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                <text>Nitro-fatty acids(NO2-FA)areelectrophilicsignalingmediatorsformedintissuesduringinflammation, which areabletoinducepleiotropiccytoprotectiveandantioxidantpathwaysincludingupregulationof Nuclearfactorerythroid2-relatedfactor2(Nrf2)responsivegenes.AmyotrophicLateralSclerosis(ALS)is a fatalneurodegenerativediseasecharacterizedbythelossofmotorneuronsassociatedtoanin- flammatoryprocessthatusuallyaggravatesthediseaseprogression.InALSanimalmodels,theactivation of thetranscriptionfactorNrf2inastrocytesconfersprotectiontoneighboringneurons.Itiscurrently unknown whetherNO2-FAcanexertprotectiveactivityinALSthroughNrf2activation.Hereinwede- monstratethatnitro-arachidonicacid(NO2-AA) ornitro-oleicacid(NO2-OA)administratedtoastrocytes expressingtheALS-linkedhSOD1G93A induce antioxidantphaseIIenzymeexpressionthroughNrf2ac- tivationconcomitantwithincreasingintracellularglutathionelevels.Furthermore,treatmentof hSOD1G93A-expressingastrocyteswithNO2-FApreventedtheirtoxicitytomotorneurons.Transfectionof siRNAtargetedtoNrf2mRNAsupportedtheinvolvementofNrf2activationinNO2-FA-mediatedpro- tectiveeffects.Ourresultsshowforthe first timethatNO2-FAinduceapotentNrf2-dependentanti- oxidantresponseinastrocytescapableofpreventingmotorneuronsdeathinaculturemodelofALS</text>
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&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
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                <text>Fifteen new allyldithiocarbimates were prepared from different allylic bromides and various potassium dithiocarbimates, yielding (Z)-2-(methoxycarbonyl)-3-(X-nitrophenyl)allyl-(N-R-sulfonyl)dithiocarbimates (where X = 2, 3 and 4; R = phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl and 4-iodophenyl). These anions were isolated as tetraphenylphosphonium salts and characterized by HRMS, infrared, 1H and 13C NMR spectroscopies. Molecular electrostatic potentials were used to evaluate intermolecular interactions present in the new substances and to explain variations observed on their melting points. Single crystal X-ray diffraction experiments confirmed the Z stereochemistry of the allyldithiocarbimate anions. C&amp;ndash;HO, C&amp;ndash;HN, C&amp;ndash;HS and C&amp;ndash;H&amp;pi; intermolecular interactions in the solid state were studied by X-ray diffraction and Hirshfeld surface analyses. The new compounds inhibited the mycelial growth of various fungi species responsible for severe plant diseases. The allylithiocarbimates were especially active against Botrytis cinerea, with IC50 values as low as 20 &amp;mu;M, being more effective than the active principals of the commercial fungicides Ziram and Mancozeb.</text>
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                <text>Biodiesel generated by transesterification of triglycerides from renewable sources is a clean form of energy that is currently used in many countries in blends with petrodiesel. It is mainly produced from food-grade vegetable oils obtained from oleaginous crops. High prices of these oils have made the sustainability of biodiesel production questionable. The use of nonedible feedstocks, such as intracellular triglycerides accumulated by oleaginous yeasts, appears as a feasible alternative. However, it has been demonstrated that an economically sustainable production of yeast oil could only be possible if lowcost media based on industrial subproducts, or wastes are used. In this work, we propose intracellular lipids production by a previously selected oleaginous yeast strain in a medium composed only by sugar cane vinasse and crude glycerol. Different culture strategies were studied. The highest biomass and lipid yields were obtained when the yeast R. graminis S1/2R was cultivated in batch without control of dissolved oxygen. The fatty acid methyl esters obtained under these conditions met the specification of international biodiesel standards.</text>
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&lt;p dir="ltr"&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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                <text>The effects of partial replacement of chromium by molybdenum was studied on the structure and electrochemical kinetic properties of ZrCr1-xNiMox(x = 0.0, 0.3 and 0.6) metal hydride alloys. The arc-melting prepared alloys were metallurgically characterized by X-ray diffraction and energy dispersive spectroscopy microanalysis, which showed AB2 (with hexagonal C14 structure) and ZrxNiy (Zr7Ni10, Zr9Ni11) phases. After a partial substitution of chromium by molybdenum, secondary phases monotonically increase with the C14 unit cell volume indicating that most of molybdenum atoms locate in the B-site.&lt;br /&gt;&lt;br /&gt;The alloys were electrochemically characterized using charge/discharge cycling, electrochemical impedance spectroscopy and rate capability experiments that allowed the determination of hydriding reaction kinetic parameters. The presence of molybdenum produces a positive effect for hydrogen diffusion in the alloy lattice, and ZrCr0.7NiMo0.3 alloy depicts the better kinetics associated with a fast activation, lower charge transfer resistance and the best high rate discharge behavior. This fact would be related to a lower diffusion time constant and a bigger value of the product between exchange density current and surface active area. There is a trade-off in the amounts of secondary phase and Laves phases in order to improve the kinetic performance.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>&lt;strong&gt;Teliz, Erika&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Estudio estructural de compuestos de transferencia de carga del 1,3,5- trinitrobenceno con compuestos org&amp;aacute;nico poliarom&amp;aacute;ticos&lt;/strong&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>&lt;strong&gt; The perinatal presence of antigen (p-azophenylarsonate) or anti-u antibodies lead to the loss of the recurrent idiotype (CRIA) in A/J mice.&lt;/strong&gt;</text>
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                <text>The immune response of A/J mice against p-azophenylarsonate (Ars)&amp;mdash;keyhole limpet hemocyanln(KLH) is characterized by the dominance, late in primary and during the secondary, of a recurrent Idiotype called CRIA, encoded by a canonical combination of Ig gene segments. In this study, A/J mice were given Ars coupled to deaggregated human gamma globulins (dHGG) within 24 h after delivery. The offsprings from these mice were then exposed as adults to Ars&amp;mdash;KLH. These animals developed an unusual immune response. The level of anti-Ars antibodies was nearly normal but a dramatic shift In repertoire was observed: the cross-reactive idiotype which is the hallmark of the anti-Ars response in A/J mice was completely absent. The idiotype could be recovered by injection of anti-idiotypic antibodies alone, with no need of llpopolysaccharlde coupling. Therefore the presence of antigen at birth can lead to a strong perturbation of idiotype selection. Similar results were obtained with neonatal treatment using antl-IgM antibodies. After recovery of suppression, A/J mice can mount an anti-arsonate response of normal level but devoid of the dominant idiotype.</text>
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                <text>&lt;strong&gt;Ryelandt, M&lt;/strong&gt;</text>
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                <text>International Immunology v. 4, 1994. -- p. 645-652</text>
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                <text>The Japanese Society for Immunology</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The mechanism and the final outcome of the Knoevenagel-Doebner reaction are discussed. The condensation reaction between different hydroxy-substituted aromatic aldehydes and malonic acid is performed using piperidine as organocatalyst. The key role of the catalyst is clearly pointed out during the decarboxylation of ferulic acid, without the use of a strong decarboxylating agent, leading to a 4-vinylphenol derivative. Based on the results obtained, the studied pathway may be important in the understanding of vinylphenol produc-tion during malting and brewing of wheat and barley grains. Finally, changing the solvent of the reaction from pyridine to water in the Knoevenagel-Doebner reaction of 4-hydroxybenzaldehydes, dimerization of resulting styrene derivatives is observed. These results can be of interest also in the field of food chemistry, since cinnamic acids are frequently found in fruits and vegetables used for human consumption</text>
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                <text>Open Journal of Physical Chemistry v. 1, 2011. -- p. 85-93</text>
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&lt;p style="margin-bottom: 0cm;" align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Theoretical study of sequence selectivity and preferred binding mode of psoralen with DNA&lt;/strong&gt;</text>
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                <text>Psoralen interaction with two models of DNA was investigated using molecular mechanics and molecular dynamics methods. Calculated energies of minor groove binding and intercalation were compared in order to define a preferred binding mode for the ligand.We found that both binding modes are possible, explaining the low efficiency for monoadduct formation from intercalated ligands. A comparison between the interaction energy for intercalation between different base pairs suggests that the observed sequence selectivity is due to favorable intercalation in 5�-TpA in (AT)n sequences.</text>
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                <text>Research Letters in Physical Chemistry no. 60623, 2007. --</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI:10.1155/2007/60623</text>
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                <text>&lt;p&gt;Las proteasas son enzimas notables que participan en innumerables procesos fisiol&amp;oacute;gicos importantes en los animales. Sin embargo, la prote&amp;oacute;lisis no regulada puede llevar a la aparici&amp;oacute;n de algunas enfermedades funcionales. Los inhibidores de proteasas desempe&amp;ntilde;an funciones cruciales en el desarrollo y la supervivencia de los par&amp;aacute;sitos. Estos inhibidores participan en la modulaci&amp;oacute;n de las respuestas inmunes de sus hu&amp;eacute;spedes vertebrados. Los miembros de la familia de las serpinas (inhibidores de serino-proteasas por sus siglas en ingl&amp;eacute;s) son inhibidores irreversibles de las serino-proteasas y regulan los sistemas relacionados con la defensa contra los par&amp;aacute;sitos. Actualmente hay informaci&amp;oacute;n limitada disponible sobre los inhibidores de la proteasa del trematodo hemat&amp;oacute;fago Fasciola hepatica. En esta tesis, se caracterizaron cuatro serpinas de F. hepatica (FhS-1 - FhS-4). La caracterizaci&amp;oacute;n bioqu&amp;iacute;mica revel&amp;oacute; que rFhS-2 inhibe la actividad de la catepsina G de neutr&amp;oacute;filos humanos. Comparativamente, rFhS-4 inhibe la actividad de la quimotripsina pancre&amp;aacute;tica bovina y la catepsina G. En consecuencia, el &amp;iacute;ndice de estequiometr&amp;iacute;a (SI) para rFhS-2 y catepsina G fue 2.6, mientras que para rFhS-4 fue 2.4 para quimotripsina y 1.3 para catepsina G. Adem&amp;aacute;s, se observ&amp;oacute; la formaci&amp;oacute;n de complejos irreversibles entre rFhS-2 y rFhS-4 con estas proteasas. El an&amp;aacute;lisis bioqu&amp;iacute;mico de rFhS-4 demuestra que tiene una constante de segundo orden (ka) de 3.8 x 103 M-1 s-1 para quimotripsina. De manera similar, con otras serpinas, ambas prote&amp;iacute;nas recombinantes se unen a la heparina con alta afinidad. La localizaci&amp;oacute;n en tejidos demostr&amp;oacute; que estas serpinas no est&amp;aacute;n localizadas en los mismos &amp;oacute;rganos, que FhS-2 se localiza en el ovario y FhS-4 en las c&amp;eacute;lulas intestinales, y ambos se ubicaron conjuntamente en las espinas dentro del tegumento. Estos hallazgos proporcionan la base para los posibles roles funcionales de estas prote&amp;iacute;nas como parte de un mecanismo del gusano adulto para evadir el sistema inmunitario del hu&amp;eacute;sped y proteger los huevos para continuar el ciclo de vida del par&amp;aacute;sito. Una mayor comprensi&amp;oacute;n del papel funcional de estas serpinas podr&amp;iacute;a conducir al descubrimiento de nuevas intervenciones de control antiparasitario.&lt;/p&gt;</text>
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&lt;p dir="ltr"&gt;&lt;span&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/span&gt;&lt;/p&gt;&#13;
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          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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                <text>&lt;strong&gt;Hyperthyroidism keeps immunoglobulin levels but reduces milk fat and CD11b/c+ cells on early lactation&lt;/strong&gt;</text>
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                <text>TIROXINA</text>
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                <text>LECHE HUMANA</text>
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                <text>LACTANCIA MATERNA</text>
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                <text>LEUCOCITOS</text>
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                <text>ANTICUERPOS</text>
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                <text>HIPERTIROIDISMO</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>2024</text>
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                <text>Thyroid hormones influence mammary gland differentiation and lactation by binding to thyroid hormone receptors. Hyperthyroidism disrupts pregnancy and lactation, affecting offspring growth and milk production. Despite maternal milk is a vital source of bioactive compounds and nutrients for newborns, it is unclear whether hyperthyroidism alters its composition, mainly immune factors. Therefore, our work aimed to evaluate the influence of hyperthyroidism on milk quality and immunological parameters during early lactation. Twelve-weekold female Wistar rats received daily injections of 0,25 mg/kg T4 (HyperT, n = 20) or vehicle (control, n = 19) starting 8 days before mating and continuing throughout pregnancy. Rats were euthanized on day 2 of lactation for analyzing the impact of hyperthyroidism on mammary gland, serum and milk samples. HyperT pups exhibited reduced weight, length and head circumference with altered serum hormones, glucose and albumin levels. HyperT mammary gland analysis revealed structural changes, including decreased alveolar area, adipose tissue, increased connective tissue and reduced epithelial elongation, accompanied by decreased TR&amp;beta;1 RNA expression. HyperT milk displayed lower caloric value and fat concentration. HyperT animals exhibited altered milk immune cell counts, displaying increased numbers of CD45+ and CD3+ cells and decreased CD11b/c+ cells without changes on milk and serum IgA, IgG and IgG2a levels. In summary, we have demonstrated that hyperthyroidism affects mammary gland morphology, disrupts pup development and alters biochemical and immunological parameters. Our findings highlight the impact of maternal hyperthyroidism on offspring early development and milk immune composition, underscoring the importance of thyroid function in maternal and neonatal immune health.</text>
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                <text>&lt;strong&gt;S&amp;aacute;nchez, Mar&amp;iacute;a Bel&amp;eacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Michel Lara, Mar&amp;iacute;a Cecilia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Neira, Flavia Judith&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rodr&amp;iacute;guez-Camejo, Claudio&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;R&amp;iacute;os, Juan Manuel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Viruel, Luciana Bel&amp;eacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Moreno-Sosa, Mar&amp;iacute;a Tamara&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Pietrobon, Elisa Olivia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Soaje, Marta&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Jahn, Graciela Alma&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Hern&amp;aacute;ndez, Ana&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Valdez, Susana Ruth&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mackern-Oberti, Juan Pablo&lt;/strong&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="704822">
                <text>&lt;span data-sheets-formula-bar-text-style="font-size:13px;color:#000000;font-weight:normal;text-decoration:none;font-family:'Arial';font-style:normal;text-decoration-skip-ink:none;"&gt;Molecular and Cellular Endocrinology, v. 594, 2024. -- e112370&lt;/span&gt;</text>
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              <elementText elementTextId="704823">
                <text>Elsevier</text>
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              <elementText elementTextId="704824">
                <text>2024</text>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="704825">
                <text>&lt;div class="element-text"&gt;&#13;
&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;/div&gt;</text>
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                <text>13 p.</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="704828">
                <text>Ingl&amp;eacute;s</text>
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                <text>Art&amp;iacute;culo</text>
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            <name>Identifier</name>
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      <tag tagId="190">
        <name>Anticuerpos</name>
      </tag>
      <tag tagId="7665">
        <name>Hipertiroidismo</name>
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      <tag tagId="7501">
        <name>Lactancia materna</name>
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      <tag tagId="6885">
        <name>Leche Humana</name>
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        <name>Leucocitos</name>
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        <name>Tiroxina</name>
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                    <text>131</text>
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                  <text>Bibliografía Nacional Química</text>
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              <description>An account of the resource</description>
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                <elementText elementTextId="709198">
                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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              <name>Contributor</name>
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              <elementTextContainer>
                <elementText elementTextId="709199">
                  <text>Departamento de Documentación y Biblioteca</text>
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                  <text>RIQUIM</text>
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          <name>Original Format</name>
          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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            <elementText elementTextId="252807">
              <text>PDF</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>&lt;strong&gt;Tissue transglutaminase on trophoblast cells as a possible target of autoantibodies contributing to pregnancy complications in celiac patients&lt;/strong&gt;</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="252786">
                <text>ENZIMAS</text>
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                <text>ENFERMEDAD CELIACA</text>
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                <text>EMBARAZO-COMPLICACIONES</text>
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                <text>TRANSGLUTAMINASAS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>2014</text>
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          <element elementId="87">
            <name>Abstract</name>
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                <text>&lt;div id="aji12290-sec-0001" class="section"&gt;&#13;
&lt;h4&gt;Problem&lt;/h4&gt;&#13;
&lt;div class="para"&gt;&#13;
&lt;p&gt;Women with celiac disease (CD) are often affected by atypical presentations of the disease associated with reproductive disorders as a main extra-digestive complaint. Here, we analyzed if autoantibodies against tissue transglutaminase (tTG) in sera from CD patients with reproductive disorders could display direct effects through their interaction with tTG expressed on trophoblast cells and phagocytes inducing tissue damage and interfering in the clearance of trophoblast apoptotic bodies.&lt;/p&gt;&#13;
&lt;/div&gt;&#13;
&lt;/div&gt;&#13;
&lt;div id="aji12290-sec-0002" class="section"&gt;&#13;
&lt;h4&gt;Method of study&lt;/h4&gt;&#13;
&lt;div class="para"&gt;&#13;
&lt;p&gt;Sera from CD women with reproductive disorders were obtained, and their ability to induce apoptosis of Swan-71 (cytotrophoblast cell line) and to modulate the wound-healing and phagocytes process was tested.&lt;/p&gt;&#13;
&lt;/div&gt;&#13;
&lt;/div&gt;&#13;
&lt;div id="aji12290-sec-0003" class="section"&gt;&#13;
&lt;h4&gt;Results&lt;/h4&gt;&#13;
&lt;div class="para"&gt;&#13;
&lt;p&gt;Swan-71 cells expressed tTG and CD sera displayed a significant decrease in trophoblast cell migration and a delay in injury healing on trophoblast cells, compared with those observed with control sera. Moreover, CD sera significantly reduced trophoblast cell proliferation and increased apoptosis levels in comparison with those observed in the control sera. Finally, autoantibodies against tTG interfere in the clearance of trophoblast apoptotic bodies through a mechanism involving MFG-E8 (milk fat globulin-EGF factor 8)&amp;ndash;tTG binding.&lt;/p&gt;&#13;
&lt;/div&gt;&#13;
&lt;/div&gt;&#13;
&lt;div id="aji12290-sec-0004" class="section"&gt;&#13;
&lt;h4&gt;Conclusion&lt;/h4&gt;&#13;
&lt;div class="para"&gt;&#13;
&lt;p&gt;The anti-tTG antibodies might contribute to trophoblast damage and disrupt the phagocytosis process of apoptotic bodies that could promote a pro-inflammatory microenvironment.&lt;/p&gt;&#13;
&lt;/div&gt;&#13;
&lt;/div&gt;</text>
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                <text>&lt;strong&gt;S&amp;oacute;&amp;ntilde;ora Muniz, Cecilia Beatriz&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Calo, Guillermina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fraccaroli, Laura&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;P&amp;eacute;rez-Leir&amp;oacute;s, Claudia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Hern&amp;aacute;ndez, Ana&lt;/strong&gt;</text>
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              <elementText elementTextId="252798">
                <text>&lt;strong&gt;Ramhorst, Rosanna&lt;/strong&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="252799">
                <text>American Journal of Reproductive Immunology v. 72, no. 5, 2014. -- p. 485-495</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="252800">
                <text>Wiley-Blackwell</text>
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            <name>Date</name>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="252802">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;span&gt;Traumatic brain injury (TBI) remains as one of the leading causes of mortality and morbidity worldwide and there are no effective treatments currently available. Gene therapy applications have emerged as important alternatives for the treatment of diverse nervous system injuries. New strategies are evolving with the notion that each particular pathological condition may require a specific vector. Moreover, the lack of detailed comparative studies between different vectors under similar conditions hampers the selection of an ideal vector for a given pathological condition. The potential use of lentiviral vectors versus several modular protein-based nanovectors was compared using a controlled cortical impact model of TBI under the same gene therapy conditions. We show that variables such as protein/DNA ratio, incubation volume, and presence of serum or chloroquine in the transfection medium impact on both nanovector formation and transfection efficiency&amp;nbsp;&lt;/span&gt;&lt;em&gt;in vitro&lt;/em&gt;&lt;span&gt;. While lentiviral vectors showed&amp;nbsp;&lt;/span&gt;&lt;em&gt;GFP&lt;/em&gt;&lt;span&gt;&amp;nbsp;protein 1 day after TBI and increased expression at 14 days, nanovectors showed stable and lower&amp;nbsp;&lt;/span&gt;&lt;em&gt;GFP&lt;/em&gt;&lt;span&gt;&amp;nbsp;transgene expression from 1 to 14 days. No toxicity after TBI by any of the vectors was observed as determined by resulting levels of IL-1&amp;beta; or using neurological sticky tape test. In fact, both vector types induced functional improvement&amp;nbsp;&lt;/span&gt;&lt;em&gt;per se&lt;/em&gt;&lt;span&gt;.&lt;/span&gt;</text>
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                <text>&lt;strong&gt;Negro Demontel, Mar&amp;iacute;a Luciana&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ferrer Miralles, Neus&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Vazquez, Esther&lt;/strong&gt;</text>
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                <text>&lt;span&gt;Molecular Therapy-Methods and Clinical Development&amp;nbsp;v. 1, 2014. -- 11p.-- e14047&lt;/span&gt;</text>
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                <text>The American Society of Gene &amp;amp; Cell Therapy</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;El efecto de la molienda sobre el hidr&amp;oacute;xido de magnesio precipitado : parte II. estudio roentgenogr&amp;aacute;fico&lt;/strong&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Papel</text>
              </elementText>
              <elementText elementTextId="396270">
                <text>PDF</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="396271">
                <text>Espa&amp;ntilde;ol</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
            <elementTextContainer>
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                <text>Art&amp;iacute;culo</text>
              </elementText>
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        </elementContainer>
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    </elementSetContainer>
    <tagContainer>
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        <name>Fisicoquímica</name>
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      <tag tagId="2896">
        <name>Hidróxido de magnesio</name>
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      <tag tagId="1047">
        <name>Magnesio</name>
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</itemContainer>
