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                  <text>Tesis de doctorado, maestría, trabajos de diploma y monografías técnicas</text>
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                  <text>Versiones electrónicas de las tesis de doctorado, maestría y trabajos de diploma de la Facultad de Química, Universidad de la República (UdelaR).&#13;
Incluye únicamente trabajos hasta el año 2023. Los trabajos posteriores se encuentran disponibles en el Repositorio Colibrí.</text>
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                <text>&lt;strong&gt;Estudio de reacciones bio-ortogonales con aplicaci&amp;oacute;n en el diagn&amp;oacute;stico de c&amp;aacute;ncer&lt;/strong&gt;</text>
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                <text>Desde el punto de vista de los trazadores nuestro grupo de investigaci&amp;oacute;n va a centrar su atenci&amp;oacute;n en el dise&amp;ntilde;o, s&amp;iacute;ntesis, evaluaci&amp;oacute;n y aplicaci&amp;oacute;n cl&amp;iacute;nica de diversos trazadores, destacando las siguientes l&amp;iacute;neas de investigaci&amp;oacute;n: 1.1. Aplicaciones oncol&amp;oacute;gicas de la Indocianina Verde (ICG) y 99mTc- nanocoloide-ICG: Dadas las propiedades de fluorescencia en el infrarrojo cercano de la ICG asociado a su biodistribuci&amp;oacute;n permite ser empleado para detecci&amp;oacute;n de met&amp;aacute;stasis hep&amp;aacute;tica de c&amp;aacute;ncer de colon, hepatocarcinomas, fuga biliar, evaluaci&amp;oacute;n de perfusi&amp;oacute;n de tejidos entre otras. Asimismo su combinaci&amp;oacute;n con 99mTc nanocoloide permite ser empleada como trazador hibrido (radioactivo y fluorescente) en procedimientos de ganglio centinela. Se plantea introducir estos trazadores en el intraoperatorio, guiando a los cirujanos para realizar cirug&amp;iacute;as m&amp;aacute;s exitosas. 1.2. Anticuerpos monoclonales y p&amp;eacute;ptidos(R-F-H) como agentes de diagn&amp;oacute;stico oncol&amp;oacute;gico: Dado que no existen trazadores oncoespec&amp;iacute;ficos de mieloma m&amp;uacute;ltiple, linfoma no Hodgkin y melanoma, nos planteamos emplear anticuerpos monoclonales (tocilizumab, rituximab) y p&amp;eacute;ptidos (alfa-MSH) R, F e H para ser empleados en la evaluaci&amp;oacute;n de dichas patolog&amp;iacute;as. El marcado fluorescente podr&amp;iacute;a guiar la toma biopsica. 1.3. Nano veh&amp;iacute;culos: dendr&amp;iacute;meros y liposomas radioactivos fluorescentes h&amp;iacute;bridos como agentes de diagn&amp;oacute;stico oncol&amp;oacute;gico: Esta l&amp;iacute;nea de investigaci&amp;oacute;n busca una aplicaci&amp;oacute;n en el diagn&amp;oacute;stico y eventual tratamiento oncol&amp;oacute;gi</text>
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                <text>&lt;strong&gt;Garcia, Mar&amp;iacute;a Fernanda&lt;/strong&gt;</text>
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                <text>Montevideo: UdelaR-Facultad de Quimica</text>
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                <text>&lt;strong&gt;Cabral, Pablo (director de Tesis)&lt;/strong&gt;</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <name>Channels</name>
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          <name>Original Format</name>
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                <text>Biblioteca-FQ</text>
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            <description>A language of the resource</description>
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                <text>Ingl&amp;eacute;s</text>
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            <description>The nature or genre of the resource</description>
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      <description>A resource containing textual data.  Note that facsimiles or images of texts are still of the genre text.</description>
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          <description>If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data</description>
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            <description>A name given to the resource</description>
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            <description>The topic of the resource</description>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
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                <text>Biblioteca-FQ</text>
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            <name>Date</name>
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            <description>The file format, physical medium, or dimensions of the resource</description>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>Ingl&amp;eacute;s</text>
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            <description>The nature or genre of the resource</description>
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            <description>A name given to the resource</description>
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                <text>&lt;strong&gt;L&amp;aacute;minas para impresi&amp;oacute;n offset&lt;/strong&gt;</text>
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            <description>The topic of the resource</description>
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                <text>Biblioteca-FQ</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor &lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Feromonas de lepid&amp;oacute;pteros para un uso sostenible de insecticidas en la agricultura: avancesen la identificaci&amp;oacute;n de la feromona sexual de Pseudaletia adultera (Lepidoptera: noctuidae)&lt;/strong&gt;</text>
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                <text>Se estima que se conocen m&amp;aacute;s de un mill&amp;oacute;n y medio de especies de insectos, siendo el grupo m&amp;aacute;s diverso de organismos eucariotas, y que un 10% de estas especies constituyen plagas agr&amp;iacute;colas. Los efectos negativos del uso de insecticidas sint&amp;eacute;ticos en la salud, el medio ambiente y los organismos que viven en &amp;eacute;l, fomentan la b&amp;uacute;squeda y desarrollo de estrategias alternativas para el control de plagas. El uso de semioqu&amp;iacute;micos (feromonas y kairomonas) en estrategias de manejo de insectos plaga data de varias d&amp;eacute;cadas; su modo de acci&amp;oacute;n involucra la modificaci&amp;oacute;n del comportamiento de la especie diana y pueden ser utilizados solos o en conjunto con otros compuestos que sean t&amp;oacute;xicos o adhesivos. Los beneficios del uso de feromonas incluyen su inocuidad, ser especie-espec&amp;iacute;ficas y por ende, constituyen una herramienta muy sensible a la detecci&amp;oacute;n de la plaga en bajas poblaciones. En Uruguay, la utilizaci&amp;oacute;n de feromonas en programas de manejo integrado de plagas se inici&amp;oacute; hace ya varias d&amp;eacute;cadas (finales de la d&amp;eacute;cada de 1970), aunque se ha visto limitada a especies de amplia distribuci&amp;oacute;n e importancia econ&amp;oacute;mica internacional. Existen, sin embargo, plagas locales o regionales con alta incidencia econ&amp;oacute;mica, como es el caso de Pseudaletia adultera, para las cuales no se han identificado sus feromonas, dificultando el desarrollo de estrategias alternativas de control. Pseudaletia adultera (Lepidoptera: Noctuidae) es un insecto pol&amp;iacute;fago cuyas preferencias alimenticias son las gram&amp;iacute;neas cultivadas y gram&amp;iacute;neas de praderas naturales; se ha reportado la presencia de esta plaga a nivel local (Norte de Argentina, Sur de Brasil, Paraguay y Uruguay). Su importancia econ&amp;oacute;mica radica en la frecuencia de los ataques (en Uruguay pueden presentar de 3 a 4 generaciones al a&amp;ntilde;o) y la magnitud de los mismos, pudiendo ocasionar da&amp;ntilde;os a hojas, tallos, espigas y granos. En la actualidad, para el muestreo de larvas de esta especie se recomienda el uso de red entomol&amp;oacute;gica; el monitoreo de adultos se realiza mediante trampas de luz. El uso de feromonas sexuales en trampas de monitoreo es un m&amp;eacute;todo sensible y espec&amp;iacute;fico para lepid&amp;oacute;pteros, permitiendo detectar adultos incluso en muy bajas densidades, y predecir explosiones poblacionales. De esta manera, se pueden establecer umbrales de capturas para la adopci&amp;oacute;n de medidas de control qu&amp;iacute;mico. 2 De acuerdo a lo antedicho, el desarrollo de esta tesis se enmarca en la identificaci&amp;oacute;n de la feromona sexual de P. adultera, a trav&amp;eacute;s del conocimiento de la biolog&amp;iacute;a del insecto, la extracci&amp;oacute;n de gl&amp;aacute;ndulas productoras de feromona, identificaci&amp;oacute;n qu&amp;iacute;mica de los compuestos activos y formulaci&amp;oacute;n y evaluaci&amp;oacute;n de una mezcla sint&amp;eacute;tica que simule la feromona sexual. El presente informe de tesis de maestr&amp;iacute;a consta de una introducci&amp;oacute;n que incluye los antecedentes y los objetivos, dos cap&amp;iacute;tulos centrales que describen el trabajo experimental realizado. En el primero se describe la aproximaci&amp;oacute;n a la identificaci&amp;oacute;n de los componentes de la feromona sexual de Pseudaletia adultera, y el segundo describe los estudios comportamentales en laboratorio y ensayos a campo.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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