1
25
2
-
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
155
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Potential contribution of PEP carboxykinase dependent malate dismutation to the hypoxia response in C. elegans</strong>
Subject
The topic of the resource
C. ELEGANS
NEMATODA
BIBLIOGRAFIA NACIONAL QUIMICA
2023
Creator
An entity primarily responsible for making the resource
<strong>Comas Ghierra, Rosina</strong>
<strong>Romanelli Cedrez, Laura</strong>
<strong>Salinas, Gustavo</strong>
Source
A related resource from which the described resource is derived
Nature Communications, v.14, n°1, 2023. -- e3938
Publisher
An entity responsible for making the resource available
Springer
Date
A point or period of time associated with an event in the lifecycle of the resource
2023
Rights
Information about rights held in and over the resource
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
Format
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PDF
Extent
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3 p.
Language
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Inglés
Type
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Artículo
Identifier
An unambiguous reference to the resource within a given context
10.1038/s41467-023-39510-5
C. Elegans
Nematoda
-
https://riquim.fq.edu.uy/files/original/f4255e636d68b2ecfb5a1d7012472f25.pdf
abd5965cc4a32cfd8ffe6577786811ea
https://riquim.fq.edu.uy/files/original/d3219a473db4e66ce486f1554192fed8.jpg
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Omeka Image File
The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files.
Bit Depth
8
Channels
3
Height
155
Width
156
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bibliografía Nacional Química
Description
An account of the resource
Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
An entity responsible for making contributions to the resource
Departamento de Documentación y Biblioteca
RIQUIM
Document
A resource containing textual data. Note that facsimiles or images of texts are still of the genre text.
Original Format
If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data
PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
<strong>Structure-based boisosterism design, synthesis, biological evaluation and in silico studies of benzamide analogs as potential anthelmintics</strong>
Subject
The topic of the resource
BIOISOSTERISMO
<a><span id="normalb" class="text3">NEMATODA</span></a>
C. ELEGANS
ECHINOCOCCUS GRANULOSUS
BIBLIOGRAFIA NACIONAL QUIMICA
2022
Abstract
A summary of the resource.
A recent screen of 67,012 compounds identified a new family of compounds with excellent nematicidal activity: the ortho-substituted benzamide families Wact-11 and Wact-12. These com pounds are active against Caenorhabditis elegans and parasitic nematodes by selectively inhibiting nematode complex II, and they display low toxicity in mammalian cells and vertebrate organisms. Although a big number of benzamides were tested against C. elegans in high-throughput screens, bioisosteres of the amide moiety were not represented in the chemical space examined. We thus iden tified an opportunity for the design, synthesis and evaluation of novel compounds, using bioisosteric replacements of the amide group present in benzamides. The compound Wact-11 was used as the reference scaffold to prepare a set of bioisosteres to be evaluated against C. elegans. Eight types of amide replacement were selected, including ester, thioamide, selenoamide, sulfonamide, alkyl thio and oxo-amides, urea and triazole. The results allowed us to perform a structure–activity relationship, highlighting the relevance of the amide group for nematicide activity. Experimental evidence was complemented with in silico structural studies over a C. elegans complex II model as a molecular target of benzamides. Importantly, compound Wact-11 was active against the flatworm Echinococcus granulosus, suggesting a previously unreported pan-anthelmintic potential for benzamides.
Creator
An entity primarily responsible for making the resource
<a href="https://exportcvuy.anii.org.uy/cv/?09f6723c0eabc2c919960c552c5adf85" target="_blank"><strong>Vairoletti , Franco</strong></a>
<a href="https://exportcvuy.anii.org.uy/cv/?8e4377ca77382678fd5af0d455590aa18a44e65bac89340cfafbbd41152343acd96dc3153f75f2fdf08a92578f213300543d33a6754527876021976e495c507b" target="_blank"><strong>Paulino, Margot</strong></a>
<a href="https://exportcvuy.anii.org.uy/cv/?11f116dbdcd0917430c764781820c3ae07133f652f4972256dc46f54fda1a3fcf8ce8ef0955ba2079acd7eb19d1ee52d88035eacfdec3666f5e20b2b35381b70" target="_blank"><strong>Mahler, Graciela</strong></a>
<a href="https://exportcvuy.anii.org.uy/cv/?972518dae04cc6f1d53fd01909f7c2f4952184c3eedf364530afd35a4c507484cce1f86606ac8d829a37e89b7a9f837b6b0632e94efbaf9ba6abf23efe48f1dc" target="_blank"><strong>Salinas, Gustavo</strong></a>
<a href="https://exportcvuy.anii.org.uy/cv/?7f698a1299f8613291da7800fd8927d1c3c8f7d6c4825f88511ab29a883aec94cfcc68b226e6ac4cfd2242415a01b6e3f1aff18fab1609921754135148cd1415" target="_blank"><strong>Saiz, Cecilia</strong></a>
Source
A related resource from which the described resource is derived
Molecules v.27, n° 9, 2022.-- e2659
Publisher
An entity responsible for making the resource available
MDPI
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Rights
Information about rights held in and over the resource
<p><span><strong>Información sobre Derechos de Autor</strong></span></p>
<p><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p><strong>La legislación uruguaya protege el derecho de autor</strong><span> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<p><strong>ADVERTENCIA:</strong><span> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</span></p>
Format
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PDF
Language
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Inglés
Type
The nature or genre of the resource
Artículo
Identifier
An unambiguous reference to the resource within a given context
10.3390/molecules27092659
Bioisosterismo
C. Elegans
Echinoccocus granulosus
Nematoda