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                <text>&lt;strong&gt;Towards the understanding of the molecular basis for the inhibition of COX-1 and COX-2 by phenolic compounds present in Uruguayan propolis and grape pomace&lt;/strong&gt;</text>
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                <text>&lt;div class="paragraph"&gt;Propolis and grape pomace have significant amounts of phenols which can take part in anti-inflammatory mechanisms. As the cyclooxygenases 1 and 2 (COX-1 and COX-2) are involved in said mechanisms, the possibility for a selective inhibition of COX-2 was analyzed &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in silico&lt;/em&gt;.&lt;/div&gt;&#13;
&lt;div class="paragraph"&gt;Propolis and grape pomace from Uruguayan species were collected, extracted in hydroalcoholic mixture and analyzed. Based on phenols previously identified, and taking as reference the crystallographic structures of COX-1 and COX-2 in complex with the commercial drug Celecoxib, a molecular docking procedure was devised to adjust 123 phenolic molecular models at the enzyme binding sites.&lt;/div&gt;&#13;
&lt;div class="paragraph"&gt;The most important results of this work are that the extracts have an overall inhibition activity very similar in COX-1 and COX-2, i.e. they do not possess selective inhibition activity for COX-2. Nevertheless, 10 compounds of the phenolic database turned out to be more selective and 94 phenols resulted with similar selectivity than Celecoxib, an outcome that accounts for the overall experimental inhibition measures.&lt;/div&gt;&#13;
&lt;div class="paragraph"&gt;Binding site environment observations showed increased polarity in COX-2 as compared with COX-1, suggesting that polarity is the key for selectivity. Accordingly, the screening of molecular contacts pointed to the residues: Arg106, Gln178, Leu338, Ser339, Tyr341, Tyr371, Arg499, Ala502, Val509 and Ser516, which would explain, at the atomic level, the anti-inflammatory effect of the phenolic compounds. Among them, Gln178 and Arg499 appear to be essential for the selective inhibition of COX-2.&lt;/div&gt;</text>
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                <text>&lt;strong&gt;Espinosa, F. Victoria&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Aguilera, Sandra&lt;/strong&gt;</text>
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                <text>Journal of Biomolecular Structure &amp;amp; Dynamics 2015. -- p. 1-66</text>
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                <text>Taylor y Francis Online</text>
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              <elementText elementTextId="458685">
                <text>&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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                <text>DOI:10.1080/07391102.2015.1124808</text>
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                <text>Uruguay</text>
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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Halopeptonella vilamensis gen. nov, sp. nov., a halophilic strictly aerobic bacterium of the family Ectothiorhodospiraceae&lt;/strong&gt;</text>
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                <text>BACTERIAS AEROBICAS</text>
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                <text>HALOPEPTONELLA VILAMENSIS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>A Gram-negative, halophilic, heterotrophic, rod-shaped, non-spore-forming bacterium (SV525T) was isolated from the sediment of a hypersaline lake located at 4600 m above sea level (Laguna Vilama, Argentina). Strain SV525T was strictly aerobic and formed pink-to-magenta colonies. Growth occurred at 10&amp;ndash;35 &amp;deg;C (optimum 25&amp;ndash;30 &amp;deg;C), at pH levels 6.0&amp;ndash;8.5 (optimum 7.0) and at NaCl concentrations of 7.5&amp;ndash;25 % (w/v) with an optimum at 10&amp;ndash;15 % (w/v). The strain required sodium and magnesium but not potassium ions for growth. Grows with tryptone, or Bacto Peptone as sole carbon and energy source and requires yeast extract for growth. It produced catalase and oxidase. The predominant ubiquinone was Q-8 and the major fatty acids comprised C18:1 &amp;omega;7c, C16:0 and C18:0. The DNA G+C content was 60.4 mol% and its polar lipids consisted of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and a phosphoglycolipid. Phylogenetic analysis based on 16S rRNA gene indicated that strain SV525T belongs to the family Ectothiorhodospiraceae within the class Gammaproteobacteria. On the basis of phylogenetic and phenotypic data, SV525T represents a novel genus and species, for which the name Halopeptonella vilamensis gen. nov., sp. nov. is proposed. The type strain is SV525T (=DSM 21056T =JCM 16388T =NCIMB 14596T).</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=e9193e4e9f8cbacd1c0d45cd47846379" target="_blank"&gt;&lt;strong&gt;Menes, Rodolfo Javier&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Viera, Claudia Elizabeth&lt;/strong&gt;</text>
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                <text>Extremophiles: life under extreme conditions v. 20, no. 1, 2016. -- p. 19-25</text>
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                <text>&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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                <text>DOI 10.1007/s00792-015-0793-7</text>
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                <text>The laminated layer is the unique mucin-based extracellular matrix that protects Echinococcus larvae, and thus to an important extent, shapes host&amp;ndash;parasite relationships in the larval echinococcoses. In 2011, we published twin reviews summarizing what was known about this structure. Since then, important advances have been made. Complete genomes and some RNAseq data are now available for E. multilocularis and E. granulosus, leading to the inference that the E.&amp;thinsp;multilocularis LL is probably formed by a single type of mucin backbone, while a second apomucin subfamily additionally contributes to the E.&amp;thinsp;granulosus LL. Previously suspected differences between E.&amp;thinsp;granulosus and E.&amp;thinsp;multilocularis in mucin glycan size have been confirmed and pinned down to the virtual absence of Gal&amp;beta;1&amp;ndash;3 chains in E.&amp;thinsp;multilocularis. The LL carbohydrates from both species have been found to interact selectively with the Kupffer cell receptor expressed in rodent liver macrophages, highlighting the ancestral adaptations to rodents as intermediate hosts and to the liver as infection site. Finally, LL particles have been shown to possess carbohydrate-independent mechanisms profoundly conditioning non-liver-specific dendritic cells and macrophages. These advances are discussed in an integrated way, and in the context of the newly determined phylogeny of Echinococcus and its taenid relatives.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>Experimental Parasitology v. 158, 2015. -- p. 23-30</text>
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                <text>Botanical biopesticides constitute an important tool for Integrated Pest Management practices. Uruguay has a great potential for developing botanical biopesticides from its abundant native flora. &lt;em&gt;Dodonaea viscosa&lt;/em&gt; Jacq. is a native Sapindaceae that in preliminary studies was shown to possess a potential deterrent activity against insect models. In this work, ethanolic extracts of the leaves of this species were studied. Bioguided fractionation and supercritical fluid extraction led to the isolation of active compounds. For that purpose four insect models were used: &lt;em&gt;Epilachna paenulata, Spodoptera littoralis, Myzus persicae&lt;/em&gt;, and &lt;em&gt;Rhopalosiphum padi&lt;/em&gt;, which are pests of crops of economic importance. Lupeol, stigmasterol, stigmast-7-en-3-ol, and a labdane diterpene were isolated and showed differential activity against the models.</text>
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                <text>&lt;strong&gt;D&amp;iacute;az, Martina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Alvarez, Ricardo Guillermo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Castillo, Luc&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gonz&amp;aacute;lez-Coloma, Azucena&lt;/strong&gt;</text>
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                <text>Journal of Plant Protection Research v. 55 , no. 2, 2015. -- p. 172-178</text>
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                <text>&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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                <text>Looking for single molecule electronic devices, we have investigated the charge transport properties of individual tetra-phenylporphyrin molecules on different substrates by ultrahigh-vacuum scanning tunneling microscopy and spectroscopy and by first-principles calculations. The tetra-phenylporphyrins with a Co atom (Co-TPP) or 2 hydrogens (H2-TPP) in the central macrocycle when deposited on Cu3Au(100) substrates showed a diode-like behavior with p and n type character, respectively. After removing the central hydrogens of H2-TPP molecule with the STM tip an ohmic behavior was measured. The rectifying effect was understood from the theoretical point of view by assuming for Co-TPP HOMO conduction and for H2-TPP LUMO conduction, both selectively elected by the hybridization of states between molecule and substrate surface.</text>
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                <text>&lt;strong&gt;Magneto structural characterization of Cu-4(PRZ)2(L)2CL-center dot -CH3CH2OH (LH=1,1-di-2-pyridyl-1-ethoximethanol : przh=pyrazole.&lt;/strong&gt;</text>
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                <text>The title compound, Cu2C17H16O2.5Cl2, is a copper(II) complex, in which each dimeric unit has two copper atoms bridged by a pyrazolato ligand, a di(2-pyridyl)]methane ligand, and an oxygen atom from the modified methylene group that links the two pyridine rings (O-C-O-CH2CH3). The complex crystallizes in the monoclinic groupP21/n,a=7.7330(1),b=19.589(6),c=13.123(2)&amp;Aring;,&amp;beta;=95.020(0)&amp;deg;,V=1980.3(7)&amp;Aring;3,Z=4,F w=514.3,D Do =1.725 g cm&amp;minus;3&amp;lambda;(MoK&amp;alpha;)=0.71073 &amp;Aring;,F(000)=1032,&amp;mu;=2.44 mm&amp;minus;1, R=0.044 for 2209 observed reflections,Rw=0.047,s=0.086. Each dimer is linked to the next unit by long chlorine bonds (Cu(2&amp;prime;)-Cl(1)=2.846(2)&amp;Aring;). These tetrameric units form zigzagged chains through copperchlorine bonds of 3.380(2)&amp;Aring;. The copper(II) complex presents antiferromagnetic behavior withT m=161 K.</text>
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                <text>The Journal of Chemical Crystallography v. 23, no. 9, 1993. -- p. 749-753</text>
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                <text>A lipoprotein fraction from fertile bovine hydatid cyst fluid (FBHCF) was isolated by affinity chromatography on acrylic-heparin. The heparin-binding lipoprotein fraction (HBLF) was proved to be free from host immunoglobulins and albumin. Immunoblotting with confirmed human hydatid sera showed that the major relevant diagnostic bands in FBHCF were also present in HBLF. HBLF or FBHCF were used to sensitize polystyrene latex particles. HBLF-latex showed both higher reactivity with positive hydatid human sera and higher batch-to-batch reproducibility than FBHCF-latex. Titration of sera from 119 surgically confirmed hydatid patients, 48 with other parasitic diseases, 6 with unrelated diseases and 37 healthy subjects was performed using HBLF-latex and conventional ELISA (using FBHCF). Sensitivity and specificity were 83 and 87% for ELISA and 87 and 88% for HBLF-latex. These results indicate that, while being simpler and faster to perform, the HBLF-latex has a similar diagnostic value to that of the conventional ELISA test.</text>
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                <text>&lt;strong&gt;Barbieri, Mariela&lt;/strong&gt;</text>
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                <text>International Journal for Parasitology v. 23, no. 5, 1993. -- p. 565-572</text>
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                <text>&lt;strong&gt;Thiolation and reversible immobilization of sweet potato beta-amylase on thiolsulfonate-agarose.&lt;/strong&gt;</text>
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                <text>Among the different methods for obtaining immobilized biocatalysts, those based on thioldisulfide exchange reactions are unique because, simultaneously, they show a stable covalent bond and the possibility of eluting the protein by reduction when the enzymatic activity decays. The adsorbent can thus be reloaded. In this paper we report the use of the recently developed thiolreactive adsorbent thiolsulfonate-agarose, for the immobilization of sweet potato &amp;beta;-amylase. Since native, &amp;beta;-amylase thiol groups were not reactive towards the adsorbent, the enzyme was provided with &amp;lsquo;de novo&amp;rsquo; thiol groups by reaction with the heterobifunctional reagent N-succinimidyl-3- (2-pyridyldithio)propionate (SPDP). When the SPDP/&amp;beta;-amylase molar ratio was changed between 3 and 100, up to sixteen exposed thiol groups per mol of enzyme were introduced. This was achieved without affecting the amylolytic activity. The immobilization yield for the intermediate thiolation level was 98%. However, only 19% of the applied enzyme activity was found in the gel suspension. Comparative studies were made on thiolsulfonate-agarose and on a commercial thiol-activated adsorbent (2-pyridyldisulfide-agarose). The immobilization of the thiolated enzyme through reversible disulfide bonds on both adsorbents showed similar results. A close analysis reveals that immobilization of proteins on thiolsulfonate-agarose is a very promising technique.</text>
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                <text>Journal of Molecular Catalysis v. 84, no. 3, 1993. -- p. 381-390</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Ab initio study of structure and reactivity of H2CO.H2O+ and related radical cations.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Coiti&amp;ntilde;o, E&lt;/strong&gt;</text>
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                <text>Journal of the American Chemical Society v. 115, no. 20, 1993. -- p. 9121-9126</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt; Isomerization of the formaldehyde radical cation and the failure of MP2.&lt;/strong&gt;</text>
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                <text>It has been reported that restricted and unrestricted MP2 ab initio calculations of the energy difference between the formaldehyde (H2CO+) and hydroxymethylene (HCOH+) radical cations are seriously in error because of poor convergence of the perturbation series. We had reported a study of the formaldehyde&amp;mdash;water radical cation and found MP2 to be reliable. A study of the correlation energy contribution to the isomeric structures formaldehyde&amp;mdash;water and hydroxymethylene&amp;mdash;water radical cations is reported. Both perturbation theory (from MP2 to MP4SDTQ) and configuration interaction (CISD and CISD(Q)) calculations were performed with the 6-311 + G(d, p) basis set at the MP2/6-311 + G(d, p) optimum geometries. The MP2 flaw in formaldehyde/hydroxymethylene is not present in the radical cations derived from the complexes with water. Analysis of our results for formaldehyde/hydroxymethylene shows that the flow is mainly connected with poor convergence of the perturbation series for the formaldehyde radical cation (and not for the hydroxymethylene). Since proton transfer occurs in the complexes with water, this species is not present in our calculations, so the results are reliable. The hydroxymethylene&amp;mdash;water radical cation is predicted to be more stable than the formaldehyde&amp;mdash;water radical cation by 29 kJ/mol on the basis of CISD(Q)/6-311 + G(d, p)//MP2/6-311 + G(d, p) calculations.</text>
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                <text>&lt;strong&gt;Coiti&amp;ntilde;o, E&lt;/strong&gt;</text>
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                <text>Chemical Physics Letters v. 202, , 1993. -- p. 479-482</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Thermodynamic activation parameters for the LDH-A4 reaction from white muscle of stenothermal and eurythermal fishes from family Sciaenidae (Perciformes).&lt;/strong&gt;</text>
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                <text>1. 1. The effect of temperature on the maximal velocity of the reaction, manifested by the Arrhenius activation energy (Ea) was determined for the LDH-A4 obtained from white muscle of four sciaenid species: Sciaenops ocellatus (eurythermal), Cynoscion striatus and Micropogonias furnieri (stenothermal) and Cheilotrema saturnum (&amp;ldquo;steno-eurythermal&amp;rdquo;). 2. 2. Ea values for LDH-A4 of the eurythermal and the steno-eurythermal sciaenids were less than the two stenothermal species. 3. 3. Maximal velocities of the LDH-A4 reactions at five different temperatures were relatively constant for S. ocellatus and C. saturnum compared to the ones obtained for the two stenothermal sciaenids. Relationships of these values to the kM values of LDH-A4 for these species were inferred. 4. 4. Low &amp;Delta;G values were obtained for the two eurythermal species, these values were much higher for the two stenothermal sciaenids.</text>
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                <text>&lt;strong&gt;Coppes, Zulema&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Larsson, P&lt;/strong&gt;</text>
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                <text>Comparative Biochemistry and Physiology - Part B v. 106, no. 1, 1993. -- p. 219-222</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
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                <text>Aims: Members of the thioredoxin (Trx) protein family participate mainly in redox pathways and have not been assocd. with&lt;br /&gt;Fe/S binding, in contrast to some closely related glutaredoxins (Grxs). Cestode parasites possess an unusual diversity of&lt;br /&gt;Trxs and Trx-related proteins with unexplored functions. In this study, we addressed the biochem. characterization of a new&lt;br /&gt;class of Trx-related protein (IsTRP) and a classical monothiol Grx (EgGrx5) from the human pathogen Echinococcus&lt;br /&gt;granulosus. Results: The dimeric form of IsTRP coordinates Fe S in a glutathione-independent manner; instead, Fe/S&lt;br /&gt;binding relies on the CXXC motif conserved among Trxs. This novel binding mechanism allows holo-IsTRP to be highly&lt;br /&gt;resistant to oxidn. IsTRP lacks canonical reductase activities. Mitochondrially targeted IsTRP aids growth of a Grx5 null&lt;br /&gt;yeast strain. Similar complementation assays performed with EgGrx5 revealed functional conservation for class II Grxs,&lt;br /&gt;despite the presence of nonconserved structural elements. IsTRP is a cestode lineage-specific protein highly expressed in&lt;br /&gt;the gravid adult worm, which releases the infective stage crit. for dissemination. Innovation: IsTRP is the first member from&lt;br /&gt;the Trx family to be reported to bind Fe/S. We disclose a novel mechanism of Fe/S coordination within the Trx folding unit,&lt;br /&gt;which renders the cluster highly resistant to oxidn.-mediated disassembly. Conclusion: We demonstrate that IsTRP defines a&lt;br /&gt;new protein family within the Trx superfamily, confirm the conservation of function for class II Grx from nonphylogenetically&lt;br /&gt;related species, and highlight the versatility of the Trx folding unit to acquire Fe/S binding as a recurrent emergent function.&lt;br /&gt;Antioxid. Redox Signal. 24, 205-216</text>
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