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                <text>&lt;strong&gt;Parenthood as a window of opportunity for dietary changes : perspectives from uruguayan parents&lt;/strong&gt;</text>
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                <text>Research on behavioral and social science has demonstrated that transitions throughout a person&amp;rsquo;s life course, as the life event of becoming a parent, represent an opportunity for dietary changes. However, research in this area has been mostly restricted to developed European and North American countries and has shown ambiguous results. The present work aimed to gain an in-depth understanding on the changes in eating habits caused by the transition to parenthood and to explore factors influencing those changes in Uruguay, a Latin American country. Forty-two in-depth interviews with Uruguayan parents from diverse social-economic backgrounds were conducted. The narrations by the interviewees evidenced mostly positive changes during three stages in the transition: pregnancy, the first months with the baby, and the beginning of complementary feeding. Most informants perceived changes mainly in terms of increased consumption of fruits, vegetables, and pulses; increased consumption of homemade meals; and decreased consumption of ultra-processed foods, fast foods, and fried foods. Reasons for these changes included adaptation of meals to the child&amp;rsquo;s needs and schedule, feeling of responsibility for the child&amp;rsquo;s health, and willingness to be a good role model. Factors influencing changes in eating habits were identified in some levels of the socioecological model and included socioeconomic status; price of fruits, vegetables, and fish; low accessibility of good quality fish; perceived time pressure; father&amp;rsquo;s low interest on healthy eating; social support; and access to nutrition information. Findings suggest that parenthood represents a window of opportunity for favorable changes in eating habits. However, barriers constraining those changes should be addressed by stakeholders.</text>
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                <text>&lt;strong&gt;Ferreira Moura, Andreia&lt;/strong&gt;</text>
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                <text>Health Education and Behavior, v.50, n&amp;deg;1, 2022</text>
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                <text>&lt;div&gt;Society for Public Health Education&lt;/div&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Parents&amp;rsquo; mental associations with ultra-processed products for their infant children:&amp;nbsp;insights to improve complementary feeding practices&lt;/strong&gt;</text>
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                <text>ASOCIACION DE PALABRAS</text>
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                <text>&lt;p&gt;Increasing consumption of ultra-processed products from early age has raised growing concerns. In this context, the aims of the present work were: i) to explore the automatic mental associations raised by packages of ultra-processed products among parents of children under 12 months of age, ii) to estimate the valence of the affective reactions elicited by ultra-processed products, and iii) to explore the influence of socio-demographic variables and feeding styles on the valence of parents&amp;rsquo; associations with ultra-processed products. A total of 419 parents of children under 12 months of age were recruited at 20 health facilities that offer well-child services, selected using probability proportional to size sampling based on the number of births at each institution. Participants were presented with the labels of six ultra-processed products (corn snack, frankfurters, milk dessert, orange juice, wafer cookies, yogurt) and were asked to indicate the first words that came to their mind. The products raised mixed mental associations, which were mainly related to pleasure and health. Responses from the majority of participants (61&amp;ndash;82%) evidenced negative associations with corn snacks, frankfurters and wafer cookies, whereas responses from 35 to 45% of the participants suggested a positive affective reaction towards orange juice, milk dessert and yogurt. Likelihood of having a positive affective reaction towards the evaluated ultra-processed products was higher for parents of 1 to 4 months infants, as well as those from low educational level and low socio-economic status. In addition, beliefs about three feeding practices (restriction on diet quality, indulgence in screen use and pressure for finishing) significantly influenced the valence of the associations. Results from the present work suggest the need to implement regulatory measures to reduce positive associations with ultra-processed products among parents and contribute to reduce their consumption among infants.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Vidal, Leticia&lt;/strong&gt;</text>
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                <text>&lt;a href="https://siteanii.anii.org.uy/upcms/files/isabel-bove.pdf"&gt;&lt;strong&gt;Bove, Isabel&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Food Quality and Preference&amp;nbsp;v.94, 2021. -- e104335</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&amp;nbsp;protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;em&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;&lt;/em&gt;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Sodium reduction strategies that fully or partially compensate for the effect of reducing sodium on the sensoy profile of foods have been proposed as a cost‐effective alternative to decrease dietary sodium intake at the population level. The present work aimed at exploring the effect of partially replacing NaCl with KCl on the sensory characteristics and hedonic perception of toast bread. Equivalent salty concentration of NaCl : KCl blends were estimated relative to different NaCl concentrations, using paired comparisons with a panel of trained assessors. The influence of partially replacing NaCl by KCl on the dynamic sensory profile of toast breads was assessed using the Temporal Check‐all‐that‐apply approach with a trained panel. Finally, a consumer study was carried out to evaluate consumers' sensory and hedonic perception of toast breads produced by partially replacing 30% NaCl with KCl. Results from the present work suggest that KCl can be deemed effective at compensating for saltiness intensity in sodium reduced toast breads. Partial replacement of 30% NaCl with KCl did not significantly affect the sensory characteristics of toast breads. However, NaCl replacement equal or higher than 40% caused an increase in bitterness, off‐flavor, and metallic flavor. Heterogeneity in consumer hedonic reaction toward partial replacement of NaCl with KCl was observed, but mainly associated to differences in texture perception.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Particles from the Echinococcus granulosus Laminated Layer Inhibit CD40 Upregulation in Dendritic Cells by Interfering with Akt Activation&lt;/strong&gt;</text>
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                <text>The larval stage of the cestode Echinococcus granulosus causes cystic echinococcosis in humans and livestock. This larva is protected by the millimeter-thick, mucin-based laminated layer (LL), from which materials have to be shed to allow parasite growth. We previously reported that dendritic cells (DCs) respond to microscopic pieces of the mucin gel of the LL (pLL) with unconventional maturation phenotypes, in the absence or presence of Toll-like receptor (TLR) agonists, including lipopolysaccharide (LPS). We also reported that the presence of pLL inhibited the activating phosphorylation of the phosphatidylinositol 3-kinase (PI3K) effector Akt induced by granulocyte-macrophage colony-stimulating factor or interleukin-4. We now show that the inhibitory effect of pLL extends to LPS as a PI3K activator, and results in diminished phosphorylation of GSK3 downstream from Akt. Functionally, the inhibition of Akt and GSK3 phosphorylation are linked to the blunted upregulation of CD40, a major feature of the unconventional maturation phenotype. Paradoxically, all aspects of unconventional maturation induced by pLL depend on PI3K class I. Additional components of the phagocytic machinery are needed, but phagocytosis of pLL particles is not required. These observations hint at a DC response mechanism related to receptor-independent mechanisms proposed for certain crystalline and synthetic polymer-based particles; this would fit the previously reported lack of detection of molecular-level motifs necessary of the effects of pLL on DCs. Finally, we report that DCs exposed to pLL are able to condition DCs not exposed to the material so that these cannot upregulate CD40 in full in response to LPS.</text>
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                <text>Infection and Immunity v. 87, no. 12, 2019. -- p. 1-19.--e00641-19</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Proliferation of macrophages is a hallmark of inflammation in many type 2 settings including helminth infections. The cellular expansion is driven by the type 2 cytokine interleukin-4 (IL-4), as well as by M-CSF, which also controls homeostatic levels of tissue resident macrophages. Cystic echinococcosis, caused by the tissue-dwelling larval stage of the cestode Echinococcus granulosus, is characterised by normally subdued local inflammation. Infiltrating host cells make contact only with the acellular protective coat of the parasite, called laminated layer, particles of which can be ingested by phagocytic cells. Here we report that a particulate preparation from this layer (pLL) strongly inhibits the proliferation of macrophages in response to IL-4 or M-CSF. In addition, pLL also inhibits IL-4-driven up-regulation of Relm-&amp;alpha;, without similarly affecting Chitinase-like 3 (Chil3/Ym1). IL-4-driven cell proliferation and up-regulation of Relm-&amp;alpha; are both known to depend on the phosphatidylinositol (PI3K)/Akt pathway, which is dispensable for induction of Chil3/Ym1. Exposure to pLL in vitro inhibited Akt activation in response to proliferative stimuli, providing a potential mechanism for its activities. Our results suggest that the E. granulosus laminated layer exerts some of its anti-inflammatory properties through inhibition of PI3K/Akt activation and consequent limitation of macrophage proliferation.</text>
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                <text>Application of passive modified atmosphere packaging (MAP) for shelf life extension of enzymatically and nonenzymatically peeled orange segments was evaluated. Oranges (Citrus sinensis cv. Valencia) were washed, sanitized and peeled by applying vacuum pulses only (vacuum peeling) and vacuum pulses followed by incubation in enzymatic solution (enzymatic peeling). Segments were packaged in polypropylene film and stored at 7C for 16 days. Package atmosphere composition, weight loss, respiration rate, color, instrumental texture, pH, soluble solids, sensory attributes, and bacterial and fungal growth were evaluated during storage. Microbiological limits (cfu/g&amp;thinsp;&amp;gt;&amp;thinsp;106) were reached by enzymatically and vacuum-peeled segments on days 12 and 8, respectively. Integrity and characteristic odor had significantly changed by this day. Vacuum-peeled segments presented better texture attributes and integrity (50% higher scores in sensory evaluation). Both types of segments benefited from MAP and are an attractive alternative for commercialization of ready-to-eat oranges. Practical Applications The information presented in this paper can assist fresh-cut producers in developing ready-to-eat oranges. Quality of segments obtained with two peeling methods was evaluated, and potentials and limitations of the segments obtained by each process were pointed out. Passive MAP in polypropylene at a reasonable storage temperature (7C) resulted to be an inexpensive technology that can extend segment shelf life in eventual cold storage of orange segments.</text>
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                <text>&lt;strong&gt;Patones moleculares asociados a pat&amp;oacute;genos (PAMPs) como base para nuevas inmunoterapias contra Streptococcus pneumoniae&lt;/strong&gt;</text>
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                <text>Streptococcus pneumoniae (neumococo) continua siendo el principal agente etiol&amp;oacute;gico de la neumon&amp;iacute;a adquirida en la comunidad en el mundo entero. Las defensas innatas son esenciales para la detecci&amp;oacute;n del neumococo y el control de la infecci&amp;oacute;n, en especial en etapas tempranas de la neumon&amp;iacute;a. Sin embargo, la bacteria ha desarrollado mecanismos de evasi&amp;oacute;n que le permiten escapar de la inmunidad natural, resultando muchas veces en la progresi&amp;oacute;n de la enfermedad. La creciente aparici&amp;oacute;n de cepas resistentes a antibi&amp;oacute;ticos, sumado al alto costo de los tratamientos y estrategias de profilaxis hace imperativo el desarrollo de nuevos tratamientos que puedan complementar los ya disponibles. Este trabajo se ha enfocado en el desarrollo de nuevas estrategias de tratamiento contra la neumon&amp;iacute;a neumoc&amp;oacute;cica basadas en el uso de inmunoestimulantes del sistema innato, administrados por ruta mucosa. Partiendo de la hip&amp;oacute;tesis de que la activaci&amp;oacute;n de las defensas innatas es suficiente para impedir la progresi&amp;oacute;n de la enfermedad, se evalu&amp;oacute; la capacidad de diferentes agonistas de receptores innatos de conferir protecci&amp;oacute;n frente a la neumon&amp;iacute;a invasiva en ratones, empleando cepas cl&amp;iacute;nicas de S. pneumoniae. Se demostr&amp;oacute; que la protecci&amp;oacute;n puede ser conferida tanto empleando agonistas de receptores activados normalmente por neumococo, como empleando agonistas de receptores que no son activados por neumococo durante una infecci&amp;oacute;n natural. Sin embargo, no todos los receptores activan respuestas protectoras y la estimulaci&amp;oacute;n por ciertas v&amp;iacute;as puede llegar incluso a tener consecuencias negativas. Flagelina de Salmonella enterica serovar Typhimurium, ligando de TLR5/NLRC4-NAIP5, fue uno de los agonistas estudiados. Flagelina confiri&amp;oacute; mayor protecci&amp;oacute;n que cualquiera de los otros agonistas probados, al ser administrado por ruta intranasal por lo que se realiz&amp;oacute; la caracterizaci&amp;oacute;n de los mecanismos moleculares y celulares asociados a su capacidad de inducir protecci&amp;oacute;n contra la neumon&amp;iacute;a neumoc&amp;oacute;cica. Los resultados sugieren que el efecto protector requiere del reclutamiento de neutr&amp;oacute;filos hacia los espacios alveolares, lo que se logra a trav&amp;eacute;s de la secreci&amp;oacute;n de citoquinas de la familia ELR-CXC por parte de las c&amp;eacute;lulas epiteliales de la mucosa respiratoria y es independiente de c&amp;eacute;lulas B, T y anticuerpos. La protecci&amp;oacute;n mostr&amp;oacute; ser dependiente de la presencia del motivo de uni&amp;oacute;n a TLR5 en la mol&amp;eacute;cula pero no de la regi&amp;oacute;n de interacci&amp;oacute;n con NLRC4-NAIP5, sugiriendo que los efectos observados dependen del reconocimiento extracelular de flagelina a trav&amp;eacute;s de TLR5 pero no del inflamasoma. La terapia demostr&amp;oacute; ser eficaz contra dos serotipos diferentes de neumococo. En segunda instancia, se realiz&amp;oacute; la puesta a punto de un modelo de inmunoterapia sublingual y se evalu&amp;oacute; la capacidad de flagelina de conferir protecci&amp;oacute;n frente al desaf&amp;iacute;o intranasal con neumococo administrada por esta ruta, obteni&amp;eacute;ndose un buen grado de protecci&amp;oacute;n. Al igual que en el modelo de instilaci&amp;oacute;n intranasal, la protecci&amp;oacute;n inducida por administraci&amp;oacute;n sublingual de flagelina, requiri&amp;oacute; reclutamiento de neutr&amp;oacute;filos y de la activaci&amp;oacute;n de la v&amp;iacute;a TLR5, pero no de la activaci&amp;oacute;n de inflamasoma v&amp;iacute;a NLRC4-NAIP5. 6 Como &amp;uacute;ltimo tema se estudi&amp;oacute; la capacidad adyuvante de flagelina en vacunas de aplicaci&amp;oacute;n sublingual. Empleando ovoalb&amp;uacute;mina como ant&amp;iacute;geno modelo se comprob&amp;oacute; que la administraci&amp;oacute;n de flagelina en conjunto con el ant&amp;iacute;geno incrementa la respuesta de anticuerpos espec&amp;iacute;ficos en suero, observ&amp;aacute;ndose un perfil de subclases mixto con predominio del perfil Th2. Empleando un modelo de transferencia adoptiva de c&amp;eacute;lulas T transg&amp;eacute;nicas para el receptor T y condicionada para reconocer el fragmento 323-339 de la ovoalb&amp;uacute;mina en contexto MHC-II, se estudi&amp;oacute; la capacidad de flagelina de inducir su proliferaci&amp;oacute;n en respuesta a una &amp;uacute;nica inmunizaci&amp;oacute;n sublingual y se determin&amp;oacute; la localizaci&amp;oacute;n anat&amp;oacute;mica de la respuesta. Se estudi&amp;oacute; adem&amp;aacute;s la contribuci&amp;oacute;n de los receptores TLR5 y NLRC4-NAIP5 confirm&amp;aacute;ndose que la se&amp;ntilde;alizaci&amp;oacute;n a trav&amp;eacute;s de uno solo es suficiente para el efecto adyuvante observado. Por &amp;uacute;ltimo, se analiz&amp;oacute; la capacidad de flagelina de promover procesamiento antig&amp;eacute;nico y expresi&amp;oacute;n de mol&amp;eacute;culas estimuladoras en c&amp;eacute;lulas dendr&amp;iacute;ticas derivadas de m&amp;eacute;dula &amp;oacute;sea. En suma, este trabajo destaca las ventajas de la potenciaci&amp;oacute;n de la inmunidad innata en mucosas mediante el empleo de Patrones Moleculares Asociados a Pat&amp;oacute;genos (PAMPs) para el desarrollo de nuevas estrategias de tratamiento y profilaxis de las infecciones respiratorias, y en particular las causadas por S. pneumoniae.</text>
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                <text>&lt;p&gt;&lt;em&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; &lt;/em&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;em&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&lt;/em&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>While it is known that toxic metals contribute individually to child cognitive and behavioral deficits, we still know little about the effects of exposure to multiple metals, particularly when exposures are low. We studied the association between children&amp;rsquo;s blood lead and hair arsenic, cadmium, and manganese and their performance on the Bayley Scales of Infant Development III. Ninety-two preschool children (age 13&amp;ndash;42 months) from Montevideo, Uruguay, provided a hair sample and 78 had a blood lead level (BLL) measurement. Using latent class analysis (LCA), we identified four groups of exposure based on metal concentrations: (1) low metals, (2) low-to-moderate metals, (3) high lead and cadmium, and (4) high metals. Using the four-group exposure variable as the main predictor, and fitting raw scores on the cognitive, receptive vocabulary, and expressive vocabulary scales as dependent variables, both complete-case and multiple imputation (MI) analyses were conducted. We found no association between multiple-metal exposures and neurodevelopment in covariate-adjusted models. This study demonstrates the use of LCA together with MI to determine patterns of exposure to multiple toxic metals and relate these to child neurodevelopment. However, because the overall study population was small, other studies with larger sample sizes are needed to investigate these associations.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
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                <text>One of the most important steps of new product development process is product optimization, which aims at identifying consumers&amp;rsquo; ideal products and directions for product reformulation. The present work proposes the application of a penalty analysis based on consumer responses to CATA questions to identify drivers of liking and directions for product reformulation. Two studies were conducted in which 74 and 119 consumers evaluated a set of samples (5 apples and 8 yogurts) using a check-all-that-apply question related to sensory characteristics and were also asked to check all the terms they considered appropriate to describe their ideal product. Data were analyzed by counting the number of consumers who did not check an attribute as they did for their ideal product, and its associated mean drop. A dummy variable transformation approach was proposed to make linear regression models between CATA terms and overall liking scores using Partial Least Squares (PLS). Juiciness, sweetness, apple flavor, firmness and crispiness were the most relevant attributes for consumers in the apple study. Meanwhile, in the yogurt study smoothness, homogeneity and creaminess were the main drivers of liking and were responsible for the highest penalization on overall liking (more than 1 in the 9-point hedonic scale). PLS regression enabled the identification of the attributes which deviation from the ideal caused a significant decrease in overall liking. Penalty analysis on CATA questions proved to be a simple and useful approach to identify drivers of liking and directions for improving the products in both studies. Advantages and disadvantages of this approach are discussed, as well as directions for further research</text>
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                <text>The development of new radiopharmaceuticals for the detection of hidden infection foci has great relevance for early detection and the selection of the correct treatment, particularly in immunosuppressed patients. In that sense, the labelling of antimicrobial peptides (AMPs) that are capable of binding specifically to the pathogenic microorganism which causes the infection, should provide a sufficiently specific agent, able to distinguish an infection from a sterile inflammation. Defensins are particularly interesting molecules with antimicrobial activity, the EcgDf1 defensin was identified from the genome of a Uruguayan native plant, Erythrina crista-galli, the &amp;lsquo;Ceibo&amp;rsquo; tree. Our group has previously reported a synthetic biologically active short analogue EcgDf21 (ERFTGGHCRGFRRRCFCTKHC) successfully labelled with 99mTc. Herein we present a shorter analogue which also preserves the &amp;gamma;-core domain, as a pharmacophore for a potential infection detection agent. This peptide was derivatized with the bifunctional chelating agent 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) through a lysine linker in the amino-terminal group (NOTA-KGHCRGFRRRC) and radiolabelled with 68Ga ([68Ga]Ga-NOTA-K-EcgDf1(10)). The [68Ga]Ga-NOTA-K-EcgDf1(10) labelling procedure rendered a product with high radiochemical purity and stability in the labelling milieu. The Log P value indicated that the complex has a hydrophilic behaviour, confirmed by the biodistribution profile. The [68Ga]Ga-NOTA-K-EcgDf1(10) complex demonstrated specific binding to cultures of Candida albicans and Aspergillus niger. Its biodistribution showed renal elimination and low accumulation in the rest of the body. It was possible to successfully differentiate sterile inflammation from infection by PET images in nude mice with a target/non-target ratio of 3.3 for C. albicans and 3.7 for A. niger, respectively.</text>
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                <text>&lt;a href="https://export.cvuy.uy/cv/?c3b26e04b115c427dde5cc8f9acc5f7e" target="_blank"&gt;&lt;strong&gt;Castro Rosas, Roberto&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a href="https://export.cvuy.uy/cv/?44fdd0a91803ce0502eee9f4ffadef292fcbecefdc292eac0c76afbdce088c91cd8be39ea544d8e9e9dbafc0d21627b25fe4e21ceccb4fe0015cc1e361df511f" target="_blank"&gt;&lt;strong&gt;Giglio, Javier&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a href="https://export.cvuy.uy/cv/?218b84c2789c9c69e07f34fe382a7957b23bce652811fe0d610d4cc4548f3798c0f8890d9ff98c7f5c1ba06ec276f43552fc8d108a551f3d4572b9632eebecb0" target="_blank"&gt;&lt;strong&gt;Cecchetto, Gianna&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Chemical Biology and Drug Design, v. 104, n&amp;ordm; 1, 2024. -- e14578</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>11 p.</text>
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