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                <text>&lt;strong&gt;Triple Doped Monolayer Graphene with Boron, Nitrogen, Aluminum, Silicon, Phosphorus and Sulfur&lt;/strong&gt;</text>
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                <text>The structure, stability, electronic properties and chemical reactivity of X/B/N triple‐doped graphene (TDG) systems (X=Al, Si, P, S) are investigated by means of periodic density functional calculations. In the studied TDGs the dopant atoms prefer to be bonded to one another instead of separated. In general, the XNB pattern is preferred, with the exception of sulfur, which favors the SBN motif. The introduction of a third dopant results in a negligible decrease of the cohesive energies with respect to the dual‐doped graphene (DDG) counterparts. Thus, it is expect that these systems can be prepared soon. For SiNB TDG, the introduction of the B dopant reduces the gap opening at the K point and restores the Dirac cones that are destroyed in SiN DDG. On the contrary, for PNB TDG, the bandgap is increased with respect to PN DDG, probably because the introduction of B weakens the PN bonding, and thus the electronic structure is rather similar to that of P‐doped graphene. Finally, with regard to the reactivity of the TDGs, for AlNB, PNB, and SNB the carbon atoms are more reactive than in their AlN, PN, and SN DDG counterparts. On the contrary, the reactivity of SiNB is lower than that of SiN DDG. Therefore, to increase the reactivity of graphene, Al, P, and S should be combined with BN motifs</text>
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                <text>First-principles density functional theory (DFT) calculations were performed to investigate the lithium (Li) adsorption upon beryllium (Be) doped graphene. Be acts as hole doping in graphene leaving the structure as electron deficient, offering a greater tendency for Li adsorption than in pristine and boron (B) doped graphene. The introduction of Be augments the adsorption energy of Li from &amp;minus;1.11 to &amp;minus;2.53 eV/Li. Furthermore, 12, and 16 Li ions can easily be captured by one Be center in the single and double vacancy case, respectively, with the adsorption energies of &amp;minus;1.33 eV/Li (for both the cases), showing that Be doped graphene is an excellent anode material for lithium ion batteries (LIBs). Consequently, the presence of structural defects, in particular, a divacancy is found to be more efficient in terms of Li storage capacity. A huge Li storage capacity (2303.295 mAh/g) is calculated for Li8BeC7 having reasonable adsorption energy (&amp;minus;1.47 eV/Li). Our calculated capacity is 6.19 times greater than that of the graphite.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The use of ketohexose isomerases is a powerful tool in lactose whey processing, but these enzymes can be very sensitive and expensive. Development of immobilized/stabilized biocatalysts could be a further option to improve the process. In this work, &amp;beta;-galactosidase from Bacillus circulans, l-arabinose (d-galactose) isomerase from Enterococcus faecium, and d-xylose (d-glucose) isomerase from Streptomyces rubiginosus were immobilized individually onto Eupergit C and Eupergit C 250 L. Immobilized activity yields were over 90% in all cases. With the purpose of increasing thermostability of derivatives, two post-immobilization treatments were performed: alkaline incubation to favor the formation of additional covalent linkages, and blocking of excess oxirane groups by reacting with glycine. The greatest thermostability was achieved when alkaline incubation was carried out for 24 h, producing l-arabinose isomerase-Eupergit C derivatives with a half-life of 379 h and d-xylose isomerase-Eupergit C derivatives with a half-life of 554 h at 50 &amp;deg;C. Preliminary assays using immobilized and stabilized biocatalysts sequentially to biotransform lactose at pH 7.0 and 50 &amp;deg;C demonstrated improved performances as compared with soluble enzymes. Further improvements in ketohexose productivities were achieved when the three single-immobilizates were incubated simultaneously with lactose in a mono-reactor system.</text>
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                <text>&lt;strong&gt;Torres, Pedro&lt;/strong&gt;</text>
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                <text>Molecules v.22, no. 2, 2017. --15p.--e284</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&amp;nbsp;&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Crystal structure and absolute configuration of (4S,5R,6S)-4,5,6-trihydroxy-3-methylcyclohex-2- enone (gabosine H)&lt;/strong&gt;</text>
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                <text>REACCION DE MITSONOBU</text>
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                <text>The mol&amp;shy;ecule of the title keto carbasugar, C7H10O4, is formed by a cyclo&amp;shy;hexene skeleton with an envelope conformation, substituted by carbonyl, methyl and hydroxyl groups. The crystal structure is controlled mainly by a combination of strong O&amp;mdash;H⋯O and weak C&amp;mdash;H⋯O hydrogen bonds, forming nearly perpendicular chains running parallel to the [110] and [-110] directions. This perpendicularity is caused by a tetra&amp;shy;gonal pseudosymmetry influenced by the similarity between the a and b axes, the value of 90.9770 (10)&amp;deg; of the &amp;beta; angle and the action of a 21 screw axis, which transform each chain into its corresponding nearly orthogonal one.</text>
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                <text>&lt;strong&gt;Tibhe, Gaurao D.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mac&amp;iacute;as, Mario A&lt;/strong&gt;</text>
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                <text>Acta Crystallographica Section E: Crystallographic Communications&amp;nbsp; v. 73, 2017. -- p. 606-609</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Gabosines constitute a group of naturally occurring compounds with unique structures that exhibit very interesting biological activities. Synthetic efforts have been continuously reported since 1985. In this work, multistep total syntheses of natural gabosine H and non-natural gabosines have been accomplished by using a chemoenzymatic approach. Chirality was transferred from the starting material 3-methyl-cis-1,2-cyclohexadienediol, which was obtained by biotransformation of toluene. Protection of the diol followed by iodohydroxylation or dihydroxylation of the less hindered double bond and further functional group transformations, permitted us to build up the synthetic sequences to the final products. The chemical structures and the absolute configurations of two key intermediates and two final products were confirmed by X-ray diffraction.</text>
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                <text>Synthesis v. 49, no. 3, 2017. -- p. 565-570</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Biological performance of particleboard incorporated with boron minerals&lt;/strong&gt;</text>
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                <text>MINERALES</text>
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                <text>We compared resistance to decay, mold fungi, termites and insect larvae of particleboards incorporated with the raw boron minerals ulexite and colemanite to that of particleboards impregnated with the commercial boron preservative zinc borate, or boric acid plus a borax mixture. We also quantified water absorption, thickness swell and boron release of particleboards. Ulexite had the best decay resistance, and colemanite had the best termite resistance. However, ulexite and colemanite were not as effective as zinc borate or the boric acid/borax mixture in preventing mold growth. In general, the boric acid/borax mixture combination was more effective against Anobium larvae than the other treatments. Less boron was released by specimens containing zinc borate and colemanite than by those containing ulexite or the boric acid/borax mixture. In general, water absorption and thickness swell were similar among the different treatments, but both were slightly higher in the ulexite-incorporated specimens. Further mechanical tests will be needed to evaluate the particleboard properties and thereby the compatibility of these boron minerals with various manufacturing processes.</text>
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                <text>&lt;strong&gt;Terzi, Evren&lt;/strong&gt;</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Development and characterisation of a 99mTc tricarbonyl labelled estradiol derivative obtained by &amp;ldquo;Click Chemistry&amp;rdquo; with potential application in estrogen receptors imaging&lt;/strong&gt;</text>
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                <text>Assessment of the presence of estrogen receptors in breast cancer is crucial for treatment planning. With the objective to develop a potential agent for estrogen receptors imaging, we present the development and characterization of a 99mTc‐tricarbonyl&amp;ndash;labelled estradiol derivative. Using ethinylestradiol as starting material, an estradiol derivative bearing a 1,4‐disubstituted 1,2,3‐triazole&amp;ndash;containing tridentate ligand system was synthesized by &amp;ldquo;Click Chemistry&amp;rdquo; and fully characterized. Labelling with high yield and radiochemical purity was achieved through the formation of a 99mTc‐tricarbonyl complex. The radiolabelled compound was stable, exhibited moderate binding to plasma protein (approximately 33%) and lipophilicity in the adequate range (logP 1.3 &amp;plusmn; 0.1 at pH 7.4). Studies in MCF7 showed promising uptake values (approximately 2%). However, more than 50% of the activity is quickly released from the cell. Biodistribution experiments in normal rats confirmed the expected &amp;ldquo;in vivo&amp;rdquo; stability of the radiotracer but showed very high gastrointestinal and liver activity, which is inconvenient for in vivo applications. Taking into consideration the well‐documented influence of the chelating system in the physicochemical and biological behaviour of technetium‐labelled small biomolecules, research will be continued using the same pharmacophore but different complexation modalities of technetium.</text>
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                <text>Journal of Labelled Compounds and Radiopharmaceuticals&amp;nbsp; v. 60, no. 11, 2017. -- p. 521-527</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;The Effect of A Hexanoic Acid Linker Insertion on the Pharmacokinetics and Tumor Targeting Properties of the Melanoma Imaging Agent 99mTc-HYNIC-cycMSH&lt;/strong&gt;</text>
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                <text>Background: Lactam cyclized alpha-melanocyte stimulating hormone (&amp;alpha;-MSH) analogues exhibit high stability and affinity for the MC1-R receptors over expressed in melanoma cells. Recently, we reported a novel &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; analogue with the HYNIC chelator directly attached to the lactam cyclized ring. Objective: In this study we proposed the introduction of a 6-aminohexanoic acid (Ahx) linker between the HYNIC chelator and lactam cyclized peptide cycMSH4-13 to reduce steric hindrance and improve the melanoma targeting and imaging proprieties of the radiolabeled peptide. Method: HYNIC-Ahx-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; peptide was synthesized on an automated peptide synthesizer and displayed an IC50 of 0.3 nM using B16/F1 cells. The 99mTc/tricine radiolabeled peptide was examined for radiochemical purity, stability and cell binding. In vivo, biodistribution and planar gamma imaging studies were performed in B16/F1 melanoma tumor bearing C57BK mice. Results: &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-Ahx-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; was obtained with a radiochemical purity &amp;gt;95%, was stable up to 24 h at room temperature and exhibited high binding and rapid internalization in B16/F1 cells. In vivo biodistribution studies showed a tumor uptake of 4.92 &amp;plusmn; 0.92 % ID/g and 2.78 &amp;plusmn; 1.48 % ID/g at 2 h and 4 h post injection, respectively. Whole-body clearance was rapid through urinary excretion. The melanoma tumors were clearly visualized by planar gamma imaging. Conclusion: &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-Ahx-cycMSH&lt;sub&gt;4-13&lt;/sub&gt; was shown radiochemically stability and exhibited rapid and selective uptake in melanoma cells and tumors. Imaging studies yielded promising preclinical results, warranting further evaluation of &lt;sup&gt;99m&lt;/sup&gt;Tc-HYNIC-cycMSH analogs as melanoma specific imaging agent</text>
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                <text>Anti-Cancer Agents in Medicinal Chemistry v. 17, no. 8, 2017. -- p. 1144-1152</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>In this work the thermal behavior of wood impregnated with ZnCl2 is studied. Impregnation of wood with ZnCl2 is a treatment used in activated carbon production, and liquefaction and fast pyrolysis of biomass. Frequently, the impregnated wood is dried for several hours at temperatures above 370 K and then it is carbonized. Catalytic pyrolysis occurs, giving rise to a complex set of reactions. A TG/DTA study was done on the raw material, the activated carbon, the pure ZnCl2 and the intermediate products in order to study the mass and thermal changes occurring. Elemental analysis and SEM analysis were also carried out. An exothermic torrefaction develops during the drying step; the torrefied product is carbonized in an endothermic process that involves ZnCl2 volatilization. The washed impregnated wood carbonizes through an exothermic process that may involve the decomposition of cellulose, lignin and the solid product of hemicellulose torrefaction.</text>
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                <text>European Journal of Wood and Wood Products v. 75, no. 4, 2017. -- p. 633-638</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Avalia&amp;ccedil;&amp;atilde;o da atividade anti-Mycobacterium tuberculosis e citotoxicidade dos ligantes hinokitiol e tropolona e seus complexos com pal&amp;aacute;dio e platina&lt;/strong&gt;</text>
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                <text>Introdu&amp;ccedil;&amp;atilde;o: Em 2015 o agente etiol&amp;oacute;gico Mycobacterium tuberculosis (MTB), causador da tuberculose, alcan&amp;ccedil;ou 10,4 milh&amp;otilde;es de pessoas no mundo, ficando em primeiro lugar entre as doen&amp;ccedil;as infecto-contagiosas que mais matam pessoas. O seu dif&amp;iacute;cil combate &amp;eacute; devido principalmente ao surgimento das cepas resistentes, por isso o descobrimento de novas mol&amp;eacute;culas se faz necess&amp;aacute;rio. Neste trabalho determinou-se a concentra&amp;ccedil;&amp;atilde;o inibit&amp;oacute;ria m&amp;iacute;nima (CIM90), que &amp;eacute; a concentra&amp;ccedil;&amp;atilde;o capaz de inibir 90% do crescimento bacteriano dos ligantes hinokitiol (hino) e tropolona (trop) e seus complexos com Pt (platina) e Pd (pal&amp;aacute;dio contra MTB H37Rv (ATCC 27294) e quatro cepas cl&amp;iacute;nicas resistentes a f&amp;aacute;rmacos. Determinou-se tamb&amp;eacute;m o IC50, que &amp;eacute; a concentra&amp;ccedil;&amp;atilde;o capaz de manter 50% da viabilidade celular, atrav&amp;eacute;s do ensaio de citotoxicidade em c&amp;eacute;lulas MRC-5 (fibroblasto pulmonar humano). Determinou-se o &amp;iacute;ndice de seletividade (IS) que representa quanto um composto &amp;eacute; mais seletivo para a morte do microrganismo sem causar dano celular. Objetivo: Avalia&amp;ccedil;&amp;atilde;o do potencial anti-MTB dos ligantes hino e trop, seus complexos com Pd e Pt e seus precursores. Metodologia: Tanto o REMA, para determinar a CIM90, quanto o ensaio de citotoxicidade para determinar o IC50, s&amp;atilde;o m&amp;eacute;todos de microdilui&amp;ccedil;&amp;atilde;o em placas de 96 po&amp;ccedil;os que utilizam a resazurina como revelador. O in&amp;oacute;culo bacteriano utilizado foi de aproximadamente 105 UFC/mL e o intervalo de concentra&amp;ccedil;&amp;otilde;es foi 25 - 0,098&amp;mu;g/mL. Para o ensaio de citotoxicidade o intervalo de concentra&amp;ccedil;&amp;otilde;es utilizado foi de 100 - 0,39&amp;mu;g/mL. Para demostrar o IS, calculou-se a divis&amp;atilde;o dos valores obtidos de IC50/MIC. Resultados e discuss&amp;atilde;o: Com os resultados do REMA n&amp;oacute;s observamos que a atividade anti-MTB de hino (35.46&amp;mu;M) e trop (29.02&amp;mu;M) sozinhos foram menos ativos que quando complexados com Pd e Pt. Encontramos entre Pd-hino (13.14&amp;mu;M), Pd-trop (9.01&amp;mu;M), Pt-hino (14.73&amp;mu;M), Pt-trop (17.60&amp;mu;M), que Pd-trop &amp;eacute; o mais ativo. J&amp;aacute; os melhores valores de IS foram para trop (7,02) e hino (7,03), pois os ligantes sozinhos s&amp;atilde;o menos t&amp;oacute;xicos para as c&amp;eacute;lulas. Nos isolados cl&amp;iacute;nicos n&amp;oacute;s observamos que a atividade foi menor que contra a cepa sens&amp;iacute;vel (H37Rv), mas ainda observamos atividade para trop and Pd-trop confirmando o seu potencial anti-MTB, pois, trop apresentou atividade contra 3 cepas (18,30-99,44&amp;mu;M) e Pd-trop contra 2 (9,05-25,64&amp;mu;M) das 4 cepas testadas. Conclus&amp;atilde;o: Esses dados demonstram que os ligantes hino e trop apresentam atividade anti-MTB, mas a complexa&amp;ccedil;&amp;atilde;o com Pd e Pt melhora esta atividade. No entanto, a complexa&amp;ccedil;&amp;atilde;o com os metais levou a um aumento na citotoxicidade, apenas hino e trop, quando n&amp;atilde;o complexados, apresentaram IS superiores a 7 enquanto os complexos apresentaram IS menor que 2. A pesquisa de novas mol&amp;eacute;culas &amp;eacute; uma necessidade, visto o aumento da resist&amp;ecirc;ncia aos antibi&amp;oacute;ticos dispon&amp;iacute;veis.</text>
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                <text>&lt;strong&gt;Souza Silva, Ana Paula&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mar&amp;iacute;ngolo Ribeiro, Camila&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Rivas, Feriannys&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Solcia, Mar&amp;iacute;a Cristina&lt;/strong&gt;</text>
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                <text>&lt;a title="Curiculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=2ff5755f42707a83e7aea75299e5667c" target="_blank"&gt;&lt;strong&gt;Gambino, Dinorah.&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Pavan, Fernando Rog&amp;eacute;rio&lt;/strong&gt;</text>
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                <text>Revista de Ciencias Farmaceuticas Basica e Aplicada Araraquar&amp;aacute; v. 38, suppl. 1, 2017. -- 1p.-</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
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                <text>This work aimed to find a rational nutrient feeding strategy for cider vinegar fermentation based on adequate information on the nutritional requirement of acetic acid bacteria. Through single nutrient lack experiment assay, necessary nutrient recipe for Acetobacter pasteurianus CICIM B7003 in acetous fermentation was confirmed. Compounds from the essential nutrient recipe were tested further to find out the key substrates significantly influencing cider vinegar fermentation. The findings showed that aspartate, glutamate, proline and tryptophan should be considered in detail for optimizing nutritional composition of cider. Finally, a nutrient feeding strategy that simultaneously adds proline, glutamate, aspartate and tryptophan to form final concentrations of 0.02 g/L, 0.03 g/L, 0.01 g/L and 0.005 g/L in cider was achieved by orthogonal experiment design. Comparing to the original fermentation, the yield of acetic acid from alcohol reached 93.3% and the concentration of most volatile flavor compounds increased with the rational nutrient feeding strategy.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Influence of sociodemographic characteristics on different dimensions of household food insecurity in Montevideo, Uruguay&lt;/strong&gt;</text>
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                <text>To determine the factor structure of the Latin American &amp;amp; Caribbean Household Food Security Scale (ELCSA) and to study the influence of sociodemographic characteristics on each of the identified dimensions in Montevideo, Uruguay. Cross-sectional survey with a representative sample of urban households. Household food insecurity was measured using the ELCSA. The percentage of respondents who gave affirmative responses for each of the items of the ELCSA was determined. Exploratory factor analysis was carried out to determine the ELCSA&amp;rsquo;s factor structure. A probit model was used to determine the impact of some individual and household sociodemographic characteristics on the identified dimensions of food insecurity. Metropolitan area centred on Montevideo, the capital city of Uruguay, April&amp;ndash;September 2014. Adults aged between 18 and 93 years (n 742). The percentage of affirmative responses to the items of the ELCSA ranged from 4&amp;middot;4 to 31&amp;middot;7 %. Two factors were identified in the exploratory factor analysis performed on data from households without children under 18 years old, whereas three factors were identified for households with children. The identified factors were associated with different severity levels of food insecurity. Likelihood of experiencing different levels of food insecurity was affected by individual characteristics of the respondent as well as characteristics of the household. The influence of sociodemographic variables varied among the ELCSA dimensions. Household income had the largest influence on all dimensions, which indicates a strong relationship between income and food insecurity.</text>
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                <text>&lt;strong&gt;Rossi, M&amp;aacute;ximo&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Ferre, Zuleika&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Curutchet, Mar&amp;iacute;a Rosa&lt;/strong&gt;</text>
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                <text>Public Health Nutrition&amp;nbsp; v. 20, no. 4, 2017. -- p. 620-629</text>
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                <text>Cambridge</text>
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              <elementText elementTextId="463286">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>DOI: 10.1017/S1368980016002548</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans&lt;/strong&gt;</text>
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                <text>PROTEINAS</text>
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                <text>SELENOPROTEINAS</text>
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                <text>BACTERIAS PATOGENAS</text>
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                <text>2017</text>
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                <text>Selenoprotein T (SELENOT) is an endoplasmatic reticulum (ER)-associated redoxin that contains the amino acid selenocysteine (Sec, U) within a CXXU motif within a thioredoxin-like fold. Its precise function in multicellular organisms is not completely understood although it has been shown in mammals to be involved in Ca2+ homeostasis, antioxidant and neuroendocrine functions. Here, we use the model organism C. elegans to address SELENOT function in a whole organism throughout its life cycle. C. elegans possess two genes encoding SELENOT protein orthologues (SELT-1.1 and SELT-1.2), which lack Sec and contain the CXXC redox motif instead. Our results show that a Sec&amp;rarr;Cys replacement and a gene duplication were two major evolutionary events that occurred in the nematode lineage. We find that worm SELT-1.1 localizes to the ER and is expressed in different cell types, including the nervous system. In contrast, SELT-1.2 exclusively localizes in the cytoplasm of the AWB neurons. We find that selt-1.1 and selt-1.2 single mutants as well as the double mutant are viable, but the selt-1.1 mutant is compromised under rotenone-induced oxidative stress. We demonstrate that selt-1.1, but not selt-1.2, is required for avoidance to the bacterial pathogens Serratia marcescens and Pseudomonas aeruginosa. Aversion to the noxious signal 2-nonanone is also significantly impaired in selt-1.1, but not in selt-1.2 mutant animals. Our results suggest that selt-1.1 would be a redox transducer required for nociception and optimal organismal fitness. The results highlight C. elegans as a valuable model organism to study SELENOT-dependent processes.</text>
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                <text>&lt;strong&gt;Romanelli Cedrez, Laura.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Carrera, In&amp;eacute;s&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Miranda Vizuete, Antonio&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Mariotti, Marco&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Alkema, Mark J.&lt;/strong&gt;</text>
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                <text>Free Radical Biology and Medicine v. 108, 2017. -- p. 174-182</text>
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              <elementText elementTextId="463239">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor &lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The Pechini sol-gel method has been employed for the synthesis of pure and (181Hf&amp;rarr;)181Ta-doped Y2O3 nanopowders. We performed a structural characterization from the micro to the subnanoscopic scale by means of scanning electron microscopy, energy dispersive x-ray spectroscopy, x-ray diffraction, and time-differential perturbed &amp;gamma;&amp;ndash;&amp;gamma; angular correlation (PAC) spectroscopy. The results show the formation of the cubic bixbyite structure after a thermal treatment at 1473 K. For the synthesized 181Ta-doped Y2O3, the PAC experiments demonstrate that the impurities are mainly located at both substitutional cationic sites of the bixbyite structure. The experimental investigation was complemented by performing first-principles electronic structure calculations for Ta atoms localized at the two cationic sites of the Y2O3 semiconductor structure, which allow the study of the structural and electronic modifications induced in the host system when the impurities are introduced. These calculations confirm that the measured electric-field gradients for the synthesized 181Ta-doped Y2O3 correspond to double-ionized impurities located at substitutional defect-free cationic sites of the bixbyite host structure and indicate the site occupancy preference for 181Hf(&amp;rarr;181Ta) doping. The behaviour of the site preference of 181Ta impurities with temperature is also discussed. In addition to an extensive structural and electronic characterization of pure and Ta-doped Y2O3 semiconductor, our results demonstrate that the Pechini sol-gel process is an affordable and effective way to successfully synthesize these PAC substitutional doped samples.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;The role of information on consumer sensory, hedonic and wellbeing perception of sugar-reduced products : Case study with orange/pomegranate juice&lt;/strong&gt;</text>
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                <text>Reformulation of industrialized products has been recognized as one of the most effective strategies to reduce sugar intake and improve public health. Information about product reformulation can negatively affect consumer hedonic perception as a negative relationship between tastiness and healthfulness exists. In this context, the aim of the present study was to investigate the effect of information about sugar reduction and the use of sweeteners on consumer hedonic, sensory and wellbeing perception, using orange/pomegranate as case study. Samples of orange/pomegranate juice with different sweeteners (no added sugar, sugar, sucralose, stevia and monk fruit extract) were evaluated by 196 consumers under blind or informed conditions, following a between-subjects experimental design. Consumers in the informed group were presented the juice samples with their corresponding bottle displayed on a computer screen, including information about sugar content using the traffic-light system, claims on no added sugar and the presence of natural sweeteners. Consumers had to evaluate their overall liking and answer two CATA questions, related to sensory and wellbeing perception. Information increased consumer sensory and hedonic discrimination of the samples, particularly for the juice sweetened with stevia. Information influenced consumer perception of physical health and emotional aspects of wellbeing. Results from the present work suggest that the influence of information about nutritional characteristics of products and reformulation strategies seems to be modulated by the degree of difference between consumers&amp;rsquo; sensory perception of reformulated products and their regular counterpart.</text>
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                <text>&lt;strong&gt;Reis, Felipe&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Alcaire, Florencia.&lt;/strong&gt;</text>
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                <text>Food Quality and Preference&amp;nbsp; v. 62, 2017. -- p. 227-236</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1016/j.foodqual.2017.06.005</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>POLIMEROS DE COORDINACION</text>
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                <text>PROPIEDADES FISICOQUIMICAS</text>
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                <text>MIOINOSITOL</text>
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                <text>myo‐Inositol phosphates are an important group of biomolecules that are present in all eukaryotic cells. The most abundant member of this family in nature is InsP6 (phytate, L12&amp;minus; in its fully deprotonated form). Phytate interacts strongly with inorganic and organic cations, and this interaction is essential for determining the possible functions of this biomolecule. Herein, the chemical, thermodynamic, and structural characterization of phytate&amp;ndash;MnII species is presented in a study aimed at understanding how the interaction of the two components modulates their biological roles and their bioavailability. Polynuclear complexes Mn5(H2L)&amp;sdot;16&amp;thinsp;H2O (1) and (H2terpy)2[Mn(H6L)(terpy)(H2O)]&amp;sdot;17&amp;thinsp;H2O (terpy=terpyridine) (2) were prepared and characterized by different techniques. The isolation of 1 and the determination of its solubility, together with potentiometric titrations of the MnII&amp;ndash;phytate system, allow the full description of this binary system. The preparation and crystal structure of 2 show a novel coordination mode of phytate, that is, the formation of infinite polymeric chains through equatorial phosphate groups.</text>
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                <text>&lt;strong&gt;Qui&amp;ntilde;one, Delfina&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=f31ba94f764507db0d42d457038dd734" target="_blank"&gt;&lt;strong&gt;Veiga, Nicolas&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b1b8a8c8b1a5835b874ac1994003c38d" target="_blank"&gt;&lt;strong&gt;Torres, Julia&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>&lt;strong&gt;Bazzicalupi, Carla&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Bianchi, Antonio&lt;/strong&gt;</text>
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                <text>ChemPlusChem&amp;nbsp; v. 82, no. 5, 2017. -- p. 721-731</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Journal of Apicultural Research |g v. 56, no. 5, 2017. -- p. 616-624</text>
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                <text>Taylor &amp;amp; Francis</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1080/00218839.2017.1348714</text>
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                  <text>Bibliografía Nacional Química</text>
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              <description>An account of the resource</description>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Mechanical properties and electronic structure of edge doped graphene nanoribbons with F, O and Cl atoms&lt;/strong&gt;</text>
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                <text> NANOTECNOLOGIA</text>
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                <text> GRAFENO</text>
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                <text>PROPIEDADES MECANICAS</text>
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                <text>In this study, we present the structural, electronic, and mechanical properties of edge-doped zigzag graphene nanoribbons (ZGNRs) doped with fluorine, oxygen, and chlorine atoms. To the best of our knowledge, to date, no experimental results concerning the mechanical properties of graphene-derived nanoribbons have been reported in the literature. Simulations indicate that Cl- and F-doped ZGNRs present an equivalent 2-dimensional Young's modulus E2D, which seems to be higher than those of graphene and H-doped ZGNRs. This is a consequence of the electronic structure of the system, particularly originating from strong interactions between the dopant atoms localized at the edges. The interaction between dopant atoms located at the edges is higher for Cl and lower for F and O atoms. This is the origin of the observed trend, in which E2DCl &amp;gt; E2DF &amp;gt; E2DO for all the analyzed ZGNRs.</text>
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                <text>&lt;strong&gt;Piriz, Sebasti&amp;aacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fern&amp;aacute;ndez Werner, Luciana&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Jasen, Paula&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=fc7cd71892b1a9968ee19230dafdbd01" target="_blank"&gt;&lt;strong&gt;Faccio, Ricardo&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Physical Chemistry Chemical Physics |g v. 19, no. 32, 2017. -- p. 21474-21480</text>
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                <text>Royal Society of Chemistry</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>CIANOBACTERIAS</text>
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                <text>Owing to their reproducibility, stability, and cost-effective production, the recombinant variable domains of heavy-chain-only antibodies (VHHs) are becoming a salient option as immunoassay reagents. Recently, there have been several reports describing their application to the detection of small molecules (haptens). However, lacking the heavy-light chain interface of conventional antibodies, VHHs are not particularly apt to bind small analytes and failures are not uncommon. Here we describe the construction of a VHH phage display library against the cyanobacterial hepatotoxin microcystin LR and its selection using competitive panning and two novel panning strategies. The outcome of each strategy was evaluated by a large-scale screening using in vivo biotinylated nanobodies. The three methods selected for different nonoverlapping subsets of VHHs, allowing one to optimize the immunodetection of the toxin. The best results were obtained by promoting the isolation of VHHs with the slowest koff (off-rate selection). Among these, the biotinylated nanobody A2.3 performed in ELISA with excellent recovery and high sensitivity, IC50 = 0.28 &amp;mu;g/L, with a limit of detection that is well below the most rigorous guidelines for the toxin. While it may be case-specific, these results highlight the importance of exploring different panning strategies to optimize the selection of antihapten nanobodies.</text>
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                <text>&lt;strong&gt;Badagian, Natalia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gonz&amp;aacute;lez Sapienza, Gualberto.&lt;/strong&gt;</text>
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                <text>Analytical Chemistry&amp;nbsp; v. 89, no. 12, 2017. -- p. 6800-6806</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1021/acs.analchem.7b01221</text>
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                <text>&lt;strong&gt;Chemical Composition, Antimicrobial Activity, and Mode of Action of Essential Oils against Paenibacillus larvae, Etiological Agent of American Foulbrood on Apis mellifera&lt;/strong&gt;</text>
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                <text>MICROBIOLOGIA</text>
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                <text>This study aimed to characterize the chemical composition of Aloysia polystachia, Acantholippia seriphioides, Schinus molle, Solidago chilensis, Lippia turbinata, Minthostachys mollis, Buddleja globosa, and Baccharis latifolia essential oils (EOs), and to evaluate their antibacterial activities and their capacity to provoke membrane disruption in Paenibacillus larvae, the bacteria that causes the American Foulbrood (AFB) disease on honey bee larvae. The relationship between the composition of the EOs and these activities on P. larvae was also analyzed. Monoterpenes were the most abundant compounds in all EOs. All EOs showed antimicrobial activity against P. larvae and disrupted the cell wall and cytoplasmic membrane of P. larvae provoking the leakage of cytoplasmic constituents (with the exception of B. latifolia EO). While, the EOs&amp;rsquo; antimicrobial activity was correlated most strongly to the content of pulegone, carvone, (Z)-&amp;beta;-ocimene, &amp;delta;-cadinene, camphene, terpinen-4-ol, elemol, &amp;beta;-pinene, &amp;beta;-elemene, &amp;gamma;-cadinene, &amp;alpha;-terpineol, and bornyl acetate; the volatiles that better explained the membrane disruption were carvone, limonene, cis-carvone oxide, pentadecane, trans-carvyl acetate, trans-carvone oxide, trans-limonene oxide, artemisia ketone, trans-carveol, thymol, and &amp;gamma;-terpinene (positively correlated) and biciclogermacrene, &amp;delta;-2-carene, verbenol, &amp;alpha;-pinene, and &amp;alpha;-thujene (negatively correlated). The studied EOs are proposed as natural alternative means of control for the AFB disease.</text>
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                <text>&lt;strong&gt;Pellegrini, Mar&amp;iacute;a Celeste&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Alonso Salces, Rosa Mar&amp;iacute;a&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Fuselli, Sandra Rosa&lt;/strong&gt;</text>
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                <text>Chemistry and Biodiversity v. 14, no. 4, 2017. --44p. -- e 1600382</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;( p -Allyl)palladium coupling of 2-(tributylstannyl)cyclopent-2-enone for the synthesis of jasmonoid analogs&lt;/strong&gt;</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="462991">
                <text>SINTESIS</text>
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                <text>PALADIO</text>
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                <text> JASMINOIDES</text>
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              <elementText elementTextId="462994">
                <text>ANALOGOS</text>
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              <elementText elementTextId="462995">
                <text> BIBLIOGRAFIA NACIONAL QUIMICA</text>
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              <elementText elementTextId="462996">
                <text>2017</text>
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          <element elementId="87">
            <name>Abstract</name>
            <description>A summary of the resource.</description>
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                <text>The coupling of 2-(tributylstannyl)cyclopent-2-enone with several (&amp;pi;-allyl)palladium complexes derived from allylic electrophiles was investigated as the key step in the synthesis of jasmonoids. These compounds have an important role in plant development, triggering direct and indirect responses when harmed to induce pest resistance. Palladium-catalyzed coupling conditions to obtain a jasmonoid library are described. The retention of geometry of the olefin in the allyl group is not always observed due to syn-anti isomerization of the (&amp;pi;-allyl)palladium complex. The methodology was employed for the synthesis of a simplified jasmonic acid analog.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>&lt;strong&gt;Parpal, Florencia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Heguaburu, Viviana&lt;/strong&gt;</text>
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                <text>&lt;a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1ad085b4305ec8d8997ce8a565b947d4" target="_blank"&gt;&lt;strong&gt;Pandolfi, Enrique&lt;/strong&gt;&lt;/a&gt;</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="463001">
                <text>Tetrahedron Letters |g v. 58, 2017. -- p. 1965-1968</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="463002">
                <text>Elsevier</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="463003">
                <text>2017</text>
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            </elementTextContainer>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="463004">
                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="463005">
                <text>PDF</text>
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          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="463006">
                <text>Ingl&amp;eacute;s</text>
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          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Art&amp;iacute;culo</text>
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                <text>DOI: 10.1016/j.tetlet.2017.04.018</text>
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        <name>Analogos</name>
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        <name>Jasminoide</name>
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        <name>Paladio</name>
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        <name>Síntesis</name>
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