1 25 1 https://riquim.fq.edu.uy/files/original/684d887b69ab6425b46ec761e08e0032.pdf f4be5d6a55128546ea446f4cac4f93a1 https://riquim.fq.edu.uy/files/original/b2d675667d8bbe190b7a9a2a9aaf11f2.gif 5bb9f24586fbda57b7cab55b44f5530e Omeka Image File The metadata element set that was included in the `files_images` table in previous versions of Omeka. These elements are common to all image files. Bit Depth 8 Channels 3 Height 175 Width 134 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bibliografía Nacional Química Description An account of the resource Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha. Contributor An entity responsible for making contributions to the resource Departamento de Documentación y Biblioteca RIQUIM Document A resource containing textual data. Note that facsimiles or images of texts are still of the genre text. Original Format If the image is of an object, state the type of object, such as painting, sculpture, paper, photo, and additional data PDF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource <strong>Linear and extended : a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10</strong> Subject The topic of the resource PEPTIDOS GLUTAMINA POLIGLUTAMINA ANTICUERPOS BIBLIOGRAFIA NACIONAL QUIMICA 2013 Abstract A summary of the resource. A long-standing pathomechanistic model proposes that the polyglutamine (polyQ)-length-dependent toxicity threshold observed in all polyQ diseases is triggered by a conformational change within the monomer that occurs only above a certain polyQ length. If true, this yet undefined and elusive mutant-specific toxic conformation would constitute a direct therapeutic target. Three anti-polyQ antibodies&mdash;MW1, 1C2 and 3B5H10&mdash;have been extensively used to probe the conformation of polyQ. The crystal structure of the MW1 epitope reveals a linear, non-pathogenic polyQ. In contrast, although the detailed structure of its epitope is unknown, the 3B5H10 antibody is widely advertised and used as a conformational antibody that recognizes the toxic conformation of expanded polyQ. We solved the crystal structure of the 1C2 antigen-binding domain (1C2-Fab) and performed a direct comparison between the 1C2, MW1 and 3B5H10 structures. The MW1 and 1C2 antibodies have similar sequences and structures, consistent with their binding to short polyQ and their polyQ length-discrimination properties. Unexpectedly, the 3B5H10 antibody also shares striking features with MW1 and 1C2, which prompted us to revisit its binding properties. We show that the 3B5H10 epitope is actually a short, non-pathogenic polyQ. All three antibodies MW1, 1C2 and 3B5H10 interact similarly with polyQ of various lengths, and bind small polyQ epitopes in similar linear and extended conformations. Together with studies published during the recent years, our work argues against the hypothesis that a mutant-specific conformation in monomeric polyQ molecules is the toxic entity responsible for polyQ diseases.<br /><br /> Creator An entity primarily responsible for making the resource <strong>Klein Fabrice, A. C.</strong> <strong>Zeder Lutz, Gabrielle</strong> <strong>Cousido Siah, Alexandra</strong> <strong>Mitschler, Andre</strong> <strong>Katz, Aline</strong> <strong>Eberling, Pascal</strong> <strong>Mandel, Jean Louis</strong> <strong>Podjarny, Alberto</strong> <strong>Trottier, Yvon</strong> Source A related resource from which the described resource is derived Human Molecular Genetics v. 22, no. 20, 2013. -- p. 4215-4223 Publisher An entity responsible for making the resource available Oxford Academic Date A point or period of time associated with an event in the lifecycle of the resource 2013 Rights Information about rights held in and over the resource <p style="margin-bottom: 0cm;"><strong>Informaci&oacute;n sobre Derechos de Autor</strong><br /><br />(Por favor lea este aviso antes de abrir los documentos u objetos)<br /><br /><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes<br /><br />(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)<br /><br /><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p> Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource Ingl&eacute;s Type The nature or genre of the resource Art&iacute;culo Identifier An unambiguous reference to the resource within a given context https://doi.org/10.1093/hmg/ddt273 Anticuerpos Glutamina Péptidos Poliglutamina