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                <text>The quinazoline derivatives (3-chloro-4-fluorophenyl)quinazoline-4,6-diamine (2) and (3-bromophenyl)quinazoline-4,6-diamine (3) were labelled with 99mTc using the &amp;ldquo;4 + 1&amp;rdquo; mixed-ligand system [Tc(NS3)(CN-R)] and the tricarbonyl moiety fac-[Tc(CO)3]+. In the &amp;ldquo;4 + 1&amp;rdquo; approach the technetium(III) is stabilized by a monodentate isocyanide bearing a quinazoline fragment (L11, L22) and by the tetradentate tripodal ligand tris(2-mercaptoethyl)-amine (NS3). In the &amp;ldquo;4 + 1&amp;rdquo; approach, 99mTc-labelling was performed in a two-step procedure, the complexes [Tc(NS3)(L11)] (7a) and [Tc(NS3)(L22)] (8a) being obtained in about 50&amp;ndash;70% yield. In the tricarbonyl approach, the fac-[Tc(CO)3]+ unit is anchored by two different monoanionic chelators bearing the quinazoline derivatives (3-chloro-4-fluorophenyl)quinazoline-4,6-diamine (2) and (3-bromophenyl)quinazoline-4,6-diamine (3). Both chelators have a N2O donor atom set, but one contains a pyrazolyl ring (L55H) and the other contains a pyridine unit (L66H). In both cases the conjugation of the quinazoline to the chelator was done through the secondary amine of the potentially tridentate and monoanionic chelators, the corresponding 99mTc-complexes (10a, 11a) being obtained in quantitative yield. The identities of the 99mTc-labelled quinazolines (7a, 8a, 10a, 11a) were confirmed by comparison with the HPLC profiles of the analogous Re compounds (7, 8, 10, 11). All these Re complexes were characterized by NMR and IR spectroscopy, elemental analysis and in some cases by MS and X-ray diffraction analysis. In vitro studies indicate that the quinazoline fragments, after conjugation to the cyano group (L11, L22) or to the pyrazolyl containing chelator (L55H), as well as the corresponding Re complexes (7, 8, 10) inhibit significantly the EGFR autophosphorylation and also inhibit A431 cell growth. These two effects were also found for the pyridine-containing chelator (L66H) and corresponding Re complex (11), although to a lesser extent.</text>
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                <text>Dalton Transactions no. 24, 2008. -- p.3215-3225</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects about 10 million people in Latin America, the current chemotherapy is still inadequate. The discovery of new drugs is urgently needed. Our group is focused on the development of prospective metal-based drugs mainly based on bioactive ligands and pharmacologically interesting metal ions. In this work three new rhenium(I) tricarbonyl compounds fac-[ReI(CO)3Br(HL)] where HL = 5-nitrofuryl containing thiosemicarbazones were synthesized and fully characterized in solution and in the solid state. The in vitro evaluation of the compounds on T. cruzi trypomastigotes (Dm28c strain) showed that the Re(I) compounds are 8 to 15 times more active than the reference drug Nifurtimox and show a 4 to 17 fold increase in activity in respect to the free (HL) ligands. Obtained compounds also show good selectivity indexes (IC50 endothelial cells Ea.hy926/IC50 T. cruzi (Dm28c tripomastigotes)). 1H NMR and MS studies, performed with time, showed that the fac-[Re(CO)3Br(HL)] species convert into the dimers [Re2(CO)6(L)2] in solution. Crystal structure of [ReI2(CO)6(L2)2], the product of complexes' dimerization, was solved. Related to the mechanism of action, the studied compounds do not generate radical oxygen species in the parasite (as 5-nitrofuryl derived thiosemicarbazones do) probably due to the unfavorable nitro reduction potential of the generated dimeric species. On the contrary, the compounds produce a decrease of the oxygen consumption rate of the parasites, maybe inhibiting their mitochondrial respiration.</text>
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                <text>Journal of Inorganic Biochemistry v. 170, 2017. -- p. 125-133</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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            <element elementId="50">
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          <name>Original Format</name>
          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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          <element elementId="50">
            <name>Title</name>
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              <elementText elementTextId="410248">
                <text>&lt;strong&gt;Ricerche sui simpatolitici di sintese nella serie della ergotammina : VI. N. derivati delle Z-amminotetralina concatine ramificate contenenti funzioni amminiche ed ammichiche&lt;/strong&gt;</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>FARMACOLOGIA</text>
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              <elementText elementTextId="410250">
                <text>SIMPATOLITICOS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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              <elementText elementTextId="410253">
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                <text>&lt;strong&gt;Falco, M. R.&lt;/strong&gt;</text>
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                <text>&lt;p&gt;Rendiconti dell'Istituto Superiore di Sanità v. 15, 1952. -- p. 826&lt;/p&gt;</text>
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          <element elementId="45">
            <name>Publisher</name>
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              <elementText elementTextId="410256">
                <text>Istituto Superiore di Sanit&amp;agrave;</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>1952</text>
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            </elementTextContainer>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="410258">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="410259">
                <text>PDF</text>
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          <element elementId="44">
            <name>Language</name>
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            <elementTextContainer>
              <elementText elementTextId="410260">
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          <element elementId="51">
            <name>Type</name>
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              <elementText elementTextId="410261">
                <text>Art&amp;iacute;culo</text>
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      <tag tagId="573">
        <name>Farmacología</name>
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                <name>Bit Depth</name>
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            <element elementId="50">
              <name>Title</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>&lt;strong&gt;Riesgo de Infecci&amp;oacute;n Toxopl&amp;aacute;smica del Feto Humano en Montevideo&lt;/strong&gt;</text>
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                <text>TOXOPLASMOSIS HUMANA</text>
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                <text>FETO</text>
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              <elementText elementTextId="354360">
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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          <element elementId="87">
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                <text>Se determin&amp;oacute; la incidencia de la infecci&amp;oacute;n toxopl&amp;aacute;smica en 449 mujeres de 15 a 40 a&amp;ntilde;os en Montevideo con la reacci&amp;oacute;n de Sabin y Feldman. Se calcul&amp;oacute; que entre 2,5 y 4,2 de cada 1000 fetos se infectarian con T.gondii , sufriendo las consecuencias patol&amp;oacute;gicas conocidas. Se comparan los resultados con los obtenidos en otros pa&amp;iacute;ses. Se discuten los recursos para la prevenci&amp;oacute;n o atenuaci&amp;oacute;n del da&amp;ntilde;o fetal por Toxoplasma : la educaci&amp;oacute;n sanitaria de la embarazada y la determinaci&amp;oacute;n del IgM total en sangre del cord&amp;oacute;n, seguida de la b&amp;uacute;squeda de anticuerpos espec&amp;iacute;ficos para el grupo de infecciones prenatales (toxoplasmosis, citomegalovirus, rub&amp;eacute;ola, herpes, s&amp;iacute;filis). Se resalta la importancia de proseguir las investigaciones sobre una vacuna para aplicar a las mujeres seronegativas que deseen quedar embarazadas y de la vacunaci&amp;oacute;n de los gatos contra la eliminaci&amp;oacute;n de ooquistes ya factible.</text>
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                <text>&lt;strong&gt;Freyre, A.&lt;/strong&gt;</text>
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              <elementText elementTextId="354366">
                <text>&lt;strong&gt;Queiruga, G.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;M&amp;eacute;ndez, J.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Lavarello, L.&lt;/strong&gt;</text>
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            <elementTextContainer>
              <elementText elementTextId="354371">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread Latin American parasitic disease, novel complexes of the bioactive ligand risedronate (Ris, (1-hydroxy-1- phosphono-2-pyridin-3-yl-ethyl)phosphonate), [MII(Ris)2]&amp;middot;4H2O, where M Cu, Co, Mn and Ni, and [NiII(Ris)2 (H2O)2]&amp;middot;H2O were synthesized and characterized by using analytical measurements, thermogravimetric analyses, cyclic voltammetry and infrared and Raman spectroscopies. Crystal structures of [CuII(Ris)2]&amp;middot;4H2O and [NiII(Ris)2(H2O)2]&amp;middot;H2O were solved by single crystal X-ray diffraction methods. The complexes, as well as the free ligand, were evaluated in vitro against epimastigotes and intracellular amastigotes of the parasite Trypanosoma cruzi, causative agent of Chagas disease. Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against T. cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels. In addition, this strong activity could be related to high inhibition of farnesyl diphosphate synthase enzyme. On the other hand, protein interaction studies showed that all the complexes strongly interact with albumin thus providing a suitable means of transporting them to tissues in vivo.</text>
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                <text>&lt;strong&gt;Demoro, Bruno&lt;/strong&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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                <text>&lt;strong&gt;Risk of hedonic bias in sensory co-elicitations: Comparison of CATA questions and applicability ratings&lt;/strong&gt;</text>
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                <text>Co-elicitation of hedonic responses and sensory responses is now common. Against&lt;br /&gt;this background, this research compared the risk of hedonic bias from sensory checkall-that-apply (CATA) questions and sensory term ratings from unstructured line scales (RQ1) and evaluated if the risk of hedonic bias is independent of the sensory&lt;br /&gt;terms of the CATA question (RQ2). Seven studies with 137&amp;ndash;293 participants each were conducted, using different product categories. Between-subjects experimental designs were used and allocated consumers to one experimental condition (EC). For RQ1, these were hedonic, hedonic immediately followed by a CATA question, and&lt;br /&gt;hedonic immediately followed by a rating of term applicability (&amp;ldquo;not at all&amp;rdquo; to &amp;ldquo;extremely&amp;rdquo;). In RQ2, both ECs involved hedonic ratings followed by a CATA question, but the sensory terms differed. Results showed a significant effect of EC on&lt;br /&gt;hedonic ratings in three of five studies for RQ1, suggesting that hedonic bias may or may not occur. For RQ2, the terms of the CATA question influenced hedonic ratings in two of three studies, and a negative hedonic effect was seen when CATA terms drew attention to particular characteristics of individual samples. Collectively, the results suggest that likelihood of bias depends on interactions between product category, samples, and terms.&lt;br /&gt;Practical applications&lt;br /&gt;Results from the present work suggest that hedonic bias in sensory co-elicitations&lt;br /&gt;using CATA questions and scales may occur depending on the type of sensory attributes&lt;br /&gt;considered in the study. The consideration of terms that trigger attention to specific sensory attributes of the samples may lead to changes in hedonic ratings.&lt;br /&gt;Rating scales appear more likely to be associated with hedonic bias compared to CATA questions due to their more analytic approach to sample evaluation.&#13;
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