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                  <text>Bibliografía Nacional Química</text>
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                <text>&lt;strong&gt;Active methylotrophs in the sediments of Lonar Lake, a saline and alkaline ecosystem formed by meteor impact&lt;/strong&gt;</text>
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                <text>Lonar Lake is a unique saline and alkaline ecosystem formed by meteor impact in the Deccan basalts in India around 52,000 years ago. To investigate the role of methylotrophy in the cycling of carbon in this unusual environment, stable-isotope probing (SIP) was carried out using the one-carbon compounds methane, methanol and methylamine. Denaturing gradient gel electrophoresis fingerprinting analyses performed with heavy (13)C-labelled DNA retrieved from sediment microcosms confirmed the enrichment and labelling of active methylotrophic communities. Clone libraries were constructed using PCR primers targeting 16S rRNA genes and functional genes. Methylomicrobium, Methylophaga and Bacillus spp. were identified as the predominant active methylotrophs in methane, methanol and methylamine SIP microcosms, respectively. Absence of mauA gene amplification in the methylamine SIP heavy fraction also indicated that methylamine metabolism in Lonar Lake sediments may not be mediated by the methylamine dehydrogenase enzyme pathway. Many gene sequences retrieved in this study were not affiliated with extant methanotrophs or methylotrophs. These sequences may represent hitherto uncharacterized novel methylotrophs or heterotrophic organisms that may have been cross-feeding on methylotrophic metabolites or biomass. This study represents an essential first step towards understanding the relevance of methylotrophy in the soda lake sediments of an unusual impact crater structure</text>
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                <text>&lt;strong&gt;Antony, C. P.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Kumaresan, D.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Shouche, Y. S.&lt;/strong&gt;</text>
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                <text>ISME Journal v. 4, no. 11, 2010. -- p. 1470-1480</text>
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                <text>International Society for Microbial Ecology</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>ISSN: 1751-7362</text>
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                <text>&lt;strong&gt;Derivatizations of Sgc8-c aptamer to prepare metallic radiopharmaceuticals as imaging diagnostic agents : Syntheses, isolations, and physicochemical characterizations&lt;/strong&gt;</text>
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                <text>Aptamers, oligonucleotides with the capability to bind to a target through non-covalent bonds with high affinity and specificity, have a great number of advantages as scaffold to prepare molecular imaging agents. In this sense, we have performed post-SELEX modifications of a truncated aptamer, Sgc8-c, which bind to protein tyrosine kinase 7 to obtain a specific molecular targeting probe for in vivo diagnosis and in vivo therapy. Herein, we describe the synthetic efforts to prepare conjugates between Sgc8-c and different metallic ions chelator moieties in short times, high purities, and adequate yields. The selected chelator moieties, derived from 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-benzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid, and 6-hydrazinonicotinic acid, were covalently attached at the 5'-aptamer position yielding the expected products which were stable in aqueous solution up to 75&amp;deg;C and in typical aptamer storage conditions at least for 30 days.</text>
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                <text>&lt;strong&gt;Sicco, Estefan&amp;iacute;a.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ibarra, Manuel.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Cerecetto, Hugo.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Calzada, Victoria&lt;/strong&gt;</text>
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                <text>Chemical Biology and Drug Design v.91, no. 3, 2018. -- p. 747-755</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1111/cbdd.13135</text>
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                <text>&lt;strong&gt;Sgc8-c Aptamer as a Potential Theranostic Agent for Hemato-Oncological Malignancies&lt;/strong&gt;</text>
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                <text>Background: Aptamers represent an emerging class of oligonucleotides that have the ability to bind ligands with high affinity. Sgc8-c aptamer recognizes PTK7, a member of the catalytically defective receptor protein tyrosine kinase family that is upregulated in various cancers, including hemato-oncological malignancies. Herein, an Sgc8-c-NOTA-radiolabeled probe was prepared for theranostic purpose. Materials and Methods: In this work, an Sgc8-c-radiolabeled probe against PTK7 was prepared, and biological evaluations&amp;mdash;pharmacokinetic studies, biodistribution analysis, and in vivo molecular imaging&amp;mdash;were performed. To obtain the radiolabeled probe, a modified 5&amp;prime;-amino-derivative of the Sgc8-c aptamer was bound to the metal chelator NOTA, and subsequently labeled with 67Ga with high yield and radiochemical purity. The precursor, Sgc8-c-NOTA, the radio probe Sgc8-c-NOTA-67Ga, and its nonradioactive complex, Sgc8-c-NOTA-69/71Ga, were purified by reverse-phase high-performance liquid chromatography and characterized by electrospray ionization mass spectrometry. The binding ability of Sgc8-c-NOTA-67Ga was studied in vitro against purified PTK7 receptor. In addition, the binding was also evidenced against the hemato-oncological A20 cell line, derived from B lymphocytes, and the corresponding A20-green fluorescent protein (GFP)-transfected cells. The proof of concept was performed on A20-GFP tumor-bearing mice, in which the biodistribution of the radiolabeled probe was evaluated through imaging, using X-ray, fluorescence, and &amp;gamma; modalities. The specific uptake of the probe was confirmed by blocking with the Sgc8-c aptamer in an in vivo competition assay. Results: The biodistribution results showed considerable uptake in tumor since 2&amp;thinsp;h, with highest at 48&amp;thinsp;h postinjection. However, the blood and muscle ID/g (injected dose per gram of tissue) activities were decreasing with time and tumor/no-target ratios increasing to 20 at 24&amp;thinsp;h postinjection. These results are consistent with the in vivo images. Conclusions: This study supports the utility of Sgc8-c-NOTA radiolabeled as a theranostic agent.</text>
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                <text>&lt;strong&gt;Sicco, Estefan&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Baez, Jessica&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ibarra, Manuel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fern&amp;aacute;ndez, Marcelo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Cabral, Pablo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Cerecetto, Hugo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Calzada, Victoria&lt;/strong&gt;</text>
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                <text>Cancer Biotheraphy and Radiopharmaceuticals v. 35,no. 4, 2020. -- p. 262-270</text>
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                <text>&lt;span&gt;Mary Ann Liebert&lt;/span&gt;</text>
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1089/cbr.2019.3402</text>
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                <text>&lt;strong&gt;La variaci&amp;oacute;n de la energ&amp;iacute;a libre est&amp;aacute;ndar y la espontaneidad de las reacciones qu&amp;iacute;micas&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Sienra, Beatriz&lt;/strong&gt;</text>
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                <text>Anuario Latinoamericano de Educaci&amp;oacute;n Qu&amp;iacute;mica v.22, no. 24, 2008-2009. -- p. 119-123</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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            <name>Format</name>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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              <description>A name given to the resource</description>
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                  <text>Bibliografía Nacional Química</text>
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              <description>An account of the resource</description>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                  <text>Departamento de Documentación y Biblioteca</text>
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          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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                <text>&lt;strong&gt;Biogenic approaches using citrus extracts for the synthesis of metal nanoparticles :the role of flavonoids in gold reduction and stabilization&lt;/strong&gt;</text>
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            <name>Subject</name>
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                <text>FLAVONOIDES</text>
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                <text>CITRUS</text>
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                <text>NANOTECNOLOGIA</text>
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                <text>EXTRACTO DE CITRUS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>2016</text>
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                <text>Synthesis of nanoparticles free from toxic chemicals and solvents is highly seen for large-scale production processes, particularly for use in biomedical/biotechnological applications. So far, although several methods for synthesis of metal nanoparticles using citrus extracts have been described, none of them clarify which compounds are responsible for both reduction and stabilization of NPs. Here we report the role of citrus flavonoids, hesperidin, hesperetin, rutin, naringenin, quercetin and diosmin, in the synthesis of gold nanoparticles (AuNP) at room temperature. Only in the presence of the citrus flavonoids, diosmin (Dm), and hesperetin (Ht), the reduction of HAuCl4 in concentrations as high as 7 mM under alkaline conditions yielded concentrated and self-stabilized suspensions of uniform spherical nanoparticles with a narrow size distribution. We went further and focused on Ht, the most abundant flavonoid aglycone from citrus fruits known for its medicinal properties. HtAuNPs were characterized using high-resolution transmission electron microscopy, dynamic light scattering, X-ray photoelectron spectrometry and UV-Vis spectrophotometry. The NPs remained stable for months without significant changes in their shape and optical properties. Theoretical calculations using density functional theory were used to identify the functional groups involved in the electron transfer from the Ht molecules to gold, which seems to be the consequence of an initial complexation, leading to the reduction of Au3+ ions into Au0. Besides, this procedure provides a one-pot method, showing potential for large-scale.</text>
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            <name>Creator</name>
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                <text>&lt;strong&gt;Sierra, Jelver Alexander&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Vanoni, Caio Raphael&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Tumelero, Milton Andr&amp;eacute;&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Campos Pl&amp;aacute;, Cristiani&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=fc7cd71892b1a9968ee19230dafdbd01" target="_blank"&gt;&lt;strong&gt;Faccio, Ricardo&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Ferreira Franceschini, Dante&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Creczynski-Pasa, Tania Beatriz&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Pasa, Andr&amp;eacute; Avelino&lt;/strong&gt;</text>
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                <text>New Journal of Chemistry v. 40, 2016. -- p. 1420-1429</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
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                <text>RCS</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2016</text>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="381331">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguient&lt;/p&gt;</text>
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            <description>A language of the resource</description>
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                <text>Ingl&amp;eacute;s</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Art&amp;iacute;culo</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.1039/C5NJ02128F</text>
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        <name>Citrus</name>
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      <tag tagId="509">
        <name>Flavonoides</name>
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      <tag tagId="254">
        <name>Nanotecnología</name>
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            <description>The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.</description>
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                <name>Bit Depth</name>
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                    <text>8</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Tesis de doctorado, maestría, trabajos de diploma y monografías técnicas</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="709186">
                  <text>Versiones electrónicas de las tesis de doctorado, maestría y trabajos de diploma de la Facultad de Química, Universidad de la República (UdelaR).&#13;
Incluye únicamente trabajos hasta el año 2023. Los trabajos posteriores se encuentran disponibles en el Repositorio Colibrí.</text>
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              <name>Contributor</name>
              <description>An entity responsible for making contributions to the resource</description>
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                  <text>Departamento de Documentación y Biblioteca</text>
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                  <text>RIQUIM</text>
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      <description>A resource containing textual data.  Note that facsimiles or images of texts are still of the genre text.</description>
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          <name>Original Format</name>
          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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            <elementText elementTextId="527841">
              <text>Papel</text>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
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                <text>&lt;strong&gt;Biotransformaci&amp;oacute;n del Glicerol, obtenido en la producci&amp;ograve;n de biodi&amp;eacute;sel en productos de mayor valor agregado&lt;/strong&gt;</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>QUIMICA ORGANICA</text>
              </elementText>
              <elementText elementTextId="527825">
                <text>BIOCATALISIS</text>
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              <elementText elementTextId="527826">
                <text>BIOTRANSFORMACI&amp;Oacute;N</text>
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              <elementText elementTextId="527827">
                <text>GLICEROL</text>
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          <element elementId="87">
            <name>Abstract</name>
            <description>A summary of the resource.</description>
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              <elementText elementTextId="527828">
                <text>La producci&amp;oacute;n de biodi&amp;eacute;sel mediante la reacci&amp;oacute;n de transesterificaci&amp;oacute;n (&amp;uacute;nico proceso tecnol&amp;oacute;gicamente maduro a la fecha para ese prop&amp;oacute;sito) genera simult&amp;aacute;neamente como subproducto glicerol en relaci&amp;oacute;n aproximadamente 9:1 en masa. La evoluci&amp;oacute;n positiva que en los &amp;uacute;ltimos a&amp;ntilde;os ha presentado la producci&amp;oacute;n de este biocombustible a nivel global ha desencadenado la introducci&amp;oacute;n de vol&amp;uacute;menes inmanejables para el mercado del glicerol, presionando fuertemente a la baja su precio. Este hecho -de no encontrarse una soluci&amp;oacute;namenaza impactar en la sustentabilidad ambiental y econ&amp;oacute;mica del biodi&amp;eacute;sel. La b&amp;uacute;squeda de alternativas a esta sobreproducci&amp;oacute;n de glicerol ha sido un desaf&amp;iacute;o atendido por la comunidad cient&amp;iacute;fica internacional desarroll&amp;aacute;ndose m&amp;uacute;ltiples estrategias (desde la b&amp;uacute;squeda de nuevas aplicaciones que permitan su uso directo, el uso enproductos masivos que lo demanden como insumo, as&amp;iacute; como la b&amp;uacute;squeda de s&amp;iacute;ntesis de productos que impliquen agregado de valor a este co-producto). El presente trabajo se inscribe dentro de esta &amp;uacute;ltima alternativa proponiendo la valorizaci&amp;oacute;n del glicerol a trav&amp;eacute;s de su biotransformaci&amp;oacute;n en 1,2-propanodiol enantiom&amp;eacute;ricamente puro y su posterior derivatizaci&amp;oacute;n obteni&amp;eacute;ndose sintones quirales con aplicaci&amp;oacute;n en qu&amp;iacute;mica fina. Recurriendo a ingenier&amp;iacute;a metab&amp;oacute;lica en E. coli se handise&amp;ntilde;ado, construido y evaluado un conjunto de biocatalizadores con ese objetivo. A partir de la expresi&amp;oacute;n de la metilglioxal sintasa (mgs) de E. coli,una metilglioxal reductasa (Gre2p) y una aldeh&amp;iacute;do reductasa(Ypr1p ) ambas de S. cerevisiae,se ha logrado obtener (R)-1,2-propanodiol enantiom&amp;eacute;ricamente puro (con un e.e. &amp;gt; 99 %, en concentraci&amp;oacute;n de 0,45 g/L)a partir de glicerol. Esteproducto, adem&amp;aacute;s de constituir una alternativa de valorizaci&amp;oacute;n en s&amp;iacute; mismo es punto de partida para otros compuestos de elevado valor agregado,entre ellos, en el presente trabajo se ha logrado la s&amp;iacute;ntesis qu&amp;iacute;mica del (R)-2-metoxi metoxi-1-propanoly de (R)- propilencarbonato</text>
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                <text>&lt;strong&gt;Sierra, Wilson&lt;/strong&gt;</text>
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            <name>Publisher</name>
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                <text>Montevideo: UdelaR-Facultad de Qu&amp;iacute;mica</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2017</text>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8ca340da794ac0eade285d2d2721ec5d" target="_self"&gt;&lt;strong&gt;Gonz&amp;aacute;lez, Andr&amp;eacute;s&lt;/strong&gt; &lt;/a&gt;(director de Tesis)</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=a581298e2ecd56b3a39da57d3bac3b3a" target="_self"&gt;&lt;strong&gt;Rodriguez, Sonia&lt;/strong&gt;&lt;/a&gt;&lt;a&gt;&lt;/a&gt; (directora de Tesis)</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=c63a421d8a96930bcc9fb16ef3819110" target="_self"&gt;&lt;strong&gt;Men&amp;eacute;ndez, Pilar&lt;/strong&gt;&lt;/a&gt; (directora de Tesis)</text>
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            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="527835">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Espa&amp;ntilde;ol</text>
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            <description>The nature or genre of the resource</description>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Los m&amp;eacute;todos primarios constituyen el nivel jer&amp;aacute;rquico de medici&amp;oacute;n m&amp;aacute;s elevado debido a que permiten implementar la trazabilidad a las unidades del Sistema Internacional. El objetivo de este trabajo fue la optimizaci&amp;oacute;n de un m&amp;eacute;todo primario para la determinaci&amp;oacute;n de creatinina en suero humano por diluci&amp;oacute;n isot&amp;oacute;pica mediante cromatograf&amp;iacute;a gaseosa acoplada a espectrometr&amp;iacute;a de masa (GC &amp;ndash; IDMS), adaptado de un m&amp;eacute;todo de referencia publicado en el Joint Committee for Traceability in Laboratory Medicine (JCTLM - BIPM). Se optimizaron factores vinculados a las etapas de equilibrado isot&amp;oacute;pico y derivatizaci&amp;oacute;n. Para esto se realiz&amp;oacute; un dise&amp;ntilde;o experimental de tres factores en dos niveles (dise&amp;ntilde;o 23) y un an&amp;aacute;lisis de varianza de un factor (ANOVA). Las respuestas evaluadas en el dise&amp;ntilde;o experimental fueron la se&amp;ntilde;al correspondiente a la creatinina, la eficiencia de derivatizaci&amp;oacute;n, la relaci&amp;oacute;n de eficiencia de derivatizaci&amp;oacute;n y el sesgo. El m&amp;eacute;todo propuesto, optimizado para las etapas de equilibrado isot&amp;oacute;pico y derivatizaci&amp;oacute;n, presenta mayor eficiencia y simplicidad comparado con el m&amp;eacute;todo original, y cuenta con un sesgo adecuado al prop&amp;oacute;sito. Luego de su validaci&amp;oacute;n podr&amp;aacute; ser implementado para el desarrollo de herramientas de aseguramiento de la calidad de los laboratorios cl&amp;iacute;nicos que realizan estas mediciones rutinariamente.</text>
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                <text>Innotec : Revista del Laboratorio Tecn&amp;oacute;logico del Uruguay no. 17, 2019. -- p. 102-116</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir&lt;strong&gt; l&lt;/strong&gt;os documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Development of new antimicrobial agents, capable of combating resistant and multidrug-resistant fungal and bacterial clinical strains, is necessary. This study presents the synthesis and antimicrobial screening of 42 2-substituted-1,4-benzenediols, being 10 novel compounds. In total, 23 compounds showed activity against fungi and/or bacteria. Benzenediol compounds 2, 5, 6, 8, 11, and 12 demonstrated broad spectrum antimicrobial actions, including resistant and multidrug-resistant species of dermatophytes (Trichophyton mentagrophytes), Candida spp. and the ESKAPE panel of bacteria. Minimum inhibitory concentrations of these compounds for fungi and bacterial strains ranged from 25 to 50 &amp;micro;g/ml and 8&amp;ndash;128 &amp;micro;g/ml, respectively. The antifungal mechanism of action is related to the fungal cell wall of dermatophytes and membrane disruption to dermatophytes and yeasts, in the presence of compound 8. Specific structural changes, such as widespread thinning along the hyphae and yeast lysis, were observed by scanning electron microscopy. The effects of compound 8 on cell viability are dose-dependent; however they did not cause genotoxicity and mutagenicity in human leukocyte cells nor haemolysis. Moreover, the compounds were identified as nonirritant by the ex-vivo Hen&amp;rsquo;s egg test-chorioallantoic membrane (HET-CAM). The furan-1,4-benzenediol compound 5 showed in vivo efficacy to combat S. aureus infection using embryonated chicken eggs. Therefore, the compounds 8, and 5 are promising as hits for the development of new antimicrobial drugs with reduced toxicity.</text>
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                <text>Saudi Pharmaceutical Journal v, 27, no. 8, 2019. -- p. 1064-1074</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona&lt;/p&gt;</text>
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                <text>An on-line preconcentration system for the simultaneous determination of Copper (Cu)&lt;br /&gt;and manganese (Mn) in water samples was developed and coupled to a microwave-induced plasma optical emission spectrometer (MIP OES). The flow injection system was designed with a minicolumn packed with sisal fiber (Agave sisalana). A multivariate experimental design was performed to evaluate the influence of pH, preconcentration time, and eluent concentration. Optimal conditions for sample preparation were pH 5.5, preconcentration time was 90 s, and HCl 0.5 mol L-1 was the eluent. The main figures of merit were detection limits 3.7 and 9.0 �g L-1 for Cu and Mn, respectively.&lt;br /&gt;Precision was expressed as a relative standard deviation better than 10%. Accuracy was evaluated&lt;br /&gt;via spiked recovery assays with recoveries between 75&amp;ndash;125%. The enrichment factor was 30 for&lt;br /&gt;both analytes. These results were adequate for water samples analysis for monitoring purposes.&lt;br /&gt;The preconcentration system was coupled and synchronized with the MIP OES nebulizer to allow&lt;br /&gt;simultaneous determination of Cu and Mn as a novel sample introduction strategy. The sampling rate was 20 samples/h. Sisal fiber resulted an economical biosorbent for trace element preconcentration without extra derivatization steps and with an awfully time of use without replacement complying with the principles of green analytical methods.&lt;br /&gt;&#13;
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&lt;p dir="ltr"&gt;&lt;span&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/span&gt;&lt;/p&gt;&#13;
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                <text>Biorsorbents can be used to pack minicolumns for the preconcentration of trace elements and thus improve the detection limits of some techniques. A biosorbent is efficient when presents binding sites as carbonyls, amines, and carboxylic groups, among others. Thus, natural materials as the sisal fiber (Agave sisalana) may be a good candidate. Sisal fiber demonstrated good performance for Cu preconcentration when it was impregnated with alizarine fluorine blue (AFB). However, very good results were reported for the first time by our group with this column, without the use of additional reagents for both, Mn and Cu determinations in water samples by using microwave plasma atomic emission spectroscopy (MP AES). In this paper a comparison of the sisal fiber preparation with and without impregnation with AFB is presented and discussed in terms of the figures of merit, including precision, trueness, limits of detection and quantification. In addition to that, the number of determinations without the need of replacement of the solid phase was evaluated. Results demonstrated that the impregnation of sisal fiber with AFB does not leads to an improvement in the analytical performance. Analytical Greenness Metric Approach (AGREE) was used to evaluate the greenness of both methods and results obtained were similar. Despite this, the method without impregnation of the fiber has some remarkable advantages, that contributes to Green Analytical Chemistry (GAC), related to the lifetime of the sorbent, not considered in the AGREE tool.</text>
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                <text>&lt;strong&gt;Silva, Javier&lt;/strong&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;A brief overview of Materials Science in Uruguay&lt;/strong&gt;</text>
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                <text>CIENCIA DE LOS MATERIALES</text>
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                <text>Materials science is a growing research area in Uruguay. In order to obtain a brief overview of the research done we collected information about research in this field. As a starting point, we searched in the Scopus database for the keywords: affiliation country: &amp;ldquo;Uruguay&amp;rdquo; and subject: &amp;ldquo;Materials Science&amp;rdquo; (using the &amp;ldquo;Timb&amp;oacute;&amp;rdquo; platform). We inspected the records and we analyzed them to construct a timeline. The data show that we are in a steady state regime of number of publications that we expect to increase together with the number of students in the area, with the generation of long term policies (grants, funding opportunities), and, if we get involved in a community that promotes this area of interest.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>EI &amp;oacute;xido nitrico ("NO) es un mensajero biol6gico sumamente importante y versatil, involucrado en la neurotransmisi6n, el mantenimiento de la homeostasis vascular y en los mecanismos primarios de la defensa inmune. Es un radical libre producido in vivo por un grupo de enzimas lIamada Oxido Nitrico Sintasas (NOS). Los efectos del &amp;middot;NO estan mediados por reacciones directas con hemoproteinas 0 mediante especies reactivas derivadas de reacciones del &amp;middot;NO con oxigeno, super6xido y metales. La nitrosaci6n de tioles proteicos es una modificaci6n dependiente de &amp;middot;NO que ha tomado un gran protagonismo ultimamente, ya que estarla implicada en mecanismos de serializaci6n celular. A pesar de haberse encontrado mas de 100 protefnas con cistefnas modificadas por S-nitrosaci6n, aun es necesario establecer cuales son los mecanismos par los que se forman y descomponen estos compuestos in vivo. Para esto es necesario contar con una tecnica de identificaci6n y caracterizaci6n de S-nitrosotioles (RSNO) eficiente. Se han desarrollado varios metod os para la cuantificaci6n y determinaci6n de RSNO de bajo peso molecular y proteicos, entre ellos encontramos el metodo de Saville, la quimioluminiscencia y el biotin switch. EI biotin switch es el metodo de referencia para la identificaci6n de proteinas S-nitrosadas, pero sufre de baja reproducibilidad en los resultados. Esta tecnica se basa en la reducci6n del RSNO con ascorbato, dejando los tioles libres para la uni6n con un reactivo biotinilado, marcando especificamente los tioles que se encontraban nitrosados. La eficiencia del ascorbato como agente reductor ha mostrado ser variable y dependiente de la muestra biol6gica a analizar, y se ha identificado como el punto debil de la tecnica de biotin switch. Por esta raz6n nos planteamos estudiar metodologias alternativas para la denitrosaci6n de RSNO. En este trabajo se ensay6 en primer lugar la capacidad de halogenuros, seudohalogenuros, y una variedad de organomercuriales, de denitrosar RSNO de bajo peso molecular (S-nitrosoglutati6n) y proteicos (S-nitrosoalbumina y S-nitrosotiorredoxina). Demostramos que el ioduro tiene una capacidad denitrosante significativa, destacandose dentro de los halogenuros ensayados. Por otro lado se via que los organomercuriales efectivamente reaccionan con RSNO, provocando la denitrosaci6n y uniendose a los tioles. En funci6n de los resultados obtenidos se evalua la utilidad de estos organomercuriales como potenciales herramientas para el desarrollo de una nueva tecnica de descomposici6n e identificaci6n especifica de S-nitrosotioles.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;em&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&lt;/em&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Echinoccocus granulosus is the causative agent of Cyst Echinococcosis, a zoonotic infection affecting humans and livestock representing a public health and an economic burden for several countries. Despite decades of investigation an effective vaccine still remains to be found. Parasitic cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins (CAPs) have been proposed as vaccine candidates against helmith's infection. In this work we have identified two novel proteins of this superfamily expressed at the protoescoleces larval stage named EgVAL1 and EgVAL2. The open reading frame sequences were deduced. The aminoacidic sequence was analyzed and confronted against already known vertebrate' and helminth's proteins sequences in order to infer putative functions. Immunolocalization studies were also performed. The obtained data supported by immunolocalization studies and homology models suggest that these proteins could be involved in protease activity inhibition.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep&lt;/strong&gt;</text>
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                <text>Vaccine v. 29, no. 48, 2011. -- p. 9057-9063</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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