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                <text>The inositol phosphates are ubiquitous metabolites in eukaryotes, of which the most abundant are inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5)]. These two compounds, poorly understood functionally, have complicated complexation and solid formation behaviours with multivalent cations. For InsP6, we have previously described this chemistry and its biological implications (Veiga et al. in J Inorg Biochem 100:1800, 2006; Torres et al. in J Inorg Biochem 99:828, 2005). We now cover similar ground for Ins(1,3,4,5,6)P5, describing its interactions in solution with Na?, K?, Mg2?, Ca2?, Cu2?, Fe2? and Fe3?, and its solid-formation equilibria with Ca2? and Mg2?. Ins(1,3,4,5,6)P5 forms soluble complexes of 1:1 stoichiometry with all multivalent cations studied. The affinity for Fe3? is similar to that of InsP6 and inositol 1,2,3-trisphosphate, indicating that the 1,2,3- trisphosphate motif, which Ins(1,3,4,5,6)P5 lacks, is not absolutely necessary for high-affinity Fe3? complexation by inositol phosphates, even if it is necessary for their prevention of the Fenton reaction. With excess Ca2? and Mg2?, Ins(1,3,4,5,6)P5 also forms the polymetallic complexes [M4(H2L)] [where L is fully deprotonated Ins(1,3,4,5,6)P5]. However, unlike InsP6, Ins(1,3,4,5,6)P5 is predicted not to be fully associated with Mg2? under simulated cytosolic/ nuclear conditions. The neutral Mg2? and Ca2? complexes have significant windows of solubility, but they precipitate as [Mg4(H2L)]�23H2O or [Ca4(H2L)]�16H2O whenever they exceed 135 and 56 lM in concentration, respectively. Nonetheless, the low stability of the [M4(H2L)] complexes means that the 1:1 species contribute to the overall solubility of Ins(1,3,4,5,6)P5 even under significant Mg2? or Ca2? excesses. We summarize the solubility behaviour of Ins(1,3,4,5,6)P5 in straightforward plots</text>
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                <text>Mini- Reviews in Medicinal Chemistry v. 5, no. 5, 2005. -- p. 499-519</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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                <text>The concurrent use of CATA questions (check-all-that-apply) with hedonic scaling in product research with consumers has gained acceptance in recent years. However, CATA questions do not enable product developers to identify consumers&amp;rsquo; preferred intensity of a sensory attribute directly, and for this reason just-about-right (JAR) questions are sometimes used together with questions that quantify attribute presence and/or intensity. Using JAR questions, consumers have to describe each of the samples in terms of each specific attribute, typically: 1 = &amp;lsquo;Not enough&amp;hellip;&amp;rsquo;, 3 = &amp;lsquo;Just about right&amp;rsquo;, and 5 = &amp;lsquo;Much too&amp;hellip;&amp;rsquo;. Past research has suggested that co-elicitation of hedonic and JAR responses bias the hedonic data. This undesired effect could extend to the case where JAR questions are used concurrently with hedonic and CATA questions. In seven studies (N = 762) across seven product categories no such evidence was found. Additionally, there was some evidence pointing to an increase in product discrimination based on hedonic and CATA responses. Preliminary data indicated that the inclusion of JAR questions in product tests also eliciting hedonic and CATA responses did not negatively affect consumers&amp;rsquo; perception of the task, which, on average, was still regarded as easy and not tedious. Future research is required to validate the findings across more varied experimental settings.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Acetonitrile-1&amp;kappa;N)[&amp;mu;-1H-benzimidazole-2(3H)-thione-1:2&amp;kappa;2 S:S][1H-benzimidazole-2(3H)-thione-2&amp;kappa;S]bis(&amp;mu;-1,1-dioxo-1&amp;lambda;6,2-benzothiazole-3-thiolato-1:2&amp;kappa;2S3:N;1:2&amp;kappa;2 S3:S3)-dicopper(I)(Cu-Cu), [Cu2(C7H4NO2S2)2(C7H6N2S)2(CH3CN)] or [Cu2(tsac)2(Sbim)2(CH3CN)] [tsac is thiosaccharinate and Sbim is 1H-benzimidazole-2(3H)-thione], (1), is a new copper(I) compd. that consists of a triply bridged dinuclear Cu-Cu unit. In the complex mol., two tsac anions and one neutral Sbim ligand bind the metals. One anion bridges via the endocyclic N and exocyclic S atoms (&amp;mu;-S:N). The other anion and one of the mercaptobenzimidazole mols. bridge the metals through their exocyclic S atoms (&amp;mu;-S:S). The 2nd Sbim ligand coordinates in a monodentate fashion (&amp;kappa;S) to one Cu atom, while an acetonitrile mol. coordinates to the other Cu atom. The CuI-CuI distance [2.6286(6) &amp;Aring;] can be considered a strong cuprophilic interaction. In the case of [&amp;mu;-1H-benzimidazole-2(3H)-thione-1:2&amp;kappa;2 S:S]bis[1H-benzimidazole-2(3H)-thione]-1&amp;kappa;S;2&amp;kappa;S-bis(&amp;mu;-1,1-dioxo-1&amp;lambda;6,2-benzothiazole-3-thiolato)-1:2&amp;kappa;2 S3:N;1:2&amp;kappa;2S3:S3-dicopper(I) (Cu-Cu), [Cu2(C7H4NO2S2)2(C7H6N2S)3] or [Cu2(tsac)2(Sbim)3] (2), the acetonitrile mol. is substituted by an addnl. Sbim ligand, which binds one Cu atom via the exocylic S atom. In this case, the CuI-CuI distance is 2.606&lt;/p&gt;</text>
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                <text>Acta Crystallographica Section C v. 68, no 1, 2012. -- p. m12-m16</text>
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                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&lt;br /&gt;&lt;br /&gt;&lt;/p&gt;&#13;
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                <text>&lt;strong&gt;The content of Instagram posts featuring ultra-processed products through the lens of the heuristic-systematic model&lt;/strong&gt;</text>
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                <text>Digital marketing has seen a rapid rise in the last decade as a consequence of the increased popularity of social media. However, few studies so far have analyzed the prevalence and persuasive power of digital marketing of ultra-processed products. The present study aimed at: (i) analyzing the content of Instagram posts of ultra processed products through the lens of the heuristic-systematic model, and (ii) evaluating the influence of the content of the posts on user interactions. A search for Instagram accounts of ultra-processed products was per formed using a master list of products commercialized in the two most popular online supermarkets in Uruguay. For each of the identified Instagram accounts, all the content posted in a 6-month period was recorded (August 15th, 2020 to February 15th, 2021). The posts were analyzed using content analysis based on inductive coding, and gradient boosting models (GBMs) were used to address the second study objective. A total of 2178 Instagram posts promoting specific ultra-processed products or brands were identified. The posts included a diverse set of cues to trigger both systematic and heuristic processing. References to the pleasure derived from product con sumption as well as health-related cues were most prevalent. The GBM showed that references to contests and raffles and invitations to interact encouraged users to engage with the posts through posting comments. Taken together, results stress the need to implement comprehensive regulatory approaches to reduce exposure to and the power of digital marketing of ultra-processed products given the harmful health-related consequences associated with excessive consumption of such products</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;Objective: The aim of this study was to explore and analyse the actions implemented by civil society to contribute to food security in the context of the COVID-19 outbreak in Uruguay, a high-income country in South America.&lt;br /&gt;Design: An exploratory systematic approach was used to identify the contributions of civil society to food security through reports in news websites and Facebook&lt;br /&gt;posts. Data were analysed based on content analysis following a deductive&amp;ndash;inductive approach.&lt;br /&gt;Setting: Uruguay, Latin America.&lt;br /&gt;Results: A total of 1220 civil society organisations were identified, which developed two main actions to increase access to food among the Uruguayan population: food baskets and &amp;lsquo;community pots&amp;rsquo; (also known as &amp;lsquo;common pots&amp;rsquo;). Most of the&lt;br /&gt;initiatives targeted citizens under socioeconomic vulnerability in the face of COVID-19, without specifying any specific requirement or population segment.&lt;br /&gt;Actions were mainly led by spontaneously organised community groups, and, to a lesser extent, by consolidated organisations. Interactions between organisations were identified. The foods provided by the organisations were mostly aligned with national dietary guidelines. Social media posts evidenced that the main challenge faced by organisations was related to the lack of funds or supplies.&lt;br /&gt;Conclusions: Results from this work suggest that the lack of funds or supplies poses challenges to the medium- and long-term contributions of civil society to food security and stresses the need for comprehensive governmental measures to guarantee food security amongst Uruguayan citizens.&lt;/p&gt;</text>
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                <text>In this study, activated biochar was produced using pilot-scale technologies of fast pyrolysis and activation to create desirable morphology, surface chemistry, and adsorptive properties for application in supercapacitors. First, residues from white birch were converted into biochar by fast pyrolysis (~ 450 &amp;deg;C). Then, physical (using CO2) or chemical (using KOH) activation was carried out in a homemade pilot-scale furnace at 900 &amp;deg;C. These synthesized materials presented distinct porosity structures: micro-/mesoporous (CO2 material) and highly microporous (KOH material), reaching surface areas of up to 1700 m2 g&amp;minus;1. Electrochemical results showed that KOH-activated biochar had higher specific electrical capacitance in both acidic and neutral electrolytes with a maximum specific capacitance value of 350 and 118 F g&amp;minus;1 at 1 A g&amp;minus;1, respectively; while, for CO2-activated biochar, the maximum obtained values were 204 and 14 F g&amp;minus;1. The greater proportion of oxygenated and nitrogenated functional groups on the surface of the KOH activated biochar, along with its high surface area (with wider porosity), improved its performance as a supercapacitor electrode. Specifically, the low proportion of ultramicropores was determinant for its better electrochemical behavior, especially in the neutral electrolyte. Indeed, these results are similar to those found in the literature on the electrical capacitance of carbonaceous materials synthesized in a small-scale furnace. Thus, the chemical-activated biochar made from wood residues in pilot-scale furnaces is a promising material for use as electrodes for supercapacitors.</text>
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                <text>The novel Re(II) complex NBu4[Re(NO)Br4(Hnic)] (1) and the heterodinuclear compounds [Re(NO)Br4(&amp;mu;-nic)Ni(dmphen)2]&amp;middot;&amp;frac12;CH3CN (2), [Re(NO)Br4(&amp;mu;-nic)Co(dmphen)2]&amp;middot;&amp;frac12;MeOH (3), [Re(NO)Br4(&amp;mu;-nic)Mn(dmphen)(H2O)2]&amp;middot;dmphen (4), [Re(NO)Br4(&amp;mu;-nic)Cu(bipy)2] (5) [Re(NO)Br4(&amp;mu;-nic)Cu(dmphen)2] (5&amp;prime;) (NBu4+ = tetra-n-butylammonium cation, Hnic = 3-pyridinecarboxylic acid, dmphen = 2,9-dimethyl-1,10-phenanthroline, bipy = 2,2&amp;prime;-bipyridine) have been prepared and the structures of 1&amp;ndash;5 determined using single crystal X-ray diffraction. The structure of 1 consists of [Re(NO)Br4(Hnic)]&amp;minus; anions and NBu4+ cations. Each Re(II) is six-coordinate with four bromide ligands, a linear nitrosyl group and a nitrogen atom from the Hnic molecule, in a distorted octahedral surrounding. The structures of 2&amp;ndash;5 are made up of discrete heterodinuclear Re(II)M(II) units where the fully deprotonated [Re(NO)Br4(nic)]2&amp;minus; entity acts as a didentate ligand through the carboxylate group towards the [Ni(dmphen)2]2+ (2), [Co(dmphen)2]2+ (3), [Mn(dmphen)(H2O)2]2+ (4) and [Cu(bipy)2]2+ (5) fragments, the Re&amp;ndash;M separation across the nic bridge being 7.8736(8) (2), 7.9632(10) (3), 7.7600(6) (4) and 8.2148(7) &amp;Aring; (5). The environment of the Re(II) ion in 2&amp;ndash;5 is the same as that in 1 and all M(II) are six-coordinate in highly distorted octahedral surroundings, the main source of the distortion being due to the reduced bite of the chelating carboxylate. The magnetic properties of 1&amp;ndash;5&amp;prime; were investigated in the temperature range 1.9&amp;ndash;300 K. 1 behaves as a quasi-magnetically isolated spin doublet with very weak antiferromagnetic interactions through space Br⋯Br contacts. Its magnetic susceptibility data were successfully modeled through a deep analysis of the influence of the ligand field, spin&amp;ndash;orbit coupling, tetragonal distortion and covalence effects as variable parameters. Compounds 2&amp;ndash;5&amp;prime; exhibit weak antiferromagnetic interactions. The intramolecular exchange pathway in this family being discarded because of the symmetry of magnetic orbitals of the Re(II) ion (dxy) precludes any spin delocalization on the bridging nic orbitals, the observed magnetic interactions are most likely mediated by &amp;pi;&amp;ndash;&amp;pi; type interactions between the peripheral ligands which occur in them. Only in the case of 4, short through space Br⋯Br contacts of ca. 4.03 &amp;Aring; (values larger than 5.5 &amp;Aring; in 2, 3 and 5) could be involved in the exchange coupling.</text>
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                <text>&lt;strong&gt;Julve, Miguel&lt;/strong&gt;</text>
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                <text>Dalton Transactions v. 44, no. 25, 2015. -- p. 11636-11648</text>
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                <text>Royal Society of Chemistry</text>
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                <text>DOI: 10.1039/C5DT01321F</text>
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                <text>&lt;strong&gt;The crystal structure of a naturally occurring &amp;gamma;-lactone glucoside (C11H16O8.H2O) from Helleborus foetida L.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mariezcurrena, R.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rasmussen, S. E.&lt;/strong&gt;</text>
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                <text>Acta Crystallographica : Section B v. 29, n&amp;ordm;. 5, 1973. -- p. 1030-1035</text>
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            <elementTextContainer>
              <elementText elementTextId="387657">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The interpretation of the gas-phase and matrix-isolation vibrational spectra of the water dimer and monomer had led to contradictory conclusions as to the effect of dimerization of the OH-stretching fundamentals. Ab initio MPn/6-311+G(2d, 2p) and MPn/+VPs(2d)s calculations (with n=2&amp;ndash;4) have been performed on the water dimer to determine accurately that dimerization shift. In order to assess the quality of the computational results, frequency shifts were calculated at the same level also for several other binary complexes involving hydrogen bonds, and for which there are not large discrepancies between the gas-phase and solid-matrix data. Full geometry optimization of the complexes was performed. Analytically (SCF, MP2) or numerically (MP3, MP4) determined frequencies at the optimized geometries were employed to obtain the frequency shifts in question. In all cases a satisfactory agreement between the theoretical and solid-matrix data was found. SCF calculations underestimate and MP2 calculations overestimate the shifts in all cases. However, in only one of the complexes studied, the N2&amp;middot;HF dimer, were the MP2 results far off the experimental ones. Both in this case and for the water dimer it was necessary to use a higher order of perturbation theory (MP3, MP4) to calculate the correlation correction, in order to obtain satisfactory convergence of the frequency shifts. In conclusion, our theoretical calculations indicate that the gas-phase experimental data on the dimerization shift of the OH fundamentals of the water dimer need to be reinterpreted. As a side result, we suggest a reassignment of the &amp;nu;3 vibrational transition of the water monomer, performed in the recent experiments of water trapped in a Ne solid matrix.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;Pantoea ananatis is a gram-negative bacterium and the primary causal agent of center rot of onions in Georgia. Previous genomic studies identified two virulence gene clusters, HiVir and alt, associated with center rot. The HiVir gene cluster is required to induce necrosis on onion tissues via synthesis of pantaphos, (2-hydroxy[phosphonomethyl) maleate), a phosphonate phytotoxin. The alt gene cluster aids in tolerance&lt;br /&gt;to thiosulfinates generated during onion tissue damage. Whole genome sequencing of other Pantoea species suggests that these gene clusters are present outside of P. ananatis. To assess the distribution of these gene clusters, two PCR primer sets were designed to detect the presence of HiVir and alt. Two hundred fifty-two strains of Pantoea spp. were phenotyped using the red onion scale necrosis (RSN) assay and were genotyped using PCR for the presence of these virulence genes. A diverse panel of strains from three distinct culture collections comprised of 24 Pantoea species, 41 isolation sources, and 23 countries, collected from 1946&amp;ndash;2019, was tested. There is a&lt;br /&gt;significant association between the alt PCR assay and Pantoea strains recovered from symptomatic onion (P &amp;lt; 0.001). There is also a significant association of a positive HiVir PCR and RSN assay among P. ananatis strains but not among Pantoea spp.,&lt;br /&gt;congeners. This may indicate a divergent HiVir cluster or different pathogenicity and virulence mechanisms. Last, we describe natural alt positive [RSN C /HiVir C /alt C ]&lt;br /&gt;P. ananatis strains, which cause extensive bulb necrosis in a neck-to-bulb infection assay compared to alt negative [RSN C /HiVir C /alt&lt;/p&gt;</text>
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                <text>A sticking probability model based on the average cluster lifetime is employed for deducing a kernel capable to describe the kinetics of computer simulated irreversible aggregation processes in two dimensions. The deduced kernel describes not only the time evolution of the cluster size distribution for di�usion limited aggregation (DLCA) and reaction limited aggregation (RLCA) but also for the entire transition region between both regimes. The model predicts a crossover to di�usion limited cluster aggre- gation for all sticking probabilities at long aggregation times. The time needed for reaching the DLCA limit increases for decreasing sticking probability.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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                <text>&lt;strong&gt;The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis&lt;/strong&gt;</text>
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                <text>&lt;p&gt;BACKGROUND: Scavenger Receptors (SRs) from the host's innate immune system are known to bind multiple ligands to promote the removal of non-self or altered-self targets. CD5 and CD6 are two highly homologous class I SRs mainly expressed on all T cells and the B1a cell subset, and involved in the fine tuning of activation and differentiation signals delivered by the antigen-specific receptors (TCR and BCR, respectively), to which they physically associate. Additionally, CD5 and CD6 have been shown to interact with and sense the presence of conserved pathogen-associated structures from bacteria, fungi and/or viruses.METHODOLOGY/PRINCIPAL FINDINGS: We report herein the interaction of CD5 and CD6 lymphocyte surface receptors with Echinococcus granulosus sensu lato (s.l.). Binding studies show that both soluble and membrane-bound forms of CD5 and CD6 bind to intact viable protoscoleces from E. granulosus s.l. through recognition of metaperiodate-resistant tegumental components. Proteomic analyses allowed identification of thioredoxin peroxidase for CD5, and peptidyl-prolyl cis-trans isomerase (cyclophilin) and endophilin B1 (antigen P-29) for CD6, as their potential interactors. Further in vitro assays demonstrate that membrane-bound or soluble CD5 and CD6 forms differentially modulate the pro- and anti-inflammatory cytokine release induced following peritoneal cells exposure to E. granulosus s.l. tegumental components. Importantly, prophylactic infusion of soluble CD5 or CD6 significantly ameliorated the infection outcome in the mouse model of secondary cystic echinococcosis. CONCLUSIONS/SIGNIFICANCE: Taken together, the results expand the pathogen binding properties of CD5 and CD6 and provide novel evidence for their therapeutic potential in human cystic echinococcosis&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Mourglia Ettlin, Gustavo Daniel.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Miles, Sebasti&amp;aacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Armiger-Borr&amp;aacute;s, N.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Cucher, M.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Lozano, F.&lt;/strong&gt;</text>
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                <text>Plos Neglected Tropical Diseases v. 12, no. 11, 2018. -- 24p.--e0006891</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;The Effect of A Hexanoic Acid Linker Insertion on the Pharmacokinetics and Tumor Targeting Properties of the Melanoma Imaging Agent 99mTc-HYNIC-cycMSH&lt;/strong&gt;</text>
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                <text>Background: Lactam cyclized alpha-melanocyte stimulating hormone (&amp;alpha;-MSH) analogues exhibit high stability and affinity for the MC1-R receptors over expressed in melanoma cells. Recently, we reported a novel &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; analogue with the HYNIC chelator directly attached to the lactam cyclized ring. Objective: In this study we proposed the introduction of a 6-aminohexanoic acid (Ahx) linker between the HYNIC chelator and lactam cyclized peptide cycMSH4-13 to reduce steric hindrance and improve the melanoma targeting and imaging proprieties of the radiolabeled peptide. Method: HYNIC-Ahx-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; peptide was synthesized on an automated peptide synthesizer and displayed an IC50 of 0.3 nM using B16/F1 cells. The 99mTc/tricine radiolabeled peptide was examined for radiochemical purity, stability and cell binding. In vivo, biodistribution and planar gamma imaging studies were performed in B16/F1 melanoma tumor bearing C57BK mice. Results: &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-Ahx-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; was obtained with a radiochemical purity &amp;gt;95%, was stable up to 24 h at room temperature and exhibited high binding and rapid internalization in B16/F1 cells. In vivo biodistribution studies showed a tumor uptake of 4.92 &amp;plusmn; 0.92 % ID/g and 2.78 &amp;plusmn; 1.48 % ID/g at 2 h and 4 h post injection, respectively. Whole-body clearance was rapid through urinary excretion. The melanoma tumors were clearly visualized by planar gamma imaging. Conclusion: &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-Ahx-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; was shown radiochemically stability and exhibited rapid and selective uptake in melanoma cells and tumors. Imaging studies yielded promising preclinical results, warranting further evaluation of &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-cycMSH analogs as melanoma specific imaging agent</text>
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&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>During malolactic fermentation (MLF), lactic acid bacteria influence aroma and flavor of wines by the production of volatile metabolites and the modification of aroma compounds derived from grapes and yeasts. In an effort to isolate these bacteria properties as advantages for winemaking, this study aimed to assess the relative contribution of two aspects: the effects of lactic acid bacteria activity on the volatiles compounds in Tannat wines and the consequences of aging in bottle on aroma compounds produced during MLF. To our knowledge, this is the first report related to the effect of wine aging in bottle on the aroma chemical compounds produced by MLF. Solid phase extraction complemented with chromatographic techniques was used to study the wine aroma compounds. A sensory evaluation of the wines was also performed through descriptive methods. We demonstrated modifications in the concentration of acetates, ethyl esters, and other secondary metabolites during MLF. Major sensorial differences between wines that had undergone MLF were also noted. In addition, some modifications detected in the composition of Tannat wines as a consequence of the aging in bottle contributed to the change in differences between wines with and without MLF and furthermore between strains. These changes probably influence its fruity character.</text>
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                <text>&lt;strong&gt;Versini, Giuseppe&lt;/strong&gt;</text>
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                <text>Journal of Agricultural and Food Chemistry |g v. 57, no.14, 2009. -- p.6271-6278</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;The effect of cation modifier on improving the luminescent properties of borate glasses doped with Yb3 + and Er3 +&lt;/strong&gt;</text>
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                <text>In this work we present the preparation and characterization of new fluoroborate glasses doped with Yb3 + and Er3 + and modified by Ca, Sr and Ba oxides. Glasses with compositions (100-x-y) (MO &amp;sdot; 2B2O3) + x NaF + y (YbF3:ErF3) (% in mol), where M is Sr, Ba, Ca, x = 10&amp;ndash;30% and y = 0, 1 or 5% were prepared by the melt/quenching technique. Glass forming ability and stability were studied by thermal analysis and it is shown that calcium samples presented the highest stability. The nature of the modifier cation has also shown a direct influence on the absolute and relative intensities of the rare earth ions transitions in the visible and near-infrared regions. Though the calcium samples present lower absorption intensities, they display the best up- and down-conversion efficiencies. There are evidences that the incorporation of the fluoride compound leads to a fluorine rich environment on the first coordination sphere of the RE, decreasing the probability of OH&amp;ndash; groups &amp;ndash; well known quenchers of RE emissions. Though preliminary, the results in this study can become of relevance for the field of solar cell technology improvement via betterment of solar light harvesting in the infrared and ultraviolet regions.</text>
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                <text>Journal of Non-Crystalline Solids v. 483, 2018. -- p. 79-85</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>DOI: 10.1016/j.jnoncrysol.2018.01.002</text>
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        <name>Borato</name>
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        <name>Propiedades luminiscentes</name>
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        <name>Vidrios dopantes</name>
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