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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>Bioorganic and Medicinal Chemistry v. 16, no. 14, 2008. -- p. 6995-7004</text>
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                <text>This study provides insights into the pathogenesis of Ralstonia solanacearum, in particular with regards to strains belonging to phylotype IIB, sequevar 1 (IIB-1) and their interaction with potato, its natural host. We performed a comparative genomic analysis among IIB-1 R. solanacearum strains with different levels of virulence in order to identify candidate virulence genes. With this approach, we identified a 33.7-kb deletion in a strain showing reduced virulence on potato. This region contains a cluster of six genes putatively involved in type IV pili (Tfp) biogenesis. Functional analysis suggests that these proteins contribute to several Tfp-related functions such as twitching motility and biofilm formation. In addition, this genetic cluster was found to contribute to early bacterial wilt pathogenesis and colonization fitness of potato roots.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora. &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp; &amp;nbsp;&amp;nbsp;&lt;/p&gt;</text>
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                <text>The three novel mononuclear copper(II) complexes with dipicolinate and pyridyl-based ligands [Cu(dipic)(L)(OH2)] (L=4-picoline, vinylpyridine, 4-styrylpyridine; dipic2-=dipicolinate) were afforded and structurally characterized. X-ray diffraction studies accounted for slight distorted square-pyramidal structures in which the dianion dipic2- acts as a tridentate ligand in a mer-fashion, the N-donor species occupy an in-plane position, and a water molecule was detected apically coordinated. To assess the effect of the nature of the pyridyl-substituent (para position) on electronic properties, other complexes were also synthesized: [Cu(dipic)(py)(OH2)], [{Cu(dipic)(OH2)}2(&amp;mu;-pyz)] and [{Cu(dipic)(OH2)}(&amp;mu;-pypy){Cu(dipic)}] (py=pyridine, pyz=pyrazine, pypy=(E)-1,2-bis(pyridine-4-yl)ethane). Absorptive behavior in the UV-VIS region was studied in solution and in the solid state (reflectance measurements). Additionally, geometry and population analyses were conducted by means of DFT calculations. Electronic UV-VIS spectra were simulated for both dinuclear complexes in the framework of the TD-DFT methodology to assign the origin of the absorption bands.</text>
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                <text>Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy v. 183, 2017. -- p. 45-52</text>
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&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The title complex, {[Ni(hab)]K[(hab)Ni]}&amp;middot;SCN (H 2 hab is bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminobenzene) crystallizes in the Monoclinic space group P2 1 /c with unit cell dimensions a = 11.5891 (13) &amp;Aring;, b = 17.307 (2) &amp;Aring;, c = 19.781 (2) &amp;Aring;,&amp;beta; = 92.368 (10)&amp;deg;, V = 3964.2 (8) &amp;Aring; 3 , Z = 4, R 1 = 0.106 and wR 2 = 0.305. The Ni II cation is in a N 2 O 2 inner and has a distorted square-planar coordination environment. The Ni II cation is linked by two imino nitrogen atoms and two bridged phenolate oxygen atoms. The potassium cation is octacoordinated in O 8 donor site and linked by four bridged phenolate oxygen atoms and four methoxy oxygen atoms. In the crystal, the {[Ni(hab)]K[(hab)Ni]} + cations form layers parallel to the ab plane. The SCN-anions are located in the interlayer space and connect the layers via C-H&amp;hellip;N and C-H&amp;hellip;S hydrogen bonds, forming three dimensional network.</text>
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                <text>&lt;strong&gt;Diop, Mayoro&lt;/strong&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>The synthesis and structural characterization of the three novel nickel(II) complexes [Ni(OOCPh)2 (mpkoH)2] (1), [Ni(NO3)2(mpkoH)2] (2) and [Ni(mpkoH)3](NO3)2�&amp;frac12;H2O (3�&amp;frac12;H2O), with mpkoH = methyl(2-pyridyl)ketone oxime is reported. Geometry optimization and population analyses were performed by means of DFT calculations for the previously mentioned compounds as well as for [NiCl2 (mpkoH)2] (4). Electronic UV&amp;ndash;vis spectra were also simulated in the TD-DFT framework to assign the origin of the absorption bands and in doing so, to have a clear picture of the absorptive features of the coordination compounds under investigation.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p dir="ltr"&gt;&lt;span&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/span&gt;&lt;/p&gt;&#13;
&lt;p dir="ltr"&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derechode autor&lt;/strong&gt;&lt;span&gt;&amp;nbsp;sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/span&gt;&lt;/p&gt;&#13;
&lt;span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"&gt;&lt;strong&gt;ADVERTENCIA:&lt;/strong&gt;&lt;span&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/span&gt;&lt;/span&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Nitric acid functionalization of carbon monoliths for supercapacitors : Effect on the electrochemical properties&lt;/strong&gt;</text>
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                <text>Activated carbon monoliths and oxidized carbon monoliths are prepared from Eucalyptus grandis wood by pyrolysis and subsequent activation under CO2 (aCMs) and further functionalization using nitric acid (ox-aCMs). Their textural and chemical properties are compared and the electrochemical characteristics as supercapacitor electrodes are tested. The nitric acid treatment does not produce substantial changes in the textural properties of the monolith obtained. Elemental analysis and X-ray photoelectron spectroscopy (XPS) reveal that the oxidized monolith presents a high content of oxygenated functional groups that can participate in pseudocapacitive reactions. This determines that the oxidized monoliths have higher electrical capacitance (80 F cm&amp;minus;3) at low current densities and higher energy density (up to Wv = 2.7 W h L&amp;minus;1) than the non-oxidized ones. The supercapacitor cell containing the oxidized monoliths presents higher total resistance values and response time compared to the non-oxidized monolith. The non-oxidized monolith showed the highest power density (up to PV = 94.5 W L&amp;minus;1).</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_cvuy/exportador/ExportarPdf?hash=cab8f9977cb987eb9dc2b6c5ef5d5d0c" target="_blank"&gt;&lt;strong&gt;Cu&amp;ntilde;a, Andr&amp;eacute;s&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>International Journal of Hydrogen Energy v. 41, 2016. -- p. 12127-12135</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI:10.1016/j.ijhydene.2016.04.169</text>
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                <text>&lt;strong&gt;Nitric oxide and peroxynitrite dependent aconitase inactivation and iron regulatory protein-1 activation in mammalian fibroblasts.&lt;/strong&gt;</text>
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                <text>OXIDO NITRICO</text>
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                <text>The reaction of reactive oxygen and nitrogen species with the [4Fe&amp;ndash;4S]2+cluster of mitochondrial (m-) and cytosolic (c-) aconitases leads to loss of catalytic activity and, in the case of the c-aconitase, triggers total cluster disruption to yield the iron-regulatory protein-1 (IRP-1). Herein we have studied the relative contribution and interplay of reactive oxygen species (O [equation] and H2O2), nitric oxide (&amp;bull;NO), and peroxynitrite in the modulation of m- and c-aconitase and IRP-1 activities in V79-M8 mammalian fibroblasts, identifying key variables that control the various reactivities at the cellular level. Extracellular production of H2O2led to inactivation of both m- and c-aconitase and IRP-1 activation, while extracellular [equation] had no effect. However, increased intracellular production of [equation] caused a loss in m- and c-aconitase activity and IRP-1 activation. Nitric oxide released from NOC-12 had a more complex effect on aconitase and IRP-1 activities. Mitochondrial aconitase was more sensitive than c-aconitase to&amp;bull;NO-mediated inactivation and minimal activation of IRP-1 was observed during a 30-min exposure to the&amp;bull;NO donor. The action of&amp;bull;NO was down- or upregulated by the presence of extra- or intracelular [equation], respectively. Extracellular [equation] decreased the&amp;bull;NO-mediated inactivation of aconitases, due to the preferential extracellular decomposition and the lower diffusivity of peroxynitrite compared to&amp;bull;NO. On the other hand,&amp;bull;NO exposure concomitant with enhanced intracellular [equation] fluxes lead to intracellular peroxynitrite formation as evidenced by Western blot analysis of nitrated proteins, which increased the effects observed with&amp;bull;NO alone. Peroxynitrite-mediated aconitase inactivation, IRP-1 activation, and cellular protein nitration were more pronounced in cells with low GSH content such as V79-M8 glutathione-depleted cells as well as in pGSOD4 cells which contain 32% of the GSH of the parental strain. Mechanistically, our results imply that the differential actions of the studied reactive species toward cellular aconitases depend on at least three critical factors: (i) their reaction rates with aconitases, (ii) the cellular compartment where they are formed, and (iii) the intracellular status of glutathione.</text>
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                <text>&lt;strong&gt;Castro, L. A&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Robalinho, R.L&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Meneghini, R&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Radi, Rafael&lt;/strong&gt;</text>
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                <text>Archives of Biochemistry and Biophysics v. 359, no. 2, 1998. -- p. 215-224</text>
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              <elementText elementTextId="320538">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora</text>
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                <text>The competition between selected or commercial killer strains of type K2 and sensitive commercial strains of Saccharomyces cerevisiae was studied under various conditions in sterile grape juice fermentations. The focus of this study was the effect of yeast inoculation levels and the role of assimilable nitrogen nutrition on killer activity. A study of the consumption of free amino nitrogen (FAN) by pure and mixed cultures of killer and sensitive cells showed no differences between the profiles of nitrogen assimilation in all cases, and FAN was practically depleted in the first 2 days of fermentation. The effect of the addition of assimilable nitrogen and the size of inoculum was examined in mixed killer and sensitive strain competitions. Stuck and sluggish wine fermentations were observed to depend on nitrogen availability when the ratio of killer to sensitive cells was low (1:10 to 1:100). A relationship between the initial assimilable nitrogen content of must and the proportion of killer cells during fermentation was shown. An indirect relationship was found between inoculum size and the percentage of killer cells: a smaller inoculum resulted in a higher proportion of killer cells in grape juice fermentations. In all cases, wines obtained with pure-culture fermentations were preferred to mixed-culture fermentations by sensory analysis. The reasons why killer cells do not finish fermentation under competitive conditions with sensitive cells are discussed.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
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                <text>&lt;p&gt;La enfermedad de Alzheimer (EA) es la forma m&amp;aacute;s com&amp;uacute;n de demencia en el mundo, con alrededor de 47.5 millones de personas afectadas. Actualmente no existe cura y los &amp;uacute;nicos f&amp;aacute;rmacos aprobados para su tratamiento tienen como efecto una mejora transitoria de los s&amp;iacute;ntomas de la enfermedad, pero no son capaces de revertir o detener el da&amp;ntilde;o neuronal asociado. Esto se debe a que los procesos bioqu&amp;iacute;micos que desencadenan la enfermedad a&amp;uacute;n se desconocen. Un rasgo distintivo y com&amp;uacute;n en los procesos neurodegenerativos es el aumento intracelular de especies reactivas del ox&amp;iacute;geno y del nitr&amp;oacute;geno, lo que desencadena una serie de eventos que conducen a la apoptosis.&lt;/p&gt;&#13;
&lt;p&gt;La enzima caspasa-3 ha sido identificada como un blanco terap&amp;eacute;utico interesante, ya que la misma no s&amp;oacute;lo act&amp;uacute;a como un mediador clave en la apoptosis neuronal, sino que tambi&amp;eacute;n participa en procesos no apopt&amp;oacute;ticos mediante la formaci&amp;oacute;n de fragmentos t&amp;oacute;xicos de prote&amp;iacute;nas espec&amp;iacute;ficas que afectan la sinapsis y la plasticidad neuronal en etapas tempranas de la EA. Se ha observado que la caspasa-3 no s&amp;oacute;lo se activa selectivamente en c&amp;eacute;lulas de hipocampo de ratones transg&amp;eacute;nicos modelo de EA alterando la funci&amp;oacute;n sin&amp;aacute;ptica que da inicio a la p&amp;eacute;rdida de memoria, sino que tambi&amp;eacute;n en cerebros de pacientes con EA existen niveles elevados de esta enzima.&lt;/p&gt;&#13;
&lt;p&gt;En la b&amp;uacute;squeda de nuevos agentes terap&amp;eacute;uticos capaces de modular la sobreactivaci&amp;oacute;n de caspasa-3, nuestro grupo de investigaci&amp;oacute;n se ha enfocado en el desarrollo de inhibidores reversibles y selectivos de caspasa-3 evidenciando que aquellos compuestos derivados de tiazol y nitrona (imina N-&amp;oacute;xido) son buenos inhibidores de caspasa-3 y presentan elevada capacidad antioxidante. En base a estos antecedentes, en el presente trabajo se realiz&amp;oacute; la s&amp;iacute;ntesis de nuevas mol&amp;eacute;culas h&amp;iacute;bridas conteniendo agrupamientos nitrona y tiazol dise&amp;ntilde;adas para potenciar la selectividad y actividad inhibitoria frente a caspasa-3. Se determin&amp;oacute; el efecto neuroprotector antioxidante, antiapopt&amp;oacute;tico, la capacidad inhibitoria frente a caspasa-3 y caspasa-7 in vitro y se realizaron estudios te&amp;oacute;ricos de docking y din&amp;aacute;mica molecular para estudiar la interacci&amp;oacute;n a nivel at&amp;oacute;mico de los compuestos en la caspasa-3 y caspasa-7. Los resultados obtenidos muestran que los compuestos evaluados son excelentes agentes antioxidantes y antiapopt&amp;oacute;ticos, y moderados inhibidores de caspasa-3. El an&amp;aacute;lisis te&amp;oacute;rico indica que los derivados se unen en la zona de la interfase cercano al sitio alost&amp;eacute;rico interaccionando con residuos clave para mantener la conformaci&amp;oacute;n activa de la enzima caspasa-3 y con menor afinidad en caspasa-7. Las nitronas a4 y a6 presentan muy buena actividad neuroprotectora e inhiben al menos un 20% la actividad caspasa-3. Esto las posiciona como nuevos hits para el redise&amp;ntilde;o y desarrollo de futuros potenciales f&amp;aacute;rmacos contra EA y otras enfermedades neurodegenerativas.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Cancela, Saira&lt;/strong&gt;</text>
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                <text>Montevideo : UdelaR-Facultad de Qu&amp;iacute;mica</text>
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                <text>&lt;p&gt;Merlino, Alicia.&amp;nbsp;(Directora de Tesis)&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;/p&gt;</text>
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                <text>Lavaggi, Mar&amp;iacute;a Laura.&amp;nbsp;(Directora de Tesis)&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; &lt;strong&gt;de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA:&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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