<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6482">
    <dcterms:title><![CDATA[<strong>T908 Polymeric Micelles Improved the Uptake of Sgc8-c Aptamer Probe in Tumor-Bearing Mice: A Co-Association Study between the Probe and Preformed Nanostructures</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[<p>MICELAS POLIMERICAS</p>]]></dcterms:subject>
    <dcterms:subject><![CDATA[<p>APTAMERO SGC8-C</p>]]></dcterms:subject>
    <dcterms:subject><![CDATA[<p>ORIENTACION ACTIVA</p>]]></dcterms:subject>
    <dcterms:subject><![CDATA[<p>SONDAS</p>]]></dcterms:subject>
    <dcterms:subject><![CDATA[<p>TUMOR</p>]]></dcterms:subject>
    <dcterms:subject><![CDATA[<p>BIBLIOGRAFIA NACIONAL QUIMICA</p>]]></dcterms:subject>
    <dcterms:subject><![CDATA[<p>2022</p>]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Aptamers are oligonucleotides that have the characteristic of recognizing a target with high affinity and specificity. Based on our previous studies, the aptamer probe Sgc8-c-Alexa647 is a promising tool for molecular imaging of PTK7, which is an interesting biomarker in cancer. In order to improve the delivery of this probe as well as create a novel drug delivery nanosystem targeted to the PTK7 receptor, we evaluate the co-association between the probe and preformed nanostructures. In this work, preformed pegylated liposomes (PPL) and linear and branched pristine polymeric micelles (PMs), based on PEO&ndash;PPO&ndash;PEO triblock copolymers were used: poloxamer F127&reg; and poloxamines T1307&reg; and T908&reg;. For it, Sgc8-c-Alexa647 and its co-association with the different nanostructures was exhaustively analyzed. DLS analysis showed nanometric sizes, and TEM and AFM showed notable differences between free- and co-associated probe. Likewise, all nanosystems were evaluated on A20 lymphoma cell line overexpressing PTK7, and the confocal microscopy images showed distinctness in cellular uptake. Finally, the biodistribution in BALB/c mice bearing lymphoma-tumor and pharmacokinetic study revealed an encouraging profile for T908-probe. All data obtained from this work suggested that PMs and, more specifically T908 ones, are good candidates to improve the pharmacokinetics and the tumor uptake of aptamer-based probes.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Castelli, Romina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ibarra, Manuel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Faccio,&nbsp;Ricardo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Miraballes,&nbsp;Iris</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fern&aacute;ndez,&nbsp;Marcelo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Moglioni,&nbsp;Albertina</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cabral,&nbsp;Pablo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Cerecetto,&nbsp;Hugo</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Glisoni,&nbsp;Romina J.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Calzada,&nbsp;Victoria</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Pharmaceuticals, v.15, n&deg;15, 2022. --]]></dcterms:source>
    <dcterms:publisher><![CDATA[MDPI]]></dcterms:publisher>
    <dcterms:date><![CDATA[2022]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr">(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derecho de autor</strong>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[10.3390/ph15010015]]></dcterms:identifier>
</rdf:Description></rdf:RDF>
