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https://riquim.fq.edu.uy/files/original/939c6f0b2749c13ea02fdcc558a642d5.pdf
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https://riquim.fq.edu.uy/files/original/ef83509d904b7326efd9a49daec08402.PNG
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8
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199
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147
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Title
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Bibliografía Nacional Química
Description
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Contiene la producción científica nacional de los profesionales químicos e investigadores, durante el período 1929 hasta la fecha.
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Departamento de Documentación y Biblioteca
RIQUIM
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PDF
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Title
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<strong>Purification and characterization of α-fucosidase from Dichostereum sordulentum 1488</strong>
Subject
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GLICOSIDASAS
ENZIMAS
CARBOHIDRATOS
A-L-FUCOSA
A-FUCOSIDASA
BIBLIOGRAFIA NACIONAL QUIMICA
2024
Abstract
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Biological glycans mediate several physiological processes, thus altered glycosylation patterns can lead to different diseases such as autoimmune, infectious, chronic anti-inflammatory diseases, or even cancer. In fact, alterations in fucosylation in either N- or O-glycans are among the most frequent changes in glycosylation patterns associated with cancer. Therefore, elucidation of the role of glycoconjugate glycans is essential for understanding the development of pathologies where they are involved. In this sense glycosidases are excellent tools, since they catalyse the selective removal of sugar residues, allowing the evaluation of changes in their biological role due to glycan removal. This work describes the purification and characterization of a α-fucosidase from the fungus Dichostereum sordulentum 1488. It is a homodimer with a molecular weight of 214 kDa and optimum pH and temperature of 4.0 and 70 ◦C respectively. It has a KM of 0.27 mM and VMax of 3.3 μmoles PNP/ min per mg for the substrate p-nitrophenyl-α-L-fucopyranoside, showing a substrate inhibition profile. It showed high specificity for the hydrolysis of fucose linked by α-(1,2) bonds. The identification, purification, and characterization of this new α-fucosidase is highly relevant for enlarging the availability of glycosidases for use as tools for glycan elucidation.
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<a href="https://export.cvuy.uy/cv/?89f4f95ef44a6b6cf3cc08494680b267"><strong>Herrera, Lorena</strong></a>
<a href="https://export.cvuy.uy/cv/?441488c6d1acc8438d8713846d7f670b"><strong>Cedrés, María Eugenia</strong></a>
<a href="https://export.cvuy.uy/cv/?a7dc62e1b1bbd449b3ac8472794ba2e52c18f2d4c52e9debc1b69bc3869e0f2eee9e4150d80c79f75a9876faa56a6b16a3a194119f3a19e8ff051ce749292a53"><strong>Rodríguez Bonnecarrére, Paula</strong></a>
<a href="https://export.cvuy.uy/cv/?8c80c1ae8b95cb6b8bc4b6ce3a8d3a39b297d1bd27a3804c09be97adcbe35a3741bd28180c0446feac51238afbedb3cf67010e8ed6fa462a13806c083463ea87"><strong>Giacomini, Cecilia</strong></a>
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Carbohydrate Research, v. 545, nº 1, 2024. -- e109278
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Elsevier
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2024
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<div class="element-text">
<p><strong>Información sobre Derechos de Autor</strong></p>
<p>(Por favor lea este aviso antes de abrir los documentos u objetos)</p>
<p><strong>La legislación uruguaya protege el derecho</strong> de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)</p>
<p><strong>ADVERTENCIA -</strong> La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.</p>
</div>
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PDF
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8 p.
Language
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Inglés
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Artículo
Identifier
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10.1016/j.carres.2024.109278
a-fucosidasa
a-L-fucosa
Carbohidratos
Enzimas
Glicosidasas