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https://riquim.fq.edu.uy/files/original/f32e93cd73954bc9a350abb1d734ab59.doc
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https://riquim.fq.edu.uy/files/original/bb3060b01ab767586b1c43213547c755.jpg
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Omeka Image File
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8
Channels
3
Height
131
Width
101
Dublin Core
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Title
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Bibliografía Nacional Química
Description
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Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
Document
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Original Format
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PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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<strong>Tissue transglutaminase on trophoblast cells as a possible target of autoantibodies contributing to pregnancy complications in celiac patients</strong>
Subject
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ENZIMAS
ENFERMEDAD CELIACA
EMBARAZO-COMPLICACIONES
TRANSGLUTAMINASAS
BIBLIOGRAFIA NACIONAL QUIMICA
2014
Abstract
A summary of the resource.
<div id="aji12290-sec-0001" class="section">
<h4>Problem</h4>
<div class="para">
<p>Women with celiac disease (CD) are often affected by atypical presentations of the disease associated with reproductive disorders as a main extra-digestive complaint. Here, we analyzed if autoantibodies against tissue transglutaminase (tTG) in sera from CD patients with reproductive disorders could display direct effects through their interaction with tTG expressed on trophoblast cells and phagocytes inducing tissue damage and interfering in the clearance of trophoblast apoptotic bodies.</p>
</div>
</div>
<div id="aji12290-sec-0002" class="section">
<h4>Method of study</h4>
<div class="para">
<p>Sera from CD women with reproductive disorders were obtained, and their ability to induce apoptosis of Swan-71 (cytotrophoblast cell line) and to modulate the wound-healing and phagocytes process was tested.</p>
</div>
</div>
<div id="aji12290-sec-0003" class="section">
<h4>Results</h4>
<div class="para">
<p>Swan-71 cells expressed tTG and CD sera displayed a significant decrease in trophoblast cell migration and a delay in injury healing on trophoblast cells, compared with those observed with control sera. Moreover, CD sera significantly reduced trophoblast cell proliferation and increased apoptosis levels in comparison with those observed in the control sera. Finally, autoantibodies against tTG interfere in the clearance of trophoblast apoptotic bodies through a mechanism involving MFG-E8 (milk fat globulin-EGF factor 8)–tTG binding.</p>
</div>
</div>
<div id="aji12290-sec-0004" class="section">
<h4>Conclusion</h4>
<div class="para">
<p>The anti-tTG antibodies might contribute to trophoblast damage and disrupt the phagocytosis process of apoptotic bodies that could promote a pro-inflammatory microenvironment.</p>
</div>
</div>
Creator
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<strong>Sóñora Muniz, Cecilia Beatriz</strong>
<strong>Calo, Guillermina</strong>
<strong>Fraccaroli, Laura</strong>
<strong>Pérez-Leirós, Claudia</strong>
<strong>Hernández, Ana</strong>
<strong>Ramhorst, Rosanna</strong>
Source
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American Journal of Reproductive Immunology v. 72, no. 5, 2014. -- p. 485-495
Publisher
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Wiley-Blackwell
Date
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2014
Rights
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<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya</strong> protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
<p> </p>
<p> </p>
Format
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PDF
Language
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Inglés
Type
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Artículo
Identifier
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DOI: 10.1111/aji.12290
Embarazo-Complicaciones
Enfermedad celíaca
Enzimas
Transglutaminasas