Emerging and existing mechanisms co-operate in generating diverse β-lactam resistance phenotypes in geographically dispersed and genetically disparate Pseudomonas aeruginosa strains

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Título

Emerging and existing mechanisms co-operate in generating diverse β-lactam resistance phenotypes in geographically dispersed and genetically disparate Pseudomonas aeruginosa strains

Tema

BACTERIAS
RESISTENCIA BACTERIANA
BETALACTAMICOS
PSEUDOMONAS AERUGINOSA
BIBLIOGRAFIA NACIONAL QUIMICA
2013

Abstract

β-Lactam resistance in Pseudomonas aeruginosa clinical isolates is driven by a number of mechanisms. Whilst several are understood, how they act co-operatively in pathogenic strains is less clear. In some isolates, resistance profiles cannot always be explained by identifying the common resistance-determining pathways, suggesting that other mechanisms may be important. Pathogenic P. aeruginosa isolates from four countries were characterised by PCR. Quantitative expression analysis was also assessed for the activity of several pathways that influence antibiotic resistance, and culture experiments were conducted to test how random transposition of the insertion sequence IS26 during growth may influence resistance to some antibiotics. In most strains, antibiotic resistance was being driven by changes in multiple pathways and by the presence or absence of genes acquired by lateral gene transfer. Multiple mechanisms of resistance were prevalent in strains from all of the countries examined, although regional differences in the type of interacting mechanisms were apparent. Changes in chromosomal pathways included overexpression of AmpC and two efflux pumps. Also, gain or loss of IS26 at some chromosomal locations, most notably oprD, could influence resistance to carbapenems. IS26-related resistance was found in strains from Argentina and geographically linked Uruguay, but not in strains from either Colombia or Australia. Pseudomonas aeruginosa pathogenic strains are evolving to become multidrug-resistant in more complex ways. This is being influenced by single strains acquiring changes in numerous known pathways as well as by newly emerging resistance mechanisms in this species.

Autor

Martínez, Elena
Escobar Pérez, Javier
Vilacoba, Elisabet
Centrón, Daniela
Leal, Aura L.
Saavedra, Carlos
Saavedra, Sandra Y.
Tovar, Catalina
Vanegas, Natasha
Stokes, H. W.

Fuente

Journal of Global Antimicrobial Resistance v. 1, no. 3, 2013. -- p. 135-142

Editor

Elsevier

Fecha

2013

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Artículo

Identificador

ISSN: 2213-7165
Fecha de agregación
December 9, 2013
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Martínez, Elena, “Emerging and existing mechanisms co-operate in generating diverse β-lactam resistance phenotypes in geographically dispersed and genetically disparate Pseudomonas aeruginosa strains,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed January 28, 2023, http://riquim.fq.edu.uy/items/show/1163.
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