₂(glu₂))^4- (pH 6). Biodistribution studies have been performed in normal mice. Paper electrophoresis shows that the complex is excreted unchanged via the kidneys. In animals with adenocarcinoma at various stages of differentiation, tumour to blood ratios of between 0.4 and 2.0 are observed. Blood clearance and renal excretion in human subjects are reported and uptake in human breast carcinoma is demonstrated</span></span></p> Creator An entity primarily responsible for making the resource <strong>Campos, E.</strong> <a title="Curriculum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6f16399c452f7b13f8a01a148cb38e12" target="_blank"><strong>Kremer, Carlos</strong></a> <strong>Le&oacute;n, A.</strong> <strong>Mart&iacute;nez, G.</strong> <strong>Gaudiano, J.</strong> Source A related resource from which the described resource is derived Medicina Nuclearis v. 1, no. Heft 1, 1989. -- p. 5-10 Rights Information about rights held in and over the resource <p class="western" lang="es-ES" align="left"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p class="western" lang="es-ES">(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p class="western" lang="es-ES"><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p class="western" lang="es-ES">(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p class="western" style="margin-bottom: 0cm;" lang="es-ES"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context <span class="e"><span class="cc journal">ISSN 0863-1271</span></span> 1989 Acido glutamico Bibliografía Nacional Química Radiofarmacologia Tecnecio https://riquim.fq.edu.uy/files/original/86443ac75378ca09f34e26be3b06690c.pdf 0d5abf819c634a05a1b80216e7d08c44 https://riquim.fq.edu.uy/files/original/42537f44093f9694accc4ba73d1050f0.jpg a503ddd326ff0b1d34a7e384c6a62448 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Solid-phase reduction of 99mTcO4- with zinc : a method for the preparation of difficult technetium-99m complexes</strong></p> Subject The topic of the resource AMINOACIDOS AMINAS TECNECIO BIBLIOGRAFIA NACIONAL QUIMICA 1989 Abstract A summary of the resource. <p>Two groups of compounds: aminoacids (glutamic acid, glutamine, glycine, lysine) and amines (ethylenediamine, diethylenetriamine, o&ndash;phenantroline, o&ndash;phenylenediamine) have been labelled with 99mTc by means of a solid phase reduction using fine powdered zinc as reducing agent. In all cases radiochemical purity in excess of 90% was obtained, with no evidence of colloid formation. Labelling yields were variable depending on the ligand used. The results show that the method presented allows to label with 99mTc some molecules for which the use of conventional techniques is not feasible.</p> Creator An entity primarily responsible for making the resource <a title="Curriculum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6f16399c452f7b13f8a01a148cb38e12" target="_blank"><strong>Kremer, Carlos</strong></a> <strong>Le&oacute;n, A.</strong> <a title="Curriculum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a> <strong>Cartesio, S.</strong> <strong>Ures, C.</strong> <a title="Curriculum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1023bf078c82efde0baa86eb3a1163e6" target="_blank"><strong>Savio, Eduardo</strong></a> <strong>Campos de Kremer, Estrella</strong> <a title="Curriculum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=37cace18c8d1da50d33d6bd4f8f1a607" target="_blank"><strong>Kremer, Eduardo</strong></a> Source A related resource from which the described resource is derived Journal of Labelled Compounds and Radiopharmaceuticals&nbsp; v. 27, no. 11, 1989. -- p. 1331-1340 Publisher An entity responsible for making the resource available Willey Date A point or period of time associated with an event in the lifecycle of the resource 1989 Rights Information about rights held in and over the resource <p class="western" lang="es-ES" align="left"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p class="western" lang="es-ES">(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p class="western" lang="es-ES"><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p class="western" lang="es-ES">(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p class="western" style="margin-bottom: 0cm;" lang="es-ES"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context 10.1002/jlcr.2580271115 Aminas Aminoácidos Bibliografía Nacional Química Tecnecio https://riquim.fq.edu.uy/files/original/aa8f10a8762dbdee2cacc2a5cacdd2c2.pdf dd609a14dec0e2c26197f2f6ec8e9093 https://riquim.fq.edu.uy/files/original/5a72d44c1cd6fd480756302fa92f2134.jpg 9431e49f92a7390b0a62bcac1de27ae1 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 227 Width 155 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Soluci&oacute;n tope universal a fuerza i&oacute;nica constante seg&uacute;n Britton y Robinson</strong></p> Subject The topic of the resource CROMATOGRAFIA ELECTROFORESIS ALCALOIDES 1962 BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA Creator An entity primarily responsible for making the resource <strong>Coch Frugoni, J. A.</strong> Source A related resource from which the described resource is derived COR : Comunicaciones Originales Cortas y Res&uacute;menes v. 1, n&ordm; 2, 1962. -- p. 142 com. 111 Publisher An entity responsible for making the resource available Asociaci&oacute;n de Estudiantes de Qu&iacute;mica (Uruguay) Date A point or period of time associated with an event in the lifecycle of the resource 1962 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel PDF Language A language of the resource Espa&ntilde;ol Type The nature or genre of the resource Art&iacute;culo 1962 Alcaloides Bibliografía Nacional Química Cromatografía Electrofóresis https://riquim.fq.edu.uy/files/original/035760ea01cc876545b8116e6bbbe088.pdf 2602fbe6cb3d864a8bbbe24afc96f381 https://riquim.fq.edu.uy/files/original/2c5d1b60a3a4ebf73ec68e3082d36e20.jpg c11b5707bc79d7f43df96f67e4da72fb Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 5 Channels 3 Height 48 Width 208 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Some new esters of chromone 2-carboxylic acid</strong></p> Subject The topic of the resource QU&Iacute;MICA ORG&Aacute;NICA ESTERES &Aacute;CIDOS CARBOXILICOS BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA 1961 Abstract A summary of the resource. <p>With the view of further pharmacological work by one of us (K. V.-B.), it was decided to synthesize certain esters of chromone-2-carboxylic acid, not previously described1&ndash;4. The following compounds were obtained : dimethylaminoethyl-chromone-2-carboxylate hydrochloride (Ia), the methiodide of the base (Ib); tropyl-chromone-2-carboxylate (IIa), its</p> Creator An entity primarily responsible for making the resource <strong>De Vries, Juan X.</strong> <strong>Vidal Beretervide, Kempis</strong> Source A related resource from which the described resource is derived Nature v. 191, 1961. -- p. 171 Publisher An entity responsible for making the resource available Nature Date A point or period of time associated with an event in the lifecycle of the resource 1961 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context doi:10.1038/191171a0 https://riquim.fq.edu.uy/files/original/f501d836d71f08b1a3f70036431a012c.pdf 887368cdcfd41924a3752d0133b638f1 https://riquim.fq.edu.uy/files/original/4b277cc00a58905687af17420a13b0a3.gif 70591ccee05c77712c9b8ff4eb9b9273 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 7 Channels 3 Height 219 Width 168 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Structure of syn-1-tert-butyl-4-(4-tert-butylcyclohexylidene)cyclohexane</strong></p> Subject The topic of the resource BUTILCICLOHEXANO BIBLIOGRAFIA NACIONAL QUIMICA 1988 CRISTALOGRAFIA Abstract A summary of the resource. C20H36 , Mr=276"3, triclinic, Pi, a= 6.212 (3), b= 11.39 (4), c= 15.17 (3) A, a= 117.5 (8), fl= 72.56 (2), y= 102-2 (6) &deg;, V= 905(8)A 3, z=2, Dx= 1.23Mgm -3, MoKa, 2= 0.71069 A, g=0.276mm -~, F(000)= 312, T= 294K, R=0.044 for 1534 reflections. The two cyclohexane rings adopt differently distorted chair conformations. All bond distances and angles within the molecule are normal. The crystal packing is mainly stabilized by van der Waals forces. Creator An entity primarily responsible for making the resource <strong>Mariezcurrena, R.</strong> <a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=7b9bf747fb311cff42d0d079ef90c05f" target="_blank"><strong>Fornaro, Laura</strong></a> Source A related resource from which the described resource is derived Acta Crystallographica C v. C 44, no.12, 1988. -- p. 2189-2191 Publisher An entity responsible for making the resource available IUCR Date A point or period of time associated with an event in the lifecycle of the resource 1988 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context DOI: 10.1107/S0108270188008030 Butilciclohexano Cristalografía https://riquim.fq.edu.uy/files/original/89736c07b52be1bd547a5f6dff27f240.pdf ed9af99e69a8f1288d1d0f1f9ac77566 https://riquim.fq.edu.uy/files/original/615ca85116763bf3708c3831c3053a90.jpg a2fd55751f2a2239ce122bb4fd926c80 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 3510 Width 2548 https://riquim.fq.edu.uy/files/original/64cc35c4146c265a9fa3bccc265fab43.PDF 422d243156d4098a3744c6c221f0e308 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Tesis de doctorado, maestría, trabajos de diploma y monografías técnicas Description An account of the resource Versiones electrónicas de las tesis de doctorado, maestría y trabajos de diploma de la Facultad de Química, Universidad de la República (UdelaR). Incluye únicamente trabajos hasta el año 2023. Los trabajos posteriores se encuentran disponibles en el Repositorio Colibrí. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Study of the movement of the WPD flexible loop of human protein tyrosine phosphatase PTP1B and the factors that influence it</strong></p> Subject The topic of the resource QU&Iacute;MICA COMPUTACIONAL CRISTALOGRAF&Iacute;A PTP1B LAZO WPD TESIS TESIS DE DOCTORADO URUGUAY Abstract A summary of the resource. El presente trabajo de tesis se enmarca dentro del estudio de la estructura de diferentes complejos entre una prote&iacute;na de inter&eacute;s farmacol&oacute;gico y ligandos, y el an&aacute;lisis de las consecuencias que dichos modelos estructurales tienen sobre los mecanismos tanto de inhibici&oacute;n como catal&iacute;tico. En particular, este trabajo apunta hacia el refinamiento a resoluci&oacute;n mediana de la enzima humana PTP1B y, m&aacute;s espec&iacute;ficamente, al estudio estructural por cristalograf&iacute;a y modelizaci&oacute;n del movimiento del lazo flexible WPD de esta enzima frente a la presencia de diferentes iones hal&oacute;genos. La prote&iacute;na de inter&eacute;s fue co-cristalizada en diferentes concentraciones de buffer acetato y de iones hal&oacute;geno (Br &ndash; y I -). Estos cristales fueron medidos en fuentes de radiaci&oacute;n sincrotr&oacute;nica, y las estructuras tridimensionales de los complejos fueron determinadas. Estos datos experimentales permitieron comprobar que en los complejos formados por la prote&iacute;na y el ion bromuro el lazo WPD fue encontrado tanto en la conformaci&oacute;n cerrada como la abierta, mientras que en los complejos con el ion ioduro s&oacute;lo se obtuvieron estructuras en las que el mencionado lazo se encontraba en conformaci&oacute;n cerrada. Esto estar&iacute;a indicando una relaci&oacute;n entre la identidad del ion presente en el complejo y la fuerza de las interacciones establecidas entre &eacute;ste y los residuos proteicos circundantes. Los estudios cristalogr&aacute;ficos tambi&eacute;n permitieron determinar una correlaci&oacute;n entre la concentraci&oacute;n de haluro presente en la mezcla en la que el cristal fue crecido y laconformaci&oacute;n del lazo en estudio en dicho cristal. A mayor concentraci&oacute;n del haluro, mayor es la ocupaci&oacute;n tanto del ion como de la conformaci&oacute;n cerrada del lazo. Con respecto a esto, se observ&oacute; que cuando la soluci&oacute;n presentaba concentraciones elevadas tanto de acetato como del haluro, el efecto del primero prevalec&iacute;a, y la ocupaci&oacute;n del haluro disminu&iacute;a. En busca de una correlaci&oacute;n entre el tipo de ion presente en el complejo y la ocupaci&oacute;n relativa de cada uno de los iones presentes, se llev&oacute; a cabo una serie de estudios te&oacute;ricos, empleando diferentes t&eacute;cnicas y niveles de teor&iacute;a. Los movimientos colectivos de la enzima PTP1B en complejo con los dos haluros considerados fueron estudiados a trav&eacute;s de una simulaci&oacute;n de Din&aacute;mica Molecular, mpleando el m&oacute;dulo SANDER del programa AMBER10. La informaci&oacute;n obtenida respecto al movimiento del mencionado lazo en ambos complejos fue consistente con las observaciones experimentales obtenidas en este mismo trabajo: mientras que el complejo prote&iacute;na-bromuro presenta un cambio conformacional a lo largo de la simulaci&oacute;n, esto no se observ&oacute; para el complejo prote&iacute;na-ioduro. Esto apoya la teor&iacute;a previamente planteada de la existencia de interacciones diferenciadas entre los dos haluros y los residuos circundantes. Para lograr una mejor comprensi&oacute;n de las interacciones actuantes entre ambos iones y los residuos proteicos de la regi&oacute;n catal&iacute;tica, se est&aacute;n llevando a cabo optimizaciones de geometr&iacute;a para cuatro de los complejos (PTP1B-bromuro con el lazo en conformaci&oacute;n cerrada, el mismo complejo con el lazo en la conformaci&oacute;n abierta, PTP1B-ioduro en conformaci&oacute;n abierta y el mismo complejo en conformaci&oacute;n cerrada). Estos c&aacute;lculos se est&aacute;n llevando a cabo empleando el modelo multicapa ONIOM del programa Gaussian09, el cual nos permite estudiar las partes m&aacute;s relevantes de la estructura a un nivel de funcionales de la densidad, empleando el funcional M06, y empleando la base DGDZV para representar los orbitales de Kohn-Sham de ambos iones, y la base 6-31G* para representar los residuos proteicos del sitio catal&iacute;tico. El resto de la prote&iacute;na se est&aacute; estudiando a nivel de Mec&aacute;nica Molecular, empleando el campo de fuerza AMBER para representar las interacciones existentes. Una etapa cr&iacute;tica para poder emplear m&eacute;todos h&iacute;bridos es la correcta determinaci&oacute;n de la regi&oacute;n a estudiar al nivel m&aacute;s elevado de teor&iacute;a (DFT). En este trabajo se presenta la metodolog&iacute;a empleada para lograrlo, y se deja constancia de los residuos que se consideran dentro de la regi&oacute;n m&aacute;s relevante de la estructura. El presente trabajo muestra que ciertas interacciones entre los residuos del sitio catal&iacute;tico y el ligando presente en el complejo ser&iacute;an los responsables de la conformaci&oacute;n adoptada por el lazo flexible WPD de la prote&iacute;na PTP1B. Una vez se terminen los estudios h&iacute;bridos y se logre determinar cu&aacute;les son los principales residuos catal&iacute;ticos, se tendr&aacute; un punto de partida confiable para el dise&ntilde;o costo-efectivo de posibles inhibidores espec&iacute;ficos para esta enzima. Creator An entity primarily responsible for making the resource <strong>Katz Wisel, Aline</strong> Publisher An entity responsible for making the resource available Facultad de Qu&iacute;mica UdelaR Date A point or period of time associated with an event in the lifecycle of the resource 2011 Contributor An entity responsible for making contributions to the resource <strong>Dr.Podjarny, Alberto D. (Director de Tesis)</strong> <strong>Dr.Ventura, Oscar N. (Director de Tesis)</strong> Rights Information about rights held in and over the resource <p><em><strong>Informaci&oacute;n sobre Derechos de Autor</strong> </em></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><span style="text-decoration: underline;"><strong> La legislaci&oacute;n uruguaya</strong> </span>protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel Pdf Extent The size or duration of the resource. 205 p. Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Tesis Identifier An unambiguous reference to the resource within a given context TD 54:681.3 KAT Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Uruguay Química computacional https://riquim.fq.edu.uy/files/original/229a5ce48823dfd7362454e34e0e96ce.pdf 0d5abf819c634a05a1b80216e7d08c44 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Suggestions for the Modification of Assessment Procedures in Analytical Chemistry Courses : The Statistical Approach</strong></p> Subject The topic of the resource CURSOS DE QUIMICA ANALITICA EVALUACION ESTADISTICA BIBLIOGRAFIA NACIONAL QUIMICA 1989 Abstract A summary of the resource. <p>Determines by means of statistical techniques whether samples of unknown composition provided to students for identification as part of a test of practical ability and theoretical comprehension present significant differences in their degree of difficulty.</p> Creator An entity primarily responsible for making the resource <strong>Mart&iacute;nez Luaces, V&iacute;ctor</strong> <strong>Labandera Gaggero, F.</strong> Source A related resource from which the described resource is derived Journal of Chemical Education&nbsp; v. 66, no. 10, 1989. -- p. 843-844 Rights Information about rights held in and over the resource <p class="western" lang="es-ES" align="left"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p class="western" lang="es-ES">(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p class="western" lang="es-ES"><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p class="western" lang="es-ES">(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p class="western" style="margin-bottom: 0cm;" lang="es-ES"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context ISSN: 0021-9584 1989 Bibliografía Nacional Química Curos de química analítica Evaluación estadística https://riquim.fq.edu.uy/files/original/bf9e56881a8b0fbf6bcb1a6053700df6.pdf fc73269198cebd6e2c563584f4e84a69 https://riquim.fq.edu.uy/files/original/1e6eb911ed024e77811c56a3b5a1457d.jpg 0e50764e06700482aa22d660b7da2cc6 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 238 Width 160 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Sur la nature de l'action inhibitrice "in vitro" de l'antivirus diphterique</strong></p> Subject The topic of the resource INMUNOLOG&Iacute;A ANTIINFECCIOSOS 1938 BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA DIFTERIA Creator An entity primarily responsible for making the resource <strong>Diaz Romero, C.</strong> Source A related resource from which the described resource is derived Archivos de la Sociedad de Biolog&iacute;a de Montevideo v. 9, no. 1, 1938. -- p 48-54 Publisher An entity responsible for making the resource available Sociedad de Biolog&iacute;a de Montevideo Date A point or period of time associated with an event in the lifecycle of the resource 1938 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel PDF Language A language of the resource Espa&ntilde;ol Type The nature or genre of the resource Art&iacute;culo Antivirus Inmunología https://riquim.fq.edu.uy/files/original/3ff983c98f9c825fcaf4b17a97f6068d.pdf 47a04f8f934ca1a865868e503e4e507f https://riquim.fq.edu.uy/files/original/360eb465bbe02fad32a4083206bd3c1f.jpg 54ac723e66a5c819c57c68f1d00f8598 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 201 Width 155 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data Papel Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Synthese von Benzyltetrahydroisochinolinen durch phenolische cyclisicrung</strong></p> Subject The topic of the resource QU&Iacute;MICA ANAL&Iacute;TICA QU&Iacute;MICA ORG&Aacute;NICA S&iacute;NTESIS ORG&Aacute;NICA FENOLES BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA 1973 Creator An entity primarily responsible for making the resource <strong>Falco, M. R.</strong> <strong>De Vries, J. X.</strong> <strong>Mann, G.</strong> Source A related resource from which the described resource is derived Zeitschrift f&uuml;r Chemie v. 13, no. 2, 1973. -- p. 56 <br /><br /> Publisher An entity responsible for making the resource available Wiley Date A point or period of time associated with an event in the lifecycle of the resource 1973 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Language A language of the resource Alem&aacute;n Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context DOI: 10.1002/zfch.19730130204<br /><br /> Fenoles Química analítica Química orgánica Síntesis orgánica https://riquim.fq.edu.uy/files/original/ca864dc1ca2902235fa620c194e54af6.pdf 00856400ed20b3ff9ad90ff1d68f3dcc https://riquim.fq.edu.uy/files/original/7b284667d5c4eb51e2a3ec51bb925e06.gif 028acae679e19f761c10f9fc39a1d7e0 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 150 Width 112 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity</strong></p> Subject The topic of the resource ANTIPARASITARIOS MICROCYSTIS AERUGINOSA ANTIPALUDICO BIBLIOGRAFIA NACIONAL QUIMICA 2012 Abstract A summary of the resource. <p>Marine natural products1 play an important role in drug development particularly in anticancer, antibiotics and antiparasitics drugs.2 Various bioactive cyanobacterial compounds exhibit unique structural features like cyclic peptides containing azole heterocycles. 3 It is well known that macrocyclic peptides can demonstrate drug-like physicochemical and pharmacokinetic properties such as good metabolic stability, solubility, lipophilicity and bioavailability.4 In addition, asymmetrical cyclopeptides are considered as new scaffolds for supramolecular chemistry and provides an important method for the development and preparation of nanoscale objects.5 Examples of azole cyclopeptides are aerucyclamide B (1),6 dendroamide A (2),7 and venturamide A (3),8 Figure 1. Aerucyclamide B was isolated in 2008 by Gademann and co-workers from the toxic freshwater cyanobacterium Microcystis aeruginosa PCC 7806 and displays potent and selective antiplasmodial activity against Plasmodium falciparum K1. This species is the most virulent of the genus Plasmodium and causes more than 95% of malaria-related morbidity and mortality. According to the World Health Organization 2011 report, there were an estimated 216 million episodes and 655000 deaths of malaria in 2010.9 Various antimalarial drugs are presently used for the treatment of this tropical disease, but the rapid spread of resistance seriously compromises their efficacy.10</p> Creator An entity primarily responsible for making the resource <strong>Pe&ntilde;a, Stella</strong> <strong>Scarone, Laura</strong> <a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=4be67895997a04bff5e21d32915751e0" target="_blank"><strong>Manta, Eduardo</strong></a> <strong>Stewart, Lindsay</strong> <strong>Yardley, Vanessa</strong> <strong>Croft, Simon</strong> <a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1c6ad9332d8217df75da8d2b87aeb826" target="_blank"><strong>Serra, Gloria</strong></a> Source A related resource from which the described resource is derived Bioorganic and Medicinal Chemistry Letters v. 22, no. 15, 2012. -- p. 4994-4997 Publisher An entity responsible for making the resource available Elsevier Date A point or period of time associated with an event in the lifecycle of the resource 2012 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context http://dx.doi.org/10.1016/j.bmcl.2012.06.028 Antipaludico Antiparasitarios Mycrocystis Aeruginosa https://riquim.fq.edu.uy/files/original/0b45e6755c6fb04a482e49e5edfd4184.pdf e178036d9674f251826713e8851bbff2 https://riquim.fq.edu.uy/files/original/d051331d0db12cb33bb88f0d36cec250.jpg 789e8d1f4801bfe6aeb73059cc114716 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 163 Width 110 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Synthesis spectroscopic characterization and crystal structure of disulfamethoxazole diaquo Ni(II) monohydrate.</strong></p> Subject The topic of the resource SINTESIS ESPECTROSCOPIA DISULFAMETOXAZOL BIBLIOGRAFIA NACIONAL QUIMICA 2005 Abstract A summary of the resource. The novel disulfamethoxazole diaquo Ni(II) monohydrate, [Ni(sulfamethoxazole)2(H2O)2] � H2O, was synthesized, characterized by infrared and electronic spectroscopies and the crystal structure determined. The compound crystallized in the monoclinic centrosymmetric space group P21/c, with four asymmetric units per unit cell. The nickel atoms are in slightly distorted regular octahedra, coordinated by four nitrogen atoms, two from N-arylamine and two from N-sulfonamide with the apical positions occupied by two oxygen atoms from the water molecules. Creator An entity primarily responsible for making the resource <a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042"><strong>Torre, Mar&iacute;a H</strong></a> <strong>Calvo, S</strong> <a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=330eeda61de9937431a7182c44a5ee24"><strong>Pardo, Helena</strong></a> <a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=31ed37f6d0196c1ca18c1b4dfab6de76"><strong>Mombr&uacute; Rodr&iacute;guez, Alvaro Washington</strong></a> Source A related resource from which the described resource is derived Journal of Coordination Chemistry v. 58, no. 6, 2005. -- p. 513-520 Publisher An entity responsible for making the resource available Taylor &amp; Francis Date A point or period of time associated with an event in the lifecycle of the resource 2005 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context DOI: 10.1080/00958970500037516 Disulfametoxazol Espectroscopía Síntesis https://riquim.fq.edu.uy/files/original/3e6bfae65f48e3b13c0ab34b89a5cb98.pdf 099d8a24181273607f24e3f7a5356565 https://riquim.fq.edu.uy/files/original/d39489153f2fb48f967ee2c28818d2e9.jpg 38fb13edece881572e51dce797266344 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 155 Width 116 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Systematic process evaluation of the conjugation of proteins to gold nanoparticles</strong></p> Subject The topic of the resource NANOTECNOLOGIA BIOCONJUGACION NANOPARTICULAS PROTEINAS ESTABILIDAD COLOIDAL BIBLIOGRAFIA NACIONAL QUIMICA 2021 Abstract A summary of the resource. <p>The present work addresses some fundamental aspects in the preparation of protein-conjugated gold nanoparticles, in order to ensure an appropriate final product. Ten broadly available and/or easy to implement analytical tools were benchmarked and compared in their capacity to provide reliable and conclusive information for each step of the procedure. These techniques included transmission electron microscopy, UV/VIS spectroscopy, dynamic light scattering, zeta-potential, Fourier-transformed infrared spectroscopy, colloidal stability<br />titration, end-point colloidal stability analysis, cyclic voltammetry, agarose gel electrophoresis and size-exclusion<br />chromatography (SEC). Four different proteins widely used as adaptors or blocking agents were tested, together with 13 nm gold nanoparticles containing different surface chemistries. Among all tested techniques, some of the least popular among nanomaterial scientists probed to be the most informative, including colloidal stability, gel electrophoresis and SEC; the latter being also an efficient purification procedure. These three techniques provide low-cost, low time consuming, sensitive and robust ways to assess the success of the nanoparticle bioconjugation steps, especially when used in adequate combinations.</p> Creator An entity primarily responsible for making the resource <strong>Fag&uacute;ndez, Pablo</strong> <strong>Botasini, Santiago</strong> <strong>Tosar, Juan Pablo</strong> <strong>M&eacute;ndez, Eduardo</strong> Source A related resource from which the described resource is derived Heliyon&nbsp;v. 7, 2021. -- e07392 Publisher An entity responsible for making the resource available Elsevier Date A point or period of time associated with an event in the lifecycle of the resource 2021 Rights Information about rights held in and over the resource <p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p> <p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho&nbsp;de autor</strong><span>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p> <span id="docs-internal-guid-c585b616-7fff-4f2d-709c-1a82e930f7c3"><strong>ADVERTENCIA:</strong><span>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span></span> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context <span id="docs-internal-guid-07b5facf-7fff-900a-31c6-7fbe55d6c3c5"><span>10.1016/j.heliyon.2021.e07392 </span></span> Bioconjugación Estabilidad coloidal Nanopartículas Nanotecnología Proteínas https://riquim.fq.edu.uy/files/original/4675c6338fb2986a1788c859c973b604.pdf 80888825b7a330a0dd9ffd1d4a860b6d https://riquim.fq.edu.uy/files/original/a074882e86cbf8182c9432059c8a7ac8.jpg 766ede8a79c33f24b93cb484556e19ba Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 198 Width 157 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>T&iacute;tulo y avidez de anticuerpos antigliadina en enfermos cel&iacute;acos (Ec)</strong></p> Subject The topic of the resource ANTICUERPOS ENFERMEDAD CEL&Iacute;ACA ANTICUERPOS ANTIGLIADINA ENFERMEDADES AUTOINMUNES BIBLIOGRAFIA NACIONAL QUIMICA 1989 Abstract A summary of the resource. <img 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alt="" /> Creator An entity primarily responsible for making the resource <strong>Molina, M.C.</strong> <a title="Curriculum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8b2cacb0aafc512133624fa7b9bf174c" target="_blank"><strong>Salinas, G.</strong></a> <a title="Curriculum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=9d36a9655c915bddd80b664491d73ec8" target="_blank"><strong>Nieto, Alberto</strong></a> Source A related resource from which the described resource is derived Inmunolog&iacute;a&nbsp; v. 8, no. 3, 1989. -- p. 102-106 Rights Information about rights held in and over the resource <p class="western" lang="es-ES" align="left"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p class="western" lang="es-ES">(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p class="western" lang="es-ES"><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p class="western" lang="es-ES">(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p class="western" style="margin-bottom: 0cm;" lang="es-ES"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Espa&ntilde;ol Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context ISSN (digital) 0213-0626 1989 Anticuerpos Anticuerpos antigliadina Bibliografía Nacional Química Enfermedad celíaca Enfermedades autoinmunes https://riquim.fq.edu.uy/files/original/168f1ac2e3d7d98ff03dbd7a04d26167.jpg 9f028d5805b4873f1ee6fc1f14683245 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 200 Width 155 https://riquim.fq.edu.uy/files/original/e80199b96e588ad7fc532c0763dbb1a6.pdf 00856400ed20b3ff9ad90ff1d68f3dcc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The cis-trans energy difference in Bi-1-Cyclopropen-1-yl and related compounds</strong></p> Subject The topic of the resource QUIMICA CUANTICA ISOMEROS GEOMETRICOS ISOMEROS CIS ISOMEROS TRANS BIBLIOGRAFIA NACIONAL QUIMICA 1980 Abstract A summary of the resource. The cis-trans energy difference of bi-1-cyclopropen-1-yl and the fluoro-substituted derivs. are studied by ab initio methods in order to establish the stability of the cis and trans diene isomers. The results of the ab initio method STO-3G points toward the trans bi-1-cyclopropen-1-yl as the most stable isomer (0.2 kcal/mol). The energy of the transition state is about 2.5 kcal/mol above that of the trans isomer. The electronic transitions of the isomers are also reported Creator An entity primarily responsible for making the resource <strong>Sosa, R.M.</strong> <a title="Curr&iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=40f23b501897bd535c01b6602f1ea346" target="_blank"><strong>Ventura , O.N.</strong></a> Source A related resource from which the described resource is derived Theoretica Chimica Acta v. 56, no. 2, 1980.-- p. 157-162 Publisher An entity responsible for making the resource available Springer Date A point or period of time associated with an event in the lifecycle of the resource 1980 Rights Information about rights held in and over the resource <p align="LEFT"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p style="margin-bottom: 0cm;"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context ISSN:0040-5744 Isómeros geométricos Química cuántica https://riquim.fq.edu.uy/files/original/37164cb5a4b61e3559182271add6a4ce.pdf 00856400ed20b3ff9ad90ff1d68f3dcc https://riquim.fq.edu.uy/files/original/390d77b8356f993b18ecd00bb9b253b2.gif 9fca20c647df4ff8bb67c9cab2d3a164 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 129 Width 100 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The Contribution of oxazolidinone frame to The biological activity of pharmaceutical drugs and natural products</strong></p> Subject The topic of the resource ANTIINFECCIOSOS PRODUCTOS NATURALES FARMACOCINETICA BACTERIAS BIBLIOGRAFIA NACIONAL QUIMICA 2007 Abstract A summary of the resource. The development of resistance by the antibiotics in the Gram-positive pathogenic bacteria over the last twenty years and continuing today has created a need for new antibiotic classes, which may be unaffected by existing bacterial resistance. The oxazolidin-2-ones represent not only a new class with a novel mechanism of action, but also satisfy the requirement for overcoming the resistance mechanisms. Both linezolid and eperozolid, the first chemical candidates, arose from the piperazine subclass, with the first one being chosen further development because of its enhanced pharmacokinetic properties. The main attractive traits of the oxazolidinone series has encouraged further work in the area, and the patent literature reveals that extensive chemical investigation is currently being made. The unexpected early resistance development emphasizes the need for further exploration of features of the oxazolidinone to eliminate these deficiencies. Recently, several changes, involving the C5 side chain as well the N-phenyl heterocyclic ring, give promise for such improvement. Oxazolidinone antibacterial agents comprise also ketolides, derivatives of macrolides, such as erythromycin A, with a newly formed carbamate cycle, with a largely unexplored potential. The oxazolidinone nucleus does not appear only in the structures of antimicrobial drugs, but a number of biological activities are connected with frameworks including the oxazolidinone ring. A partial list of these activities comprises enzyme inhibitors, agonists and antagonists, with a particular citation for a new generation of selective monoamino oxidase inhibitors (befloxatone). The oxazolidinone moiety was found in the structure of few biologically active natural products, such as (-)-cytoxazone and streptazolin. Moreover, in some cases the oxazolidinone ring has been chosen for the preparation of isosteric aza analogues of natural compounds (podophyllotoxin, pilocarpine) that can be more easily synthesised and more hardly inactivated. Finally, the participation of oxazolidinone chiral auxiliaries to several syntheses of natural products must be acknowledged. Creator An entity primarily responsible for making the resource <strong>Zappia, Giovanni</strong> <a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=c63a421d8a96930bcc9fb16ef3819110"><strong>Menendez, Pilar</strong></a> <strong>Delle Monache, Giuliano</strong> <strong>Misiti, Domenico</strong> <strong>Nevola, Laura</strong> <strong>Botta, Bruno</strong> Source A related resource from which the described resource is derived Mini Reviews in Medicinal Chemistry&nbsp; v. 7, no. 4, 2007. -- p. 389-409 Publisher An entity responsible for making the resource available Bentham Science Publishers Ltd. Date A point or period of time associated with an event in the lifecycle of the resource 2007 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context ISSN 1389-5575 Antiinfecciosos Productos naturales https://riquim.fq.edu.uy/files/original/c36f7730eee8e46d803a98feeadf234c.pdf e178036d9674f251826713e8851bbff2 https://riquim.fq.edu.uy/files/original/732348d0bc81c956e0344a3460667527.jpg 5dc29bd3c8f2707078023b6edb28d3b8 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 203 Width 153 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The electroreduction of molecular oxygen on preferentially oriented platinum electrodes in acid solution.</strong></p> <p>&nbsp;</p> Subject The topic of the resource OXIGENO PLATINO BIBLIOGRAFIA NACIONAL QUIMICA 1994 Abstract A summary of the resource. The oxygen electroreduction reaction was studied on two different preferentially oriented ((111)-type and (100)-type and on a conventional polycrystalline (PC) platinum rotating disc electrodes in acid solutions at 30 &deg;C. At low overpotentials, Tafel lines of &minus;0.060 V decade&minus;1 were obtained on the three electrodes in oxygen-saturated 1.0m H2SO4 and 1.0m H2SO4 + y m K2SO4 (0 ⩽y ⩽ 1). At high over-potentials the usual Tafel slope of -0.120V decade&minus;1 was observed on both (111)-type and PC platinum electrodes in 1.0m H2SO4, whereas a slope of &minus;0.165V decade&minus;1 was found on (100)-type platinum. In oxygen-saturated 1.0m H2SO4 the surface coverage by O-containing adsorbates on (100)-type platinum was greater than on both (111)-type and PC platinum. Rotating ring-disc electrode data showed that a higher amount of H2O2 was produced on (100)-type platinum than on the other platinum surfaces. The overpotential against current density plots are influenced by the anion concentration depending on the type of preferentially oriented platinum. Creator An entity primarily responsible for making the resource <strong>Zinola, Carlos Fernando</strong> <strong>Castro Luna, A. M</strong> <strong>Triaca, W.E</strong> Source A related resource from which the described resource is derived Journal of applied electrochemistry v. 24 , no. 2, 1994. -- p. 119-125 Publisher An entity responsible for making the resource available Springer Date A point or period of time associated with an event in the lifecycle of the resource 1994 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p> <p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context doi: 10.1007/BF00247782 Oxígeno Platino https://riquim.fq.edu.uy/files/original/8255cb2adee0c1d466116249510a1b63.pdf 0ebebc2e46cd599f97051dd7aefd7031 https://riquim.fq.edu.uy/files/original/f8ec680829c2f0fff9d674f33eff8935.jpg 8fbf3198b2788327bd938c5d9f527292 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 150 Width 113 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data Pdf <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The habitual nature of food purchases at the supermarket: Implications for policy making</strong></p> Subject The topic of the resource ALIMENTOS <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> COMPORTAMIENTO DEL CONSUMIDOR <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> INFORMACION NUTRICIONAL <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> ALIMENTOS ULTRAPROCESADOS <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> BIBLIOGRAFIA NACIONAL QUIMICA <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> 2020 <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Abstract A summary of the resource. Supermarkets have become the most important provider of food products worldwide. However, empirical evidence about how consumers make their food purchase decisions in this environment is still scarce. The present field study aimed to: i) explore how people make their in-store food purchases, and ii) identify the information they search for when making those purchases. Consumers (n = 144) were intercepted when entering the facilities of three supermarkets in two Uruguayan cities. They were asked to wear a mobile eye-tracker while they made their purchases as they normally do. The great majority of the consumers bought at least one food product or beverage (92%) and, on average, examined products from 2.8 sections. In total, they investigated 37 categories within 13 self-service sections, corresponding to 26 categories of ultra-processed products. For 67% of the products, consumers went straight to the product they seemed to be looking for, grabbed it and put it in their shopping basket or cart, without making any comparison among products. A limited information search was observed. On average, consumers spent 22 s examining products within self-service sections and only 6.9 s were elapsed from the moment they grabbed a product until they put it in the shopping cart. These results provide empirical evidence of the habitual nature of supermarket food purchases in a context characterized by wide availability of ultra-processed products. Taken together, the findings suggest that policies and interventions aimed at reducing purchases of ultra-processed products should disrupt habitual decisions at the point of purchase. In this sense, policies targeted at introducing salient changes on food packages hold potential to disrupt food purchases and encourage consumers to establish new and more healthful food purchase habits. <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Creator An entity primarily responsible for making the resource <strong>&nbsp;Mach&iacute;n, <strong>&nbsp;Leandro</strong></strong> <strong>Curutchet, <strong>Mar&iacute;a Rosa </strong></strong> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <strong>Gugliucci, <strong>Vanessa</strong></strong> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <strong>Vitola, <strong>Agustina</strong></strong> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <strong>&nbsp;Otterbring, <strong>Tobias</strong></strong> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <strong>Alcantara, <strong>Marcela de </strong></strong> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <strong>Ares</strong>, <strong>Gast&oacute;n</strong> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Source A related resource from which the described resource is derived Appetite v. 155, 2020.--pp. 1-7.--e104844 <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Publisher An entity responsible for making the resource available Elsevier <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Date A point or period of time associated with an event in the lifecycle of the resource 2020 <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong> (Por favor lea este aviso antes de abrir los documentos u objetos)<strong> La legislaci&oacute;n uruguaya protege el derecho de autor </strong>sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Format The file format, physical medium, or dimensions of the resource Pdf <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Language A language of the resource Ingl&eacute;s <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Type The nature or genre of the resource Art&iacute;culo <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Identifier An unambiguous reference to the resource within a given context https://doi.org/10.1016/j.appet.2020.104844 <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> <div id="sconnect-is-installed" style="display: none;">2.11.0.0</div> Alimentos Alimentos procesados Comportamiento del consumidor Información nutricional https://riquim.fq.edu.uy/files/original/55464bc9a4aa86eadaa08b390b5a23e9.pdf 00856400ed20b3ff9ad90ff1d68f3dcc https://riquim.fq.edu.uy/files/original/ff1ae9a21df2a6b0caa7984109104f3a.jpeg 267d7414344100e9e3ec5ba5d54d2c06 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 207 Width 160 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The Influence of Cardiovascular Physiology on Dose/Pharmacokinetic and Pharmacokinetic/ Pharmacodynamic Relationships</strong></p> Subject The topic of the resource FARMACOCIN&Eacute;TICA BIBLIOGRAFIA NACIONAL QUIMICA 2006 CARDIOLOGIA Abstract A summary of the resource. Inter- and intraindividual variability in the relationship between dose and clinical &ndash; or pharmacodynamic &ndash; response of a drug can be analysed in two steps: firstly, by considering the plasma pharmacokinetic response to a given dose and, secondly, by the connection between both pharmacokinetic and pharmacodynamic responses. As the cardiovascular system is the means of transport of endogenous and exogenous substances, blood flow fraction destined to each organ determines the relative mass of solute in plasma, which is constantly in contact with the tissue. Hence, not only the rate but also the extent of drug transfer would be increased when tissues are irrigated by a higher fraction of cardiac output. Aging and circadian rhythms present similar cardiac output distribution patterns when moving from young to aged adult and from nocturnal to diurnal hours. These two changes lead to an increased blood flow delivery to the extra-splanchnic-renal region in the elderly and in the morning, but with a decreased cardiac output in aged individuals and an increased one during the day. This scenario allows us to forecast substance concentrations outside the blood vessels, which are responsible for the extent of drug elimination and the intensity Creator An entity primarily responsible for making the resource <a href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=caabbc98478c9c9fb71e4b0eb4e4ccd5"><strong>Fagiolino, Pietro</strong></a> <strong>Eiraldi, Rosa</strong> <strong>V&aacute;zquez, Marta</strong> Source A related resource from which the described resource is derived Clinical Pharmacokinetics. v.45, n&ordm; 5, 2006. -- p. 433-448. Publisher An entity responsible for making the resource available Springer Date A point or period of time associated with an event in the lifecycle of the resource 2006 Rights Information about rights held in and over the resource <em><strong>Informaci&oacute;n sobre Derechos de Autor</strong></em><br />(Por favor lea este aviso antes de abrir los documentos u objetos)<br /><em><strong>La legislaci&oacute;n uruguaya</strong></em>&nbsp;protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /><strong>ADVERTENCIA -</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora. Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context DOI: 10.2165/00003088-200645050-00001 Farmacocinética Farmacodinamia Sistema cardiovascular https://riquim.fq.edu.uy/files/original/e32be8a9145de0432dfab4c3d0b68230.pdf 376a431d2e50e65601bb7669aec1843c https://riquim.fq.edu.uy/files/original/8301e56c83653cd98130c9df328e0631.jpg ad0f528a4cfa6702dc9e6641de41b076 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 161 Width 120 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The purple color reaction given by diphenylamine reagent with normal and rheumatic fever sera</strong></p> Subject The topic of the resource DIFENILAMINA COLORIMETR&Iacute;A 1951 BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA Creator An entity primarily responsible for making the resource <strong>Ayala Bonilla, Washington</strong> <strong>Moore, L. V.</strong> <strong>Hess, E.</strong> Source A related resource from which the described resource is derived The Journal of Clinical Investigation. v.30, n&ordm;.7, 1951. -- p. 781-785 Publisher An entity responsible for making the resource available American Society for Clinical Investigation Date A point or period of time associated with an event in the lifecycle of the resource 1951 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo 1951 Bibliografía Nacional Química Colorimetría Difenilamina https://riquim.fq.edu.uy/files/original/4c40f991ce95ae4ed64f7f592cea1ada.pdf d31c90153b0d9029747b24cb4e4bbdd4 https://riquim.fq.edu.uy/files/original/77d7415cc9ff978b8b2299dbf3d486ab.jpg 464c35a3d66445e8251c3a7dc6a2643c Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 155 Width 116 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The role of food packaging on children&rsquo;s diet : insights for the design of comprehensive regulations to encourage healthier eating habits in childhood and beyond</strong></p> Subject The topic of the resource ENVASADO DE ALIMENTOS NI&Ntilde;OS DIETA OBESIDAD INFANTIL ENFERMEDADES NO TRANSMISIBLES POLITICA ALIMENTARIA POLITICAS PUBLICAS BIBLIOGRAFIA NACIONAL QUIMICA 2022 Abstract A summary of the resource. Food packaging design has become a key component of the marketing mix of companies to ensure the long-term success of their products, and to convey information that set apart their products from competitors. The aim of this review is to critically discuss the role of food packaging on children&rsquo;s diet. Food package design plays a key role in attracting children and parents&rsquo; attention, shaping product associations, and influencing their purchase decisions. Packaging elements attracting children&rsquo;s attention and misleading health-related visual and textual cues may encourage children and their parents to choose energy-dense food products with excessive content of sugar, fat, and sodium. Results from this review suggest that comprehensive packaging regulations are necessary to protect children&rsquo;s health and encourage healthier eating habits from early years. Such regulations should go beyond products targeted at children, making informed decisions easier to encourage healthier choices, and including restrictions on the use of health-related cues on all products, as they ultimately influence the diet and the food available in the household. Creator An entity primarily responsible for making the resource <p><strong>Ares, Gast&oacute;n</strong></p> <p><strong>Velazquez, Ana Laura</strong></p> <p><strong>Vidal, Leticia</strong></p> <p><strong>Curutchet, Mar&iacute;a Rosa</strong></p> <p><strong>Varela,&nbsp;Paula</strong></p> Source A related resource from which the described resource is derived Food Quality and Preference, v. 95, 2022. -- e104366 Publisher An entity responsible for making the resource available Elsevier Date A point or period of time associated with an event in the lifecycle of the resource 2022 Rights Information about rights held in and over the resource <p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context <p>https://doi.org/10.1016/j.foodqual.2021.104366</p> Dieta Enfermedades no transmisibles Envasado de alimentos Niños Obesidad infantil Política Alimentaria Políticas Públicas https://riquim.fq.edu.uy/files/original/7ab696cc433717fdd6bfea6820602ee3.pdf f8418a5bef010ccfa56c689eb060f0d4 https://riquim.fq.edu.uy/files/original/59457216b2be30842f9dda0bd5270e8e.jpg e87016c4f107043b9bacbcd8d5cf5db3 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 213 Width 155 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data Papel Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>The separation of the minor alkaloids of Strychnos nux vomica</strong></p> Subject The topic of the resource STRYCHNOS NUX VOMICA ALCALOIDES QU&Iacute;MICA ANAL&Iacute;TICA BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA 1968 Creator An entity primarily responsible for making the resource <strong>Delle Monache, F.</strong> <strong>Gelabert de Brovetto, A.</strong> <strong>Cor, E.</strong> <strong>Marini Bettolo, G. B.</strong> Source A related resource from which the described resource is derived Journal of Chromatography A v. 32, 1968. -- p. 178-179 Publisher An entity responsible for making the resource available Elsevier Date A point or period of time associated with an event in the lifecycle of the resource 1968 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context <p>doi:10.1016/S0021-9673(01)80479-9</p> <p>http://dx.doi.org/10.1016/S0021-9673(01)80479-9<br /><br /></p> Alcaloides Industria Química analítica Strychnos Nux vomica https://riquim.fq.edu.uy/files/original/67b2a20825ee794f5315c79e88bddec8.pdf 0ebebc2e46cd599f97051dd7aefd7031 https://riquim.fq.edu.uy/files/original/dd5b7602c2a2dc98b3c9ae0e5f0f6f04.jpg ac71505de5ba2e574cb5abd1f2ba80a8 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 231 Width 160 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Toxicidad comparada del alcohol y las distintas bebidas alcoh&oacute;licas destiladas nacionales sobre peces mantenidos en acuarios</strong></p> Subject The topic of the resource TOXICOLOG&Iacute;A PECES BEBIDAS ALCOH&Oacute;LICAS URUGUAY 1954 BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA Creator An entity primarily responsible for making the resource <strong>Estable, J.J.<br /></strong> <strong>Grezzi, J. W.</strong> <strong>Varela Rodr&iacute;guez, J.</strong> Source A related resource from which the described resource is derived Archivos de la Sociedad de Biolog&iacute;a de Montevideo v. 21, no. 1-4, 1954. -- p. 43-47 Publisher An entity responsible for making the resource available Sociedad de Biolog&iacute;a de Montevideo Date A point or period of time associated with an event in the lifecycle of the resource 1954 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel PDF Language A language of the resource Espa&ntilde;ol Type The nature or genre of the resource Art&iacute;culo Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Uruguay Animales Bebidas alcohólicas destiladas Peces Toxicología https://riquim.fq.edu.uy/files/original/109bfc46bd8d76354823ce5c85c1634c.pdf 48e99292fac2b4ff6ee84d9d3ef92bf3 https://riquim.fq.edu.uy/files/original/778060e25c4908daaa5919505ccfef02.jpg ac71505de5ba2e574cb5abd1f2ba80a8 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 231 Width 160 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Toxicidad comparada del alcohol y las distintas bebidas destiladas ANCAP en animales de sangre caliente</strong></p> Subject The topic of the resource TOXICOLOG&Iacute;A BEBIDAS ALCOH&Oacute;LICAS URUGUAY 1954 BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA ANCAP Creator An entity primarily responsible for making the resource <strong>Estable, J.J.<br /></strong> <strong>Grezzi, J. W.</strong> Source A related resource from which the described resource is derived Archivos de la Sociedad de Biolog&iacute;a de Montevideo v. 21, no. 1-4, 1954. -- p 47-55 Publisher An entity responsible for making the resource available Sociedad de Biolog&iacute;a de Montevideo Date A point or period of time associated with an event in the lifecycle of the resource 1954 Rights Information about rights held in and over the resource <p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong> sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p> <p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel PDF Language A language of the resource Espa&ntilde;ol Type The nature or genre of the resource Art&iacute;culo Animales de sangre caliente Bebidas alcohólicas destiladas Peces Toxicología https://riquim.fq.edu.uy/files/original/4e4544fbc365562909d2c804e14af9ff.pdf 0ebebc2e46cd599f97051dd7aefd7031 https://riquim.fq.edu.uy/files/original/735fca5000dd76e0933bd73cbcf18697.jpg 16ef83fbc199e789d8359ed6bf0856f9 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 226 Width 155 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Toxicolog&iacute;a e higiene</strong></p> Subject The topic of the resource TOXICOLOG&Iacute;A HIGIENE 1939 BIBLIOGRAF&Iacute;A NACIONAL QU&Iacute;MICA Creator An entity primarily responsible for making the resource <strong>Dotta Viglietti, Clelia</strong> Source A related resource from which the described resource is derived Ph : &Oacute;rgano Oficial de la Asociaci&oacute;n de Estudiantes de Qu&iacute;mica Uruguay v. 11, no. 1, 1939. -- p. 18-23 Publisher An entity responsible for making the resource available Asociaci&oacute;n de Estudiantes de Qu&iacute;mica (Uruguay) Date A point or period of time associated with an event in the lifecycle of the resource 1939 Rights Information about rights held in and over the resource <strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /><br />(Por favor lea este aviso antes de abrir los documentos u objetos)<br /><br /><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /><br />(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /><br /><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora. Format The file format, physical medium, or dimensions of the resource Papel PDF Language A language of the resource Espa&ntilde;ol Type The nature or genre of the resource Art&iacute;culo 1939 Bibliografía Nacional Química Higiene Toxicología https://riquim.fq.edu.uy/files/original/84e1ffb2135bde15af4e12b61ddd67df.PDF 0a962de34c70e298c90d1d5a38b891d7 https://riquim.fq.edu.uy/files/original/319e34bf3dc9fc19ce6afd599ce1c692.pdf 3453ecb63834c87d02aabf87d6007a2e https://riquim.fq.edu.uy/files/original/52f82c7b13231d43d1117cf6fedf8c31.jpg a560589e45b4222f522afb1ca39e3978 Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 842 Width 595 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Tesis de doctorado, maestría, trabajos de diploma y monografías técnicas Description An account of the resource Versiones electrónicas de las tesis de doctorado, maestría y trabajos de diploma de la Facultad de Química, Universidad de la República (UdelaR). Incluye únicamente trabajos hasta el año 2023. Los trabajos posteriores se encuentran disponibles en el Repositorio Colibrí. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <p><strong>Transesterificaci&oacute;n en alcoholes supercr&iacute;ticos como alternativa para la producci&oacute;n de biodiesel</strong></p> Subject The topic of the resource BIODIESEL ALCOHOLES SUPERCR&Iacute;TICOS ETANOL TESIS TESIS DOCTORADO URUGUAY Abstract A summary of the resource. <p>El biodiesel se obtiene tradicionalmente mediante la transesterificaci&oacute;n de un aceite vegetal con un alcohol, generalmente metanol, en presencia de un catalizador qu&iacute;mico b&aacute;sico. Este m&eacute;todo, si bien resulta conveniente por su alta eficiencia y bajo costo, presenta varios inconvenientes, como ser la necesidad de pretratamiento de los materiales grasos muy &aacute;cidos, la imposibilidad de utilizar etanol rectificado (por el contenido de agua presente), la baja calidad de la glicerina producida y la producci&oacute;n de elevados vol&uacute;menes de efluentes. Existen numerosos antecedentes que indican que es posible alcanzar elevadas eficiencias en la s&iacute;ntesis de biodiesel mediante la exposici&oacute;n de aceites a metanol supercr&iacute;tico, sin necesidad de utilizar catalizadores y a&uacute;n en presencia a elevadas concentraciones de agua en el medio de reacci&oacute;n. La posibilidad de disponer de un m&eacute;todo eficiente de transesterificaci&oacute;n en presencia de agua resulta interesante a los efectos de la posible utilizaci&oacute;n de alcohol rectificado, actualmente producido en Uruguay a partir de az&uacute;car de ca&ntilde;a. En esta tesis se estudi&oacute; la eficiencia de la elaboraci&oacute;n de biodiesel en un reactor de flujo continuo a partir de diferentes materiales grasos de origen nacional y mediante la utilizaci&oacute;n de etanol en condiciones supercr&iacute;ticas, determin&aacute;ndose el efecto sobre la eficiencia del proceso de los diferentes par&aacute;metros operativos y, en particular, del nivel de agua adicionado al alcohol. Los resultados obtenidos indican que la elaboraci&oacute;n de biodiesel en alcoholes supercr&iacute;ticos, tanto metanol como etanol, puede ser realizada en forma eficiente si se elige convenientemente los par&aacute;metros operativos del proceso. Se obtuvo contenidos de &eacute;ster m&aacute;ximos en el entorno del 80%, operando un reactor continuo de 42 mL a una temperatura de 350&ordm;C, una presi&oacute;n de 20 MPa y una relaci&oacute;n molar alcohol/aceite de 40:1, para flujos y contenidos de agua variables seg&uacute;n el aceite utilizado. En esas condiciones, el proceso de conversi&oacute;n en biodiesel de los aceites vegetales refinados de soja, girasol y girasol de alto oleico y de ricino, en biodiesel en etanol supercr&iacute;tico se pudo alcanzar en forma relativamente eficiente. Sin embargo, el an&aacute;lisis de los productos de reacci&oacute;n demostr&oacute; que la exposici&oacute;n del material lip&iacute;dico a las condiciones extremas de temperatura y presi&oacute;n requeridas para que ocurra la transesterificaci&oacute;n, produjo la aparici&oacute;n de is&oacute;meros trans de todos los &aacute;cidos grasos insaturados y la reducci&oacute;n del porcentaje de los m&aacute;s insaturados. En general, la adici&oacute;n de agua al alcohol destinado al proceso afect&oacute; favorablemente al rendimiento de la transesterificaci&oacute;n en alcoholes supercr&iacute;ticos, lo que constituy&oacute; una diferencia muy significativa en relaci&oacute;n al proceso conducido mediante la cat&aacute;lisis qu&iacute;mica convencional (el cual requiere del suministro de reactivos anhidros). Este efecto favorable se atribuy&oacute; a la combinaci&oacute;n de dos fen&oacute;menos vinculados con la presencia de agua en el medio de reacci&oacute;n: el aumento de la velocidad de reacci&oacute;n y la disminuci&oacute;n de la degradaci&oacute;n de los &aacute;cidos grasos insaturados. Los trabajos realizados permitieron demostrar que el m&eacute;todo supercr&iacute;tico de transesterificaci&oacute;n sin catalizador constituye una alternativa v&aacute;lida a la cat&aacute;lisis qu&iacute;mica convencional para la s&iacute;ntesis de biodiesel, debiendo considerarse las caracter&iacute;sticas de la materia prima a utilizar para la selecci&oacute;n de los par&aacute;metros operativos &oacute;ptimos. Dado que la mayor&iacute;a de las normativas sobre biodiesel exigen que est&eacute; constituido por no menos de un 96.5% de &eacute;steres alqu&iacute;licos, los trabajos en esta &aacute;rea continuar&aacute;n enfocados a maximizar el contenido de &eacute;ster, lo que &uacute;nicamente se podr&aacute; lograr a costa de disminuir el grado de descomposici&oacute;n.</p> Creator An entity primarily responsible for making the resource <p><strong>Vieitez Osorio, Ignacio</strong></p> Publisher An entity responsible for making the resource available Facultad de Qu&iacute;mica UdelaR Date A point or period of time associated with an event in the lifecycle of the resource 2010 Contributor An entity responsible for making contributions to the resource <strong>Dr. Jachmani&aacute;n Alpuy, Iv&aacute;n ( Director de tesis)</strong> <strong>Dra. Grompone, Mar&iacute;a Antonia (Directora de tesis)</strong> Rights Information about rights held in and over the resource <p>Informaci&oacute;n sobre Derechos de Autor</p> <p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p> <p>La legislaci&oacute;n uruguaya protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource Papel Pdf Extent The size or duration of the resource. 285 p. Language A language of the resource Espa&ntilde;ol Type The nature or genre of the resource Tesis Identifier An unambiguous reference to the resource within a given context TD 665.7 VIE Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Uruguay Alcoholes supercríticos Biiodiesel Etanol