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                <text>&lt;strong&gt;Crystal structure and Hirshfeld surface analysis of lapachol acetate 80 years after its first synthesis&lt;/strong&gt;</text>
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                <text>ESTRUCTURA CRISTALINA</text>
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                <text>ANALISIS DE HIRSHFELD</text>
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                <text>Lapachol acetate [systematic name: 3-(3-methyl&amp;shy;but-2-en&amp;shy;yl)-1,4-dioxonaph&amp;shy;thalen-2-yl acetate], C17H16O4, was prepared using a modified high-yield procedure and its crystal structure is reported for the first time 80 years after its first synthesis. The full spectroscopic characterization of the mol&amp;shy;ecule is reported. The mol&amp;shy;ecular conformation shows little difference with other lapachol derivatives and lapachol itself. The packing is directed by inter&amp;shy;molecular &amp;pi;&amp;ndash;&amp;pi; and C&amp;mdash;H...O inter&amp;shy;actions, as described by Hirshfeld surface analysis. The former inter&amp;shy;actions make the largest contributions to the total packing energy in a ratio of 2:1 with respect to the latter.</text>
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                <text>&lt;strong&gt;Mart&amp;iacute;nez-Cabrera, Miguel A.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mac&amp;iacute;as, Mario A.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ferreira, Francisco&lt;/strong&gt;</text>
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                <text>&lt;span style="text-decoration: underline;"&gt;&lt;/span&gt;Acta Crystallographica E v.75, 2019. -- p. 1362&amp;ndash;1366</text>
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                <text>International Union of Crystallography</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>DOI:10.1107/S2056989019011393</text>
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        <name>Acetato de Lapchatol</name>
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                <text>&lt;strong&gt;GC&amp;ndash;MS and LC&amp;ndash;MS/MS workflows for the identification and quantitation of pyrrolizidine alkaloids in plant extracts, a case study: Echium plantagineum&lt;br /&gt;&lt;/strong&gt;</text>
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                <text>Workflows based on gas and liquid chromatography coupled to mass spectrometry for the identification of toxic pyrrolizidine alkaloids present in plants were developed and applied to Echium plantagineum L., Boraginaceae, extracts. GC&amp;ndash;MS based determinations need reduction and derivatization steps prior to MS analysis, which is performed using a Full Scan and Single Ion Monitoring sequence for screening, identification and quantification purposes. The LC&amp;ndash;(ESI)&amp;ndash;MS/MS determination was performed directly from the extract without derivatization. Acetyl lycopsamine, echimidine, echimidine N-oxide, echiumine, echiumine N-oxide, lycopsamine, lycopsamine N-oxide, 7,9-ditigloylretronecine N-oxide and a not reported PA of m/z 466, were identified and quantified in E. plantagineum extracts, through three operating modes of LC-QTRAP: precursor ion scan, enhanced product ion scan and multiple reaction monitoring. Precursor ion scan detects all the ions that give rise to a daughter ion at m/z 120, the presence of the parent pyrrolizidine alkaloid is confirmed through its MS2 spectrum (enhanced product ion) and quantified by multiple reaction monitoring. These workflows are general approaches to study chemical families using GC/LC-MS. For extracts suspicious of containing pyrrolizidine alkaloids, they are suitable tools for the quality and safety control of food, feed as well as phytotherapeutics.</text>
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                <text>Revista Brasileira de Farmacognosia |g v. 29, no. 4, 2019. -- p. 500-503</text>
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                <text>Sociedade Brasileira de Farmacognosia</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Design of a white-light emitting material based on a mixed-lanthanide metal organic framework&lt;/strong&gt;</text>
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                <text>The design of white-light emitting materials for solid-state lighting technology is governed by the combination of independent red, green and blue emitting centers. Many mixed-lanthanide single phase white-light source materials have been produced so far by a careful trial and error combination of lanthanide ions during the synthetic procedure. In this work we propose a simple and efficient method for the direct preparation of the desired material with the optimal combination of metal ions, avoiding the trial and error multiple synthetic approach. In the proposed strategy, the emission profiles of the isostructural complexes of each lanthanide ion for a chosen excitation wavelength are compared relative to their ion density and the necessary final composition of the material is calculated in order to obtain the white-light CIE coordinates. Using this method, we prepared a white-light emitting material which is a metal-organic framework built from oxydiacetate ligand, lanthanide ions (Eu, Tb and Dy emitting red, green and blue respectively) and zinc (a closed shell metal ion that has proven to be ideal for optical applications). The compound [Dy1.60Eu0.38Tb0.02Zn3(oda)6(H2O)6]&amp;middot;12H2O was prepared and fully characterized by single crystal x-ray diffraction, its optical properties were also measured. The proposed rational mixing of lanthanide ions could be useful for the preparation of white-light source materials in analogous systems, provided the single-lanthanide compounds are isostructural along the series and no optical interaction is operative among ions.</text>
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                <text>&lt;strong&gt;Igoa, Fernando&lt;/strong&gt;</text>
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                <text>Journal of Solid State Chemistry v. 279, 2019. --6p. --e120925</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The title complex, {[Ni(hab)]K[(hab)Ni]}&amp;middot;SCN (H 2 hab is bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminobenzene) crystallizes in the Monoclinic space group P2 1 /c with unit cell dimensions a = 11.5891 (13) &amp;Aring;, b = 17.307 (2) &amp;Aring;, c = 19.781 (2) &amp;Aring;,&amp;beta; = 92.368 (10)&amp;deg;, V = 3964.2 (8) &amp;Aring; 3 , Z = 4, R 1 = 0.106 and wR 2 = 0.305. The Ni II cation is in a N 2 O 2 inner and has a distorted square-planar coordination environment. The Ni II cation is linked by two imino nitrogen atoms and two bridged phenolate oxygen atoms. The potassium cation is octacoordinated in O 8 donor site and linked by four bridged phenolate oxygen atoms and four methoxy oxygen atoms. In the crystal, the {[Ni(hab)]K[(hab)Ni]} + cations form layers parallel to the ab plane. The SCN-anions are located in the interlayer space and connect the layers via C-H&amp;hellip;N and C-H&amp;hellip;S hydrogen bonds, forming three dimensional network.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The crystal structure of the title compound, [Ni3(C8H4O4)3(C3H7NO)4], is a two-dimensional coordination network formed by trinuclear linear Ni3(tp)3(DMF)4 units (tp = terephthalate = benzene-1,4-di&amp;shy;carboxyl&amp;shy;ate and DMF = di&amp;shy;methyl&amp;shy;formamide) displaying a characteristic coordination mode of acetate groups in polynuclear metal&amp;ndash;organic compounds. Individual trinuclear units are connected through tp anions in a triangular network that forms layers. One of the DMF ligands points outwards and provides inter&amp;shy;actions with equivalent planes above and below, leaving the second ligand in a structural void much larger than the DMF mol&amp;shy;ecule, which shows positional disorder. Parallel planes are connected mainly through weak C&amp;mdash;H⋯O, H⋯H and H⋯C inter&amp;shy;actions between DMF mol&amp;shy;ecules, as shown by Hirshfeld surface analysis.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Development of new antimicrobial agents, capable of combating resistant and multidrug-resistant fungal and bacterial clinical strains, is necessary. This study presents the synthesis and antimicrobial screening of 42 2-substituted-1,4-benzenediols, being 10 novel compounds. In total, 23 compounds showed activity against fungi and/or bacteria. Benzenediol compounds 2, 5, 6, 8, 11, and 12 demonstrated broad spectrum antimicrobial actions, including resistant and multidrug-resistant species of dermatophytes (Trichophyton mentagrophytes), Candida spp. and the ESKAPE panel of bacteria. Minimum inhibitory concentrations of these compounds for fungi and bacterial strains ranged from 25 to 50 &amp;micro;g/ml and 8&amp;ndash;128 &amp;micro;g/ml, respectively. The antifungal mechanism of action is related to the fungal cell wall of dermatophytes and membrane disruption to dermatophytes and yeasts, in the presence of compound 8. Specific structural changes, such as widespread thinning along the hyphae and yeast lysis, were observed by scanning electron microscopy. The effects of compound 8 on cell viability are dose-dependent; however they did not cause genotoxicity and mutagenicity in human leukocyte cells nor haemolysis. Moreover, the compounds were identified as nonirritant by the ex-vivo Hen&amp;rsquo;s egg test-chorioallantoic membrane (HET-CAM). The furan-1,4-benzenediol compound 5 showed in vivo efficacy to combat S. aureus infection using embryonated chicken eggs. Therefore, the compounds 8, and 5 are promising as hits for the development of new antimicrobial drugs with reduced toxicity.</text>
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                <text> Avances en Ciencias e Ingenieria  v. 10, no. 3, 2019. -- p. 33-40</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;New hexanuclear FeIII clusters with the gem-diol hydrated form of di(2-pyridyl)ketone and carboxylato ligands :&amp;nbsp; Crystal structures and magnetic properties&lt;/strong&gt;</text>
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                <text>The hexanuclear compounds [Fe6O2Cl2{(py)2CO2}2(pyOH)2(pyCOO)2(ButCOO)6] (1) and [Fe6O2{(py)2CO2}2(pyCOO)4(ButCOO)6] (2) were obtained by condensation of the trinuclear &amp;mu;3-oxo-centered iron(III) pivalate [Fe3O(ButCOO)6(H2O)3]+ in the presence of di(2-pyridyl)ketone [(py)2CO] in MeCN at ambient temperature. Both complexes contain an analogous core which can be described as two {Fe3O}7+ units joined by gem-diolato (py)2CO22&amp;minus; bridges. Variable-temperature magnetic susceptibility measurements in polycrystalline samples of 1 and 2 reveal strong antiferromagnetic couplings between the iron(III) ions leading to S = 0 ground states.</text>
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                <text>&lt;a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=2d464bf82e7bcaa15f4b0fbb018032c3001b5ddbb2f3240974290c1101a83a48fdf510e499125c718077733be2e225e06e5bc041529e5912a19205af86801bf0&amp;amp;formato=pdf&amp;amp;convocatoria=21" target="_self"&gt;&lt;strong&gt;Arizaga, Livia.&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Polyhedron v. 174, 2019. --10p.--e114165</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The parallel segmented flow (PSF) chromatography column was applied for the first time to trace residue analyses with mass spectral detection. Three problematic pesticides, notorious for poor peak shape and ionization issues were selected to illustrate the advantages and disadvantages of utilizing the PSF column as an alternative front-end separation interface for LC-MS approaches. Assessment of performance for each pesticide was based on a spiked lemon matrix prepared via a QuEChERS (quick, easy, cheap, rugged and safe) sample preparation approach. Comparisons were made between assays conducted using a conventional column and a PSF column (operated with a 40% segmentation ratio), each packed with identical stationary phases and of the same column format. Both columns were connected to the MS detector using the exact same connective tubing and electrospray (ESI) conditions. The primary advantage of the PSF column was that it enabled an increase in throughput by at least 2.5 times compared to the conventional HPLC column. At the same time, the volumetric flow to the MS was exactly the same for both the PSF column and the conventional column. Effectively there was no difference in the sensitivity provided by peak areas between the PSF and conventional columns: peak area LOQ values were comparable, 4&amp;ndash;9 &amp;mu;g/kg for the PSF and 4&amp;ndash;8 &amp;mu;g/kg for the conventional column. This is a vital requirement for food control methods to secure absence at default maximum residue limit (MRL) of 10 &amp;mu;g/kg (10 ppb) level. Since the efficiency of the PSF was superior to that of the conventional column, the peak width of eluting components was reduced by as much as 70% in the former compared to the peak widths on the latter. Hence, the PSF column provides greater peak capacity and this will enable faster analysis of complex samples.</text>
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                <text>&lt;strong&gt;Soliven, Arianne&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rodr&amp;iacute;guez, Cecilia.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Shalliker, R. Andrew&lt;/strong&gt;</text>
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                <text>&lt;a title="Curr&amp;iacute;culum" href="https://www.google.com/url?sa=t&amp;amp;rct=j&amp;amp;q=&amp;amp;esrc=s&amp;amp;source=web&amp;amp;cd=1&amp;amp;cad=rja&amp;amp;uact=8&amp;amp;ved=2ahUKEwjFsIWj5r_mAhVkIbkGHf6iB7QQFjAAegQIBRAH&amp;amp;url=https%3A%2F%2Fexportcvuy.anii.org.uy%2FCvEstatico%2F%3FurlId%3Dfda2ddd3225e35b6cd0dd11333996b08c4f2ec35ccdbe92a4a51420f1bc7853e8c31c9c047392931df7517b95a6a8bc0513e278125b0cdd382223a0af2e3d381%26formato%3Dpdf%26convocatoria%3D21&amp;amp;usg=AOvVaw27THRXuO9wnELzxGIHdvMy" target="_blank"&gt;&lt;strong&gt;P&amp;eacute;rez Parada, Andr&amp;eacute;s&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Microchemical Journal v. 148, 2019. -- p. 177-184</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                  <text>Historia de la Facultad de Química desde 1908 hasta la fecha y diversos materiales de carácter histórico.</text>
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                <text>&lt;strong&gt;Kurylenko, Constantin&lt;/strong&gt;</text>
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                <text>PR : Organo Oficial de la Asociaci&amp;oacute;n de Estudiantes de Qu&amp;iacute;mica (Uruguay) v.2 no 5-6, p c107-c120</text>
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                <text>1952</text>
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              <elementText elementTextId="528508">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Biotransformaci&amp;oacute;n del Glicerol, obtenido en la producci&amp;ograve;n de biodi&amp;eacute;sel en productos de mayor valor agregado&lt;/strong&gt;</text>
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                <text>La producci&amp;oacute;n de biodi&amp;eacute;sel mediante la reacci&amp;oacute;n de transesterificaci&amp;oacute;n (&amp;uacute;nico proceso tecnol&amp;oacute;gicamente maduro a la fecha para ese prop&amp;oacute;sito) genera simult&amp;aacute;neamente como subproducto glicerol en relaci&amp;oacute;n aproximadamente 9:1 en masa. La evoluci&amp;oacute;n positiva que en los &amp;uacute;ltimos a&amp;ntilde;os ha presentado la producci&amp;oacute;n de este biocombustible a nivel global ha desencadenado la introducci&amp;oacute;n de vol&amp;uacute;menes inmanejables para el mercado del glicerol, presionando fuertemente a la baja su precio. Este hecho -de no encontrarse una soluci&amp;oacute;namenaza impactar en la sustentabilidad ambiental y econ&amp;oacute;mica del biodi&amp;eacute;sel. La b&amp;uacute;squeda de alternativas a esta sobreproducci&amp;oacute;n de glicerol ha sido un desaf&amp;iacute;o atendido por la comunidad cient&amp;iacute;fica internacional desarroll&amp;aacute;ndose m&amp;uacute;ltiples estrategias (desde la b&amp;uacute;squeda de nuevas aplicaciones que permitan su uso directo, el uso enproductos masivos que lo demanden como insumo, as&amp;iacute; como la b&amp;uacute;squeda de s&amp;iacute;ntesis de productos que impliquen agregado de valor a este co-producto). El presente trabajo se inscribe dentro de esta &amp;uacute;ltima alternativa proponiendo la valorizaci&amp;oacute;n del glicerol a trav&amp;eacute;s de su biotransformaci&amp;oacute;n en 1,2-propanodiol enantiom&amp;eacute;ricamente puro y su posterior derivatizaci&amp;oacute;n obteni&amp;eacute;ndose sintones quirales con aplicaci&amp;oacute;n en qu&amp;iacute;mica fina. Recurriendo a ingenier&amp;iacute;a metab&amp;oacute;lica en E. coli se handise&amp;ntilde;ado, construido y evaluado un conjunto de biocatalizadores con ese objetivo. A partir de la expresi&amp;oacute;n de la metilglioxal sintasa (mgs) de E. coli,una metilglioxal reductasa (Gre2p) y una aldeh&amp;iacute;do reductasa(Ypr1p ) ambas de S. cerevisiae,se ha logrado obtener (R)-1,2-propanodiol enantiom&amp;eacute;ricamente puro (con un e.e. &amp;gt; 99 %, en concentraci&amp;oacute;n de 0,45 g/L)a partir de glicerol. Esteproducto, adem&amp;aacute;s de constituir una alternativa de valorizaci&amp;oacute;n en s&amp;iacute; mismo es punto de partida para otros compuestos de elevado valor agregado,entre ellos, en el presente trabajo se ha logrado la s&amp;iacute;ntesis qu&amp;iacute;mica del (R)-2-metoxi metoxi-1-propanoly de (R)- propilencarbonato</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Freshwater harmful algal blooms produce a broad array of bioactive compounds, with variable polarity. Acute exposure to cyanotoxins can impact the liver, nervous system, gastrointestinal tract, skin, and immune function. Increasing evidence suggests chronic effects from low-level exposures of cyanotoxins and other associated bioactive metabolites of cyanobacterial origin. These sundry compounds persist in drinking and recreational waters and challenge resource managers in detection and removal. A systematic approach to assess the developmental toxicity of cyanobacterial metabolite standards was employed utilizing a robust and high throughput developmental Danio rerio embryo platform that incorporated a neurobehavioral endpoint, photomotor response. Subsequently, we applied the platform to cyanobacterial bloom surface water samples taken from temperate recreational beaches and tropical lake subsistence drinking water sources as a model approach. Dechorionated Danio rerio embryos were statically immersed beginning at four to six hours post fertilization at environmentally relevant concentrations, and then assessed at 24 h and 5 days for morbidity, morphological changes, and photomotor response. At least one assessed endpoint deviated significantly for exposed embryos for 22 out of 25 metabolites examined. Notably, the alkaloid lyngbyatoxin&amp;ndash;a resulted in profound, dose-dependent morbidity and mortality beginning at 5 &amp;mu;g/L. In addition, hydrophobic components of extracts from beach monitoring resulted in potent morbidity and mortality despite only trace cyanotoxins detected. The hydrophilic extracts with several order of magnitude higher concentrations of microcystins resulted in no morbidity or mortality. Developmental photomotor response was consistently altered in environmental bloom samples, independent of the presence or concentration of toxins detected in extracts. While limited with respect to more polar compounds, this novel screening approach complements specific fingerprinting of acutely toxic metabolites with robust assessment of developmental toxicity, critical for chronic exposure scenarios.</text>
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                <text>Science of the Total Environment v. 697, 2019. -- p. 1-13.--e134210</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1016/j.scitotenv.2019.134210</text>
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                <text>&lt;strong&gt;A novel nitroalkene-L-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in apoE knockout mice&lt;/strong&gt;</text>
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                <text>BACKGROUND AND PURPOSE: Atherosclerosis is characterized by chronic low-grade inflammation with concomitant lipid accumulation in the arterial wall. Anti-inflammatory and anti-atherogenic properties have been described for a novel class of endogenous nitroalkenes (nitrated-unsaturated fatty acids), formed during inflammation and digestion/absorption processes. The lipid-associated antioxidant &amp;alpha;-tocopherol is transported systemically by LDL particles including to the atheroma lesions. To capitalize on the overlapping and complementary salutary properties of endogenous nitroalkenes and &amp;alpha;-tocopherol, we designed and synthesized a novel nitroalkene-&amp;alpha;-tocopherol analogue (NATOH) to address chronic inflammation and atherosclerosis, particularly at the lesion sites. EXPERIMENTAL APPROACH: We synthesized NATOH, determined its electrophilicity and antioxidant capacity and studied its effects over pro-inflammatory and cytoprotective pathways in macrophages in vitro. Moreover, we demonstrated its incorporation into lipoproteins and tissue both in vitro and in vivo, and determined its effect on atherosclerosis and inflammatory responses in vivo using the Apo E knockout mice model. KEY RESULTS: NATOH exhibited similar antioxidant capacity to &amp;alpha;-tocopherol and, due to the presence of the nitroalkenyl group, like endogenous nitroalkenes, it exerted electrophilic reactivity. NATOH was incorporated in vivo into the VLDL/LDL lipoproteins particles to reach the atheroma lesions. Furthermore, oral administration of NATOH down-regulated NF-&amp;kappa;B-dependent expression of pro-inflammatory markers (including IL-1&amp;beta; and adhesion molecules) and ameliorated atherosclerosis in Apo E knockout mice. CONCLUSIONS AND IMPLICATIONS: In toto, the data demonstrate a novel pharmacological strategy for the prevention of atherosclerosis based on a creative, natural and safe drug delivery system of a non-conventional anti-inflammatory compound (NATOH) with significant potential for clinical application.</text>
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                <text>&lt;strong&gt;Rodr&amp;iacute;guez Duarte, Jorge.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Galliussi, Germ&amp;aacute;n.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Dapueto, Rosina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rosello, Jessica&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Malacrida, Leonel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Kamaid, Andr&amp;eacute;s&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Schopfer, Francisco J.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Escande, Carlos&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Batthy&amp;aacute;ny Dighiero, Carlos Ignacio.&lt;/strong&gt;</text>
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                <text>British Journal of Pharmacology&amp;nbsp; v. 176, no. 6, 2019. --p. 757-772</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Plant defensins comprise a large family of antimicrobial peptides (AMP) with a wide range of biological functions. They are cysteine-rich molecules, highly sequence diverse but with a conserved and stable structure. In this work, a defensin gene (EcgDf1) was isolated from Erythrina crista-galli, a legume tree native from South America. The predicted peptide presents eight cysteines, with a &amp;gamma;-core motif GXCX3-9C and six cysteines distributed like the typical defensin &amp;alpha;&amp;beta; motif. The mature EcgDf1 coding sequence was heterologously expressed in Escherichia coli strains and purified by affinity chromatography. Possible dimer and oligomers of EcgDf1 were visible in SDS electrophoresis. Moreover, its 3D structure, determined by homology modeling, docking, and molecular dynamics simulations, was found to be compatible with the formation of homodimers between the &amp;beta;3 and &amp;beta;1-loop-&amp;alpha;1, leaving the &amp;beta;2-loop-&amp;beta;3 free to interact with lipid membranes. The purified recombinant peptide inhibited the growth of several critical plant and human pathogens, like the opportunistic fungi Candida albicans and Aspergillus niger and the plant pathogens Clavibacter michiganensis ssp. michiganensis, Penicillium expansum, Botrytis cinerea, and Alternaria alternata. EcgDf1 is a promising candidate for the development of antimicrobial products for use in agriculture and medicine.</text>
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                <text>&lt;strong&gt;Rodr&amp;iacute;guez Decuadro, Susana Beatriz.&lt;/strong&gt;</text>
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                <text>Planta v. 250, no. 5, 2019.--p. 1757-1772</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1007/s00425-019-03260-w</text>
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                <text>&lt;strong&gt;Impact of Holder pasteurization on immunological properties of human breast milk over the first year of lactation&lt;/strong&gt;</text>
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                <text>PAUSTERIZACION</text>
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                <text>Background The timing of milk donations to human milk banks ranges from a few days to more than 1 year after delivery, and the Holder method is used for pasteurization. We evaluated the effect of temporal variation and thermal treatment on the immunological properties of milk. Methods We analyzed 73 milk samples, raw and after pasteurization, donated at different lactation stages. We studied antibodies, lysozyme, cytokines, soluble receptors, and factors with impact on barrier function. We also evaluated in vitro the capacity of milk to modulate nuclear factor-&amp;kappa;B (NF-&amp;kappa;B) signaling in an HT-29 epithelial cell line stimulated with tumor necrosis factor-&amp;alpha; (TNF-&amp;alpha;). Results With few exceptions, immune components exhibited their highest levels in colostrum, and were stable in the various stages of mature milk. Pasteurization altered the immunological composition of milk, and very drastically for some components. Raw milk of the first year reduced NF-&amp;kappa;B activation in HT-29 cells treated with TNF-&amp;alpha; to approximately the same extent, and Holder pasteurization significantly affected this capacity. Conclusions Overall, the present work reports that mature donated milk is equally valuable over the first year of lactation, but warns about drastic losses of anti-inflammatory properties during Holder pasteurization that could be critical for the health of preterm infants.</text>
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                <text>&lt;strong&gt;Rodr&amp;iacute;guez Camejo, Claudio&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Puyol, Arturo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;S&amp;oacute;&amp;ntilde;ora, Cecilia.&lt;/strong&gt;</text>
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                <text>Pediatric Research v. 87, 2020.-- p. 32-41</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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              <elementText elementTextId="524384">
                <text>&lt;strong&gt;New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents&lt;/strong&gt;</text>
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          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="524385">
                <text>ENFERMEDAD DE CHAGAS</text>
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              <elementText elementTextId="524386">
                <text>TRIPANOSOMIASIS</text>
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              <elementText elementTextId="524387">
                <text>ANTITRIPANOSOMAS</text>
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              <elementText elementTextId="524388">
                <text>BIBLIOGRAFIA NACIONAL QUIMIC</text>
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              <elementText elementTextId="524389">
                <text>2019</text>
              </elementText>
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          </element>
          <element elementId="87">
            <name>Abstract</name>
            <description>A summary of the resource.</description>
            <elementTextContainer>
              <elementText elementTextId="524390">
                <text>In the search for a more effective chemotherapy for the treatment of Chagas&amp;rsquo; disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic compounds may be a promising strategy. In this work, eight new heterobimetallic compounds are described including four 5-nitrofuryl containing thiosemicarbazones as bioactive ligands (HL1&amp;ndash;HL4) and dppf = 1,1&amp;prime;-bis(diphenylphosphino) ferrocene as an organometallic co-ligand. Complexes of the formula [MII(L)(dppf)](PF6) with M = Pd or Pt were synthesized and fully characterized in the solid state and in solution, including the determination of the molecular structure of four of them by single crystal X-ray diffraction methods. Most compounds showed activity in the low micromolar or submicromolar range against both parasites, with the platinum compounds being more active than the palladium analogues. Activity was significantly increased by generation of the M-dppf compounds (3&amp;ndash;24 fold increase with respect to free ligands HL for T. cruzi and up to 99 fold increase with respect to HL for T. brucei). The inclusion of the organometallic co-ligand also led to lower toxicity in mammalian cells and higher selectivity towards both parasites when compared to the free HL compounds. The complexes interact with DNA and affect the redox metabolism of the parasites. Furthermore, the most active and selective compound of the new series showed no in vivo toxicity in zebrafish embryos.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="524391">
                <text>&lt;strong&gt;Rodr&amp;iacute;guez Arce, Esteban&lt;/strong&gt;</text>
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              <elementText elementTextId="524392">
                <text>&lt;strong&gt;Putzu, Eugenia&lt;/strong&gt;</text>
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              <elementText elementTextId="524393">
                <text>&lt;strong&gt;Lapier, Michel&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="524394">
                <text>&lt;strong&gt;Maya, Juan Diego&lt;/strong&gt;</text>
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              <elementText elementTextId="524395">
                <text>&lt;strong&gt;Olea-Azar, Claudio.&lt;/strong&gt;</text>
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              <elementText elementTextId="524396">
                <text>&lt;strong&gt;Echeverr&amp;iacute;a, Gustavo A&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="524397">
                <text>&lt;strong&gt;Piro, Oscar E.&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="524398">
                <text>&lt;strong&gt;Medeiros, Andrea&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="524399">
                <text>&lt;strong&gt;Sardi, Florencia&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="524400">
                <text>&lt;strong&gt;Comini, Marcelo&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="524401">
                <text>&lt;strong&gt;Risi, Gast&amp;oacute;n.&lt;/strong&gt;</text>
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              <elementText elementTextId="524402">
                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8b2cacb0aafc512133624fa7b9bf174c" target="_self"&gt;&lt;strong&gt;Salinas, Gustavo.&lt;/strong&gt;&lt;/a&gt;</text>
              </elementText>
              <elementText elementTextId="524403">
                <text>&lt;strong&gt;Correia, Isabel&lt;/strong&gt;</text>
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              <elementText elementTextId="524404">
                <text>&lt;strong&gt;Costa Pessoa, Jo&amp;atilde;o&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="524405">
                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b2795d82d8f9cb610b167b6577f861a5" target="_self"&gt;&lt;strong&gt;Otero Zubiaurre, Ana Luc&amp;iacute;a&lt;/strong&gt;&lt;/a&gt;</text>
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              <elementText elementTextId="524406">
                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_self"&gt;&lt;strong&gt;Gambino, Dinorah.&lt;/strong&gt;&lt;/a&gt;</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="524407">
                <text>Dalton Transactions v. 48, no. 22, 2019.--p. 7644-7658</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="524408">
                <text>Royal Society of Chemistry</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="524409">
                <text>2019</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="524410">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="524411">
                <text>PDF</text>
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            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="524412">
                <text>Ingl&amp;eacute;s</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="524413">
                <text>Art&amp;iacute;culo</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="524414">
                <text>DOI: 10.1039/C9DT01317B</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="61">
        <name>Antitripanosomas</name>
      </tag>
      <tag tagId="87">
        <name>Enfermedad de chagas</name>
      </tag>
      <tag tagId="275">
        <name>Tripanosomiasis</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
