<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6441">
    <dcterms:title><![CDATA[<strong>Synthesis and characterization of a bovine collagen:&nbsp;GAG scaffold with Uruguayan raw material for tissue engineering</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[COLAGENO]]></dcterms:subject>
    <dcterms:subject><![CDATA[BOVINOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[CELULAS MADRE]]></dcterms:subject>
    <dcterms:subject><![CDATA[RAYOS GAMMA]]></dcterms:subject>
    <dcterms:subject><![CDATA[TEJIDOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BILIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2021]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<p>Tissue engineering (TE) and regenerative medicine offer strategies to improve damaged tissues by using scaffolds and cells. The use of collagen-based biomaterials in the field of TE has been intensively growing over the past decades. Mesenchymal stromal cells (MSCs) and dental pulp stem cells (DPSCs) are promising cell candidates for development of clinical composites. In this study, we proposed the development<br />of a bovine collagen type I: chondroitin-6-sulphate (CG) scaffold, obtained from Uruguayan raw material (certified as free bovine spongiform encephalopathy), with CG crosslinking enhancement using different gamma radiation doses. Structural, biomechanical and chemical characteristics of the<br />scaffolds were assessed by Scanning Electron Microscopy,<br />axial tensile tests, FT-IR and Raman Spectroscopy,<br />respectively. Once we selected the most appropriate scaffold for future use as a TE product, we studied the behavior of MSCs and DPSCs cultured on the scaffold by cytotoxicity, proliferation and differentiation assays. Among the diverse porous scaffolds<br />obtained, the one with the most adequate properties was the one exposed to 15 kGy of gamma radiation.</p>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?9112f43c2970a47f27a7f91e16135af115ae4304ffe761984241471789ee20906ddb72757a066f41329792500c39496bd0cf6197f6e07b21d1f8aa6ce0c5206f" target="_blank"><strong>Pereira, L.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Echarte, L.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?78facf0d0598ff2d59e7d90838f411b31afeb5a103be562009253ef1cc970564aee3fa56b166096dc30501ce91cad2f944cbf24dc7018b21d346c5edead388b2" target="_blank"><strong>Romero, M.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Grazioli, G.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>P&eacute;rez Campos, H.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Francia, A.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vicentino, W.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?1b0a087e3c87093cbc890b5bf91c399442e82cecc6f88c2cf9bc2d893c994b60b23ca38b16378acce4a04af7b21e8aad8d2952e078de5c23f190942588f4006c" target="_blank"><strong>Mombr&uacute;, &Aacute;lvaro W.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?2f2e59581473324400ee29ded741b9090cc25a893e73d02669ebfbc674c9e8b9b51bb30e2bca064dc7ebbd5c39aa3c844e86e507301e912aa1b0a5ae17423fa2" target="_blank"><strong>Faccio, Ricardo</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>&Aacute;lvarez, I.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Touri&ntilde;o, C.</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a href="https://exportcvuy.anii.org.uy/cv/?90f8063f5d45d26487d94d93e9a22f454ec683bc1f137c80f0fce2ce741c123056026e93ea9c7f332f3a3d817c4c3ccd5a917070aab1f3fed4529ecff28b5dc4" target="_blank"><strong>Pardo, H.</strong></a>]]></dcterms:creator>
    <dcterms:source><![CDATA[Cell and Tissue Banking, 2021.]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2021]]></dcterms:date>
    <dcterms:rights><![CDATA[<p dir="ltr"><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p dir="ltr"><span>(Por favor lea este aviso antes de abrir los documentos u objetos)</span></p>
<p dir="ltr"><strong>La legislaci&oacute;n uruguaya protege el derechode autor</strong><span>&nbsp;sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</span></p>
<span id="docs-internal-guid-9d2103f7-7fff-c813-00c7-2528fd4891ff"><strong>ADVERTENCIA:</strong><span>&nbsp;La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</span></span>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[<span id="docs-internal-guid-592024b2-7fff-bbc7-0b28-f65cc7e3f0c4"><span>10.1007/s10561-021-09960-6</span></span>]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/6179">
    <dcterms:title><![CDATA[<strong>Current PBPK Models: Are They Predicting Tissue Drug Concentration Correctly?</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[FARMACOCINETICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[TEJIDOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[FARMACOS-CONCENTRACION]]></dcterms:subject>
    <dcterms:subject><![CDATA[MODELOS PBPK]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[2020]]></dcterms:subject>
    <dcterms:abstract><![CDATA[<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Ibarra, Manuel</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>V&aacute;zquez, Marta</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Fagiolino, Pietro</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Drugs in R&amp;D v. 20, 2020. -- p. 295&ndash;299]]></dcterms:source>
    <dcterms:publisher><![CDATA[Springer]]></dcterms:publisher>
    <dcterms:date><![CDATA[2020]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong> (Por favor lea este aviso antes de abrir los documentos u objetos)<strong> La legislaci&oacute;n uruguaya protege el derecho de autor </strong>sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[Pdf
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>
<div id="sconnect-is-installed" style="display: none;">2.11.0.0</div>]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[https://doi.org/10.1007/s40268-020-00325-0]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/3510">
    <dcterms:title><![CDATA[<strong>Light chain cardiomyopathy : structural analysis of the light chain tissue deposits.</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CARDIOMIOPATIA]]></dcterms:subject>
    <dcterms:subject><![CDATA[TEJIDOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:subject><![CDATA[1996]]></dcterms:subject>
    <dcterms:abstract><![CDATA[Cardiomyopathy due to monoclonal light chain deposits is a complication of plasma cell disorders. The deposits may be either fibrillar as in light chain amyloid or nonfibrillar as in light chain deposition disease. The reasons for these structural differences are still unknown. We characterized the myocardial deposits by immunohistochemical examination of sections and extraction and biochemical analysis of the tissue deposits in a patient (MCM) who died of myeloma and systemic light chain deposition disease. Amino acid sequence analysis of the extracted nonfibrillar MCM kappa-light chain reveals that it belongs to the L12a germline subset of the kappa(I) protein and contains five distinctive amino acid substitutions (three in the framework region III and two in the complementarity-determining region III) that have not been reported previously in the same positions in other kappa(I) light chains. The theoretically determined isoelectric point (pI 8.21) of the MCM light chain is high compared with the low isoelectric point of other Bence Jones proteins from subjects without light chain deposition disease. The diffuse binding to basement membranes and the high isoelectric point of the MCM kappa-light chain suggest electrostatic interaction as a possible mechanism of tissue deposition. The spatial locations of the five distinctive residues and a sixth rare substitution of the MCM protein modeled on the backbone structure of REI, a kappa(I)-soluble Bence Jones light chain of known three-dimensional structure, may be responsible for protein destabilization, partial unfolding, and aggregation leading to tissue deposition.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<strong>Gallo, G</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Go&ntilde;i, F</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Boctor, F</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Vidal, R</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Kumar, A</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Stevens, F.J</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Frangione, B</strong>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Ghiso, J</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[The American Journal of Pathology v. 148, no. 5, 1996. -- p. 1397-1406]]></dcterms:source>
    <dcterms:publisher><![CDATA[Elsevier]]></dcterms:publisher>
    <dcterms:date><![CDATA[1996]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislaci&oacute;n uruguaya</strong> protege el derecho de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes</p>
<p>(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA</strong> - La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN: 0002-9440]]></dcterms:identifier>
</rdf:Description><rdf:Description rdf:about="https://riquim.fq.edu.uy/items/show/2437">
    <dcterms:title><![CDATA[<strong>Isolation of a &szlig;-galactoside-binding lectin from cat liver</strong>]]></dcterms:title>
    <dcterms:subject><![CDATA[CARBOHIDRATOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[LACTOSA]]></dcterms:subject>
    <dcterms:subject><![CDATA[TEJIDOS]]></dcterms:subject>
    <dcterms:subject><![CDATA[PROTEINAS]]></dcterms:subject>
    <dcterms:subject><![CDATA[BIBLIOGRAFIA NACIONAL QUIMICA]]></dcterms:subject>
    <dcterms:abstract><![CDATA[A lectin from cat liver has been identified and purified by affinity chromatography on asialofetuin-Sepharose. One hundred micrograms of lectin was obtained from one cat liver with a purification factor of 1561. The lectin agglutinates trypsin-treated rabbit and cow erythrocytes. Hemagglutination was inhibited only by saccharides containing -galactosyl residues, of which the 1-amine-1-deoxy- -D-galactose was the most potent one by inhibiting hemagglutination at a concentration of 12.5 mM, followed by melibiose, trehalose and galactose. The lectin has a subunit molecular mass of 14.4 kDa determined by SDS-PAGE under reducing conditions and a pI of 4.85. Compared with the composition of lectins from calf heart and porcine heart, cat liver lectin contains approximately the same amount of cysteine, half the amount of glycine, twice as much arginine and threonine, and three times the amounts of tyrosine and methionine. Cat liver lectin contains four cysteine residues per subunit, all of them in the reduced form. Their lack of reactivity towards thiol-reactive supports suggests they are not exposed on the lectin surface. The protein apparently has a blocked N-terminus. The purified lectin was stable for up to 20 months stored at +4 C in buffer supplemented with 4 mM -mercaptoethanol. Results indicated that this lectin belongs to the family of soluble -galactoside-binding lectins, also known as galectins, which are expressed in a wide range of vertebrate tissues.]]></dcterms:abstract>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=729d3d9bb07d7be0ba5e4dc762c01e29" target="_blank"><strong>Franco-Fraguas, L.</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<a title="Curriculum Vitae" href="http://buscadores.anii.org.uy/buscador_sni/exportador/ExportarPdf?hash=8dfa5283acaafc5c73dab5b61b04f9a0" target="_blank"><strong>Batista-Viera, Francisco</strong></a>]]></dcterms:creator>
    <dcterms:creator><![CDATA[<strong>Carlsson, J.</strong>]]></dcterms:creator>
    <dcterms:source><![CDATA[Brazilian Journal Of Medical and Biological Research. v. 36, no. 4, 2003. -- p. 447-457]]></dcterms:source>
    <dcterms:publisher><![CDATA[Associa&ccedil;&atilde;o Brasileira de Divulga&ccedil;&atilde;o Cient&iacute;fica]]></dcterms:publisher>
    <dcterms:date><![CDATA[2003]]></dcterms:date>
    <dcterms:rights><![CDATA[<p><strong>Informaci&oacute;n sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong> La legislaci&oacute;n uruguaya protege el derecho</strong> de autor sobre toda creaci&oacute;n literaria, cient&iacute;fica o art&iacute;stica, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeci&oacute;n a lo establecido por el derecho com&uacute;n y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptaci&oacute;n de las siguientes condiciones de uso: Este documento es &uacute;nicamente para usos privados enmarcados en actividades de investigaci&oacute;n y docencia. No se autoriza su reproducci&oacute;n con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilizaci&oacute;n o cita de partes debe indicarse el nombre de la persona autora.</p>]]></dcterms:rights>
    <dcterms:format><![CDATA[PDF]]></dcterms:format>
    <dcterms:language><![CDATA[Ingl&eacute;s]]></dcterms:language>
    <dcterms:type><![CDATA[Art&iacute;culo]]></dcterms:type>
    <dcterms:identifier><![CDATA[ISSN 0100-879X]]></dcterms:identifier>
</rdf:Description></rdf:RDF>
