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                <text>This study illustrates a procedure for producing different high-performance liquid chromatography (HPLC) stationary phases, on demand, for silica monoliths. Two commercial first-generation analytical scale bare silica monoliths were subjected to a &amp;ldquo;remodification&amp;rdquo; process that involved the following: (1) coating of the silica through an in situ silylation procedure to bond ligands of choice to the surface, (2) periodic chromatographic characterization of the coated surface over 2,000 column volumes, and (3) removing the bonded ligands using a 0.1 M hydrochloric (HCl) acid wash, to regenerate the initial silica surface. This remodification protocol was repeated for three cycles to fabricate monoliths with selected functionalities. To test reproducibility, this study was conducted on two different commercial silica monoliths subjected to this treatment involving synthetic reactions with organo-silanes and subsequent stripping with acid washes. Both monoliths were functionalized with three different coatings, without significant degradation of the initial columns' silica infrastructure and excellent stability (tested up to 2,000 column volumes). One of the monoliths had measured theoretical plates per meter (N/m) of 57,000 N/m for the original silica surface, 105,000 N/m for the first cyano coating, and 60,000 N/m for the third phenyl coating. The stationary phases prepared by remodification possessed similar selectivities to those synthesized from new silica monoliths. The results of the Tanaka test shows evidence of residual ligands of previous coatings. However, the methylene and phenyl selectivity proved to display the same characteristics as other modified monoliths of the same functionality, not subjected to the remodified proces</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Enzymatic synthesis of 3-aminopropyl-1-O-&amp;beta;-Dgalactopyranoside catalyzed by Aspergillus oryzae &amp;beta;-galactosidase&lt;/strong&gt;</text>
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                <text>Glycosidases represent excellent green chemistry alternatives as catalysts for the synthesis of glycosides, and in particular their stereoselectivity allows the production of anomerically pure glycosides, in only one reaction step using mild reaction conditions. Here, we report the enzymatic synthesis and structural characterization of 3-aminopropyl-1-O-&amp;beta;-D-galactopyranoside. Optimal reaction conditions for the transgalactosylation reaction were 100&amp;thinsp;mM lactose, 500&amp;thinsp;mM 3-amino-1-propanol and 24 h of incubation at 50&amp;thinsp;&amp;deg;C with 6 U/mL of &amp;beta;-galactosidase from Aspergillus oryzae. The fact that the synthesis of 1-propyl-2-O-&amp;beta;-D-galactopyranoside using 1-amino-2-propanol as acceptor was not achieved, and that N-glycoside formation was not observed, confirms the selectivity of &amp;beta;-galactosidase for the synthesis of O-glycosides, and particularly for primary alcohols. The synthesized galactosides were evaluated for their ability to interact with bovine spleen galectin-1 (Gal-1) by using the hemagglutination inhibition assay; results demonstrated that 3-aminopropyl-1-O-&amp;beta;-D-galactopyranoside may be considered as a functionalized galactose moiety more than an efficient Gal-1 inhibitor. The proposed approach constitutes a promising tool for the generation of glycopolymers and glyconanoparticles with potential applications in the development of biosensors as well as construction blocks in chemical synthesis.</text>
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                <text>&lt;strong&gt;Porci&amp;uacute;ncula Gonz&amp;aacute;lez, Cecilia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rodr&amp;iacute;guez, Ernesto&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1502d6d114aace9e148166840e515f38" target="_blank"&gt;&lt;strong&gt;Soul&amp;eacute;, Silvia&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=729d3d9bb07d7be0ba5e4dc762c01e29" target="_blank"&gt;&lt;strong&gt;Franco Fraguas, Laura&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Biocatalysis and Biotransformation v. 33, no. 4, 2015. -- p. 197-207</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Within all the eukaryotic cells myo-inositol phosphates (InsPs) are an important group of biomolecules that are potentially related to signaling functions. The most abundant member of this family in nature is InsP6 (phytate, L(12-) in its fully deprotonated form). The complicated chemical behavior of this molecule demands a great effort to understand its function in the cell medium. In this work we follow our earlier studies on the interaction of InsP6 with metal cations by inclusion of polyamines (both biogenic and synthetic) as potential agents to produce stable adducts. The stability constants of InsP6-amine adducts and the relevant thermodynamic parameters &amp;Delta;G&amp;deg;, &amp;Delta;H&amp;deg;, and &amp;Delta;S&amp;deg; were determined at 37.0 &amp;deg;C and 0.15 M ionic strength by means of potentiometric titrations and isothermal titration calorimetry (ITC). The biogenic amines studied were 1,4-diaminobutane (putrescine, put), 1,5-diaminopentane (cadaverine, cad), N-(3-aminopropyl)-1,4-diaminobutane (spermidine, spd), N,N'-bis(3-aminopropyl)-1,4-diaminobutane (spermine, spm), and 1-(4-aminobutyl)guanidine (agmatine, agm), while the synthetic models of longer polyamines were 1,19-dimethyl-1,4,7,10,13,16,19-heptaazanonadecane (Me2hexaen), 1,22-dimethyl-1,4,7,10,13,16,19,22-octaazadocosane (Me2heptaen), 1,25-dimethyl-1,4,7,10,13,16,19,22,25-nonaazapentacosane (Me2octaen) and N,N'-bis(3-aminopropyl)-1,3-propanediamine (3,3,3-tet). With the aid of molecular modeling, we also studied the structural aspects of molecular recognition in operation. The final result is a balance between many parameters including charge of the species, flexibility of the amines, H-bonds in the adduct, and desolvation processes.</text>
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                <text>Organic and Biomolecular Chemistry v. 13, no. 27, 2015. -- p. 7500-7512</text>
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                <text>Royal Society of Chemistry</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>Art&amp;iacute;culo</text>
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                <text>DOI: 10.1039/C5OB00900F</text>
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        <name>Myo-inositol</name>
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        <name>Química Inorgánica</name>
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                  <text>Bibliografía Nacional Química</text>
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              <description>An account of the resource</description>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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          <element elementId="50">
            <name>Title</name>
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                <text>&lt;strong&gt;Evoluci&amp;oacute;n hist&amp;oacute;rica de un programa de evaluaci&amp;oacute;n externa de calidad en un laboratorio cl&amp;iacute;nico&lt;/strong&gt;</text>
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                <text>CALIDAD</text>
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                <text>LABORATORIO CLINICO</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>2015</text>
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                <text>&lt;strong&gt;Raymondo, Stella&lt;/strong&gt;</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="350430">
                <text>Asociaci&amp;oacute;n de Qu&amp;iacute;mica y Farmacia del Uruguay no. 72, 2015. -- p. 15-22</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="350431">
                <text>Asociaci&amp;oacute;n de Qu&amp;iacute;mica y Farmacia del Uruguay</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2015</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="350433">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>Espa&amp;ntilde;ol</text>
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                <text>ISSN 0797-9150</text>
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                <text>&lt;strong&gt;Isolation and structural characterization of new piperidine alkaloids from Prosopis affinis&lt;/strong&gt;</text>
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                <text>ALCALOIDES</text>
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                <text>PROSOPIS AFFINIS</text>
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                <text>&amp;Ntilde;ANDUBAY</text>
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                <text>The isolation of three new N-methylated piperidine-3-ol alkaloids from the bark of Prosopis affinis Spreng. (&amp;Ntilde;andubay) is described. Together with MS and IR data, results from 1D and 2D NMR experiments allowed for the identification of N‑methyl-2-isocassine, N‑methyl-6-isocassine, and N‑methyl-6-isocarnavaline. Inspection of 1D-NOESY spectra and coupling constant data revealed that the heterocyclic moiety of the alkaloids is in fast conformational equilibrium in solution, and this behavior had to be taken into account in order to determine the relative configuration of the chiral centers of the piperidine rings.</text>
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                <text>&lt;strong&gt;Reina, Luis&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Bennadji, Zohra&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Vinciguerra, Vittorio&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=0933731a43508cea8800ee7ee13daf0a" target="_blank"&gt;&lt;strong&gt;Moyna, Guillermo&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=c63a421d8a96930bcc9fb16ef3819110" target="_blank"&gt;&lt;strong&gt;Men&amp;eacute;ndez, Pilar&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Phytochemistry Letters v. 14, 2015. -- p. 265-269</text>
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                <text>In search of prospective agents against infectious diseases, 1,1'-bis(diphenylphosphino)ferrocene pyridine-2-thiolato-1-oxide M(ii) hexafluorophosphate compounds [M(mpo)(dppf)](PF6), where M = palladium or platinum, were synthesized and fully characterized in the solid state and in solution using experimental and DFT computational techniques. The compounds are isomorphous and the M(ii) transition metal ions are in a nearly planar trapezoidal cis-coordination bound to the pyridine-2-thiolato-1-oxide (mpo) and to the 1,1'-bis(diphenylphosphino)ferrocene molecules, both acting as bidentate ligands. Both compounds showed high cytotoxic activity on Trypanosoma cruzi and Mycobacterium tuberculosis (MTB) and acceptable selectivities towards MTB, but good to excellent selectivity index values as anti-T. cruzi compounds. The inclusion of the ferrocene moiety (dppf ligand) improved the selectivity towards the parasite when compared to the previously reported [M(mpo)2] complexes. Related to the probable mechanism of action of the complexes, molecular docking studies on modelled T. cruzi NADH-fumarate reductase (TcFR) predicted that both be very good inhibitors of the enzyme. The effect of the compounds on the enzyme activity was experimentally confirmed using T. cruzi protein extracts. According to all obtained results, both [M(mpo)(dppf)](PF6) compounds could be considered prospective anti-trypanosomal agents that deserve further research.</text>
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                <text>Dalton Transactions v. 44, no. 32, 2015. -- p. 14453-14464</text>
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                <text>As part of our efforts to develop organometallic ruthenium compounds bearing activity on both trypanosomatid parasites and tumor cells, a new Ru(II)&amp;ndash;cyclopentadienyl clotrimazole complex, [RuCp(PPh3)2(CTZ)](CF3SO3), where Cp = cyclopentadienyl, CTZ = clotrimazole, was synthesized and characterized. The compound was evaluated in vitro on T. cruzi (Y strain), the infective form of T. brucei brucei strain 427 (cell line 449), on three human tumor cell lines with different sensitivity to cisplatin (A2780, ovary; MCF7, breast; HeLa, cervix) and on J774 murine macrophages as mammalian cell model. The new compound is more cytotoxic on T. cruzi and on the tumor cell lines than the reference drugs (Nifurtimox and cisplatin, respectively). In addition, complexation of the bioactive CTZ to the {RuCp(PPh3)} moiety leads to significant increase of the antiparasitic and antitumoral activity. To get insight into the potential &amp;ldquo;dual&amp;rdquo; mechanism of antiparasitic action emerging from the presence of Ru(II) and CTZ in a single molecule, the inhibitory effect of this new complex on the biosynthesis of T. cruzi sterols of membrane and the interaction with DNA were studied. Although the tested complex does not affect DNA, it affects the T. cruzi biosynthetic pathway of conversion of squalene to squalene oxide. According to the results reported here, [RuCp(PPh3)2(CTZ)][CF3SO3] could be considered a prospective antiparasitic and/or antitumoral agent that deserves further evaluation</text>
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                <text>In this report, we studied the structural, microstructural and compositional trends in a manganite-polymethylmethacrilate (LSMO-PMMA) nanocomposite prepared by a sonochemical method focusing in the study of its interphase and its correlation with magnetotransport. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Raman scattering and X-ray powder diffraction (XRPD) studies showed evidence of PMMA reactivity with partial decomposition at the LSMO nanoparticles interface. Additionally, grazing incidence small angle X-ray scattering (GISAXS) and high resolution transmission electron microscopy (HRTEM) showed information about the microstructure and the separation between nanoparticles in these nanocomposite materials. An enhancement in the low field magnetoresistance (LFMR) respect to pure LSMO was observed for a 20% weight fraction addition of PMMA in the high temperature regime (205&amp;ndash;305 K) probably due to the increase in the magnetic disorder at the grain boundaries caused by the ultrasonic treatment. Nevertheless, lower PMMA weight fraction addition showed no enhancement in LFMR respect to pure LSMO, probably in agreement with the higher decomposition rate observed at the interphase.</text>
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                <text>&lt;strong&gt;Tumelero, Milton A.&lt;/strong&gt;</text>
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                <text>Journal of Magnetism and Magnetic Materials v. 382, 2015. -- p. 342-348</text>
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&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>This report describes the high yield biotransformation of 1,8-cineole by the strain Gymnopilus spectabilis 7423, a common fungus isolated from the Eucalyptus tree. The biotransformation was conducted under resting cell conditions and different parameters were tested in order to achieve up to 90% bioconversion. Only two regioisomers were detected, and they were identified as 3-&amp;alpha;-hydroxy-1,8-cineole and 2-&amp;alpha;-hydroxy-1,8- cineole obtained in a 82:8 ratio.</text>
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                <text>Biocatalysis v. 1, no. 1, 2015.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The coloration in citrus and other plants is&lt;br /&gt;due the accumulation of carotenoids, which are&lt;br /&gt;isoprenoid pigments of 40 carbon atoms (C40)&lt;br /&gt;and its derivatives. The enzymatic function of&lt;br /&gt;CCD4a has been associated previously with the&lt;br /&gt;metabolism of carotenoids in Chrysanthemum&lt;br /&gt;morifolium [1]. The flowers with white petals&lt;br /&gt;showed a high expression of CCD4a in contrast&lt;br /&gt;with those with yellow petals that showed a low&lt;br /&gt;expression. The interpretation was that the&lt;br /&gt;synthetized carotenoids are degraded by CCD4a&lt;br /&gt;to produce colorless petals [1]. In saffron stigmas&lt;br /&gt;(Crocus sativus) CCD4a and CCD4b were&lt;br /&gt;associated with the transformation of zeaxanthin&lt;br /&gt;in the apocarotenoids responsible by the color,&lt;br /&gt;taste and aroma of this so appreciated spice</text>
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                <text>Revista Processos Qu&amp;iacute;micos v. 9, no. 18, 2015. -- p. 163-165</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Various cutaneous glands have been identified as sources of chemical signals that mediate many social interactions in deer. The pampas deer, a species considered near threatened, inhabits grasslands of South America. In this work, the chemical compositions from preorbital, tarsal, and digital gland secretions of semi-captive males were characterized by gas chromatography&amp;ndash;mass spectrometry. The composition of these secretions showed a great complexity, with 143 compounds detected. Hierarchical cluster and principal component analyses show no relation to age or secretion type. Five compound classes (esters, fatty alcohols, lactones, sterols, and sulphuretted) differed with glands. The chemical complexity of the secretions, the individual differences in the whole compounds composition, and the absence of clustering by age lead to the hypothesis that these secretions may encode at once for individual information and for social status information.&lt;br /&gt;&lt;br /&gt;Varias gl&amp;aacute;ndulas cut&amp;aacute;neas han sido identificadas como productoras de se&amp;ntilde;ales qu&amp;iacute;micas que median interacciones sociales en losciervos. El venado de las pampas es una especie considerada casi amenazada que habita los pastizales de Sudam&amp;eacute;rica. En este trabajo se caracteriz&amp;oacute; la composici&amp;oacute;n qu&amp;iacute;mica de las secreciones de las gl&amp;aacute;ndulas preorbital, tarsal e interdigital de machos por cromatograf&amp;iacute;a de gases-espectrometr&amp;iacute;a de masas. Estas secreciones mostraron una gran complejidad en su composici&amp;oacute;n, con 143 compuestos detectados. No se observ&amp;oacute; ninguna agrupaci&amp;oacute;n de compuestos relacionada con la edad o el tipo de secreci&amp;oacute;n. Cinco clases de compuestos (&amp;eacute;steres, alcoholes grasos, lactonas, esteroles, y compuestos azufrados) difirieron de acuerdo al origen glandular. La complejidad qu&amp;iacute;mica de las secreciones, las diferencias individuales en dicha composici&amp;oacute;n, y la ausencia de agrupamiento por edad, llevan a postular la hip&amp;oacute;tesis de que estas secreciones pueden codificar a la vez tanto informaci&amp;oacute;n individual como del estado social.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>Journal of Mammalogy v. 97, no. 1, 2016.-- p. 167-168</text>
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                <text>Single domain heavychain binders (nanobodies) obtained from camelid antibody libraries hold a great promise for immunoassay development. However, there is no simple method to select the most valuable nanobodies from the crowd of positive clones obtained after the initial screening. In this paper, we describe a novel nanobody-based platform that allows comparison of the reactivity of hundreds of clones with the labeled antigen, and identifies the best nanobody pairs for two-site immunoassay development. The output clones are biotinylated in vivo in 96-well culture blocks and then used to saturate the biotin binding capacity of avidin coated wells. This standardizes the amount of captured antibody allowing their sorting by ranking their reactivity with the labeled antigen. Using human soluble epoxide hydrolase (sEH) as a model antigen, we were able to classify 96 clones in four families and confirm this classification by sequencing. This provided a criterion to select a restricted panel of five capturing antibodies and to test each of them against the rest of the 96 clones. The method constitutes a powerful tool for epitope binning, and in our case allowed development of a sandwich ELISA for sEH with a detection limit of 63 pg/mL and four log dynamic range, which performed with excellent recovery in different tissue extracts. This strategy provides a systematic way to test nanobody pairwise combinations and would have a broad utility for the development of highly sensitive sandwich immunoassays.</text>
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                <text>&lt;strong&gt;Streamlined method for parallel identification of single domain antibodies to membrane receptors on whole cells&lt;/strong&gt;</text>
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                <text>Background&lt;br /&gt;&lt;br /&gt;Owing to their minimal size, high production yield, versatility and robustness, the recombinant variable domains (nanobodies) of camelid single chain antibodies are valued affinity reagents for research, diagnostic, and therapeutic applications. While their preparation against purified antigens is straightforward, the generation of nanobodies to difficult targets such as multi-pass or complex membrane cell receptors remains challenging. Here we devised a platform for high throughput identification of nanobodies to cell receptor based on the use of a biotin handle.&lt;br /&gt;Methods&lt;br /&gt;&lt;br /&gt;Using a biotin-acceptor peptide tag, the in vivo biotinylation of nanobodies in 96 well culture blocks was optimized allowing their parallel analysis by flow cytometry and ELISA, and their direct use for pull-down/MS target identification.&lt;br /&gt;Results&lt;br /&gt;&lt;br /&gt;The potential of this strategy was demonstrated by the selection and characterization of panels of nanobodies to Mac-1 (CD11b/CD18), MHC II and the mouse Ly-5 leukocyte common antigen (CD45) receptors, from a VHH library obtained from a llama immunized with mouse bone marrow derived dendritic cells. By on and off switching of the addition of biotin, the method also allowed the epitope binning of the selected Nbs directly on cells.&lt;br /&gt;Conclusions&lt;br /&gt;&lt;br /&gt;This strategy streamlines the selection of potent nanobodies to complex antigens, and the selected nanobodies constitute ready-to-use biotinylated reagents.&lt;br /&gt;General significance&lt;br /&gt;&lt;br /&gt;This method will accelerate the discovery of nanobodies to cell membrane receptors which comprise the largest group of drug and analytical targets.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>&lt;strong&gt;Rossotti, Mart&amp;iacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Tabares, Sof&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Alfaya, Luc&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Leizagoyen, Carmen&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Moron, Gabriel&lt;/strong&gt;</text>
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                <text>Biochimica et Biophysica Acta v. 1850, no. 7, 2015. -- p. 1397-1404</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Bonding and singlet&amp;ndash;triplet gap of silicon trime : Effects of protonation and attachment of alkali metal cations&lt;/strong&gt;</text>
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                <text>We revisit the singlet&amp;ndash;triplet energy gap (&amp;Delta;EST) of silicon trimer and evaluate the gaps of its derivatives by attachment of a cation (H+, Li+, Na+, and K+) using the wavefunction-based methods including the composite G4, coupled-cluster theory CCSD(T)/CBS, CCSDT and CCSDTQ, and CASSCF/CASPT2 (for Si3) computations. Both 1A1 and 3 inline image states of Si3 are determined to be degenerate. An intersystem crossing between both states appears to be possible at a point having an apex bond angle of around &amp;alpha;&amp;thinsp;=&amp;thinsp;68&amp;thinsp;&amp;plusmn;&amp;thinsp;2&amp;deg; which is 16&amp;thinsp;&amp;plusmn;&amp;thinsp;4 kJ/mol above the ground state. The proton, Li+ and Na+ cations tend to favor the low-spin state, whereas the K+ cation favors the high-spin state. However, they do not modify significantly the &amp;Delta;EST. The proton affinity of silicon trimer is determined as PA(Si3)&amp;thinsp;=&amp;thinsp;830&amp;thinsp;&amp;plusmn;&amp;thinsp;4 kJ/mol at 298 K. The metal cation affinities are also predicted to be LiCA(Si3)&amp;thinsp;=&amp;thinsp;108&amp;thinsp;&amp;plusmn;&amp;thinsp;8 kJ/mol, NaCA(Si3)&amp;thinsp;=&amp;thinsp;79&amp;thinsp;&amp;plusmn;&amp;thinsp;8 kJ/mol and KCA(Si3)&amp;thinsp;=&amp;thinsp;44&amp;thinsp;&amp;plusmn;&amp;thinsp;8 kJ/mol. The chemical bonding is probed using the electron localization function, and ring current analyses show that the singlet three-membered ring Si3 is, at most, nonaromatic. Attachment of the proton and Li+ cation renders it anti-aromatic. &amp;copy; 2015 Wiley Periodicals, Inc.</text>
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                <text>The effects of partial replacement of chromium by molybdenum was studied on the structure and electrochemical kinetic properties of ZrCr1-xNiMox(x = 0.0, 0.3 and 0.6) metal hydride alloys. The arc-melting prepared alloys were metallurgically characterized by X-ray diffraction and energy dispersive spectroscopy microanalysis, which showed AB2 (with hexagonal C14 structure) and ZrxNiy (Zr7Ni10, Zr9Ni11) phases. After a partial substitution of chromium by molybdenum, secondary phases monotonically increase with the C14 unit cell volume indicating that most of molybdenum atoms locate in the B-site.&lt;br /&gt;&lt;br /&gt;The alloys were electrochemically characterized using charge/discharge cycling, electrochemical impedance spectroscopy and rate capability experiments that allowed the determination of hydriding reaction kinetic parameters. The presence of molybdenum produces a positive effect for hydrogen diffusion in the alloy lattice, and ZrCr0.7NiMo0.3 alloy depicts the better kinetics associated with a fast activation, lower charge transfer resistance and the best high rate discharge behavior. This fact would be related to a lower diffusion time constant and a bigger value of the product between exchange density current and surface active area. There is a trade-off in the amounts of secondary phase and Laves phases in order to improve the kinetic performance.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>Investigaci&amp;oacute;n virtual de sistemas bioinorg&amp;aacute;nicos: Una herramienta para la ense&amp;ntilde;anza de la Qu&amp;iacute;mica / Mar&amp;iacute;a H. Torre, ed. Saarbr&amp;uuml;cken : Editorial Acad&amp;eacute;mica Espa&amp;ntilde;ola, 2015 p. 1-8</text>
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                <text>Sixteen healthy volunteers (8 women and 8 men) participated in a 2-period, 2-treatment crossover study. A delayed-release gastroresistant formulation of ketoprofen was administered under fasting and fed conditions. Cmax, AUC, Cmax/AUC, and kel obtained after food coadministration did not differ from those calculated under fasting administration. Ninety-five percent confidence intervals for fed/fasting geometric mean ratio of Cmax/AUC and AUC were 0.80&amp;ndash;1.14 and 0.80&amp;ndash;1.23, respectively. A significant difference (P &amp;lt; .01) was found between lag-time medians (T0), with a longer T0 after food intake (5.5 vs 2.5 hours). Also, a significant difference between the medians of Tmax was found (P &amp;lt; .01), being 7.0 hours after food coadministration and 4.0 hours under fasting administration, but this difference disappeared once T0 was subtracted from Tmax. Cmax/AUC, which is related to drug absorption rate, showed significant differences between sexes. Men showed higher (P&amp;thinsp;=.006) Cmax/AUC means (0.468&amp;thinsp;&amp;plusmn;&amp;thinsp;0.094 vs 0.361&amp;thinsp;&amp;plusmn;&amp;thinsp;0.087 h&amp;minus;1. Tmax was also significantly different (P &amp;lt; .05), being 4.0 (3.0&amp;ndash;5.0) hours for men and 8.0 (5.0&amp;ndash;10.0) hours for women. In conclusion, men showed a faster intestinal absorption rate with earlier time-to-peak plasma concentration of ketoprofen. Food coadministration extended the gastric residence time of formulation but exerted no effect on its intestinal absorption pattern.</text>
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                <text>Clinical Pharmacology in Drug Development&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; 2015. -- 5 p.</text>
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                <text>Background and Objectives Ketoprofen, a potent nonsteroidal anti-inflammatory drug, is clinically administered as a racemic mixture. One of the possible metabolism routes of ketoprofen is the inversion of the R- to S-enantiomer in the gastrointestinal tract. Ketoprofen, as a weak acid drug, might undergo recirculation through pancreatic/intestinal juices. The aim of the work was to investigate if a plasma-gastrointestinal tract recirculation of ketoprofen could explain its R-to-S chiral inversion after the oral administration of two modified-release formulations: a gastro-resistant delayed-release tablet (Reference) and an extended-release-plus-immediate-release bilayer tablet (Test). Methods Sixteen healthy Caucasian volunteers (eight women and eight men) participated in a ketoprofen bioequivalence study. Both formulations were administered with and without food. In both cases, standard meals were given throughout the experiment. R- and S-enantiomers were measured separately using a validated HPLC&amp;ndash;UV chiral method. Mean concentration&amp;ndash;time profiles of ketoprofen enantiomers in plasma were obtained for men and women. Area under the plasma concentration&amp;ndash;time curve, maximum ketoprofen plasma concentration, and time-to-peak were also computed for both isomers, both modes of administration, and both sexes. S/R concentration ratio was assessed as an indicator of enantiomer chiral inversion rate. Results Differences in the pharmacokinetics of S- and R-ketoprofen enantiomers were found after the Test administration. S-Ketoprofen presented a lower plasma exposure compared to R-enantiomer. However, the S/R concentration ratio increased 1 h (in men) and 2 h (in women) after meal intakes. This was related to pancreatic and/or intestinal and/or biliary secretions of the drug, followed by reabsorption and conversion of the R- to the S-isomer. The lower intestinal pH reported for men would lead to a higher oral bioavailability of the Test formulation and a higher reabsorption of both ketoprofen isomers in this sex. Hence, a higher rise of the S/R concentration ratio could be observed in men. No significant differences between isomers exposure were detected in both sexes after the Reference administration. Different lag times were observed after fed and fasting administration of this formulation; however, drug absorption coincided with food ingestion. Then, drug recirculation affected the S/R ratio from the beginning of drug exposure, minimizing the difference between isomers disposition. Conclusions R-to-S conversion rate could be mainly associated with several passages of the drug through the intestinal mucosa. The concentration&amp;ndash;time profiles of ketoprofen in plasma after the administration of both formulations evidenced R-to-S conversion of recirculating drug following meal intakes.</text>
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                <text>&lt;strong&gt;Lorier, Marianela&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Magallanes, Laura&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ibarra, Manuel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Guevara, Natalia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;V&amp;aacute;zquez, Marta&lt;/strong&gt;</text>
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                <text>European Journal of Drug Metabolism and Pharmacokinetics 2015. -- 7 p.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>DOI: 10.1007/s13318-015-0313-2</text>
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                <text>&lt;strong&gt;Secondary-peak profile of methadone in saliva after administration of multiple doses in patients with chronic pain&lt;/strong&gt;</text>
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                <text>OPIOIDES</text>
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                <text>&lt;strong&gt;V&amp;aacute;zquez, Marta&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Lorier, Marianela&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Montes, Mar&amp;iacute;a Jos&amp;eacute;&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Retamoso, Irene&lt;/strong&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Current Topics in Pharmacology v. 19, 2015. -- p. 21-26</text>
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                <text>Research Trends</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>This chapter presents a review of the scientific literature concerning the determination of the mineral contents of edible fats and oils. The search was carried out by means of the Scopus and Google Scholar internet search engines without publishing date restrictions, and produced 84 references comprising book chapters and journal articles. Detection techniques and sample preparation are discussed in detail. As expected, the majority of the articles refer to the use of atomic spectrometric techniques such as atomic absorption and emission and plasma source mass spectrometry. Sample preparation techniques range from simple dilution in organic solvent to various wet-ashing approaches including microwave-assisted digestion and formation of emulsions and microemulsions, either batch-wise or by means of flow injection analysis. Dry ashing is also reported. Based on this review, it can be concluded that the determination of the mineral contents of edible oils and fats may be relevant from the technological and toxicological points of view but not from the nutritional one. It should also be noted that almost all the references report the determination of total element regardless of its speciation.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Cap&amp;iacute;tulo de Libro</text>
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                <text>ISBN: 978-3-659-07553-7</text>
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        <name>Agentes antitumorales</name>
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