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                <text>&lt;strong&gt;Cobreado : galvanoplastia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Coca-paste seized samples characterization :&amp;nbsp; Chemical analysis, stimulating effect in rats and relevance of caffeine as a major adulterant&lt;/strong&gt;</text>
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                <text>Coca-paste (CP) is a drug of abuse that so far has not been extensively characterized. CP is an intermediate product of the cocaine alkaloid extraction process from coca leaves, hence it has a high content of cocaine base mixed with other chemical substances (impurities) and it is probably adulterated when it reaches the consumers. Despite its high prevalence and distribution through South America, little is known about its effects on the central nervous system. In the present study, a chemical analysis of CP samples from different police seizures was performed to determine the cocaine base content and the presence and content of impurities and adulterants. Some CP representative samples were selected to study the effects on the locomotor activity induced after acute systemic administration in rats as a measure of its stimulant action. The behavioral response was compared to equivalent doses of cocaine. As expected, cocaine was the main component in most of the CP samples assayed. Caffeine was the only active adulterant detected. Interestingly, several CP samples elicited a higher stimulant effect compared to that observed after cocaine when administered at equivalent doses of cocaine base. Combined treatment of cocaine and caffeine, as surrogate of different CP samples mimicked their stimulant effect. We demonstrated that cocaine and caffeine are the main components responsible for the CP-induced stimulant action while the contribution of the impurities was imperceptible.</text>
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                <text>Behavioural Brain Research v. 221, no. 1, 2011. -- p. 134-141</text>
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                <text>&lt;p&gt;&amp;nbsp;&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Coeficiente t&amp;eacute;rmico de la conductividad de la leche : determinaci&amp;oacute;n en leches de vacas normales de Montevideo&lt;/strong&gt;</text>
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                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;p&gt;Se reportan laws variaciones del colesterol total y del HDL y no HDL colesterol, as&amp;iacute; como el &amp;Iacute;ndice de Castelli, en un estudio transversal realizado en intervalos de tiempo similares en mujeres embarazadas normales. Los datos provenientes de 210 mujeres embarazadas normales en diferentes estadios, se compararon con los de una poblaci&amp;oacute;n de referencia de 30 mujeres normales no gr&amp;aacute;vidas con edades similares. El colesterol HDL fue aislado con &amp;aacute;cido fosfot&amp;uacute;ngstico/cloruro de magnesio, el colesterol se determin&amp;oacute; enzim&amp;aacute;ticamente y el &amp;Iacute;ndice de Castelli as&amp;iacute; como el no HDL colesterol fueron calculados en cada caso. Nuestro objetivo es estudiar los cambios lip&amp;iacute;dicos en esta poblaci&amp;oacute;n de embarazadas con el prop&amp;oacute;sito de establecer los valores de referencia e investigar si la gestaci&amp;oacute;n podr&amp;iacute;a estar relacionada a situaciones de riesgo cardiovascular. El HDL colesterol decreci&amp;oacute; significativamente entre las semanas 24a y 28a, al tiempo que el &amp;Iacute;ndice de Castelli alcanz&amp;oacute; el m&amp;aacute;ximo valor de riesgo. Desde este punto de vista se puede deducir que este proceso puede estar relacionado con el comienzo de la resistencia a la insulina y el mayor riesgo de aparici&amp;oacute;n de diabetes gestacional.&lt;/p&gt;</text>
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                <text>Acta Bioqu&amp;iacute;mica Cl&amp;iacute;nica Latinoamericana v. 29, no. 1, 1995. -- p. 85-91</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The results of computer models for colloidal aggregation, that consider both Brownian motion and gravitational drift experienced by the colloidal particles and clusters, are extended to include concentrations spanning three orders of magnitude. In previous publications and for a high colloidal concentration, it was obtained that the aggregation crosses over from diffusion-limited colloidal aggregation (DLCA) to another regime with a higher cluster fractal dimension and a speeding up followed by a slowing down of the aggregation rate. In the present work we show, as the concentration is decreased, that we can still cross over to a similar regime during the course of the aggregation, as long as the height of the sample is increased accordingly. Among the differences between the mentioned new regimes for a high and a low colloidal concentration, the cluster fractal dimension is higher for the high concentration case and lowers its value as the concentration is decreased, presumably reaching for low enough concentrations a fixed value above the DLCA value. It is also obtained the fractal dimension of the sediments, arising from the settling clusters that reach the bottom and continue a 2D-like diffusive motion and aggregation, on the floor of the container. For these clusters we now see two and sometimes three regimes, depending on concentration and sedimentation strength, with their corresponding fractal dimensions. The first two coming from the crossover already mentioned, that took place in the bulk of the sample before the cluster deposition, while the third arises from the two-dimensional aggregation on the floor of the container. For these bottom clusters we also obtain their dynamical behavior and aggregation rate.</text>
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                <text>The European Physical Journal E v. 13, no. 2, 2004. -- p. 165-178</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Purpose The current research aimed to examine the prevalence of Instagram posts featuring ultra-processed products targeted at adolescents in Uruguay and hence investigate the frequency of such posts among a vulnerable consumer segment in a country that cannot be classified as WEIRD (i.e. Western, educated, industrialized, rich and democratic). Design/methodology/approach The study relied on a cross-sectional content analysis. A total of 2,014 Instagram posts promoting ultraprocessed products or brands commercializing such products, generated by 118 Instagram accounts between August 15th, 2020, and February 15th, 2021, were analyzed. Nine indicators of food marketing targeted at adolescents were selected to identify posts targeted at this age segment. Inductive coding was used to describe the content of the posts. Descriptive statistics and generalized linear models were used to analyze the data. Findings In total, 17.6% of the posts were identified as targeted at adolescents. Graphic design and adolescent language were the most prevalent indicators of marketing targeted at adolescents, followed by explicit references to adolescents or young adults and memes. Posts identified as targeted at adolescents mainly promoted snacks and discretionary foods. Differences in the content of posts identified as targeted and not targeted at adolescents were observed. Research limitations/implications The analysis was restricted to one social media platform in one country during a limited period of time, which limits the generalizability of the findings to other media platforms, samples and settings. Social implications Results stress the need to implement digital food marketing regulations to reduce exposure of adolescents to the deleterious effects of stemming from marketing of unhealthy foods and provide empirical evidence to inform their development. Originality/value The study breaks new ground by analyzing</text>
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                <text>&lt;strong&gt;Ares, Gast�on&lt;/strong&gt;</text>
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&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Echinococcus granulosus is the parasite responsible for cystic echinococcosis (CE), an important worldwide‐distributed zoonosis. New effective vaccines against CE could potentially have great economic and health benefits. Here, we describe an innovative vaccine design scheme starting from an antigenic fraction enriched in tegumental antigens from the protoscolex stage (termed PSEx) already known to induce protection against CE. We first used mass spectrometry to characterize the protein composition of PSEx followed by Gene Ontology analysis to study the potential Biological Processes, Molecular Functions, and Cellular Localizations of the identified proteins. Following, antigenicity predictions and determination of conservancy degree against other organisms were determined. Thus, nine novel proteins were identified as potential vaccine candidates. Furthermore, linear B cell epitopes free of posttranslational modifications were predicted in the whole PSEx proteome through colocalization of in silico predicted epitopes within peptide fragments identified by matrix‐assisted laser desorption/ionization‐TOF/TOF. Resulting peptides were termed &amp;ldquo;clean linear B cell epitopes,&amp;rdquo; and through BLASTp scanning against all nonhelminth proteins, those with 100% identity against any other protein were discarded. Then, the secondary structure was predicted for peptides and their corresponding proteins. Peptides with highly similar secondary structure respect to their parental protein were selected, and those potentially toxic and/or allergenic were discarded. Finally, the selected clean linear B cell epitopes were mapped within their corresponding 3D‐modeled protein to analyze their possible antibody accessibilities, resulting in 14 putative peptide vaccine candidates. We propose nine novel proteins and 14 peptides to be further tested as vaccine candidates against CE.</text>
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                <text>&lt;strong&gt;Miles, Sebasti&amp;aacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Portela, Madel&amp;oacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ancarola, Mar&amp;iacute;a Eugenia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Frischknecht, Friedrich&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=086432105a0be10ef4e4e57df7e51e5a096203688a890b013ec9a12794f41c17f3cd780253064d2d2485395b80b566f9216f3b1d82011d108cd4ea1ac4e03220&amp;amp;formato=pdf&amp;amp;convocatoria=21" target="_self"&gt;&lt;strong&gt;Dematteis, Sylvia&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Journal of Cellular Biochemistry v. 120, 2019. -p. 15320-15336</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Combustion global kinetic analysis of a hydrochar obtained from grape pomace&lt;/strong&gt;</text>
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                <text>2025</text>
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                <text>This research explores the hydrochar production from grape pomace via hydrothermal carbonization and the determination of the kinetic parameters of its combustion process. The hydrochar was obtained by hydrothermal carbonization at 220 ◦C for 240 min with self-generated pressure. The process indicated a mass yield of 65.21 %, and the hydrochar exhibited an HHV of 26.60 MJ/kg, showing its potential as an efficient biofuel. Thermokinetic analysis of hydrochar combustion was conducted using multiple complementary methods: isoconversional analysis, mathematical deconvolution, combined kinetic analysis of each step, and optimization of parameters through nonlinear regression. The findings indicate that the overall process starts at ~152 ◦C and involves three apparent overlapping steps. The apparent activation energies were 165, 122.9, and 185.6 kJ/mol, while the apparent ln</text>
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                <text>Bioresource Technology Reports, v.29, 2025. -- e102038</text>
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&lt;div class="element-text"&gt;
&lt;p&gt;&lt;strong&gt;Información sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;La legislación uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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                <text>Even beer being the most consumed alcoholic beverage around the world, there is not enough information generated for craft beers produced in Latin America, for either volatile profiles or physicochemical studies. In this work, the chemical and volatile components of ten commercial Blond Ale and nine Indian Pale Ale (IPA) beers from the Uruguayan market were studied using GC&amp;ndash;MS. Principal component analysis applied to the data allowed differentiation among the two groups of samples while the volatile compounds and physicochemical parameters responsible for these differences were identified. The physicochemical properties revealed a great diversity between all beer samples even within the same beer style. The main significant differences were ob tained for alcohol, polyphenols, bitterness, colour, and pH. Most Blond Ale beer samples were differentiated from IPA ones by raw fermentation aroma compounds such as 1-pentanol, 1-hexanol, hexanoic and isobutyric acids, 4- vinyl guaiacol, and 5,5-dimethyl-2(5H)-furanone. This is the first work that contributes to the knowledge of Uruguayan craft beers. The study also showed the ability of most of the Uruguayan microbreweries to brew Blond Ale and IPA craft beer styles that meet international standards for physicochemical quality.</text>
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                <text>Con el objetivo de desarrollar potenciales radiofarmacos de 99mTc para imagenes de zonas de hipoxia, se han preparado varios complejos conteniendo el farmac6foro paranitroaromatico. Dicho farmac6foro en condiciones de hipoxia es capaz de sufrir una reducci6n irreversible, transformandose en grupos citot6xicos como el aminobencilo y aminobenceno, que quedarian atrapados dentro de la celula. Como sistema de uni6n del farmac6foro al centro metalico se emplearon los complejos mixtos "3+1" de Tc(V) y los complejos tricarbonilicos de Tc(I). Los complejos mixtos "3+1" fueron preparados empleando cantidades equimoleculares de un ligando tridentado aminoditi61ico y un coligando ti61ico monodentado conteniendo el farmacoforo nitroaromatico. La estructura de estos complejos es del tipo TcO-[(S-(CH2Hs)-NR-(C2Hs)-S + S-R]. EI estudio estructural de los complejos mixtos, realizado empleando los complejos analogos de Re estable, verific6 que en todos los casos se formaron las estructuras esperadas. Los estudios de voltamperometria indicaron que la reducci6n del grupo nitro y el core monooxo ocurre a potenciales que se pueden alcanzar en medios biol6gicos. EI ensayo de citotoxicidad revel6 la importancia de la presencia del grupo dialquilamina en la estructura del ligando tridentado para la citotoxicidad del complejo final. Los complejos de 99mTc fueron preparados por sustituci6n empleando el 99mTc-glucoheptonato como precursor, obteniendo en todos los casos una pureza radioquimica superior al 90%, con una estabilidad de por 10 menos 6 hs. Los estudios de biodistribuci6n en ratones CD1 normales, realizados entre 5 min. y 24 horas post-inyecci6n, mostraron el perfil esperado para compuestos lipofilicos, incluyendo eliminaci6n mayorotaria por via hepatobiliar. La potencialidad para imagenes oncol6gicas fue evaluada en ratones portadores de sarcomas inducidos entre 30 min. y 24 horas post-adm. La captaci6n fue moderada (1.2 %/g a los 30 min.), pero la relaci6n tumor/musculo (TIM) alcanz6 valores entre 1.5 y 2 en el periodo estudiado. Imagenes centellograticas muestran similares resultados. Los complejos tricarbonilicos de 99mTc fueron obtenidos mediante sustituci6n a partir del precursor fac-99mTc-[(COh(H20hr, preparado por reducci6n del pertecneciato en atm6sfera de CO. Para esta etapa se emplearon dos ligandos, uno de los cuales actuaria como tridentado a traves de un sistema donor del tipo NNO EL segundo ligando actuaria como bidentado dejando una posici6n de coordinaci6n libre, este ultimo tam bien se va a emplear conjuntamente con un coligando monodentado adecuado como el CN, para formar un complejo mixto "2+1" tricarbonilico. Para el caso del ligando tridentado se obtuvo una especie con una pureza radioquimica superior al 90%, la que result6 estable por 10 menos 6 hs. Los estudios quimicos permitieron corroborar la formaci6n de la estructura propuesta. Los estudios "in vitro" revelaron que el complejo presenta muy baja citotoxicidad. La voltamperometria muestra que la reducci6n del grupo nitro ocurre a potenciales alcanzables en los medios biol6gicos. Los estudios de biodistribuci6n en animales normales dieron los resultados esperados para un complejo de lipofilicidad intermedia, presentado una eliminaci6n por via hepatobiliar y urinaria y una rapida depuraci6n de sangre y tejidos blandos. Los estudios en animales portadores de tumores revelaron una muy baja captaci6n (0,2%/g a los 30 min.), pero una relaci6n TIM favorable debido a la rapida eliminaci6n. EI complejo tricarbonilico con el ligando bidentado di6 lugar a la formaci6n de varias especies, las cuales pudieron ser restringidas mediante el agregado de un coligando monodentado adecuado como el CN. Los estudios estructurales con Re estable no permitieron la elucidaci6n de la estructura formada pero los datos obtenidos indican la ausencia del grupo nitro en los complejos finales. Los complejos obtenidos no presentaron propiedades 6ptimas para ser utilizados como radiofarmacos de diagn6stico de hipoxia, una de las posibles formas de continuaci6n de este trabajo seria la de realizar la uni6n del mismo farmac6foro al metal a traves de otros sistemas de marcaci6n. Pero dado los resultados similares obtenidos para las estrategias empleadas parece mas adecuado intentar un cambio de farmac6foro para aumentar la selectividad.</text>
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                <text>&lt;strong&gt;Giglio Barossi, Javier&lt;/strong&gt;</text>
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                <text>Facultad de Qu&amp;iacute;mica</text>
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                <text>UdelaR</text>
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                <text>2010</text>
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                <text>&lt;strong&gt;Dra. Rey , Ana(directora de Tesis)&lt;/strong&gt;</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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                <text>&lt;p&gt;&lt;em&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; &lt;/em&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;em&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&lt;/em&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>131p.</text>
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                <text>Espa&amp;ntilde;ol</text>
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                <text>Tesis</text>
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                <text>T.M. 541.28 GIG.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Uruguay</text>
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        <name>Tecnesio</name>
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                  <text>Tesis de doctorado, maestría, trabajos de diploma y monografías técnicas</text>
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                  <text>Versiones electrónicas de las tesis de doctorado, maestría y trabajos de diploma de la Facultad de Química, Universidad de la República (UdelaR).&#13;
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                  <text>Departamento de Documentación y Biblioteca</text>
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                <text>&lt;strong&gt;Comparaci&amp;oacute;n de eficiencias energ&amp;eacute;ticas de ensamblados fotovoltaicos de TiO2 nanoestructurado con diferentes fotosensibilizadores.&lt;/strong&gt;</text>
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            <name>Subject</name>
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                <text>TESIS</text>
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                <text>TESIS DE MAESTRIA</text>
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                <text>&lt;span&gt;ELECTROQUIMICA&lt;/span&gt;</text>
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                <text>&lt;span&gt;CELDAS SOLARES&lt;/span&gt;</text>
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                <text>&lt;span&gt;FOTOSENSIBILIZADORES&lt;/span&gt;</text>
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                <text>&lt;p&gt;En esta Tesis de Doctorado se trabaj&amp;oacute; sobre diferentes fotosensibilizadores para su uso en celdas solares sensibilizadas con pigmentos (DSSC). Estos dispositivos son celdas electroqu&amp;iacute;micas que imitan el proceso natural de fotos&amp;iacute;ntesis, utilizando pigmentos org&amp;aacute;nicos que captan la luz incidente y provocan una separaci&amp;oacute;n de cargas, seguida por un flujo de electrones, representando una forma alternativa de generaci&amp;oacute;n de energ&amp;iacute;a fotovoltaica a bajo costo.&lt;br /&gt;En particular, en este trabajo de investigaci&amp;oacute;n se estudiaron tres pigmentos naturales diferentes: las antocianinas provenientes de la flor del ceibo, la prote&amp;iacute;na ficocianina proveniente del alga Spirulina spp y la prote&amp;iacute;na ficoeritrina proveniente de algas rojas ant&amp;aacute;rticas.&lt;br /&gt;Se llevaron adelante procesos de extracci&amp;oacute;n y purificaci&amp;oacute;n de los pigmentos a trav&amp;eacute;s de cromatograf&amp;iacute;a de exclusi&amp;oacute;n molecular y fase reversa con columnas C18, as&amp;iacute; como tambi&amp;eacute;n su caracterizaci&amp;oacute;n por espectrofotometr&amp;iacute;a UV-visible, espectroscop&amp;iacute;a de fluorescencia, voltamperometr&amp;iacute;a c&amp;iacute;clica y estudios de estabilidad frente a distintos par&amp;aacute;metros. Adem&amp;aacute;s, se realizaron medidas en microbalanza de cuarzo para determinar la adsorci&amp;oacute;n de los pigmentos al semiconductor de la celda.&lt;br /&gt;Por &amp;uacute;ltimo, se armaron celdas con los distintos fotosensibilizadores y en diferentes condiciones, evaluando su funcionamiento a trav&amp;eacute;s de perfiles J vs E y estudios de espectroscop&amp;iacute;a de impedancia electroqu&amp;iacute;mica para determinar par&amp;aacute;metros fotovoltaicos, utilizando un simulador solar.&lt;br /&gt;Destacar que varios de estos estudios fueron posibles gracias a la cooperaci&amp;oacute;n con el Instituto Tecnol&amp;oacute;gico de Chascom&amp;uacute;s (Argentina), el Karlsruher Institute f&amp;uuml;r Technologie (Alemania) y la &amp;Eacute;cole Politechnique F&amp;eacute;d&amp;eacute;rale de Lausanne (Suiza).&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Enciso, Paula&lt;/strong&gt;</text>
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                <text>&lt;span id="docs-internal-guid-8a590489-7fff-8ae8-be85-38c8ba4b6850"&gt;&lt;span&gt;Montevideo : UdelaR-Facultad de Qu&amp;iacute;mica&lt;/span&gt;&lt;/span&gt;</text>
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            <name>Date</name>
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                <text>2020</text>
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                <text>&lt;span&gt;Cerd&amp;aacute;, Mar&amp;iacute;a Fernanda (Directora de Tesis)&lt;/span&gt;</text>
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            <name>Rights</name>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Papel</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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