81
25
6754
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https://riquim.fq.edu.uy/files/original/7c6fe3fa944fb3b8ff70c4b0b5fa4977.pdf
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Immobilized peptide-N-glycosidase F onto magnetic nanoparticles: A biotechnological tool for protein deglycosylation under native conditions</strong>
Subject
The topic of the resource
INMOVILIZACION ENZIMATICA
GLICOSILACION
GLICANOS
NANOPARTICULAS
ANALISIS GLICOMICO
BIBLIOGRAFIA NACIONAL QUIMICA
2021
Abstract
A summary of the resource.
<p style="text-align: left;">The elucidation of glycans biological function is essential to<br />understand their role in biological processes, both normal and<br />pathological. Immobilized glycoenzymes are excellent tools for this purpose as they can selectively release glycans from glycoproteins without altering their backbone. They can be easily removed from the reaction mixture avoiding their<br />interference in subsequent experiments. Here, we describe the<br />immobilization of peptide-N-glycosidase F (PNGase F) onto<br />silica magnetic nanoparticles with immobilization yields of<br />86% and activity yields of 12%. Immobilized PNGase F showed<br />higher thermal stability than its soluble counterpart, and could<br />be reused for at least seven deglycosylation cycles. It was<br />efficient in the deglycosylation of several glycoproteins (ribonuclease B, bovine fetuin, and ovalbumin) and a protein lysate from the parasite Fasciola hepatica under nativeconditions, with similar performance to that of the solubleenzyme. Successful deglycosylation was evidenced by adecrease in specific lectin recognition of the glycoproteins (40%–80%). Moreover, deglycosylated F. hepatica lysate allowed us to confirm the role of parasite N-glycans in the inhibition of the lipopolysaccharide-induced maturation of dendritic cells. Immobilized PNGase F probed to be a robust biotechnological tool for deglycosylation of glycoproteins and complex biological samples under native conditions.</p>
Creator
An entity primarily responsible for making the resource
<strong>Bidondo, Lucía.</strong>
<a href="https://exportcvuy.anii.org.uy/pdf/?77af4a993992f329f5b701856972ab56e08e24e02a33bba1512ccdd2f160f02d98c51c8d6f534926795924a5904cfd8a60916df6f7ff8e9857184fa21332a37d" target="_blank"><strong>Festari, Florencia.</strong></a>
<a href="https://exportcvuy.anii.org.uy/cv/?aae0d30077dde60af15f07cae0c9c0586279164eecda795e69661957f9716d393f45e955a03cebaa6f2be7ea3f5dad4539bde28f14864fa8427f6318aecc2637" target="_blank"><strong>Freire, Teresa.</strong></a>
<a href="https://exportcvuy.anii.org.uy/CvEstatico/?urlId=8c80c1ae8b95cb6b8bc4b6ce3a8d3a39b297d1bd27a3804c09be97adcbe35a3741bd28180c0446feac51238afbedb3cf67010e8ed6fa462a13806c083463ea87&formato=pdf&convocatoria=21" target="_blank"><strong>Giacomini, Cecilia.</strong></a>
Source
A related resource from which the described resource is derived
Biotechnology and Applied Biochemistry. -- 2021. -- p. 1-12
Publisher
An entity responsible for making the resource available
Wiley
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
Rights
Information about rights held in and over the resource
<p dir="ltr"><strong>Información sobre Derechos de Autor</strong></p>
<p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p dir="ltr"><strong>La legislación uruguaya protege el derecho de autor</strong><span> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<span id="docs-internal-guid-314533d8-7fff-2a15-1167-20ffe49bbf45"><strong>ADVERTENCIA:</strong><span> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</span></span>
Format
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PDF
Language
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Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
<span> </span>
<div class="epub-section"><a class="epub-doi" href="https://doi.org/10.1002/bab.2099">https://doi.org/10.1002/bab.2099</a></div>
Analisis Glicómico
Glicanos
Glicosilación
Inmovilización enzimática
Nanopartículas
-
https://riquim.fq.edu.uy/files/original/57b97070c260d171e13975a55feebdb3.pdf
b1a506be894f4df1ffbd6129a089b80a
https://riquim.fq.edu.uy/files/original/bff3839719651cc8f48eb3f219a311cd.jpg
8e6cc5bd51365503667c8e8c7938b943
Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
166
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125
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
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PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>A biotechnological tool for glycoprotein desialylation based on immobilized neuraminidase from Clostridium perfringens.</strong>
Subject
The topic of the resource
BIOTECNOLOGIA
GLUCOPROTEINAS
CLOSTRIDIUM
BIBLIOGRAFIA NACIONAL QUIMICA
2021
Abstract
A summary of the resource.
<p>Background: Sialic acids are widely distributed in nature and have biological relevance owing to their varied structural and functional roles. Immobilized neuraminidase can selectively remove terminal N-acetyl neuraminic acid from glycoproteins without altering the protein backbone while it can be easily removed from the reaction mixture avoiding sample contamination. This enables the evaluation of changes in glycoprotein performance upon desialylation.</p>
<p><br />Methods: Neuraminidase was immobilized onto agarose activated with cyanate ester groups and further used for<br />desialylation of model glycoproteins, a lysate from tumour cells and tumour cells. Desialylation process was analysed by lectin binding assay, determination of sialyl-Tn or flow cytometry.</p>
<p><br />Results: Clostridium perfringens neuraminidase was immobilized with 91 % yield and expressed activity yield was<br />of 41%. It was effective in the desialylation of bovine fetal serum fetuin, bovine lactoferrin and ovine submaxilar mucin. A decrease in sialic-specific SNA lectin recognition of 83% and 53 % was observed for fetuin and lactoferrin with a concomitant increase in galactose specific ECA and PNA lectin recognition. Likewise, a decrease in the recognition of a specific antibody (82%) upon mucin desialylation was observed. Moreover, desialylation of aprotein lysate from the sialic acid-rich cell line TA3/Ha was also possible leading to a decrease in 47 % in SNA recognition. Immobilized neuraminidase kept 100% of its initial activity upon five desialylation cycles.</p>
<p>Conclusions: Immobilized neuraminidase is an interesting as well as a robust biotechnological tool for enzymatic<br />desialylation purposes.</p>
<p>General significance: Immobilized neuraminidase would contribute to understand the role of sialic acid in biological processes.</p>
Creator
An entity primarily responsible for making the resource
<strong>Bidondo, Lucía</strong>
<a href="https://exportcvuy.anii.org.uy/cv/?f2d43f458e84ce6d3126f441f7c22d80" target="_blank"><strong>Landeira, Mercedes</strong></a>
<strong>Festari, Florencia</strong>
<a href="https://exportcvuy.anii.org.uy/cv/?aae0d30077dde60af15f07cae0c9c0586279164eecda795e69661957f9716d393f45e955a03cebaa6f2be7ea3f5dad4539bde28f14864fa8427f6318aecc2637" target="_blank"><strong>Freire, Teresa</strong></a>
<a href="https://exportcvuy.anii.org.uy/cv/?8c80c1ae8b95cb6b8bc4b6ce3a8d3a39b297d1bd27a3804c09be97adcbe35a3741bd28180c0446feac51238afbedb3cf67010e8ed6fa462a13806c083463ea87" target="_blank"><strong>Giacomini, Cecilia</strong></a>
Source
A related resource from which the described resource is derived
<span>Biochemistry and Biophysics Reports v. 26, 2021. -- e100940</span>
Publisher
An entity responsible for making the resource available
Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
Rights
Information about rights held in and over the resource
<p dir="ltr"><strong>Información sobre Derechos de Autor</strong></p>
<p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p dir="ltr"><strong>La legislación uruguaya protege el derecho de autor</strong><span> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<span id="docs-internal-guid-3d77981f-7fff-180f-9877-62b134a6cb95"><strong>ADVERTENCIA:</strong><span> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</span></span>
Format
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PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
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<a class="doi" title="Persistent link using digital object identifier" href="https://doi.org/10.1016/j.bbrep.2021.100940" rel="noreferrer noopener" target="_blank">doi.org/10.1016/j.bbrep.2021.100940</a>
Biotecnología
Clostridium
Glucoproteínas
-
https://riquim.fq.edu.uy/files/original/3ef4ea360029cd9c5ff691c0d873b59c.pdf
c845c1000b6329c094a98acfecd6b7ea
https://riquim.fq.edu.uy/files/original/3159c1b7bc3b87d5d32d5905621ebac0.jpg
dac1db3991f8eacd9dfc186e9840ac65
Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
200
Width
155
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Immobilized peptide-N-glycosidase F onto magnetic nanoparticles: a biotechnological tool for protein</strong>
Subject
The topic of the resource
GLICANOS
DESGLICOSILACION
ANALISIS GLICOMICO
INMOVILIZACION ENZIMATICA
NANOPARTICULAS
PEPTIDOS
GLUCOSIDASA
BIBLIOGRAFIA NACIONAL QUIMICA
2022
Abstract
A summary of the resource.
<p>The elucidation of glycans biological function is essential to<br />understand their role in biological processes, both normal and<br />pathological. Immobilized glycoenzymes are excellent tools<br />for this purpose as they can selectively release glycans from<br />glycoproteins without altering their backbone. They can be<br />easily removed from the reaction mixture avoiding their<br />interference in subsequent experiments. Here, we describe the<br />immobilization of peptide-N-glycosidase F (PNGase F) onto<br />silica magnetic nanoparticles with immobilization yields of<br />86% and activity yields of 12%. Immobilized PNGase F showed<br />higher thermal stability than its soluble counterpart, and could<br />be reused for at least seven deglycosylation cycles. It was<br />efficient in the deglycosylation of several glycoproteins<br />(ribonuclease B, bovine fetuin, and ovalbumin) and a protein<br />lysate from the parasite Fasciola hepatica under native<br />conditions, with similar performance to that of the soluble<br />enzyme. Successful deglycosylation was evidenced by a<br />decrease in specific lectin recognition of the glycoproteins<br />(40%–80%). Moreover, deglycosylated F. hepatica lysate<br />allowed us to confirm the role of parasite N-glycans in the<br />inhibition of the lipopolysaccharide-induced maturation of<br />dendritic cells. Immobilized PNGase F probed to be a robust<br />biotechnological tool for deglycosylation of glycoproteins and<br />complex biological samples under native conditions.</p>
Creator
An entity primarily responsible for making the resource
<strong>Bidondo, Lucía</strong>
<strong>Festari, Florencia</strong>
<strong>Freire, Teresa</strong>
<a href="https://exportcvuy.anii.org.uy/cv/?8c80c1ae8b95cb6b8bc4b6ce3a8d3a39b297d1bd27a3804c09be97adcbe35a3741bd28180c0446feac51238afbedb3cf67010e8ed6fa462a13806c083463ea87" target="_blank"><strong>Giacomini, Cecilia</strong></a>
Source
A related resource from which the described resource is derived
Biotechnology and Applied Biochemistry, v. 69, n° 1, 2022. -- pp. 209-220.
Publisher
An entity responsible for making the resource available
Wiley
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Rights
Information about rights held in and over the resource
<p dir="ltr"><strong>Información sobre Derechos de Autor</strong></p>
<p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p dir="ltr"><strong>La legislación uruguaya protege el derechode autor</strong><span> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong><span> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</span></span>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
10.1002/bab.2099
Analisis Glicómico
Desglicosilación
Glicanos
Glucosidasa
Inmovilización enzimática
Nanopartículas
Péptidos
-
https://riquim.fq.edu.uy/files/original/5789ba51b3faca478364002a0198baeb.doc
0f4e6b73dad25df0b61ca80a92a78d89
https://riquim.fq.edu.uy/files/original/0cfe437bb31017b967990ef94a676890.jpg
5413a5435d6b8f3633db6be85012e4ae
Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
160
Width
160
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Serum selenium and glutathione peroxidase activity in critically ill patients with systemic inflammatory response and multiple organ dysfunction syndrome : Preliminary data</strong>
Subject
The topic of the resource
SELENIO
TOXICOLOGIA
LIBROS-ANALITICA
2006
BIBLIOGRAFÍA NACIONAL QUÍMICA
Creator
An entity primarily responsible for making the resource
<strong>Manzanares, William</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1be7431d37af92df16867e8519adf042" target="_blank"><strong>Torre, María H.</strong></a>
<strong>Biestro, A.</strong>
<strong>Pittini, G.</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=eb363e18b4425600161a60511e5af5cf" target="_blank"><strong>Mañay, Nelly</strong></a>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=5df591c19cc13f11564074d135cd4838" target="_blank"><strong>Facchin, Gianella</strong></a>
<strong>Rampoldi, Osvaldo</strong>
Source
A related resource from which the described resource is derived
Metal Ions in Biology and Medicine París: John Libbey Eurotex, 2006 v. 9, 2006. -- p. 535-539
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Libros-Analítica
2006
Bibliografía Nacional Química
Libros-Analítica
Selenio
Toxicología
-
https://riquim.fq.edu.uy/files/original/804a0772387c08779d36999f7a3adce0.pdf
0ebebc2e46cd599f97051dd7aefd7031
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
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3
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397
IPTC Array
a:3:{s:7:"caption";s:72:"no spine minimum. half size. Editor: Paty JEM: Esther
RTP: Cathy Fisher";s:12:"byline_title";s:6:"jcisd8";s:11:"object_name";s:44:"Journal of Chemical Information and Modeling";}
IPTC String
caption:no spine minimum. half size. Editor: Paty JEM: Esther
RTP: Cathy Fisher
byline_title:jcisd8
object_name:Journal of Chemical Information and Modeling
Width
299
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Structures, Properties, and Dynamics of Intermediates in eEF2- Diphthamide Biosynthesis</strong>
Subject
The topic of the resource
PROTEINAS
ENZIMAS
SINTESIS
CELULA EUCARIOTICA
BIBLIOGRAFIA NACIONAL QUIMICA
2016
Abstract
A summary of the resource.
The eukaryotic translation Elongation Factor 2 (eEF2) is an essential enzyme in protein synthesis. eEF2 contains a unique modification of a histidine (His699 in yeast; HIS) into diphthamide (DTA), obtained via 3-amino-3-carboxypropyl (ACP) and diphthine (DTI) intermediates in the biosynthetic pathway. This essential and unique modification is also vulnerable, in that it can be efficiently targeted by NAD+-dependent ADP-ribosylase toxins, such as diphtheria toxin (DT). However, none of the intermediates in the biosynthesis path is equally vulnerable against the toxins. This study aims to address the different susceptibility of DTA and its precursors against bacterial toxins. We have herein undertaken a detailed in silico study of the structural features and dynamic motion of different His699 intermediates along the diphthamide synthesis pathway (HIS, ACP, DTI, DTA). The study points out that DTA forms a strong hydrogen bond with an asparagine which might explain the ADP-ribosylation mechanism caused by the diphtheria toxin (DT). Finally, in silico mutagenesis studies were performed on the DTA modified protein, in order to hamper the formation of such a hydrogen bond. The results indicate that the mutant structure might in fact be less susceptible to attack by DT and thereby behave similarly to DTI in this respect.
Creator
An entity primarily responsible for making the resource
<strong>Billod, Jean Marc</strong>
<strong>Saenz Méndez, Patricia</strong>
<strong>Blomberg, Anders</strong>
<strong>Eriksson, Leif A.</strong>
Source
A related resource from which the described resource is derived
Journal of Chemical Information and Modeling v. 56, 2016. -- p. 1776-1786
Publisher
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ACS
Date
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2016
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong> ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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Artículo
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DOI: 10.1021/acs.jcim.6b00223
Celula eucariotica
Enzimas
Proteínas
Síntesis
-
https://riquim.fq.edu.uy/files/original/6fa61fe000054fc6c4d990218d90024e.pdf
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
Document
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Original Format
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PDF
Dublin Core
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Title
A name given to the resource
<strong>Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents</strong>
Subject
The topic of the resource
ENFERMEDAD DE CHAGAS
ANTICHAGASICOS
BIBLIOGRAFIA NACIONAL QUIMICA
2013
Abstract
A summary of the resource.
As a continuation of our research and with the aim of obtaining new agents against Chagas disease, an extremely neglected disease which threatens 100 million people, eighteen new quinoxaline 1,4-di-N-oxide derivatives have been synthesized following the Beirut reaction. The synthesis of the new derivatives was optimized through the use of a new and more efficient microwave-assisted organic synthetic method. The new derivatives showed excellent in vitro biological activity against Trypanosoma cruzi. Compound 17, which was substituted with fluoro groups at the 6- and 7-positions of the quinoxaline ring, was the most active and selective in the cytotoxicity assay. The electrochemical study showed that the most active compounds, which were substituted by electron-withdrawing groups, possessed a greater ease of reduction of the N-oxide groups.
Creator
An entity primarily responsible for making the resource
<strong>Torres, Enrique</strong>
<strong>Moreno Viguri, Elsa</strong>
<strong>Galiano, Silvia</strong>
<strong>Devarapally, Goutham</strong>
<strong>Crawford, Phillip W.</strong>
<strong>Azqueta, Amaia</strong>
<strong>Arbillaga, Leire</strong>
<strong>Varela, Javier</strong>
<strong>Birriel, Estefanía</strong>
<strong>Di Maio, Rossanna</strong>
<strong>Cerecetto, Hugo</strong>
<strong>González, Mercedes</strong>
<strong>Aldana, Ignacio</strong>
<strong>Monge, Antonio</strong>
<strong>Pérez-Silanes, Silvia</strong>
Source
A related resource from which the described resource is derived
European Journal of Medicinal Chemistry v. 66, 2013. -- p. 324-334
Publisher
An entity responsible for making the resource available
Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
Rights
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<p style="margin-bottom: 0cm;"><strong>Información sobre Derechos de Autor</strong><br /><br />(Por favor lea este aviso antes de abrir los documentos u objetos)<br /><br /><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /><br />(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /><br /><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
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Inglés
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Artículo
Identifier
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https://doi.org/10.1016/j.ejmech.2013.04.065
Antichagásicos
Enfermedad de chagas
-
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>A new series of heteroleptic oxidovanadium(iv) compounds with phenanthroline-derived co-ligands: selective Trypanosoma cruzi growth inhibitors</strong>
Subject
The topic of the resource
ANTIHELMINTICOS
TRIPANOSOMIASIS
ANTITRIPANOSOSMAS
OXIDOVANADIO
BIBLIOGRAFIA NACIONAL QUIMICA
2013
Abstract
A summary of the resource.
Searching for prospective metal-based drugs for the treatment of Chagas disease, a new series of ten mixed-ligand oxidovanadium(IV) complexes, [VIVO(L-2H)(NN)], where L is a tridentate salicylaldehyde semicarbazone derivative (L1–L5) and NN is either 5-amine-1,10-phenanthroline (aminophen) or 5,6-epoxy-5,6-dihydro-1,10-phenanthroline (epoxyphen), were synthesized. The compounds were characterized in the solid state and in solution. EPR spectroscopy suggests that the NN ligands act as bidentate through both nitrogen donor atoms in an axial–equatorial mode. The stability of the complexes in solution was investigated by EPR and 51V-nuclear magnetic resonance spectroscopies. The complexes were evaluated in vitro for their activities against Trypanosoma cruzi (T. cruzi), the parasite responsible for the disease, and their selectivity was analyzed using J-774 murine macrophages, as a mammalian model. All the complexes are more active than both the reference drug Nifurtimox and the previously reported [VIVO(L-2H)(NN)] complexes. In general they are more active than the corresponding free NN ligands. Complexation led to highly increased selectivities towards the parasite. In addition, the lipophilicity of the compounds was determined and correlated with the observed activity in order to perform a QSAR (quantitative structure–activity relationship) study. A clear quadratic correlation is found. This study also confirms the influence of the structure of the co-ligand on the anti-T. cruzi effect. To get insight into the mechanism of action of the compounds, the changes in biochemical pathways promoted by two of the most active and most selective complexes are studied by analyzing a few of the parasite excreted metabolites by 1H NMR spectroscopy. The combined information suggests that the mitochondrion could be a target for these complexes. Furthermore, DNA was preliminarily evaluated as a potential target by using atomic force microscopy (AFM), which showed that the complexes display an ability to interact with this biomolecule.
Creator
An entity primarily responsible for making the resource
<strong>Fernández, Mariana</strong>
<strong>Varela, Javier</strong>
<strong>Correia, Isabel</strong>
<strong>Birriel, Estefania</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=94a8ff70d2730e3c95703f810fd79d7c" target="_blank"><strong>Castiglioni, Jorge</strong></a>
<strong>Moreno, Virtudes</strong>
<strong>Costa Pessoa, Joao</strong>
<strong>Cerecetto, Hugo</strong>
<strong>González, Mercedes</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"><strong>Gambino, Dinorah</strong></a>
Source
A related resource from which the described resource is derived
Dalton Transactions 2013. Disponible Online
Publisher
An entity responsible for making the resource available
Royal Society of Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
<p> </p>
Format
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PDF
Language
A language of the resource
Inglés
Type
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Artículo
Identifier
An unambiguous reference to the resource within a given context
DOI: 10.1039/C3DT50512J
Antihelmínticos
Antitripanosomas
Oxidovanadio
-
https://riquim.fq.edu.uy/files/original/43ab846bb8733d9d54450726b8ea5ba0.pdf
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Dublin Core
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
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Title
A name given to the resource
<p><strong>Los principios fundamentales de la localización industrial y su aplicación en la actividad nacional</strong></p>
Subject
The topic of the resource
INDUSTRIAS
URUGUAY
INDUSTRIA QUÍMICA
1959
BIBLIOGRAFÍA NACIONAL QUÍMICA
Creator
An entity primarily responsible for making the resource
<strong>Bissio, Remo A.</strong>
Source
A related resource from which the described resource is derived
Química Industrial v.5, nº.1, 1959. -- p. 13-27
Química Industrial v 5, nº 2, 1959. -- p. 97-116
Publisher
An entity responsible for making the resource available
Asociación de Ingenieros Químicos (Uruguay)
Date
A point or period of time associated with an event in the lifecycle of the resource
1959
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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Papel
PDF
Language
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Español
Type
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Artículo
Coverage
The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant
Uruguay
1959
Bibliografía Nacional Química
Industria química
Industrias
Uruguay
-
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Los principios fundamentales de la localización industrial y su aplicación en la actividad nacional</strong>
Subject
The topic of the resource
LOCALIZACIÓN INDUSTRIAL
URUGUAY
INDUSTRIA QUÍMICA
1959
BIBLIOGRAFÍA NACIONAL QUÍMICA
Creator
An entity primarily responsible for making the resource
<strong>Bissio, Remo A.</strong>
Source
A related resource from which the described resource is derived
Química Industrial. v.5, .nº1, 1959. -- p. 13-27.
Publisher
An entity responsible for making the resource available
Asociación de Ingenieros Químicos del Uruguay
Date
A point or period of time associated with an event in the lifecycle of the resource
1959
Format
The file format, physical medium, or dimensions of the resource
Papel
PDF
Language
A language of the resource
Español
Type
The nature or genre of the resource
Artículo
1959
Bibliografía Nacional Química
Industria química
Localización industrial
Uruguay
-
https://riquim.fq.edu.uy/files/original/1d468162ac0a752076f8bd3c14430f0f.pdf
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Quatum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase</strong>
Subject
The topic of the resource
QUIMICA CUANTICA
2008
BIBLIOGRAFÍA NACIONAL QUÍMICA
RAYOS X
Creator
An entity primarily responsible for making the resource
<strong>Blakeley, Matthew P.</strong>
<strong>Ruiz, Federico</strong>
<strong>Cachau, Raúl E.</strong>
<strong>Hazemann, Isabelle</strong>
<strong>Meilleur, Flora</strong>
<strong>Mitschler, Andre</strong>
<strong>Ginell, Stephan</strong>
<strong>Afonine, Pavel</strong>
<a title="Currículum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=40f23b501897bd535c01b6602f1ea346" target="_blank"><strong>Ventura, Oscar N.</strong></a>
<strong>Cousido-Siah, Alexandra</strong>
<strong>Haertlein, Andrzej</strong>
<strong>Myles, Dean</strong>
<strong>Podjarny, Alberto</strong>
Source
A related resource from which the described resource is derived
Proceedings of the National Academy of Sciences of the United States of America v. 105, no. 6, 2008. -- p.1844-1848
Publisher
An entity responsible for making the resource available
National Academy of Sciences (United States of America)
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
doi:10.1073/pnas.0711659105
Química cuántica
-
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<p><strong>El uso de la estufa anular de Weisz en la separación y reconocimiento de grupos clásicos de cationes</strong></p>
Subject
The topic of the resource
QUÍMICA ANALÍTICA
CROMATOGRAFIA
1963
BIBLIOGRAFÍA NACIONAL QUÍMICA
ESTUFA ANULAR DE WEISZ
CATIONES
Creator
An entity primarily responsible for making the resource
<strong>Blanco de Lema, F.</strong>
Source
A related resource from which the described resource is derived
COR : Comunicaciones Originales Cortas y Resúmenes v. 1, nº 4, 1963. -- p. 313-315 com. 184
Publisher
An entity responsible for making the resource available
Asociación de Estudiantes de Química (Uruguay)
Date
A point or period of time associated with an event in the lifecycle of the resource
1963
Rights
Information about rights held in and over the resource
<h3>Derechos</h3>
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho de autor</strong> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
Papel
PDF
Language
A language of the resource
Español
Type
The nature or genre of the resource
Artículo
1963
Bibliografía Nacional Química
Cationes
Cromatografía
Estufa anular de Weisz
Química analítica
-
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Consideraciones sobre el significado de algunas constantes fisicoquímicas.<br /></strong>
Subject
The topic of the resource
QUIMICA FISICA
CONSTANTES FISICOQUIMICAS
URUGUAY
BIBLIOGRAFIA NACIONAL QUIMICA
1997
Creator
An entity primarily responsible for making the resource
<strong>Blanco, S</strong>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6586904caf76687142b8c1917494e201"><strong> Grompone, María Antonia</strong></a>
<strong>García, Marisa</strong>
<strong>Ferretti, F</strong>
Source
A related resource from which the described resource is derived
Información Tecnológica v. 8, no. 3, 1997
Publisher
An entity responsible for making the resource available
CIT
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Español
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
http://dx.doi.org/10.4067/S0718-07642008000600001
Constantes físicas
Química Física
Uruguay
-
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Pirolisis de la madera y sus posibilidades</strong>
Subject
The topic of the resource
CARBONIZACIÓN DE LA MADERA
PIROLISIS DE LA MADERA
1992
BIBLIOGRAFÍA NACIONAL QUÍMICA
URUGUAY
Creator
An entity primarily responsible for making the resource
<strong>Salchi, Carlos</strong>
<strong>Blasina, Gonzalo</strong>
<strong>Morales, Enrique</strong>
Source
A related resource from which the described resource is derived
Ingeniería Química. nº3, 1992. -- p. 20-23
Publisher
An entity responsible for making the resource available
Asociación de Ingenieros Químicos del Uruguay
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
Papel
PDF
Language
A language of the resource
Español
Type
The nature or genre of the resource
Artículo
1992
Bibliografía Nacional Química
Carbonización de la madera
Pirolisis de la madera
-
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
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205
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Farmacia galénica : los agentes terapéuticos coloidales<br /></strong>
Subject
The topic of the resource
FARMACIA
FARMACIA GALÉNICA
COLOIDES
1917
BIBLIOGRAFÍA NACIONAL QUÍMICA
Creator
An entity primarily responsible for making the resource
<strong>Bocage, A.</strong>
Source
A related resource from which the described resource is derived
Ph :Órgano Oficial de la Asociación de Estudiantes de Química Uruguay. v.2, nº 5-6, 1917. -- p. 136-154.
Publisher
An entity responsible for making the resource available
Asociación de Estudiantes de Química (Uruguay)
Date
A point or period of time associated with an event in the lifecycle of the resource
1917
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
Papel
PDF
Language
A language of the resource
Español
Type
The nature or genre of the resource
Artículo
1917
Bibliografía Nacional Química
Coloides
Farmacia
Farmacia galénica
-
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Farmacia galénica: los agentes terapéuticos coloidales</strong>
Subject
The topic of the resource
FARMACIA GALÉNICA
FARMACIA
AGENTES TERAPÉUTICOS COLOIDALES
1917
BIBLIOGRAFÍA NACIONAL QUÍMICA
Creator
An entity primarily responsible for making the resource
<strong>Bocage, A.</strong>
Source
A related resource from which the described resource is derived
Ph :Órgano Oficial de la Asociación de Estudiantes de Química Uruguay. v. 2 .nº 5-6 , 1917. -- p. 136-154
Publisher
An entity responsible for making the resource available
Asociación de Estudiantes de Química (Uruguay)
Date
A point or period of time associated with an event in the lifecycle of the resource
1917
Format
The file format, physical medium, or dimensions of the resource
Papel
PDF
Language
A language of the resource
Espeñol
Type
The nature or genre of the resource
Artículo
1917
Agentes terapéuticos
Bibliografía Nacional Química
Coloides
Farmacia
Química
-
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Historia de la Facultad de Química y materiales históricos
Description
An account of the resource
Historia de la Facultad de Química desde 1908 hasta la fecha y diversos materiales de carácter histórico.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Proyecto de la creación de la Facultad de Farmacia y Química: presentado al Consejo de la Facultad de Medicina por los Consejeros Señores: Armando Bocage y Francisco V. della Croce.</strong>
Subject
The topic of the resource
CREACIÓN FACULTAD DE QUÍMICA
MONTEVIDEO
URUGUAY
HISTORIA DE LA FACULTAD DE QUÍMICA
Creator
An entity primarily responsible for making the resource
<strong>Bocage, Armando</strong>
<strong>Della Croce, Francisco V.</strong>
Source
A related resource from which the described resource is derived
En: Asociación de Farmacia y Química del Uruguay:bosquejo histórico de las gestiones pro-creación Facultad de Química y Farmacia. nov., 1929. -- p.39-46.
Publisher
An entity responsible for making the resource available
Asociación de Farmacia y Química del Uruguay
Date
A point or period of time associated with an event in the lifecycle of the resource
1929
Rights
Information about rights held in and over the resource
<p align="LEFT"><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p style="margin-bottom: 0cm;"><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
Papel
PDF
Language
A language of the resource
Español
Type
The nature or genre of the resource
Material Histórico
Coverage
The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant
Uruguay
Creación de la Facultad de Químiica
-
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Contenido y composición lipídica de carnes bovinas uruguayas provenientes de diferentes cruzamientos</strong>
Subject
The topic of the resource
CARNE DE VACUNO
COMPOSICION LIPIDICA
URUGUAY
2002
BIBLIOGRAFÍA NACIONAL QUÍMICA
Creator
An entity primarily responsible for making the resource
<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6586904caf76687142b8c1917494e201" target="_blank"><strong>Grompone, María Antonia</strong></a>
<strong>Pagano, T.</strong>
<strong>Harispe, R.</strong>
<strong>Miños, A.</strong>
<strong>Bodmer, L.</strong>
<strong>Aguilar, I.</strong>
<strong>Gimeno, D.</strong>
Source
A related resource from which the described resource is derived
Carnes y Alimentos (Uruguay) v. 3, no. 6, 2002. -- p. 5-9
Publisher
An entity responsible for making the resource available
Hemisferio Sur SRL
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong><br /> <br /> (Por favor lea este aviso antes de abrir los documentos u objetos)<br /> <br /> <strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /> <br /> (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /> <br /> <strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
The file format, physical medium, or dimensions of the resource
PDF
Language
A language of the resource
Español
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
ISSN 1510-3870
Carne de vacuno
Composición química
Uruguay
-
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The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene</strong>
Subject
The topic of the resource
ANTITRIPANOSOMA
TRYPANOSOMA CRUZI
BIBLIOGRAFIA NACIONAL QUÍMICA
ENFERMEDAD DE CHAGAS
NITROFURANOS
2009
Abstract
A summary of the resource.
Chagas disease represents a serious public health problem in South America. The first line of treatment is Nifurtimox and Benznidazole which generate toxic effects in treated patients. We have recently shown that a number of 5-nitrofuranes possess activity against Trypanosoma cruzi through oxidative stress and inhibition of parasite ergosterol biosynthesis, specifically at the level of squalene epoxidase. Here, we identify new 5-nitrofuranes and the thia-analogues with excellent effects on the viability of T. cruzi and adequate parasite/mammal selectivity indexes. Analysis of the free sterols from parasite incubated, during 120 h, with the compounds showed that some of them accumulated squalene suggesting the squalene epoxidase activity inhibition of the parasite. Nifurtimox was able to accumulate squalene only at lower incubation times. Due to this fact some derivatives were also tested as antifungal agents. Quantitative structure–activity relationship studies were also performed showing relevant features for further new derivatives design. Taken together, the results obtained in the present work point to a more general effect of 5-nitrofuranes and 5-nitrothiophenes in trypanosomatids, opening potential therapeutic possibilities of them for these infectious diseases.
Creator
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<strong>Gerpe, Alejandra</strong>
<strong>Alvarez, Guzman</strong>
<strong>Benítez, Diego</strong>
<strong>Boiani Santurio, Lucía</strong>
<strong>Quiroga, Martín</strong>
<strong>Hernández, Paola</strong>
<strong>Sortino, Maximiliano</strong>
<strong>Zacchino, Susana</strong>
<strong>González Hormaizteguy, Mercedes</strong>
<strong>Cerecetto, Hugo</strong>
Source
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Bioorganic & Medicinal Chemistry v. 17, no. 21, 2009. -- p.7500-7509
Publisher
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Elsevier
Date
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2009
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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doi:10.1016/j.bmc.2009.09.013
Antitripanosomas
Enfermedad de chagas
Nitrofuranos
Trypanosoma cruzi
-
https://riquim.fq.edu.uy/files/original/6d0c6451448968634df6bc9e9e3f3bb4.pdf
e178036d9674f251826713e8851bbff2
https://riquim.fq.edu.uy/files/original/44801ecb572959d0a8cd07e50e0c0f3c.bmp
5c4d4bc37de2164e0eef4182be646832
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Title
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Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
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Title
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<strong>Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi : is oxidative stress involved?</strong>
Subject
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TRIPANOSOMIASIS
ENFERMEDAD DE CHAGAS
NIFURTIMOX
TRIPANOSOMA CRUZI
ESTRES OXIDATIVO
BIBLIOGRAFIA NACIONAL QUIMICA
2010
Abstract
A summary of the resource.
Chagas disease is caused by the trypanosomatid parasite Trypanosoma cruzi and threatens millions of lives in South America. As other neglected diseases there is almost no research and development effort by the pharmaceutical industry and the treatment relies on two drugs, Nifurtimox and Benznidazole, discovered empirically more than three decades ago. Nifurtimox, a nitrofurane derivative, is believed to exert its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen. This hypothesis is generally accepted, although arguments against it have been presented. In the present work we studied the ability of Nifurtimox and five N-oxide-containing heterocycles to induce oxidative stress in T. cruzi. N-Oxide-containing heterocycles represent a promising group of new trypanosomicidal agents and their mode of action is not completely elucidated. The results here obtained argue against the oxidative stress hypothesis almost for all the studied compounds, including Nifurtimox. A significant reduction in the level of parasitic low-molecular-weight thiols was observed after Nifurtimox treatment; however, it was not linked to the production of reactive oxidant species. Besides, redox-cycling is only observed at high Nifurtimox concentrations (>400 mM), two orders ofmagnitude higher than the concentration required for anti-proliferative activity (5 mM). Our results indicate that an increase in oxidative stress is not the main mechanism of action of Nifurtimox. Among the studied N-oxide-containing heterocycles, benzofuroxan derivatives strongly inhibited parasite dehydrogenase activity and affected mitochondrial membrane potential. The indazole derivative raised intracellular oxidants production, but it was the least effective as anti-T. cruzi.
Creator
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<strong>Boiani Santurio, Mariana</strong>
<strong>Piacenza, Lucía</strong>
<strong>Hernández, Paola</strong>
<strong>Boiani Santurio, Lucía</strong>
<strong>Cerecetto, Hugo</strong>
<strong>González, Mercedes</strong>
<strong>Denicola Creci, Ana Beatriz</strong>
Source
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Biochemical Pharmacology v. 79, no. 12, 2010. -- p.1736 - 1745
Publisher
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Elsevier
Date
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2010
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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Artículo
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doi:10.1016/j.bcp.2010.02.009
Enfermedad de chagas
Estres Oxidativo
Nifurtimox
Tripanosomiasis
Trypanosoma cruzi
-
https://riquim.fq.edu.uy/files/original/81bc6d47113d24221f6187f0857a3aa9.pdf
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Title
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Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
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Title
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<strong>Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth : synthesis, biological evaluation, and structure–activity relationships</strong>
Subject
The topic of the resource
COMPUESTOS HETEROCICLICOS
CITOTOXICIDAD
TRYPANOSOMA CRUZI
BIBLIOGRAFIA NACIONAL QUIMICA
2007
Abstract
A summary of the resource.
In vitro growth inhibitory activity of 21 new 5-ethenylbenzofuroxan derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, was studied. The designed compounds possess the previously described exigencies for optimal anti-parasite activity, the 5-ethenylbenzofuroxanyl moiety with different substituents. The synthetic key for preparing the derivatives was the Wittig procedure, that when 5-formylbenzofuroxan was used as the electrophile the corresponding deoxygenated products were marginally generated. Four of the new derivatives displayed remarkable in vitro activities against the epimastigote form of three strains of T. cruzi, Tulahuen 2, CL Brener, and Y. While the three deoxygenated analogues biologically assayed resulted inactives. Unspecific cytotoxicity was evaluated using human macrophages and active derivatives were not toxic at a concentration at least 13 times that of its IC50 against T. cruzi (CL Brener strain). From the preliminary structure–activity relationship studies lipophilicity and electronic requirements were found relevant to anti-T. cruzi activity. Active compounds are more lipophilic than inactive ones and it was also identified that an optimum value of R Swain-Lupton’s descriptor is required for optimal activity
Creator
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<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=01ded1b48a793797e49a8cb9b67aecea"><strong>Porcal, Williams</strong></a>
<strong>Hernández, Paola</strong>
<strong>Aguirre, G</strong>
<strong>Boiani Santurio, Lucía</strong>
<strong>Boiani Santurio, Mariana</strong>
<strong>Merlino, Alicia</strong>
<strong>Ferreira, A.</strong>
<strong>Castro, A.</strong>
<strong>González, Mercedes.</strong>
<strong>Cerecetto, Hugo</strong>
Rights
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<p><strong>Información sobre Derechos de Autor</strong><br /><br />(Por favor lea este aviso antes de abrir los documentos u objetos)<br /><br /><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes<br /><br />(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /><br /><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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<a title="Artículo" href="https://doi.org/10.1016/j.bmc.2007.01.009" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.bmc.2007.01.009</a>
Citotoxicidad
Compuestod Heterociclicos
Trypanosoma cruzi
-
https://riquim.fq.edu.uy/files/original/0b645dbeda22035da276a7815280d79f.pdf
e178036d9674f251826713e8851bbff2
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
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<strong>Imidazole and benzimidazole derivatives as chemotherapeutic agents.</strong>
Subject
The topic of the resource
IMIDAZOL
BENZIMIDAZOL
ANTIHELMINTICOS
ANTIBACTERIANOS
TERAPIA CON MEDICAMENTOS
BIBLIOGRAFIA NACIONAL QUIMICA
2005
Abstract
A summary of the resource.
Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.
Creator
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<strong>Boiani Santurio, Mariana</strong>
<strong>González, Mercedes</strong>
Source
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Mini Reviews in Medicinal Chemistry v. 5, no. 4, 2005. -- p. 409-424
Publisher
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Bentham
Date
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2005
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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Inglés
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Artículo
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DOI: 1389-5575/05
Antibacterianos
Antihelmeticos
Benzimidazol
Imidazol
Terapia con medicamentos
-
https://riquim.fq.edu.uy/files/original/6276f77f0d7cf0c94dc92dfdd7c95bd9.pdf
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
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If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
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<strong>Cytotoxicity of furoxans : quantitative structure activity relationship study.</strong>
Subject
The topic of the resource
FUROXANOS
CITOTOXICIDAD
BIBLIOGRAFIA NACIONAL QUIMICA
2004
Abstract
A summary of the resource.
Furoxans are interesting biological active compounds. Recent studies demonstrate that they are cytotoxic under aerobic conditions. This paper shows that this cytotoxicity could be related with ELUMO, calculated LogP and Mulliken charge on heterocycle nitrogen 2 calculated at ab initio level (3-21G* basis). It was possible to propose a tentative mechanism of cytotoxicity and structural modifications to modulate the cytotoxic potency of furoxan derivatives.
Creator
An entity primarily responsible for making the resource
<strong>Boiani Santurio, Mariana</strong>
<strong>Cerecetto, Hugo.</strong>
<strong>González, Mercedes.</strong>
Source
A related resource from which the described resource is derived
IL Farmaco v. 59, no. 5, 2004. -- p. 405-412
Publisher
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Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
<p> </p>
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PDF
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Artículo
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doi:10.1016/j.farmac.2003.12.011
Citotoxicidad
Furoxanos
-
https://riquim.fq.edu.uy/files/original/2536871e007bba86fc26dd42925dd4d6.pdf
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Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
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Title
A name given to the resource
<strong>Tautomerism and reactivity in heterocyclic N-Oxides. A spectrocopic and theoretical study of benzimidazole N-Oxide derivatives (N-Hydroxybenzimidazoles.</strong>
Subject
The topic of the resource
BENZIMIDAZOL
BIBLIOGRAFIA NACIONAL QUIMICA
2004
Abstract
A summary of the resource.
The tautomeric forms of benzimidazole N-oxide derivatives in solution were studied using nuclear magnetic resonance (NMR) techniques. Further insight into the molecular structures was provided by theoretical calculations using density functional theory (DFT). In the gas phase the N-hydroxy tautomer was more stable than the N-oxide, whereas in solution the stabilization of one form or the other depended on hydrogen bond formation involving the N-hydroxy/N-oxide moiety. Derivative 4 (n-butyl-5-nitrobenzimidazole-2-carboxamide 3-oxide), having a 2-carboxamide moiety, was the only compound studied present as a mixture of tautomers, the N-oxide being the predominant one. This was assigned to the formation of an internal hydrogen bond between the N-oxide group and the amide hydrogen atom. The tautomeric form present in the solid state was studied for derivative 1 (ethyl-5-nitrobenzimidazole-2-carboxylate 3-oxide) and was conclusively assigned by X-ray diffraction techniques to the N-hydroxy tautomer. In the crystal a strong O-HâââN intermolecular bond gives rise to supramolecular polymeric chains in the lattice. This strong interaction was also seen in the infrared spectrum and was assigned to two broad bands at 2367 and 2526 cm-1. The vibrational spectrum was satisfactorily described by DFT calculations and an example of this is the prediction of the band corresponding to the N-O stretching (N-oxide) just 1% lower than the experimental value. Uncorrelated calculations (HF) were not able to give an unambiguous assignment of this band. The reaction of derivative 1 against different kinds of electrophiles, hard and soft, led only to O-substituted products. This result was explained in terms of the HSAB theory using a local-global approach.
Creator
An entity primarily responsible for making the resource
<strong>Boiani Santurio, Mariana</strong>
<strong>Cerecetto, Hugo</strong>
<strong>González, Mercedes.</strong>
<strong>Piro, Oscar E</strong>
<strong>Castellano, Eduardo E</strong>
Source
A related resource from which the described resource is derived
Journal of Physical Chemistry A v. 108, no. 51, 2004. -- p. 11241-11248
Publisher
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American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
<p> </p>
Format
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PDF
Language
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Inglés
Type
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Artículo
Identifier
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DOI: 10.1021/jp046826v
Benzimidazol
-
https://riquim.fq.edu.uy/files/original/fb2a21f9101e3998ab29c2ec08e8774d.pdf
4ade9939a72776b294e83f5ca8fe03c5
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Omeka Image File
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Bit Depth
8
Channels
3
Height
161
Width
115
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
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Title
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<strong>Uso de modelado molecular como herramienta didáctica en el primer curso de grado de química orgánica.</strong>
Subject
The topic of the resource
QUIMICA ORGANICA
BIBLIOGRAFIA NACIONAL QUIMICA
2004
Abstract
A summary of the resource.
The application of diagnostic evaluations in advanced courses of organic chemistry revealed a poor learning of some concepts presented in previous organic chemistry courses. Taking this into consideration and aiming at overcoming these difficulties, a new aula methodology was implanted in the first organic chemistry course. By using molecular modeling as a didactic tool our objective was to improve the student’s ability to visualize the tridimensional structure of molecules and correlate it with their reactivity. Also, the use of this interactive graphical methodology allows the students to solve problems (and not only simple exercises) and increases their capacity at interdisciplinary thinking. In addition, the students are exposed to new techniques used in current research in organic chemistry. This methodology was implanted in a so called ‘‘virtual laboratory’’. This experience was evaluated as very good. It is worth to mention the high receptivity and enhanced motivation found in the participants related to the didactic tool used, which offered a visual aid to facilitate the learning of different topics in the course.
Creator
An entity primarily responsible for making the resource
<strong>Boiani Santurio, Mariana</strong>
<strong>Buccino, P</strong>
<strong>Cerecetto, Hugo</strong>
<strong>González, Mercedes.</strong>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8abd84ccbe579b144b1677ae3d4f1405"><strong>Lopez, Gloria V</strong></a>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=f4e5f5966e2f949cc6ad308da8978be6"><strong>Sáenz, Patricia</strong></a>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=502f70a0642a910f5abf0e0d5c853b61"><strong>Seoane, Gustavo</strong></a>
<strong>Loureiro, S</strong>
<strong>Miguez, M</strong>
<strong>Otegui, X</strong>
Source
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Educación Química v. 15, no. (Extraordin), 2004. -- p. 349-352
Publisher
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Universidad Nacional Autónoma de México
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
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Español
Type
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Artículo
Identifier
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ISSN: 0187-893X
Química orgánica
-
https://riquim.fq.edu.uy/files/original/23263c1d97fbe339114d3a7ccb31f55e.pdf
e178036d9674f251826713e8851bbff2
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
150
Width
113
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
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Title
A name given to the resource
<strong>1,2,5 Oxadiazole N-oxide derivatives as potential anti-cancer agents : synthesis and biological evaluation. Part IV.</strong>
Subject
The topic of the resource
ANTINEOPLASICOS
SINTESIS
EVALUACION BIOLOGICA
BIBLIOGRAFIA NACIONAL QUIMICA
2001
Abstract
A summary of the resource.
Several new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds prepared were designed in order to gain insight into the mechanism of action of this kind of cytotoxin. Compounds were tested in oxia and hypoxia and they proved to be non-selective. 3-Cyano-N2-oxide-4-phenyl-1,2,5-oxadiazole showed the best cytotoxic activity in oxia. The cytotoxicity observed for these derivatives could be explained in terms of the electronic characteristics of the 1,2,5-oxadiazole substituents. Electrochemical and ESR studies were performed on the more cytotoxic derivative.
Creator
An entity primarily responsible for making the resource
<strong>Boiani Santurio, Mariana</strong>
<strong>Cerecetto, Hugo</strong>
<strong>González, Mercedes</strong>
<strong>Risso Lavignasse, Mariela</strong>
<strong>Olea-Azar, C</strong>
<strong>Piro, O. E</strong>
<strong>Castellano, E. E</strong>
<strong>López de Cerain, A</strong>
<strong>Ezpeleta, O</strong>
<strong>Monge-Vega, A</strong>
Source
A related resource from which the described resource is derived
European Journal of Medicinal Chemistry v. 36, no. 10, 2001. -- p. 771-82
Publisher
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Elsevier
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Language
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Inglés
Type
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Artículo
Identifier
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doi:10.1016/S0223-5234(01)01265-X
Antineoplásicos
Evaluación biológica
Síntesis