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                <text>The first experimental results about the growth and characterization of Pb1&amp;minus;xCdxTe new high-Z ternary alloy, grown by Vapour Phase Epitaxy (VPE) onto CdTe single crystal substrates are presented. SEM images have shown a well-defined interface between the substrate and the heterostructure bulk, without voids or inclusions. EDX analysis in a line scan mode was done over the layer crossections. The Te, Pb and Cd concentration profiles were found, verifying a strong inter-diffusion in the metallic sublattices and confirming the existence of the Pb1&amp;minus;xCdxTe ternary alloy. This has been also confirmed by X-ray diffraction measurements. For the longest growth times, two types of surface defects arose: PbTe aligned microcrystals and cylindrical-like Te-rich structures. Hall measurements showed that the carrier concentration of the layers decreases and the resistivity increases when the growth temperature increases. The influence of the surface defects on the electrical properties was also demonstrated.</text>
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                <text>&lt;strong&gt;Mucin-type O-glycosylation in Mesocestoides vogae (syn. corti)&lt;/strong&gt;</text>
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                <text>MESOCESTOIDES VOGAE</text>
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                <text>PARASITOLOGIA</text>
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                <text>2008</text>
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                <text>BIBLIOGRAF&amp;Iacute;A NACIONAL QU&amp;Iacute;MICA</text>
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                <text>Protein glycosylation is an important post-translational modification underlying host&amp;ndash;parasite interactions, which may determine the outcome of infection. Although Mesocestoides vogae represents an important model for investigating the various aspects of cestode biology, virtually no information is available about the structure and synthesis of glycans in this parasite. In this work, focused on the initiation pathway of mucin-type O-glycosylation in M. vogae, we characterized O-glycoproteins bearing the simple mucin-type cancer-associated Tn and sialyl-Tn antigens, and the expression and activity of ppGalNAc-T, the key enzyme responsible for the first step of mucin-type O-glycosylation. Using immunohistochemistry, Tn and sialyl-Tn antigens were detected mainly in the tegument (microtriches) and in parenchymal cells. Tn expression was also observed in lateral nerve cords. Both Tn and sialyl-Tn antigens were detected in in vitro cultured parasites. Based on their electrophoretic mobility, Tn- and sialyl-Tn-bearing glycoproteins from M. vogae were separated into several components of 22 to 60 kDa. The observation that Tn and sialyl-Tn glycoproteins remained in the 0.6 N perchloric acid-soluble fraction suggested that they could be good candidates for characterizing mucin-type glycosylation in this parasite. O-glycoproteins were purified and initially characterized using a proteomic approach. Immunohistochemical analysis of the tissue distribution of ppGalNAc-T revealed that this enzyme is expressed in the sub-tegumental region and in the parenchyma of the parasite. In M. vogae cultured in vitro, ppGalNAc-T was mainly detected in the suckers. Using a panel of 8 acceptor substrate synthetic peptides, we found that M. vogae ppGalNAc-T preferentially glycosylate threonine residues, the best substrates being peptides derived from human mucin MUC1 and from Trypanosoma cruzi mucin. These results suggest that M. vogae might represent a useful model to study O-glycosylation, and provide new research avenues for future studies on the glycopathobiology of helminth parasites.</text>
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                <text>&lt;strong&gt;Medeiros, Andrea&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Chiribao, M. L.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ubillos, Luis.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Festari, M. F.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Robello, C.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Calvete, Juan J&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Osinaga, Eduardo.&lt;/strong&gt;</text>
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                <text>International Journal for Parasitology v. 38, no. 3-4, 2008. -- p.265-276</text>
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                <text>Elsevier</text>
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                <text>2008</text>
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              <elementText elementTextId="441033">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>DOI: 10.1016/j.ijpara.2007.07.015</text>
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        <name>Mesocestoides vogae</name>
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                  <text>Bibliografía Nacional Química</text>
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                <text>&lt;strong&gt;Mucins shed from the laminated layer in Cystic Echinococcosis are captured by Kupffer cells via the lectin receptor clec4F&lt;/strong&gt;</text>
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                <text>ECHINOCOCCUS</text>
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                <text>MUCINAS</text>
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                <text>LECTINAS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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              <elementText elementTextId="681440">
                <text>2023</text>
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              <elementText elementTextId="681441">
                <text>Cystic echinococcosis is caused by the larval stages (hydatids) of ces tode parasites belonging to the species cluster Echinococcus granulosus sensu lato, with E. granulosus sensu stricto being the main infecting species. Hydatids are blad derlike structures that attain large sizes within various internal organs of livestock ungulates and humans. Hydatids are protected by the massive acellular laminated layer (LL), composed mainly of mucins. Parasite growth requires LL turnover, and abundant LL-derived particles are found at infection sites in infected humans, raising the question of how LL materials are dealt with by the hosts. In this article, we show that E. granulosus sensu stricto LL mucins injected into mice are taken up by Kupffer cells, the liver macrophages exposed to the vascular space. This uptake is largely de pendent on the intact mucin glycans and on Clec4F, a C-type lectin receptor which, in rodents, is selectively expressed in Kupffer cells. This uptake mechanism operates on mucins injected both in soluble form intravenously (i.v.) and in particulate form intraperitoneally (i.p.). In mice harboring intraperitoneal infections by the same spe cies, LL mucins were found essentially only at the infection site and in the liver, where they were taken up by Kupffer cells via Clec4F. Therefore, shed LL materials circulate in the host, and Kupffer cells can act as a sink for these materials, even when the parasite grows in sites other than the liver.</text>
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                <text>&lt;strong&gt;Barrios, Anabella A.&lt;/strong&gt;</text>
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              <elementText elementTextId="681443">
                <text>&lt;strong&gt;Mouhape, Camila&lt;/strong&gt;</text>
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              <elementText elementTextId="681444">
                <text>&lt;strong&gt;Schreiber, Leonard&lt;/strong&gt;</text>
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              <elementText elementTextId="681445">
                <text>&lt;strong&gt;Zhang, Linyun&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Nell, Juliane&lt;/strong&gt;</text>
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                <text>&lt;a href="https://export.cvuy.uy/cv/?149370b82e8bfaca31d675b393d71ba52fd2a41bcb25c6dfa2b61669f48f45a70560127121f59365b1b80ae6d9c065384c436810c825a22df4a5da81cdffa532" target="_blank"&gt;&lt;strong&gt;Su&amp;aacute;rez Martins, Mariana&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Schlapp, Geraldine&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Meikle, Mar&amp;iacute;a Noel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mulet, Ana Paula&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Hsu, Tsui Ling&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Hsieh, Shie Liang&lt;/strong&gt;</text>
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                <text>&lt;a href="https://export.cvuy.uy/cv/?8077d6141c1946a30df792835b6b6ef857fe8ef0419315625ad1c8238bb9aca6cff0e2e3a0117a509b98df7dc5fd1db6728b0697ffb3f71b1ca9ceb5260c5454" target="_blank"&gt;&lt;strong&gt;Mourglia Ettlin, Gustavo&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Gonz&amp;aacute;lez, Carlos&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Crispo, Martina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Barth, Thomas F. E.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Casaravilla, Cecilia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Jenkins, Stephen J.&lt;/strong&gt;</text>
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                <text>&lt;a href="https://export.cvuy.uy/cv/?c855a45b7dae1af50c961a96b5eb15c26a7b943e53f84d972caa0f9ce21ec5f03ef21e57ce461b5656b60c7a13dbc71dbc1dad52a109e231d5b638ac5639067d" target="_blank"&gt;&lt;strong&gt;D&amp;iacute;az, Alvaro&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Infection and Immunity, v. 91, n&amp;deg;6, 2023</text>
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                <text>American Society for Microbiology</text>
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            <elementTextContainer>
              <elementText elementTextId="681463">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>In recent years major outbreaks of prion disease linked to oral exposure of the prion agent have occurred in animal and human populations. These disorders are associated with a conformational change of a normal protein, PrPC (prion protein cellular), to a toxic and infectious form, PrPSc (prion protein scrapie). None of the prionoses currently have an effective treatment. A limited number of active immunization approaches have been shown to slightly prolong the incubation period of prion infection. Active immunization in wild-type animals is hampered by auto-tolerance to PrP and potential toxicity. Here we report that mucosal vaccination with an attenuated Salmonella vaccine strain expressing the mouse PrP, is effective at overcoming tolerance to PrP and leads to a significant delay or prevention of prion disease in mice later exposed orally to the 139A scrapie strain. This mucosal vaccine induced gut anti-PrP immunoglobulin (Ig)A and systemic anti-PrP IgG. No toxicity was evident with this vaccination approach. This promising finding suggests that mucosal vaccination may be a useful method for overcoming tolerance to PrP and preventing prion infection among animal and potentially human populations at risk.</text>
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                <text>Neuroscience v. 133, no. 2, 2005. -- p. 413-421</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Multi-reference Cl calculation of the potential energy curves for OH-bond breaking in the ground and lowest excited states of the water monomer and dimer&lt;/strong&gt;</text>
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                <text>Ab initio multireference configuration interaction (MRCI) calculations of OH bond breaking in the water monomer and dimer are reported in this paper. Several basis sets and MRCI methodologies are tested in order to assess the quality of the expected results. Calculation of the hydrogen transfer curves in the dimer leads to the proposition that the coupling of excited states of A&amp;Prime; symmetry &amp;mdash; correlating to the state C̃1B1 in the equilibrium geometry of the monomer&amp;mdash;causes decomposition of the dimer into HO&amp;radic; and H3O&amp;radic; when it is attempted to obtain its resonance enhanced multiphoton ionization spectrum under similar conditions to those used for the water monomer.</text>
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                <text>&lt;strong&gt;Sosa, R.&lt;/strong&gt;</text>
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                <text>Journal of Molecular Structure (THEOCHEM)&amp;nbsp; v. 297, , 1993. -- p. 337-345</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis and other bone illnesses. Some of them have also shown antiparasitic activity. In search of improving the pharmacological profile of commercial bisphosphonates, our group had previously developed first row transition metal complexes with N-containing bisphosphonates (NBPs). In this work, we extended our studies to heteroleptic palladium&amp;ndash;NBP complexes including DNA intercalating polypyridyl co-ligands (NN) with the aim of obtaining potential multi-target species. Complexes of the formula [Pd(NBP)2(NN)]&amp;middot;2NaCl&amp;middot;xH2O with NBP&amp;thinsp;=&amp;thinsp;alendronate (ale) or pamidronate (pam) and NN&amp;thinsp;=&amp;thinsp;1,10 phenanthroline (phen) or 2,2&amp;prime;-bipyridine (bpy) were synthesized and fully characterized. All the obtained compounds were much more active in vitro against T. cruzi (amastigote form) than the corresponding NBP ligands. In addition, complexes were nontoxic to mammalian cells up to 50&amp;ndash;100 &amp;micro;M. Compounds with phen as ligand were 15 times more active than their bpy analogous. Related to the potential mechanism of action, all complexes were potent inhibitors of two parasitic enzymes of the isoprenoid biosynthetic pathway. No correlation between the anti-T. cruzi activity and the enzymatic inhibition results was observed. On the contrary, the high antiparasitic activity of phen-containing complexes could be related to their ability to interact with DNA in an intercalative-like mode. These rationally designed compounds are good candidates for further studies and good leaders for future drug developments.</text>
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                <text>&lt;strong&gt;Li, Zhu‑Hong&lt;/strong&gt;</text>
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                <text>Journal of Biological Inorganic Chemistry. v.25, no. 3, 2020. -- p. 509-519</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor &lt;/strong&gt;sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A new automated method for the determination of glucose in honey is proposed. The method is based on multicommutated flow analysis (MCFA) and employs an immobilized glucose oxidase reactor and spectrophotometric detection at 505nm of the red quinoneimine formed (Trinder&amp;rsquo;s method). The calibration curve obeyed a second order equation in the range 0&amp;ndash;0.14 g L&amp;minus;1 (h =&amp;minus;2.2199 C2 + 1.3741C + 0.0077, r2 = 0.9991, where h is the peak height (absorbance) and C the concentration in g L&amp;minus;1). The method was validated analyzing eight commercial samples, both by the AOAC 954.11 and 977.20 official methods. According to Student&amp;rsquo;s t-test of mean values, at the confidence level of 95% the results obtained with the proposed method were in agreement with those obtained by the official methods. Precision (sr(%), n = 10) was 3% and the sampling frequency of the system was 20 samples h&amp;minus;1.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A pilot annual monitoring survey (April 2018&amp;ndash;March 2019) was conducted to investigate the presence of pesticides in superficial water and fish in Laguna del Cisne, one of the most critical drinking water sources in Uruguay. A total of 25 pesticide residues were detected in superficial water (89.3 % of the samples). Pesticide's temporal distribution was as sociated with crops and livestock practices, with higher occurrences in spring and summer than in autumn and winter. The most frequent compounds in superficial water were the insecticide chlorantraniliprole, and the herbicides glyph osate (including its metabolite AMPA) and metolachlor. The levels of Organochlorine pesticide, p,p&amp;prime;-DDT, was in some cases two order of magnitude above the international water quality guidelines for Ambient Water Criteria. In fishes, eight different pesticides were detected, at concentrations from 1000 to 453,000 ng&amp;middot;kg&amp;minus;1 . The most frequent pesticides found were propiconazole, chlorpyrifos, and p,p&amp;prime;-DDE. The widespread occurrence of pesticides in fish suggests poten tial exposure effects on fish populations and the aquatic ecosystem. The sampling approach of this work allowed mon itoring the continuous concentrations of several pesticides in surface waters and fishes to establish the influence from past and current agriculture practices in Laguna del Cisne basin. For safety measures, continuous monitoring programs must be performed in this system to prevent toxicity impacts on aquatic organisms and human health.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse&lt;/p&gt;</text>
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                <text>Oxidative stress (OS) is an important consequence of exposure to toxic metals but it is unclear to what extent low-level metal exposures contribute to OS in children. We examined the cross-sectional association between urinary concentrations of arsenic (As), cadmium (Cd), and lead (Pb) and urinary markers of OS: F2-8&amp;alpha; isoprostane and 8-hydroxy-2-deoxy-guanosine (8-OHdG). We also tested effect modification by dietary intakes. Of the 211 children aged 6-8 years living in Montevideo who were eligible for the study because they had at least one OS marker measured via ELISA, 143 were included in a complete-case analysis. Urinary metals were measured with inductively coupled plasma mass spectrometry (ICP-MS: Pb, Cd) and high-performance liquid chromatography online with hydride generation ICP-MS (As-metabolites); concentrations were log2-transformed. All urinary markers were adjusted for specific gravity of urine. Two 24-h dietary recalls were conducted to estimate children's dietary intakes, including total fruit and vegetable consumption and vitamin C, zinc and fiber intake. Ordinary least square (OLS) and weighted quantile sum (WQS) regressions were used to estimate the association between metals and each OS marker as outcome. Metal exposure was generally low: median urinary As, Cd, Pb 9.6 &amp;mu;g/L, 0.06 &amp;mu;g/L and 1.9 &amp;mu;g/L, respectively. Median 8-isoprostane concentration was 1.1 and 8-OHdG 39.6 ng/mL. Log2-transformed urinary As concentrations were positively associated with 8-OHdG concentrations (10.90 [3.82, 17.97]) in covariate-adjusted OLS models which also took account of exposure to Cd and Pb. In WQS, a mixture index was also associated with higher 8-OHdG (8.71 [1.12, 16.3] for each 25% increase in index value), mostly driven by As exposure. There was little evidence of effect modification by dietary antioxidants. In sum, even at low-level, As exposure is associated with detectable oxidative damage to the DNA.</text>
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                <text>Environmental Research v. 166, 2018. -- p. 507-515</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The purpose of the study was to investigate the factors upon which the first order rate constant depends in order to assess the impact on the body-drug concentration when it changes throughout a treatment. A reasoning for linking the first order rate constants with several factors in a multiplicative way was proposed out taking into account kinetic and thermodynamic aspects. A multi-compartment model for drug disposition was analyzed and compartment mean drug concentrations at steady state were obtained as a function of the model kinetic constants. At the moment, only four factors were identified as responsible for the actual rate constant value. Apart from an intrinsic kinetic constant, they are the inverse of compartment volume, the transfer surface area, the fraction of mass able to be transferred, and the fraction of mass that effectively can be transferred. In clinical practice some of these factors might change throughout time (because of chronophysiological rhythms or drug availability at the action sites) and consequently, an inconstant extra-plasma/plasma drug concentration ratio could be obtained. In conclusion, therapeutic response prediction for a treatment does not upon plasma drug concentration monitoring. Equivalence in plasma drug exposure should not mean therapeutic equivalence, because differences in the rate and in the extent between test and reference products may induce a change in the action site/plasma drug concentration ratio.</text>
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                <text>European Journal of Drug Metabolism and Pharmacokinetics v. 29, no. 1, 2004. -- p. 43-49</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;Contain between 1 and 3 bullet points highlighting the customization rather than the steps of the procedure. An analytical methodology was adjusted and validated for the analysis of 15 selected pesticides currently employed in extensive agriculture. The main application of this methodology is studying the pesticides degradation behavior using biobeds as a friendly environmental tool for the treatment of wastewaters generated in fields. The scope of the method was selected based on the most used pesticides in soybean crops in Uruguay. The novelty of this work is the inclusion of neutral and acidic herbicides such as 2,4-D, clethodim, dicamba, together with fungicides and insecticides which are usually included in Multi Residue Methods. An acetonitrile extraction methodology without a clean-up step yielded acceptable results for all the analytes. The instrumental analysis was performed using HPLC-MS/MS. The selected methodology was validated according to the SANTE guidelines. The recoveries were between 65 and 130% with RSD &amp;lt; 20%. The instrumental LOQs were fixed at 1 &amp;micro;g/L for all the compounds except for clethodim, and the method LOQs were 1 mg/kg in biomixture dry basis. These LOQs values are acceptable for biodegradation studies in biobeds.&lt;/p&gt;&#13;
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                <text>MethodsXv.9, 2022.-- e101697</text>
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&lt;p&gt;&lt;span&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/span&gt;&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt;&lt;span&gt;&amp;nbsp;sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/span&gt;&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA:&lt;/strong&gt;&lt;span&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/span&gt;&lt;/p&gt;&#13;
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                <text>An efficient, fast, and accurate matrix solid-phase dispersion sample cleanup procedure was developed specifically for the determination of pesticide residues in lanolin. The scope of the method for organophosphorus, organochlorine, and pyrethroid insecticides is the same as that of official methods from various pharmacopeias. After lanolin dispersion on C18 bonded silica, pesticides are eluted with acetonitrile saturated with n-hexane. Recoveries ranged from 83 to 118% with RSD values of &amp;lt;20% for most pesticides listed, in compliance with the requirements of European and U.S. pharmacopeias.</text>
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                <text>Journal of the AOAC International v. 93, no. 2, 2010. -- p. 712-719</text>
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              <text>PDF</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>&lt;strong&gt;Multivariate analysis discrimination of various cold-pressed lemon oils from different geographical regions.&lt;/strong&gt;</text>
              </elementText>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="255559">
                <text>ACEITE DE LIMON</text>
              </elementText>
              <elementText elementTextId="255560">
                <text>ACEITES ESENCIALES</text>
              </elementText>
              <elementText elementTextId="255561">
                <text>HIDROCARBUROS</text>
              </elementText>
              <elementText elementTextId="255562">
                <text>PRODUCTOS NATURALES</text>
              </elementText>
              <elementText elementTextId="255563">
                <text>MONOTERPENOS</text>
              </elementText>
              <elementText elementTextId="255564">
                <text>SESQUITERPENOS</text>
              </elementText>
              <elementText elementTextId="255565">
                <text>ALDEHIDOS</text>
              </elementText>
              <elementText elementTextId="255566">
                <text>CROMATOGRAFIA DE GASES</text>
              </elementText>
              <elementText elementTextId="255567">
                <text>ESPECTROSCOPIA DE MASA</text>
              </elementText>
              <elementText elementTextId="255568">
                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
              </elementText>
              <elementText elementTextId="255569">
                <text>2010</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="87">
            <name>Abstract</name>
            <description>A summary of the resource.</description>
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              <elementText elementTextId="255570">
                <text>The main objective of present study was to investigate the influence of geographical region on the flavour compounds of various cold pressed lemon oils i.e. Argentinean, Ivory Cost, Italian, Spanish and Uruguayan. Among the flavor compounds, the major volatile flavour compounds from different chemical classes namely monoterpene hydrocarbons (i.e. limonene, sabinene plus &amp;beta;-pinene, &amp;gamma;-terpinene, myrcene, &amp;alpha;-pinene and &amp;alpha;-terpinolene), esters (i.e. neryl acetate and geranyl acetate), alcohol (i.e. &amp;alpha;-Terpineol) and aldehyde compounds (i.e. geranial and neral) were composed of &amp;gt; 90% of total volatile flavor compounds of target cold pressed lemon oils. Uruguayan essential oil had the least concentration level of all major classes of flavor compounds except for alcohol compounds; while the highest content of all chemical classes of flavor compounds identified in this study. The principle component analysis (PCA) allowed us to discriminate various cold pressed lemon oil based on their origin resource thereby classify their sensorial attributes.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="255571">
                <text>&lt;strong&gt;Kostadinovic, Sanja&lt;/strong&gt;</text>
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              <elementText elementTextId="255572">
                <text>&lt;strong&gt;Stefova, Marina&lt;/strong&gt;</text>
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              <elementText elementTextId="255573">
                <text>&lt;strong&gt;Nikolova, Diana&lt;/strong&gt;</text>
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              <elementText elementTextId="255574">
                <text>&lt;strong&gt;Nedelcheva, Daniela&lt;/strong&gt;</text>
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              <elementText elementTextId="255575">
                <text>&lt;strong&gt;Mart&amp;iacute;nez, Natalia&lt;/strong&gt;</text>
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              <elementText elementTextId="255576">
                <text>&lt;a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=c0795d953b6ad0c29a27b594ea61b600"&gt;&lt;strong&gt;Lorenzo, Daniel&lt;/strong&gt;&lt;/a&gt;</text>
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              <elementText elementTextId="255577">
                <text>&lt;a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2df81feedac99473a4e536d2623f04c3"&gt;&lt;strong&gt;Dellacassa, Eduardo&lt;/strong&gt;&lt;/a&gt;</text>
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              <elementText elementTextId="255578">
                <text>&lt;strong&gt;Mirhosseini, Hamed&lt;/strong&gt;</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="255579">
                <text>Journal of Food, Agriculture and Environment v. 8, no. 2, 2010. -- p. 117-121</text>
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          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="255580">
                <text>WFL</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="255581">
                <text>2010</text>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="255582">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="255583">
                <text>PDF</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="255584">
                <text>Ingl&amp;eacute;s</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="255585">
                <text>Art&amp;iacute;culo</text>
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    <tagContainer>
      <tag tagId="2733">
        <name>Aceite de limón</name>
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      <tag tagId="1442">
        <name>Aceites Escenciales</name>
      </tag>
      <tag tagId="1561">
        <name>Aldehídos</name>
      </tag>
      <tag tagId="732">
        <name>Cromatografía de gases</name>
      </tag>
      <tag tagId="2734">
        <name>Espectroscospia de masa</name>
      </tag>
      <tag tagId="1557">
        <name>Hidrocarburos</name>
      </tag>
      <tag tagId="118">
        <name>Monoterpenos</name>
      </tag>
      <tag tagId="205">
        <name>Productos naturales</name>
      </tag>
      <tag tagId="1986">
        <name>Sesquiterpenos</name>
      </tag>
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  </item>
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