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                  <text>Bibliografía Nacional Química</text>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                <text>&lt;strong&gt;Untargeted metabolomics of 3xTg-AD neurotoxic astrocytes&lt;/strong&gt;</text>
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                <text>ENFERMEDAD DE ALZHEIMER</text>
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                <text>RATONES 3x-Tg-AD</text>
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                <text>Alzheimer’s disease (AD) is the most common form of dementia, affecting approximately 47 M people worldwide. Histological features and genetic risk factors, among other evidence, supported the amyloid hypothesis of the disease. This neuronocentric paradigm is currently undergoing a shift, considering evidence of the role of other cell types, such as microglia and astrocytes, in disease progression. Previously, we described a particular astrocyte subtype obtained from the 3xTg-AD murine model that displays neurotoxic properties in vitro. We continue here our exploratory analysis through the lens of metabolomics to identify potentially altered metabolites and biological pathways. Cell extracts from neurotoxic and control astrocytes were compared using high-resolution mass spectrometrybased metabolomics. Around 12 % of metabolic features demonstrated significant differences between neurotoxic and control astrocytes, including alterations in the key metabolite glutamate. Consistent with our previous transcriptomic study, the present results illustrate many homeostatic and regulatory functions of metabolites, suggesting that neurotoxic 3xTg-AD astrocytes exhibit alterations in the Krebs cycle as well as the prostaglandin pathway.This is the first metabolomic study performed in 3xTg-AD neurotoxic astrocytes. These results provide insight into metabolic alterations potentially associated with neurotoxicity and pathology progression in the 3xTg-AD mouse model and strengthen the therapeutic potential of astrocytes in AD. Biological significance: Our study is the first high-resolution metabolomic characterization of the novel neurotoxic 3xTg-AD astrocytes. We propose key metabolites and pathway alterations, as well as possible associations with gene expression alterations in the model. Our results are in line with recent hypotheses beyond the amyloid cascade, considering the involvement of several stress response cascades during the development of Alzheimer’s disease. This work could inspire other researchers to initiate similar studies in related models. Furthermore, this work illustrates a powerful workflow for metabolite annotation and selection that can be implemented in other studies.</text>
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                <text>&lt;strong&gt;Carvalho, Diego&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Arredondo Unanua, María Florencia&lt;/strong&gt;</text>
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                <text>Journal of Proteomics, v.310, 2025. -- e105336</text>
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&lt;p&gt;&lt;strong&gt;Información sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;La legislación uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;
&lt;/div&gt;</text>
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                <text>10.1016/j.jprot.2024.105336</text>
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        <name>Astrocitos</name>
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        <name>Demencia</name>
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        <name>Enfermedad de Alzheimer</name>
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        <name>Enfermedades neuromusculares</name>
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        <name>Ratones 3x-Tg-AD</name>
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                  <text>Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.</text>
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                  <text>Departamento de Documentación y Biblioteca</text>
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                <text>&lt;strong&gt;Components of Ginkgo biloba leaf wax&lt;/strong&gt;</text>
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                <text>1979</text>
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                <text>&lt;strong&gt;Casal, Hector L.&lt;/strong&gt;</text>
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                <text>&lt;a title="curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=1424ef7476f5da983ef6cd034fcf13fe" target="_blank"&gt;&lt;strong&gt;Moyna, Patrick&lt;/strong&gt;&lt;/a&gt;</text>
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                <text>Phytochemistry. v.18, 1979.-- p 1738-1739.</text>
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                <text>Treinta a&amp;ntilde;os de investigaci&amp;oacute;n cient&amp;iacute;fica : 1968-1998 / Patrick Moyna. &amp;nbsp;&lt;br /&gt;&lt;br /&gt;</text>
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                <text>&lt;h3&gt;Derechos&lt;/h3&gt;&#13;
&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Papel (en C&amp;aacute;tedra de Farmacognosia)</text>
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                <text>&lt;strong&gt;Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B&lt;/strong&gt;</text>
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                <text>Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, polydactyly, renal disease and mental retardation. CCDC28B is a BBS-associated protein that we have previously shown plays a role in cilia length regulation whereby its depletion results in shortened cilia both in cells and Danio rerio (zebrafish). At least part of that role is achieved by its interaction with the mTORC2 component SIN1, but the mechanistic details of this interaction and/or additional functions that CCDC28B might play in the context of cilia remain poorly understood. Here we uncover a novel interaction between CCDC28B and the kinesin 1 molecular motor that is relevant to cilia. CCDC28B interacts with kinesin light chain 1 (KLC1) and the heavy chain KIF5B. Notably, depletion of these kinesin 1 components results in abnormally elongated cilia. Furthermore, through genetic interaction studies we demonstrate that kinesin 1 regulates ciliogenesis through CCDC28B. We show that kinesin 1 regulates the subcellular distribution of CCDC28B, unexpectedly, inhibiting its nuclear accumulation, and a ccdc28b mutant missing a nuclear localization motif fails to rescue the phenotype in zebrafish morphant embryos. Therefore, we uncover a previously unknown role of kinesin 1 in cilia length regulation that relies on the BBS related protein CCDC28B.</text>
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                <text>&lt;strong&gt;Lecumberry, Federico&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Irigoin, Florencia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Badano, Jos&amp;eacute; L.&lt;/strong&gt;</text>
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                <text>Scientific Reports v. 8, no. 1, 2018. -- 16p.--e30219</text>
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                <text>Springer Nature Limited</text>
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            <description>Information about rights held in and over the resource</description>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>DOI: 10.1038/s41598-018-21329-6</text>
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                <text>&lt;strong&gt;Activation of the NLRP3 inflamma some by particles from the 1 Echinococcus granulosus laminated layer&lt;/strong&gt;</text>
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                <text>The interaction of dendritic cells and macrophages with a variety of rigid non-cellular&amp;nbsp; particles triggers activation of the NLRP3 inflammasome and consequent secretion of&amp;nbsp; IL-1&amp;beta;. Non-cellular particles can also be generated in the context of helminth infection,&amp;nbsp; as these large pathogens often shed their outermost structures during growth and/or&amp;nbsp; moulting. One such structure is the massive, mucin-based, soft and flexible laminated&amp;nbsp; layer (LL), which protects the larval stages of cestodes of the genus Echinococcus. We&amp;nbsp; show that particles from the E. granulosus LL (pLL) trigger NLRP3- and caspase-1-&amp;nbsp; dependent IL-1&amp;beta; in LPS-primed mouse bone marrow-derived dendritic cells (BMDC).&amp;nbsp; This response can be elicited by pLL particles too large for phagocytosis, and&amp;nbsp; nonetheless requires actin dynamics, Syk and PI3K. These three requirements had&amp;nbsp; already been observed in our previous study on the alteration by pLL of BMDC&amp;nbsp; responses to LPS in terms of CD86, CD40, IL-10 and IL-12: however, we now show&amp;nbsp; that these alterations are independent of NLRP3 and caspase-1. In other words, an initial interaction with particles requiring actin dynamics, Syk and PI3K but not phagocytosis&amp;nbsp; elicits both NLRP3-dependent and NLRP3-independent responses. Intraperitoneal&amp;nbsp; injection of pLL induced IL-1, suggesting that contact with LL materials induces IL- 36 1 in the E. granulosus infection setting. Our results extend NLRP3 inflammasome 37 activation by non-cellular particulate materials both to helminth-derived and to 38 flexible/soft materials. 39 Downloaded from http://iai.asm.org/ on June 24, 2020 by guest</text>
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                <text>&lt;strong&gt;Casaravilla, Cecilia&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;R&amp;uuml;ckerl, Dominik&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Allen, Judith E.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;D&amp;iacute;az, Alvaro&lt;/strong&gt;</text>
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                <text>Infection and Immunity. 2020.-- p. 1-13</text>
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                <text>American Society for Microbiology</text>
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                <text>&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt; (Por favor lea este aviso antes de abrir los documentos u objetos) &lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.</text>
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                <text>&lt;strong&gt;Antitumoral effect of phenazine N5,N10-diioxide derivatives on Caco-2 cells&lt;/strong&gt;</text>
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                <text>We studied the in vitro antitumoral effect of a series of phenazine di-N-oxide derivatives, named 2-chloroacetylamino-7(8)-nitrophenazine N5,N10-dioxide (1), 2-amino-7(8)-(1,3-dioxol-2-yl)phenazine N5,N10-dioxide (2), 2-chloroacetylamino-7(8)-(1,3-dioxol-2-yl)phenazine N5,N10-dioxide (3), and 2-amino-7(8)-methoxyphenazine N5,N10-dioxide (4), on Caco-2 cells. These phenazine N5,N10-dioxide derivatives belong to our in-house chemical library. The products were selected according to their stereoelectronic characteristics and taking into account their differential cytotoxicity against V79 cells. Human colorectal adenocarcinoma cell line Caco-2 was used to study the cell growth inhibition capacity of these compounds, their capacity of altering the cell cycle and possible induction of apoptosis, DNA fragmentation, and genotoxic damage. The IC50 after 24 h of incubation was lower for 1, 2, and 3 (4.8, 46.8, and 8.2 &amp;mu;M, respectively) than for 4 (474.7 &amp;mu;M). Compound 1 induced arrest in the G2/M phase at 24 and 48 h of treatment and apoptosis at the highest doses at 24 h of treatment. These facts were corroborated with caspase 3, caspase 9, and cytochrome c activation and DNA fragmentation at 24 h of treatment. The derivatives studied induced neither significant single strand breaks nor oxidative damage at the different studied times.We concluded that among the series of N5,N10-dioxide phenazine derivatives analyzed, 1, which contains a nitro moiety and a chloroacetamide group, is the most promising as an antitumoral compound.</text>
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                <text>&lt;strong&gt;Pach&amp;oacute;n, O.G.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Azqueta, A.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Lavaggi Destro, Mar&amp;iacute;a Laura&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Lopez de Cerain, Adela&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Creppy, E.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Gonz&amp;aacute;lez, Mercedes&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Centelles, J. J.&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Cascante, Marta&lt;/strong&gt;</text>
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                <text>Chemical Research in Toxicology v. 21, no. 8, 2008. -- p. 1578-1585</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;br /&gt; &lt;br /&gt; (Por favor lea este aviso antes de abrir los documentos u objetos)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;br /&gt; &lt;br /&gt; (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;br /&gt; &lt;br /&gt; &lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Valorization of primary sludge and biosludge from the pulp mill Industry in Uruguay through hydrothermal carbonization&lt;/strong&gt;</text>
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                <text>BIOCOMBUSTIBLES</text>
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                <text>BIBLIOGRAFIA NACIONAL QUIMICA</text>
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                <text>2023</text>
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                <text>Although nowadays landspreading and incineration are the conventional disposal methods for the primary sludge (PS) and biosludge (BS) generated in the wastewater treatment plants of the pulp mill industry in Uruguay, their direct incineration for energy recovery is the most preferable one. Here, we propose the hydrothermal carbonization (HTC) method as a pre treatment to improve the fuel characteristic of PS and BS. Proximate and ultimate analysis, scanning electron microscopy, and thermogravimetric analysis show that the HTC afects PS and BS diferently regarding carbon fxation, energy densifca tion and energy conversion efciency. Moreover, ash composition measured by X-ray fuorescence indicates that the HTC efectively diminishes the slagging and fouling indexes for both feedstocks, which can increase the life expectancy of boil ers. Alternative PS, BS, and their hydrochars were activated with H3PO4 to produce activated carbons, i.g. the BET specifc surface area was as high as 800 m2 /g for PS-AC, and exhibits CO2 adsorption capacity of 5 mmol/g at 10 bar at 273 K. These studies provide alternatives to direct incineration and landspreading of PS and BS in Uruguay to reduce their environmental impact, either by enhancing their fuel quality or by converting them into much more valuable products to face air pollution.</text>
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                <text>&lt;strong&gt;Casco, Mirian Elizabeth&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Moreno, Valent&amp;iacute;n&lt;/strong&gt;</text>
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                <text>&lt;strong&gt;Duarte, Mart&amp;iacute;n&lt;/strong&gt;</text>
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                <text>Waste and Biomass Valorization, 2023.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt;&amp;nbsp;de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt;&amp;nbsp;La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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&lt;p style="margin-bottom: 0cm;"&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;&#13;
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                <text>The volatile components isolated from the root of Angelica (Angelica archangelica L.) cultivated in southern Brazil have been studied. The essential oil was obtained by hydrodistillation; the volatile concentrate was obtained by supercritical fluid extraction (SFE). SFE was conducted at 40&amp;deg;C, 50&amp;deg;C and 60&amp;deg;C, at pressures ranging from 90&amp;ndash;120 bar. The identification of the components was completed using capillary gas chromatography and mass spectrometry based on the retention time on methyl silicone phases. Chemical analysis revealed that although roughly the same compounds were extracted, the two oils had a widely different percentage composition. The supercritical CO2 extraction exhibited a higher number and concentration of oxygenated compounds.&lt;br /&gt;&lt;br /&gt;</text>
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                <text>Journal of Essential Oil Research v. 14, no. 4, 2002. -- p. 282-285</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>This study investigated the microbial community developed in a UASB reactor for hydrogen production and correlated it to reactor performance. The reactor was inoculated with kitchen waste compost and fed with raw cheese whey at two organic loading rates, 20 gCOD/Ld and 30 gCOD/Ld. Hydrogen production was very variable, using an OLR of 30 gCOD/Ld averaged 1.0 LH2/Ld with no methane produced under these conditions. The hydrogen yield was also very variable and far from the theoretical. This low yield could be explained by selection of a mixed fermentative population with presence of hydrogen producing organisms (Clostridium, Ruminococcus and Enterobacter) and other non-hydrogen producing fermenters (Lactobacillus, Dialister and Prevotella). The molecular analysis of the raw cheese whey used for feeding revealed the presence of three predominant organisms that are affiliated with the genera Buttiauxella (a low-yield hydrogen producer) and Streptococcus (a lactic acid-producing fermenter). Although these organisms did not persist in the reactor, the continuous addition of these fermenters could decrease the reactor&amp;rsquo;s hydrogen yield.</text>
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                <text>Water Science and Technology v. 64, no. 11, 2011. -- p. 2265-2273</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
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                <text>In this work, an upflow anaerobic packed bed reactor configuration to produce hydrogen using cheese whey as the substrate was tested. The microbiological composition was linked to the reactor operation.&lt;br /&gt;&lt;br /&gt;Three different organic loading rates of 22, 33, and 37 g COD/L-d were used at a fixed hydraulic retention time of 24 h. The increase of the organic loading rate from the initial value of 22 g COD/L-d to a value of 37 g COD/L-d and the adjustment of the pH to values greater than 5 had a positive effect on the hydrogen production and values of up to 1 L H2/L-d were achieved. The production of hydrogen was stable under all of the investigated conditions, and the problems frequently reported in this kind of reactors (bed clogging, methanogenesis and solvent production) were not observed during operation.&lt;br /&gt;&lt;br /&gt;The highest hydrogen yield was 1.1 mol H2/mol lactose far from the maximum theoretical value (8 mol H2/mol lactose), but similar to previous works using cheese whey as substrate. The microbiological analysis showed a mixed population with a low proportion of hydrogen-producing fermenters (Clostridium and Klebsiella) and other non-hydrogen-producing organisms.&lt;br /&gt;&lt;br /&gt;</text>
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&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya&lt;/strong&gt; protege el derecho de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes&lt;/p&gt;&#13;
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA&lt;/strong&gt; - La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Preparation and crystal structure of new samarium complexes with glutamic acid&lt;/strong&gt;</text>
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                <text>Samarium complexes with glutamic acid containing cationic [Sm2(Glu)2(H2O)8]4&amp;thorn; units have been prepared and characterized by using elemental analysis, infrared absorption spectra and thermal analysis. In addition, the crystal and molecular structure of [Sm2(Glu)2(H2O)8](ClO4)4&amp;middot;3H2O was determined by X-ray diffraction. The presence of glutamic acid in the Sm coordination sphere allows the formation of a singular extended 2D arrangement. Sm atoms are nine coordinated, in a monocapped square antiprism geometry. They are connected by means of different m-COO2 bridges, involving a- and gcarboxylate groups of the amino acid.</text>
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                <text>&lt;strong&gt;Dominguez, S.&lt;/strong&gt;</text>
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                <text>Journal of Molecular Structure v. 660, no. 1-3, 2003. -- p. 99-106</text>
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&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt; La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>Ingl&amp;eacute;s</text>
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                <text>&lt;strong&gt;Castiglioni, M.&lt;/strong&gt;</text>
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                <text>Veterinaria (Montevideo),. v.71, 1979.-- p 133-135.</text>
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                <text>&lt;h3&gt;Derechos&lt;/h3&gt;&#13;
&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho de autor&lt;/strong&gt; sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;Evaluation of the chemical composition of the essential oil from a Brazilian Poejo, Hesperozygis myrtoides (St. Hill ex Benth.) Epling at different collection periods and sites&lt;/strong&gt;</text>
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                <text>ACEITES ESENCIALES</text>
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                <text>COMPOSICION QUIMICA</text>
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                <text>Hesperozygis myrtoides is a native species from Cerrado and Atlantic Forest of Brazil. The essential oil from aerial parts of this plant, collected at different periods of the year, was obtained by hydrodistillation and analyzed by GC and CG-MS. The most abundant compounds were limonene (2.1&amp;ndash;22.7%), isomenthone (14.3&amp;ndash;47.7%), neo-isomenthol (1.8&amp;ndash;4.4%), pulegone (19.8&amp;ndash;57.3%) and isomenthyl acetate (0.3&amp;ndash;14.3%). The chromatographic data were processed using hierarchical cluster analysis (HCA) and principal component analysis (PCA) based on the major compounds. The multivariate analyses (MVA) indicated that the variation of chemical composition of principal substances of H. myrtoides essential oil depends on the altitude. The enantiomeric distribution of (R)-(+)-pulegone and (+)-isomenthone were established for the first time for this essential oil by bidimensional GC-chiral analysis.</text>
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                <text>&lt;strong&gt;Evaluation of the chemical composition of the essential oil from a Brazilian Poejo, Hesperozygis myrtoides (St. Hill ex Benth.) Epling at different collection periods and sites&lt;/strong&gt;</text>
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                <text>Hesperozygis myrtoides is a native species from Cerrado and Atlantic Forest of Brazil. The essential oil from aerial parts of this plant, collected at different periods of the year, was obtained by hydrodistillation and analyzed by GC and CG-MS. The most abundant compounds were limonene (2.1&amp;ndash;22.7%), isomenthone (14.3&amp;ndash;47.7%), neo-isomenthol (1.8&amp;ndash;4.4%), pulegone (19.8&amp;ndash;57.3%) and isomenthyl acetate (0.3&amp;ndash;14.3%). The chromatographic data were processed using hierarchical cluster analysis (HCA) and principal component analysis (PCA) based on the major compounds. The multivariate analyses (MVA) indicated that the variation of chemical composition of principal substances of H. myrtoides essential oil depends on the altitude. The enantiomeric distribution of (R)-(+)-pulegone and (+)-isomenthone were established for the first time for this essential oil by bidimensional GC-chiral analysis.</text>
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                <text>Journal of Essential Oil Research v. 28, no. 4, 2016. -- p. 312-321</text>
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&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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                <text>&lt;strong&gt;A novel thermophilic and halophilic esterase from Janibacter sp. R02,the first member of a new lipase family (Family XVII)&lt;/strong&gt;</text>
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                <text>Janibacter sp. strain R02 (BNM 560) was isolated in our laboratory from an Antarctic soil sample. A remarkable trait of the strain was its high lipolytic activity, detected in Rhodamine-olive oil supplemented plates. Supernatants of Janibacter sp. R02 displayed superb activity on transesterification of acyl glycerols, thus being a good candidate for lipase prospection. Considering the lack of information concerning lipases of the genus Janibacter, we focused on the identification, cloning, expression and characterization of the extracellular lipases of this strain. By means of sequence alignment and clustering of consensus nucleotide sequences, a DNA fragment of 1272 bp was amplified, cloned and expressed in E. coli. The resulting recombinant enzyme, named LipJ2, showed preference for short to medium chain-length substrates, and displayed maximum activity at 80 &amp;deg;C and pH 8&amp;ndash;9, being strongly activated by a mixture of Na+ and K+. The enzyme presented an outstanding stability regarding both pH and temperature. Bioinformatics analysis of the amino acid sequence of LipJ2 revealed the presence of a consensus catalytic triad and a canonical pentapeptide. However, two additional rare motifs were found in LipJ2: an SXXL &amp;beta;-lactamase motif and two putative Y-type oxyanion holes (YAP). Although some of the previous features could allow assigning LipJ2 to the bacterial lipase families VIII or X, the phylogenetic analysis showed that LipJ2 clusters apart from other members of known lipase families, indicating that the newly isolated Janibacter esterase LipJ2 would be the first characterized member of a new family of bacterial lipases.</text>
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                <text>&lt;p&gt;&lt;strong&gt;Informaci&amp;oacute;n sobre Derechos de Autor&lt;/strong&gt;&lt;/p&gt;&#13;
&lt;p&gt;(Por favor lea este aviso antes de abrir los documentos u objetos)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;La legislaci&amp;oacute;n uruguaya protege el derecho&lt;/strong&gt; de autor sobre toda creaci&amp;oacute;n literaria, cient&amp;iacute;fica o art&amp;iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&amp;oacute;n a lo establecido por el derecho com&amp;uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006)&lt;/p&gt;&#13;
&lt;p&gt;&lt;strong&gt;ADVERTENCIA -&lt;/strong&gt; La consulta de este documento queda condicionada a la aceptaci&amp;oacute;n de las siguientes condiciones de uso: Este documento es &amp;uacute;nicamente para usos privados enmarcados en actividades de investigaci&amp;oacute;n y docencia. No se autoriza su reproducci&amp;oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&amp;oacute;n o cita de partes debe indicarse el nombre de la persona autora.&lt;/p&gt;</text>
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