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                <text>Cambio. A&amp;ntilde;o VI N&amp;ordm; 8 Agosto 2000</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Tannat is a red variety of Vitis vinifera that has become the emblematic red wine variety of Uruguay. Tannat wine is characterized by its high total phenolic content, which provides a good potential for aging and differential sensory characteristics. The aim of the present thesis was to characterize the astringency of Uruguayan Tannat wines from both a physicochemical and sensory perspective. Astringency is a complex and timedependent attribute, which exhibits buildup and carry over effects upon repeated ingestions, and is related to several subtle sensations that can be perceived simultaneously. This poses several challenges for the accurate sensory characterization of Tannat wine astringency, which have been addressed during the development of the thesis. First, qualitative studies with consumers were carried out to understand their conceptualization of astringency and the vocabulary they use for describing this complex attribute. Basic research about the applicability of different palate cleansers for wine astringency evaluation was also conducted. The astringency of 40 commercial wines was characterized using static and dynamic sensory methods: Time-Intensity (TI), checkall- that-apply (CATA) questions and Temporal Dominance of Sensations (TDS). The TI evaluations performed by a panel of trained assessors showed that commercial Tannat wines mainly differed in intensity-related parameters rather than in astringency development over time, although the variability was moderate. CATA questions involving 16 astringency sub-qualities proved to be a valuable tool to describe and differentiate a large sample set of Tannat wine samples based on their astringency characteristics. Different styles of Tannat wine were identified, which were described using a wide range of sub-qualities, from silky and velvety to harsh and aggressive. The phenolic profile of the 40 commercial Tannat wines was also characterized using reversed phase high performance liquid chromatography coupled with a mass spectrometer (HPLC-MS) and its relationship with sensory astringency was explored using boosted regression trees. The total content of condensed tannins as well and some specific phenolic compounds were identified as the main predictors of sensory astringency. Finally, the comparison of astringency evaluation of trained assessors and experts showed that their intensity assessments were partly related, but their description of astringency sub-qualities differed. Insights on the astringency sub-qualities related to expert&amp;rsquo;s perception of astringency quality were also revealed. Results from the thesis provide both methodological insights about astringency evaluation, as well as applied information about the astringency of Tannat wine, which could be highly valuable for the Uruguayan</text>
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                <text>&lt;strong&gt;Vidal, Leticia.&lt;/strong&gt;</text>
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The regio- and stereochemistry of electrophile-promoted transannular ring expansion of cyclo 1,5- and 1,6-epoxyalkenes and cyclo trans-1,5-bisepoxides were studied. The results are rationalized in terms of tricyclic oxonium intermediates showing the directing ability of oxygen substituents in the regio- and stereocontrol observed.</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
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                <text>Quantitative structure-activity relationships were performed on a set of 5-nitrofuran derivatives. The correlation parameters used were hydrophobicity and connectivity. The former was measured by means of the capacity factor (log k o &amp;prime; ) obtained by HPLC and the latter through the molecular valence connectivity index1&amp;chi;v obtained by computational methods. The biological activity data considered were growth inhibition percentages ofT. cruzi (GI % (48 h)) and half-maximal inhibitory concentration of Glutathione Reductase (I0.5 (max)). Good adjustment, r=0.98, was obtained if a logarithmic model is used for I0.5 (max) correlations. When GI% is considered, correlations were poorer and the consideration of both structural parameters was necessary for their improvement, r=0.94.</text>
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                <text>Los inhibidores pept&amp;iacute;dicos de la enzima convertidora de angiotensina-I (ECA-I) son muy interesantes por ser compuestos naturales con efecto antihipertensivo. Muchos p&amp;eacute;ptidos bioactivos han sido obtenidos por hidr&amp;oacute;lisis enzim&amp;aacute;tica de prote&amp;iacute;nas alimentarias y las prote&amp;iacute;nas l&amp;aacute;cteas han tenido un papel destacado. Sin embargo, las peptidasas empleadas han sido fundamentalmente enzimas comerciales de origen animal o microbiano. El uso de peptidasas de plantas, obtenidas de fuentes menos convencionales, podr&amp;iacute;a liberar nuevos p&amp;eacute;ptidos inhibidores de ECA-I o aquellos que se sabe forman parte de la secuencia de las prote&amp;iacute;nas del LS pero que a&amp;uacute;n no han sido liberados con las enzimas cl&amp;aacute;sicas. Las peptidasas de una especie de Bromeli&amp;aacute;cea aut&amp;oacute;ctona, recientemente caracterizadas por nuestro grupo de investigaci&amp;oacute;n, presentan caracter&amp;iacute;sticas interesantes para la hidr&amp;oacute;lisis del LS y a&amp;uacute;n no han sido utilizadas para la preparaci&amp;oacute;n in vitro de hidrolizados de prote&amp;iacute;nas. En este sentido, se estudi&amp;oacute; el potencial de las peptidasas de Bromelia antiacantha Bertol., para hidrolizar el LS y evaluar la actividad inhibidora de la ECA-I. Demostramos que las peptidasas de B. antiacantha fueron capaces de hidrolizar a las prote&amp;iacute;nas del LS con un importante efecto del pH de reacci&amp;oacute;n para modificar la susceptibilidad de hidr&amp;oacute;lisis de &amp;alpha;-lactalbumina (ALA) y &amp;beta;-lactoglobulina (BLG), las prote&amp;iacute;nas mayoritarias del LS. Se obtuvieron hidrolizados de LS, ALA y BLG con potente actividad inhibitoria de ECA-I. En todos los casos, la fracci&amp;oacute;n pept&amp;iacute;dica de tama&amp;ntilde;o menor a 2 kDa present&amp;oacute; una actividad inhibitoria de ECA-I potente y esta fue resistente a un proceso de digesti&amp;oacute;n gastrointestinal simulado in vitro. A partir del hidrolizado de ALA se capturaron por cromatograf&amp;iacute;a de afinidad y posteriormente se identificaron por espectrofotometr&amp;iacute;a de masas dos nuevos p&amp;eacute;ptidos derivados de ALA con actividad inhibitoria de ECA-I. A partir de estudios de cin&amp;eacute;tica de inhibici&amp;oacute;n de ECA-I fue posible establecer que el p&amp;eacute;ptido Thr-Thr-Phe-His-Thr-Ser-Gly-Tyr (TTFHTSGY) se comport&amp;oacute; como un inhibidor total, mientras que el p&amp;eacute;ptido Gly-Tyr-Asp-Thr-Gln-Ala-Ile-Val-Gln (GYDTQAIVQ) fue capaz de inhibir parcialmente a ECA-I y a concentraciones elevadas de inhibidor por lo que no se continu&amp;oacute; su caracterizaci&amp;oacute;n. Sin embargo, hay dos secuencias con actividad inhibitoria de ECA-I reportada encriptadas en el p&amp;eacute;ptido GYDTQAIVQ (GY e IVQ) que podr&amp;iacute;an ser liberadas durante su digesti&amp;oacute;n gastrointestinal, convirti&amp;eacute;ndolo en productos potencialmente m&amp;aacute;s activos in vivo. TTFHTSGY mostr&amp;oacute; una cin&amp;eacute;tica de inhibici&amp;oacute;n compatible con un inhibidor competitivo. Los valores de las constantes de inhibici&amp;oacute;n hallados indicaron que se tratar&amp;iacute;a de inhibidores reversibles competitivos cl&amp;aacute;sicos</text>
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                <text>&lt;strong&gt;Villad&amp;oacute;niga, Carolina.&lt;/strong&gt;</text>
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                <text>Montevideo: UdelaR-Facultad de Qu&amp;iacute;mica</text>
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                <text>&lt;strong&gt;Cantera,Ana Maria B.&lt;/strong&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Espa&amp;ntilde;ol</text>
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                <text>577.1 VILL</text>
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        <name>Peptidasas</name>
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        <name>Péptidos bioactivos</name>
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                  <text>Bibliografía Nacional Química</text>
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                <text>&lt;strong&gt;Influence of intrinsic and extrinsic factors on consumer liking and wellbeing perception of two regular and probiotic milk products&lt;/strong&gt;</text>
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                <text>LECHE</text>
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                <text>PROBIOTICOS</text>
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                <text>COMPORTAMIENTO DEL CONSUMIDOR</text>
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                <text>The aim of the study was to evaluate the influence of intrinsic and extrinsic characteristics of the regular and probiotic version of two milk products on consumer overall liking and perceived wellbeing. In Study 1, consumers evaluated milk samples with different label design. In Study 2, consumers evaluated samples of chocolate flavored milk differing in sugar content and nutrition information. In both studies, consumers rated their overall liking and completed a check-all-thatapply question composed of expressions related to different dimensions of wellbeing. Overall liking scores were significantly affected by the sensory characteristics of samples but not by the characteristics of the labels. In Study 2, the highest average overall liking scores were found for samples with high sugar content (6.2 vs. 6.0). The frequency with which consumers used some of the wellbeing terms was influenced by both intrinsic and extrinsic variables. In Study 1, the term &amp;ldquo;It is nutritious&amp;rdquo; was significantly more used to described probiotic milk compared to regular milk. In Study 2, sugar content and the information included on the labels influenced the frequency of use of terms related to physical and psychological wellbeing, such as &amp;ldquo;It is good for wellbeing&amp;rdquo; and &amp;ldquo;It makes me feel guilty.&amp;rdquo; Practical applications Although hedonic aspects of food consumption are major determinants of consumer food choices, results from the present work showed that consumer perceived wellbeing enabled the discrimination of samples that did not significantly differ in their overall liking scores. This suggests that wellbeing measurements can provide complementary information about consumer perception of food products to overall liking scores.</text>
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                <text>&lt;strong&gt;Oliveira, Denize&lt;/strong&gt;</text>
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                <text>&lt;a title="Curr&amp;iacute;culum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=358965ab1701bacbb43e4f5a24a8e876" target="_blank"&gt;&lt;strong&gt;Gast&amp;oacute;n, Ares&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Deliza, Rosires&lt;/strong&gt;</text>
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                <text>Journal of Sensory Studies v. 32, no, 3, 2017. -- p. 1-9.--e.12261</text>
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                <text>Wiley</text>
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              <elementText elementTextId="467178">
                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>DOI: 10.1111/joss.12261</text>
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                  <text>Bibliografía Nacional Química</text>
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                <text>Projective mapping (PM), one of the most holistic product profiling methods in approach, is increasingly being used to uncover consumers' perception of products and packages. Assessors rely on a process of synthesis for evaluating product information, which would determine the relative importance of the perceived characteristics they use for mapping them. Individual differences are expected, as participants are not instructed on the characteristics to consider for evaluating the degree of difference among samples, generating different perceptual spaces. Individual differences in cognitive style can affect synthesis processes and thus their perception of similarities and differences among samples. In this study, the influence of the cognitive style in the results of PM was explored. Two consumer studies were performed, one aimed at describing intrinsic sensory characteristics of chocolate flavoured milk and the other one looking into extrinsic (package only) of blueberry yogurts. Consumers completed the wholistic-analytic module of the extended Verbal Imagery Cognitive Styles Test &amp;amp; Extended Cognitive Style Analysis-Wholistic Analytic Test, to characterize their cognitive style. Differences between wholistic and analytic consumers in how they evaluated samples using projective mapping were found in both studies. Analytics separated the samples more in the PM perceptual space than wholistic consumers, showing more discriminating abilities. This may come from a deeper analysis of the samples, both from intrinsic and extrinsic point of views. From a sensory perspective (intrinsic), analytic consumers relied on more sensory characteristics, while wholistic mainly discriminated samples according to sweetness and bitterness/chocolate flavour. In the extrinsic study however, even if analytic consumers discriminated more between packs, they described the products using similar words in the descriptive step. One important recommendation coming from this study is the need to consider higher dimensions in the interpretation of projective mapping tasks, as the first dimensions could underestimate the complexity of the perceptual space; currently, most applications of PM consider two dimensions only, which may not uncover the perception of specific groups of consumers.</text>
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                <text>&lt;strong&gt;Vidal, Leticia.&lt;/strong&gt;</text>
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                <text>Food Research International v. 99, 2017. -- p. 693-70101</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>DOI:10.1016/j.foodres.2017.06.021</text>
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        <name>Comportamiento  del consumidor</name>
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        <name>Mapeo proyectivo</name>
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                  <text>Bibliografía Nacional Química</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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                <text>&lt;strong&gt;Trypanothione reductase : A target for the development of anti-Trypanosoma cruzi drugs&lt;/strong&gt;</text>
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          <element elementId="49">
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            <description>The topic of the resource</description>
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                <text>ANTIPARASITARIOS</text>
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                <text>PRODUCTOS FARMACEUTICOS</text>
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                <text>ANTITRIPANOSOMAS</text>
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          <element elementId="87">
            <name>Abstract</name>
            <description>A summary of the resource.</description>
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              <elementText elementTextId="467531">
                <text>Background &amp;amp; Objective: Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi. Conclusion: In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.</text>
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                <text>&lt;strong&gt;V&amp;aacute;zquez, K.&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2e3c62395a54ce79c86b7e4fa4b5c3f9" target="_blank"&gt;&lt;strong&gt;Paulino, Margot.&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Salas, C. O.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Zarate-Ramos, J.J&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Vera, B.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rivera, G.&lt;/strong&gt;</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="467538">
                <text>Mini-Reviews in Medicinal Chemistry v. 17, no. 11, 2017. -- p. 939-946</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="467539">
                <text>Ingenta</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2017</text>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="467541">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.2174/1389557517666170315145410</text>
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                  <text>Tesis de doctorado, maestría, trabajos de diploma y monografías técnicas</text>
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                  <text>Versiones electrónicas de las tesis de doctorado, maestría y trabajos de diploma de la Facultad de Química, Universidad de la República (UdelaR).&#13;
Incluye únicamente trabajos hasta el año 2023. Los trabajos posteriores se encuentran disponibles en el Repositorio Colibrí.</text>
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                  <text>Departamento de Documentación y Biblioteca</text>
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                <text>&lt;strong&gt;Desarrollo y evaluaci&amp;oacute;n de radiotrazadoresw para el estudio y diagn&amp;oacute;stico precoz de gliopat&amp;iacute;as en la enfermedad de Alzheimer mediante tomograf&amp;iacute;a por emisi&amp;oacute;n de positrones&lt;/strong&gt;</text>
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                <text>Kreimerman Franco, Ingrid</text>
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                <text>Montevideo: UdelaR-Facultad de Química</text>
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                <text>&lt;strong&gt;Savio, Eduardo&lt;/strong&gt; (director de tesis)</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="467558">
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                <text>&lt;strong&gt;C&amp;aacute;ncer de mama y ovario hereditario en Uruguay : resultados del screening para mutaciones en genes de susceptibilidad por secuenciaci&amp;oacute;n de nueva generaci&amp;oacute;n&lt;/strong&gt;</text>
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                <text>Introducci&amp;oacute;n: el c&amp;aacute;ncer de mama representa la primera causa de muerte por c&amp;aacute;ncer en mujeres de Uruguay. Se estima que cerca de 7% son causados por mutaciones en el &amp;aacute;cido desoxirribonucleico germinal. Los costos de la secuenciaci&amp;oacute;n gen&amp;eacute;tica han descendido dram&amp;aacute;ticamente gracias a la aparici&amp;oacute;n de la secuenciaci&amp;oacute;n de nueva generaci&amp;oacute;n (NGS). El cambio tecnol&amp;oacute;gico abri&amp;oacute; una nueva etapa en el estudio del c&amp;aacute;ncer hereditario en nuestro pa&amp;iacute;s. Objetivo: comunicar los resultados de la utilizaci&amp;oacute;n de tecnolog&amp;iacute;a NGS y paneles multig&amp;eacute;nicos en familias uruguayas con alto riesgo de c&amp;aacute;ncer de mama hereditario. Pacientes y m&amp;eacute;todo: se secuenciaron 135 familias de alto riesgo que proven&amp;iacute;an de la consulta de consejer&amp;iacute;a gen&amp;eacute;tica que funciona en el Grupo Colaborativo Uruguayo: Investigaci&amp;oacute;n de afecciones oncol&amp;oacute;gicas hereditarias. Cuando la historia familiar suger&amp;iacute;a claramente un s&amp;iacute;ndrome de c&amp;aacute;ncer de mama y ovario hereditario se efectu&amp;oacute; secuenciaci&amp;oacute;n NGS exclusiva de los genes BRCA1 y 2; cuando el patr&amp;oacute;n familiar no configuraba claramente se utiliz&amp;oacute; un panel multig&amp;eacute;nico. Resultados: se efectu&amp;oacute; NGS exclusiva de genes BRCA1 y 2 en 62 familias y un panel multig&amp;eacute;nico en 73 familias. Se identificaron en total 29 mutaciones pat&amp;oacute;genas (21 en genes BRCA y 8 en otros genes). Dos de ellas fueron noveles y tres pueden considerarse recurrentes en la poblaci&amp;oacute;n uruguaya. Conclusiones: este trabajo es el primero en Uruguay en reportar el resultado de esta nueva tecnolog&amp;iacute;a en el c&amp;aacute;ncer de mama hereditario. El hallazgo de 29 mutaciones pat&amp;oacute;genas nos ayuda a delinear el perfil mutacional de nuestro pa&amp;iacute;s. C&amp;aacute;ncer de mama y ovario hereditario en Uruguay: resultados del screening para mutaciones en genes de susceptibilidad por secuenciaci&amp;oacute;n de nueva generaci&amp;oacute;n.</text>
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                <text>Revista M&amp;eacute;dica del Uruguay&amp;nbsp; v. 33, no. 2, 2017. -- p. 97-102</text>
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                <text>Tetrahedron: Asymmetry v. 28, 2017. -- p. 344-348</text>
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                <text>&lt;strong&gt;Activity of the Calcineurin Pathway in Patients on the Liver Transplantation Waiting List :&amp;nbsp; Factors of Variability and Response to Tacrolimus Inhibition&lt;/strong&gt;</text>
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                <text>BACKGROUND: We sought to evaluate, in patients on a liver transplantation waiting list, potential biomarkers of the base calcineurin pathway activity with use of a new model of nonstimulated peripheral blood mononuclear cells (PBMC) and ex vivo response to tacrolimus (TAC). METHODS: The calcineurin pathway activity was explored ex vivo in stimulated and nonstimulated PBMC from 19 patients. The inhibition of NFAT1 translocation to PBMC nuclei, expression of intracellular IL-2, and membrane CD25 in different T-cell subsets were measured by multiparametric flow cytometry before and after exposure to TAC. We also studied the influence on the individual response of polymorphisms in 3 key genes of the calcineurin pathway: PPIA, PPP3CA, and IL2RA. RESULTS: All pharmacodynamics profiles closely fitted an I/Imax sigmoid model. Interindividual variability was higher in nonstimulated than in stimulated conditions, as well as in the presence of TAC. IL-2+CD8+ cells at TAC Imax showed the highest interindividual variability, suggesting its usefulness as a biomarker of individual TAC effects integrating many different sources of regulation and variability. Moreover, in the absence of TAC, patients with end-stage liver disease exhibited lower NFAT1 translocation and T-cell activation than healthy volunteers from a previous study under similar conditions. Multivariate statistical analysis showed strong and significant associations between TAC pharmacodynamic parameters and 2 polymorphisms in the gene-coding cyclophilin A (rs8177826 and rs6850). CONCLUSIONS: We show the feasibility of using nonstimulated PBMCs to explore the calcineurin pathway under more physiologic conditions and point toward potential biomarkers for TAC pharmacodynamic monitoring.</text>
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                <text>v. 63, no. 11, 2017. -- p. 1734-1744</text>
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                <text>American Association for Clinical Chemistry</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The enantioselective preparation of three protected &amp;beta;-amino- &amp;gamma; -hydroxyesters from benzoic acid is described. The employed synthetic methodology involves the ipso, ortho cis-dihydroxylation of benzoic acid by the mutant strain Ralstonia eutropha B9, followed by a selective halonium induced beta lactamization. Modification of this novel &amp;beta;-lactam structure by the appropriate sequence of reactions allows for the selective preparation of the aforementioned &amp;beta; -amino- &amp;gamma; -hydroxyesters in a diastereodivergent manner. The overall transformation results in a selective formal aminohydroxylation of the diene moiety of the initial cis-cyclohexadienediol. The synthesized products are important building blocks and will allow for the selective preparation of aminoacids, inosamines and alkaloids from benzoic acid.</text>
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                <text>Tetrahedron Letters v. 58, 2017. -- p. 2182-2185</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Tinta para imprenta&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;IMPRESION (ARTES GRAFICAS)&lt;/strong&gt;</text>
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            <name>Publisher</name>
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                <text>Espa&amp;ntilde;ol</text>
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          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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            <description>A language of the resource</description>
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                <text>Espa&amp;ntilde;ol</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Bibliograf&amp;iacute;a</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Biblioteca-FQ</text>
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                <text>Biblioteca-FQ</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>Papel</text>
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            <name>Language</name>
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                <text>Espa&amp;ntilde;ol</text>
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            <description>Temporal characteristics of the resource.</description>
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            <name>Title</name>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Biblioteca-FQ</text>
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            <description>The file format, physical medium, or dimensions of the resource</description>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>Espa&amp;ntilde;ol</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Bibliograf&amp;iacute;a</text>
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          <element elementId="116">
            <name>Temporal Coverage</name>
            <description>Temporal characteristics of the resource.</description>
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                <text>1956-1984</text>
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        <name>Fertilizantes</name>
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        <name>Hidroponia</name>
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