Therapeutic drug monitoring of vancomycin in severe sepsis and septic shock

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Título

Therapeutic drug monitoring of vancomycin in severe sepsis and septic shock

Tema

MONITOREO DE DROGAS
TERAPEUTICA
FARMACOLOGIA
VANCOMICINA
2008
BIBLIOGRAFÍA NACIONAL QUÍMICA

Abstract

Background: The sudden changes (increase in capillar permeability, edema formation, vasodilation and hypotension) observed in septic patients and the measurements taken in order to revert this situation make vancomycin concentrations difficult to interpret. Therapeutic drug monitoring (TDM) of vancomycin is routinely performed at steady state, target concentrations are peaks between 20 and 40 mg/l and troughs of 5 – 10 mg/l. Lately, continuous infusion of vancomycin (CIV) has been used as an alternative mode of administration mainly in critically ill patients with sepsis or septic shock. Despite this novel mode of administration, the need of drug monitoring in this population is under discussion. Objective: The aim of our study was to test the usefulness of a multi-compartment model in order to understand the rapid changes that occur in critically ill patients. Materials and methods: A prospective, cohort study was carried out in the intensive care unit of the University Hospital. 25 intensive care unit adults patients with severe sepsis or septic shock receiving vancomycin in CIV modality for documented gram-positive infections were included in the study. Once the infusion was started, blood samples were drawn periodically and analized by fluorescence polarisation immunoassay (FPIA, TDx, Abbott Laboratories, Chicago, IL, USA). A multi-compartment model was used to predict vancomycin level evolution throughout the treatment of patients with sepsis. Results: High doses of vancomycin were administered in order to rescue patients from septic shock. Plasma drug concentration dropped while clinical condition of patients worsened. Conversely, drug levels increased spontaneously once the infection was reverted. The theoretical model provided greater insight into pharmacokinetic features related with the use of vancomycin in septic patients. Conclusions: There was consistency between the model based prediction and the experimental data so dose adjustment was performed in order to reach target concentrations above 20 mg/l and an initial dose of 3 grams of vancomycin per day was recommended to reach these levels.

Autor

Vázquez, M.
Boronat, A.
Buroni, M.
Maldonado, C.

Fuente

International Journal of Clinical Pharmacology and Therapeutics v. 46, no.3, 2008. -- p. 140-145

Editor

Dustri-Verlag

Fecha

2008

Derechos

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PDF

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Inglés

Tipo

Artículo

Identificador

ISSN 0946-1965
Fecha de agregación
November 21, 2014
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Vázquez, M., “Therapeutic drug monitoring of vancomycin in severe sepsis and septic shock,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed August 22, 2019, http://riquim.fq.edu.uy/items/show/2037.
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