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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>ZrCr1-xNiMox (x = 0.0, 0.3 and 0.6 corresponding to 0, 13 and 25% w/w Mo content respectively) alloys with initial particle sizes of 38&amp;ndash;63 &amp;mu;m and 63&amp;ndash;125 &amp;mu;m were studied. Alloys were characterized by X-ray diffraction, revealing that molybdenum substitution by chromium produces the segregation of ZrxNiy phases, ZrCr2 and ZrMo2 Laves phases. Electrodes with 13% of molybdenum depicted the highest discharge capacity of 300 mA h g&amp;minus;1. In all cases, the smallest initial particle size exhibited the highest hydrogen storage capacity. On the other hand, the increase of nickel content in the composition of the secondary phase (Zr7Ni10 comparing to Zr9Ni11) leds to an improvement in high rate discharge ability behavior. Hydrogen evolution reaction analysis showed that electrodes with 13% of molybdenum described the largest current intensities. The reaction rds was related to the type of secondary phase dominant in each sample, whereas self-discharge behavior was associated to the presence of molybdenum phases. Thereby, the alloy with 13% weight in molybdenum was the one which improves electrocatalytic performance for hydrogen storage purposes.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text> ANTIBACTERIANOS</text>
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                <text>BIOSINTESIS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>Silver nanoparticles have particular properties that contribute to their very promising applications, novel in various fields of science, such as the development of biosensors, the diagnosis and treatment of cancer, the controlled release of drugs and the antimicrobial potential. The biological synthesis of nanoparticles is of great interest over other physical and chemical methods because the use of toxic chemicals and drastic reaction conditions are avoided. The extracellular biosynthesis using fungi could also make downstream processing much easier than the intracellular biosynthesis. One of the main applications of silver nanoparticles is their antimicrobial activity. Several studies have demonstrated the bactericidal properties of silver nanoparticles are different from silver ions, and that they are strongly influenced by their shape, size, concentration and colloidal state. In the present work, the ability of fungal strains from Uruguay to synthesize silver nanoparticles was studied. Eight fungi were able to synthesize nanoparticles. An extensive physicochemical characterization of the nanoparticles was carried out including ultraviolet-visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta-potential and gel electrophoretic mobility. According to the characterization and colloidal stability results, nanoparticles from three fungi were selected for antimicrobial activity assays. All nanoparticles were able to inhibit Escherichia coli growth, demonstrating their potential as effective antibacterial agent for use in biomedical applications.</text>
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                <text>&lt;strong&gt;Sangui&amp;ntilde;edo, Paula&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fratila, Raluca Mar&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Estevez, Mar&amp;iacute;a Bel&amp;eacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mart&amp;iacute;nez de la Fuente, Jes&amp;uacute;s&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Graz&amp;uacute;, Valeria&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Albor&amp;eacute;s, Silvana&lt;/strong&gt;</text>
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                <text>Nano Biomedicine and Engineering v. 10, no. 2, 2018. -- p. 165-173</text>
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            <name>Publisher</name>
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                <text>OAHOST</text>
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            <name>Date</name>
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            <name>Rights</name>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>PDF</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>Art&amp;iacute;culo</text>
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                <text>DOI: 10.5101/nbe.v10i2.p156-164.</text>
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          <name>Original Format</name>
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            <name>Title</name>
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            <elementTextContainer>
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                <text>&lt;strong&gt;Investigaci&amp;oacute;n de zinc, investigaci&amp;oacute;n de cobre, investigaci&amp;oacute;n de zinc y cobre : en plasma por espectroscop&amp;iacute;a de absorci&amp;oacute;n at&amp;oacute;mica&lt;/strong&gt;</text>
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            <name>Subject</name>
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                <text>&lt;strong&gt;CINC&lt;/strong&gt;</text>
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              <elementText elementTextId="493913">
                <text>&lt;strong&gt;COBRE&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;PLASMA SANGUINEO&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;ESPECTROSCOPIA ATOMICA&lt;/strong&gt;</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="493916">
                <text>Biblioteca-FQ</text>
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                <text>Papel</text>
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                <text>PDF</text>
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            <description>A language of the resource</description>
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                <text>Ingl&amp;eacute;s</text>
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        <name>Espectroscopía atómica</name>
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        <name>Plasma sanguineo</name>
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&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A new mononuclear complex of zinc(II), [Zn(HL)2]∙2DMF (H2L = (E)-N&amp;prime;-((E)-(hydroxyimino)butan-2-ylidene)salicyloylhydrazide, DMF = N,N-dimethylformamide), was prepared and characterized. Single-crystal X-ray crystallography revealed a six-coordinate zinc(II) surrounded by nitrogen of the oxime function and oxygen and distal nitrogens of the acylhydrazone group. This entity also exists in solution as demonstrated by 1H-NMR and potentiometric titrations. The computational analysis showed that the molecular orbitals involved in the main electronic transitions of the complex species in solution are centered on the ligand with negligible contribution of the metal ion. The photophysical properties of the complex were evaluated in solution and in the solid state. Luminescence studies showed that the solid has a strong emission at 550 nm with a large Stokes shift with respect to absorption. The solid state fluorescence emission is ascribed to ligand-centered and/or ligand-to-ligand charge transfer transitions, following the DFT results in solution. A comparison with a previously reported mononuclear [Zn(HL)2] allowed the investigation of the influence of DMF molecules in the structural packing and the luminescence properties.</text>
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                <text>Journal of Coordination Chemistry v. 71, 2018. -- p. 874-889</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>wo new mixed-valence iron complexes with 2-pyridyl oximes, [Fe(mpko)3Fe(H2O)2(NO3)](NO3)&amp;middot;2H2O (1) (mpko&amp;minus; = methyl(2-pyridyl)ketone oximate) and [{Fe(dpko)3}2Fe](ClO4)&amp;middot;4H2O (2) (dpko&amp;minus; = bis(2-pyridyl)ketone oximate), have been prepared by reaction of FeIII with mpkoH in methanol (1) and FeII with dpkoH in methanol/water (2). Dinuclear FeII(low-spin)FeIII(high-spin) and trinuclear FeII(low-spin)FeIII(high-spin)FeII(low-spin) cations are present in the crystal structure of 1 and 2, respectively. Intermolecular hydrogen bonds in 1 lead to weak antiferromagnetic interactions between pairs of neighboring FeIII centers, which allows observation of single-ion zero-field splitting effects. Keywords: Iron(II)/(III) complexes, methyl(2-pyridyl)ketone oxime, bis(2-pyridyl)ketone oxime, magnetic exchange mediated by hydrogen bonds, crystal structure Sample our Engineering &amp;amp; Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days Publish open access with the Journal of Information and Telecommunications Sign up today for updates in your subject People also read Article Cu(II) complexes of cytosine and 1-methylcytosine with bromide: old motifs and new structures Rosaria Bruno et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 5 Published online: 23 Feb 2018 Article Structural studies on Ba(II) adducts of the cytosine nucleobase and its derivative 1-Methylcytosine Nadia Marino et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 23 Feb 2018 Article Hexakis(dimethylformamide)iron(II) complex cation in hexahalorhenate(IV)-based salts: synthesis, X-ray structure and magnetic properties Carlos Rojas-Dotti et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 19 Jan 2018 Article Iron(II) complex of 2-(1H-pyrazol-1-yl)pyridine-4-carboxylic acid (ppCOOH) suitable for surface deposition V&amp;iacute;ctor Garc&amp;iacute;a-L&amp;oacute;pez et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 5 Feb 2018 Article A Zn(II) luminescent complex with a Schiff base ligand: solution, computational and solid state studies Sebasti&amp;aacute;n Mart&amp;iacute;nez et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 6 Published online: 19 Feb 2018 Article Magneto-structural correlations in asymmetric oxalato-bridged dicopper(II) complexes with polymethyl-substituted pyrazole ligands M. Luisa Calatayud et al. Journal of Coordination Chemistry Volume 71, 2018 - Issue 5 Published online: 12 Jan 2018</text>
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                <text>Journal of Coordination Chemistry&amp;nbsp; v. 71, no. 6, 2018. -- p. 748-762</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Combined molecular modelling and 3D-QSAR study for understanding the inhibition of NQO1 by heterocyclic quinone derivatives&lt;/strong&gt;</text>
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                <text>A combination of three-dimensional quantitative structure-activity relationship (3D-QSAR), and molecular modelling methods were used to understand the potent inhibitory NAD(P)H:quinone oxidoreductase 1 (NQO1) activity of a set of 52 heterocyclic quinones. Molecular docking results indicated that some favourable interactions of key amino acid residues at the binding site of NQO1 with these quinones would be responsible for an improvement of the NQO1 activity of these compounds. The main interactions involved are hydrogen bond of the amino group of residue Tyr128, &amp;pi;-stacking interactions with Phe106 and Phe178, and electrostatic interactions with flavin adenine dinucleotide (FADH) cofactor. Three models were prepared by 3D-QSAR analysis. The models derived from Model I and Model III, shown leave-one-out cross-validation correlation coefficients (q2LOO ) of .75 and .73 as well as conventional correlation coefficients (R2 ) of .93 and .95, respectively. In addition, the external predictive abilities of these models were evaluated using a test set, producing the predicted correlation coefficients (r2pred ) of .76 and .74, respectively. The good concordance between the docking results and 3D-QSAR contour maps provides helpful information about a rational modification of new molecules based in quinone scaffold, in order to design more potent NQO1 inhibitors, which would exhibit highly potent antitumor activity.</text>
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                <text>&lt;strong&gt;L&amp;oacute;pez Lira, Claudia&lt;/strong&gt;</text>
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                <text>Chemical Biology and Drug Design&amp;nbsp; v. 91, no. 1, 2018. -- p. 29-38</text>
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Mycobacterium tuberculosis , el agente etiol&amp;oacute;gico de la tuberculosis, es la se gunda causa de muerte por un agente infeccioso a nivel mu ndial. PknG, una Ser/Thr-quinasa de prote&amp;iacute;nas, es un factor crucial para la sobrevid a de esta bacteria en el hospedero. Con el fin de elucidar las v&amp;iacute;as de se&amp;ntilde;alizaci&amp;oacute;n med iadas por PknG, recientemente estudiamos su interactoma e identificamos nuevos su stratos de esta quinasa. En el presente trabajo nos centramos en una de las prote&amp;iacute; nas fosforiladas por PknG: la prote&amp;iacute;na FhaA. Esta prote&amp;iacute;na tiene una estructura q ue se asemeja a las prote&amp;iacute;nas de andamiaje que participan en v&amp;iacute;as de se&amp;ntilde;alizaci&amp;oacute;n de eucariotas, con un dominio N- terminal de funci&amp;oacute;n desconocida y un dominio C-term inal FHA que reconoce espec&amp;iacute;ficamente de treoninas fosforiladas, ambos unidos por una secue ncia de aproximadamente 300 residuos sin estructura definid a. Como primer paso hacia la elucidaci&amp;oacute;n del rol de esta prote&amp;iacute;na nos propusimos la caracterizaci&amp;oacute;n a nivel molecular de los complejos de se&amp;ntilde;alizaci&amp;oacute;n formados in vivo por FhaA, as&amp;iacute; como sus cambios din&amp;aacute;micos frente a diferentes est&amp;iacute;mulos que simulen el ambiente del hospedero. La estrategia experimental utilizada se basa en la sobre-expresi&amp;oacute;n de FhaA conteniendo una etiqueta (Strep-tag) en Mycobacterium smegmatis en combinaci&amp;oacute;n con el entrecruzamiento de prote&amp;iacute;nas in vivo , purificaci&amp;oacute;n por afinidad y espectrometr&amp;iacute;a de masa para obtener una instant&amp;aacute;nea de los complejos de se&amp;ntilde;alizaci&amp;oacute;n. Nuestros resultados nos permitieron i dentificar 56 interactores de FhaA, entre los que se incluye el &amp;uacute;nico interactor previa mente reportado [1]. Los nuevos interactores identificados nos permiten postular qu e esta prote&amp;iacute;na cumple un rol tanto en la s&amp;iacute;ntesis de pared como en la regulaci&amp;oacute; n de la divisi&amp;oacute;n celular en la micobacteria. Con el fin de evaluar la contribuci&amp;oacute;n de la fosfo rilaci&amp;oacute;n de FhaA a las interacciones descritas, nos proponemos estudiar el intera</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Ensamblaje supramolecular de complejos polinucleares mediante derivados del &amp;aacute;cido iminodiac&amp;eacute;tico&lt;/strong&gt;</text>
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                <text>El dise&amp;ntilde;o y construcci&amp;oacute;n de estructuras supramoleculares polinucleares de iones lant&amp;aacute;nidos es un campo de investigaci&amp;oacute;n de gran inter&amp;eacute;s. Ellas presentan interesantes arquitecturas y propiedades, ya sea magn&amp;eacute;ticas, &amp;oacute;pticas, el&amp;eacute;ctricas, etc. Los lant&amp;aacute;nidos (Ln) en su estado de oxidaci&amp;oacute;n +3, son iones ideales para el dise&amp;ntilde;o de estas estructuras polim&amp;eacute;ricas, debido a sus altos &amp;iacute;ndices de coordinaci&amp;oacute;n que permiten construir fascinantes estructuras t&amp;eacute;rmicamente estables. El futuro de este tipo de complejos depende de continuar la b&amp;uacute;squeda de nuevos compuestos y del cuidadoso dise&amp;ntilde;o y control de la arquitectura final generada. La selecci&amp;oacute;n del ligando utilizado es crucial para el dise&amp;ntilde;o de estos compuestos. Un tipo de ligandos de amplio estudio por formar complejos de gran estabilidad y ofrecer diversos modos de coordinaci&amp;oacute;n son los ligandos policarbox&amp;iacute;licos. En particular el &amp;aacute;cido iminodiac&amp;eacute;tico (H2ida) ha mostrado una sorprendente versatilidad gracias a su gran flexibilidad y diversos modos de coordinaci&amp;oacute;n. Varias estructuras polinucleares se han reportado con este ligando, siendo relevante la serie [Ln(Hida)3]&amp;middot;xH2O. La particularidad de estos compuestos es la formaci&amp;oacute;n de estructuras tridimensionales que contienen canales de unos 11 &amp;Aring; de di&amp;aacute;metro. Es de destacar que en estas estructuras se observa la capacidad de este ligando de pasar de ser un ligando tridentado ONO, a un ligando dit&amp;oacute;pico, que puede coordinar centros met&amp;aacute;licos alejados. La protonaci&amp;oacute;n del &amp;aacute;tomo de N es la responsable de estos cambios. En esta misma l&amp;iacute;nea, otras estructuras porosas han sido reportadas para complejos heteropolinucleares conteniendo iones lant&amp;aacute;nidos, metales de transici&amp;oacute;n 3d y el ligando ida. Un ejemplo de estos son los complejos isoestructurales del tipo [Ln2Cu3(ida)6]&amp;middot;xH2O. Con estos antecedentes, el objetivo de este trabajo es sintetizar nuevas series de complejos polinucleares conteniendo iones lant&amp;aacute;nidos y ligandos aminodicarbox&amp;iacute;licos N-sustituidos derivados del iminodiacetato y caracterizarlos del punto de vista estructural y de sus propiedades. Los ligandos aqu&amp;iacute; empleados son el &amp;aacute;cido N-hidroxietiliminodiac&amp;eacute;tico (H2hida), el &amp;aacute;cido N-benciliminodiac&amp;eacute;tico (H2bzlida), el &amp;aacute;cido N-metiliminodiac&amp;eacute;tico (H2mida) y el &amp;aacute;cido Nmetiliminodipropi&amp;oacute;nico (H2midp). Con el fin de determinar las mejores condiciones de s&amp;iacute;ntesis se realizaron estudios potenciom&amp;eacute;tricos en soluci&amp;oacute;n acuosa. A partir de estos fue posible determinar las especies principales en soluci&amp;oacute;n y el rango de pH en el cual pueden ser aislados al estado s&amp;oacute;lido. Luego se pas&amp;oacute; a la etapa de s&amp;iacute;ntesis, donde se obtuvieron nuevos complejos polinucleares con todos los ligandos: [Ln(bzlida)(Hbzlida)]&amp;middot;H2O (Ln = La, Nd), [Ln2(bzlida)3]&amp;middot;3H2O (L n= Nd, Sm, Eu, Gd), [Ho(hida)(H2O)2](CF3SO3)&amp;middot;xH2O, [Sm(Hmida)2(H2O)2]&amp;middot;ClO4&amp;middot;H2O&amp;middot;1/6NaClO4 y [Ln2(Hmidp)3(H2O)3](ClO4)3&amp;middot;3H2O (Ln = Nd, Sm, Eu, Gd, Tm, Dy, Ho). Los complejos fueron caracterizados completamente incluyendo su elucidaci&amp;oacute;n estructural mediante difracci&amp;oacute;n de rayos X. Finalmente se evaluaron las propiedades &amp;oacute;pticas y magn&amp;eacute;ticas de una selecci&amp;oacute;n de los compuestos obtenidos. Esto permiti&amp;oacute; relacionar las estructuras obtenidas con las propiedades al estado s&amp;oacute;lido. El estudio de sus propiedades &amp;oacute;pticas permiti&amp;oacute; determinar que es posible una Resumen 2 transferencia de energ&amp;iacute;a desde los ligandos a los centros met&amp;aacute;licos, aunque la eficiencia de la transferencia es baja, siendo los compuestos de Eu los que arrojan los mejores resultados. Al evaluar las propiedades magn&amp;eacute;ticas se pudo racionalizar el origen del acoplamiento antiferromagn&amp;eacute;tico en el compuesto [Gd2(bzlida)3]&amp;middot;3H2O. El estudio permiti&amp;oacute; por primera vez estudiar el acoplamiento de intercambio magn&amp;eacute;tico entre dos iones de Gd(III) a trav&amp;eacute;s de un puente triple &amp;mu;-oxo(carboxilato</text>
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                <text>Montevideo: UdelaR-Facultad de Qu&amp;iacute;mica</text>
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                <text>&lt;strong&gt;Kremer, Carlos (Director de Tesis)&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Torres, Julia (Directora de Tesis)&lt;/strong&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Glutathione transferases (GSTs) perform several catalytic and non-catalytic roles in the defense against toxicities of electrophile compounds and oxidative stress, and therefore are involved in stress-response and cell detoxification. Previously, we have provided evidence indicating that EgGST2 and EgGST3, two phylogenetically distant Echinococcus granulosus GSTs, can naturally form a heterodimeric structure (EgGST2-3). In the present work, the recombinant heterodimer GST (rEgGST2-3) is characterized. Hence, rEgGST2-3 was able to conjugate GSH to three substrates: 1-chloro-2,4-dinitrobenzene (CDNB, general substrate for GSTs), 1,2-dichloro-4-nitrobenzene (specific substrate for mammalian Mu class) and trans,trans-deca-2,4-dienal (reactive carbonyl). The canonical activity was considerably reduced by all the conventional inhibitors (cybacron blue, triphenylthin chloride and bromosulfophthalein) and by other inhibitors (ellagic acid, alizarin and chenodeoxycholic acid). Besides this, rEgGST2-3 activity was inhibited by a number of anthelmintic drugs, where the halogenated phenolic drugs (mainly bithionol and hexachlorophene) acted as stronger inhibitors, suggesting they may bind to the EgGST2-3. Moreover, rEgGST2-3 exhibited glutathione-peroxidase activity, and its specific constant (kcat/KM) was calculated. Finally, rEgGST2-3 displayed the ability to bind non-substrate molecules, particularly anthelmintic drugs, suggesting that ligandin activity may have potential to act as a passive protection parasite mechanism. Overall, the rEgGST2-3 behavior was shown to be both complementary and redundant to that reported for rEgGST1, another characterized GST from E. granulosus. It would be appropriate that different enzymes in the same organism do not have exactly the same functional properties to develop a better adaptation to life in the host.</text>
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                <text>&lt;strong&gt;L&amp;oacute;pez, Ver&amp;oacute;nica.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;La Rocca, S.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Arbildi Torres, Paula.&lt;/strong&gt;</text>
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                <text>Acta Tropica&amp;nbsp; v. 180, 2018. -- p. 69-75</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>pontaneous tumors regression has been associated with microbial infection for 100s of years and inspired the use of bacteria for anticancer therapy. Dr. William B. Coley (1862&amp;ndash;1936), a bone- sarcoma surgeon, was a pioneer in treating his patients with both live bacterial-based and mixture of heat-killed bacteria known as &amp;ldquo;Coley&amp;rsquo;s toxins.&amp;rdquo; Unfortunately, Coley was forced to stop his work which interrupted this field for about half a century. Currently, several species of bacteria are being developed against cancer. The bacterial species, their genetic background and their infectious behavior within the tumor microenvironment are thought to be relevant factors in determining their anti-tumor effectiveness in vivo. In this perspective article we will update the most promising results achieved using bacterial therapy (alone or combined with other strategies) in clinically-relevant animal models of cancer and critically discuss the impact of the bacterial variants, route of administration and mechanisms of bacteria-cancer-cell interaction. We will also discuss strategies to apply this information using modern mouse models, molecular biology, genetics and imaging for future bacterial therapy of cancer patients. Back to the Controversial Future The use of microorganisms, in particular live bacteria, for prophylactic vaccination and cancer therapy have been used in humans for long periods in the past and have been a matter of controversy (Payette and Davis, 2001; Hoption Cann et al., 2003). Dr. William B. Coley in the 19th century at the New York Hospital, later to become the Memorial Sloan Kettering Cancer Center (McCarthy, 2006; Hoffman, 2016a), observed and reported spontaneous tumor regression in patients with streptococcal infections (principally erysipelas, known to be caused by Streptococcus pyogenes).</text>
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                <text>Frontiers in Microbiology v.9, 2018. -- 9p.-- e16</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>ANTIOXIDANTES</text>
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                <text>This is the first study to employ a reaction flow (RF) HPLC column of a short 5 cm length to identify antioxidants in a variety of complex samples represented by tea, utilising simultaneous multiplexed detection techniques. The detection responses included: underivatised UV at 280 nm, underivatised fluorescence detection (FLD) and a post column derivatisation (PCD) colorimetric response for antioxidants via the ferric reducing antioxidant power (FRAP) assay. Both similarities and differences in the chromatograms obtained using the three detection modes highlight the power of multiplexed detection. The main findings from the bioactive profiling include: the Fruit of the Forest tea contains the lowest level of antioxidants and is clearly distinct from the other three teas which are based on Camellia sinensis. The antioxidants detected in the green tea and the two black teas are similar. The green tea contains a higher concentration of the two main antioxidants that eluted at 4.0 and 5.7 min. The simplicity of sample analysis and chemical profiling using RF columns and selective detection was the focus of this study via the analysis of antioxidants in tea using the FRAP reagent. The main advantage of RF-PCD is the ability to split flows for simultaneous detection with minimal post column dead volume contributions, making peak matching between detectors much easier. To date, few studies exploit the power of RF-PCD multiplexed detection to differentiate and identify bioactive compounds in various complex samples. Applications of the approach developed in this study may include antioxidant screening and profiling of natural products, foods and beverages.</text>
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                <text>&lt;strong&gt;Jones, Andrew&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Dennis, Gary R.&lt;/strong&gt;</text>
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                <text>Microchemical Journal&amp;nbsp; v. 138, 2018. -- p. 197-202</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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