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                <text>Serum copper levels in dairy cattle have been studied in eight locations throughout Department of Salto, in Uruguay. The overall incidence of hypocupraemia lies in 30% which is not homogeneously distributed since some farms are almost exempt from hypocupraemical individuals. Copper complexes with Cu(Phe)2, Cu(Gly)2.H2O and Cu(Val)2 were evaluated as injectable sources of supplemental Cu in the most hypocupraemic herd and Cu(Phe)2 proved to be the best at improving Cu status. The efficacy of Cu(Phe)2 was tested in a further hypocupraemic herd, showing that the treated cattle maintained the serum copper level at an adequate level for at least 100 days. At the same time, analyses of copper, molybdenum, sulphur and phosphorous levels in grass were done along the year. Our results show that the copper content in grass was under adequate levels most part of the year, and the deficiency was more critical in autumn. Although the molybdenum and sulphur levels were low enough not to expect them to interfere in copper absorption, the Mo content may be enhancing the copper deficiency.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>The aim of this study is to evaluate the possible incidence in the dosage adjustment of Theophylline. An in vivo study was carried out with 6 healthy volunteers after the administration of an infusion of "mate herb" for a period of 7 days. Plasma Theophilline and Caffeine levels were analysed by high performance liquid chromatography (HLPC) |b revealing the formation of Theophylline as a metabolism product of Caffeine. The analysis of the infusion showed presence of Caffeine and Theobromine |b but not Theophylline. After 7 days of administration the Theophylline concentration oscillated between 0.62 and 1.59 ug/ml for the different individuals; these values can be increased with concomitant intake of other beverages containing xanthines.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Este art&amp;iacute;culo presenta reflexiones sobre la experiencia de trabajo de la red conformada por la Universidad Nacional de Tierra del Fuego, Ant&amp;aacute;rtida e Islas del Atl&amp;aacute;ntico Sur de Argentina y el Grupo de Educaci&amp;oacute;n Ambiental de la Red Tem&amp;aacute;tica de Medio Ambiente de UdelaR, en el marco del programa: &amp;ldquo;N&amp;uacute;cleo de Estudios e Investigaci&amp;oacute;n en Educaci&amp;oacute;n Superior del MERCOSUR (NEIES-MERCOSUR)&amp;rdquo;. El proyecto apunta a repensar el papel de las universidades del MERCOSUR ante la actual crisis ambiental, en el cruce problem&amp;aacute;tico entre los procesos de globalizaci&amp;oacute;n y el desarrollo sustentable. El objetivo general es poder comprender las relaciones entre los procesos de configuraci&amp;oacute;n de la epistemolog&amp;iacute;a ambiental y la educaci&amp;oacute;n ambiental, los enfoques metodol&amp;oacute;gicos y los dise&amp;ntilde;os curriculares, en ambas instituciones. En el desarrollo de este escrito se exponen referencias al proceso de institucionalizaci&amp;oacute;n de la educaci&amp;oacute;n ambiental en la Educaci&amp;oacute;n Superior de la Rep&amp;uacute;blica Argentina y en la Rep&amp;uacute;blica del Uruguay, enmarcado en el contexto de reflexi&amp;oacute;n de la educaci&amp;oacute;n universitaria en el MERCOSUR. Luego se exponen reflexiones sobre la conformaci&amp;oacute;n de la red y los diversos intercambios y movilidades efectuadas. Finalmente se hace hincapi&amp;eacute; en la experiencia colaborativa del trabajo en red que apunta a la visi&amp;oacute;n de interdisciplina puesta en juego. Estamos interesados en contextualizar la reflexi&amp;oacute;n sobre nuestras pr&amp;aacute;cticas en un proceso de integraci&amp;oacute;n creciente a nivel de la Educaci&amp;oacute;n Superior en el MERCOSUR, en este caso espec&amp;iacute;fico, referido a la educaci&amp;oacute;n ambiental.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>In spite of high plant growth regulator application rates, little has been reported in the literature on determination of their residues in fruits and vegetables. This would be useful in monitoring good manufacturing practices and overall safety through the enforcement of maximum residue levels (MRLs). The present work describes method validation for the determination of 1-naphthylacetic acid (NAA) and 2(1-naphthyl)acetamide (NAAm) in tomato and zucchini using the mini-Luke, ethyl acetate (EtOAc) and acetate-buffered quick, easy, cheap, effective, rugged, and safe (QuEChERS) methods. Samples were spiked at two different levels: 50 and 100 &amp;mu;g/kg for NAA and 20 and 100 &amp;mu;g/kg for NAAm. These compounds were analyzed within the same chromatographic run with LC coupled to triple quadrupole MS (LC/(QqQ)MS/MS) in positive and negative electrospray ionization [ESI(+) and ESI(&amp;ndash;)] modes for NAAm and NAA, respectively. For analyte confirmation, LC/ESI(-)QTOF-MS was also investigated given that NAA has only one multiple reaction monitoring transition (185.1&amp;rarr;140.9 m/z). These three common methods were used to determine linearity, recoveries, precision (RSD), matrix effects, repeatability, and reproducibility (n = 5) for the selected matrixes. In terms of the Directorate-General for Health and Consumers (DG-SANCO) guidelines, only insignificant differences were found for the multiresidue methods tested, regardless of the commodity. Matrix-matched calibration was used, and LODs were below 10.1 &amp;mu;g/kg for NAA and 6.0 &amp;mu;g/kg for NAAm, which were lower than the MRLs established in current European Union legislation for these compounds. Obtained recoveries for NAA ranged from 87 to 107% with RSD values below 10% for mini-Luke, 83 to 107% with RSD 0.996) for all methods used. Good repeatability and reproducibility in terms of RSD were obtained (11.3&amp;ndash;17.8%) for these analytical methods. The results were acceptable within the studied ranges for both analytes in all methods. As these multiresidue methods are used at the present time in many laboratories, this survey indicates that these analytes should be included in their monitoring scope.</text>
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                <text>&lt;strong&gt;Incorporation of Caprylic Acid into a Single Cell Oil Rich in Docosahexaenoic Acid for the Production of Specialty Lipids&lt;/strong&gt;</text>
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                <text>LIPIDOS&#13;
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                <text>Research background. New sources of docosahexaenoic acid have recently been investigated aiming at infant formula fortification and dietary supplementation, among which the single cell oil with 40&amp;ndash;50 % of this acid. Experimental approach. For this purpose, such an oil was blended with caprylic acid in amount substance ratio ranging from 1:1 to 5:1 and the blends were interesterified using either Novozym 435 or Lipozyme TL IM as the catalyst. The influence of the amount of excess free caprylic acid in the substrate, as well as the type of enzyme on the triacylglycerol rearrangement resulting from the synthesis of the structured lipids were evaluated. Results and conclusions. The regiospecific lipase Lipozyme TL IM seemed to induce transesterification among single cell oil triacylglycerols preferably by acidolysis with caprylic acid, which was directly proportional to the ratio of this acid in the substrate. In reactions catalyzed by the non-regiospecific lipase Novozym 435, a higher incorporation of caprylic acid into single cell oil triacylglycerols was observed than when using Lipozyme TL IM, independently of the oil/caprylic acid molar ratio. Novelty and scientific contribution. These results revealed the importance of combining the choice of the type of lipase, either regiospecific or not, with the amount ratios of free fatty acids and the substrate in acidolysis when aiming to produce structured lipids as a source of docosahexaenoic acid.&#13;
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                <text>&lt;strong&gt;Kanno Mathias, Daniela&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Piazentin Costa, Jacqueline&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rodrigues Calvo, Carolina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Claro Da Silva, Roberta&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Converti, Attilio&lt;/strong&gt;</text>
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                <text>Food Technology &amp;amp; Biotechnology v. 58, no 4, 2020.-- p. 411-422&#13;
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                <text>University of Zagreb, Faculty of Food Technology and Biotechnology&#13;
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor &lt;/strong&gt;sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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        <name>Acido Caprilico</name>
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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Increased flavour diversity of Chardonnay wines by spontaneous fermentation and co-fermentation with Hanseniaspora vineae&lt;/strong&gt;</text>
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                <text>VINOS</text>
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                <text>FERMENTACION</text>
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                <text>Discovery, characterisation and use of novel yeast strains for winemaking is increasingly regarded as a way for improving quality and to provide variation, including subtle characteristic differences in fine wines. The objective of this work was to evaluate the use of a native apiculate strain, selected from grapes, Hanseniaspora vineae (H. vineae) 02/5A. Fermentations were done in triplicate, working with 225 L oak barrels, using a Chardonnay grape must. Three yeast fermentation strategies were compared: conventional inoculation with a commercial Saccharomyces cerevisiae strain, ALG 804, sequential inoculation with H. vineae and then strain ALG 804 and spontaneous fermentation. Yeast strain identification was performed during fermentation, in which the apiculate strain was found to be active, until 9% of alcohol in volume, for the co-fermentation and the spontaneous fermentation was completed by three native S. cerevisiae strains. Basic winemaking parameters and some key chemical analysis, such as concentration of glycerol, biogenic amines, organic acids, and aroma compounds were analysed. Sensory analysis was done using a trained panel and further evaluated with professional winemakers. Sequential inoculation with H. vineae followed by S. cerevisiae resulted in relatively dry wines, with increased aroma and flavour diversity compared with wines resulting from inoculation with S. cerevisiae alone. Wines produced from sequential inoculations were considered, by a winemaker&amp;rsquo;s panel, to have an increased palate length and body. Characteristics of wines derived from sequential inoculation could be explained due to significant increases in glycerol and acetyl and ethyl ester flavour compounds and relative decreases in alcohols and fatty acids. Aroma sensory analysis of wine character and flavour, attributed to winemaking using H. vineae, indicated a significant increase in fruit intensity described as banana, pear, apple, citric fruits and guava. GC analysis of the relative accumulation of 23 compounds to significantly different concentrations for the three fermentation strategies is discussed in relation to aroma compound composition</text>
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                <text>&lt;strong&gt;Medina, Karina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gioia, O.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gomez, M. E.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Barquet, M.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gaggero de Munno, Carina&lt;/strong&gt;</text>
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                <text>Food Chemistry v. 141, 2013. -- p. 2513-2521</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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                <text>In this study, several approaches were tested to optimise the production and recovery of the widely used anticancer drug Taxol&amp;reg; (paclitaxel) from culturable vascular stem cells (VSCs) of Taxus baccata, which is currently used as a suc‑ cessful cell line for paclitaxel production. An in situ product recovery (ISPR) technique was employed, which involved combining three commercial macro-porous resin beads (HP-20, XAD7HP and HP-2MG) with batch and semi-continu‑ ous cultivations of the T. baccata VSCs after adding methyl jasmonate (Me-JA) as an elicitor. The optimal resin combi‑ nation resulted in 234&amp;plusmn;23 mg of paclitaxel per kg of fresh-weight cells, indicating a 13-fold improved yield compared to the control (with no resins) in batch cultivation. This resin treatment was further studied to evaluate the resins&amp;rsquo; removal capacity of reactive oxygen species (ROS), which can cause poor cell growth or reduce product synthesis. It was observed that the ISPR cultivations had fourfold less intracellular ROS concentration than that of the control; thus, a reduced ROS concentration established by the resin contributed to increased paclitaxel yield, contrary to previous studies. These paclitaxel yields are the highest reported to date using VSCs, and this scalable production method could be applied for a diverse range of similar compounds utilising plant cell culture.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Recombinant single domain antibodies (nanobodies) constitute an attractive alternative for the production of neutralizing therapeutic agents. Their small size warrants rapid bioavailability and fast penetration to sites of toxin uptake, but also rapid renal clearance, which negatively affects their performance. In this work, we present a new strategy to drastically improve the neutralizing potency of single domain antibodies based on their fusion to a second nanobody specific for the complement receptor CD11b/CD18 (Mac-1). These bispecific antibodies retain a small size (~30 kDa), but acquire effector functions that promote the elimination of the toxin-immunocomplexes. The principle was demonstrated in a mouse model of lethal toxicity with tetanus toxin. Three anti-tetanus toxin nanobodies were selected and characterized in terms of overlapping epitopes and inhibition of toxin binding to neuron gangliosides. Bispecific constructs of the most promising monodomain antibodies were built using anti Mac-1, CD45 and MHC II nanobodies. When co-administered with the toxin, all bispecific antibodies showed higher toxin-neutralizing capacity than the monomeric ones, but only their fusion to the anti-endocytic receptor Mac-1 nanobody allowed the mice to survive a 10-fold lethal dose. In a model of delayed neutralization of the toxin, the anti- Mac-1 bispecific antibodies outperformed a sheep anti-toxin polyclonal IgG that had shown similar neutralization potency in the co-administration experiments. This strategy should have widespread application in the development of nanobody-based neutralizing therapeutics, which can be produced economically and more safely than conventional antisera.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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                <text>El objetivo de este trabajo es estudiar el comportamiento diferencial de dos indicadores de rendimiento acad&amp;eacute;mico mediante modelos de regresi&amp;oacute;n lineal multivariante: el indicador tradicional &amp;ndash;promedio de calificaciones&amp;ndash; y un indicador novedoso &amp;ndash;el avance en la carrera&amp;ndash; definido como la raz&amp;oacute;n entre los cr&amp;eacute;ditos acumulados por el alumno durante cierto per&amp;iacute;odo de tiempo y los cr&amp;eacute;ditos que te&amp;oacute;ricamente debi&amp;oacute; acumular en dicho per&amp;iacute;odo de acuerdo con el plan de estudios programado. Se trata de una investigaci&amp;oacute;n correlacional, de corte transversal, de variables no manipuladas experimentalmente. Participaron 587 estudiantes matriculados en carreras de Qu&amp;iacute;mica de la Universidad de la Rep&amp;uacute;blica (UdelaR) durante 2000-2003, con al menos una asignatura aprobada durante el per&amp;iacute;odo comprendido entre marzo de 2003 y marzo de 2005. El grupo de participantes fue dividido aleatoriamente en dos muestras: estimaci&amp;oacute;n &amp;ndash;se construyeron los modelos de regresi&amp;oacute;n lineal incluyendo an&amp;aacute;lisis de interacciones y diagn&amp;oacute;stico de anomal&amp;iacute;as&amp;ndash; y validaci&amp;oacute;n &amp;ndash;los modelos fueron validados mediante contrastes de hip&amp;oacute;tesis de igualdad de par&amp;aacute;metros. Los factores explicativos considerados fueron el rendimiento previo, las metas acad&amp;eacute;micas de los estudiantes, la percepci&amp;oacute;n de su propia capacidad y variables sociodemogr&amp;aacute;ficas. Los dos indicadores est&amp;aacute;n notablemente correlacionados entre s&amp;iacute; (r=0,615, p&amp;lt;0,001) y ninguno correlaciona significativamente con las metas de resultado (promedio, p=0,612; avance, p=0,358). Los modelos multivariantes fueron satisfactoriamente validados y muestran que los indicadores se ven igualmente afectados por el rendimiento previo, que result&amp;oacute; la variable dominante (promedio, p=0,493, p&amp;lt;0,001; avance, p=0,484, p&amp;lt;0,001). Se diferencian en que el promedio adem&amp;aacute;s resulta afectado por la capacidad percibida (p=0,175, p&amp;lt;0,001) y, de manera indirecta, por las metas de aprendizaje (p=0,16, p&amp;lt;0,05, controlando por capacidad percibida). El comportamiento de ambos indicadores es similar, siendo los estudiantes que obtienen las peores calificaciones los m&amp;aacute;s susceptibles de presentar retraso curricular. Hay una dominancia del rendimiento previo como predictor de ambas formas de rendimiento futuro.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>One hundred twenty-five yeast strains isolated from table grapes and apples were evaluated for the control Botrytis cinerea of in vitro and in vivo. Ten strains were selected for their ability to inhibit mycelial growth of B. cinerea in vitro. In the in vivo assays, these yeasts were tested at 20 ◦C on &amp;lsquo;Thompson Seedless&amp;rsquo; berries for 7 days; only three were selected (m11, me99 and ca80) because they significantly reduced the incidence of gray mold. These three yeast strains were then evaluated at different concentrations (1 &amp;times; 107 , 1 &amp;times; 108 and 1 &amp;times; 109 cells mL&amp;minus;1 ) on &amp;lsquo;Thompson Seedless&amp;rsquo; grape berries at 20 ◦C. The strains m11, me99 and ca80 reduced the incidence of B. cinerea to 11.9, 26.1 and 32.1%, respectively, when the berries were submerged in a yeast suspension at a concentration of 1 &amp;times; 109 cells mL&amp;minus;1 24 h before inoculation with B. cinerea. The most favorable pH for antifungal activity was 4.6 in the three isolates. The three yeast strains secreted the hydrolytic enzymes chitinase and &amp;beta;-1-glucanase, and two strains (me99 and ca80) produced siderophores. The three yeast strains exhibited low oxidative stress tolerance and only strain m11 had the ability to produce biofilms. The strains were identified using 5.8S-ITS rDNA PCR-RFLP and correspond to the Meyerozyma guilliermondii (m11) and Aureobasidium pullulans (me99 and ca80) species.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Induction of antigen-specific tolerance by nanobody&amp;ndash;antigen adducts that target class-II major histocompatibility complexes&lt;/strong&gt;</text>
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                <text>&lt;p&gt;The association of autoimmune diseases with particular allellic products of the class-II major histocompatibility complex&lt;br /&gt;(MHCII) region implicates the presentation of the offending self-antigens to T cells. Because antigen-presenting cells are&lt;br /&gt;tolerogenic when they encounter an antigen under non-inflammatory conditions, the manipulation of antigen presentation may induce antigen-specific tolerance. Here, we show that, in mouse models of experimental autoimmune encephalomyelitis, type 1 diabetes and rheumatoid arthritis, the systemic administration of a single dose of nanobodies that recognize MHCII molecules and conjugated to the relevant self-antigen under non-inflammatory conditions confers long-lasting protection against these diseases. Moreover, co-administration of a nanobody&amp;ndash;antigen adduct and the glucocorticoid dexamethasone, conjugated to the&amp;nbsp;nanobody via a cleavable linker, halted the progression of established experimental autoimmune encephalomyelitis in symptomatic mice and alleviated their symptoms. This approach may represent a means of treating autoimmune conditions.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Pishesha, Novalia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Harmand, Thibault&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Smeding, Liyan Y.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ma, Weiyi&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ludwing, Leif S.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Janssen, Robine&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Xie, Yushu J.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;McCaul, Nicholas&lt;/strong&gt;</text>
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                <text>&lt;a href="https://exportcvuy.anii.org.uy/cvsni/?urlId=0714ab9cf73af9870ec8809b325b44115e7a8c32a7bffc5b0260762ba5347b07fa4dc1efff263fa6245889f68b031f22fc09f7dd37fb84c74004165d1dca6005&amp;amp;convocatoria=21&amp;amp;formato=html" target="_blank"&gt;&lt;strong&gt;Rossoti, Martin A.&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Nature Biomedical Engineering, 2021.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>Art&amp;iacute;culo</text>
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                <text>&lt;span id="docs-internal-guid-80b53838-7fff-331c-3ee1-4cf13e92c83e"&gt;&lt;span&gt;10.1038/s41551-021-00738-5&amp;nbsp; &lt;/span&gt;&lt;/span&gt;</text>
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                  <text>Bibliografía Nacional Química</text>
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                <text>&lt;strong&gt;Induction of protective immunity against murine secondary hydatidosis.&lt;/strong&gt;</text>
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                <text>Significant protective immunity against secondary hydatidosis in mice was achieved by immunization with a preparation of surface molecules of E. granulosus protoscoleces with Freund's incomplete adjuvant (PSEx-IFA). Study of PSEx-IFA immunogenicity demonstrates that glucidic epitopes evoke mainly IgM responses while peptidic epitopes evoke mainly IgG responses; however both types of epitopes elicit both types of responses. Analysis of the possible association between susceptibility or resistance to infection and antibody responses after challenge was also performed. Cyst fluid antigen (CFAg) specific antibody titres on month eight after challenge correlated with number and size of cysts. On the other hand no correlation was observed between protection and PSEx specific IgG titres either on the day of challenge or one month later. Nonetheless, immunoblot analysis revealed that some PSEx molecules were recognized on day 30 after challenge only by sera from immunized mice.</text>
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                <text>&lt;strong&gt;Hern&amp;aacute;ndez, A&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=9d36a9655c915bddd80b664491d73ec8"&gt;&lt;strong&gt;Nieto, Alberto&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Parasite Immunology v. 16, 1994. -- p. 537-544</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Inductive effect of methyl groups on acidopentaaminecobalt(III) complexes&lt;/strong&gt;</text>
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                <text>URUGUAY</text>
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                <text>Electron spectroscopy for chemical analysis (ESCA) was performed for [Co(NH3)5Cl](ClO4)2, trans-[Co(NH3)4(NH2CH3)Cl]- (ClO4)2, [Co(NH2CH3)5Cl](ClO4)2 and trans-[Co(NH3)4(NH2CH3)(OSO3)](ClO4) complexes. Comparison of the results for the complexes [Co(NH3)5Cl](ClO4)2 and trans-[Co(NH3)4(NH2CH3)Cl](ClO4)2 shows clearly the electronic influence (qI effect) of the methylamine group on the cobalt and through this on the chlorine atom in trans position. Comparison of [Co(NH2CH3)5Cl](ClO4)2 with trans-[Co(NH3)4(NH2CH3)Cl](ClO4)2 shows that methylation of the four cis-NH3 ligands does not produce a proportional decrease in the binding energy of the cobalt atom, while the electron density of the chloro ligand is not affected. For the complex trans- [Co(NH3)4(NH2CH3)(OSO3)](ClO4) theqI effect is almost completely compensated by the presence of the sulfato group in trans position. Acid dissociation constants are also reported for [Co(NH3)5(OH2)]3q and trans-[Co(NH3)4(NH2CH3)(OH2)]3q ions. The implications of these results for the mechanism of the acid and base hydrolysis reactions of acidopentaaminecobalt(III) complexes are discussed. The preparation of the trans-[Co(NH3)4(NH2CH3)(OSO3)](ClO4) complex through the trans-[Co(NH3)4(NH2CH3)(SO3)]q precursor is also described. q2000 All rights reserved.</text>
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                <text>&lt;strong&gt;Benzo, Fabian&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Beyer, Lothar&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Sienra, Beatriz&lt;/strong&gt;</text>
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                <text>Polyhedron v. 19, no. 8, 2000. -- p. 971-974</text>
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                <text>2000</text>
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            <name>Rights</name>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>&lt;strong&gt;Industrializaci&amp;oacute;n de naranjas, pomelos, mandarinas y limones : jugo concentrado, pectina, aceites esenciales.&amp;nbsp;&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;INDUSTRIALIZACION&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;AGRIOS&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;NARANJAS&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;POMELOS (FRUTAS)&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;MANDARINAS&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;LIMONES&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;ZUMOS DE FRUTAS&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;JUGOS CONCENTRADOS&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;PECTINA&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;ACEITES ASENCIALES&lt;/strong&gt;</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="472725">
                <text>Biblioteca-FQ</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>1981</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>Papel</text>
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                <text>PDF</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>Ingl&amp;eacute;s</text>
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              <elementText elementTextId="472730">
                <text>Espa&amp;ntilde;ol</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="472731">
                <text>Bibliograf&amp;iacute;a</text>
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          <element elementId="116">
            <name>Temporal Coverage</name>
            <description>Temporal characteristics of the resource.</description>
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                <text>1948-1981</text>
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        <name>Aceites esenciales</name>
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      <tag tagId="5306">
        <name>Agrios</name>
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      <tag tagId="4298">
        <name>Industrialización</name>
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      <tag tagId="5308">
        <name>Jugos concentrados</name>
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      <tag tagId="3512">
        <name>Limones</name>
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      <tag tagId="3089">
        <name>Mandarinas</name>
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        <name>Naranjas</name>
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      <tag tagId="5309">
        <name>Pectina</name>
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      <tag tagId="5307">
        <name>Pomelos (frutas)</name>
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      <tag tagId="432">
        <name>Zumos de frutas</name>
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                <name>Bit Depth</name>
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                    <text>8</text>
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                <name>Channels</name>
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                    <text>3</text>
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              <element elementId="73">
                <name>Height</name>
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                <name>Width</name>
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                    <text>150</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Bibliografía Nacional Química</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="709198">
                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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            <element elementId="37">
              <name>Contributor</name>
              <description>An entity responsible for making contributions to the resource</description>
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                <elementText elementTextId="709199">
                  <text>Departamento de Documentación y Biblioteca</text>
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                  <text>RIQUIM</text>
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      <name>Document</name>
      <description>A resource containing textual data.  Note that facsimiles or images of texts are still of the genre text.</description>
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        <element elementId="7">
          <name>Original Format</name>
          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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              <text>Papel</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>&lt;strong&gt;Industrializaci&amp;oacute;n en el Uruguay&lt;/strong&gt;</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="584162">
                <text>INDUSTRIALIZACION</text>
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              <elementText elementTextId="584163">
                <text>URUGUAY</text>
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              <elementText elementTextId="584164">
                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>1955</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>&lt;strong&gt;Cheol, J. P.&lt;/strong&gt;</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Anales de la Facultad de Qu&amp;iacute;mica y Farmacia (Uruguay) v. 4, 1955. -- p. 267-282</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="584168">
                <text>Facultad de Qu&amp;iacute;mica y Farmacia (Uruguay)</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>1955</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="584170">
                <text>&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt;&lt;br /&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt;&lt;br /&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="584171">
                <text>Papel</text>
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              <elementText elementTextId="584172">
                <text>PDF</text>
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          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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                <text>Espa&amp;ntilde;ol</text>
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          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="584174">
                <text>Art&amp;iacute;culo</text>
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            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Uruguay</text>
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        <name>1955</name>
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      <tag tagId="27">
        <name>Bibliografía Nacional Química</name>
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        <name>Industrialización</name>
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      <tag tagId="15">
        <name>Uruguay</name>
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