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                <text>&lt;strong&gt;Lanoline purification by selective extraction of pesticides using suprecritical CO2&lt;/strong&gt;</text>
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                <text>The efficiency of supercritical carbon dioxide for the selective removal of the more important pesticides from commercial lanoline was studied. Lanoline solubility values from 0.03 to 2.50 mg/g CO2 were obtained, corresponding to CO2 densities from 498.4 to 857.3 kg/m3, respectively. The original lanoline showed the following pesticide profile: diazinon 66 ppm, methyl-pirimifos 4.6 ppm and ethion 140 ppm. By an extraction carried out at 25 MPa and 45 &amp;deg;C, using a mass ratio solvent to substrate of 19.5 g CO2/mg lanoline, only 3.4% of lanoline was co-extracted and the pesticide concentrations were reduced to 0.47 ppm for diazinon, less than 20 ppb for methyl-pirimifos and 0.2 ppm for ethion. These results shows that supercritical CO2 is a very convenient solvent for the selective extraction of the main pesticides from lanoline, without the occurrence of substantial lanoline losses during the process.</text>
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                <text>&lt;strong&gt;Margenat, Luc&amp;iacute;a&lt;/strong&gt;</text>
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                <text>Journal of Supercritical Fluids v.45, no. 2, 2008. -- p.177-180</text>
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                <text>DOI: 10.1016/j.supflu.2007.09.034</text>
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                <text>&lt;strong&gt;Urinary tract infection in a South American population : dynamic spread of class 1 integrons and multidrug resistance by homologous and site-specific recombination&lt;/strong&gt;</text>
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                <text>One hundred four bacterial strains mediating urinary tract infections in separate individuals from a Uruguayan community were isolated. Forty-six strains conferred a multidrug resistance phenotype. All 104 strains were examined for the presence of class 1, 2, and 3 integrons. Class 1 integrons were found in 21 isolates across four distinct bacterial genera. A large class 1 integron in a Klebsiella pneumoniae strain was fully sequenced and was 29,093 bp in length. This integron probably arose by homologous recombination since it was embedded in a hybrid Tn21-like transposon backbone which comprised a Tn5036-like tnp transposition module at the IRi integron end and a Tn21 mer module at the IRt integron end. The parent integron/transposon that contributed the Tn5036 module was not related to Tn1696 since the integron insertion points in the transposon backbones were 16 bases apart. Examination of the other 20 class 1 integron-containing strains revealed further evidence of genetic exchange. This included a strain that possessed a Tn5036 module at the IRt end but not at the IRi end and another that possessed a tnp module beyond IRi that was a hybrid of Tn21 and Tn5051 and that is presumed to have arisen by site-specific recombination. This study highlights the ability of different genetic elements to act cooperatively to spread and rearrange antibiotic resistance in a community.</text>
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                <text>&lt;strong&gt;Pentachloro (pyrazine)rhenate(IV) complex as precursors of heterobimetallic pyrazine-containing ReIV 2 MII (M=Ni, Cu) species : synthesis, crystal structure and magnetic properties&lt;/strong&gt;</text>
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                <text>By using [ReCl5(pyz)]&amp;minus; complex as a ligand toward Ni(II) and Cu(II) metal ions, two new Re(IV)-containing compounds have been obtained and magneto-structurally characterized.</text>
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                <text>&lt;strong&gt;Armentano, D.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Cano, Joan&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Faus, Juan&lt;/strong&gt;</text>
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                <text>Dalton Transactions no. 34, 2008. -- p. 4585-4594</text>
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                <text>Royal Society of Chemistry</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="438780">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1039/B802112K</text>
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                  <text>Bibliografía Nacional Química</text>
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              <description>An account of the resource</description>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Mucin-type O-glycosylation in Mesocestoides vogae (syn. corti)&lt;/strong&gt;</text>
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                <text>PARASITOLOGIA</text>
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                <text>Protein glycosylation is an important post-translational modification underlying host&amp;ndash;parasite interactions, which may determine the outcome of infection. Although Mesocestoides vogae represents an important model for investigating the various aspects of cestode biology, virtually no information is available about the structure and synthesis of glycans in this parasite. In this work, focused on the initiation pathway of mucin-type O-glycosylation in M. vogae, we characterized O-glycoproteins bearing the simple mucin-type cancer-associated Tn and sialyl-Tn antigens, and the expression and activity of ppGalNAc-T, the key enzyme responsible for the first step of mucin-type O-glycosylation. Using immunohistochemistry, Tn and sialyl-Tn antigens were detected mainly in the tegument (microtriches) and in parenchymal cells. Tn expression was also observed in lateral nerve cords. Both Tn and sialyl-Tn antigens were detected in in vitro cultured parasites. Based on their electrophoretic mobility, Tn- and sialyl-Tn-bearing glycoproteins from M. vogae were separated into several components of 22 to 60 kDa. The observation that Tn and sialyl-Tn glycoproteins remained in the 0.6 N perchloric acid-soluble fraction suggested that they could be good candidates for characterizing mucin-type glycosylation in this parasite. O-glycoproteins were purified and initially characterized using a proteomic approach. Immunohistochemical analysis of the tissue distribution of ppGalNAc-T revealed that this enzyme is expressed in the sub-tegumental region and in the parenchyma of the parasite. In M. vogae cultured in vitro, ppGalNAc-T was mainly detected in the suckers. Using a panel of 8 acceptor substrate synthetic peptides, we found that M. vogae ppGalNAc-T preferentially glycosylate threonine residues, the best substrates being peptides derived from human mucin MUC1 and from Trypanosoma cruzi mucin. These results suggest that M. vogae might represent a useful model to study O-glycosylation, and provide new research avenues for future studies on the glycopathobiology of helminth parasites.</text>
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                <text>&lt;strong&gt;Medeiros, Andrea&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Chiribao, M. L.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ubillos, Luis.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Festari, M. F.&lt;/strong&gt;</text>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1adf3c6818ae9c0ff60309b22359778f"&gt;&lt;strong&gt;Salda&amp;ntilde;a, Jenny&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Robello, C.&lt;/strong&gt;</text>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=ae579f47d769d2ed742a6a34064041f6"&gt;&lt;strong&gt;Dom&amp;iacute;nguez, Laura&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Calvete, Juan J&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Osinaga, Eduardo.&lt;/strong&gt;</text>
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                <text>International Journal for Parasitology v. 38, no. 3-4, 2008. -- p.265-276</text>
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                <text>Elsevier</text>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="441033">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>&lt;strong&gt;New Ni (II)- sulfonamide complexes : Synthesis, structural characterization and antibacterial properties. X-ray diffraction of [Ni(sulfisoxazole)2(H2o)4].2H2O and [Ni(sulfapyridine)2]&lt;/strong&gt;</text>
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                <text>The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)2(H2O)4] &amp;middot; 2H2O and [Ni(sulfapyridine)2] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)2(H2O)4] &amp;middot; 2H2O crystallized in a monoclinic system, space group C2/c where the nickel ion was in a slightly distorted octahedral environment, coordinated with two sulfisoxazole molecules through the heterocyclic nitrogen and four water molecules. [Ni(sulfapyridine)2] crystallized in a orthorhombic crystal system, space group Pnab. The nickel ion was in a distorted octahedral environment, coordinated by two aryl amine N from two sulfonamides acting as monodentate ligands and four N atoms (two sulfonamidic N and two heterocyclic N) from two different sulfonamide molecules acting as bidentate ligands. Differential pulse voltammograms were recorded showing irreversible peaks at 1040 and 1070 mV, respectively, attributed to Ni(II)/Ni(III) process. [Ni(sulfisoxazole)2(H2O)4] &amp;middot; 2H2O and [Ni(sulfapyridine)2] presented different antibacterial behavior against Staphylococcus aureus and Escherichia coli from the similar copper complexes and they were inactive against Mycobacterium tuberculosis.</text>
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                <text>Journal of Inorganic Biochemistry v. 102, no. 2, 2008. -- p.285-292</text>
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                <text>DOI: 10.1016/j.jinorgbio.2007.09.001</text>
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                <text>Waxes from lime (L) and orange (0) fruits, residues from the citrus industry, were evaluated as possible control methods for Cryptotermes brevis (Walker), the dry-wood termite. This termite is apermanent threat to wooden materials and goods in tropical and subtropical countries. To identify active compounds, orange (0) and lime (L) waxes were partitioned between hexane and methanol. The methanolic extracts of both waxes were further fractionated by vacuum chromatography on silica gel using a polarity gradient of chloroform (01, L1), ethyl acetate (02, L2) and methanol (03, L3). These fractions were "painted" on Pinus sp. blocks. Termite mortality (expressed as % of dead insects) was evaluated over a 60 day period. 01 was active, resulting in an insect mortality of 80% at 45 days. The L2 fraction caused 45% mortality in 28 days The lime wax fraction (L3) resulted in 86% insect mortality at the end of the 60 days. A number of treated wood blocks were stored for 5 months, and exposed to termites after this period. Blocks treated with the O1 fraction were not consumed at all, but 75% of the insects exposed died. The evaluation of the chemical composition of active fractions revealed the presence of oxygenated terpenes and coumarins in O1. Furanocoumarins, flavonoids and limonin, compounds reported as bioactive, were identified in the wax fractions.</text>
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                <text>&lt;strong&gt;Monteiro de Barros, Neiva&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Acosta, Silvana&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mota, Mauricio&lt;/strong&gt;</text>
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                <text>Sociobiology v. 51, no. 1, 2008. -- p. 283-293</text>
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                <text>Universidad Estadual de Feira de Santana</text>
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                <text>In this article a potentiometric method for reducing sugar quantification is described. Copper(II) ion reacts with the reducing sugar (glucose, fructose, and others), and the excess is quantified using a copper wire indicator electrode. In order to accelerate the kinetics of the reaction, working conditions such as pH and temperature must be adjusted. However, a good relationship of mass of reducing sugar to potential was reached. Some of the advantages of the method are its simplicity, low cost, and that can be carried out even in colored and turbid samples. The analysis is safer than the standard Lane&amp;ndash;Eynon method for determination of reducing sugars. To our knowledge, the use of a simple copper wire as electrode has not been reported previously for this type of determination, leading to a simplification of the experimental equipment.</text>
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                <text>&lt;strong&gt;Moresco, Henry&lt;/strong&gt;</text>
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                <text>Journal of Chemical Education v. 85, no.8, 2008. -- p.1091-1093</text>
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                <text>Heterogeneous nucleation and further growth of HgI2 onto glass were studied by the physical vapor deposition (PVD) method, with and without an argon atmosphere. Glass substrates 2&amp;Prime;&amp;times;2&amp;Prime; in area were used for nucleation and growth. Supersaturation strongly determined not only the nuclei population and size, but also the HgI2 nucleation phase. A range of nucleation&amp;ndash;growth temperatures between 303 and 333 K for the substrate, and a range of initial argon pressure between 1.3 and 2.6&amp;times;104 Pa were found appropriate for nucleation and growth in the &amp;alpha; (red) phase of HgI2. Other conditions, such as an argon pressure higher than 4&amp;times;104 Pa, determined the nucleation and growth in the &amp;beta; (yellow) metastable phase. After a nucleation growth time of 30 min, clusters of about 0.5 &amp;mu;m for &amp;beta;-HgI2 and 1 &amp;mu;m for &amp;alpha;-HgI2 and a minimum distance between the clusters of about 1 and 10 &amp;mu;m were, respectively, obtained. Coalescence was performed by annealing the clusters at a temperature between 303 and 333 K and from 5 min to 24 h, at an initial argon pressure of 104 Pa. They coalesced to form larger clusters, which, in the case of the &amp;beta;-phase also transformed to the &amp;alpha;-stable phase. From the experimental nucleation&amp;ndash;growth and further coalescence conditions, correlations between supersaturation conditions and phase were established. Also, considerations about interface free energies and nucleation phase were made. Future work will be conducted to diminish nuclei size and enlarge nuclei population, seeking for early stages of nucleation.</text>
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                <text>&lt;strong&gt;Noguera, Ana L&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Perez, Mar&amp;iacute;a Eugenia&lt;/strong&gt;</text>
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                <text>Journal of Crystal Growth v. 310, no.7-9, 2008. -- p.1691-1696</text>
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                <text>DOI: 10.1016/j.jcrysgro.2007.12.005</text>
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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <elementText elementTextId="709199">
                  <text>Departamento de Documentación y Biblioteca</text>
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                <text>&lt;strong&gt;Estudio de la interacci&amp;oacute;n metal - prote&amp;iacute;nas , un ejercicio experimental de qu&amp;iacute;mica bioinorg&amp;aacute;nica&lt;/strong&gt;</text>
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                <text>QUIMICA BIOINORGANICA</text>
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                <text>METALES</text>
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                <text>PROTEINAS</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b2795d82d8f9cb610b167b6577f861a5" target="_blank"&gt;&lt;strong&gt;Otero Zubiaurre, Ana Luc&amp;iacute;a&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Friet, Eva&lt;/strong&gt;</text>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=5df591c19cc13f11564074d135cd4838"&gt;&lt;strong&gt;Facchin, Gianella&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=617ff0430e37557fbf5f99096500417c"&gt;&lt;strong&gt;Pist&amp;oacute;n, Mariela&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c"&gt;&lt;strong&gt;Gambino, Dinorah&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a title="curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042"&gt;&lt;strong&gt;Torre, Mar&amp;iacute;a H.&lt;/strong&gt;&lt;/a&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Anuario Latinoamericano de Educaci&amp;oacute;n Qu&amp;iacute;mica no. 23, 2007-2008. -- p. 208-214</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="268388">
                <text>Secretar&amp;iacute;a de Ciencia y T&amp;eacute;cnica; Laboratorio de Alternativas Educativas</text>
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                <text>2008</text>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="268390">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>ISSN 0328-087X</text>
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                <text>&lt;strong&gt;Diez experimentos sobre la qu&amp;iacute;mica de los alimentos y la digesti&amp;oacute;n : Una actividad interactiva para ni&amp;ntilde;os de diez a&amp;ntilde;os&lt;/strong&gt;</text>
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                <text>Cyclic voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of novel palladium complexes with bioactive thiosemicarbazones derived from 5-nitrofurane or 5-nitrofurylacroleine. Sixteen palladium complexes grouped in two series of the formula [PdCl2HL] or [PdL2] were studied. ESR spectra of the free radicals obtained by electrolytic reduction were characterized and analyzed. The ESR spectra showed two different hyperfine patterns. The stoichiometry of the complexes does not seem to affect significantly the hyperfine constants however we observed great differences between 5-nitrofurane and 5-nitrofurylacroleine derivatives. The scavenger properties of this family of compounds were lower than Trolox.</text>
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                <text>Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy v. 70A, no. 3, 2008. -- p.519-523</text>
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                <text>We studied the in vitro antitumoral effect of a series of phenazine di-N-oxide derivatives, named 2-chloroacetylamino-7(8)-nitrophenazine N5,N10-dioxide (1), 2-amino-7(8)-(1,3-dioxol-2-yl)phenazine N5,N10-dioxide (2), 2-chloroacetylamino-7(8)-(1,3-dioxol-2-yl)phenazine N5,N10-dioxide (3), and 2-amino-7(8)-methoxyphenazine N5,N10-dioxide (4), on Caco-2 cells. These phenazine N5,N10-dioxide derivatives belong to our in-house chemical library. The products were selected according to their stereoelectronic characteristics and taking into account their differential cytotoxicity against V79 cells. Human colorectal adenocarcinoma cell line Caco-2 was used to study the cell growth inhibition capacity of these compounds, their capacity of altering the cell cycle and possible induction of apoptosis, DNA fragmentation, and genotoxic damage. The IC50 after 24 h of incubation was lower for 1, 2, and 3 (4.8, 46.8, and 8.2 &amp;mu;M, respectively) than for 4 (474.7 &amp;mu;M). Compound 1 induced arrest in the G2/M phase at 24 and 48 h of treatment and apoptosis at the highest doses at 24 h of treatment. These facts were corroborated with caspase 3, caspase 9, and cytochrome c activation and DNA fragmentation at 24 h of treatment. The derivatives studied induced neither significant single strand breaks nor oxidative damage at the different studied times.We concluded that among the series of N5,N10-dioxide phenazine derivatives analyzed, 1, which contains a nitro moiety and a chloroacetamide group, is the most promising as an antitumoral compound.</text>
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                <text>&lt;strong&gt;In silico characterization of cytisinoids docked into an acetylcholine binding protein&lt;/strong&gt;</text>
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                <text>Homology models of nicotinic acetylcholine receptors (nAChRs) suggest that subtype specificity is due to non-conserved residues in the complementary subunit of the ligand-binding pocket. Cytisine and its derivatives generally show a strong preference for heteromeric a4b2* nAChRs over the homomeric a7 subtype, and the structural modifications studied do not cause large changes in their nAChR subtype selectivity. In the present work we docked cytisine, N-methylcytisine, and several pyridone ring-substituted cytisinoids into the crystallographic structure of the Lymnaea stagnalis acetylcholine binding protein (AChBP) co-crystallized with nicotine (1UW6). The graphical analysis of the best poses showed that cytisinoids have weak interactions with the side chains of the non-conserved amino acids in the complementary subunit justifying the use of PDB 1UWB as a surrogate for nAChR. Furthermore, we found a high correlation (R2 = 0.96) between the experimental pIC50 values at a4b2* nAChR and docking energy (S) of the best cytisinoid poses within the AChBP. Due to the quality of the correlation we suggest that this equation might be used as a predictive model to propose new cytisine-derived nAChRs ligands. Our docking results also suggest that further structural modifications of these cytisinoids will not greatly alter their a4b2*/a7 selectivity.</text>
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                <text>&lt;strong&gt;Susan Wonnacott&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Dajas, Federico&lt;/strong&gt;</text>
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                <text>Biorganic and Medicinal Chemistry v. 20, no. 12, 2010. -- 3683-3687</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Aseguramiento de la calidad de los procesos anal&amp;iacute;ticos en la ense&amp;ntilde;anza de la qu&amp;iacute;mica anal&amp;iacute;tica : un ejercicio de laboratorio&lt;/strong&gt;</text>
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                <text>En el presente trabajo se muestra un ejem plo practico de un ejerc icio de laboratorio realizado en el marco del curso de "Aseguramiento de la Cali dad de los Procesos Anal&amp;iacute;ticos". Este curso se dicta para estudiantes de la car rera de Qu&amp;iacute;mico en la Facultad de Qu&amp;iacute;mica de la Univers idad de la Rep&amp;uacute;blica, con el objetivo de capacitar al estudiante para identifi car y estudiar los puntos cr&amp;iacute;t icos en un proceso analltico, establecer los crite rios de validaci&amp;oacute;n de la metodologla anal&amp;iacute;tica y asegurar la ca lidad de los resultados analiticos obtenidos. En el experime nto de laboratorio se valid&amp;oacute; la determin aci &amp;oacute;n de hierro en a limento para pelTOS mediante un m&amp;eacute;todo alternativo al de referencia. Los estudiantes planificaron y llevaron a cabo la validaci&amp;oacute; n del m &amp;eacute;todo alterna tivo. Los resultados obten idos por ambos m&amp;eacute;todos se compararon utilizando pruebas estad &amp;iacute;sticas.</text>
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                <text>&lt;strong&gt;&amp;Aacute;lvarez, Cristina&lt;/strong&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycleframeworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5- nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives.</text>
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                <text>Letters in Drug Design and Discovery v. 7, no. 6, 2010. -- p. 452-460</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Electronic, lipophilic and steric descriptors included in QSAR-2D and -3D are analyzed for a set of ortho- and para-naphthoquinones that have proved to be powerful oxidative agents with potent trypanocidal activities specially against Leptomonas seymouri and Trypanosoma cruzi. Electronic properties are calculated by means of semiempirical (PM3), ab initio (HF/3-21G) and density functional theory (B3LYP/6-31 + G&amp;lowast;) methodologies. Three different electronic states, neutral quinones, hydroquinones and semiquinones, are studied to investigate if any one of them are statistically related with the biological activities. The best correlations were obtained at the B3LYP level of theory because it includes electronic correlation.&lt;br /&gt;&lt;br /&gt;The QSAR-2D indicates that the best trypanocidal growth inhibitors are molecules in the semiquinone electronic state, with the following properties: (a) high negative value of EHOMO, (b) high negative charge in the oxygen atoms of the carbonyl groups, (c) high positive charge in the carbon atom of one of carbonyl moieties and (d) high electronegativity (&amp;chi;). In a complementary way, the QSAR-3D indicates that the electrostatic field correlates with trypanocidal activity and the presence of bulk moieties would increase activity.&lt;br /&gt;&lt;br /&gt;The idea of comparing the three electronic states may prove to be of most importance in the general strategy to the design of new trypanocidal drugs. In fact, the experimental results showed that semiquinone is the one really statistically relevant indicating a clear connection between biochemical and theoretical aspects. Finally, we demonstrated that to be a good anti-trypanosomatid compound, the molecule must be a good electron acceptor to reach easily the essential semiquinone state. We expect that the present results motivate new experimental as well as theoretical investigations that confirm our findings.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>Aim&lt;br /&gt;&lt;br /&gt;We sought to determine variations in fiber organization at the molecular level using x-ray diffraction analyses on human blood vessel specimens after cryopreservation processes.&lt;br /&gt;Materials and Methods&lt;br /&gt;&lt;br /&gt;Diffractometric profiles were performed on aortic and carotid cryopreserved-thawed vessel samples (CVS) versus the same fresh vessel samples (FVS). X-ray diffraction was performed on vascular tissues from 17 cadaveric donors after informed consent. Measurements utilized a Seifert Scintag PAD-II powder diffractometer with CuKa radiation; &amp;lambda; = 1.5418 &amp;Aring;. Scans were evaluated in the 5&amp;deg; to 60&amp;deg; range in theta &amp;minus;2theta mode, in the 5&amp;deg; to 60&amp;deg; range in 2-theta, with steps 0.1&amp;deg; and 10 seconds per step. Ten aortic and 8 carotid diffractometric profiles were analyzed, using differential planimetric surfaces measured under x-ray diffraction curve. Diffractographic profiles were analyzed according to intervals based upon the ages of the donors. An ordering profile coefficient (OPC) was obtained as the quotient between the differential planimetric surface (DPS) of FVS versus CVS vessel ordering diffraction.&lt;br /&gt;Results&lt;br /&gt;&lt;br /&gt;There was a decreased ordering profile according to age: older donors showed less ordering than younger ones. Clear peaks at d-spacing of 2.86 &amp;Aring; and 2.15 &amp;Aring; (2-theta = 31.3&amp;deg; and 42.0&amp;deg;, respectively) were always confirmed despite the different profiles of samples. OPC showed a higher ordering profile among the CVS than FVS: 70% aortas and 62.5% carotids.&lt;br /&gt;Conclusion&lt;br /&gt;&lt;br /&gt;The cryopreserved-thawed procedure does not damage the fibrillar organization of vessels.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>Transplantation Proceedings v. 40, no.3, 2008. -- p. 668-674</text>
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                <text>DOI: 10.1016/j.transproceed.2008.02.025</text>
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                <text>Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically evaluated displaying remarkable in vitro activity against different strains of T. cruzi. Unspecific cytotoxicity was evaluated using mouse macrophages, displaying isothiosemicarbazone 10 and thiosemicarbazone 12 selectivity indexes (macrophage/parasite) of 21 and 27, respectively. In addition, the mode of anti-trypanosomal action of the derivatives was investigated. Some of these derivatives were moderate inhibitors of cysteinyl active site enzymes of T. cruzi, cruzipain and trypanothione reductase. ESR experiments using T. cruzi microsomal fraction suggest that the main mechanism of action of the trypanocidal effects is the production of oxidative stress into the parasite.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1021/jm8006432</text>
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        <name>Enfermedades neurodegenerativas</name>
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