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https://riquim.fq.edu.uy/files/original/99b381bcac0ed318b9ecd4b202235b91.pdf
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https://riquim.fq.edu.uy/files/original/f0b3bb9eaddabf1218d4df3316c48792.jpg
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Omeka Image File
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Bit Depth
8
Channels
3
Height
155
Width
117
Dublin Core
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Title
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Bibliografía Nacional Química
Description
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Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
Contributor
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Departamento de Documentación y Biblioteca
RIQUIM
Document
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Original Format
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PDF
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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<strong>Polyreactive antibodies as potential humoral biomarkers of host resistance to cystic echinococcosis</strong>
Subject
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BIOMARCADORES
EQUINOCOCOSIS
HIDATIDOSIS
ECHINOCOCCUS GRANULOSUS
ANTICUERPOS
BIBLIOGRAFIA NACIONAL QUIMICA
2021
Abstract
A summary of the resource.
<p>Polyreactive antibodies (pAb) bind to a broad range of unrelated structures, providing hosts with functional components able to rapidly recognize and protect against different pathogens. However, their roles against helminth parasites are still unexplored. Here, pAb profiles were analysed in cystic echinococcosis (CE), a zoonosis caused by the cestode Echinococcus granulosus sensu lato. Levels of anti-DNP (2,4-dinitrophenyl-hapten) antibodies were measured as a surrogate parameter of pAb in different biological settings. Firstly, levels of serum and peritoneal pAb were measured during early experimental secondary CE, using both high (Balb/c) and low (C57Bl/6) susceptible mouse strains. Serum pAb mostly differed in normal mice, being pAb levels of IgG subclasses with poor anti-parasite activities predominant in Balb/c animals.<br />Conversely, peritoneal pAb isotypes/subclasses with efficient anti-parasite activities predominated in normal and infected C57Bl/6 mice. Secondly, sera from potentially resistant patients, susceptible individuals and healthy donors were analysed, showing higher pAb levels of the IgA and IgG—particularly IgG1—isotypes in potentially resistant individuals compared to control groups. Finally, since remarkable differences were observed in pAb profiles according to the intrinsic host susceptibility to the infection, we proposed here that pAb might be considered as potential humoral biomarkers<br />for host resistance to CE.</p>
Creator
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<strong>García Luna, Joaquín</strong>
<strong>Magnone, Javier</strong>
<strong>Miles, Sebastián</strong>
<strong>López Santurio, Camila</strong>
<strong>Dematteis, Sylvia</strong>
<strong>Mourglia Ettlin, Gustavo</strong>
Source
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Parasite Immunology v. 43, n°3, 2021. -- pp. 1-6. -- e12802
Publisher
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Wiley
Date
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2021
Rights
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<p dir="ltr"><strong>Información sobre Derechos de Autor</strong></p>
<p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p dir="ltr"><strong>La legislación uruguaya protege el derechode autor</strong><span> sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong><span> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</span></span>
Format
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PDF
Language
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Inglés
Type
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Artículo
Identifier
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<span id="docs-internal-guid-f6781b37-7fff-23b6-f29f-7d2d19c9cc81"><span>10.1111/pim.12802 </span></span>
Anticuerpos
Biomarcadores
Echinoccocus granulosus
Equinococosis
Hidatosis