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                <text>Freshwater harmful algal blooms produce a broad array of bioactive compounds, with variable polarity. Acute exposure to cyanotoxins can impact the liver, nervous system, gastrointestinal tract, skin, and immune function. Increasing evidence suggests chronic effects from low-level exposures of cyanotoxins and other associated bioactive metabolites of cyanobacterial origin. These sundry compounds persist in drinking and recreational waters and challenge resource managers in detection and removal. A systematic approach to assess the developmental toxicity of cyanobacterial metabolite standards was employed utilizing a robust and high throughput developmental Danio rerio embryo platform that incorporated a neurobehavioral endpoint, photomotor response. Subsequently, we applied the platform to cyanobacterial bloom surface water samples taken from temperate recreational beaches and tropical lake subsistence drinking water sources as a model approach. Dechorionated Danio rerio embryos were statically immersed beginning at four to six hours post fertilization at environmentally relevant concentrations, and then assessed at 24 h and 5 days for morbidity, morphological changes, and photomotor response. At least one assessed endpoint deviated significantly for exposed embryos for 22 out of 25 metabolites examined. Notably, the alkaloid lyngbyatoxin&amp;ndash;a resulted in profound, dose-dependent morbidity and mortality beginning at 5 &amp;mu;g/L. In addition, hydrophobic components of extracts from beach monitoring resulted in potent morbidity and mortality despite only trace cyanotoxins detected. The hydrophilic extracts with several order of magnitude higher concentrations of microcystins resulted in no morbidity or mortality. Developmental photomotor response was consistently altered in environmental bloom samples, independent of the presence or concentration of toxins detected in extracts. While limited with respect to more polar compounds, this novel screening approach complements specific fingerprinting of acutely toxic metabolites with robust assessment of developmental toxicity, critical for chronic exposure scenarios.</text>
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                <text>&lt;strong&gt;Roegner, Amber&lt;/strong&gt;</text>
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                <text>Science of the Total Environment v. 697, 2019. -- p. 1-13.--e134210</text>
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                <text>NiLaZr and NiCuLaZr mixed metal oxide catalysts were prepared by co-precipitation with oxalic acid in alcoholic medium, followed by calcination. XRD analysis of the unreduced catalysts showed the formation of crystalline phases corresponding to the pyrochlore structure La2Zr2O7 and NiO following calcination at 850 ◦C, 900 ◦C and 950 ◦C. TEM microscopy of the amorphous solids obtained by calcination at 700 ◦C showed the formation of nanoparticles 20&amp;ndash;30 nm in size. TPR analysis showed a shift in the Ni and Cu reduction temperature towards lower values with increasing calcination temperature. All catalysts were active in runs of ethanol steam reforming, leading to the formation of gaseous mixtures containing hydrogen, carbon monoxide, carbon dioxide and methane. Deactivation due to carbon formation was observed at the lowest reaction temperature tested (500 ◦C). XRD, FTIR and thermogravimetric analysis revealed differences in the textural properties of catalysts before and after reforming, which varied in degree according to the catalyst calcination temperature. The NiCuLaZr catalysts showed a lower activity than their NiLaZr analogues, a fact that was ascribed to the formation of a nickel&amp;ndash;copper solution, with a lower catalytic activity in the cleavage of C C bonds.</text>
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                <text>Catalysis Today v. 213, 2013. -- p. 42-49</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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                <text>The objectives of this study were: to assess the efficiency of high hydrostatic pressure or ultra-high pressure homogenization against Mycobacterium smegmatis in milk and to discuss whether M. smegmatis can be considered a suitable surrogate for other Mycobacterium spp. in high pressure inactivation trials using milk. Three strains of this specie (CECT 3017, 3020 and 3032) were independently inoculated into both skimmed (0.2% fat) and whole milk (3.4% fat) at an approximate load of 6.5 Log CFU/ml and submitted to HHP treatments at 300, 400 or 500 MPa for 10 m at 6&amp;deg;C and 20&amp;deg;C. Evolution of the surviving cells of the inoculated strains was evaluated analysing milk immediately after the treatments and after 5 and 8 d of storage at 6&amp;deg;C. HHP treatments at 300 MPa were seldom efficient at inactivating M. smegmatis strains, but lethality increased with pressure applied in all cases. Generation of sub-lethal injured cells was observed only after 400 MPa treatments since inactivation at 500 MPa was shown to be complete. Significant differences were not observed due to either temperature of treatment or fat content of milk, except for strain CECT3032, which was shown to be the most sensitive to HHP treatments. Milk inoculated with strain CECT3017 was submitted to ultra-high pressure homogenization (UHPH) treatments at 200, 300 and 400 MPa. Maximum reductions were obtained after 300 and 400 MPa treatments, although less than 3.50 Log CFU/ml were inactivated. UHPH did not cause significant number of injured cells. The usefulness of this species as a marker for pressure-based processing seems limited since it showed greater sensitivity than some pathogenic species including other Mycobacteria reported in previous studies.</text>
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                <text>&lt;strong&gt;Risk of hedonic bias in sensory co-elicitations: Comparison of CATA questions and applicability ratings&lt;/strong&gt;</text>
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                <text>Co-elicitation of hedonic responses and sensory responses is now common. Against&lt;br /&gt;this background, this research compared the risk of hedonic bias from sensory checkall-that-apply (CATA) questions and sensory term ratings from unstructured line scales (RQ1) and evaluated if the risk of hedonic bias is independent of the sensory&lt;br /&gt;terms of the CATA question (RQ2). Seven studies with 137&amp;ndash;293 participants each were conducted, using different product categories. Between-subjects experimental designs were used and allocated consumers to one experimental condition (EC). For RQ1, these were hedonic, hedonic immediately followed by a CATA question, and&lt;br /&gt;hedonic immediately followed by a rating of term applicability (&amp;ldquo;not at all&amp;rdquo; to &amp;ldquo;extremely&amp;rdquo;). In RQ2, both ECs involved hedonic ratings followed by a CATA question, but the sensory terms differed. Results showed a significant effect of EC on&lt;br /&gt;hedonic ratings in three of five studies for RQ1, suggesting that hedonic bias may or may not occur. For RQ2, the terms of the CATA question influenced hedonic ratings in two of three studies, and a negative hedonic effect was seen when CATA terms drew attention to particular characteristics of individual samples. Collectively, the results suggest that likelihood of bias depends on interactions between product category, samples, and terms.&lt;br /&gt;Practical applications&lt;br /&gt;Results from the present work suggest that hedonic bias in sensory co-elicitations&lt;br /&gt;using CATA questions and scales may occur depending on the type of sensory attributes&lt;br /&gt;considered in the study. The consideration of terms that trigger attention to specific sensory attributes of the samples may lead to changes in hedonic ratings.&lt;br /&gt;Rating scales appear more likely to be associated with hedonic bias compared to CATA questions due to their more analytic approach to sample evaluation.&#13;
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                <text>The preparation, crystal structures, and magnetic properties of two novel mononuclear ReIV complexes of formula cis-[ReIVCl4(dmf)2] (1) and cis-[ReIVCl4(dma)2] (2) (dmf = N,N-dimethylformamide and dma = N,N-dimethylacetamide) have been studied. Both ReIV systems were synthesized through ligand substitution reactions from the cis-[ReIVCl4(MeCN)2] precursor, upon heating in the employed solvent. 1 and 2 crystallize in the monoclinic crystal system with space group C2/c. Each ReIV ion exhibits a distorted octahedral environment, being bonded by two oxygen atoms from two dmf (1) and dma (2) molecules and four chloride ions. In the crystal lattice of 1 and 2, the mononuclear ReIV complexes are placed generating short intermolecular ReIV-Cl⋯Cl-ReIV contacts. The magnetic properties of 1 and 2 were investigated through variable-temperature magnetic susceptibility measurements, which reveal significant antiferromagnetic exchange interactions between neighboring ReIV ions. In 1, these interactions account for a maximum in the magnetic susceptibility curve at ca. 5.0 K.</text>
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                <text>Two iron(II)-rhenium(IV) compounds of general formula [FeII(dmf)6][ReIVX6] [X = Cl (1) and Br (2); dmf = N,N-dimethylformamide] have been prepared and characterized. X-ray powder diffraction measurements on samples of 1 and 2 support the same structure for both systems. The crystal structure of 1 was determined by single-crystal X-ray diffraction. 1 crystallizes in the triclinic system with space group Pī. Each iron(II) is six-coordinate and bonded to six oxygens from six dmf molecules building a distorted octahedral environment. Rhenium(IV) is six-coordinate by six halide anions in an almost regular octahedral geometry. The magnetic properties were investigated from variable-temperature magnetic susceptibility measurements performed on microcrystalline samples of 1 and 2, whose experimental data were reproduced by a model of two isolated paramagnetic centers [S = 2 (FeII) and S = 3/2 (ReIV)] with large values of zero-field splitting (zfs) parameter. Keywords: Rhenium(IV) complexes, iron(II) complexes, X-ray diffraction, magnetic properties Sample our Engineering &amp;amp; Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days Journal of Information Display Sign up today for updates in your subject People also read Article Iron(II) complex of 2-(1H-pyrazol-1-yl)pyridine-4-carboxylic acid (ppCOOH) suitable for surface deposition V&amp;iacute;ctor Garc&amp;iacute;a-L&amp;oacute;pez et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 5 Feb 2018 Article Synthesis, X-ray crystal structure and DFT studies of cobalt(II) and vanadium(V) complexes with N,N,O-tridentate aroyl-hydrazone based ligand Mir Abolfazl Naziri et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 1 Published online: 15 Feb 2018 Article Syntheses, crystal structures and antibacterial activities of two new Mn(II) complexes based on triaryltriazoles Shi-Pei Zhang et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 1 Published online: 31 Jan 2018 Article Syntheses and crystal structures of organoindium(III) 1-D coordination polymers with bis(diphenylphosphino)alkane dioxides Clovis Peppe et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 22 Feb 2018 Article Copper(II)-dipicolinate-mediated clickable azide&amp;ndash;alkyne cycloaddition in water as solvent Lahoucine Bahsis et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 5 Published online: 20 Feb 2018 Article Synthesis, characterization and magnetic properties of mixed-valence iron complexes with 2-pyridyl oximes Lorena Mart&amp;iacute;nez et al.</text>
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                <text>&lt;strong&gt;Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans&lt;/strong&gt;</text>
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                <text>Selenoprotein T (SELENOT) is an endoplasmatic reticulum (ER)-associated redoxin that contains the amino acid selenocysteine (Sec, U) within a CXXU motif within a thioredoxin-like fold. Its precise function in multicellular organisms is not completely understood although it has been shown in mammals to be involved in Ca2+ homeostasis, antioxidant and neuroendocrine functions. Here, we use the model organism C. elegans to address SELENOT function in a whole organism throughout its life cycle. C. elegans possess two genes encoding SELENOT protein orthologues (SELT-1.1 and SELT-1.2), which lack Sec and contain the CXXC redox motif instead. Our results show that a Sec&amp;rarr;Cys replacement and a gene duplication were two major evolutionary events that occurred in the nematode lineage. We find that worm SELT-1.1 localizes to the ER and is expressed in different cell types, including the nervous system. In contrast, SELT-1.2 exclusively localizes in the cytoplasm of the AWB neurons. We find that selt-1.1 and selt-1.2 single mutants as well as the double mutant are viable, but the selt-1.1 mutant is compromised under rotenone-induced oxidative stress. We demonstrate that selt-1.1, but not selt-1.2, is required for avoidance to the bacterial pathogens Serratia marcescens and Pseudomonas aeruginosa. Aversion to the noxious signal 2-nonanone is also significantly impaired in selt-1.1, but not in selt-1.2 mutant animals. Our results suggest that selt-1.1 would be a redox transducer required for nociception and optimal organismal fitness. The results highlight C. elegans as a valuable model organism to study SELENOT-dependent processes.</text>
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                <text>Free Radical Biology and Medicine v. 108, 2017. -- p. 174-182</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Inhibition of tapeworm thioredoxin and glutathione pathways by an oxadiazole N-oxide leads to reduced Mesocestoides vogae infection burden in mice&lt;/strong&gt;</text>
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                <text>Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in flatworm parasites and a promising pharmacological target. We purified to homogeneity and characterized the TGR from the tapeworm Mesocestoides vogae (syn. M. corti). This purification revealed absence of conventional TR and GR. The glutathione reductase activity of the purified TGR exhibits a hysteretic behavior typical of flatworm TGRs. Consistently, M. vogae genome analysis revealed the presence of a selenocysteine-containing TGR and absence of conventional TR and GR. M. vogae thioredoxin and glutathione reductase activities were inhibited by 3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole N2-oxide (VL16E), an oxadiazole N-oxide previously identified as an inhibitor of fluke and tapeworm TGRs. Finally, we show that mice experimentally infected with M. vogae tetrathyridia and treated with either praziquantel, the reference drug for flatworm infections, or VL16E exhibited a 28% reduction of intraperitoneal larvae numbers compared to vehicle treated mice. Our results show that oxadiazole N-oxide is a promising chemotype in vivo and highlights the convenience of M. vogae as a model for rapid assessment of tapeworm infections in vivo.</text>
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                <text>&lt;strong&gt;Romanelli Cedrez, Laura&lt;/strong&gt;</text>
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                <text>Molecules v. 20, no. 7, 2015. -- p. 11793-11807</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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            <description>A name given to the resource</description>
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              <elementText elementTextId="568859">
                <text>&lt;strong&gt;HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium&lt;/strong&gt;</text>
              </elementText>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="568860">
                <text>SELENIO</text>
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              <elementText elementTextId="568861">
                <text>SELENITO</text>
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              <elementText elementTextId="568862">
                <text>SULFURO</text>
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              <elementText elementTextId="568863">
                <text>CAENORHABDITIS ELEGANS ORGANISMAL</text>
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              <elementText elementTextId="568864">
                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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              <elementText elementTextId="568865">
                <text>2020</text>
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          <element elementId="87">
            <name>Abstract</name>
            <description>A summary of the resource.</description>
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              <elementText elementTextId="568866">
                <text>Selenium is a trace element for most organisms; its deficiency and excess are detrimental. Selenium beneficial effects are mainly due to the role of the 21st genetically encoded amino acid selenocysteine (Sec). Selenium also exerts Sec-independent beneficial effects. Its harmful effects are thought to be mainly due to non-specific incorporation in protein synthesis. Yet the selenium response in animals is poorly understood. In Caenorhabditis elegans, Sec is genetically incorporated into a single selenoprotein. Similar to mammals, a 20-fold excess of the optimal selenium requirement is harmful. Sodium selenite (Na2SeO3) excess causes development retardation, impaired growth, and neurodegeneration of motor neurons. To study the organismal response to selenium we performed a genetic screen for C. elegans mutants that are resistant to selenite. We isolated non-sense and missense egl-9/EGLN mutants that confer robust resistance to selenium. In contrast, hif-1/HIF null mutant was highly sensitive to selenium, establishing a role for this transcription factor in the selenium response. We showed that EGL-9 regulates HIF-1 activity through VHL-1, and identified CYSL-1 as a key sensor that transduces the selenium signal. Finally, we showed that the key enzymes involved in sulfide and sulfite stress (sulfide quinone oxidoreductase and sulfite oxidase) are not required for selenium resistance. In contrast, knockout strains in the persulfide dioxygenase ETHE-1 and the sulfurtransferase MPST-7 affect the organismal response to selenium. In sum, our results identified a transcriptional pathway as well as enzymes possibly involved in the organismal selenium response.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="568867">
                <text>&lt;strong&gt;Romanelli-Credrez, Laura&lt;/strong&gt;</text>
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              <elementText elementTextId="568868">
                <text>&lt;strong&gt;Doitsidou, Mar&amp;iacute;a&lt;/strong&gt;</text>
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              <elementText elementTextId="568869">
                <text>&lt;strong&gt;Alkema, Mark J.&lt;/strong&gt;</text>
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              <elementText elementTextId="568870">
                <text>&lt;strong&gt;Salinas, Gustavo&lt;/strong&gt;</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="568871">
                <text>Frontiers in Genetics v. 11, 2020. -- p. 1-11.--e63</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="568872">
                <text>Frontiers</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="568873">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="568874">
                <text>&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor sobre toda creaci&amp;oacute;n&lt;/strong&gt; literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="568875">
                <text>PDF</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="568876">
                <text>Ingl&amp;eacute;s</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="568877">
                <text>Art&amp;iacute;culo</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="568878">
                <text>DOI: 10.3389/fgene.2020.00063</text>
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        <name>Caenorhabditis elegans orgarganismal</name>
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        <name>Selenio</name>
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        <name>Selenito</name>
      </tag>
      <tag tagId="989">
        <name>Sulfuro</name>
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