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                <text>Small compounds cannot bind simultaneously to two antibodies, and thus, their immunodetection is limited to competitive formats in which the analyte is indirectly quantitated by measuring the unoccupied antibody binding sites using a competing reporter. This limitation can be circumvented by using phage-borne peptides selected for their ability to specifically react with the analyte&amp;ndash;antibody immunocomplex, which allows the detection of these small molecules in a noncompetitive format (PHAIA) with increased sensitivity and a positive readout. In an effort to find substitutes for the phage particles in PHAIA, we explore the use of the B subunit of the Shiga-like toxin of Escherichia coli, also known as verotoxin (VTX), as a scaffold for multivalent display of anti-immunocomplex peptides. Using the herbicides molinate and clomazone as model compounds, we built peptide&amp;ndash;VTX recombinant chimeras that were produced in the periplasmic space of E. coli as soluble pentamers, as confirmed by multiangle light scattering analysis. These multivalent constructs, which we termed nanopeptamers, were conjugated to a tracer enzyme and used to detect the herbicide&amp;ndash;antibody complex in an ELISA format. The VTX&amp;ndash;nanopeptamer assays performed with over a 10-fold increased sensitivity and excellent recovery from spiked surface and mineral water samples. The carbon black-labeled peptide&amp;ndash;VTX nanopeptamers showed great potential for the development of a lateral-flow test for small molecules with a visual positive readout that allowed the detection of up to 2.5 ng/mL of clomazone.</text>
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                <text>&lt;strong&gt;Lassabe Harguindeguy, Gabriel&lt;/strong&gt;</text>
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                <text>Analytical Chemistry v. 86, no.11, 2014. -- p. 5541-5546</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Short- and long-range structure correlations with ionic transport near the glass transition for lithium-ion polyacrylonitrile-based electrolytes using DMSO plasticizer&amp;nbsp;&lt;/strong&gt;</text>
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                <text>&lt;p&gt;Here, we report a joint experimental and theoretical study using molecular dynamics calculations focusing on short- and long-range structure correlations with ionic transport near the glass transition for lithium-ion polyacrylonitrile-&lt;br /&gt;based electrolytes using DMSO as plasticizer. The presence of subtle modifications of the polymeric structural features near the glass transition (Tg) is rarely reported in the literature and could be relevant to study free volume in polymer-based electrolytes. Our in-situ small angle X-ray scattering (SAXS) analysis at different temperatures evidence an increment of free volume and partial loss of long-range coherence between polyacrylonitrile neighbor chains just above Tg in strong correlation with an Arrhenius behavior crossover observed&lt;br /&gt;for the ionic transport in these polyacrylonitrile-based electrolytes. Advancing the understanding of lithium-ion&lt;br /&gt;conductivity Arrhenius behavior for polymeric electrolytes with Tg slightly above room temperature could be of great relevance due to the overlap with the operating temperature range of lithium-ion batteries.&lt;/p&gt;</text>
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                <text>Journal of Non-Crystalline Solids,&amp;nbsp;v. 561, 2021. -- e120744</text>
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&lt;p dir="ltr"&gt;&lt;span&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/span&gt;&lt;/p&gt;&#13;
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                <text>Emotion word questionnaires remain dominant in food-related emotion research despite acknowledged limitations. Emoji questionnaires can overcome some of these limitations but are not yet regarded as a strong alternative to emotion word questionnaires. We believe they have the potential to earn this right and use this invited opinion piece to explain why. Following a brief introduction about emoji, advantages of emoji questionnaires are summarised: &amp;ndash; enhanced ecological validity, familiarity and cross-culturally shared meanings. We then address concerns that hinder uptake of emoji questionnaires, including emoji meanings/interpretations, appropriateness for older consumers and ability to represent emotional arousal (activation to deactivation). Finally, we offer suggestions for how to accelerate the uptake of emoji questionnaires in sensory and consumer science, which include: i) more applied studies using emoji questionnaires, ii) establishing emoji meanings in the context of eating of drinking, iii) adopting open-ended question formats, iv) comparing emoji and emotion word questionnaires, and v) establishing guidelines for emoji questionnaires. An important spill-over benefit of research to develop emoji questionnaires is that it exposes the lack of similar research for emotion word questionnaires. We encourage colleagues in the field to engage in the task of conducting needed methodological research on emoji and emotion words alike.&#13;
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                <text>Emotion word questionnaires remain dominant in food-related emotion research despite acknowledged limitations. Emoji questionnaires can overcome some of these limitations but are not yet regarded as a strong alternative to emotion word questionnaires. We believe they have the potential to earn this right and use this invited opinion piece to explain why. Following a brief introduction about emoji, advantages of emoji questionnaires are summarised: &amp;ndash; enhanced ecological validity, familiarity and cross-culturally shared meanings. We then address concerns that hinder uptake of emoji questionnaires, including emoji meanings/interpretations, appropriateness for older consumers and ability to represent emotional arousal (activation to deactivation). Finally, we offer suggestions for how to accelerate the uptake of emoji questionnaires in sensory and consumer science, which include: i) more applied studies using emoji questionnaires, ii) establishing emoji meanings in the context of eating of drinking, iii) adopting open-ended question formats, iv) comparing emoji and emotion word questionnaires, and v) establishing guidelines for emoji questionnaires. An important spill-over benefit of research to develop emoji questionnaires is that it exposes the lack of similar research for emotion word questionnaires. We encourage colleagues in the field to engage in the task of conducting needed methodological research on emoji and emotion words alike.&#13;
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                <text>&lt;strong&gt;Jaeger, Sara R.&lt;/strong&gt;</text>
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                <text>The aim of the present work was to explore the effect of the inclusion of nutritional warnings on consumer associations with labels of ultra-processed products. The study was conducted in Uruguay at two points in time, before and after the compulsory implementation of nutritional warnings. A total of 163 participants evaluated three labels of ultra-processed products using a word association task. In the first evaluation (T1), performed 9 months before the entry into force of nutritional warnings, labels were presented without warnings. Nine months later (15 days after the entry into force of the policy), participants evaluated the labels with warnings again (T2). Data were analyzed using content analysis. At T1, when labels were presented without nutritional warnings, responses to the word association task were related to a description of the product category, expected sensory characteristics of the products, brand names, liking and eating occasions. However, when the labels were presented with the warnings at T2, a significant increase in the frequency of mention of responses was observed within the categories Excessive content of sugar/fat/sodium, Not healthy, Diseases and negative health conditions, Rejection to consume, and Unexpected information. Results from the present work suggest that immediately after their implementation, nutritional warnings cause a salience bias that make excessive nutrient content and its negative health consequences more salient in consumers&amp;rsquo; minds, especially in the case of products with a particular health-related connotation.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;em&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; &lt;/em&gt;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Significant sugar-reduction in dairy products targeted at children is possible without affecting hedonic perception&lt;/strong&gt;</text>
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                <text>&lt;p&gt;The objective of the present studywas to evaluate children's hedonic sensitivity to sugar reduction in three dairy products: vanilla milk desserts, chocolate-flavoured milk, and vanilla yoghurt. For each product, a regular sample and five samples with different reduction in added-sugar content were formulated. The regular sample contained the sugar content of commercial products available in the marketplace. The&lt;br /&gt;reduction in added-sugar content ranged between 10.0 and 41.0%. A total of 126 children (8e13 years old) participated in the study. An A-not A test was used to evaluate children's hedonic sensitivity to sugar reduction. Sugar reductions up to 27% in chocolate flavoured milk and vanilla yoghurt, and up to 19% in vanilla milk desserts, did not cause significant changes in children's hedonic reaction. These results confirm that sugar-reduction strategies can be easily implemented in the dairy industry without significant risk of affecting sample appreciation and market share.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt;&amp;nbsp;- La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The heteroatom doping of graphene is a useful method to amplify the outstanding properties of graphene. However, it is difficult to control the disposition of the dopants. By means of first-principles calculations, we show that the substrate-induced doping of epitaxial graphene leads to the formation of silicon doped graphene with a precise location of the dopants in the valley regions between crests. According to our results, in the valleys silicon dopants greatly prefer to replace the carbon atoms of the buffer layer which are bonded to the substrate by a large amount of energy. This selective doping suggests that a siligraphene layer in the g-SiC3 form would be an excellent model for a buffer layer grown on nanometer-sized areas of SiC, thus paving the way to the synthesis of a new two-dimensional material. We predict a stable antiferromagnetical (AF) ordering that behaves electronically as a semiconductor, degenerated with the highest ferromagnetic configuration of the system. A net magnetic moment of 0.65 &amp;mu;B per Si dangling bond was found for both the AF and the most stable ferromagnetic state of the SiC-siligraphene system. Finally, we demonstrate that quasi-free-standing epitaxial siligraphene layers on 6H-SiC(0001) could be obtained by the intercalation of argon atoms. We expect that this work can motivate new experimental studies pursuing the synthesis of SiC3 siligraphene.</text>
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                <text>A new method for the determination of silicon in Portland cement, based on the generation of volatile species without sample pre-treatment, is proposed. The method reduces operational complexity and time without loss of precision and with similar accuracy as the current methods. It employs microwave-assisted (domestic microwave oven) digestion to produce volatile silicon fluorides by reaction of the sample with a fluorinated salt (CaF2) in the presence of H2SO4 (98% w/w), using a Teflon&amp;reg; (PFA) reactor. The volatile fluorides are flushed out by a dry nitrogen stream and collected in 0.3 mol l&amp;minus;1 NaOH solution where they dissolve. Silicon is determined in this solution by flame atomic absorption spectrometry (FAAS). The recoveries are between 98 and 102%, and the precision is better than 2.5% relative standard deviation (R.S.D).</text>
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&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Simaroubaceae and Picramniaceae as potential sources of botanical pesticides&lt;/strong&gt;</text>
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                <text>Prospection for new sources of botanical pesticides has shown a revival in the last decades due not only to the fast development of resistance among different pests around the world but also by the need to use less eco-toxic products to control etiological agents of different pest-related problems found in agro-production. In this work, extracts from members of the families Simaroubaceae (Ailanthus altissima, Castela coccinea and Picrasma crenata) and Picramniaceae (Alvaradoa subovata and Picramnia sellowii) were evaluated for their toxicity against the cattle tick and for their antifeedant activity against insects. At the tested doses, none of the extracts exhibited a good toxicity against larvae of the common cattle tick. On the other hand, antifeedant activity was detected in various extracts. Foliage consumption was completely deterred in adults of the specialist Epilachna paenulata in the cases of the C. coccinea leaf and wood extracts and P. crenata wood extract. For larvae of the generalist Spodoptera frugiperda antifeedant effects were also detected, although in a lesser extent. Phytochemical analyses of the extracts showed the presence of alkaloids in P. crenata (including canthin-6-one) and in C. coccinea. Besides, GC/MS analyses of the wood extract from C. coccinea showed the presence of several steroids (ergot 5-en-3-ol-acetate, stigmastan-3,5 diene and stigmasta-3,5dien-7-one). Anthraquinones (emodin and chrysophanol) as well as chlorogenic acid were detected in the cases of A. subovata and P. sellowii extracts. The differences in deterrent activity could not be atributed to differences in the HPLC chemical profiles of the different extracts</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Simple Determination of 40 Organophosphate Pesticides in Raw Wool Using Microwave-Assisted Extraction and GC-FPD Analysis&lt;/strong&gt;</text>
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                <text>A validated analytical method for the multiresidue analysis of 40 organophosphate pesticides (OPs) and conversion products in raw wool has been developed. The method is based on the selective microwave-assisted extraction (MAE) of raw wool with acetonitrile and analysis of extracts by gas chromatography-flame photometric detector. The optimum MAE conditions were 20 min duration at 80 �C with 30 mL of acetonitrile per gram of wool. A validation study was performed according to the European SANCO guidelines 10684/2009. Limits of detection and quantification for all pesticides tested were from 0.01 to 0.2 mg/kg and from 0.2 to 1.0 mg/kg, respectively. The average recoveries of pesticides spiked at different levels were in the range of 70-120% with relative standard deviations of e20%. The extraction performance was compared to the one obtained with a reference Soxhlet extraction. The method was also applied in the analysis of real wool (after field application) samples.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;em&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege&lt;/strong&gt;&lt;/em&gt; el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A simulated therapeutic equivalence scenario was created between two multisource drug products (tablets marketed in Uruguay) containing a poorly water-soluble compound, flunitrazepam, and the reference product (Rohypnol&amp;reg;). The simulated study was built from an in vitro - in vivo dissolution-pharmacokinetic C-level (IVIV) correlation and from an in vivo pharmacokinetic-pharmacodynamic (PKPD) correlation, using experimental and bibliographic data. In vitro parameters were experimentally obtained from the dissolution profile for each commercial brand at the three biorelevant dissolution media (pH 1.2, 4.5 and 6.8) whereas in vivo parameters were acquired from the bibliography. From IVIV correlation plasma drug concentration-time profiles were simulated. These concentrations were used to simulate the intensity of drug effect throughout time in order to predict relative clinical responses of each brand. It could be concluded that from the three brands of flunitrazepam marketed in Uruguay, one was revealed as having a very poor sedative effect based on its simulated low pharmacodynamic-time profile, reinforcing hence the ineffective clinical experience claimed by physicians.</text>
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                <text>&lt;strong&gt;Magallanes, Laura&lt;/strong&gt;</text>
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                <text>Latin American Journal of Pharmacy v. 33, no. 1, 2014. -- p. 166-170</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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