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                <text>&lt;strong&gt;Sex- and smoke-related differences in gastrointestinal transit of cyclosporin A microemulsion capsules&lt;/strong&gt;</text>
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                <text>&lt;p&gt;The aim of this work was to study the effect of the sex and the smoking status on the pharmacokinetics and the bioequivalence assessment of a branded and a generic cyclosporine A microemulsion formulation in soft-gelatin capsule. Sixteen healthy volunteers (eight women and eight men) participated in a CyA bioequivalence study, with nine of the volunteers being smokers. Sandimmun Neoral� (brand formulation; Reference) and Sigmasporin Microral� (generic formulation; Test) were administered under fasting conditions. Pharmacokinetic parameters were calculated through non compartmental analysis. Bioequivalence was declared based on the 90% confidence intervals (90% CI) for the T/R ratio of the geometric means for each parameter. In vitro determination of the capsules opening time was performed in simulated gastric fluid without enzyme with USP Apparatus 2. The extent of absorption was similar between both products for all subjects or each sex-group. The absorption rate was similar for both products when considering all subjects, whereas a significant difference in the TMAX between the two products was observed for the male subjects only, which relates to its slower capsule opening time observed in vitro (12.4 versus 6.0 min). No differences were observed in women that could relate to their slower gastric emptying. Differences in drug exposure were observed between smokers and non-smokers. Sex- and smoke-related differences in the gastrointestinal transit should be considered when the on-set time would be determinant for the treatment success of a drug.&lt;/p&gt;</text>
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                <text>European Journal of Pharmaceutical Sciences&amp;nbsp; v. 63, 2014. -- p. 140-146</text>
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                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&lt;br /&gt;&lt;br /&gt;&lt;/p&gt;</text>
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                <text>http://dx.doi.org/10.1016/j.ejps.2014.07.006</text>
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                <text>&lt;strong&gt;Sex-by-formulation interaction assessed through a bioequivalence study of efavirenz tablets&lt;/strong&gt;</text>
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                <text>Although sex-related differences in gastrointestinal physiology have been vastly reported, its impact on drug oral&lt;br /&gt;bioavailability and bioequivalence (product discrimination) is often ignored. On this work results from an&lt;br /&gt;average bioequivalence study between tablets containing 600 mg of the antiretroviral efavirenz (EFV), carried&lt;br /&gt;out with 14 healthy subjects (8 female and 6 men) in a randomized 2-period, 2-treatment crossover design,&lt;br /&gt;are analyzed from a sex-based approach. Sequences were balanced within each sex group. Considering all&lt;br /&gt;subjects, no differences were observed on EFV absorbed amount, as shown by the estimated 90CI of the AUC96&lt;br /&gt;Test/Reference bioequivalence ratio (T/R): 0.950&amp;ndash;1.05. However, results were not conclusive due to the 90CI&lt;br /&gt;for CMAX T/R was 0.743&amp;ndash;1.07. Over this parameter, a significant sex-by-formulation interaction was detected:&lt;br /&gt;90CI CMAX T/R was 0.838&amp;ndash;1.36 in women and 0.540&amp;ndash;0.920 in men; with a 52% relative difference between&lt;br /&gt;point estimates. Formulation differences were therefore evidenced only by male subjects. In vitro dissolution&lt;br /&gt;and disintegration tests for both products were carried out in two aqueous media: A) SLS 0.25% and B) HCl/KCl&lt;br /&gt;pH 1.2. T/R results for dissolution efficiency and tablet disintegration times of formulations in both A and B&lt;br /&gt;media were highly correlated with CMAX T/R bioequivalence results observed in women and men respectively,&lt;br /&gt;showing that a dissimilar gastrointestinal environment between sexes affected EFV oral absorption. This work&lt;br /&gt;shows how sex-by-formulation interaction can affect bioequivalence conclusions. Sex effect on product discrimination&lt;br /&gt;should be specially disclosed in bioequivalence studies, mainly for drugs aimed to be given to both sexes.</text>
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                <text>&lt;strong&gt;Ibarra, Manuel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Magallanes, Laura&lt;/strong&gt;</text>
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                <text>European Journal of Pharmaceutical Sciencesv. 85, 2016. -- p. 106-111</text>
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                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>http://dx.doi.org/10.1016/j.ejps.2016.02.001</text>
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                <text>&lt;strong&gt;Sex-related in vitro/in vivo and PK/PD correlations after oral single dose furosemide administration&lt;/strong&gt;</text>
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                <text>PRODUCTOS FARMACEUTICOS</text>
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                <text>Background: The goal of this study was to develop an in vivo-in vitro (IVIV) correlation, both in men and women, which allows constructing a model to predict bioequivalence assessments for drugs with narrow absorption windows. Besides, pharmacokinetic and pharmacodynamic equivalences were also investigated. Furosemide was chosen as a prototype. Methods: Twelve healthy Caucasian volunteers (8 women and 4 men) participated in a relative bioavailability study. Two oral formulations [Lasix&amp;reg; (Reference, R) and Furosemide EFA&amp;reg; (Test, T)] were administered under fasting conditions. Urinary excretion of unchanged drug (PK), and of chloride, sodium and potassium (PD) wasmonitored throughout time. PK and PD parameters were calculated from each respective excretion rate versus time curve. In vitro dissolution testing of both formulations was carried out using the USP apparatus 2 and 4 with fixed and variable dissolution media. Results: T and R could be considered bioequivalent since the 90% confidence intervals for the T/R ratio of geometric means for the area under the urinary drug excretion rate versus time curve and for the maximum excretion rate were within the 0.80-1.25 bioequivalence interval. However, T had faster initial absorption and higher levels in women, while R displayed such characteristics in men. Closer IVIV correlations in women were obtained when apparatus 4 with variable biorelevant dissolution media were used [going from fasting state simulated gastric fluid to fasting state simulated intestinal fluid]. Since R had faster disintegration time than T, a shorter stay of R under gastric conditions was required in order to obtain a good IVIV correlation in men. Saluretic effect displayed a typical clockwise hysteresis loop for the PKPD correlation assessed through chloride-versus-furosemide urinary excretion rates. Even though a higher amount of furosemide was excreted with the urine in men, differences in the excretion of electrolytes between sexes were almost negligible. Conclusions: Sex-differences in the gastrointestinal transit of formulations, under fasting conditions, determined the extent and the rate of furosemide absorption. The prolongation of the absorption process by mean of slowing the gastric emptying would make the formulation more effective. The USP-4 apparatus with variable dissolution media was able to discriminate the formulations even between sexes, becoming a promissory in vitro dissolution testing to predict bioequivalence.</text>
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                <text>&lt;strong&gt;Magallanes, Laura&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fotaki, Nikoletta&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Barindelli, Anna&lt;/strong&gt;</text>
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                <text>Journal of Pharmaceutical Technology &amp;amp; Drug Research v. 5, no. 2, 2016.-- 11p.</text>
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                <text>HOAJ</text>
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              <elementText elementTextId="424256">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI : http://dx.doi.org/10.7243/2050-120X-5-2</text>
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                <text>&lt;strong&gt;Sexually transmitted chemical defense in a moth (Utetheisa ornatrix).&lt;/strong&gt;</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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            <description>A summary of the resource.</description>
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                <text>The arctiid moth Utetheisa ornatrix is protected against predation by pyrrolizidine alkaloids (PA) that it sequesters as a larva from its food plant. Earlier work had shown that males transmit PA to the female with the sperm package and that the female bestows part of this gift on the eggs, protecting these against predation as a result. We now show that the female herself derives protection from the gift. Females deficient in PA are vulnerable to predation from spiders (Lycosa ceratiola and Nephila clavipes). If mated with a PA-laden male, the females become unacceptable as prey. The effect takes hold promptly and endures; females are unacceptable to spiders virtually from the moment they uncouple from the male and remain unacceptable as they age. Chemical data showed that the female allocates the received PA quickly to all body parts. We predict that other instances will be found of female insects being rendered invulnerable by receipt of sexually transmitted chemicals.</text>
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                <text>&lt;a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8ca340da794ac0eade285d2d2721ec5d"&gt;&lt;strong&gt;Gonz&amp;aacute;lez, A&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt; Eisner, M&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Eisner, T&lt;/strong&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Proceedings at the National Academy of Science USA v. 96, no. 10, 1999. -- p. 5570-5574</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>The National Academy of Sciences</text>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="311006">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Background: Aptamers represent an emerging class of oligonucleotides that have the ability to bind ligands with high affinity. Sgc8-c aptamer recognizes PTK7, a member of the catalytically defective receptor protein tyrosine kinase family that is upregulated in various cancers, including hemato-oncological malignancies. Herein, an Sgc8-c-NOTA-radiolabeled probe was prepared for theranostic purpose. Materials and Methods: In this work, an Sgc8-c-radiolabeled probe against PTK7 was prepared, and biological evaluations&amp;mdash;pharmacokinetic studies, biodistribution analysis, and in vivo molecular imaging&amp;mdash;were performed. To obtain the radiolabeled probe, a modified 5&amp;prime;-amino-derivative of the Sgc8-c aptamer was bound to the metal chelator NOTA, and subsequently labeled with 67Ga with high yield and radiochemical purity. The precursor, Sgc8-c-NOTA, the radio probe Sgc8-c-NOTA-67Ga, and its nonradioactive complex, Sgc8-c-NOTA-69/71Ga, were purified by reverse-phase high-performance liquid chromatography and characterized by electrospray ionization mass spectrometry. The binding ability of Sgc8-c-NOTA-67Ga was studied in vitro against purified PTK7 receptor. In addition, the binding was also evidenced against the hemato-oncological A20 cell line, derived from B lymphocytes, and the corresponding A20-green fluorescent protein (GFP)-transfected cells. The proof of concept was performed on A20-GFP tumor-bearing mice, in which the biodistribution of the radiolabeled probe was evaluated through imaging, using X-ray, fluorescence, and &amp;gamma; modalities. The specific uptake of the probe was confirmed by blocking with the Sgc8-c aptamer in an in vivo competition assay. Results: The biodistribution results showed considerable uptake in tumor since 2&amp;thinsp;h, with highest at 48&amp;thinsp;h postinjection. However, the blood and muscle ID/g (injected dose per gram of tissue) activities were decreasing with time and tumor/no-target ratios increasing to 20 at 24&amp;thinsp;h postinjection. These results are consistent with the in vivo images. Conclusions: This study supports the utility of Sgc8-c-NOTA radiolabeled as a theranostic agent.</text>
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                <text>&lt;strong&gt;Cerecetto, Hugo&lt;/strong&gt;</text>
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                <text>Cancer Biotheraphy and Radiopharmaceuticals v. 35,no. 4, 2020. -- p. 262-270</text>
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                <text>&lt;span&gt;Mary Ann Liebert&lt;/span&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor sobre toda creaci&amp;oacute;n&lt;/strong&gt; literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>In this study three different approaches&amp;mdash;acceptability limit, failure cut-off point methodology, and survival analysis&amp;mdash;to estimate the sensory shelf life of brown pan bread elaborated with different enzymes using consumer data were compared. The study was carried out in Spain and Uruguay independently, where four batches of bread were produced, with the same base formulation, one without enzyme, the others with the addition of maltogenic amylase, xylanase, and a mixture of both. The results showed that for Uruguayan consumers the mixture of enzymes provided better results in extending shelf life than the addition of amylase alone. For the Spanish consumers only the addition of amylase provided the desired results, and for consumers of both countries the use of xylanase did not extend the shelf life of bread. Among the methodologies used for the estimation, survival analysis provided the most adequate predictions considering consumer rejection of the product. Hedonic scales do not always reflect consumer behaviour when deciding whether to accept or reject a certain product for its consumption.</text>
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                <text>&lt;a title="Curr&amp;iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=c2b879ed74672c10135cd7d40d21e3aa" target="_blank"&gt;&lt;strong&gt;Gim&amp;eacute;nez, Ana&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Varela, Paula&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Salvador, Ana&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fiszman, S.M&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Garitta, Lorena&lt;/strong&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Food Quality and Preference v.18, no. 2, 2007. -- p.196-204</text>
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                <text>Elsevier</text>
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            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="268807">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>T wo monovarietal extra virgin olive oils (Arbequina and Coratina), produced in Uruguay, were studied over a period of 12 months storage in amber bottles at 30 &amp;ordm;C. P eroxide index, K 232 , K 270 , ∆K, OSI induction time did not exceed the maximum limits set by the International Olive Council (IOC ) during the entire period. However, the content of ethyl esters increase d with storage time and it is in relation with the shelf life. The International Olive Council (IOC) establishes the limits in the content of ethyl esters &amp;le; 35 ppm. T he Coratina oil ceased to be extra virgin quality after 6 months of storage due to its content of ethyl esters (46 ppm), and the Arbequina oil after 9 mo nths (52 ppm). Taking into consideration their content of ethyl esters, both the Arbequina and Coratina oils showed a very short shelf life less than six months. T he determination of ethyl ester content proved to be a sensitive method for determining the l oss of quality of extra virgin olive oils</text>
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                <text>Small compounds cannot bind simultaneously to two antibodies, and thus, their immunodetection is limited to competitive formats in which the analyte is indirectly quantitated by measuring the unoccupied antibody binding sites using a competing reporter. This limitation can be circumvented by using phage-borne peptides selected for their ability to specifically react with the analyte&amp;ndash;antibody immunocomplex, which allows the detection of these small molecules in a noncompetitive format (PHAIA) with increased sensitivity and a positive readout. In an effort to find substitutes for the phage particles in PHAIA, we explore the use of the B subunit of the Shiga-like toxin of Escherichia coli, also known as verotoxin (VTX), as a scaffold for multivalent display of anti-immunocomplex peptides. Using the herbicides molinate and clomazone as model compounds, we built peptide&amp;ndash;VTX recombinant chimeras that were produced in the periplasmic space of E. coli as soluble pentamers, as confirmed by multiangle light scattering analysis. These multivalent constructs, which we termed nanopeptamers, were conjugated to a tracer enzyme and used to detect the herbicide&amp;ndash;antibody complex in an ELISA format. The VTX&amp;ndash;nanopeptamer assays performed with over a 10-fold increased sensitivity and excellent recovery from spiked surface and mineral water samples. The carbon black-labeled peptide&amp;ndash;VTX nanopeptamers showed great potential for the development of a lateral-flow test for small molecules with a visual positive readout that allowed the detection of up to 2.5 ng/mL of clomazone.</text>
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                <text>Analytical Chemistry v. 86, no.11, 2014. -- p. 5541-5546</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;Here, we report a joint experimental and theoretical study using molecular dynamics calculations focusing on short- and long-range structure correlations with ionic transport near the glass transition for lithium-ion polyacrylonitrile-&lt;br /&gt;based electrolytes using DMSO as plasticizer. The presence of subtle modifications of the polymeric structural features near the glass transition (Tg) is rarely reported in the literature and could be relevant to study free volume in polymer-based electrolytes. Our in-situ small angle X-ray scattering (SAXS) analysis at different temperatures evidence an increment of free volume and partial loss of long-range coherence between polyacrylonitrile neighbor chains just above Tg in strong correlation with an Arrhenius behavior crossover observed&lt;br /&gt;for the ionic transport in these polyacrylonitrile-based electrolytes. Advancing the understanding of lithium-ion&lt;br /&gt;conductivity Arrhenius behavior for polymeric electrolytes with Tg slightly above room temperature could be of great relevance due to the overlap with the operating temperature range of lithium-ion batteries.&lt;/p&gt;</text>
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&lt;p dir="ltr"&gt;&lt;span&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/span&gt;&lt;/p&gt;&#13;
&lt;p dir="ltr"&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derechode autor&lt;/strong&gt;&lt;span&gt;&amp;nbsp;sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/span&gt;&lt;/p&gt;&#13;
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                <text>Emotion word questionnaires remain dominant in food-related emotion research despite acknowledged limitations. Emoji questionnaires can overcome some of these limitations but are not yet regarded as a strong alternative to emotion word questionnaires. We believe they have the potential to earn this right and use this invited opinion piece to explain why. Following a brief introduction about emoji, advantages of emoji questionnaires are summarised: &amp;ndash; enhanced ecological validity, familiarity and cross-culturally shared meanings. We then address concerns that hinder uptake of emoji questionnaires, including emoji meanings/interpretations, appropriateness for older consumers and ability to represent emotional arousal (activation to deactivation). Finally, we offer suggestions for how to accelerate the uptake of emoji questionnaires in sensory and consumer science, which include: i) more applied studies using emoji questionnaires, ii) establishing emoji meanings in the context of eating of drinking, iii) adopting open-ended question formats, iv) comparing emoji and emotion word questionnaires, and v) establishing guidelines for emoji questionnaires. An important spill-over benefit of research to develop emoji questionnaires is that it exposes the lack of similar research for emotion word questionnaires. We encourage colleagues in the field to engage in the task of conducting needed methodological research on emoji and emotion words alike.&#13;
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                <text>&lt;strong&gt;Jaeger, Sara R.&lt;/strong&gt;</text>
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                <text>Food Quality and Preference 2020.-- p. 1-5.-- https://doi.org/10.1016/j.foodqual.2020.104121&#13;
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                <text>The aim of the present work was to explore the effect of the inclusion of nutritional warnings on consumer associations with labels of ultra-processed products. The study was conducted in Uruguay at two points in time, before and after the compulsory implementation of nutritional warnings. A total of 163 participants evaluated three labels of ultra-processed products using a word association task. In the first evaluation (T1), performed 9 months before the entry into force of nutritional warnings, labels were presented without warnings. Nine months later (15 days after the entry into force of the policy), participants evaluated the labels with warnings again (T2). Data were analyzed using content analysis. At T1, when labels were presented without nutritional warnings, responses to the word association task were related to a description of the product category, expected sensory characteristics of the products, brand names, liking and eating occasions. However, when the labels were presented with the warnings at T2, a significant increase in the frequency of mention of responses was observed within the categories Excessive content of sugar/fat/sodium, Not healthy, Diseases and negative health conditions, Rejection to consume, and Unexpected information. Results from the present work suggest that immediately after their implementation, nutritional warnings cause a salience bias that make excessive nutrient content and its negative health consequences more salient in consumers&amp;rsquo; minds, especially in the case of products with a particular health-related connotation.</text>
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                <text>La present. Monografla Tecnic&amp;amp; valora el significado que presenta la comjugaci6n de los f1=~acos y de las sustancias ennd6genas de bajo peso molecular c ~ las protelnas plasmaticas. Este estudio puede dividirse e~ tres grandes grupos. El prl mero versa sobre aspectos te6ri:_~ er. general,ta~tc farmaco16g1 cos como fisicoqulmicos. Se senalLa las interrrelaciones entreela proteoconjugaci6n y los aspect:s generales de la farmacolog1a, como el pasaje de los far~a::s atrav~s de las membranas corporales, la absorci6n gastroi~:estinal, la biodisponibilidad de la forma farmaceutica adminis:~ada, la distribuci6n del rarrmaco en el organismo, la respues:a farmacodinamica, la5 manire~ taciones t6xicas, y la eliminaci5~ del farmaco y sus metabolitos; a la vez que se destaca la ~?ortancia de la interrrelaci6n entre la conjugaci6n farmaco-pro:einas plasmlticas con la rarm~ cocinetica. nesde un punto de vis:. fisicoqulmico se consideraael tratamiento y presentaci6n de iatos experimentales, 105 ~et&amp;pound; dos experiment~l~s para detectar : cUL~tiricar la interacci6n &amp;eth;108 aspectos fisicoqulmicos r,:a:ionados con el enlace quimiico que se establece, la relaci6n e~tre la conjugaci6n y la lip&amp;pound; solubilidad del~armaco, y de ~': JS con 10s aspectos generales- de la farmacologia, a la vez q~e S! senalan los fundamentos deela interacci6n medicamentosa a rt~ve: de los lugares de fijaci6n de 105 farmacos alas proteinas pla;~ticas. En la segunda parte de la &amp;yen;.ono~afia Tecnica se estudian en general alas proteinas del plas~a ~umano y alas proteinas deelos elementos figuradoB de !a san~., y en particular a las pr~ telnas que participan activ~ente e~ 1. conjugaci6n de los f&amp;pound;rrmacos y de las sllstancias end6gena; de bajo peso molecular. Essconsiderada la interrelaci6n entre :irmacos y proteinas plasm! ticas.que por modificar las propieiades de estas ultimas,geneeran aceiones farmaco16gicas de uti~dad clinica. La aplicaci6n de 10 expuesto se estudia en la parte final `de la Monografla T'cnica, habiendcse seleccionado cuatro imporrtantes grupos farmaco16gicos, no ta:iendolo podido hacer en otros grupos no menos importantes ~~e los elegidos, por limitaaci6n de texto.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>&lt;p&gt;&lt;em&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; &lt;/em&gt;&lt;/p&gt;&#13;
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                <text>&lt;strong&gt;Significant sugar-reduction in dairy products targeted at children is possible without affecting hedonic perception&lt;/strong&gt;</text>
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                <text>&lt;p&gt;The objective of the present studywas to evaluate children's hedonic sensitivity to sugar reduction in three dairy products: vanilla milk desserts, chocolate-flavoured milk, and vanilla yoghurt. For each product, a regular sample and five samples with different reduction in added-sugar content were formulated. The regular sample contained the sugar content of commercial products available in the marketplace. The&lt;br /&gt;reduction in added-sugar content ranged between 10.0 and 41.0%. A total of 126 children (8e13 years old) participated in the study. An A-not A test was used to evaluate children's hedonic sensitivity to sugar reduction. Sugar reductions up to 27% in chocolate flavoured milk and vanilla yoghurt, and up to 19% in vanilla milk desserts, did not cause significant changes in children's hedonic reaction. These results confirm that sugar-reduction strategies can be easily implemented in the dairy industry without significant risk of affecting sample appreciation and market share.&lt;/p&gt;</text>
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                <text>International Dairy Journal&amp;nbsp;v. 114, 2021. -- e104937</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&amp;nbsp;protege el derecho de autor&lt;/strong&gt;&amp;nbsp;sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt;&amp;nbsp;- La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The heteroatom doping of graphene is a useful method to amplify the outstanding properties of graphene. However, it is difficult to control the disposition of the dopants. By means of first-principles calculations, we show that the substrate-induced doping of epitaxial graphene leads to the formation of silicon doped graphene with a precise location of the dopants in the valley regions between crests. According to our results, in the valleys silicon dopants greatly prefer to replace the carbon atoms of the buffer layer which are bonded to the substrate by a large amount of energy. This selective doping suggests that a siligraphene layer in the g-SiC3 form would be an excellent model for a buffer layer grown on nanometer-sized areas of SiC, thus paving the way to the synthesis of a new two-dimensional material. We predict a stable antiferromagnetical (AF) ordering that behaves electronically as a semiconductor, degenerated with the highest ferromagnetic configuration of the system. A net magnetic moment of 0.65 &amp;mu;B per Si dangling bond was found for both the AF and the most stable ferromagnetic state of the SiC-siligraphene system. Finally, we demonstrate that quasi-free-standing epitaxial siligraphene layers on 6H-SiC(0001) could be obtained by the intercalation of argon atoms. We expect that this work can motivate new experimental studies pursuing the synthesis of SiC3 siligraphene.</text>
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                <text>Journal of Physical Chemistry C v. 123, no. 50, 2019. -- p. 30341-30350</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A new method for the determination of silicon in Portland cement, based on the generation of volatile species without sample pre-treatment, is proposed. The method reduces operational complexity and time without loss of precision and with similar accuracy as the current methods. It employs microwave-assisted (domestic microwave oven) digestion to produce volatile silicon fluorides by reaction of the sample with a fluorinated salt (CaF2) in the presence of H2SO4 (98% w/w), using a Teflon&amp;reg; (PFA) reactor. The volatile fluorides are flushed out by a dry nitrogen stream and collected in 0.3 mol l&amp;minus;1 NaOH solution where they dissolve. Silicon is determined in this solution by flame atomic absorption spectrometry (FAAS). The recoveries are between 98 and 102%, and the precision is better than 2.5% relative standard deviation (R.S.D).</text>
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                <text>&lt;strong&gt;Pignalosa, G&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rouco, V&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Vazquez, L&lt;/strong&gt;</text>
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                <text>Spectrochimica Acta B. v. 56, no. 10, 2001. -- p. 1995-99</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Simaroubaceae and Picramniaceae as potential sources of botanical pesticides&lt;/strong&gt;</text>
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                <text>Prospection for new sources of botanical pesticides has shown a revival in the last decades due not only to the fast development of resistance among different pests around the world but also by the need to use less eco-toxic products to control etiological agents of different pest-related problems found in agro-production. In this work, extracts from members of the families Simaroubaceae (Ailanthus altissima, Castela coccinea and Picrasma crenata) and Picramniaceae (Alvaradoa subovata and Picramnia sellowii) were evaluated for their toxicity against the cattle tick and for their antifeedant activity against insects. At the tested doses, none of the extracts exhibited a good toxicity against larvae of the common cattle tick. On the other hand, antifeedant activity was detected in various extracts. Foliage consumption was completely deterred in adults of the specialist Epilachna paenulata in the cases of the C. coccinea leaf and wood extracts and P. crenata wood extract. For larvae of the generalist Spodoptera frugiperda antifeedant effects were also detected, although in a lesser extent. Phytochemical analyses of the extracts showed the presence of alkaloids in P. crenata (including canthin-6-one) and in C. coccinea. Besides, GC/MS analyses of the wood extract from C. coccinea showed the presence of several steroids (ergot 5-en-3-ol-acetate, stigmastan-3,5 diene and stigmasta-3,5dien-7-one). Anthraquinones (emodin and chrysophanol) as well as chlorogenic acid were detected in the cases of A. subovata and P. sellowii extracts. The differences in deterrent activity could not be atributed to differences in the HPLC chemical profiles of the different extracts</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>A validated analytical method for the multiresidue analysis of 40 organophosphate pesticides (OPs) and conversion products in raw wool has been developed. The method is based on the selective microwave-assisted extraction (MAE) of raw wool with acetonitrile and analysis of extracts by gas chromatography-flame photometric detector. The optimum MAE conditions were 20 min duration at 80 �C with 30 mL of acetonitrile per gram of wool. A validation study was performed according to the European SANCO guidelines 10684/2009. Limits of detection and quantification for all pesticides tested were from 0.01 to 0.2 mg/kg and from 0.2 to 1.0 mg/kg, respectively. The average recoveries of pesticides spiked at different levels were in the range of 70-120% with relative standard deviations of e20%. The extraction performance was compared to the one obtained with a reference Soxhlet extraction. The method was also applied in the analysis of real wool (after field application) samples.</text>
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                <text>&lt;strong&gt;Niell, Silvina&lt;/strong&gt;</text>
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                <text>Journal of Agricultural and Food Chemistry&amp;nbsp; v. 59, no. 14, 2011. -- p. 7601-7608</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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