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https://riquim.fq.edu.uy/files/original/92048f8ea4b40597d92c0e41a1966902.pdf
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https://riquim.fq.edu.uy/files/original/227cf7dbf340e8e418400b37c831131e.jpg
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Omeka Image File
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Bit Depth
8
Channels
3
Height
168
Width
155
Dublin Core
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Title
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Bibliografía Nacional Química
Description
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Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
Document
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Original Format
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Pdf
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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<strong>Electrochemical, mechanistic, and DFT studies of amines derived diphosphines containing Ru(II)-cymene complexes with potent in vitro cytotoxic activity against HeLa and the triple-negative breast cancer cells MDA-MB-231</strong>
Subject
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ELECTROQUIMICA
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RUTENIO-COMPLEJOS
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CANCER DE MAMA
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DIFOSFINAS
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BIBLIOGRAFIA NACIONAL QUIMICA
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2020
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Abstract
A summary of the resource.
Complexes with general formula [RuCl(η6-p-cymene)(P-NR-P)]X (R = CH2Py (Py = pyridine)-[1a]+, CH2Ph (Ph = phenyl)-[1b]+, Ph-[1c] and p-tol (p-tol = p-tolyl)-[1d]+; X = PF6- or BF4-) were evaluated as cytotoxic agents against two cancer cell lines (HeLa and MDA-MB-231). All metal complexes are active in the range of concentrations tested (up to 100 μmol L-1). The IC50 (μmol L-1) values for the metal complexes are lower than that found for cisplatin. The activities are up to 6- and 15-fold higher than cisplatin for HeLa and MDA-MB-231 cancer cell lines, respectively. Studies of DNA binding and DNA cleavage were performed. DNA binding studies revealed a modest hypochromic shift in the metal complexes electronic spectra, indicating a weak interaction with Kb values in the range of 1.7 × 103-1.6 × 104. Although the cleavage tests revealed that in the dark DNA is not a biological target for these metal complexes, upon blue light irradiation they are activated causing DNA cleavage. Electrochemical studies showed the presence of two independent redox processes, one attributed to the oxidation process of Ru2+ → Ru3+ (EC process) and the other one to the reduction of Ru2+ → Ru1+, which is further reduced to Ru0 (ECE mechanism). In both processes, coupled chemical reactions were observed. DFT calculations were performed to support the electrochemical/chemical behavior of the complexes. The reactivity of complex [1b]BF4 with CH3CN was evaluated and two complexes were isolated [2b]BF4 and [3b]BF4. The complex mer-[RuCl(CH3CN)3(P-NCH2Ph-P)]BF4 ([2b]BF4) was isolated after refluxing the precursor [1b]BF4 in CH3CN. Isomerization of [2b]BF4 in CH3CN resulted in the formation of fac-[RuCl(CH3CN)3(P-NCH2Ph-P)]BF4. An attempt to isolate the fac-isomer by adding diethyl ether was unsuccessful, and the complex [3b]BF4 was observed as the major component. The complex [Ru2(μ-Cl3)(CH3CN)2(P-NCH2Ph-P)2]BF4 ([3b]BF4) proved to be very stable and can be obtained from both the mer- and the fac-isomers. The molecular structures of [1b]BF4 and [3b]BF4 were solved by single-crystal X-ray diffraction.
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Creator
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<strong>Da Silva, Juliana P.</strong>
<strong>Fuganti, Otávio</strong>
<strong>Kramer, M. Gabriela</strong>
<strong>Facchin, Gianella</strong>
<strong>Aquino, Luca E. N.</strong>
<strong>Ellena, Javier</strong>
<strong>Back, David F.</strong>
<strong>Gondim, Ana C. S.</strong>
<strong>Souza, Eduardo H. S.</strong>
<strong>Lopes, Luiz G. F.</strong>
<strong>Machado, Silvane</strong>
<strong>Guimarães, I. D. L.</strong>
<strong>Wohnrath, Karen</strong>
<strong>De Araújo, Márcio P.</strong>
Source
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Dalton Transactions v. 49, no. 47, 2020. -- p. 16498-16514
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Publisher
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Royal Society of Chemistry
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Date
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2020
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Rights
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<p><strong>Información sobre Derechos de Autor</strong> (Por favor lea este aviso antes de abrir los documentos u objetos)<strong> La legislación uruguaya protege el derecho de autor </strong>sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
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Format
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Pdf
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Language
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Inglés
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Type
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Artículo
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Identifier
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Doi:10.1039/d0dt02500c
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Cáncer de mama
Difosfinas
Electroquímica
Rutenio-complejos