<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2550">
    <dcterms:title><![CDATA[<strong>Mucosal vaccination delays or prevents prion infection via an oral route.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[INMUNOGLOBULINA A]]></dcterms:subject>
    <dcterms:subject><![CDATA[VACUNAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[SALMONELLAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2005]]></dcterms:subject>
    <dcterms:abstract><![CDATA[In recent years major outbreaks of prion disease linked to oral exposure of the prion agent have occurred in animal and human populations. These disorders are associated with a conformational change of a normal protein, PrPC (prion protein cellular), to a toxic and infectious form, PrPSc (prion protein scrapie). None of the prionoses currently have an effective treatment. A limited number of active immunization approaches have been shown to slightly prolong the incubation period of prion infection. Active immunization in wild-type animals is hampered by auto-tolerance to PrP and potential toxicity. Here we report that mucosal vaccination with an attenuated Salmonella vaccine strain expressing the mouse PrP, is effective at overcoming tolerance to PrP and leads to a significant delay or prevention of prion disease in mice later exposed orally to the 139A scrapie strain. This mucosal vaccine induced gut anti-PrP immunoglobulin (Ig)A and systemic anti-PrP IgG. No toxicity was evident with this vaccination approach. This promising finding suggests that mucosal vaccination may be a useful method for overcoming tolerance to PrP and preventing prion infection among animal and potentially human populations at risk.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Go&ntilde;i, Fernando</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Knudsen, E</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Schreiber, F</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Scholtzova, H</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Pankiewicz, J</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carp, R</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Meeker, H. C</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Rubenstein, R</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Brown, D. R.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sy, M. S.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Chabalgoity, Alejandro</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Sigurdsson, E. M</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Wisniewski, T</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Neuroscience v. 133, no. 2, 2005. -- p. 413-421]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[2005]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[doi:10.1016/j.neuroscience.2005.02.031]]></dcterms:identifier>
</rdf:Description></rdf:RDF>
