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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New copper based complexes with quinoxaline N1, N4-dioxide derivatives, potential antitumoral agents</strong>
Subject
The topic of the resource
COMPLEJOS DE COBRE
AGENTES ANTITUMORALES
2008
BIBLIOGRAFÍA NACIONAL QUÍMICA
Abstract
A summary of the resource.
Taking into account our previous studies on cytotoxic metal compounds, new copper complexes with 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives as ligands were synthesized and characterized by different spectroscopic methods. The hypoxic selective cytotoxicity towards V79 cells and the superoxide dismutase-like activity of the complexes were determined and related to physicochemical properties of the compounds. In particular, the copper(II) complex with 3-amino-6-chloro-7-fluoroquinoxaline-2-carbonitrile N1,N4-dioxide showed cytotoxic selectivity in hypoxia being the most lipophilic compound of the series. On the contrary, the complex with 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide was cytotoxic but not selective and that with 3-amino-7-chloro-6-methoxy-quinoxaline-2-carbonitrile N1,N4-dioxide was not cytotoxic towards V79 cells neither in oxia nor in hypoxia in the assayed conditions. The σm Hammett substituent electronic descriptor was related to the effect in hypoxic conditions and the SOD-like activity was correlated to the effect in normoxia.
Creator
An entity primarily responsible for making the resource
<strong>Urquiola, Carolina</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>
<strong>Cabrera, Mauricio</strong>
<strong>Lavaggi, Marìa Laura</strong>
<strong>Cerecetto, Hugo</strong>
<strong>González, Mercedes</strong>
<strong>Lopez de Cerain, Adela</strong>
<strong>Monge, Antonio</strong>
<strong>Costa-Filho, Antonio J.</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042" target="_blank"><strong>Torre, María H.</strong></a>
Source
A related resource from which the described resource is derived
Journal of Inorganic Biochemistry v. 102, no. 1, 2008. -- p.119-126
Publisher
An entity responsible for making the resource available
Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
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Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
doi:10.1016/j.jinorgbio.2007.07.028
Agentes antitumorales
Complejos de cobre
-
https://riquim.fq.edu.uy/files/original/0f47d474099f581a3f61a3069e8778f6.pdf
fc087ff104f52e2b98f981583dbdd154
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New Copper(II)-L-Dipeptide-Bathophenanthroline complexes as potential anticancer agents—synthesis, characterization and cytotoxicity studies—and comparative DNA-Binding study of related phen complexes</strong>
Subject
The topic of the resource
COMPLEJOS DE COBRE
PEPTIDOS
ADN
ACTIVIDAD CITOTOXICA
FENANTROLINA
BIBLIOGRAFIA NACIONAL QUIMICA
2023
Abstract
A summary of the resource.
Searching for new copper compounds which may be useful as antitumor drugs, a series of new [Cu(L-dipeptide)(batho)] (batho:4,7-diphenyl-1,10-phenanthroline, L-dipeptide: Gly-Val, Gly Phe, Ala-Gly, Ala-Ala, Ala-Phe, Phe-Ala, Phe-Val and Phe-Phe) complexes were synthesized and characterized. To interpret the experimental IR spectra, [Cu(ala-gly)(batho)] was modelled in the gas phase using DFT at the B3LYP/LANL2DZ level of theory and the calculated vibrational frequencies were analyzed. Solid-state characterization is in agreement with pentacoordinate complexes of the general formula [Cu(L-dipeptide)(batho)]·x solvent, similar to other [Cu(L-dipeptide)(diimine)] complexes. In solution, the major species are heteroleptic, as in the solid state. The mode of binding to the DNA was evaluated by different techniques, to understand the role of the diimine and the dipeptide. To this end, studies were also performed with complexes [CuCl2 (diimine)], [Cu(L dipeptide)(diimine)] and free diimines, with phenanthroline, neocuproine and 3,4,7,8-tetramethyl phenanthroline. The cytotoxicity of the complexes was determined on human cancer cell lines MDA-MB-231, MCF-7 (breast, the first triple negative), and A549 (lung epithelial) and non-tumor cell lines MRC-5 (lung) and MCF-10A (breast). [Cu(L-dipeptide)(batho)] complexes are highly cytotoxic as compared to cisplatin and [Cu(L-dipeptide)(phenanthroline)] complexes, being potential candidates to study their in vivo activity in the treatments of aggressive tumors for which there is no curative pharmacological treatment.
Creator
An entity primarily responsible for making the resource
<a href="https://export.cvuy.uy/cv/?6ff98e50c61daf2fd24006b2cb221c82" target="_blank"><strong>Fernández, Carlos Y.</strong></a>
<a href="https://export.cvuy.uy/cv/?e635b6babb330f7d853c44bebf28147f45249ebe02a83f148a2cc7d1d4cfc6eb7c052c905498e0db71ce84c545c5bc262c0c1fa15dd485e385d82024819cf422" target="_blank"><strong>Alvarez, Natalia</strong></a>
<strong>Rocha, Analu</strong>
<strong>Ellena, Javier</strong>
<strong>Costa Filho, Antonio J.</strong>
<strong>Batista, Alzir A.</strong>
<a href="https://export.cvuy.uy/cv/?a41bd5cdd282cee0c5c8be3585cd7593514fcf7fb722e1194e086a5aa98159780502b217d616fd5bb450c02a6152253b7a8957278f35e3a01aabdd446a54f376" target="_blank"><strong>Facchin, Gianella</strong></a>
Source
A related resource from which the described resource is derived
Molecules v.28, n°2, 2023
Publisher
An entity responsible for making the resource available
MDPI
Date
A point or period of time associated with an event in the lifecycle of the resource
2023
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Extent
The size or duration of the resource.
14 p.
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
10.3390/molecules28020896
Actividad citotóxica
ADN
Complejos de cobre
Fenantrolina
Péptidos
-
https://riquim.fq.edu.uy/files/original/23ed57d79c96ae68e8b36d6afd679a84.pdf
47a04f8f934ca1a865868e503e4e507f
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New derivates of 2-diphenylmethoxyethylamine with vasodilator and spasmolytic activity</strong>
Subject
The topic of the resource
MEDICINA
ESTUDIOS CLINICOS
BIBLIOGRAFIA NACIONAL QUIMICA
1977
Creator
An entity primarily responsible for making the resource
<strong>Ibañez, A.</strong>
<strong>Roig, M.</strong>
<strong>Ruiz, J.</strong>
<strong>Queralt, J.</strong>
<strong>De Catellarnan, C.</strong>
<strong>Badia, A.</strong>
Source
A related resource from which the described resource is derived
European Journal of Medicinal Chemistry - Chimica Therapeutica v. 12, nº. 5, 1977. -- p. 459-462
Publisher
An entity responsible for making the resource available
Société de chimie thérapeutique (France)
Date
A point or period of time associated with an event in the lifecycle of the resource
1977
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
ISSN: 0223-5234
Estudios clínicos
Medicina
-
https://riquim.fq.edu.uy/files/original/ed8b200e832c19d0a3e530984e409fba.pdf
e178036d9674f251826713e8851bbff2
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New directions towards safer and effective vaccines for Alzheimer´s disease.</strong>
Subject
The topic of the resource
ENFERMEDAD DE ALZHEIMER
VACUNAS
INMUNOLOGIA
BIBLIOGRAFIA NACIONAL QUIMICA
2005
Abstract
A summary of the resource.
The first experimental vaccine against Alzheimer's disease caused encephalitis in some patients, which led to termination of the clinical trial and dealt a serious blow to this therapeutic approach. With second-generation vaccines that are likely to circumvent this side effect, this type of therapy remains promising, although more extensive animal studies are likely to be required before approval of other clinical trials. Another potential side effect, microhemorrhages within the brain vasculature, has been observed in mouse models following passive immunization, but has not been assessed in reports of active vaccination. Together, these serious adverse reactions emphasize the need to test potential Alzheimer's immunotherapy in large cohorts of primate models prior to, or at least concurrently with, human trials, as no effective therapy exists for the disease.
Creator
An entity primarily responsible for making the resource
<strong>Goñi, Fernando</strong>
<strong>Sigurdsson, E. M</strong>
Source
A related resource from which the described resource is derived
Current Opinion in Molecular Therapeutics v. 7, no. 1, 2005. -- p. 17-23
Publisher
An entity responsible for making the resource available
Thomson
Date Available
Date (often a range) that the resource became or will become available.
2005
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
<p> </p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
ISSN: 1464-8431
Enfermedad de Alzheimer
Inmunología
Vacunas
-
https://riquim.fq.edu.uy/files/original/aac8778553c4064c1030b2beefae26ae.pdf
e178036d9674f251826713e8851bbff2
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New effects in the electrochemistry of carbon dioxide on platinum by the solid-state reactions occurring via a two-phase or single-phase solid solution pathway.</strong>
Subject
The topic of the resource
ELECTROQUIMICA
DIOXIDO DE CRBONO
PLATINO
BIBLIOGRAFIA NACIONAL QUIMICA
1999
Abstract
A summary of the resource.
The electroformation and electrooxidation of carbon dioxide adsorbates were studied on polycrystalline and preferentially oriented platinum surfaces by the application of medium frequency potential perturbations in saturated carbon dioxide aqueous sulphuric acid solutions. Preferentially oriented platinum surfaces were obtained by the application of fast symmetric square wave potential programmes to polycrystalline electrodes based on well-known methodology. Two new electrochemical characteristics for the electrochemistry of carbon dioxide were observed after the application of the medium frequency routines, that is, an extended adsorption potential domain for the formation of carbon dioxide adsorbates, and novel voltammetric features for the two anodic stripping peaks. These effects upon carbon dioxide electrochemistry are dependent on the morphology of the platinum electrode surface and adsorption potentials.
Creator
An entity primarily responsible for making the resource
<strong>Mendez, Eduardo</strong>
<strong>Martins, M.E</strong>
<strong>Zinola Sánchez, Carlos Fernando</strong>
Source
A related resource from which the described resource is derived
Journal of electroanalytical chemistry v. 477, no. 1, 1999. -- p. 41
Publisher
An entity responsible for making the resource available
Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
doi:10.1016/S0022-0728(99)00387-3
Dióxido de carbono
Electroquímica
Platino
-
https://riquim.fq.edu.uy/files/original/050c877085e94df28635c92f9ddf10fe.pdf
b8a192aa2de8eb7140fa07e15a1ff814
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New fac-tricarbonyl rhenium(I) semicarbazone complexes: synthesis, characterization, and biological evaluation</strong>
Subject
The topic of the resource
RENIO
TRIPANOSOMIASIS
SEMICARBAZONAS
COMPLEJOS
BIBLIOGRAFIA NACIONAL QUIMICA
2014
Abstract
A summary of the resource.
Expanding our previous work on salicylaldehyde semicarbazone metal complexes as prospective anti-trypanosomal agents, five new fac-ReI(CO)3-containing complexes with ligands of this semicarbazone series were synthesized and characterized. An atypical coordination mode of these potentially tridentate ligands through only the carbonylic oxygen and the azomethine nitrogen (the so-called N,O fashion) was demonstrated by IR spectroscopy and supported by theoretical calculations. Three of the compounds showed moderate in vitro anti-Trypanosoma cruzi activity and increased activity with respect to the corresponding free ligands. The brominated ligands, 5-bromo-2-hydroxybenzaldehyde semicarbazone (L2) and 5-bromo-2-hydroxy-3-methoxybenzaldehyde semicarbazone (L5), led to the most active rhenium(I) complexes. These compounds are among the few reported examples of rhenium complexes bearing in vitro activity against T. cruzi.
Creator
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<strong>Machado, Ignacio</strong>
<strong>Fernández, Soledad</strong>
<strong>Becco Sierra, Lorena Lourdes</strong>
<strong>Garat Bizzozero, Beatriz Maria</strong>
<strong><a title="currículum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=fd97168d9e8b7d3f82474969b5b78453" target="_blank">Gancheff, Jorge S.</a></strong>
<a title="currículum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=9b0f413dec677697679ef0eb972502e2" target="_blank"><strong>Rey, Ana</strong></a>
<a title="currículum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>
Source
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Journal of Coordination Chemistry v. 67, no. 10, 2014. -- p. 1835-1850
Publisher
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Taylor & Francis Group
Date
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2014
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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DOI:10.1080/00958972.2014.926008
Complejos
Renio
Semicarbazonas
Tripanosomiasis
-
https://riquim.fq.edu.uy/files/original/960d571b5e31bb25c87fcf2baf2c712e.pdf
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Title
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Bibliografía Nacional Química
Description
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Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
Document
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PDF
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Title
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<strong>New family of thiocyanate-bridged Re(IV)-SCN-M(II) (M = Ni, Co, Fe, and Mn) heterobimetallic compounds : Synthesis, crystal structure, and magnetic properties</strong>
Subject
The topic of the resource
METALES
QUIMICA INORGANICA
COMPLEJOS
TIOCIANATO
BIBLIOGRAFIA NACIONAL QUIMICA
2012
Abstract
A summary of the resource.
<p>The heterobimetallic complexes of formula [(Me2phen)2M(μ-NCS)- Re(NCS)5]·CH3CN [Me2phen = 2,9-dimethyl-1,10-phenanthroline and M = Ni (1), Co (2), Fe (3), and Mn (4)] have been prepared, and their crystal structures have been determined by X-ray diffraction on single crystals. Compounds 1−4 crystallize in the monoclinic C2/c space group, and their structure consists of neutral [(Me2phen)2M(μ-NCS)Re(NCS)5] heterodinuclear units with a Re-SCN-M bridge. Each Re(IV) ion in this series is six-coordinated with one sulfur and five nitrogen atoms from six thiocyanate groups building a somewhat distorted octahedral environment, whereas the M(II) metal ions are five-coordinated with four nitrogen atoms from two bidentate Me2phen molecules and a nitrogen atom from the bridging thiocyanate describing distorted trigonal bipyramidal surroundings. The values of the Re···M separation through the thiocyanate bridge in 1−4 vary in the range 5.903(1)− 6.117(3) Å. The magnetic properties of 1−4 as well as those of the parent mononuclear Re(IV) compounds (NBu4)2[Re(NCS)6] (A1) (NBu4 + = tetra-n-butylammonium cation) and [Zn(NO3)- (Me2phen)2]2[Re(NCS)5(SCN)] (A2) were investigated in the temperature range 1.9−300 K. Weak antiferromagnetic interactions between the Re(IV) and M(II) ions across the bridging thiocyanate were found in 1−4 [J = −4.3 (1), −2.4 (2), −1.8 (3), and −1.2 cm−1 (4), the Hamiltonian being defined as Ĥ = −JŜRe·ŜM]. The magnetic behavior of A2 is that of a magnetically diluted Re(IV) complex with a large and positive value of the zero-field splitting for the ground level (DRe = +37.0 cm−1). In the case of A1, although its magnetic behavior is similar to that of A2 in the high-temperature range (DRe being +19.0 cm−1), it exhibits a weak ferromagnetism below 3.0 K with a canting angle of 1.3°.</p>
Creator
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<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b1b5b2e2cf087c725fd16c86fe84f724" target="_blank"><strong>González, Ricardo</strong></a>
<strong>Acosta, Alvaro</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=ee0fd5f657739f812de617121a701ab6" target="_blank"><strong>Chiozzone, Raul</strong></a>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6f16399c452f7b13f8a01a148cb38e12" target="_blank"><strong>Kremer, Carlos</strong></a>
<strong>Armentano, D.</strong>
<strong>De Munno, G.</strong>
<strong>Julve, M.</strong>
<strong>Lloret, F.</strong>
<strong>Faus, J.</strong>
Source
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Inorganic Chemistry 51, no. 10, 2012. -- p. 5737-5747
Publisher
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American Chemical Society
Date
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2012
Rights
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<p align="LEFT"><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p style="margin-bottom: 0cm;"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
<p><br /><br /></p>
<p style="margin-bottom: 0cm;"> </p>
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PDF
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Inglés
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dx.doi.org/10.1021/ic300200k
Complejos
Metales
Química Inorgánica
Tiocianatos
-
https://riquim.fq.edu.uy/files/original/4237ba753792d29750e7b9528e1e1c45.pdf
00856400ed20b3ff9ad90ff1d68f3dcc
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3
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
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<strong>New functional fibre in milk puddings : effect on sensory properties and consumers`acceptability</strong>
Subject
The topic of the resource
ANALISIS SENSORIAL
LECHE
ALIMENTOS
BIBLIOGRAFIA NACIONAL QUÍMICA
2009
FIBRAS
Abstract
A summary of the resource.
<p>The effect of the addition of a new functional fibre (high-amylose maize starch, HAMS, as a source of resistant starch), recently available in the market, on <strong>sensory characteristics</strong> and consumers' acceptability of <strong>milk puddings</strong> was studied. Milk puddings containing modified waxy maize starch and κ-carrageenan were produced with different HAMS concentrations (0, 1, 2, 3 and 4%). Higher HAMS concentration caused changes in the sensory characteristics of milk puddings. Particularly, sensory attributes such as some roughness, rough afterfeel and floury taste appeared. Besides, the addition of HAMS caused an increase in manual and oral thickness and a decrease in creaminess, melting, and sweetness. A HAMS enrichment level of 1.4% in this product was estimated as the maximum concentration that does not significantly modify consumers' overall acceptability. Using survival analysis the proportion of consumers who would buy milk desserts containing 1.4 % HAMS was estimated as 71%.<strong> Consumers</strong> more interested in consuming functional foods enriched with fibre were more tolerant to the sensory changes caused by the addition of HAMS to the <strong>milk puddings</strong>.</p>
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<a href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=358965ab1701bacbb43e4f5a24a8e876"><strong>Ares, Gastón</strong></a>
<strong>Baixauli, Raquel</strong>
<strong>Sanz, Teresa</strong>
<strong>Varela, Paula</strong>
<strong>Salvador, Ana</strong>
Source
A related resource from which the described resource is derived
LWT-Food Science and Technology v.42, no. 3, 2009. -- p.710-716
Publisher
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Elsevier
Date
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2009
Rights
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<p><em><strong>Información sobre Derechos de Autor</strong> </em></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><em><strong>La legislación uruguaya</strong></em> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><em><strong> ADVERTENCIA</strong></em> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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PDF
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Inglés
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Artículo
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DOI 10.1016/j.lwt.2008.10.004
Evaluación sensorial
Postres de leche
-
https://riquim.fq.edu.uy/files/original/9249e8a7b13409031aa4483c359a63a0.pdf
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
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<strong>New Functional Ingredients From Agroindustrial By-Products for the Development of Healthy Foods</strong>
Subject
The topic of the resource
ALIMENTOS
ALIMENTOS SALUDABLES
ALIMENTOS FUNCIONALES
ALIMENTOS FUNCIONALES
ANTIOXIDANTES
FIBRSS IETETICAS
BIBLIOGRAFIA NACIONAL QUIMICA
2018
Abstract
A summary of the resource.
The present study aimed to obtain novel information regarding the pathways of a polyphenol-rich coffee silverskin extract (CSE) for inhibiting the formation of advanced glycation products (AGE). Chlorogenic acid (CGA) is the main phenol present in coffee beans. The contribution of CGA to the antiglycoxidative properties of CSE was also evaluated by analysis of CGA standard. The CGA (90%) and CSE (49%) significantly inhibited (p < 0.001) the formation of fluorescent AGE in a protein–methylglyoxal (MGO) model system (37 °C for 96 h). The lack of MGO-derivative AGE in the presence of CGA and CSE was verified using liquid chromatography–tandem mass spectrometry techniques, which evidenced the almost complete absence of arginine adducts after 24 h of reaction. The inhibitory effect of polyphenols present in CSE may be associated to its carbonyl trapping capacity as well as to its ability to react with side-chains of protein amino residues blocking the reaction sites. In conclusion, aqueous CSE can be considered a natural source of various inhibitors of in vitro formation of AGE acting by different pathways. Inhibitors of advanced glycation end products from coffee bean roasting by-product
Creator
An entity primarily responsible for making the resource
<strong>Cozzano Ferreira, Sonia</strong>
<strong>Fernández Fernández, Adriana Maite.</strong>
<strong>del Castillo Bilbao, María Dolores</strong>
<strong>Medrano Fernandez, Alejandra</strong>
Source
A related resource from which the described resource is derived
Encyclopedia of Food Security and Sustainability / Pasquale Ferranti Elliot Berry Anderson Jock, edsr, 2018 p. 1-9
Publisher
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Elsevier
Date
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2018
Rights
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<p><strong>Información sobre Derechos de Auto</strong>r</p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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PDF
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Inglés
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Artículo
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DOI: 10.1016/B978-0-08-100596-5.22140-9
Alimentos
Alimentos funcionales
Alimentos saludables
Antioxidantes
Fibras dieteticas
Salvado de arroz
-
https://riquim.fq.edu.uy/files/original/a7dfdbde8f08d3ea5c45d54c6711d9e8.pdf
e178036d9674f251826713e8851bbff2
https://riquim.fq.edu.uy/files/original/dfadb16213f37a963621bd33c68a127c.bmp
84c4150aaa571f0f96485d38f5bd513f
Dublin Core
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems.</strong>
Subject
The topic of the resource
RESONANCIA DE SPIN ELECTRONICO
TRIPANOSOMIASIS
COMPUESTOS HETEROCICLICOS
CINETICA
BIOLOGIA
EXPERIMENTOS CON ANIMALES
BIBLIOGRAFIA NACIONAL QUIMICA
2010
Abstract
A summary of the resource.
their free radical-trapping properties. The physicochemical characterization by electron paramagnetic resonance (EPR) demonstrated its capability to trap and stabilize oxygen-, carbon-, sulfur-, and nitrogen- centered free radicals. The 4-furoxanyl nitrone 3 (FxBN), a(Z)-(3-methylfuroxan-4-yl)-N-tert-butylnitrone, showed appropriate solubility in aqueous solution and taking into account that this physicochemical property is very important for biological applications, we studied it deeply in terms of its trapping and kinetic behaviors. For this, kinetic studies of the hydroxyl adduct decay gave rate constants kST of 1.22 � 1010 dm3 mol�1 s�1 and half-live up to 7200 s at physiological pH, without any artifactual signals. The ability of FxBN to directly traps and stabilizes superoxide free radical, with a half-life of 1620 s at physiological pH, was also demonstrated. Besides, FxBN-hydroxyl and -superoxide adducts exhibited distinct and characteristic EPR spectral patterns. Finally, we confirmed the ability of FxBN to act as spin trap in a specific biological system, that is, in the free radical production of experimental anti-trypanosomatid drugs using Trypanosoma cruzi microsomes as biological system. Moreover, previous observations of low FxBN toxicity transform it in a good candidate for in vivo spin trapping
Creator
An entity primarily responsible for making the resource
<strong>Barriga, Germán</strong>
<strong>Olea-Azar, Claudio</strong>
<strong>Norambuena, Ester</strong>
<strong>Castro, Ana</strong>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=01ded1b48a793797e49a8cb9b67aecea"><strong>Porcal, Williams</strong></a>
<strong>Gerpe, Alejandra</strong>
<strong>González, Mercedes</strong>
<strong>Cerecetto, Hugo</strong>
Source
A related resource from which the described resource is derived
Bioorganic and Medicinal Chemistry v. 18, no. 2, 2010. -- p. 795-802
Publisher
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Elsevier
Date
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2010
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
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Inglés
Type
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Artículo
Identifier
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doi:10.1016/j.bmc.2009.11.053
Cinetica
Compuestos heterociclicos
Experimentos con animales
Resonancia de spin electrónico
Tripanosomiasis
-
https://riquim.fq.edu.uy/files/original/c9574a75289470e1d2b79f4381b00c44.pdf
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Title
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Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
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Departamento de Documentación y Biblioteca
RIQUIM
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PDF
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Title
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<strong>New heterobimetallic ferrocenyl derivatives : Evaluation of their potential as prospective agents against trypanosomatid parasites and Mycobacterium tuberculosis</strong>
Subject
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LEISHMANIASIS
TUBERCULOSIS
ANTITRIPANOSOMAS
BIBLIOGRAFIA NACIONAL QUIMICA
2018
Abstract
A summary of the resource.
Searching for prospective agents against infectious diseases, four new ferrocenyl derivatives, [M(L)(dppf)4](PF6), with M = Pd(II) or Pt(II), dppf = 1,1'-bis(dipheny1phosphino) ferrocene and HL = tropolone (HTrop) or hinokitiol (HHino), were synthesized and characterized. Complexes and ligands were evaluated against the bloodstream form of T. brucei, L. infantum amastigotes, M. tuberculosis (MTB) sensitive strain and MTB clinical isolates. Complexes showed a significant increase of the anti-T. brucei activity with respect to the free ligands (>28- and >46-fold for Trop and 6- and 22-fold for Hino coordinated to Pt-dppf and Pd-dppf, respectively), yielding IC50 values < 5 μM. The complexes proved to be more potent than the antitrypanosomal drug Nifurtimox. The new ferrocenyl derivatives were more selective towards the parasite than the free ligands. The Pt compounds were less toxic on J774 murine macrophages (mammalian cell model), than the Pd ones, showing selectivity index values (SI = IC50 murine macrophage/IC50T. brucei) up to 23. Generation of the {M-dppf} compounds lead to a slightly positive impact on the anti-leishmanial potency. Although the ferrocenyl derivatives were more active on sensitive MTB than the free ligands (MIC90 = 9.88-14.73 μM), they showed low selectivity towards the pathogen. Related to the mechanism of action, the antiparasitic effect cannot be ascribed to an interference of the compounds with the thiol-redox homeostasis of the pathogen. Fluorescence measurements pointed at DNA as a probable target of the new compounds. [Pt(Trop)(dppf)](PF6) and [Pt(Hino)(dppf)](PF6) could be considered prospective anti-T. brucei agents that deserve further research.
Creator
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<strong>Rivas, Feriannys</strong>
<strong>Medeiros, Andrea</strong>
<strong>Rodríguez Arce, Esteban</strong>
<strong>Comini, Marcelo</strong>
<strong>Ribeiro, Camila M.</strong>
<strong>Pavan, Fernando R.</strong>
<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_self"><strong>Gambino, Dinorah.</strong></a>
Source
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Journal of Inorganic Biochemistry v. 187, 2018. -- p. 73-84
Publisher
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Elsevier
Date
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2018
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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Artículo
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DOI: 10.1016/j.jinorgbio.2018.07.013
Antitripanosomas
Leishmaniasis
Tuberculosis
-
https://riquim.fq.edu.uy/files/original/d0f95e8bd83de06cbfeef8159561609b.pdf
0ebebc2e46cd599f97051dd7aefd7031
https://riquim.fq.edu.uy/files/original/3c290421aab6ed4d279c42c7193d416e.jpg
cdd0a2ce312bf4e70b711012e597d666
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
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Title
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<strong>New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents</strong>
Subject
The topic of the resource
ENFERMEDAD DE CHAGAS
TRIPANOSOMIASIS
ANTITRIPANOSOMAS
BIBLIOGRAFIA NACIONAL QUIMIC
2019
Abstract
A summary of the resource.
In the search for a more effective chemotherapy for the treatment of Chagas’ disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic compounds may be a promising strategy. In this work, eight new heterobimetallic compounds are described including four 5-nitrofuryl containing thiosemicarbazones as bioactive ligands (HL1–HL4) and dppf = 1,1′-bis(diphenylphosphino) ferrocene as an organometallic co-ligand. Complexes of the formula [MII(L)(dppf)](PF6) with M = Pd or Pt were synthesized and fully characterized in the solid state and in solution, including the determination of the molecular structure of four of them by single crystal X-ray diffraction methods. Most compounds showed activity in the low micromolar or submicromolar range against both parasites, with the platinum compounds being more active than the palladium analogues. Activity was significantly increased by generation of the M-dppf compounds (3–24 fold increase with respect to free ligands HL for T. cruzi and up to 99 fold increase with respect to HL for T. brucei). The inclusion of the organometallic co-ligand also led to lower toxicity in mammalian cells and higher selectivity towards both parasites when compared to the free HL compounds. The complexes interact with DNA and affect the redox metabolism of the parasites. Furthermore, the most active and selective compound of the new series showed no in vivo toxicity in zebrafish embryos.
Creator
An entity primarily responsible for making the resource
<strong>Rodríguez Arce, Esteban</strong>
<strong>Putzu, Eugenia</strong>
<strong>Lapier, Michel</strong>
<strong>Maya, Juan Diego</strong>
<strong>Olea-Azar, Claudio.</strong>
<strong>Echeverría, Gustavo A</strong>
<strong>Piro, Oscar E.</strong>
<strong>Medeiros, Andrea</strong>
<strong>Sardi, Florencia</strong>
<strong>Comini, Marcelo</strong>
<strong>Risi, Gastón.</strong>
<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8b2cacb0aafc512133624fa7b9bf174c" target="_self"><strong>Salinas, Gustavo.</strong></a>
<strong>Correia, Isabel</strong>
<strong>Costa Pessoa, João</strong>
<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b2795d82d8f9cb610b167b6577f861a5" target="_self"><strong>Otero Zubiaurre, Ana Lucía</strong></a>
<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_self"><strong>Gambino, Dinorah.</strong></a>
Source
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Dalton Transactions v. 48, no. 22, 2019.--p. 7644-7658
Publisher
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Royal Society of Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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PDF
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Inglés
Type
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Artículo
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DOI: 10.1039/C9DT01317B
Antitripanosomas
Enfermedad de chagas
Tripanosomiasis
-
https://riquim.fq.edu.uy/files/original/2d35593ea06e55239441f8aaac656804.pdf
0ebebc2e46cd599f97051dd7aefd7031
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Title
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Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
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If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
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<strong>New heteroleptic oxidovanadium(V) complexes: synthesis, characterization and biological evaluation as potential agents against Trypanosoma cruzi</strong>
Subject
The topic of the resource
VANADIO
BIOLOGIA
OXIDOVANADIO
COMPLEJOS
SINTESIS QUIMICA
TRIPANOSOMA CRUZI
BIBLIOGRAFIA NACIONAL QUIMICA
2018
Abstract
A summary of the resource.
Searching for prospective vanadium-based agents against Trypanosoma cruzi, the parasite causing Chagas disease, four new [VVO(8HQ–H)(L–2H)] compounds, where 8HQ is 8-hydroxyquinoline and L are tridentate salicylaldehyde semicarbazone derivatives L1–L4, were synthesized and characterized in the solid state and in solution. The compounds were evaluated on T. cruzi epimastigotes (CL Brener) as well as on VERO cells, as mammalian cell model. Compounds showed activity against T. cruzi (IC50 6.2–10.5 μM) of the same order than Nifurtimox and 8HQ, and a four- to sevenfold activity increase with respect to the free semicarbazones. For comparison, [VVO2(L–H)] series was prepared and the new [VVO2(L3–H)] was fully characterized. They showed negligible activity and low selectivity towards the parasite. The inclusion of 8HQ as ligand in [VVO(8HQ–H)(L–2H)] compounds led to good activities and increased selectivity towards the parasite with respect to 8HQ. 51V NMR experiments, performed to get insight into the nature of the active species, suggested partial decomposition of the compounds in solution to [VVO2(L–H)] and 8HQ. Depending on the dose, the compounds act as trypanocide or trypanostatic. A high uptake of vanadium in the parasites (58.51–88.9% depending on dose) and a preferential accumulation in the soluble protein fraction of the parasite was determined. Treated parasites do not seem to show a late apoptotic/necrotic phenotype suggesting a different cell death mechanism. In vivo toxicity study on zebrafish model showed no toxicity up to a 25 µM concentration of [VVO(8HQ–H)(L1–2H)]. These compounds could be considered prospective anti-T. cruzi agents that deserve further research.
Creator
An entity primarily responsible for making the resource
<strong>Scalese, Gonzalo</strong>
<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=5c1ca4d55a5933a1752b3fc23d7cad09c4e5df59004aa474d3d272c7b6b5d79efe1957de15b2f0c75050b8d88b94dc89f36f3a8703836670d171bb4291eb6134&formato=pdf&convocatoria=21" target="_self"><strong>Machado, Ignacio</strong></a>
<strong>Risi, Gastón</strong>
<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=972518dae04cc6f1d53fd01909f7c2f4952184c3eedf364530afd35a4c507484cce1f86606ac8d829a37e89b7a9f837b6b0632e94efbaf9ba6abf23efe48f1dc&formato=pdf&convocatoria=21" target="_self"><strong>Salinas, Gustavo.</strong></a>
<strong>Pérez-Díaz, Leticia.</strong>
<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=6bb5dcce3e2559101357796ca4a2b2d4c9ba6b3a978a0bd4c5dab0107081b73e1ff46dcf49a7de2b571ff7980c4a01789f09f1d7eac1b879a8553641f940b9a5&formato=pdf&convocatoria=21" target="_self"><strong>Gambino, Dinorah</strong></a>
Source
A related resource from which the described resource is derived
Journal of Biological Inorganic Chemistry v. 23, no. 8, 2018. -- p. 1265-1281
Publisher
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Springer
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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PDF
Language
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Inglés
Type
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Artículo
Identifier
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DOI: 10.1007/s00775-018-1613-1
Biologia
Complejos
Oxivanadio
Síntesis Química
Vanadio
-
https://riquim.fq.edu.uy/files/original/0f63c5e52f47d2e53ea4855c7ec0b81f.pdf
381081c6197b4d45a931a88b922a3eeb
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3
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150
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112
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New hexanuclear FeIII clusters with the gem-diol hydrated form of di(2-pyridyl)ketone and carboxylato ligands : Crystal structures and magnetic properties</strong>
Subject
The topic of the resource
HIERRO
COMPLEJOS DE HIERRO
CARBOXILATOS DE HIERRO
ESTRUCTURA CRISTALINA
PROPIEDADES MAGNETICAS
BIBLIOGRAFIA NACIONAL QUIMICA
2019
Abstract
A summary of the resource.
The hexanuclear compounds [Fe6O2Cl2{(py)2CO2}2(pyOH)2(pyCOO)2(ButCOO)6] (1) and [Fe6O2{(py)2CO2}2(pyCOO)4(ButCOO)6] (2) were obtained by condensation of the trinuclear μ3-oxo-centered iron(III) pivalate [Fe3O(ButCOO)6(H2O)3]+ in the presence of di(2-pyridyl)ketone [(py)2CO] in MeCN at ambient temperature. Both complexes contain an analogous core which can be described as two {Fe3O}7+ units joined by gem-diolato (py)2CO22− bridges. Variable-temperature magnetic susceptibility measurements in polycrystalline samples of 1 and 2 reveal strong antiferromagnetic couplings between the iron(III) ions leading to S = 0 ground states.
Creator
An entity primarily responsible for making the resource
<a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=2d464bf82e7bcaa15f4b0fbb018032c3001b5ddbb2f3240974290c1101a83a48fdf510e499125c718077733be2e225e06e5bc041529e5912a19205af86801bf0&formato=pdf&convocatoria=21" target="_self"><strong>Arizaga, Livia.</strong></a>
<strong>Canon-Mancisidor, Walter</strong>
<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=2ahUKEwiZ-IW13b_mAhW2HrkGHc3xC5wQFjAAegQIAxAH&url=https%3A%2F%2Fexportcvuy.anii.org.uy%2FCvEstatico%2F%3FurlId%3D527cc3038d59833a4c909767bd7f6a3379095d3a0cdc61b11c5885fee523d22afd20bae2ffe6db18c286b4d96984040347c98393790883f271799b54992d9ed0%26formato%3Dpdf%26convocatoria%3D21&usg=AOvVaw3AobPa3tMci0Na0a8ZOfMc" target="_self"><strong>Gancheff, Jorge S.</strong></a>
<strong>Burrow, Robert A.</strong>
<strong>Armentano, Donatella</strong>
<strong>Lloret, Francesc</strong>
<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwic5JOE37_mAhUpD7kGHZ2MCFYQFjAAegQIBBAH&url=https%3A%2F%2Fexportcvuy.anii.org.uy%2FCvEstatico%2F%3FurlId%3D441a03bd8b19a2050aec9a8e68a67aab53e2c04a9ff331e972a69b567b7ffde10472a7d926a2e9038b1940d8e9272a7de07b765740f899b7d19482d36bb42e8a%26formato%3Dpdf%26convocatoria%3D21&usg=AOvVaw1lvZDX6E39nfcna886BIqT" target="_self"><strong>González, Ricardo.</strong></a>
<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwiA1dyZ4b_mAhUoILkGHbfJBZsQFjAAegQIBxAH&url=https%3A%2F%2Fexportcvuy.anii.org.uy%2Fpdf%2F%3F9e450ba14cecd9ab4f3eb3afee24db93c31091b76bdf313eaf4bb6f48e1aab267b159257e1da3edcf0943d49db8b33f104e170e20dcc8350cdee43a625f33f4e&usg=AOvVaw2011uKHQ_YWNSlDG5L6UcB" target="_self"><strong>Kremer, Carlos</strong></a>
<a title="Curriculum Vitae" href="https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwirq5vY2b_mAhVpG7kGHRxyBREQFjABegQIBBAH&url=https%3A%2F%2Fexportcvuy.anii.org.uy%2FCvEstatico%2F%3FurlId%3Dfdc403cc2b5146f119b01b540242116f1f09385415a6b12eebb82d2c05b42428fc10f0c6bf466344fd2279f7bffabe5c80586019535e4bc933f888249364399e%26formato%3Dpdf%26convocatoria%3D21&usg=AOvVaw0a5_TSzwu3Xendud2IVpH6" target="_self"><strong>Chiozzone, Raúl</strong></a>
Source
A related resource from which the described resource is derived
Polyhedron v. 174, 2019. --10p.--e114165
Publisher
An entity responsible for making the resource available
Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislación uruguaya protege el derecho de autor</strong> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
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Inglés
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Artículo
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DOI: 10.1016/j.poly.2019.114165
Carboxilatos de Hierro
Complejo de Hierro
Estructura cristalina
Hierro
Propiedades magnéticas
-
https://riquim.fq.edu.uy/files/original/b599ab3261e7e6dc6b6d9635e818fe65.pdf
c845c1000b6329c094a98acfecd6b7ea
https://riquim.fq.edu.uy/files/original/2d083bd752599669f042c5adc55ee767.jpg
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Omeka Image File
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8
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3
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155
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New insights into the biophysical behavior of an old molecule: eperimental and theoretical studies of the interaction between 1,10-Phenanthroline and model phospholipid membranes</strong>
Subject
The topic of the resource
BIOFISICA
VESICULAS LIPIDICAS
MOLECULAS
FENANTROLINA
BIBLIOGRAFIA NACIONAL QUIMICA
2022
Abstract
A summary of the resource.
1,10-Phenanthroline, phen, is a molecule with a wide variety of chemical and biological activities, being interesting from a pharmacological standpoint. Its metal complexes have been extensively studied during the last century. Considering the vast applications of phen and its metallic complexes for the development of potential metallodrugs, it becomes of utmost importance to study the molecule’s interaction with diferent molecular targets. So far, in-depth analyses of phen and metal–phen complexes’ interaction with DNA are abundant. Nevertheless, little has been reported on the interaction of this molecule with the frst molecular “target” that it fnds in the cell, the lipid membrane. Here, we present the characterization of the interaction of the phen molecule with model membranes of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) (DPPG) using a combination of diferential scan ning calorimetry and molecular dynamics simulations. Our results indicate that phen difuses into the membranes, being stabilized around the middle of the hydrocarbon chains in DPPC, while in DPPG, it is placed near the center of the bilayer.
Creator
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<a href="https://exportcvuy.anii.org.uy/cv/?e635b6babb330f7d853c44bebf28147f45249ebe02a83f148a2cc7d1d4cfc6eb7c052c905498e0db71ce84c545c5bc262c0c1fa15dd485e385d82024819cf422" target="_blank"><strong>Alvarez, Natalia </strong></a>
<strong>Freddi, Priscilla </strong>
<strong>Castellani, Stephanie </strong>
<a href="https://exportcvuy.anii.org.uy/cv/?5ad3267f4b4cb5190a6d9a3f5877923f528b6603e8a436c2005a31c5f35cd644629532a16ae958823cff6464fe03287baebd3b8724cc14f8d05da74957fe496d" target="_blank"><strong>Veiga, Nicolás </strong></a>
<a href="https://exportcvuy.anii.org.uy/cv/?a41bd5cdd282cee0c5c8be3585cd7593514fcf7fb722e1194e086a5aa98159780502b217d616fd5bb450c02a6152253b7a8957278f35e3a01aabdd446a54f376" target="_blank"><strong>Facchin, Gianella </strong></a>
<strong>Costa Filho, Antonio J. </strong>
Source
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Brazilian Journal of Physicsv. 52, 2022. -- e111
Publisher
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Sociedade Brasileira de Física
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Rights
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<p><span><strong>Información sobre Derechos de Autor</strong></span></p>
<p><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p><strong>La legislación uruguaya protege el derecho de autor</strong><span> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<p><strong>ADVERTENCIA:</strong><span> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</span></p>
Format
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PDF
Language
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Inglés
Type
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Artículo
Identifier
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10.1007/s13538-022-01114-7
Biofísica
Fenantrolina
Moléculas
Vesículas lipídicas
-
https://riquim.fq.edu.uy/files/original/c8dd8f693e23eaa1e1b6848fb10fb667.pdf
ca4efdee8ad348b936c2011ad62e7cca
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Omeka Image File
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Channels
3
Height
155
Width
106
Dublin Core
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New insights into the chemical composition of Baccharis palustris Heering (Asteraceae) essential oil</strong>
Subject
The topic of the resource
BACCHARIS PALUSTRIS
ACEITES ESENCIALES
POLIACETILENOS
BIBLIOGRAFIA NACIONAL QUIMICA
2023
Abstract
A summary of the resource.
B. palustris Heering (Asteraceae), has been previously characterized as having an unusual essential oil composition with C9-/C10-polyacetylenes as main components, and mono- and sesqui terpenes/terpenoids at minor or trace levels. In this work, new insights into the chemical composition of this oil are presented: 1. TLC profiles using different visualization reagents for their characterization, 2. chemical analyses combining HRGC/qMS, HRGC/HRMS-TOF and HRGCxHRGC/HRMS-TOF, and 3. radical scavenging activity assay using the DPPH methodology were performed. The best TLC visualization conditions for the polyacetylenic components of the oil were obtaining using UVλ= 365 nm and vanillin/H3PO4, while the original application of NaDi (1-naphtol + N,N-dimethyl-p-phenylendiamine) demonstrated to be the best option to visualize the lachnophyllum acid methyl esters fraction. Gas chromatography/mass spectrometry protocols allowed the detection of 63 components in B. palustris oil: 39 of them were identified, 6 tentatively assigned without LRI information, and 18 could not be identified. Most of the identified components were mono- and sesquiterpenes and their derivatives. Ten of them are informed for the first time in B. palustris oil [α-pinene epoxide, rosefuran, epi-cubebol, cubebol, germacrene D-4-ol, junenol, epi-α- cadinol, epi-α-muurolol, germacra-4(15),5,10(14)-trien-1-β-ol and oplopanone]. C9-/C10-polyacetylenes (baccharisdyine/lachnophyllum acid derivatives) were confirmed as the main components of the oil, while other polyacetylenes were tentatively identified and their possible structures are discussed. The deconvolution analyses on HRGCxHRGC/HRMS-TOF allowed the identification of a lachnophyllum lactone isomer (undefined stereochemistry), co-eluting with the (cis)-lachnophyllum acid methyl ester peak. Finally, B. palustris oil was found to be an inactive DPPH radical scavenger.
Creator
An entity primarily responsible for making the resource
<strong>Minteguiaga, Manuel</strong>
<strong>Catalán, César Atilio Nazareno</strong>
<strong>Mercado, María Inés</strong>
<strong>Torres, Ana María</strong>
<strong>Ricciardi, Gabriela Ana Leticia</strong>
<strong>Rodríguez Rego, Cecilia</strong>
<strong>Salgar Rangel, William</strong>
<strong>Dellacassa, Eduardo</strong>
<strong>Stashenko, Elena</strong>
Source
A related resource from which the described resource is derived
Brazilian Archives of Biology and Technology v. 66, 2023
Publisher
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Instituto Tecnológico de Paraná
Date
A point or period of time associated with an event in the lifecycle of the resource
2023
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Extent
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17 p.
Language
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Inglés
Type
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Artículo
Identifier
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10.1590/1678-4324-ssbfar-2023230097
Aceites esenciales
Baccharis palustris
Poliacetilenos
-
https://riquim.fq.edu.uy/files/original/ea56cac51993a872d2fd2dd07c26682d.pdf
e178036d9674f251826713e8851bbff2
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Omeka Image File
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3
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213
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
A name given to the resource
<strong>New investigations on copper(II) sebacate : a potentially useful drug for copper supplementation.</strong>
Subject
The topic of the resource
COBRE
FARMACOLOGIA
COMPLEJOS DE COBRE
BIBLIOGRAFIA NACIONAL QUIMICA
1994
Creator
An entity primarily responsible for making the resource
<strong> Barán, Enrique J</strong>
<strong>Etcheverry, S.B</strong>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042"><strong>Torre, María H</strong></a>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=37cace18c8d1da50d33d6bd4f8f1a607"><strong>Kremer, Eduardo</strong></a>
Source
A related resource from which the described resource is derived
Acta Farmacéutica Bonaerense v. 13, no. 2, 1994. -- p. 85-90
Date
A point or period of time associated with an event in the lifecycle of the resource
Colegio de Farmacéuticos de la Provincia de Buenos Aires
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
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Inglés
Type
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Artículo
Identifier
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ISSN: 0326-2383
Cobre
Complejos de cobre
Farmacología
-
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Omeka Image File
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Bit Depth
8
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New isoniazid complexes, promising agents against mycobacterium tuberculosis /</strong>
Subject
The topic of the resource
COMPLEJOS
QUIMICA INORGANICA
TUBERCULOSIS
BIBLIOGRAFIA NACIONAL QUIMICA
2013
Abstract
A summary of the resource.
La tuberculosis (TB) es una enfermedad pública que produce varios millones de muertes anualmente en todo el mundo. Debido a esta crítica situación y a la aparición de cepas resistentes a los fármacos usuales, la investigación de nuevas moléculas para el tratamiento de la TB se ha vuelto una prioridad. En este trabajo se reporta la síntesis y caracterización por análisis elemental, termogravimetría, medidas conductimétricas y espectroscopías UV-Vis, IR y EPR de los complejos [Cu(INH)(H2O)]SO4 ⋅2H2O (Cu-INH) y [CoCl(INH)2(H2O)]Cl⋅2.5H2O (Co-INH) con isoniacida (INH). Por otra parte, se determinó la actividad anti-Mycobacterium tuberculosis (CIMCu-INH = 0.78 µg/mL y CIMCo-INH = 0.19 µg/mL) y la citotoxicidad de los complejos (IC50 = 48.8 and 625 µg/mL respectivamente para los complejos de cobre y cobalto) y se calculó el índice de selectividad (62.5 para Cu-INH y 3205 para Co-INH). Estos resultados indican que estos complejos son buenos candidates para continuar estudios futuros.
Creator
An entity primarily responsible for making the resource
<strong>Poggi, M.</strong>
<strong>Barroso, R.</strong>
<strong>Costa-Filho, A. J.</strong>
<strong>De Barros, H. B.</strong>
<strong>Pavan, F.</strong>
<strong>Leite, C. Q.</strong>
<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>
<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042" target="_blank"><strong>Torre, María H.</strong></a>
Source
A related resource from which the described resource is derived
Journal of Mexican Chemical Society v. 57, no. 3, 2013. -- p. 198-204
Publisher
An entity responsible for making the resource available
Scielo
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
Rights
Information about rights held in and over the resource
<p style="margin-bottom: 0cm;"><strong>Información sobre Derechos de Autor</strong><br /><br />(Por favor lea este aviso antes de abrir los documentos u objetos)<br /><br /><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /><br />(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /><br /><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
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Artículo
Identifier
An unambiguous reference to the resource within a given context
ISSN 1870-249X
Complejos
Química Inorgánica
Tuberculosis
-
https://riquim.fq.edu.uy/files/original/7cc2d109947e68042a5ee0e5bd48f146.pdf
e178036d9674f251826713e8851bbff2
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
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132
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100
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New Limonene-Hybrid Derivatives with Anti-T. cruzi Activity</strong>
Subject
The topic of the resource
ANTIFUNGICOS
ENFERMEDADES PARASITARIAS
TRYPANOSOMA CRUZI
LIMONENO
BIBLIOGRAFIA NACIONAL QUIMICA
2010
Abstract
A summary of the resource.
The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycleframeworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5- nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives.
Creator
An entity primarily responsible for making the resource
<strong>Alvarez, G.</strong>
<strong>Gerpe, Alejandra</strong>
<strong>Benítez, D.</strong>
<strong>Garibotto, F.</strong>
<strong>Zacchino, S.</strong>
<strong>Graebin, C.S.</strong>
<strong>Gomes da Rosa, R.</strong>
<strong>Eifler-Lima, V. L.</strong>
<strong>González, Mercedes</strong>
<strong>Cerecetto, Hugo</strong>
Source
A related resource from which the described resource is derived
Letters in Drug Design and Discovery v. 7, no. 6, 2010. -- p. 452-460
Publisher
An entity responsible for making the resource available
Bentham Science Publishers
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
ISSN 1570-1808
Antifúngicos
Enfermedades parasitarias
Limoneno
Trypanosoma cruzi
-
https://riquim.fq.edu.uy/files/original/77a28c223c1f144144bd3307d6abafc8.pdf
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https://riquim.fq.edu.uy/files/original/444e9e1f68e8d673473cbae95e75d09a.jpg
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
196
Width
155
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
Pdf
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New mechanistic insights into the reversible aldol reaction catalysed by</strong><br /><strong>Rhamnulose-1-phosphate aldolase from Escherichia coli</strong>
Subject
The topic of the resource
ESCHERICHIA COLI
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ANALISIS COMPUTACIONAL
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CATALISIS
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BIBLIOGRAFIA NACIONAL QUIMICA
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2020
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Abstract
A summary of the resource.
<p> </p>
<p>Biocatalysts have emerged as promising tools, with aldolases being among the most employed. Unfortunately, the features of their active sites that modulate the mechanistic details have been poorly assessed. Here, the electronic and structural factors associated with the substrates binding and catalytic mechanism of rhamnulose-<br />1-phosphate aldolase (RhuA) from E. coli are computationally analysed. The results allowed us to furnish a holistic view of the RhuA’s entire turnover cycle. The active site bears three pockets that anchor different moieties of the substrates: L-rhamnulose-1-phosphate (R1P), dihydroxyacetone phosphate (DHAP) and (S)-lactaldehyde (LLA). The results predict a 5-step catalytic mechanism, being the CeC bond breaking (Ea =24.2 kcal mol−1) and the DHAP deprotonation (Ea =22.0 kcal mol−1) the rate-determining steps for the retro- and aldolic<br />reactions, respectively. The residues E117, E171′, G31 and N29, and the Zn2+ cofactor, play a major role in stabilizing the correct substrates’ orientation, securing the stereocontrol at C4. Our findings suggest the presence of two acid/base catalytic residues, E117 and E171′, the latter of which being also involved in assisting the CeC<br />bond formation through a concerted protonation of the transition state.</p>
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Creator
An entity primarily responsible for making the resource
<strong>Rigual, Arquímides J.</strong>
<strong>Cantero, Jorge</strong>
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<strong>Risso, Mariela</strong>
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<strong>Rodríguez, Paula</strong>
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<strong>Rodríguez, Sonia</strong>
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<strong>Paulino, Margot</strong>
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<strong>Gamenara, Daniela</strong>
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<strong>Veiga, Nicolás</strong>
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Source
A related resource from which the described resource is derived
Molecular Catalysis v. 495, 2020. -- p. 1-10.--e 111131
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Publisher
An entity responsible for making the resource available
Elsevier
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Date
A point or period of time associated with an event in the lifecycle of the resource
2020
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Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong> (Por favor lea este aviso antes de abrir los documentos u objetos)<strong> La legislación uruguaya protege el derecho de autor </strong>sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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Format
The file format, physical medium, or dimensions of the resource
Pdf
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Language
A language of the resource
Inglés
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Type
The nature or genre of the resource
Artículo
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Identifier
An unambiguous reference to the resource within a given context
https://doi.org/10.1016/j.mcat.2020.111131
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Analisis computacional
Catálisis
Escherichia coli
-
https://riquim.fq.edu.uy/files/original/92b30353d8cfcd79020cb71e0cc25e62.pdf
e178036d9674f251826713e8851bbff2
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
150
Width
112
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New metabolites from toluene dioxygenase dihydroxilation of oxygenated biphenyls.</strong>
Subject
The topic of the resource
BIOTRANSFORMACION
TOLUENO DIOXIGENASA
METABOLITOS
BIFENILO
BIBLIOGRAFIA NACIONAL QUIMICA
1997
Abstract
A summary of the resource.
Direct microbial oxidation of 2-methoxybiphenyl and 2,3-dimethoxybiphenyl by E. coli JM109 (pDTG601) furnished enantiomerically pure 3-(2-methoxyphenyl)-(1S,2R)-3,5-cyclohexadiene-1,2-diol (2) and 3-(2,3-dimethoxyphenyl)-(1S,2R)-3,5-cyclohexadiene-1,2-diol (3) respectively as the only reaction products. Biphenyl and its mono- and dimethoxy derivatives were subjected to biooxidation with whole cells of E. coli JM109 (pDTG 601). The corresponding diol metabolites were isolated and their absolute stereochemistry determined.
Creator
An entity primarily responsible for making the resource
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=300838f98061f526032e39f0b9df862d"><strong>González, David</strong></a>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=0b6d7b4c1f21766e03e6c9354d672f8d"><strong>Schapiro, Valeria</strong></a>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=502f70a0642a910f5abf0e0d5c853b61"><strong>Seoane, Gustavo</strong></a>
<strong> Hudlicky, T</strong>
Source
A related resource from which the described resource is derived
Tetrahedron Asymmetry v. 8, no. 7, 1997. -- p. 975-977
Publisher
An entity responsible for making the resource available
Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
doi:10.1016/S0957-4166(97)00059-1
Bifenilo
Biotransformación
Metabolitos
Tolueno dioxigenasa
-
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
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150
Width
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https://riquim.fq.edu.uy/files/original/5d648da59f9ecb5aaa527b4f863fdd5d.pdf
0ebebc2e46cd599f97051dd7aefd7031
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New metal complexes of NNO tridentate ligands: Effect of metal center and co-ligand on biological activity</strong>
Subject
The topic of the resource
ANTINEOPLASICOS
COMPLEJOS
METALES
BIOLOGIA
BIBLIOGRAFIA NACIONAL QUIMICA
2014
Abstract
A summary of the resource.
In the search for new agents against Trypanosoma cruzi and cancer the effect of the nature of the metal center and of the presence of a polypiridyl coligand on the antitrypanosomal and antitumoral activities of selected N,N,O ligands [2-(benzothiazol-2-yl-hydrazonomethyl phenol (HL1) and 2-(benzothiazol-2-yl-hydrazonomethyl)-6-methoxyphenol (HL2)] is explored. The new complexes [VVO2(L1)], [VVO2(L2)], [VIVO(L1-H)(phen))] and [GaIII(L2)2](NO3) were synthesized and characterized by using different techniques. The stability of the vanadium complexes in solution was investigated by EPR and 51V NMR spectroscopies and that of the gallium compound by UV–Vis spectroscopy, 1H NMR and conductivity measurements. While the vanadium complexes show high stability in DMSO, the gallium complex shows very good stability in DMSO and moderate stability in aqueous – DMSO medium. <br /><br />The cytotoxicity on human tumor cell lines (ovarian A2780, breast MCF7 and prostate PC3 cell lines) that show different sensitivity to cisplatin was evaluated. All the compounds evidenced antiproliferative activity in the micromolar range. The highest cytotoxic activity, in molar units, is shown by [GaIII(L2)2](NO3) (IC50: 1.7 μM) and [VIVO(L1-H)(phen)] (IC50: 2.7 μM) against the ovarian cancer cells. With the exception of [VVO2(L1)], the cytotoxic activity of the ligands and complexes is similar to that of cisplatin in A2780 cells and surpass cisplatin in the other tumor cells. Regarding the activity on T. cruzi, [VIVO(L1-H)(phen)] showed a 10-fold decrease of IC50 with respect to HL1 and an IC50 value (10.7 μM) in the same order of that of the antitrypanosomal drug Nifurtimox (IC50: 6.0 μM). HL2 showed significant growth inhibitory effect on the parasite (IC50: 23.5 μM) and its coordination to Ga(III) lead to a 2-fold increase in activity in molar units (IC50: 14.2 μM). In order to explain the high inhibitory activity of [VIVO(L1-H)(phen)] against the parasite and the tumor cells, the interaction of this compound with plasmid DNA was preliminarily evaluated by AFM. The corresponding images suggest that DNA may be considered as a potential target.
Creator
An entity primarily responsible for making the resource
<strong>Machado, I.</strong>
<strong>Fernández, M.</strong>
<strong>Becco, L.</strong>
<strong>Garat Bizzozero, Beatriz Maria</strong>
<strong>Brissos, R. F.</strong>
<strong>Zabarska, M</strong>
<strong>Gamez, P.</strong>
<strong>Marques, F.</strong>
<strong>Correia, I.</strong>
<strong>Costa Pessoa, J.</strong>
<a title="currículum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>
Source
A related resource from which the described resource is derived
Inorganica Chimica Acta v. 420, 2014. -- p. 39-46
Publisher
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Elsevier
Date
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2014
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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PDF
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Inglés
Type
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Artículo
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doi:10.1016/j.ica.2013.10.022
Antineoplásicos
Biologia
Complejos
Metales
-
https://riquim.fq.edu.uy/files/original/478e174d6ed40b520cb927f41d7f858a.pdf
c845c1000b6329c094a98acfecd6b7ea
https://riquim.fq.edu.uy/files/original/d2d0080a3e47fd34eb84c465a6d571b4.jpg
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Omeka Image File
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8
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3
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155
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
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Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
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<strong>New multifunctional Ru(II) organometallic compounds show activity against Trypanosoma brucei and Leishmania infantum</strong>
Subject
The topic of the resource
PARASITOS TRIPANOSOMATIDOS
TRYPANOSOMA BRUCEI
LEISHMANIASIS
RUTENIO
BIBLIOGRAFIA NACIONAL QUIMICA
2022
Abstract
A summary of the resource.
Human African trypanosomiasis (sleeping sickness) and leishmaniasis are prevalent zoonotic diseases caused by genomically related trypanosomatid protozoan parasites (Trypanosoma brucei and Leishmania spp). Additionally, both are co-endemic in certain regions of the world. Only a small number of old drugs exist for their treatment, with most of them sharing poor safety, efficacy, and pharmacokinetic profiles. In this work, new multifunctional Ru(II) ferrocenyl compounds were rationally designed as potential agents against these trypanosomatid parasites by including in a single molecule 1,1′ -bis(diphenylphosphino)ferrocene (dppf) and two bioactive bidentate li gands: 8-hydroxyquinoline derivatives (8HQs) and polypyridyl ligands (NN). Three [Ru(8HQs)(dppf)(NN)](PF6) compounds were synthesized and fully characterized. They showed in vitro activity on bloodstream Trypanosoma brucei (IC50 140–310 nM) and on Leishmania infantum promastigotes (IC50 3.0–4.8 μM). The compounds showed good selectivity towards T. brucei in respect to J774 murine macrophages as mammalian cell model (SI 15–38). Changing hexafluorophosphate counterion by chloride led to a three-fold increase in activity on both parasites and to a two to three-fold increase in selectivity towards the pathogens. The compounds affect in vitro at least the targets of the individual bioactive moieties included in the new chemical entities: DNA and generation of ROS. The compounds are stable in solution and are more lipophilic than the free bioactive ligands. No clear correlation between lipophilicity, interaction with DNA or generation of ROS and activity was detected, which agrees with their overall similar anti-trypanosoma potency and selectivity. These compounds are promising candidates for further drug development.
Creator
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<a href="https://export.cvuy.uy/cv/?f5ef40434911dfee97e2be5485a30004e6d60e924764e90565526508d7c4a9668551fcacd53ebb4b1eb636968edea655900b0a79d5deadf21168bb9074273476" target="_blank"><strong>Rivas, Feriannys</strong></a>
<a href="https://export.cvuy.uy/cv/?234d9e55464b427ee1f8c54174a6b189" target="_blank"><strong>Del Mármol, Carolina</strong></a>
<a href="https://export.cvuy.uy/cv/?30f70e9dfd00c43ffab403face2bbb4fd0f8853410743d6fa48798782e4078d5bf0735c77ca026b5828f7194ff3401bbfd4bd422c0ea61fda7a3ceb0a5af09f8" target="_blank"><strong>Scalese, Gonzalo</strong></a>
<strong>Pérez Díaz, Leticia</strong>
<strong>Machado, Ignacio</strong>
<strong>Blacque, Olivier</strong>
<strong>Medeiros Pereyra, Andrea Lourdes</strong>
<strong>Comini, Marcelo</strong>
<a href="https://export.cvuy.uy/cv/?6bb5dcce3e2559101357796ca4a2b2d4c9ba6b3a978a0bd4c5dab0107081b73e1ff46dcf49a7de2b571ff7980c4a01789f09f1d7eac1b879a8553641f940b9a5" target="_blank"><strong>Gambino, Dinorah</strong></a>
Source
A related resource from which the described resource is derived
Journal of Inorganic Biochemistry,v. 237, 2022. -- e112016
Publisher
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Elsevier
Date
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2022
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Extent
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13 p.
Language
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Inglés
Type
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Artículo
Identifier
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10.1016/j.jinorgbio.2022.112016
-
https://riquim.fq.edu.uy/files/original/0f597805b2d799242b356ae3f8831a00.doc
0f4e6b73dad25df0b61ca80a92a78d89
https://riquim.fq.edu.uy/files/original/fd50c811e43f7f9364863518110e4846.gif
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Omeka Image File
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8
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3
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150
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111
Dublin Core
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New Ni (II)- sulfonamide complexes : Synthesis, structural characterization and antibacterial properties. X-ray diffraction of [Ni(sulfisoxazole)2(H2o)4].2H2O and [Ni(sulfapyridine)2]</strong>
Subject
The topic of the resource
SULFONAMIDAS
COMPLEJOS
ANTIINFECCIOSOS
2008
BIBLIOGRAFÍA NACIONAL QUÍMICA
Abstract
A summary of the resource.
The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)2(H2O)4] · 2H2O and [Ni(sulfapyridine)2] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)2(H2O)4] · 2H2O crystallized in a monoclinic system, space group C2/c where the nickel ion was in a slightly distorted octahedral environment, coordinated with two sulfisoxazole molecules through the heterocyclic nitrogen and four water molecules. [Ni(sulfapyridine)2] crystallized in a orthorhombic crystal system, space group Pnab. The nickel ion was in a distorted octahedral environment, coordinated by two aryl amine N from two sulfonamides acting as monodentate ligands and four N atoms (two sulfonamidic N and two heterocyclic N) from two different sulfonamide molecules acting as bidentate ligands. Differential pulse voltammograms were recorded showing irreversible peaks at 1040 and 1070 mV, respectively, attributed to Ni(II)/Ni(III) process. [Ni(sulfisoxazole)2(H2O)4] · 2H2O and [Ni(sulfapyridine)2] presented different antibacterial behavior against Staphylococcus aureus and Escherichia coli from the similar copper complexes and they were inactive against Mycobacterium tuberculosis.
Creator
An entity primarily responsible for making the resource
<strong>Mondelli, Melina</strong>
<strong>Brune, Veronica</strong>
<strong>Borthagaray, Graciela</strong>
<strong>Ellena, Javier</strong>
<strong>Nacimento, Otaciro R.</strong>
<strong>Batista, Alzir A.</strong>
<a title="currículum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042"><strong>Torre, Maria H.</strong></a>
Source
A related resource from which the described resource is derived
Journal of Inorganic Biochemistry v. 102, no. 2, 2008. -- p.285-292
Publisher
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Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
Rights
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<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
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Inglés
Type
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Artículo
Identifier
An unambiguous reference to the resource within a given context
DOI: 10.1016/j.jinorgbio.2007.09.001
Antiinfecciosos
Complejos
Sulfonamidas
-
https://riquim.fq.edu.uy/files/original/e2463ccdf0dac21a9eea318b208ea9da.pdf
055fd9113b5c051fa5a1273c406e5ec6
https://riquim.fq.edu.uy/files/original/07dbc28736a5802dccdacc2f3fc41fc8.jpg
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
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3
Height
155
Width
107
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>New nitric oxide-releasing compounds as promising anti-bladder cancer drugs</strong>
Subject
The topic of the resource
CANCER DE VEJIGA
FUROXANOS
OXIDO NITRICO
BIBLIOGRAFIA NACIONAL QUIMICA
2023
Abstract
A summary of the resource.
Bladder cancer is a worldwide problem and improved therapies are urgently needed. In the search for newer strong antitumor compounds, herein, we present the study of three nitric oxide-releasing compounds and evaluate them as possible therapies for this malignancy. Bladder cancer cell lines T24 and 253J were used to evaluate the antiproliferative, antimigratory, and genotoxic effects of compounds. Moreover, we determined the NF-κB pathway inhibition, and finally, the survivin downregulation exerted by our molecules. The results revealed that compounds 1 and 3 exerted a high antiproliferative activity against bladder cancer cells through DNA damage and survivin downregulation. In addition, compound 3 reduced bladder cancer cell migration. We found that nitric oxide donors are promising molecules for the development of a new therapeutic targeting the underlying mechanisms of tumorigenesis and progression of bladder cancer
Creator
An entity primarily responsible for making the resource
<strong>Varela Vega, María Inés</strong>
<strong>López, Miriam</strong>
<strong>Ingold, Mariana</strong>
<strong>Alem, Diego</strong>
<strong>Perini, Valentina</strong>
<strong>Perelmuter, Karen</strong>
<strong>Bollati Fogolín, Mariela</strong>
<strong>López, Gloria V.</strong>
<strong>Hernández, Paola</strong>
Source
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Biomedicines, v.11, n°1, 2023
Publisher
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MDPI
Date
A point or period of time associated with an event in the lifecycle of the resource
2023
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Extent
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18 p.
Language
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Inglés
Type
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Artículo
Identifier
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10.3390/ biomedicines11010199