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&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis and additionally Leishmaniosis and Chagas disease affect approximately 30 million people. N-Acylhydrazone moiety is a repeated functional group present in several prototypes and drug candidates for these neglected diseases. On the other hand, furoxan system has been studied as pharmacophore for Leishmaniosis and Chagas diseases. Here we report on the design and preparation of forty hybrid furoxanyl N-acylhydrazones and on their activity on Mycobacterium tuberculosis, H37Rv and MDR strains, Trypanosoma cruzi, and Leishmania amazonensis. Among them, four derivatives displayed excellent to good selectivity indexes against the three different microorganisms. Hybrid compound N0-(4-phenyl-3-furoxanylmethylidene)isoniazide 9 showed the best antibacterial profile with MIC value 4.5 lesser than the value for the reference isoniazid against MDR strain. Furoxanyl N-acylhydrazone (E)-2-methyl-N0-(4-phenyl-3-furoxanylmethylidene)-4H-imidazo[1,2-a] pyridine-3-carbohydrazide 15 was ten-fold more potent against T. cruzi Amastigotes than the standard drug nifurtimox. On the other hand, derivatives (E)-N0-(5-benzofuroxanylmethylidene)benzo[d][1,3] dioxole-5-carbohydrazide 25 and (E)-N0-(4-hydroxy-3-methoxyphenylmethylidene)-3-methylfuroxan-4- carbohydrazide 37 emerged as leads for the development of new leishmanicidal agents. The adequate stability, in simulated biological system and plasma, and the lack of mutagenicity of these derivatives allow us to propose them as candidates for further pre-clinical studies.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Hybrid nanostructured supports for magnetic hyperthermiamediated activation of enzymes&lt;/strong&gt;</text>
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                <text>La nanobiotecnolog&amp;iacute;a se ha beneficiado recientemente del uso de nanobiocatalizadores inmovilizados aplicados a la biorremediaci&amp;oacute;n, bioprocesos sint&amp;eacute;ticos y biomedicina, entre otros campos. La integraci&amp;oacute;n enzim&amp;aacute;tica en materiales h&amp;iacute;bridos permite capitalizar las ventajas sin&amp;eacute;rgicas de los diferentes materiales estructurales para mejorar las propiedades del biocatalizador. En esta tesis, hemos estudiado la s&amp;iacute;ntesis de nanopart&amp;iacute;culas nanoh&amp;iacute;bridas [silica biomim&amp;eacute;tica + nanopart&amp;iacute;culas magn&amp;eacute;ticas (MNPs)] como un veh&amp;iacute;culo de peroxidasa de r&amp;aacute;bano picante (HRP) para su uso en la terapia dirigida de prof&amp;aacute;rmacos de enzimas (DEPT). DEPT usa enzimas ex&amp;oacute;genas introducidas artificialmente en el cuerpo con el objetivo de convertir prof&amp;aacute;rmacos en su forma activa en el sitio deseado del organismo y, por lo tanto, tiene una ventaja sobre las terapias est&amp;aacute;ndar no espec&amp;iacute;ficas por su selectividad potencial. El uso de enzimas enzapsuladas o unidas a nanopart&amp;iacute;culas (NPs) ha ganado inter&amp;eacute;s en este tipo de terapia ya que permite mejorar la estabilidad y reducir la inmunogenicidad de la enzima terap&amp;eacute;utica, a la vez que mejorar la bioacumulaci&amp;oacute;n y retenci&amp;oacute;n de la enzima en el tejido tumoral. Esto es debido al efecto de retenci&amp;oacute;n y permeabilidad aumentada (EPR) por la presencia de una abundante vascularizaci&amp;oacute;n inmadura en el tumor que hace que de forma pasiva se acumulen mayor cantidad de NPs que en tejidos sanos. Por tanto, las enzimas terap&amp;eacute;uticas transportada por NPs tienen una mayor facilidad en acumularse en tejidos tumorales que la misma enzima administrada en forma libre. Sin embargo, las NPs no pueden evitar la distribuci&amp;oacute;n no selectiva en el cuerpo, sobre todo en &amp;oacute;rganos que para filtrar la sangre tambi&amp;eacute;n usan el efecto EPR (h&amp;iacute;gado, bazo)., Por lo tanto, el uso exitoso de modalidades de DEPT que utilicen nanomateriales como veh&amp;iacute;culos de la enzima terap&amp;eacute;utica depende de la implementaci&amp;oacute;n de estrategias que puedan proporcionar un control espaciotemporal sobre su actividad enzim&amp;aacute;tica. Para esto, en esta Tesis se ha optimizado la co-encapsulaci&amp;oacute;n de MNP junto con la enzima terap&amp;eacute;utica HRP en nanopart&amp;iacute;culas de s&amp;iacute;lica biomim&amp;eacute;tica. Se eligi&amp;oacute; HRP debido a su capacidad para convertir el &amp;aacute;cido indol-3-ac&amp;eacute;tico (hormona vegetal) en radicales peroxilados con actividad citot&amp;oacute;xica en varias l&amp;iacute;neas celulares tumorales. Sin embargo, la HRP tiene una temperatura &amp;oacute;ptima de 45&amp;ordm;C y a la temperatura corporal su actividad biocatal&amp;iacute;tica no es m&amp;aacute;xima. Debido a que las MNPs pueden absorber energ&amp;iacute;a en presencia de un campo magn&amp;eacute;tico alterno externo (AMF) y liberarla al medio ambiente en forma de calor, nuestra hip&amp;oacute;tesis de trabajo se centra en lograr utilizar este calor para 3 alcanzar la temperatura &amp;oacute;ptima de la HRP de forma localizada (en una escala nanom&amp;eacute;trica), y as&amp;iacute; incrementar su actividad enzim&amp;aacute;tica. Tradicionalmente, el desencadenar el aumento macrosc&amp;oacute;pico de la temperatura de tejidos tumorales ha sido la estrategia m&amp;aacute;s difundida para utilizar el gradiente muy alto de temperatura que se genera por calentamiento magn&amp;eacute;tico en pocos nan&amp;oacute;metros desde la superficie de la MNPs. Esto ha permitido el desarrollo de una nueva terapia para el tratamiento del c&amp;aacute;ncer, conocida como hipertermia magn&amp;eacute;tica (MHT), ya que las c&amp;eacute;lulas tumorales tienen una mayor sensibilidad al calor que las c&amp;eacute;lulas normales. En esta Tesis sin embargo proponemos aprovechar este gradiente de temperatura localizado alrededor de las MNPs no para desencadenar que se eleve de forma macrosc&amp;oacute;pica la temperatura de un tejido tumoral sino para modular la aactividad de enzimas co-entrapadas con las MNPs en nanoh&amp;iacute;bridos de s&amp;iacute;lica biomim&amp;eacute;tica. El uso de silica biomim&amp;eacute;tica en el nanoh&amp;iacute;brido se plante&amp;oacute; bajo la premisa de utilizar un medio para estabilizar la enzima, que permita su probable inmunoaislaci&amp;oacute;n y, como se demostr&amp;oacute; m&amp;aacute;s tarde, alcanzar a su vez un posible efecto de aislamiento t&amp;eacute;rmico que disminuya la r&amp;aacute;pida disipaci&amp;oacute;n de calor que ocurre a pocos nm de la superficie de las MNPs y as&amp;iacute; sea posible modular la actividad de enzimas que no se encuentren unidas a la superficie de las MNPs. Es as&amp;iacute; que efectivamente la estrategia de co-encapsulaci&amp;oacute;n facilit&amp;oacute; un aumento selectivo en la actividad biocatal&amp;iacute;tica de HRP al alcanzar localmente su temperatura &amp;oacute;ptima. Para llegar a esta conclusi&amp;oacute;n, hemos optimizado la s&amp;iacute;ntesis de los nanoh&amp;iacute;bridos variando diferentes par&amp;aacute;metros tales como: i) tama&amp;ntilde;o del catalizador aminado requerido para la formaci&amp;oacute;n de NP de s&amp;iacute;lica (polietilenimina MW ~ 1300, 2000, 25000, 60000 Da), ii) metodolog&amp;iacute;a de inmovilizaci&amp;oacute;n de la HRP (adsorci&amp;oacute;n / uni&amp;oacute;n covalente en MNP antes de la encapsulaci&amp;oacute;n, co-encapsulaci&amp;oacute;n con MNP), iii) relaci&amp;oacute;n HRP/ MNP. La inmovilizaci&amp;oacute;n de HRP y los rendimientos de actividad despu&amp;eacute;s del atrapamiento son similares con o sin MNP (~ 60 &amp;plusmn; 4% y 78 &amp;plusmn; 1, respectivamente). Sin embargo, la estabilidad t&amp;eacute;rmica de la enzima (50&amp;ordm;C) aument&amp;oacute; 532 (Factor de estabilizaci&amp;oacute;n) cuando la HRP se co-encapsula con MNP. El uso de PEI de diferentes tama&amp;ntilde;os no afect&amp;oacute; los rendimientos de la inmovilizaci&amp;oacute;n de HRP ni el tama&amp;ntilde;o (di&amp;aacute;metro hidrodin&amp;aacute;mico) de los h&amp;iacute;bridos. Sin embargo, las MNP parecen actuar como plantillas para la deposici&amp;oacute;n de s&amp;iacute;lice ya que su co-encapsulaci&amp;oacute;n con HRP reduce el tama&amp;ntilde;o radio de los bioh&amp;iacute;bridos (de ~ 800-1000 a 500-600 nm). Todos los nanoh&amp;iacute;bridos obtenidos pudieron oxidar IAA, pero no se observ&amp;oacute; citotoxicidad en 4 ausencia del prof&amp;aacute;rmaco usando diferentes l&amp;iacute;neas celulares. Tambi&amp;eacute;n hemos estudiado el efecto del tama&amp;ntilde;o del catalizador aminado requerido para la formaci&amp;oacute;n del nanobiocatalizador (polietilenimina MW ~ 1300, 2000, 25000, 60000 Da), en su eficiencia de calentamiento magn&amp;eacute;tico macrosc&amp;oacute;pico (SAR, Specific Absorption Rate o tasa de absorci&amp;oacute;n espec&amp;iacute;fica) y nanosc&amp;oacute;pico (activaci&amp;oacute;n enzim&amp;aacute;tica). Los nanoh&amp;iacute;bridos (500-600 nm) mostraron activaci&amp;oacute;n enzim&amp;aacute;tica (250-300%) sin un aumento significativo de la temperatura macrosc&amp;oacute;pica y conservaron su actividad completa despu&amp;eacute;s de la aplicaci&amp;oacute;n de un ciclo de AMF (829 kHz, 25.2 mT) durante 20 min. Sin embargo, para que los nHs desarrollados puedan tener potencial para ser utilizados en DEPT es clave que presenten buena estabilidad coloidal en medios biol&amp;oacute;gicos complejos. Para ello fue necesario bloquear grupos amino primarios presentes en la superficie de los mismos con glucosa. Este mon&amp;oacute;socar&amp;aacute;ido no solo permiti&amp;oacute; mejorar la estabilidad coloidal de los nHs en medio de cultivo completo, pero tambi&amp;eacute;n sirve de biomol&amp;eacute;culta para vectorizaci&amp;oacute;n activa de c&amp;eacute;lulas tumorales. Los nanoh&amp;iacute;bridos funcionalizados con glucosa lograron diferencias significativas en la reducci&amp;oacute;n de la viabilidad celular de una l&amp;iacute;nea celular de c&amp;aacute;ncer de colon humano (HCT-116) despu&amp;eacute;s de la exposici&amp;oacute;n a un ciclo de AMF (80% versus 30% de reducci&amp;oacute;n en controles sin aplicaci&amp;oacute;n de AMF). Estos resultados muestran por primera vez que es posible controlar de forma remota la actividad de HRP co-atrapada con MNP mediante calentamiento magn&amp;eacute;tico para una potencial aplicaci&amp;oacute;n en terapia antitumoral DEPT.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>For glutathione reductase (GR), amammalian reduced nicotinamide adenine dinucleotide phosphate dependent &amp;macr;avoenzyme participating in free-radical detoxi&amp;reg;cation pathways, we present a quantum chemical study addressing aspects of its electronic mechanism. The system is known to sustain both ping-pong and sequentially ordered mechanisms depending upon par- ticular conditions. Isoalloxazine and nicotinamide- N-protonated rings are taken as a minimum model. The AM1 method and the AMSOL program are used throughout. Starting from a transition-state structure, docked at GRs active site, and successively including molecular elements of the active site relevant to the redox processes, geometry-optimized binary and tertiary complexes are characterized suggesting a plausible description for the sequentially ordered mechanism. The ping-pong mechanism relates to an electron-transfer (ET) mechanism. An ET binary complex between nicotinamide and the isoalloxazine ring was character- ized. Its electronic structure is controlled by the proto- nation state of the proton relay found at this active site. The excess proton in the relay comes from the previous hydride-transfer step. The experimental stereoselectivity is then ful&amp;reg;lled. The state of charge (standard Mulliken population analysis) shows an excess of two electrons on the isoalloxazine ring and almost one on the nicotin- amide ring. The overall results suggest that both mechanisms can be controlled by the same hydride- transfer structure, the dierence between them being determined by changes in the oxidized coenzyme binding strength to the protein and/or the strength of the protein&amp;plusmn;substrate interactio</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=61cb9707d2f1b34e7a18f0e5255264e0"&gt;&lt;strong&gt;Iribarne, Federico&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Tapia, Orlando.&lt;/strong&gt;</text>
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                <text>Theoretical Chemistry Accounts v. 103, no. 6, 2000. -- p. 451-462</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Hydrochemical analysis and evaluation of water quality in the Salto-Arapey aquifer and San Antonio Creek, Salto, Uruguay, as a diagnosis for water resources management&lt;/strong&gt;</text>
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                <text>CALIDAD DEL AGUA</text>
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                <text>Salto district, a key horticultural area in Uruguay, has crucial water sources such as the Guarani Aquifer System, the Salto-Arapey Aquifer System (SAAS), and the San Antonio Creek (SAC). Agricultural and livestock activities have increased in recent years, leading to demographic growth and housing expansion. Concerns about water quality arise due to limited studies on environmental exposure to harmful chemicals and microbiological factors from agriculture, inadequate wastewater treatment, and septic tank seepage in rural areas. The present study collected hydrochemical background and new sampling data for hydrogeochemical and water quality evaluation (28 parameters) from SAAS (73 wells) and SAC (6 sites). Results indicated groundwater from SAAS is mainly sodium bicarbonate type, RAS index shows low saline waters and microbiological contamination were detected in half of the sampled wells, As levels (4.0–49.3 μgL−1), total phosphorus (P) (50–178.5 mg/L), and nitrate (NO− 3 ) (7.0–168.5 mg/L). SAC hydrochemistry revealed high levels of P (77.5–163.5 μg/L), which could be one of the factors that promote the appearance of signs of eutrophication towards the mouth of the Uruguay River. Spatial distribution of total arsenic (As) in SAAS and water quality evaluation of SAC assess future human health risks. These results represent a challenge to foster Uruguayan water education and raise public awareness about the importance of using safe water for human consumption and irrigation.</text>
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                <text>&lt;strong&gt;Alvareda, Elena&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gimenez, Manuel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ramos, Julián&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Borrero, Armando&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Texo, Andrea&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Bessone, Lucas&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Abelenda, Esteban&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Saracho, Andrés&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Navas, Rafael&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Bühl, Válery&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Da Rocha, Sofía&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gamazo, Pablo&lt;/strong&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Environmental Monitoring and Assessment, v. 197, n° 6, 2025. -- e674</text>
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            <elementTextContainer>
              <elementText elementTextId="709416">
                <text>&lt;p&gt;&lt;strong&gt;Información sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;La legislación uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                  <text>Bibliografía Nacional Química</text>
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                <text>&lt;strong&gt;Hydrogen bonding in ortho-substituted arylamides : The influence of protic solvents&lt;/strong&gt;</text>
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                <text>We combine molecular modeling and NMR methods to better understand intramolecular hydrogen bonding (H-bonding) in a frequently used arylamide foldamer building block, ortho-methoxy-N-methylbenzamide. Our results show that solvents have a profound influence on the cumulative number and stabilizing effects of intramolecular H-bonds, and thus conformational preferences, of foldamers based on this compound. While intramolecular H-bonds are conserved in aprotic environments, they are significantly disrupted in protic solvents. Furthermore, these solvent effects can be accurately quantified using the computational approach presented here. The results could have significant implications in foldamer design, particularly for applications in aqueous environments</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>In this work, an upflow anaerobic packed bed reactor configuration to produce hydrogen using cheese whey as the substrate was tested. The microbiological composition was linked to the reactor operation.&lt;br /&gt;&lt;br /&gt;Three different organic loading rates of 22, 33, and 37 g COD/L-d were used at a fixed hydraulic retention time of 24 h. The increase of the organic loading rate from the initial value of 22 g COD/L-d to a value of 37 g COD/L-d and the adjustment of the pH to values greater than 5 had a positive effect on the hydrogen production and values of up to 1 L H2/L-d were achieved. The production of hydrogen was stable under all of the investigated conditions, and the problems frequently reported in this kind of reactors (bed clogging, methanogenesis and solvent production) were not observed during operation.&lt;br /&gt;&lt;br /&gt;The highest hydrogen yield was 1.1 mol H2/mol lactose far from the maximum theoretical value (8 mol H2/mol lactose), but similar to previous works using cheese whey as substrate. The microbiological analysis showed a mixed population with a low proportion of hydrogen-producing fermenters (Clostridium and Klebsiella) and other non-hydrogen-producing organisms.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>International Journal of Hydrogen Energy v. 38, no. 1, 2013. -- p. 54-62</text>
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                <text>&lt;p&gt;Biofuel production from biomass sources emerges as a promising alternative to solve the actual environmental crisis and lead to a transition to a carbon-free future. In this sense, hydrogen produced through steam reforming of a biomass-derived biofuel, such as bio-oil, appears as an interesting energetic vector. The aim of this work is the hydrogen production through steam reforming of small organic model compounds present in the aqueous fraction of bio-oil (ethanol, acetic acid, acetone) and, for a better approximation to a real system, emulate such aqueous fraction by a representative mixture of these. Ternary mixed oxides Ni-La-Me catalysts (Me = Ce, Ti, Zr) were prepared, characterized through X-ray diffraction, N2 adsorption&amp;ndash;desorption isotherms, thermogravimetric analysis, cyclic voltammetry, and scanning electron microscopy, and tested in the steam reforming reactions. Results indicate that, due to the intrinsic H2O&lt;br /&gt;adsorption capacity of ZrO2 as well to a higher number of oxygen vacancies in the catalyst structure, Ni-La-Zr presents interesting properties for its potential applicability as industrial catalyst for hydrogen production through steam reforming. On the other hand, the strong metal-support interactions on Ni-La-Ti led to a lower catalytic activity caused by a lower segregation of Ni crystallites from the mixed oxide structure.&lt;/p&gt;</text>
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                <text>AB2 alloys have been extensively studied as Ni-MH battery anodes. In the hydriding process, hydrogen diffusion inside the crystal lattice is the determining step, so a comparison between gas phase and electrochemical environment was carried out. As concern, we have found structural changes as a consequence of hydriding in terms of segregation of different stable phases and variations in unit cell parameters in each alloy. Maximum hydrogen storage capacity and hydrogen molar volume for studied alloys were evaluated by PCT curves at different temperatures. Resulting values were compared with electrochemical PCT (ECT plots). Results obtained for both methods were similar, with a hydrogen molar volume value close to 30 cm3 mol-1 being higher for AB2M0 in accordance with the reported capacity values. Diffusion time constants were determined from GITT, achieved data were similar to previously reported by EIS and HRD. AB2M1 alloy showed the best kinetic behavior, depicting a time constant value an order of magnitude lower than AB2M0. This fact could be attributed to the diffusion coefficient and/or the hydrogen diffusion length mean path. No significant differences in thermodynamic parameters were observed between both alloys, therefore, the diffusion coefficients should be similar. Thus, differences in time diffusion constants were attributed to dissimilar mean lattice diffusion paths associated with changes in crystalline structures as a result of the hydriding process.&#13;
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                <text>Journal of Electroanalytical Chemistry v. 879, 2020. -- p. 1-17.--e.114781&#13;
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                <text>The production of H2-rich gaseous mixtures from steam and oxidative steam reforming of crude glycerol was investigated on catalysts with general formula Ni(12&amp;thinsp;wt.%)-La2(Ce1-xZrx)2O7 (x&amp;thinsp;=&amp;thinsp;0, 0.5, 1). The catalysts were prepared by the polymerized complex method based on the Pechini-type reaction route and characterized by a variety of physical and spectroscopic techniques. Samples were calcined in air at 850&amp;thinsp;&amp;deg;C for 4&amp;thinsp;h. All catalysts showed a well-defined NiO phase and a mixed oxide with a general formula A2B2O7 (A: La; B: Ce and/or Zr). NiO was completely reduced to metallic Ni on all catalysts under pure H2 at 650&amp;thinsp;&amp;deg;C. Ni reducibility is favored by the presence of Ce. Redox properties of Ce can also explain a synergetic effect leading to the higher basicity of the catalyst containing Ce and Zr (x&amp;thinsp;=&amp;thinsp;0.5). Catalytic tests were performed at 650&amp;thinsp;&amp;deg;C by feeding the fixed-bed tubular reactor with a crude glycerol:water solution containing 30&amp;thinsp;wt% glycerol. The best results were achieved on the catalyst displaying the highest basicity (Ni-La2(Ce0.5Zr0.5)2O7 both under steam and oxidative reforming conditions. Removal of carbon and alkali metals by simple procedures allows to a significant recovery of the initial catalytic activity without changes in their chemical and phase structure.</text>
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                <text>Herein, we investigate the chemisorption of hydrogen on double wall carbon nanotubes �DWCNT� employing density functional theory and periodic boundary conditions. In agreement with recent investigations based on Lennard-Jones potentials, we found that the �n,m�@�n+9,m� combination is favored for tubes with small diameters. The C&amp;ndash;H binding energies determined for the �16,0� single wall carbon nanotubes �SWCNT� are nearly identical to those computed for the �7,0�@�16,0� and �8,0�@�16,0� DWCNTs. For both of the latter we found that interlayer interaction modifies the band structure of the inner tube. In the case of hydrogenated DWCNTs, the electronic structure of the inner tube experiences very small changes at high coverages �50%�. However, at lower hydrogen coverages �3%&amp;ndash;25%� changes are observed in the electronic structure of the inner tube. In agreement with recent experimental results we conclude that, for heavily functionalized DWCNTs, the electronic properties of the inner tube remain unchanged. For zigzag SWCNTs, the band gap becomes larger upon increase in hydrogen coverage; at 50% of coverage the hydrogenated �16,0� SWCNT has a band gap of 3.38 eV. Finally, based on the fact that high coverages significantly elongate C&amp;ndash;H bond distances, we propose that the hydrogenation coverage may be determined measuring the C&amp;ndash;H vibrational modes</text>
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                <text>First-principles density functional theory calculations are performed to study the stability and electronic properties of hydrogenated and fluorinated two-dimensional sp3 boron phosphide (BP) and boron arsenide (BAs). As expected, the phonon dispersion spectrum and phonon density of states of hydrogenated and fluorinated BX (X = P, As) systems are found to be different, which can be attributed to the different masses of hydrogen and fluorine. Hydrogenated BX systems bear larger and indirect band gaps and are found to be different from fluorinated BX systems. These derivatives can be utilized in hydrogen storage applications and ultrafast electronic devices. Finally, we investigated the stability and electronic properties of stacked bilayers of functionalized BP. Interestingly, we found that these systems display strong interlayer interactions, which impart strong stability. In contrast with the electronic properties determined for the fluorinated/hydrogenated monolayers, we found that the electronic properties of these bilayers can finely be tuned to a narrow gap semiconductor, metallic or nearly semimetallic one by selecting a suitable arrangement of layers. Moreover, the nearly linear dispersion of the conduction band edge and the heavy-, light-hole bands are the interesting characteristics. Furthermore, the exceptional values of effective masses assure the fast electronic transport, making this material very attractive to construct electronic devices.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Background: Scintigraphic studies have been performed to assess the release, both in vitro and in vivo, of radiotracers from tablet formulations. Four different tracers with differing physicochemical characteristics have been evaluated to assess their suitability as models for drug delivery. Methods: In-vitro disintegration and dissolution studies have been performed at pH 1, 4 and 7. Invivo studies have been performed by scintigraphic imaging in healthy volunteers. Two hydrophilic tracers, (99mTc-DTPA) and (99mTc-MDP), and two lipophilic tracers, (99mTc-ECD) and (99mTc-MIBI), were used as drug models. Results: Dissolution and disintegration profiles, differed depending on the drug model chosen. In vitro dissolution velocity constants indicated a probable retention of the radiotracer in the formulation. In vivo disintegration velocity constants showed important variability for each radiopharmaceutical. Pearson statistical test showed no correlation between in vitro drug release, and in vivo behaviour, for 99mTc-DTPA, 99mTc-ECD and 99mTc-MIBI. High correlation coefficients were found for 99mTc-MDP not only for in vitro dissolution and disintegration studies but also for in vivo scintigraphic studies. Conclusion: Scintigraphic studies have made a significant contribution to the development of drug delivery systems. It is essential, however, to choose the appropriate radiotracers as models of drug behaviour. This study has demonstrated significant differences in release patterns, depending on the model chosen. It is likely that each formulation would require the development of a specific model, rather than being able to use a generic drug model on the basis of its physicochemical characteristics.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>SnS2 has adequate properties for photovoltaic applications in solar cells. For this purpose, we studied the influence of the capping agents pyridine and aniline in the nanoparticles hydrothermal syntheses. These capping agents are suitable for use in hybrid organic- inorganic solar cells. Different ratios of these agents with respect to the metal precursor were tested. Hexagonal and disc-type nanoparticles were obtained. Lower concentrations of capping agent increased the proportion of hexagons, while diminishing their size. The obtained products are adequate in size, dispersion of size, and stabile in suspension in chloroform to use them in hybrid solar cells. Moreover, the use ofpyridine allowed for more stable suspensions, and therefore better results for this application.</text>
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                <text>We synthesized HgS nanostructures by the hydrothermal method in order to use them as electron acceptors in hybrid organic-inorganic solar cells. We employed different mercury sources (HgO and Hg(CH3COO)2) and polyvinylpyrrolidone (PVP) or hexadecanethiol (HDT) as stabilizing/capping agent for controlling size, crystallinity, morphology and stability of the obtained nanostructures. We also used thiourea as sulfur source, and a temperature of 180 &amp;deg;C during 6 h. Synthesized nanostructures were characterized by powder X-Ray Diffraction, Diffuse Reflectance Infrared Fourier Transform and Transmission Electron Microscopy. When PVP acts as stabilizing agent, the mercury source has influence on the size -but not in morphology- of the beta-HgS obtained nansostructures. HDT has control over nanostructures&amp;rsquo; size and depending on the relation Hg:HDT, we obtained a mixture of alpha and beta HgS which can be advantageous in the application in solar cells, due their absorption in different spectral regions. The smallest nanostructures obtained have a mean diameter of 20 nm when using HDT as capping agent. Also, we deposited the aforementioned nanostructures onto flat glass substrates by the spin coating technique as a first approach of an active layer of a solar cell. The depositions were characterized by atomic force microscopy. We obtained smaller particle deposition and higher particle density -but a lower area coverage (5%) &amp;ndash; in samples with HDT as capping agent. This work presents promising results on nanostructures for future application on hybrid solar cells. Further efforts will be focused on the deposition of organic-inorganic layers.</text>
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                <text>A density functional study of the neutral and ionic chelates of boric acid with formohydroxamic acid is performed. Optimum structures were determined for the chelates, and the IR spectrum for the bis(hydroxamate) boron chelate was compared to the experimental spectrum obtaining an excellent agreement. Two bands that were unassigned experimentally were identified with the aid of the theoretical calculations. The enthalpies of formation of formohydroxamic acid (&amp;minus;50.2&amp;plusmn;2 kcal/mol) as well as those of the bis(hydroxamate), hydroxamate&amp;ndash;hydroximate and bis(hydroximate) boron chelates (3.8&amp;plusmn;2, &amp;minus;145&amp;plusmn;2 and &amp;minus;155&amp;plusmn;2 kcal/mol, respectively) were determined.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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