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https://riquim.fq.edu.uy/files/original/2b52e58a72dcf0f2202e169f5e1e96ff.pdf
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https://riquim.fq.edu.uy/files/original/9c805263524ac1f86b5813db5db75359.jpg
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8
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3
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194
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148
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Title
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Bibliografía Nacional Química
Description
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Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
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Departamento de Documentación y Biblioteca
RIQUIM
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PDF
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Title
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<strong>Conformational analysis of the natural iron chelator myo-inositol 1,2,3-trisphosphate using a pyrene-based fluorescent mimic.</strong>
Subject
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<p>ANTIOXIODANTES</p>
HIERRO NATURAL
CATIONES METÁLICOS
TERMODINÁMICA
CALCIO
ALCOHOLES
ANÁLISIS CONFORMACIONAL
BIBLIOGRAFIA NACIONAL QUIMICA
2010
Abstract
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myo-Inositol phosphates possessing the 1,2,3-trisphosphate motif share the remarkable ability to completely inhibit iron-catalysed hydroxyl radical formation. The simplest derivative, myo-inositol 1,2,3-trisphosphate [Ins(1,2,3)P3], has been proposed as an intracellular iron chelator involved in iron transport. The binding conformation of Ins(1,2,3)P3 is considered to be important to complex Fe3+ in a ‘safe’ manner. Here, a pyrene-based fluorescent probe, 4,6-bispyrenoyl-myo-inositol 1,2,3,5-tetrakisphosphate [4,6-bispyrenoyl Ins(1,2,3,5)P4], has been synthesised and used to monitor the conformation of the 1,2,3-trisphosphate motif using excimer fluorescence emission. Ring-flip of the cyclohexane chair to the penta-axial conformation occurs upon association with Fe3+, evident from excimer fluorescence induced by p–p stacking of the pyrene reporter groups, accompanied by excimer formation by excitation at 351 nm. This effect is unique amongst biologically relevant metal cations, except for Ca2+ cations exceeding a 1 : 1 molar ratio. In addition, the thermodynamic constants for the interaction of the fluorescent probe with Fe3+ have been determined. The complexes formed between Fe3+ and 4,6-bispyrenoyl Ins(1,2,3,5)P4 display similar stability to those formed with Ins(1,2,3)P3, indicating that the fluorescent probe acts as a good model for the 1,2,3-trisphosphate motif. This is further supported by the antioxidant properties of 4,6-bispyrenoyl Ins(1,2,3,5)P4, which closely resemble those obtained for Ins(1,2,3)P3. The data presented confirms that Fe3+ binds tightly to the unstable penta-axial conformation of myo-inositol phosphates possessing the 1,2,3-trisphosphate motif.
Creator
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<strong>Mansell, David</strong>
<strong>Rattray, N.</strong>
<strong>Etchells, L. L.</strong>
<strong>Schwalbe, C. H.</strong>
<strong>Blake, A. J.</strong>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=b1b8a8c8b1a5835b874ac1994003c38d"><strong>Torres, Julia</strong></a>
<a title="Curriculum" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=6f16399c452f7b13f8a01a148cb38e12"><strong>Kremer, Carlos</strong></a>
<strong>Bichenkova, E. V.</strong>
<strong>Barker, C. J.</strong>
<strong>Freeman, S.</strong>
Source
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Organic and Biomolecular Chemistry v. 8, no. 12, 2010. -- p. 2850-2858
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The Royal Society of Chemistry
Date
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2010
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PDF
Language
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Inglés
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Artículo
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DOI: 10.1039/c001078b
Alcoholes
Análisis conformacional
Antioxidantes
Calcio
Cationes metálicos
Hierro natural
Termodinámica