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                <text>Two iron(II)-rhenium(IV) compounds of general formula [FeII(dmf)6][ReIVX6] [X = Cl (1) and Br (2); dmf = N,N-dimethylformamide] have been prepared and characterized. X-ray powder diffraction measurements on samples of 1 and 2 support the same structure for both systems. The crystal structure of 1 was determined by single-crystal X-ray diffraction. 1 crystallizes in the triclinic system with space group Pī. Each iron(II) is six-coordinate and bonded to six oxygens from six dmf molecules building a distorted octahedral environment. Rhenium(IV) is six-coordinate by six halide anions in an almost regular octahedral geometry. The magnetic properties were investigated from variable-temperature magnetic susceptibility measurements performed on microcrystalline samples of 1 and 2, whose experimental data were reproduced by a model of two isolated paramagnetic centers [S = 2 (FeII) and S = 3/2 (ReIV)] with large values of zero-field splitting (zfs) parameter. Keywords: Rhenium(IV) complexes, iron(II) complexes, X-ray diffraction, magnetic properties Sample our Engineering &amp;amp; Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days Journal of Information Display Sign up today for updates in your subject People also read Article Iron(II) complex of 2-(1H-pyrazol-1-yl)pyridine-4-carboxylic acid (ppCOOH) suitable for surface deposition V&amp;iacute;ctor Garc&amp;iacute;a-L&amp;oacute;pez et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 5 Feb 2018 Article Synthesis, X-ray crystal structure and DFT studies of cobalt(II) and vanadium(V) complexes with N,N,O-tridentate aroyl-hydrazone based ligand Mir Abolfazl Naziri et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 1 Published online: 15 Feb 2018 Article Syntheses, crystal structures and antibacterial activities of two new Mn(II) complexes based on triaryltriazoles Shi-Pei Zhang et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 1 Published online: 31 Jan 2018 Article Syntheses and crystal structures of organoindium(III) 1-D coordination polymers with bis(diphenylphosphino)alkane dioxides Clovis Peppe et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 22 Feb 2018 Article Copper(II)-dipicolinate-mediated clickable azide&amp;ndash;alkyne cycloaddition in water as solvent Lahoucine Bahsis et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 5 Published online: 20 Feb 2018 Article Synthesis, characterization and magnetic properties of mixed-valence iron complexes with 2-pyridyl oximes Lorena Mart&amp;iacute;nez et al.</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 &lt;strong&gt;SOBRE&lt;/strong&gt; PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A modified and miniaturized SweEt/QuEChERS method for pesticide residue analysis applied to vine leaves is presented. The deep-frozen plant material was cryogenically processed. A 2 g analytical portion was hydrated for 30 min and extracted with acidified ethyl acetate after buffering with NaHCO3 and adding Na2SO4. A dispersive solid-phase (d-SPE) cleanup step with primary&amp;ndash;secondary amine (PSA) was performed. The pesticide residues were determined using GC-MS/MS. The whole procedure was validated for 54&amp;ndash;59 pesticides at 0.01, 0.02, 0.1, and 0.2 mg/kg in fresh vine leaves (Vitis vinifera). The key method performance parameters investigated were specificity, linearity, trueness, within laboratory repeatability and reproducibility, limit of detection, limit of quantitation, and matrix effects. Recoveries for the 59 pesticides tested ranged from 60 to 110%, and the RSDs were lower than 20% for the majority of the pesticides studied.</text>
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                <text>Journal of Agricultural and Food Chemistry&amp;nbsp; v.66, no. 25, 2018. -- p. 6421-6430</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The inclusion of front of pack (FOP) nutrition labels is one of the strategies that has been proposed to encourage people to make healthful food choices, helping to cope with the increasing burden of overweight and obesity among adults and children. The aim of this study was to evaluate the effect of different FOP labels on Brazilian children and parents&amp;rsquo; healthfulness perception. Children aged 6&amp;ndash;12 years (n = 318) and parents (n = 278) with different socio-economic status rated their perceived healthfulness of eight food products targeted at children using a 7-point scale (1 = not healthful and 7 = very healthful). Participants were randomly allocated into one of the three groups of FOP nutrition labels: Daily Guideline Amounts (GDA), Traffic Light System (TLS) and warning system. Data were analyzed using analysis of variance. For parents, products with the warning system were rated significantly less healthful than those containing the GDA, whereas the TLS did not significantly differ from the other two systems. Age and socio-economic status influenced the effect of FOP labels on children&amp;rsquo;s perceived healthfulness. Only 9&amp;ndash;12 years old children from middle/high socio-economic status were influenced by FOP labels: the warning system and TLS reduced healthfulness perception of frosted corn flakes compared to the GDA system. These results suggest that directive and semi-directive FOP have the potential to modify healthfulness perception of products targeted at children and stress the need to study the modulating effect of individual variables such as age and socio-economic status on the perception of FOP labels.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Miniaturized QuEChERS based methodology for multiresidue determination of pesticides in odonate nymphs as ecosystem biomonitors&lt;/strong&gt;</text>
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                <text>PESTICIDAS</text>
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                <text>RESIDUO DE PESTICIDAS</text>
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                <text>ANALISIS DE PESTICIDAS</text>
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                <text>METODO QUECHERS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>2018</text>
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                <text>The impacts of the modern, agrochemicals based agriculture that threatens the overall systems sustainability, need to be monitored and evaluated. Seeking for agroecosystems monitors, the present article focus in the occurrence and abundance of aquatic macroinvertebrates, that have been frequently used as bioindicators of water quality due to their relationship with land use. Some of these organisms are on the top of the food chain, where bioaccumulation and biomagnification processes can be observed, and they can turn into secondary pollution sources of systems and terrestrial organisms as well. Odonate nymphs, which belong to the functional group of predators, were selected for this study. A methodology to determine 73 pesticide residues in odonate nymphs by LC-MS/MS and GC-MS/MS was developed. A QuEChERS sample preparation strategy was adapted. As it is complex to obtain samples especially in disturbed ecosystems, the method was minimized to a sample size of 200 mg of fresh nymphs. The method was validated and good recoveries (71&amp;ndash;120%) with RSDs below 20% for the majority of the studied pesticides at least at two of the assayed levels 1, 10 and 50 &amp;micro;g kg&amp;minus;1 were obtained. For 32 analytes the limit of quantitation was 1 &amp;micro;g kg&amp;minus;1 and 10 &amp;micro;g kg&amp;minus;1 for the others. The lineal range was observed between 1&amp;ndash;100 &amp;micro;g kg&amp;minus;1 in matrix-matched and solvent calibration curves for most of the assessed pesticides. LC-MS/MS matrix effects were evaluated, 40% of the analytes presented low or no signal suppression. Only flufenoxuron presented high matrix effects. The obtained methodology is adequate for pesticide multiresidue analysis in aquatic macroinvertebrates (odonates) aiming to contribute to the ecological state evaluation of freshwater ecosystems.</text>
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                <text>&lt;strong&gt;Jes&amp;uacute;s, Florencia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Hladki, Ricardo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;G&amp;eacute;rez, Natalia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Besil, Natalia.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Niell, Silvina&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fern&amp;aacute;ndez, Grisel&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=0f8b88f1a07d7ad1bd23900b47efb225" target="_self"&gt;&lt;strong&gt;Heinzen, Horacio.&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Cesio, Mar&amp;iacute;a Ver&amp;oacute;nica.&lt;/strong&gt;</text>
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                <text>Talanta&amp;nbsp; v. 178, 2018. -- p. 410-418</text>
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                <text>Elsevier</text>
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                <text>2018</text>
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            <name>Rights</name>
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              <elementText elementTextId="496325">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>PDF</text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>Ingles</text>
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                <text>Art&amp;iacute;culo</text>
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                <text>DOI: 10.1016/j.talanta.2017.09.014</text>
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        <name>Analisis de pesticidas</name>
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        <name>Pesticidas</name>
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        <name>Residuos de pesticidas</name>
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                  <text>Tesis de doctorado, maestría, trabajos de diploma y monografías técnicas</text>
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                  <text>Versiones electrónicas de las tesis de doctorado, maestría y trabajos de diploma de la Facultad de Química, Universidad de la República (UdelaR).&#13;
Incluye únicamente trabajos hasta el año 2023. Los trabajos posteriores se encuentran disponibles en el Repositorio Colibrí.</text>
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                  <text>Departamento de Documentación y Biblioteca</text>
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                  <text>RIQUIM</text>
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          <name>Original Format</name>
          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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              <text>Papel</text>
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            <name>Title</name>
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                <text>&lt;strong&gt;Metodolog&amp;iacute;a para el aprendizaje de fisica moderna para educacion secundaria con quimica&lt;/strong&gt;</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>FISICA</text>
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                <text>APRENDIZAJE</text>
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                <text>METODOLOGIA PARA EL APRENDIZAJE</text>
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            <name>Abstract</name>
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                <text>El presente trabajo propone una metodolog&amp;iacute;a para el aprendizaje de f&amp;iacute;sica moderna, principalmente para estudiantes que se encuentran cursando los dos &amp;uacute;ltimos a&amp;ntilde;os de bachillerato de ense&amp;ntilde;anza secundaria. Enfoque constructivista del aprendizaje, en donde los estudiantes tienen un rol activo, son responsables de su proceso de construcci&amp;oacute;n de conocimientos y, en donde los docentes act&amp;uacute;an como generadores de situaciones de ense&amp;ntilde;anza para el aprendizaje. La metodolog&amp;iacute;a propuesta se fundamenta en el estudio del estado del arte del aprendizaje de f&amp;iacute;sica moderna en la ense&amp;ntilde;anza secundaria de Uruguay as&amp;iacute; como del an&amp;aacute;lisis de diferentes fuentes de informaci&amp;oacute;n: programas de cursos de f&amp;iacute;sica moderna de nivel terciario universitario y de formaci&amp;oacute;n docente y sus libros de texto m&amp;aacute;s comunes, la opini&amp;oacute;n de informantes claves, programas de f&amp;iacute;sica y qu&amp;iacute;mica de bachillerato de secundaria y metodolog&amp;iacute;as de ense&amp;ntilde;anza con un marco conceptual coherente con el constructivismo. La propuesta metodol&amp;oacute;gica incorpora experimentos que requieren responder preguntas desafiantes para estudiantes secundarios. Varios de los experimentos aqu&amp;iacute; desarrollados fueron implementados en dos cursos de tercero de bachillerato de secundaria, uno de opci&amp;oacute;n cient&amp;iacute;fico-matem&amp;aacute;tico y el otro de opci&amp;oacute;n ciencias-biol&amp;oacute;gicas. Los ejecutores de las propuestas fueron los docentes de estos cursos, en el cient&amp;iacute;fico-matem&amp;aacute;tico un profesor de Qu&amp;iacute;mica y en la opci&amp;oacute;n ciencias-biol&amp;oacute;gicas un profesor de F&amp;iacute;sica. El an&amp;aacute;lisis de los resultados de su implementaci&amp;oacute;n en el aula muestra que los estudiantes se ven atra&amp;iacute;dos y motivados por el desaf&amp;iacute;o de responder preguntas a trav&amp;eacute;s de la experimentaci&amp;oacute;n y aprender con y del otro. Los estudiantes fueron capaces de medir cuidadosamente y analizar los datos obtenidos utilizando planillas de c&amp;aacute;lculo. Es importante destacar que, la introducci&amp;oacute;n de Tecnolog&amp;iacute;as de la Informaci&amp;oacute;n y Comunicaci&amp;oacute;n (PC y tel&amp;eacute;fonos inteligentes, entre otros dispositivos) para realizar los experimentos propuestos, permite disponer de un laboratorio simple, econ&amp;oacute;mico y al alcance de todos. Permitiendo realizar experimentos con distintos grados de Metodolog&amp;iacute;a para el aprendizaje de F&amp;iacute;sica Moderna para Educaci&amp;oacute;n Secundaria con Qu&amp;iacute;mica 8 Jos&amp;eacute; Di Laccio (2018) sofisticaci&amp;oacute;n, que los estudiantes lo pueden realizar en el aula, un parque, en sus propias casas o en el lugar que lo deseen y en el momento que lo prefieran. Varios de los proyectos desarrollados en el contexto de la presente tesis fueron publicados en diversas revistas. Las propuestas educativas desarrolladas aqu&amp;iacute;, han tenido buena acogida en la comunidad educativa regional, en su presentaci&amp;oacute;n en diferentes congresos de ense&amp;ntilde;anza de las ciencias. Algunas de las actividades experimentales innovadoras de esta tesis, fueron premiadas en la convocatoria para presentar experiencias did&amp;aacute;cticas de F&amp;iacute;sica organizada por la Universidad Nacional de Tucum&amp;aacute;n y la Asociaci&amp;oacute;n F&amp;iacute;sica Argentina.</text>
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                <text>&lt;strong&gt;Di Laccio, Jose Luis&lt;/strong&gt;</text>
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            <name>Publisher</name>
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                <text>Montevideo: UdelaR-Facultad de Qu&amp;iacute;mica</text>
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            <name>Date</name>
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                <text>2018</text>
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                <text>&lt;strong&gt;Gil, Salvador&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Zunini, Alice&lt;/strong&gt;</text>
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              <elementText elementTextId="632831">
                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=31ed37f6d0196c1ca18c1b4dfab6de76" target="_self"&gt;&lt;strong&gt;Mombru, Alvaro&lt;/strong&gt;&lt;/a&gt;</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="632832">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Espa&amp;ntilde;ol</text>
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                <text>&lt;strong&gt;Estudios de determinaci&amp;oacute;n de compuestos org&amp;aacute;nicos a niveles traza en matrice complejas&lt;/strong&gt;</text>
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                <text>ESPECTROMETIA DE MASAS</text>
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                <text>El estudio de los contaminantes en los alimentos y el medioambiente es uno de los campos que mayor desarrollo ha experimentado en los &amp;uacute;ltimos tiempos tanto en aspectos regulatorios como anal&amp;iacute;ticos. La diversificaci&amp;oacute;n de las actividades econ&amp;oacute;micas y humanas tendientes hacia una sociedad de consumo, ha generado una variaci&amp;oacute;n en las caracter&amp;iacute;sticas y clases de contaminantes org&amp;aacute;nicos que atentan contra la calidad y sustentabilidad de los recursos. El presente proyecto de tesis tuvo por objetivo el desarrollo y evaluaci&amp;oacute;n de m&amp;eacute;todos y estrategias anal&amp;iacute;ticas cualitativas y cuantitativas para la determinaci&amp;oacute;n de compuestos org&amp;aacute;nicos de relevancia sanitaria y/o ambiental presentes a bajas concentraciones en diferentes matrices como materias primas farmac&amp;eacute;uticas, alimentos y muestras ambientales. 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Se desarrollaron dos metodolog&amp;iacute;as basadas en la t&amp;eacute;cnica MSPD para el an&amp;aacute;lisis multirresiduo de pesticidas en lanolina y prop&amp;oacute;leos, matrices de compleja composici&amp;oacute;n qu&amp;iacute;mica donde la etapa de purificaci&amp;oacute;n es cr&amp;iacute;tica para una buena determinaci&amp;oacute;n. El segundo cap&amp;iacute;tulo aborda el an&amp;aacute;lisis de agroqu&amp;iacute;micos en alimentos. En primera instancia, se comprob&amp;oacute; la posibilidad de determinaci&amp;oacute;n de reguladores de crecimiento en vegetales empleando tratamientos de muestra multirresiduo habituales (m&amp;eacute;todos Luke, QuEChERS y acetato de etilo) para el an&amp;aacute;lisis de con determinaci&amp;oacute;n por sistemas LC-MS/MS. Por otro lado se realiz&amp;oacute; una evaluaci&amp;oacute;n preliminar a la contribuci&amp;oacute;n del consumo de yerba mate a la ingesta diaria de pesticidas por la poblaci&amp;oacute;n uruguaya, a partir de un dispositivo espec&amp;iacute;fico para evaluar la extracci&amp;oacute;n de pesticidas en condiciones de ingesta t&amp;iacute;pica del mate. RESUMEN 13 Se comprob&amp;oacute; que la extractabilidad de residuos y por lo tanto la ingesta de de pesticidas se puede relacionar con las propiedades fisicoqu&amp;iacute;micas de los pesticidas en estudio. En el tercer cap&amp;iacute;tulo, se describe la principal v&amp;iacute;a de transformaci&amp;oacute;n ambiental del antibi&amp;oacute;tico amoxicilina monitoreada en aguas residuales y aguas de r&amp;iacute;o. Posteriormente se expone la posibilidad de evaluaci&amp;oacute;n de contaminantes emergente en aguas empleando diversos arreglos instrumentales. Son expuestas las fortalezas y debilidades de diversas estrategias anal&amp;iacute;ticas especialmente enfocadas hacia instrumentos QTOF en experimentos dedicados a confirmaci&amp;oacute;n de identidad y estrategias de screening automatizado combinado con motores de b&amp;uacute;squeda basados en bases de datos de masas exactas. Se ha observado que las estrategias basadas en detecci&amp;oacute;n asistida por software generalmente necesitan una etapa adicional de confirmaci&amp;oacute;n. Un instrumento QTOF en modo MS/MS permiti&amp;oacute; confirmar o rechazar la identidad de la mayor&amp;iacute;a de los hallazgos de screening de contaminantes emergentes en muestras reales a pesar de que existen limitaciones de sensibilidad anal&amp;iacute;tica y efecto matriz. Se compararon adem&amp;aacute;s estrategias cuantitativas y cualitativas basada en el an&amp;aacute;lisis por inyecci&amp;oacute;n directa de muestras acuosas por LC-MS/MS empleando instrumentos QLIT para un grupo representativo de contaminantes emergentes operando en modo SRM y en modo IDA. La mayor sensibilidad de los instrumentos QLIT-MS/MS ofrece la posibilidad de realizar an&amp;aacute;lisis cuantitativo de variedad de contaminantes por inyecci&amp;oacute;n directa de la muestra, reduciendo el efecto de la matriz y aumentando de la confiabilidad de los resultados. Durante esta tesis, se ha logrado cubrir los distintos aspectos del an&amp;aacute;lisis de trazas contemplando desde estrategias de preparaci&amp;oacute;n de muestra, expansi&amp;oacute;n del alcance de m&amp;eacute;todos preexistentes y caracterizaci&amp;oacute;n de contaminantes antropog&amp;eacute;nicos, empleando distintas t&amp;eacute;cnicas instrumentales y de tratamientos de datos que permiten la realizaci&amp;oacute;n de experimentos &amp;uacute;tiles tanto en cuantificaci&amp;oacute;n, identificaci&amp;oacute;n preliminar, confirmaci&amp;oacute;n y elucidaci&amp;oacute;n estructural de contaminantes org&amp;aacute;nicos.</text>
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                <text>&lt;strong&gt;P&amp;eacute;rez Parada, Andr&amp;eacute;s&lt;/strong&gt;</text>
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                <text>Montevideo: UdelaR-Facultad de Qu&amp;iacute;mica</text>
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                <text>&lt;strong&gt;&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=0f8b88f1a07d7ad1bd23900b47efb225" target="_self"&gt;Heinzen, Horacio (director de Tesis&lt;/a&gt;)&lt;/strong&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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            <name>Publisher</name>
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                  <text>Bibliografía Nacional Química</text>
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              <description>An account of the resource</description>
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                  <text>Departamento de Documentación y Biblioteca</text>
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                <text>&lt;strong&gt;Noncompetitive Homogeneous Detection of Small Molecules Using Synthetic Nanopeptamer-Based Luminescent Oxygen Channeling&lt;/strong&gt;</text>
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                <text>PEPTIDOS</text>
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                <text>PEQUE&amp;Ntilde;AS MOLECULAS</text>
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                <text>OXIGENO LUMINISCENTE</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>Our group has previously developed immunoassays for noncompetitive detection of small molecules based on the use of phage borne anti-immunocomplex peptides. Recently, we substituted the phage particles by biotinylated synthetic anti-immunocomplex peptides complexed with streptavidin and named these constructs nanopeptamers. In this work, we report the results of combining AlphaLisa, a commercial luminescent oxygen channeling bead system, with nanopeptamers for the development of a noncompetitive homogeneous assay for the detection of small molecules. The signal generation of AlphaLisa assays relies on acceptor-donor bead proximity induced by the presence of the analyte (a macromolecule) simultaneously bound by antibodies immobilized on the surface of these beads. In the developed assay, termed as nanoAlphaLisa, bead proximity is sustained by the presence of a small model molecule (atrazine, MW = 215) using an antiatrazine antibody captured on the acceptor bead and an atrazine nanopeptamer on the donor bead. Atrazine is one of the most used pesticides worldwide, and its monitoring in water has relevant human health implications. NanoAlphaLisa allowed the homogeneous detection of atrazine down to 0.3 ng/mL in undiluted water samples in 1 h, which is 10-fold below the accepted limit in drinking water. NanoAlphaLisa has the intrinsic advantages for automation and high-throughput, simple, and fast homogeneous detection of target analytes that AlphaLisa assay provides.</text>
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                <text>&lt;strong&gt;Lassabe, Gabriel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Kramer, Karl&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Hammock, Bruce D.&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=7ee0def1187be47e0710e877d9768b5a" target="_self"&gt;&lt;strong&gt;Gonz&amp;aacute;lez Sapienza, Gualberto&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Analytical Chemistry v. 90, no. 10, 2018. -- p. 6187-6192</text>
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            <name>Publisher</name>
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              <elementText elementTextId="496136">
                <text>American Chemical Society</text>
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            <name>Date</name>
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              <elementText elementTextId="496138">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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            <description>The nature or genre of the resource</description>
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                <text>DOI: 10.1021/acs.analchem.8b04536</text>
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            <description>The topic of the resource</description>
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                <text>&lt;strong&gt;LIMONES&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;GOMAS&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;LEMON GUM&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;CITRUS LEMON GUM&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;POLYSACCHARIDE&lt;/strong&gt;</text>
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        <name>Gomas</name>
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      <tag tagId="6035">
        <name>Lemon gum</name>
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                <text>Using the flexible ligand oxydiacetic acid (H2oda), ten new heteropolynuclear compounds with general formula [Ln2Zn3(oda)6]&amp;middot;xH2O (Ln = lanthanide ion, oda = oxydiacetate) were synthesized and structurally characterized. They were prepared by the direct reaction of oda in aqueous solution with stoichiometric amounts of Zn and Ln salts, followed by slow organic solvent diffusion. Two different structures were obtained: the larger lanthanides Pr, Nd, Eu and Tb gave compounds belonging to the hexagonal system, space group P6/mcc; whereas, the smaller ones, Ho, Er, Yb and Y formed cubic systems, space group Fd[3 with combining macron]c. In the case of Dy, the two polymorphs were obtained by slight variations in the synthetic conditions. The phase change observed is discussed in comparison with previously reported [Ln2M3(oda)6]&amp;middot;xH2O compounds (M = bivalent metal ion). Luminescence studies were also carried out. Compounds containing Eu and Tb showed the most intense luminescence, also bearing relatively long lifetimes for the excited state deactivation. The luminescence profiles of both Dy systems are independent of the hexagonal or cubic arrangements, due to the similar environment of the Ln having the same point symmetry.</text>
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                <text>Phage borne peptides isolated from phage libraries have proven to be valuable reagents for the development of small-molecule immunoassays. However, the large size, low diffusion rate, and biological nature of the phage particles create some limitations to their use and require secondary reagents for its detection. In this work, we explore the use of the Nano luciferase (NanoLuc) as a fusion partner to generate recombinant tracers for immunoassay development. The imidaclothiz peptidomimetic C2-15 that specifically binds to the anti-imidaclothiz monoclonal antibody (mAb) 1E7 was fused to NanoLuc, both at the N terminus (C2-15-NanoLuc) and C terminus (NanoLuc-C2-15). NanoLuc-C2-15 showed better performance than C2-15-NanoLuc and was adopted to develop a bioluminescent enzyme immunoassay (BLEIA) and a bioluminescence lateral flow immunoassay (BLLFIA) for imidaclothiz. The luminescence signal of NanoLuc-C2-15 rapidly reaches high intensity with slow attenuation, which enabled one to capture the BLLFIA readout by using a smartphone without an external light source. The IC50 of the BLEIA and BLLFIA were 3.3 &amp;plusmn; 0.2 and 6.4 &amp;plusmn; 0.4 ng mL-1, respectively. Both immunoassays exhibited good accuracy for the detection of imidaclothiz in environmental and agricultural samples.</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>We investigated the occurrence of cycloadditions on dimensional boron nitride. Our results indicated that the [2 + 2] cycloaddition of benzynes, ethyne, and maleic anhydride is allowed both from thermodynamical and kinetic stand points. In fact, our results indicated that the reaction energy associated with the formation of the [2 + 2] cycloaddition product is more exothermic than that computed for graphene. The activation energy determined for the [2 + 2] path is 15.9 kcal/mol, suggesting the feasibility of the process. Furthermore, we found that the activation energy for the retro reaction is 30.6 kcal/mol. This value is large enough to guarantee the stability of the functional groups but not too high to impede their detachment upon heating. In addition to these findings, we found that cycloadditions can be used to reduce the band gap of boron nitride nanosheets. In light of these results, we propose the use of cycloaddition reactions to attain the temperature-controlled functionalization of boron nitride sheets.</text>
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                <text>Journal of Physical Chemistry C v. 122, no. 32, 2018. -- p. 18583-18587</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The goal of our study was to improve Tannat grape and wine composition by achieving vine balance in high-capacity conditions. The current Uruguayan grape-growing paradigm accepts unpredictable periods of water deficit or excess in non-irrigated vineyards, only applying herbicides to eliminate weed competition (H). We used an under-trellis cover crop (UTCC) to limit vine water availability and to reduce vine growth rate and final canopy size. However, to avoid excessive vine water stress due to UTCC competition, irrigation was used as needed during water deficit periods. The experiment was conducted over three consecutive growing seasons from 2011 to 2013, in two experimental vineyards located in southern Uruguay (34&amp;deg; S 56&amp;deg; W). Treatments were: UTCC (full cover of the vineyard soil with tall fescue) versus conventional alleyway tall fescue with a 1.0 m-wide weed-free strip under the trellis. Deficit drip irrigation was provided at mid-day stem water potential (SWP) thresholds of &amp;minus;0.9 MPa early in the season and &amp;minus;1.1 MPa later. Shoot growth rate, SWP, berry size and berry composition (Brix, organic acids, total anthocyanins) were monitored over the season as well as final yield, cluster and pruning weights and wine sensory attributes. UTCC regulated vine vegetative growth and final canopy size and reduced bunch rot incidence as well as increasing fruit Brix and anthocyanin concentration in grapes and wines. Wines from UTCC treatments had an increased fruity aroma and overall aroma intensity levels and had distinctive sensory characteristics that exceeded those of H wines during overall palatability tests (liking tests).</text>
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                <text>&lt;strong&gt;Coniberti Mundy, Andr&amp;eacute;s.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ferrari, V.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Disegna, Edgardo.&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2df81feedac99473a4e536d2623f04c3" target="_self"&gt;&lt;strong&gt;Dellacassa, Eduardo.&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Scientia Horticulturae v. 235, 2018. -- p. 244-252</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA - &lt;/strong&gt;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses&lt;/strong&gt;</text>
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                <text>Commercially available saponins are extracted from Quillaja saponaria barks, being Quil A&amp;reg; the most widely used. Nanoparticulate immunostimulating complexes (ISCOMs or ISCOMATRIX) formulated with these, are able to stimulate strong humoral and cellular immune responses. Recently, we formulated novel ISCOMs replacing QuilA&amp;reg; by QB-90 (IQB-90), a Quillaja brasiliensis leaf-extracted saponin fraction, and reported that IQB-90 improved antigen uptake, and induced systemic and mucosal antibody production, and T-cell responses. However, its mechanism of action remains unclear. In this study we provide a deeper insight into the immune stimulatory properties of QB-90 and ISCOMATRIX-like based on this fraction (IMXQB-90). We show herein that, when used as a viral vaccine adjuvant, QB-90 promotes an &amp;ldquo;immunocompetent environment&amp;rdquo;. In addition, QB-90 and IMXQB-90 induce immune-cells recruitment at draining-lymph nodes and spleen. Subsequently, we prove that QB-90 or IMXQB-90 stimulated dendritic cells secret IL-1&amp;beta; by mechanisms involving Caspase-1/11 and MyD88 pathways, implying canonical inflammasome activation. Finally, both formulations induce a change in the expression of cytokines and chemokines coding genes, many of which are up-regulated. Findings reported here provide important insights into the molecular and cellular mechanisms underlying the adjuvant activity of Q. brasiliensis leaf-saponins and its respective nanoparticles.</text>
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                <text>Scientific Reports v. 8, no. 1, 2018. --15p.-- e13582</text>
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                <text>Springer Nature Limited</text>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="495498">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Leaf saponins of Quillaja brasiliensis enhance long-term specific immune responses and promote dose-sparing effect in BVDV experimental vaccines&lt;/strong&gt;</text>
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                <text>INMUNOLOGIA</text>
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                <text>QUILLAJA BRASILIENSIS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>2018</text>
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                <text>Saponin-based adjuvants are promising adjuvants that enhance both humoral and T-cell-mediated immunity. One of the most used natural products as vaccine adjuvants are Quillaja saponaria bark saponins and its fraction named Quil A&amp;reg;. Despite that, its use has been restricted for human use due to safety issues. As an alternative, our group has been studying the congener species Quillaja brasiliensis saponins and its performance as vaccine adjuvants, which have shown to trigger humoral and cellular immune responses comparable to Quil A&amp;reg; but with milder side effects. Here, we studied a semi purified aqueous extract (AE) and a previously little characterized saponin-enriched fraction (QB-80) from Q. brasiliensis as vaccine adjuvants and an inactivated virus (bovine viral diarrhea virus, BVDV) antigen co-formulated in experimental vaccines in mice model. For the first time, we show the spectra pattern of the Q. brasiliensis saponins by MALDI-TOF, a novel and cost-effective method that could be used to characterize different batches during saponins production. Both AE and QB-80 exhibited noteworthy chemical similarities to Quil A&amp;reg;. In addition, the haemolytic activity and toxicity were assessed, showing that both AE and QB-80 were less toxic than Quil A&amp;reg;. When subcutaneously inoculated in mice, both fractions promoted long-term strong antibody responses encompassing specific IgG1 and IgG2a, enhanced the avidity of IgG antibodies, induced a robust DTH reaction and significantly increased IFN-ɣ production in T CD4+ and T CD8+ cells. Furthermore, we have proven herein that AE has the potential to promote dose-sparing, substantially reducing the dose of antigen required for the BVDV vaccines and still eliciting a mixed Th1/Th2 strong immune response. Based on these results, and considering that AE is a raw extract, easier and cheaper to produce than commercially available saponins, this product can be considered as candidate to be escalated from experimental to industrial uses.</text>
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                <text>&lt;strong&gt;Cibulski, Samuel&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rivera Patr&amp;oacute;n, Mariana.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Pirez, Macarena&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rossi, Silvina&lt;/strong&gt;</text>
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                <text>Vaccine&amp;nbsp; v. 36, 2018. -- p. 55-65</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="495468">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Ozono en hospitales y laboratorios como desinfectante, bactericida, etc.&amp;nbsp; : en cirug&amp;iacute;a, en todos los ambientes&lt;/strong&gt;</text>
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          <elementSet elementSetId="5">
            <name>Omeka Image File</name>
            <description>The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.</description>
            <elementContainer>
              <element elementId="74">
                <name>Bit Depth</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="495362">
                    <text>8</text>
                  </elementText>
                </elementTextContainer>
              </element>
              <element elementId="75">
                <name>Channels</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="495363">
                    <text>3</text>
                  </elementText>
                </elementTextContainer>
              </element>
              <element elementId="73">
                <name>Height</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="495366">
                    <text>84</text>
                  </elementText>
                </elementTextContainer>
              </element>
              <element elementId="72">
                <name>Width</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="495367">
                    <text>146</text>
                  </elementText>
                </elementTextContainer>
              </element>
            </elementContainer>
          </elementSet>
        </elementSetContainer>
      </file>
    </fileContainer>
    <itemType itemTypeId="1">
      <name>Document</name>
      <description>A resource containing textual data.  Note that facsimiles or images of texts are still of the genre text.</description>
      <elementContainer>
        <element elementId="7">
          <name>Original Format</name>
          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
          <elementTextContainer>
            <elementText elementTextId="495379">
              <text>Papel</text>
            </elementText>
          </elementTextContainer>
        </element>
      </elementContainer>
    </itemType>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="495368">
                <text>&lt;strong&gt;Lentes de contacto : solucioes de limpieza, soluciones de mantenimiento, soluciones para su aplicaci&amp;oacute;n para distintos tipos, preparaci&amp;oacute;n de dichas soluciones&lt;/strong&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
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                <text>&lt;strong&gt;LENTES DE CONTACTO&lt;/strong&gt;</text>
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              <elementText elementTextId="495370">
                <text>&lt;strong&gt;SOLUCIONES (LIQUIDOS)&lt;/strong&gt;</text>
              </elementText>
              <elementText elementTextId="495371">
                <text>&lt;strong&gt;TECNICAS DE PRODUCCION&lt;/strong&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="495372">
                <text>Biblioteca-FQ</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="495373">
                <text>1989</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="495374">
                <text>Papel</text>
              </elementText>
              <elementText elementTextId="495375">
                <text>PDF</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="495376">
                <text>Ingl&amp;eacute;s</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="495377">
                <text>Bibliograf&amp;iacute;a</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="116">
            <name>Temporal Coverage</name>
            <description>Temporal characteristics of the resource.</description>
            <elementTextContainer>
              <elementText elementTextId="495378">
                <text>1968-1986</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="6019">
        <name>Lentes de contacto</name>
      </tag>
      <tag tagId="5895">
        <name>Soluciones (líquidos)</name>
      </tag>
      <tag tagId="4427">
        <name>Técnicas de producción</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
