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<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6232">
    <dcterms:title><![CDATA[<strong>The lymphocytic scavenger receptor CD5 shows therapeutic potential in mouse models of fungal infection</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[HONGOS
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    <dcterms:subject><![CDATA[INFECCION
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    <dcterms:subject><![CDATA[INMUNOTERAPIA
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    <dcterms:subject><![CDATA[CANDIDA ALBICANS
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    <dcterms:subject><![CDATA[FLUCONAZOL
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    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA
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    <dcterms:subject><![CDATA[2020
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    <dcterms:subject><![CDATA[CRYPTOCOCCUS NEOFORMANS
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    <dcterms:abstract><![CDATA[Background: Invasive fungal diseases represent an unmet clinical need that could 29 benefit from novel immunotherapeutic approaches. Host pattern-recognition receptors 30 (e.g., Toll-like receptors, C-type lectins or Scavenger receptors) that sense conserved 31 fungal cell wall constituents may provide suitable immunotherapeutic antifungal agents. 32 Thus, we explored the therapeutic potential of the lymphocyte class I scavenger receptor 33 CD5, a non-redundant component of the antifungal host immune response that binds to 34 fungal &beta;-glucans. 35 Methods: antifungal properties of the soluble ectodomain of human CD5 (shCD5) were 36 assessed in vivo in experimental models of systemic fungal infection induced by 37 pathogenic species (Candida albicans and Cryptococcus neoformans). In vitro 38 mechanistic studies were performed by means of fungal-spleen cell co-cultures. 39 Results: shCD5-induced survival of lethally infected mice was dose and time-dependent 40 and concomitant with reduced fungal load and increased leukocyte infiltration in 41 primary target organ. Additive effects were observed in vivo after shCD5 was combined 42 with sub-optimal doses of fluconazole. Ex vivo addition of shCD5 to fungal-spleen cell 43 co-cultures increased release of pro-inflammatory cytokines involved in antifungal 44 defence (TNF-&alpha; and IFN-&gamma;) and reduced the number of viable C. albicans. 45 Conclusions: The results prompt further exploration of the adjunctive therapeutic 46 potential of shCD5 in severe invasive fungal diseases.
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    <dcterms:creator><![CDATA[<strong>Velasco de Andr&eacute;s, Mar&iacute;a</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Catal&agrave;, Cristina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Casad&oacute;-Llombart, Sergi</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mart&iacute;nez-Florensa, Mario</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sim&otilde;es, In&ecirc;s</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Garc&iacute;a-Luna, Joaqu&iacute;n</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Mourglia-Ettlin , Gustavo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Zaragoza, Oscar</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carreras, Esther</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Lozano, Francisco</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Antimicrobial agents and chemotherapy, v. 65 , no, 1, 2020.--p. 1-34.
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    <dcterms:publisher><![CDATA[American Society for Microbiology
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    <dcterms:date><![CDATA[2020
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    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong> (Por favor lea este aviso antes de abrir los documentos u objetos)<strong> La legislaci&oacute;n uruguaya protege el derecho de autor </strong>sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>
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    <dcterms:format><![CDATA[Pdf
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    <dcterms:language><![CDATA[Ingl&eacute;s
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    <dcterms:type><![CDATA[Art&iacute;culo
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    <dcterms:identifier><![CDATA[doi:10.1128/AAC.01103-20
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</rdf:Description></rdf:RDF>
