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                <text>During the iodoetherification of chiral and conformationally restricted 3‐butenyl carbinols to give 2,5‐disubstituted THFs, the presence of an ester in the side chain exerts a profound effect on the chemo‐ and diastereoselectivity of the reaction. When submitted to standard iodoetherification conditions, ester‐containing substrates gave diastereomeric mixtures of THFs, together with variable amounts of iodohydrins. Conversely, when the ester group was reduced to an alcohol or ether, the corresponding trans‐THFs were obtained more quickly, with complete diastereoselectivity and without contamination by the iodohydrin. In this paper, the mechanistic details of the iodoetherification of protected 3‐butenyl carbinols are revealed. The results show that the carbonyl group decreases the nucleophilicity of the acetonide oxygen atoms, and stabilizes the reactants by a carbonyl&amp;ndash;iodonium through‐space interaction. Additionally, it promotes the formation of a stable seven‐membered‐ring carboxonium intermediate, causing an increase in the activation barriers and a decrease in the reaction diastereoselectivity compared to the non‐ester analogues.</text>
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                <text>European Journal of Organic Chemistry&amp;nbsp; no. 26, 2017. -- p. 3856-3864</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1002/ejoc.201700494</text>
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                <text>&lt;strong&gt;Diels-Alder Reaction of Levoglucosenone with a Protected cis-Cyclohexadienediol : |b Structural and Electronic Basis behind the Unexpected Stereoselectivity&lt;/strong&gt;</text>
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                <text>Recently, we found that the Diels&amp;ndash;Alder reaction between levoglucosenone and the acetonide of (1S,2R)‐3‐methylcyclohexa‐3,5‐diene‐1,2‐diol occurs through the most hindered face of the diene. This unexpected facial selectivity has no precedent for di‐O‐isopropylidene‐protected dienes, and the reasons behind it remain unclear. Here, we expand on our earlier findings, computationally assessing the structural and electronic factors responsible for this unforeseen stereoselectivity. The B3LYP/6‐31+G(d,p) results identify the three main adducts (&amp;beta;‐endo‐ortho:&amp;alpha;‐endo‐meta:&amp;alpha;‐exo‐ortho), giving a product ratio (63:9:28) that is in line with the experimental value (64:16:10). The &amp;beta;‐endo attack allows to maximize the electrostatic attraction between the reactants, giving rise to dipolar C&amp;minus;O&amp;sdot;&amp;sdot;&amp;sdot;H&amp;minus;C interactions with the isopropylidene group at the transition state. The endo/exo preference can be rationalized through electrostatic repulsion and steric hindrance between the isopropylidene and methylene fragments. Finally, the non‐classical C=O&amp;sdot;&amp;sdot;&amp;sdot;H&amp;minus;C hydrogen bonding stabilizes the ortho transition structures, making them more polar and asynchronous.</text>
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                <text>&lt;strong&gt;Mart&amp;iacute;nez, Sebasti&amp;aacute;n&lt;/strong&gt;</text>
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                <text>ChemistrySelect&amp;nbsp; v. 2, 2017. -- p. 11223-11230</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Disponer de un m&amp;eacute;todo de transesterificaci&amp;oacute;n de aceites eficiente en presencia de agua resultar&amp;iacute;a del mayor inter&amp;eacute;s con vistas a la utilizaci&amp;oacute;n de alcohol rectificado en lugar del metanol utilizado tradicionalmente para dicho fin. En este trabajo, se estudi&amp;oacute; el efecto sobre la eficiencia de la transesterificaci&amp;oacute;n en continuo en etanol supercr&amp;iacute;tico de los diferentes par&amp;aacute;metros operativos, entre ellos el contenido de agua del alcohol. Los resultados indican que el proceso de conversi&amp;oacute;n en biodiesel de los aceites de soja, girasol, girasol alto oleico y ricino puede realizars con relativa alta eficiencia si eligen convenientemente los par&amp;aacute;metros operativos. Sin embargo, se encontr&amp;oacute; que el material lip&amp;iacute;dico sometido a las condiciones extremas de temperatura y presi&amp;oacute;n requeridas sufri&amp;oacute; un grado de deterioro significativo, produciendo la reducci&amp;oacute;n del porcentaje de los &amp;aacute;cidos grasos insaturados, fen&amp;oacute;meno que aparece como la principal limitante del contenido de &amp;eacute;ster del producto. En este trabajo se muestran los resultados mas representativos de la tesis de Doctorado de Ignacio Vietez, (2010, Facultad de Qu&amp;iacute;mica, Udelar)</text>
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                <text>Eco_l&amp;oacute;gicas: Concurso Mercosur de Monografias sobre Energ&amp;iacute;as Renovables y Eficiencia Energ&amp;eacute;tica: Trabajos presentados / Instituto para el Desarrollo de Energ&amp;iacute;as Alternativas em Latinoam&amp;eacute;rica. Florian&amp;oacute;polis : Quorum Comunica&amp;ccedil;ao, 2012. p. 111-131</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The space group of a crystal pattern is the intersection group of the eigensymmetries of the crystallographic orbits corresponding to the occupied Wyckoff positions. Polar space groups without symmetry elements with glide or screw components smaller than 1/2 do not contain characteristic orbits and cannot be realized in patterns (structures) made by only one crystallographic type of object (atom). The space-group diagram of the general orbit for this type of group has an eigensymmetry that corresponds to a special orbit in a centrosymmetric supergroup of the generating group. This fact is often overlooked, as shown in the proposed solution for Plates (i)&amp;ndash;(vi) of IUCr Teaching Pamphlet No. 14, and an alternative interpretation is given</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>wo-component mixtures of candesartan cilexetil (CAN) and hydrochlorothiazide (HYD) were assayed by first derivative and ratio derivative spectrophotometry. The first method depends on zero-crossing and peak to base measurement. The first derivative amplitudes at 270.1 and 255.5 nm were selected for the assay of (CAN) and (HYD), respectively. The second method depends on first derivative of the ratio spectra by division of the absorption spectrum of the binary mixture by a normalized spectrum of one of the components and then calculating the first derivative of the ratio spectrum. The first derivative of the ratio amplitudes at 236, 250, 232, 267 and 280 nm were selected for the determination of (CAN) and (HYD), respectively. Calibration curves were established for 6.0-38.0 microg x ml(-1) for (CAN) and 4.0-28.0 microg x ml(-1) for (HYD) in binary mixtures. Good linearity, precision and selectivity were found, and the two methods were successfully applied to the pharmaceutical dosage form containing the above-mentioned drug combination without any interference by the excipients.</text>
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                <text>During malolactic fermentation (MLF), lactic acid bacteria influence aroma and flavor of wines by the production of volatile metabolites and the modification of aroma compounds derived from grapes and yeasts. In an effort to isolate these bacteria properties as advantages for winemaking, this study aimed to assess the relative contribution of two aspects: the effects of lactic acid bacteria activity on the volatiles compounds in Tannat wines and the consequences of aging in bottle on aroma compounds produced during MLF. To our knowledge, this is the first report related to the effect of wine aging in bottle on the aroma chemical compounds produced by MLF. Solid phase extraction complemented with chromatographic techniques was used to study the wine aroma compounds. A sensory evaluation of the wines was also performed through descriptive methods. We demonstrated modifications in the concentration of acetates, ethyl esters, and other secondary metabolites during MLF. Major sensorial differences between wines that had undergone MLF were also noted. In addition, some modifications detected in the composition of Tannat wines as a consequence of the aging in bottle contributed to the change in differences between wines with and without MLF and furthermore between strains. These changes probably influence its fruity character.</text>
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                <text>Journal of Agricultural and Food Chemistry |g v. 57, no.14, 2009. -- p.6271-6278</text>
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&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Natural Product Communications v. 4, no. 6, 2009. -- p.853-858</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt; ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A new method was developed for analysing 4-ethylguaiacol and 4-ethylphenol in the aroma of red wines using dispersive liquid&amp;ndash;liquid microextraction (DLLME) coupled with gas chromatography&amp;ndash;mass spectrometry detection (GC&amp;ndash;MS). Parameters such as extraction solvent, sample volume and disperser solvent were studied and optimised to obtain the best extraction results with the minimum interference from other substances, thus giving clean chromatograms. The response linearity was studied in the usual concentration ranges of analytes in wines (50&amp;ndash;1500 �g/L). Repeatability and reproducibility of this method were lower than 5% for both volatile phenols. Limits of detection and limits of quantification were also determined, and the values found were 28 and 95 �g/L for 4-ethylguaiacol and 44 and 147 �g/L for 4-ethylphenol, respectively. This new method has been used for the determination of the volatile phenols concentration in different samples of Tannat wine affected by Brettanomyces contamination.</text>
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                <text>Mammalian cells contain a pool of iron that is not strongly bound to proteins, which can be detected with fluorescent chelating probes. The cellular ligands of this biologically important &amp;lsquo;&amp;lsquo;chelatable&amp;rsquo;&amp;rsquo;, &amp;lsquo;&amp;lsquo;labile&amp;rsquo;&amp;rsquo; or &amp;lsquo;&amp;lsquo;transit&amp;rsquo;&amp;rsquo; iron are not known. Proposed ligands are problematic, because they are saturated by magnesium under cellular conditions and/or because they are not &amp;lsquo;&amp;lsquo;safe&amp;rsquo;&amp;rsquo;, i.e. they allow iron to catalyse hydroxyl radical formation. Among small cellular molecules, certain inositol phosphates (InsPs) excel at complexing Fe3? in such a &amp;lsquo;&amp;lsquo;safe&amp;rsquo;&amp;rsquo; manner in vitro. However, we previously calculated that the most abundant InsP, inositol hexakisphosphate, cannot interact with Fe3? in the presence of cellular concentrations of Mg2?. In this work, we study the metal complexation behaviour of inositol 1,2,3-trisphosphate [Ins(1,2,3)P3], a cellular constituent of unknown function and the simplest InsP to display high-affinity, &amp;lsquo;&amp;lsquo;safe&amp;rsquo;&amp;rsquo;, iron complexation. We report thermodynamic constants for the interaction of Ins(1,2,3)P3 with Na?, K?, Mg2?, Ca2?, Cu2?, Fe2? and Fe3?. Our calculations indicate that Ins(1,2,3)P3 can be expected to complex all available Fe3? in a quantitative, 1:1 reaction, both in cytosol/nucleus and in acidic compartments, in which an important labile iron subpool is thought to exist. In addition, we calculate that the fluorescent iron probe calcein would strip Fe3? from Ins(1,2,3)P3 under cellular conditions, and hence labile iron detected using this probe may include iron bound to Ins(1,2,3)P3. Therefore Ins(1,2,3)P3 is the first viable proposal for a transit iron ligand.</text>
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                <text>&lt;strong&gt;Mansell, David.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Freeman, Sally.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Dominguez, Sixto.&lt;/strong&gt;</text>
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                <text>Journal of Biological Inorganic Chemistry v. 14, no. 1, 2009. -- p. 51-59</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>In the present work, we developed robust processes for the preparation of new antitrypanosomal benzofuroxans, E and Z isomers of 5-arylethenylbenzo[1,2- c]1,2,5-oxadiazole N 1-oxide 1&amp;ndash; 6, in multigram batch through Wittig&amp;minus;Boden conditions as the key synthetic step. In these conditions, the generation of the benzofurazans, as secondary byproduct, was minimized.</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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                <text>The aim of the study was to evaluate the antifungal activity of extracts of 10 plant species used in traditional Uruguayan medicine against the phytopathogenic fungus Alternaria spp. The plants were selected on the basis of their reported ethnobotanical uses. Aqueous, saline buffer and acid extracts of different plant species were screened in vitro for their antifungal activity against Alternaria spp. For the antifungal evaluation we used a microspectrophotometric assay. Minimal inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the extracts were determined. Three solvents were assayed on different tissues of the plants and among the 29 evaluated extracts, 31% of the extracts inhibited growth, similar to the effects of a chemical fungicide. Acid extracts of the plants were more effective than the aqueous or buffer extracts against Alternaria spp. The MIC values of the extracts were determined ranging between 1.25 and 25 &amp;mu;g mL-1. The MFC values of the extracts ranged between 1.25 &amp;mu;g mL-1 (Rosmarinus officinalis L.) and 10 &amp;mu;g mL-1 (Cynara scolymus L.). MICs and MFCs values obtained from leaves (Salvia officinalis L. and R. officinalis) and seeds extracts (Salvia sclarea L.) were quite comparable to values obtained with the conventional fungicide captan (2.5 &amp;mu;g mL-1). The extracts of Salvia sclarea, S. officinalis and R. officinalis could be considered as potential sources of antifungal compounds for treating diseases in plants. These extracts showed maximum activity, even at very low concentrations, and the same fungicide effects as chemical fungicide. We conclude from this that these extracts exhibit amazing fungicidal properties that support their traditional use as antiseptics</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>A glycoconjugate constituted by the Streptococcus pneumoniae serotype 14 capsular polysaccharide (CPS14) and bovine serum albumin (BSA) was prepared, and the unique properties of Sephadex LH-20 were used to separate the conjugate from the unconjugated material. The strength of this approach consists in its capacity to produce pure polysaccharide&amp;ndash;protein conjugate in good yield and free from unconjugated material, a common residual contaminant of this type of immunobiologicals. The CPS14&amp;ndash;BSA conjugate prepared via an improved 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP)-activation technique was characterized chemically and its immunogenicity was evaluated in mice. The purified conjugate, unlike the corresponding polysaccharide, produced a T-cell-dependent response in this species.</text>
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                <text>Arbitrarily defined as organic salts with melting points below 1001C, ionic liquids (ILs) have gained considerable notoriety in the past decade. Owing to their negligible vapor pressure, thermal stability, and tunable solvent properties, these materials have found applications in a wide range of laboratory and industrial processes.1 As part of efforts aimed at better understanding the liquid structure of imidazolium-based ILs, we have shown that intraionic hydrogen-bonding (H-bonding) interactions in 1-n-butyl-3-methylimidazolium chloride ([C4mim]Cl (1), Figure 1) are evidenced by sizable deuterium isotope effects on the chloride ion 35/37Cl NMR signal (i.e. D35/37Cl(H,D)).2 Measurements obtained on the [C4mim]Cl isotopologues [2-d1]-[C4mim]Cl and [2,4,5-d3]-[C4mim]Cl led to D35/37Cl(H,D) values of up to 2 ppm, and corroborated the presence of H-bonds between the anion and the imidazolium cation protons on the C-2, C-4, and C-5 positions. Recent theoretical studies indicate that H-bonding between the anion and protons along the N-alkyl groups could also have an impact on the structure and dynamics of this class of ILs.3,4 Based on our previous results, these anion&amp;ndash;cation interactions could be detected experimentally by measurement of deuterium isotope effects on the 35/37Cl NMR signal of the chloride ion. For this purpose, we decided to synthesize a series of [C4mim]Cl deuterium isotopologues sequentially labeled along the N-alkyl group carbons (Figure 1a&amp;ndash;e). These could also be easily converted by metathesis to the corresponding tetrafluoroborate and hexafluorophosphate imidazolium salts (i.e. [C4mim]BF4 and [C4mim]PF6), which would be suitable for the study of interionic H-bonds through analysis of deuterium isotope effects on the 10/11B, 19F, and 31P signals of the BF! 4 and BF! 6 anions. In this manuscript we describe a strategy which uses similar routes to minimize the number of distinct reactions needed to prepare these compounds. As detailed below, good yields after the initial deuterium incorporation reaction were achieved in several cases through the combination of well-established chemical transformations into efficient single-step processes.</text>
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                <text>&lt;strong&gt;Khrizman, Alexander&lt;/strong&gt;</text>
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                <text>Journal of Labelled Compounds and Radiopharmaceuticals v. 54, no. 8. -- p. 401-407</text>
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                <text>Wiley &amp;amp; Sons</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>The photoisomerization of the Diels&amp;ndash;Alder adduct formed between tetramethylpurpurogallin and maleic anhydride is described. The process is highly stereoselective, involves the b,c-unsaturated ketone chromophore present in the adduct, proceeds through 15 the formation of allyl and aroyl radical intermediates, and leads to a novel substituted dihydrofluorenone in good yields.</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
&lt;p&gt;(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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