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                <text>&lt;strong&gt;Modeling anti-Trypanosoma cruzi activity of N-Oxide containing Heterocycles&lt;/strong&gt;</text>
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                <text>In the present study a systematic approach was used to model the anti-T. cruzi activity of a series of N-oxide containing heterocycles belonging to four chemical families with a wide structural diversity. The proposed mode of action implies the reduction of the N-oxide moiety; however, the biochemical mechanism underlying the anti-T. cruzi activity is still unkown. For structural representation two types of descriptors were analyzed: quantum chemical (AM1) global descriptors and properties coded by radial distribution function (RDF). Both types of descriptors point to the relevance of electronic properties. The local-RDF (LRDF) identified an electrophilic center at 4.1-4.9 &amp;Aring; from the oxygen atom of the N-oxide moiety, although other properties are required to explain the biological activity. While the mode of action of N-oxide containing heterocycles is still unknown, the results obtained here strengthen the importance of the electrophilic character of the molecule and the possible participation of the heterocycle in a reduction process. The ability of these descriptors to distinguish among activity classes was assessed using Kohonen neural networks, and the best clustering descriptors were later used for model building. Different learning algorithms were used for model development, and stratified 10-fold cross-validation was used to evaluate the performance of each classifier. The best results were obtained using k-nearest neighbors (k-NN) and decision tree (J48) methods combined with global descriptors. Since tree-based methods are easily translated into classification rules, the J48 model is a useful tool in the de novo construction of new N-oxide containing heterocycle lead structures.</text>
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                <text>Journal of Chemical Information and Modeling v.48, no. 1, 2008. -- p. 213-219</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Yeast had participated with humans in food fermentation since the production of wine and bread, more than 10,000 years of shared history. It is well understood that fungi diversity is still underestimated and that we are far from understanding its importance and potential impact in biotechnology. Flavor compounds as &amp;ldquo;secondary metabolism&amp;rdquo; are very sensitive to fermentation conditions and mixed cultures, and although we had experience an exponential development of molecular biology in the last 30 years, metabolomics is still in its infancy. It was demonstrated in recent years that increase strain and species yeast diversity in a fermentation system increases sensory complexity and chemical aroma compound diversity in the final fermented product. Flavor compounds had many key functions for yeast, such as for survival and dispersion strategies, pheromone and defense mechanisms, and &amp;ldquo;quorum sensing&amp;rdquo; mechanisms for cell communication. Humans had taken advantage of many of these functions to increase taste and food sensory pleasure for a more exigent consumer, a phenomenon called &amp;ldquo;yeast domestication.&amp;rdquo; We focus this chapter mainly in the recent discussed yeast synthetic pathways for the formation of phenylpropanoid and terpenoid aroma compounds.</text>
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                <text>Fungal Metabolites / K. Ramawat, J.M. M&amp;eacute;rillon, eds. Cham : Springer International, 2016 |g p. 1-29</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Benzenoid-derived metabolites act as precursors for a wide variety of products&amp;nbsp; involved in essential metabolic roles in eukaryotic cells. They are synthesised in&amp;nbsp; plants and some fungi through the phenylalanine ammonia lyase (PAL) or tyrosine&amp;nbsp; ammonia lyase (TAL) pathways. Ascomycete yeasts and animals both lack the&amp;nbsp; capacity for PAL/TAL pathways, and metabolic reactions leading to benzenoid&amp;nbsp; synthesis in these organisms have remained incompletely known for decades. Here&amp;nbsp; we show genomic, transcriptomic and metabolomic evidence that yeasts use a&amp;nbsp; mandelate pathway to synthesise benzenoids, with some similarities to pathways&amp;nbsp; used by bacteria. We conducted feeding experiments using a synthetic&amp;nbsp; fermentation medium that contained either 13C-phenylalanine or 13C-tyrosine and,&amp;nbsp; using methylbenzoylphosphonate (MBP) to inhibit benzoylformate decarboxylase,&amp;nbsp; we were able to accumulate intracellular intermediates in the yeast Hanseniaspora&amp;nbsp; vineae. To further confirm this pathway, we tested three mutants in separate&amp;nbsp; fermentation experiments with deletions in the key genes putatively proposed to&amp;nbsp; form benzenoids (Saccharomyces cerevisiae aro10&amp;Delta;, dld1&amp;Delta; and dld2&amp;Delta;). Our results&amp;nbsp; elucidate the mechanism of benzenoid synthesis in yeast through phenylpyruvate&amp;nbsp; linked with the mandelate pathway to produce benzyl alcohol and 4- hydroxybenzaldehyde from the aromatic amino acids, phenylalanine and tyrosine,&amp;nbsp; as well as sugars. These results provide an explanation for the origin of the&amp;nbsp; benzoquinone ring, 4-hydroxybenzoate, and suggest Aro10p has benzoylformate&amp;nbsp; and 4-hydroxybenzoylformate decarboxylase functions in yeast.&amp;nbsp; Keywords: phenylpyruvate pathway, yeast, benzyl alcohol, Hanseniaspora vineae, 4-&amp;nbsp; hydroxybenzoic acid, benzoylformate decarboxylase, ARO10, coenzyme Q.</text>
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                <text>&lt;strong&gt;Boido, Eduardo&lt;/strong&gt;</text>
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                <text>Applied and Environmental Microbiology, 2020. -- p. 1-38</text>
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                <text>American Society for Microbiology</text>
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                <text>&lt;strong&gt;Sensory characterization of virgin olive oil-based cosmetic creams&lt;/strong&gt;</text>
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                <text>ACEITE DE OLIVA</text>
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                <text>COSMETICOS</text>
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                <text>EVALUACION SENSORIAL</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>The influence of olive oil concentration and sensory profile on the odor of virgin olive oil-based cosmetic creams was studied. Four olive oils were selected on the basis of different intensities of positive and defective odor attributes: two extra virgin olive oils, one virgin olive oil, and one ordinary virgin olive oil. Thirty cosmetic creams were prepared, by both cold and hot processing methods, using each of the above oils at concentrations of 3%, 5%, and 10%, in addition to mineral oil controls. A trained sensory panel evaluated the fruitiness and defectiveness intensities in the odor of creams, using unstructured 10-cm scales ranging from "none at all" to "much." The fruity and defective attributes perceived in the odor of creams were significantly influenced by the sensory profile of the starting olive oil, oil concentration, and preparation method. Overall, these findings suggest that virgin olive oils of only slightly fruity odor may be conveniently used for the preparation of cold-processed cosmetic creams, whereas ordinary virgin olive oils appear to be suitable for the preparation of cosmetic creams only by hot processing of the emulsion at a low oil concentration.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>&lt;a title="Curr&amp;iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6837b88d7ee77c6842f15b7a76586c96" target="_blank"&gt;&lt;strong&gt;Parente, Mar&amp;iacute;a Emma&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a title="Curr&amp;iacute;culum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=c2b879ed74672c10135cd7d40d21e3aa" target="_blank"&gt;&lt;strong&gt;G&amp;aacute;mbaro Garc&amp;iacute;a, Adriana&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Boinbaser, Luc&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Roascio, Antonella&lt;/strong&gt;</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Journal of Cosmetic Science v. 64, 2013. -- p. 371-380</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Society of Cosmetic Chemists</text>
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            <name>Date</name>
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                <text>2013</text>
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              <elementText elementTextId="310491">
                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Perceptions of essences for potential use in the development of a line of cosmetic emulsions containing olive oil were studied. Six cream samples prepared with six essences selected in a preliminary study were evaluated for overall liking and intention to purchase by a 63-women sample. A check-all-that-apply (CATA) question consisting of 32 terms was used to gather information about consumer perceptions of fragrance, affective associations, effects on the skin, price, target market, zones of application, and occasions of use. Hierarchical cluster analysis led to the identification of two consumer clusters with different frequency of use of face creams. The two clusters assigned different overall liking scores to the samples and used the CATA terms differently to describe them. A fragrance with jasmine as its principal note was selected for further development of cosmetic creams, as it was awarded the highest overall liking scores by respondents of the two clusters, and was significantly associated with cosmetic features including nourishing, moisturizing, softening, with a delicious and mild smell, and with a natural image, as well as being considered suitable for face and body creams. The use of CATA questions enabled the rapid identification of attributes associated by respondents with a cosmetic cream's fragrance, in addition to contributing relevant information for the definition of marketing and communication strategies.</text>
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                <text>Journal of Cosmetic Science v. 65, no. 3, 2014. -- p. 161-173</text>
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                <text>Society of Cosmetic Chemists</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Word association technique applied to cosmetic products : a case study&lt;/strong&gt;</text>
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                <text>ACEITE DE OLIVA</text>
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                <text>COSMETICOS</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>Word association, a projective qualitative technique, was applied to the development of olive oil-based and olive leaf extract-supplemented cosmetic creams. One hundred twenty female respondents presented with five stimulus terms &amp;ndash; namely, &amp;ldquo;nourishing cream,&amp;rdquo; &amp;ldquo;antiaging cream,&amp;rdquo; &amp;ldquo;olive oil-based cream,&amp;rdquo; &amp;ldquo;olive leaf extract-supplemented cream&amp;rdquo; and &amp;ldquo;antioxidant-rich cream&amp;rdquo; &amp;ndash; were asked to write down four images, associations, thoughts or feelings evoked by each of the different stimuli. Word associations made by the surveyed sample were then grouped into 14 categories. For each of the proposed stimuli, the frequency of mention of elicited words was analyzed according to and within each category. The use of word association enabled the identification of expected or desired sensory properties and efficacy of the studied cosmetic creams, as well as the concepts associated &amp;ndash; in the minds of respondents &amp;ndash; with each of the creams. The resulting information may be used to optimize the selection of new products and their denominations.</text>
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                <text>&lt;a title="Curr&amp;iacute;culum vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=c2b879ed74672c10135cd7d40d21e3aa" target="_blank"&gt;&lt;strong&gt;G&amp;aacute;mbaro Garc&amp;iacute;a, Adriana&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Roascio, Antonella&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Boinbaser, Luc&amp;iacute;a&lt;/strong&gt;</text>
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                <text>Journal of Sensory Studies v. 29, no. 2, 2014. -- p. 103-109</text>
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                <text>Wiley</text>
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                <text>&lt;p style="margin-bottom: 0cm;" align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity is one of its main economic activities, rendering new higher-value products with a concomitant solution to waste accumulation issues. To that end, in this work we describe and characterise bioactive compounds generation from rice husk by semi-solid fermentation, obtained from 500 g of the material at room temperature and 60% humidity with mixed cultures of Phanerochaete chrysosporium and Gloeophyllum trabeum. The extract was evaluated in different situations: murine mammary tumour cells (4T1), normal cells (NIH 3T3) and in Lactobacillus acidophilus, and Trichoderma harzianum. The results exhibited that the extract inhibited 4T1 cells at concentrations higher than 20&amp;mu;g/mL, but did not inhibit normal cells, and displayed germicide activity after 3 days incubations. We propose that these functionalized compounds have a potential application in industry/agriculture/medicine obtained from rice husk waste.</text>
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                <text>Journal of Renewable Materials v. 7, no. 4, 2019. -- p. 313-324</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Alb&amp;uacute;mina s&amp;eacute;rica humana: oxidaci&amp;oacute;n del tiol y glicaci&amp;oacute;n&lt;/strong&gt;</text>
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                <text>La alb&amp;uacute;mina s&amp;eacute;rica humana (HSA) es la prote&amp;iacute;na mayoritaria en el plasma, y cumple varias funciones, entre ellas atrapar especies oxidantes y electr&amp;oacute;filas. Esta funci&amp;oacute;n se asocia a su residuo de ciste&amp;iacute;na libre, Cys34, el cual representa m&amp;aacute;s del 80 % de los tioles libres en plasma. Este tiol puede reaccionar con per&amp;oacute;xidos (i.e. oxidarse) para dar un &amp;aacute;cido sulf&amp;eacute;nico de vida media larga, el cual puede seguir tres destinos: reducirse por reacci&amp;oacute;n con un tiol para formar un disulfuro mixto, oxidarse irreversiblemente a &amp;aacute;cido sulf&amp;iacute;nico, o decaer espont&amp;aacute;neamente a un producto a&amp;uacute;n no caracterizado. Por otro lado, dada su prolongada vida media, la HSA es susceptible a ser modificada (glicada) por compuestos carbon&amp;iacute;licos reductores presentes en el plasma, generando productos de glicaci&amp;oacute;n. Dichas modificaciones alteran la estructura y funci&amp;oacute;n de la HSA. En particular, se ha sugerido que habr&amp;iacute;a una interacci&amp;oacute;n sin&amp;eacute;rgica entre la glicaci&amp;oacute;n de la HSA y la oxidaci&amp;oacute;n del tiol. En este trabajo de tesis se us&amp;oacute; un conjunto de t&amp;eacute;cnicas experimentales y de modelado computacional para estudiar las propiedades del tiol de la HSA y de su derivado &amp;aacute;cido sulf&amp;eacute;nico, y tambi&amp;eacute;n, la interacci&amp;oacute;n entre la glicaci&amp;oacute;n de la HSA y la oxidaci&amp;oacute;n del Cys34. Seis aspectos principales fueron tratados: (1) la estructura y din&amp;aacute;mica del entorno del residuo Cys34 en las formas tiol y tiolato; (2) los mecanismos de las reacciones del tiolato de la HSA con per&amp;oacute;xidos; (3) la estructura y din&amp;aacute;mica del entorno de Cys34 en las formas &amp;aacute;cido sulf&amp;eacute;nico y sulfenato; (4) el mecanismo de la reacci&amp;oacute;n del &amp;aacute;cido sulf&amp;eacute;nico de la HSA con H2O2; (5) la interacci&amp;oacute;n entre la glicaci&amp;oacute;n de la HSA y la oxidaci&amp;oacute;n del tiol; y (6) la reacci&amp;oacute;n del tiol de la HSA con metilglioxal. Lateralmente, tambi&amp;eacute;n se valid&amp;oacute;, metodolog&amp;iacute;a tanto experimental como computacional, para describir este tipo de problemas. En primer lugar, se determin&amp;oacute; que los residuos Tyr84 y Asp38 cumplen un papel importante modulando propiedades del tiol tales como la acidez y la nucleofilia, y se asign&amp;oacute; un rol estructural a His39. Otro hallazgo importante es que el tiol(ato) interacciona con mol&amp;eacute;culas de agua que hacen de puente con el carboxilato de Asp38. En segundo lugar, se confirm&amp;oacute; el car&amp;aacute;cter SN2 del mecanismo de las reacciones del tiolato de la HSA con per&amp;oacute;xidos, obteniendo energ&amp;iacute;as libres de activaci&amp;oacute;n de respectivamente 14.2 y 10.4 kcal mol&amp;minus;1 para las reacciones con H2O2 y HOONO. Como hallazgo mecan&amp;iacute;stico importante, se aprecia que, mientras en la reacci&amp;oacute;n con H2O2 se da una transferencia prot&amp;oacute;nica &amp;ldquo;post-estado de transici&amp;oacute;n&amp;rdquo;, 7 esto no ocurre en su an&amp;aacute;loga con HOONO, mostrando que la naturaleza del grupo saliente determina la naturaleza del producto de reacci&amp;oacute;n. En paralelo, se determin&amp;oacute; experimentalmente un valor de entalp&amp;iacute;a de activaci&amp;oacute;n de 13.7 kcal mol&amp;minus;1, pr&amp;oacute;ximo al valor resultante del modelado de 12.9 kcal mol&amp;minus;1. En tercer lugar, se lleg&amp;oacute; a dos hallazgos importantes respecto al entorno del &amp;aacute;cido sulf&amp;eacute;nico de la HSA: (a) la presencia de un enlace de hidr&amp;oacute;geno persistente entre el &amp;aacute;cido sulf&amp;eacute;nico y el carboxilato de Asp38; y (b) la cercan&amp;iacute;a del NH pept&amp;iacute;dico de Cys34 al S&amp;gamma; del &amp;aacute;cido sulf&amp;eacute;nico, que adem&amp;aacute;s se encuentra formando enlace de hidr&amp;oacute;geno (puenteado por agua) con el imidazol de His39. Adem&amp;aacute;s, se estim&amp;oacute; que el p</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>&lt;strong&gt;Marcha sistem&amp;aacute;tica simult&amp;aacute;nea de aniones y cationes : 5a. parte. Estudio del 4&amp;ordm; y 5&amp;ordm; grupos&lt;/strong&gt;</text>
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                <text>1955</text>
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                <text>&lt;strong&gt;Saredo, Juan F.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Lema, Jos&amp;eacute; D.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Bonet, Walter&lt;/strong&gt;</text>
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                <text>Anales de la Facultad de Qu&amp;iacute;mica y Farmacia (Uruguay) v. 4, 1955. -- p. 103-122</text>
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            <name>Publisher</name>
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                <text>Facultad de Qu&amp;iacute;mica y Farmacia (Uruguay)</text>
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              <elementText elementTextId="668618">
                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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            <name>Type</name>
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                <text>&lt;strong&gt;Optimization of emulsification conditions with rice bran concentrates for the preliminary formulation of potential vegan dressings and their characterization&lt;/strong&gt;</text>
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                <text>SALVADO DE ARROZ</text>
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                <text>A fraction of rice bran (RB), generated during the brown rice polishing, is utilized to extract oil, resulting in defatted RB (DRB). The aim of this study was to optimize the emulsification conditions to enhance the value of this byproduct by formulating potential vegan dressings and characterizing them. Enzymatic hydrolysis of the starch present in DRB yields the DRB concentrate (DRBC). A central composite design was applied and the results were analyzed using response surface methodology to select optimal conditions for an oil-in-water emulsion formula. Two formulations were chosen: one corresponds to the optimal conditions, with 26.5% of oil and 73.5% of DRBC dispersion (eoptimal), and the other one with 21.7% of oil and 78.3% of dispersion (eED8). The eoptimal formulation exhibited significantly lowermean De Brouckere diameter (D4,3) value and higher viscosity when compared with eED8. For both emulsions, the particle size distribution and D4,3 remained unchanged during storage, whereas viscosity decreased, and backscattering (BS) increased. Initially, both emulsions exhibited solid viscoelastic behavior, whichwas partially lost during quiescent storage. The increase in BS was attributed to particle disaggregation, ultimately leading to the aforementioned change in rheological behavior. In conclusion, although the designed emulsions underwent microstructural changes, they were stable against gravitational separation. To improve stability during quiescent storage, it is suggested to incorporate a thickening agent. Hence, it is propose to procced with the development of a vegan dressing based on the eoptimal emulsion, as it exhibits superior physicochemical properties.</text>
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                <text>&lt;strong&gt;Bonifacino, Carla&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Abirached, Cecilia&lt;/strong&gt;</text>
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                <text>Journal of Food Science v.89, n&amp;deg;4, 2024. -- pp. 2174-2187</text>
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            <elementTextContainer>
              <elementText elementTextId="695754">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>El &amp;oacute;xido n&amp;iacute;trico (&amp;bull;NO) cumple potentes acciones reguladoras en la funci&amp;oacute;n celular y viabilidad tisular. La disminuci&amp;oacute;n en su biodisponibilidad observada durante procesos inflamatorios cr&amp;oacute;nicos y agudos responde a su transformaci&amp;oacute;n en especies reactivas del nitr&amp;oacute;geno (ERN) y tiene un rol cr&amp;iacute;tico en la regulaci&amp;oacute;n de la oxidaci&amp;oacute;n lip&amp;iacute;dica y en la consecuente formaci&amp;oacute;n de derivados nitrados de l&amp;iacute;pidos (nitroalquenos) con efectos anti-&amp;shy;‐ inflamatorios. Los nitrol&amp;iacute;pidos se forman in vivo y se han convertido en los &amp;uacute;ltimos 20 a&amp;ntilde;os en uno de los principales objetos de estudio en el &amp;aacute;rea de la qu&amp;iacute;mica oxidativa de macromol&amp;eacute;culas. Nuestro grupo ha caracterizado qu&amp;iacute;micamente la s&amp;iacute;ntesis y purificaci&amp;oacute;n de &amp;aacute;cido nitroaraquid&amp;oacute;nico (NO2AA), un nitroalqueno con propiedades biol&amp;oacute;gicas asociadas a su capacidad anti-&amp;shy;‐inflamatoria. El &amp;aacute;cido araquid&amp;oacute;nico (AA&amp;bull;) es precursor de una amplia variedad de l&amp;iacute;pidos bioactivos, entre ellos los eicosanoides derivados de la v&amp;iacute;a Prostaglandina G/H sintasa (PGHS), y postulamos que su nitraci&amp;oacute;n para formar NO2AA podr&amp;iacute;a representar un mecanismo fundamental de modulaci&amp;oacute;n de los procesos inflamatorios vinculados al AA. En ese contexto integramos t&amp;eacute;cnicas bioqu&amp;iacute;micas, prote&amp;oacute;micas y computacionales para caracterizar cin&amp;eacute;tica y estructuralmente la interacci&amp;oacute;n de NO2AA con PGHS-&amp;shy;‐1 y PGHS-&amp;shy;‐2. Demostramos que el NO2AA es capaz de inactivar estas enzimas en forma irreversible, exhibiendo una potencia comparable a la de las drogas antiinflamatorias no esteroideas (AINES). Trasladamos este resultado a modelos celulares de relevancia biol&amp;oacute;gica en el metabolismo de AA: plaquetas humanas y macr&amp;oacute;fagos murinos. El NO2AA inhibi&amp;oacute; la actividad PGHS-&amp;shy;‐1 y PGHS-&amp;shy;‐2 in vivo, ejerciendo un potente efecto anti-&amp;shy;‐agregante en plaquetas modulando el metabolismo normal del AA sumado a su acci&amp;oacute;n sobre blancos adicionales a PGHS-&amp;shy;‐1. Finalmente, ponemos a punto un sistema de reacciones para evaluar la s&amp;iacute;ntesis catal&amp;iacute;tica de NO2AA por la actividad PGHS y proponemos un posible mecanismo de regulaci&amp;oacute;n plaquetaria in vivo.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;em&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege&lt;/strong&gt;&lt;/em&gt; el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Nitro-fatty acids represent endogenously occurring products of oxidant-induced nitration reactions. We have previously synthesized amixture of four isomers of nitroarachidonic acid, a novel anti-inflammatory signaling mediator. In this study, we synthesized and chemically and biologically characterized for the first time an esterified nitroalkene derived from the nitration of methylarachidonate (AAMet): 6-methylnitroarachidonate (6-AAMetNO2). Synthesis was performed by reacting AAMet with sodium nitrite under acidic conditions. Analysis by mass spectrometry (positive-ion ESI-MS) showed an [M+H]+ ion of m/z 364, characteristic of AAMetNO2. Fragmentation of this ion yielded a daughter ion at m/z 317, corresponding to the neutral loss of the nitro group ([M+H&amp;minus;HNO2]+). Furthermore, IR signal at 1378 cm&amp;minus;1 and NMR data confirmed the structure of a 6-nitro-positional isomer. This novel esterified nitroalkene was capable of promoting vascular protective actions including: (a) the induction of vasorelaxation via endothelium-independent mechanisms, associated with an increase in smooth muscle cell cGMP levels, and (b) a potent dose-dependent inhibition of human platelet aggregation. We postulate that 6-AAMetNO2 could be a potential drug for the prevention of vascular and inflammatory diseases, and the presence of the methyl group may increase its pharmacological potential.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;&#13;
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                <text>&lt;strong&gt;Production and characterization of a new bioemulsifiers from Pseudomonas putida ML2.&lt;/strong&gt;</text>
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                <text>Aims: To characterize the bioemulsifier produced by a nonfluorescent strain of Pseudomonas putida isolated from a polluted sediment and to determine the influence of pH, temperature, media composition, and carbon and nitrogen source on growth and emulsifying activity. Methods and Results: Different indexes were employed to determine the emulsifying properties of culture supernatants of P. putida ML2 in defined and complex media. Surface tension of cell-free supernatants was measured. Purification and chemical analysis of the emulsifier was performed. Confirmed results indicate that a polysaccharide with hexasaccharide repeating units is responsible for the emulsifying activity in a mineral medium with glucose as sole carbon source. Moreover, an emulsifier is produced when growing on naphthalene. Conclusions: Culture media composition influences the amount and the properties of the emulsifier produced by this P. putida strain. Under nitrogen limiting conditions, a polysaccharide is responsible for the emulsifying activity in defined mineral media. In complex nitrogen rich medium, a different kind of emulsifier is produced. The exopolymer may contribute to hydrocarbons solubilization. Significance and Impact of the Study: This is the first exopolysaccharide with emulsifying properties produced by a Pseudomonas strain reported to the present. Also chemical composition is significantly different from previous reports. This strain has potential use in bioremediation and the purified polysaccharide may be used in food and cosmetic industry. Moreover, the production of the exopolymer may play a role on biofilm formation.</text>
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                <text>&lt;strong&gt;Bonilla, M&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Olivaro, C&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum" href="http://www.ccdt.udelar.edu.uy/wp-content/themes/corpo/adjuntos/604_curriculumvitae__curriculumvitaearchivo.pdf"&gt;&lt;strong&gt;V&amp;aacute;zquez, Alvaro&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Journal of Applied Microbiology v. 98, no. 2, 2005. -- p. 456-463</text>
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                <text>The Society for Applied Microbiology</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>In most organisms, thioredoxin (Trx) and/or glutathione (GSH) systems are essential for redox homeostasis and deoxyribonucleotide synthesis. Platyhelminth parasites have a unique and simplified thiol-based redox system, in which the selenoprotein thioredoxin-glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase domains, is the sole enzyme supplying electrons to oxidized glutathione (GSSG) and Trx. This enzyme has recently been validated as a key drug target for flatworm infections. In this study, we show that TGR possesses GSH-independent deglutathionylase activity on a glutathionylated peptide. Furthermore, we demonstrate that deglutathionylation and GSSG reduction are mediated by the Grx domain by a monothiolic mechanism and that the glutathionylated TGR intermediate is resolved by selenocysteine. Deglutathionylation and GSSG reduction via Grx domain, but not Trx reduction, are inhibited at high [GSSG]/[GSH] ratios. We found that Trxs (cytosolic and mitochondrial) provide alternative pathways for deglutathionylation and GSSG reduction. These pathways are operative at high [GSSG]/[GSH] and function in a complementary manner to the Grx domain-dependent one. Despite the existence of alternative pathways, the thioredoxin reductase domains of TGR are an obligate electron route for both the Grx domain- and the Trx-dependent pathways. Overall, our results provide an explanation for the unique array of thiol-dependent redox pathways present in parasitic platyhelminths. Finally, we found that TGR is inhibited by 1-hydroxy-2-oxo-3-(N-3-methyl-aminopropyl)-3-methyl-1-triazene (NOC-7), giving further evidence for NO donation as a mechanism of action for oxadiazole N-oxide TGR inhibitors. Thus, NO donors aimed at TGR could disrupt the entire redox homeostasis of parasitic flatworms.</text>
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                <text>Journal of Biological Chemistry v. 286, no. 7, 2011. -- p. 4959-4967</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host.&lt;/strong&gt;</text>
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                <text>SELENIO</text>
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                <text>SELENIOCISTEINA</text>
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                <text>&lt;p&gt;The trace element selenium is found in polypeptides as selenocysteine, the 21stamino acid that is co-translationally inserted into proteins at a UGA codon. In proteins, selenocysteine usually plays a role asan efficient redox catalyst. Trypanosomatids previously examined harbor a full set of genes encodingthe machinery needed for selenocysteine biosynthesis and incorporation into three selenoproteins: SelK,SelT and, the parasite-specific, Seltryp. We investigated the selenoproteome of kinetoplastid speciesin recently sequenced genomes and assessed the in vivo relevance of selenoproteins for African try-panosomes. Database mining revealed that SelK, SelT and Seltryp genes are present in most kinetoplastids,including the free-living species Bodo saltans, and Seltryp was lost in the subgenus Viannia from theNew World Leishmania. Homology and sinteny with bacterial sulfur dioxygenases and sulfur transferasessuggest a putative role for Seltryp in sulfur metabolism. A Trypanosoma brucei selenocysteine synthase(SepSecS) null-mutant, in which selenoprotein synthesis is abolished, displayed similar sensitivity tooxidative stress induced by a short-term exposure to high concentrations of methylglyoxal or H2O2tothat of the parental wild-type cell line. Importantly, the infectivity of the SepSecS knockout cell line wasnot impaired when tested in a mouse infection model and compensatory effects via up-regulation ofproteins involved in thiol-redox metabolism were not observed. Collectively, our data show that seleno-proteins are not required for survival of African trypanosomes in a mammalian host and exclude a rolefor selenoproteins in parasite antioxidant defense and/or virulence. On this basis, selenoproteins can bedisregarded as drug target candidates.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Bonilla, Mariana&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Krull, Erika&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Comini, Marcelo A.&lt;/strong&gt;</text>
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                <text>Molecular &amp;amp; Biochemical Parasitology , 2016. Disponible Online</text>
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                <text>Elsevier</text>
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                <text>&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>http://dx.doi.org/10.1016/j.molbiopara.2016.03.002</text>
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                <text>&lt;strong&gt;A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes&lt;/strong&gt;</text>
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                <text>African trypanosomiasis is a major problem for human and animal health in endemic countries, where it threatens millions of people and affects economic development. New drugs are needed to overcome the toxicity, administration, low efficacy, and resistance issues of the current chemotherapy. Robust, simple, and economical high‐throughput, whole‐cell‐based assays are required to accelerate the identification of novel chemical entities. With this aim, we generated a bioluminescent cell line of the bloodstream stage of Trypanosoma brucei brucei and established a screening assay. Trypanosomes were stably transfected to constitutively express a thermostable red‐shifted luciferase. The growth phenotype and drug sensitivity of the reporter cell line were essentially identical to that of the parental cell line. The endogenous luciferase activity, measured by a simple bioluminescence assay, proved to be proportional to parasite number and metabolic status. The assay, optimized to detect highly potent compounds in a 96‐well‐plate format, was validated by screening a small compound library (inter‐assay values for Z' factor and coefficient variation were 0.77 and 5.8%, respectively). With a hit‐confirmation ratio of ~97%, the assay was potent enough to identify several hits with EC50&amp;thinsp;&amp;le;&amp;thinsp;10 &amp;mu;M. Preliminary tests indicated that the assay can be scaled up to a 384‐well‐plate format without compromising its robustness. In summary, we have generated reporter trypanosomes and a simple, robust, and affordable bioluminescence screening assay with great potential to speed up the early‐phase drug discovery against African trypanosomes.</text>
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                <text>The electrochemical behaviour of polycrystalline Ti electrodes was studied in dilute aqueous alkaline solutions at 25 &amp;deg;C. Fast repetitive potential programmes (triangular and square waves) were applied to Ti electrodes to grow different O-containing films. The growth efficiency of Ti oxides principally depends on the upper potential limit of the corresponding program. Potentiostatic preillumination of Ti electrodes produces surface modifications that can be followed by cyclic voltammetry. Two types of photoactive surface sites are evidenced; one coinciding with the potential window of the photogenerated molecular oxygen electroreduction reaction, and the other resulting from the electroreduction of photoformed oxygenated radicals. The application of both potential programmes and illumination can change the electrochemical properties of Ti surfaces in alkaline solutions.</text>
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                <text>&lt;strong&gt;Bonilla, S.H&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Zinola S&amp;aacute;nchez, Carlos Fernando&lt;/strong&gt;</text>
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                <text>Electrochimica acta v. 43, no. 3/4, 1998. -- p. 423</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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                <text>&lt;strong&gt;Contribuci&amp;oacute;n a la determinaci&amp;oacute;n de f&amp;oacute;sforo con el reactivo vanadomolibdico.&lt;/strong&gt;</text>
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                <text>La determinación espectrofotométrica del fósforo con el reactivo vanadomolibdico es ampliamente aplicada a variados problemas analíticos, y usualmente las medidas se efectúan a longitudes de onda superiores a 400 nm. Cuando la sensibilidad se convierte en factor crítico, suele preferirise el método del azul de molibdemo. En el presente trabajo dirijido al análisis foliar de P, se demuestra que con el reactivo vanadomolíndico puede lograrse una sensibilidad comparable a la del azul de molibdeno si las medidas se efectúan a 315 nm. La mayor estabilidad de la abosrbancia se logra en medio sulfúrico ca. 012N. Se detecta una ligera desviación de la ley de Bouguer-Beer y un comportamiento anormal en las proximidades del límite de detección. Se efectúa un análisis de la varianza del método y se estudia su correlación con el método del azul de molibdeno.</text>
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                <text>Anales de la Facultad de Qu&amp;iacute;mica. v.9, 1979. -- p. 145-160.</text>
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&lt;p align="LEFT"&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</text>
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